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Kim Tae Hwan TH 1 Department of Radiotherapy, The First Affiliated Hospital, Guangxi Medical University , Nanning, China - - 2014
Abstract Khz (a fusion mycelium of Ganoderma lucidum and Polyporus umbellatus mycelia) is isolated from ganoderic acid and P. umbellatus and it exerts antiproliferative effects against malignant cells. However, no previous study has reported the inhibitory effects of Khz on the growth of human colon cancer cells. In the present ...
Singleton D C DC Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, - - 2014
Hypoxia is a common feature of locally advanced breast cancers that is associated with increased metastasis and poorer survival. Stabilisation of hypoxia-inducible factor-1α (HIF1α) in tumours causes transcriptional changes in numerous genes that function at distinct stages of the metastatic cascade. We demonstrate that expression of RIOK3 (RIght Open reading ...
Nikolovska Katerina - - 2014
Fibroblast growth factor-2 (Ffg2) is involved in several biological functions. Fgf2 requires glycosaminoglycans, like chondroitin/dermatan sulfate (CS/DS) as co-receptors. CS/DS are linear polysaccharides composed of repeating disaccharide units [-4GlcUAβ1-3-GalNAc-β1-] and [-4IdoUAα1-3-GalNAc-β1-], which can be sulfated. Uronyl 2-O-sulfotransferase (Ust) introduces sulfation at the C2 of IdoUA and GlcUA resulting in over-sulfated ...
Hagos Yohannes Y University Göttingen - - 2014
Chronic lymphatic leukaemia (CLL) is often associated with nephritic syndrome. Effective treatment of CLL by chlorambucil and bendamustine leads to restoration of renal function. In this contribution, we sought to elucidate the impact of the organic anion transporters on the uptake of bendamustine and chlorambucil as a probable reason for ...
Woo Mi-Seon MS Department of Biomedical Science, CHA University, Kyonggi, 463-836, South - - 2014
Ellagic acid (EA) is a natural polyphenol found in various fruits and vegetables. In this study, we examined the inhibitory effect of EA on fat accumulation in 3T3-L1 cells during adipogenesis. Our data showed that EA reduced fat accumulation by down-regulating adipogenic markers such as peroxisome proliferator activated receptor γ ...
Leighton Daniel H W DH Howard Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA - - 2014
Males of the androdioecious species Caenorhabditis elegans are more likely to attempt to mate with and successfully inseminate C. elegans hermaphrodites that do not concurrently harbor sperm. Although a small number of genes have been implicated in this effect, the mechanism by which it arises remains unknown. In the context ...
Mizuuchi Yusuke Y 1] Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan [2] Reserch Fellow of Japan Society for the Promotion of Science, Tokyo, - - 2014
Anterior gradient 2 (AGR2), a member of the protein disulfide isomerase family, has been implicated in various cancers including pancreatic ductal adenocarcinoma (PDAC) and is known to promote cancer progression. However, the prognostic value of AGR2 expression and the interaction with epithelial-mesenchymal transition (EMT) remain unclear. We investigated the clinical ...
Chang Jia-Yaw - - 2014
A simple one-pot approach was developed to obtain off-stoichiometric CuInS2 nanocrystals. Using this approach, both In-rich and Cu-rich CuInS2 nanocrystals could be reliably synthesized by tuning stoichiometric combinations of [Cu]:[In] precursor constituents. By designing Cu-rich CuInS2 heteronanostructures to serve as counter electrodes, quantum-dot-sensitized solar cells (QDSSCs) equipped with In-rich CuInS2 ...
Chiesi C C Dipartimento di Scienze Economico-Estimative e degli Alimenti, Sezione di Chimica Bromatologica, Biochimica, Fisiologia e Nutrizione, Facoltà di Farmacia, Università degli Studi di Perugia, Perugia, - - 2014
The extra virgin olive oil (EVOO) has been associated to antioxidant effects. The mycotoxin alternariol (AOH) can contaminate olives. The aims of this work were to determine the cytotoxic effects and reactive oxygen species (ROS) produced by AOH, tyrosol and oleuropein (two polyphenols of olive oil) and a real EVOO ...
D Angelo Daniela - - 2014
Development of resistance to conventional drugs and novel biological agents often impair long-term chemotherapy. HMGA gene overexpression is often associated with antineoplastic drug resistance and reduced survival. Inhibition of HMGA expression in thyroid cancer cells reduces levels of ATM protein, the main cellular sensor of DNA damage, and enhances cellular ...
Lee Hyunseung H University of Texas Health Science Center at San Antonio, United - - 2014
Chronic exposure of UV radiation can contribute to the development of skin cancer by promoting PTK signaling. Studies show that exposure to UV radiation increases the ligand-independent activation of PTKs and induces PTP inactivation. In the present work, we report that TC-PTP activity is stimulated during the initial response to ...
Asare George Awuku GA University of Ghana, Accra, Ghana - - 2014
Background. Annona muricata L. has been reported to possess antitumor and antiproliferative properties. Not much work has been done on its effect on BPH-1 cell lines, and no in vivo studies targeting the prostate organ exist. The study determined the effect of A muricata on human BPH-1 cells and prostate ...
Zanotti Kimberly J KJ Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; - - 2014
Mammalian ATPase family AAA domain-containing protein 5 (ATAD5) and its yeast homolog enhanced level of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly synthesized DNA. Prior work in HeLa and yeast cells showed that a decrease in ATAD5 protein levels resulted in accumulation of chromatin-bound ...
Teerds Katja J KJ Department of Animal Sciences, Human and Animal Physiology, Wageningen University, De Elst 1, 6709 WD Wageningen, The - - 2014
Disruption of normal fetal development can influence functioning of organs and cells in adulthood. Circumstantial evidence suggests that subtle reductions in fetal androgen production may be the cause of adult male reproductive disorders due to reduced testosterone production. The mechanisms through which these fetal events affect adult testosterone levels are ...
Buendia Izaskun - - 2014
We have investigated the protective effects of ITH91/IQM157, a hybrid of melatonin and N,N-dibenzyl(N-methyl)amine, in an in vitro model of AD-like pathology that combines amyloid beta (Aβ) and tau hyperphosphorylation induced by okadaic acid (OA), in the human neuroblastoma cell line SH-SY5Y. Combination of sub-toxic concentrations of Aβ and OA ...
Chimerel Catalin C Institute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK. Electronic address: - - 2014
It has long been speculated that metabolites, produced by gut microbiota, influence host metabolism in health and diseases. Here, we reveal that indole, a metabolite produced from the dissimilation of tryptophan, is able to modulate the secretion of glucagon-like peptide-1 (GLP-1) from immortalized and primary mouse colonic L cells. Indole increased ...
Louandre Christophe C Laboratoire de Biochimie, CHU Amiens, Amiens, - - 2014
Sorafenib is the treatment of reference for advanced hepatocellular carcinoma (HCC), the most frequent form of primary liver tumour. The loss of function of the retinoblastoma (Rb) protein is an important event during liver carcinogenesis, but it is unclear whether the Rb status modulates the response of HCC cells to ...
Kido Natsumi N Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, 980-8578, - - 2014
Poales (represented by rice [Oryza sativa L.]) in angiosperms and Equisetum (horsetails) in Pteridophytes are two major groups of heavy silicon (Si) accumulators. In rice, Si is polymerized preferentially in the epidermal cell wall, forming Si-cuticle double layers beneath the cuticle. This Si layer is thought to exert various beneficial ...
Groneberg Dieter D Physiologisches Institut I, Universität Würzburg, Würzburg, - - 2014
Esophageal achalasia is a disease known to result from reduced relaxation of the lower esophageal sphincter. Nitric oxide (NO) is one of the main inhibitory transmitters. NO-sensitive guanylyl cyclase (NO-GC) acts as the key target of NO and, by the generation of cGMP, mediates nitrergic relaxation in the lower esophageal ...
Pinilla Yudi T YT Medical and Forensic Entomology Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia. Electronic address: - - 2014
Sarconesiopsis magellanica is a necrophagous blowfly which is relevant in both forensic and medical sciences. Previous studies regarding this species have led to understanding life-cycle, population and reproduction parameters, as well as identifying and characterising proteolytic enzymes derived from larval excretions and secretions (ES). As other studies have shown that ...
Hahm Sahng-Wook SW 1 Institute of Life Science and Natural Resources, College of Life Sciences and Biotechnology, Korea University , Seoul, - - 2014
Abstract In this study, we found that the total polyphenol and ascorbic acid levels in the fruit of Opuntia humifusa are higher than those in other parts of the plant. We further hypothesized that antioxidants in O. humifusa might affect the growth or survival of cancer cells. Hexane extracts of ...
Lv Huicheng H Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 404000, P.R. China ; Department of Orthopaedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. - - 2014
As the most common malignant primary bone tumor in childhood, osteosarcoma (OS) maintains a high recurrence, despite the significant improvements in the overall survival rate of high-grade OS patients during the recent decades. Therefore, a novel therapy strategy is required for OS treatment. Recently, various microRNAs (miRNAs or miRs) have ...
Zafar Sobiya S Nano Research Lab Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, - - 2014
The present work describes the preparation of sterically stabilize polymeric nanoparticles of mitoxantrone dihydrochloride (MTO) along with an efflux transporter (Pgp/BCRP) inhibitor that enhance the circulation time of nanoparticles and simultaneously surmount the problem of multidrug resistance (MDR). Mitoxantrone dihydrochloride being hydrophilic in nature had very low entrapment efficiency (%E.E.), ...
Nadella Vinod V School of Life & Health Sciences, Aston University, Birmingham B4 7ET, UK; Aston Research Centre for Healthy Ageing, Aston University, Birmingham B4 7ET, - - 2015
Tissue transglutaminase (TG2) is a multifunctional protein cross-linking enzyme that has been implicated in apoptotic cell clearance but is also important in many other cell functions including cell adhesion, migration and monocyte to macrophage differentiation. Cell surface-associated TG2 regulates cell adhesion and migration, via its association with receptors such as ...
Kim Chung Hun CH Department of Plastic and Reconstructive Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si, Gyeonggi-do, Republic of - - 2014
Some malignant cancers show high levels of local invasiveness by the secretion of soluble factors that can degrade adjacent tissues and suppress surrounding cell growth. We investigated the possibility of treating fibroproliferative scars based on these properties of malignant melanoma. B16 melanoma-conditioned medium (B16 M-CM) was added to keloid fibroblasts ...
Kim Dae-Hwan DH Energy Research Division, Daegu Gyeongbuk Institute of Science & Technology, 333, Techno jungang-daero, Hyeonpung-myeon, Dalseong-gun, Daegu 711-873, Republic of Korea. imromy@khu.ac.kr - - 2014
A high-quality Sb2S3 thin-absorber with controllable thickness was reproducibly formed by atomic layer deposition (ALD) technique. Compared with conventional chemical bath deposition (CBD), the Sb2S3 absorber deposited by ALD did not contain oxide or oxygen impurities and showed a very uniform thickness of Sb2S3 absorbers formed on a rough surface ...
Wang YouPing - - 2014
AML with Mt NPM1 has relatively good responses to induction therapy. However, a proportion of NPMc+ AML cells cannot be cleared by conventional treatments. Therefore, we determined the therapeutic efficacy of deguelin that has demonstrated extensive biological activity with low toxicity. We previously reported that deguelin selectively reduces Mt NPM1, ...
Gasparini Nicola - - 2014
The replacement of common fullerene derivatives with neat-C70 could be an effective approach to restrain the costs of organic photovoltaics and increase their sustainability. In this study, bulk-heterojunction solar cells made of neat-C70 and low energy-gap conjugated polymers, PTB7 and PCDTBT, are thoroughly investigated and compared. Upon replacing PC70BM with ...
Kazami T T Department of Molecular Diagnosis (F8), Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, - - 2014
Most human cancers show chromosomal instability (CIN), but the precise mechanisms remain uncertain. Annexin A2 is frequently overexpressed in human cancers, and its relationship to tumorigenesis is poorly understood. We found that annexin A2 is overexpressed in the nuclei of CIN cells compared with cells with microsatellite instability (MIN). Ectopic ...
Nakamura Takashi - - 2014
The basal layer of the epidermis contains stem cells and transit amplifying (TA) cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number of molecules have been identified as regulators for this process including p63 and Notch1. However, little is known about the mechanisms ...
Ainger Stephen A SA Institute for Molecular Bioscience, Melanogenix Group, The University of Queensland, Brisbane, Qld, 4072, - - 2014
Dopachrome tautomerase (DCT) is involved in the formation of the photoprotective skin pigment eumelanin, and has also been shown to have a role in response to apoptotic stimuli and oxidative stress. The effect of DCT on UVR DNA damage responses and survival pathways in human melanocytic cells was examined by ...
Cerezo Maria Isabel MI Department of Global Change Research, IMEDEA (CSIC-UIB), Instituto Mediterráneo de Estudios Avanzados, Miquel Marqués 21, 07190 Esporles, Spain. Electronic address: - - 2014
The cyanobacteria Prochlorococcus is the most abundant primary producer in the ocean. In a global study across the Atlantic, Indian and Pacific Oceans, we tested the effect of organic pollutants on the growth and cell division of natural Prochlorococcus populations. Sub-lethal concentrations of Polycyclic Aromatic Hydrocarbons (PAHs) altered Prochlorococcus cell ...
Berchtold Sonja S Institute of Pathology, Technische Universität München, Munich, - - 2014
Excessive matrix production by pancreatic stellate cells promotes local growth and metastasis of pancreatic ductal adenocarcinoma and provides a barrier for drug delivery. Collagen type V is a fibrillar, regulatory collagen up-regulated in the stroma of different malignant tumors. Here we show that collagen type V is expressed by pancreatic ...
Pilizota Teuta T Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey; School of Biology and Centre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh, United Kingdom. Electronic address: - - 2014
In Escherichia coli, a sudden increase in external concentration causes a pressure drop across the cell envelope, followed by an active recovery. After recovery, and if the external osmolality remains high, cells have been shown to grow more slowly, smaller, and at reduced turgor pressure. Despite the fact that the ...
Yang Xiaobing X Division of Biotechnology and Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, CAS, Dalian 116023, China; School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China; University of Chinese Academy of Sciences, Beijing 100049, - - 2014
To reduce wastes and the costs of microbial lipid production, it is imperative to recycle resources, including spent cell mass, mineral nutrients and water. In the present study, lipid production by the oleaginous yeast Rhodosporidium toruloides was used as a model system to demonstrate resources recycling. It was found that ...
Kondath Sindhu S Biochemistry Laboratory, Central Leather Research Institute, Adyar, Chennai, - - 2014
There is significant interest in investigating the therapeutic potential of phytochemical reduced and bound gold nanoparticles (AuNPs) as it bridges the gap between nanotechnology and therapy. In the present study, AuNPs prepared using the flavonoid morin (mAuNPs) are characterised and have been studied for their anti-cancer effects. The -OH groups ...
Jaganathan Sajjeev S The Vontz Center for Molecular Studies, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267. Division of Hematology and Oncology, University of Cincinnati College of Medicine, Cincinnati, OH - - 2014
The proteasome inhibitor bortezomib is an effective anti-cancer agent for the plasma cell malignancy multiple myeloma but clinical response is hindered by the emergence of drug resistance through unknown mechanisms. Drug sensitive myeloma cells were exposed to bortezomib to generate drug resistant cells that displayed a significant increase in subunits ...
Nagy Dénes D Department of Physiology, Faculty of General Medicine, University of Debrecen, Nagyerdei krt 98, PO Box 22, 4012, Debrecen, - - 2014
TASK-3 (KCNK9 or K2P9.1) channels are thought to promote proliferation and/or survival of malignantly transformed cells, most likely by increasing their hypoxia tolerance. Based on our previous results that suggested mitochondrial expression of TASK-3 channels, we hypothesized that TASK-3 channels have roles in maintaining mitochondrial activity. In the present work ...
Zuo Yan Y Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX - - 2014
Net1 is a RhoA subfamily specific guanine nucleotide exchange factor that is overexpressed in human breast cancer and is required for breast cancer cell migration and invasion. However, the role of Net1 in normal mammary gland development or function has never been assessed. To understand the role of Net1 in ...
Oakes Vanessa V a The University of Queensland Diamantina Institute; Translational Research Institute ; Brisbane , Queensland , - - 2014
Whereas many components regulating the progression from S phase through G2 phase into mitosis have been identified, the mechanism by which these components control this critical cell cycle progression is still not fully elucidated. Cyclin A/Cdk2 has been shown to regulate the timing of Cyclin B/Cdk1 activation and progression into ...
Unternaehrer Juli J JJ Division of Pediatric Hematology/Oncology, Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Harvard University, Cambridge, MA 02138, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: - - 2014
Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) paradoxically reduced, while overexpression enhanced, reprogramming efficiency in human cells and ...
Lee Byunghong - - 2014
We introduce a new class of molecular iodosalt compounds for application in next-generation solar cells. Unlike tin-based perovskite compounds CsSnI3 and CH3NH3SnI3 which have Sn in 2+ oxidation state and must be handled in inert atmosphere when fabricating solar cells, the Sn in the molecular iodosalt compounds is in the ...
Cobine C A CA Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada - - 2014
The effector cells and second messengers participating in nitrergic neuromuscular transmission (NMT) were investigated in the mouse internal anal sphincter (IAS). Protein expression of guanylate cyclase (GCα, GCβ) and cyclic GMP-dependent protein kinase I (cGKI) were examined in cryostat sections with dual-labeling immunohistochemical techniques in PDGFRα(+) cells, interstitial cells of ...
Radde Brandie N - - 2014
Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated charcoal (DCC)-stripped fetal bovine serum (FBS)-containing medium ...
Im A-Rang - - 2014
Mitochondrial dysfunction has been implicated in neuronal apoptosis associated with neurodegenerative diseases such as Huntington's disease (HD). Animals that are administered 3-nitropropionic acid (3-NP), a mitochondrial toxin that specifically inhibits complex II of the mitochondrial electron transport chain, manifest HD-like symptoms. Psoralea corylifolia Linn seed extracts against 3-NP induced mitochondrial ...
Zatyka M M Department of Medical and Molecular Genetics, University of Birmingham, Birmingham, B15 2TT, - - 2014
Wolfram syndrome is an autosomal recessive disorder characterised by neurodegeneration and diabetes mellitus. The gene responsible for the syndrome (WFS1) encodes an endoplasmic reticulum (ER)-resident transmembrane protein that is involved in the regulation of the unfolded protein response, intracellular ion homeostasis, cyclic AMP production and regulation of insulin biosynthesis and ...
Tiwari Ankana A Indian Institute of Science, - - 2014
ESRRA functions as a transcription factor and regulates the expression of several genes, such as WNT11 and OPN. Upregulation of ESRRA has been reported in several cancers. However, the mechanism underlying its upregulation is unclear. Further, the reports regarding the role and regulation of ESRRA in oral squamous cell carcinoma ...
Ti Yunfan Y Department of Orthopedics of Jinling Hospital, School of Medicine, Nanjing University, 305 Zhongshan East Rd, Nanjing, 210002, - - 2014
Osteoclast is the only cell that can degrade bone tissue in vivo. Recent studies have shown the important role of cytoskeleton dynamics in osteolysis and the formation of podosome belt in osteoclasts. This process is regulated by the dynamic microtubule (MT) network. We treated osteoclast precursor cells Raw264.7 with low ...
Mansour Marc R MR Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Haematology, UCL Cancer Institute, University College London, London, - - 2014
Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independent activation of STAT5. We hypothesized that the reducing agent N-acetylcysteine (NAC), ...
Sørensen Belinda Halling BH University of - - 2014
Cisplatin resistance is a major challenge in the treatment of cancer and develops through reduced drug accumulation and an increased ability to avoid drug-induced cell damage, cell shrinkage and hence initiation of apoptosis. Uptake and release of the semi-essential amino acid taurine contribute to cell volume homeostasis and taurine has ...
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