Search Results
Results 1 - 50 of 1912
1 2 3 4 5 6 7 8 9 10 >
Wang Xiaolei X College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, - - 2014
Determination of intracellular bioactive species will afford beneficial information related to cell metabolism, signal transduction, cell function, and disease treatment. In this study, the electrochemically reduced graphene oxide modified carbon fiber microdisk electrode (ER-GOME) was used to be the detector of capillary zone electrophoresis-electrochemical detection and developed to detect glutathione ...
Kayastha Forum F Iladevi Cataract and IOL Research Centre, Gurukul road, Memnagar, Ahmedabad-380052, - - 2014
Lens epithelial cell proliferation, migration, and transdifferentiation are involved in the development of subcapsular cataracts and postoperative capsular opacification (PCO). PI3K/Akt pathway is involved in the proliferation and migration of lens epithelial cells. Andrographolide is the main bioactive component of Andrographis paniculata and is known to possess anti-proliferative and anti-migratory ...
Mane Shivshankar R - - 2014
Stimuli responsive polymeric nanocarrier (RCOP-2) functionalized with frontline anti tuberculosis drug (rifampicin) is demonstrated for the sustained release. Bioavailability of rifampicin is taken care by conjugating it through a hydrazone linker to the polymeric backbone. PEG motif is introduced in the copolymer architecture for the water solubility. Releasing retinal along ...
Kalve Shweta S Department of Biology, University of Antwerp, - - 2014
Variations in size and shape of multicellular organs depend on spatio-temporal regulation of cell division and expansion. Here, cell division and expansion rates were quantified relative to the three spatial axes in the first leaf pair of Arabidopsis thaliana. The results show striking differences in expansion rates: the expansion rate ...
Zhang Chang C http://orcid.org/0000-0003-1517-2377 University of - - 2014
Abscisic Acid (ABA) modulates root growth in plants grown under normal and stress conditions and can rescue the root growth defects of the Medicago truncatula lateral root-organ defective (latd) mutant. Here we demonstrate that Reactive Oxygen Species (ROS) function downstream of ABA in the regulation of root growth by controlling ...
Baïlo Nathalie - - 2014
Dictyostelium discoideum ACAP-A is an Arf-GTPase-activating protein involved in cytokinesis, cell migration and actin cytoskeleton dynamics. In mammalian cells, ACAP family members regulate endocytic protein trafficking. Here we explored the function of ACAP-A in the endocytic pathway of D. discoideum. In the absence of ACAP-A, reduced fusion efficacy of post-lysosomes ...
Hotz Birgit B Department of Surgery I, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, - - 2014
The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for metastasis. The aim of this study was to elucidate the effects of low-dose TRD on pancreatic cancer. Human pancreatic ...
Tang J J Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, - - 2014
Osteosarcoma (OS) is one of the most common primary malignant bone tumours of childhood and adolescence, and is characterized by high propensity for metastasis (specially to the lung), which is the main cause of death. However, molecular mechanisms underlying metastasis of OS are still poorly understood. Metadherin (MTDH) was identified ...
Chao Ming-Wei MW Department of BioScience Technology, Chung Yuan Christian University, Chungli, Taoyuan, Taiwan, 320; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Exposure to monocyclic aromatic alkylanilines (MAAs), namely 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA) and 3-ethylaniline (3-EA), was significantly and independently associated with bladder cancer incidence. 3,5-DMAP (3,5-dimethylaminophenol), a metabolite of 3,5-DMA, was shown to induce an imbalance in cytotoxicity cellular antioxidant/oxidant status, and DNA damage in mammalian cell lines. This study was ...
Zhang Wenchao W Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Obstetrics and Gynecology, Yangpu District Central Hospital, Shanghai, - - 2014
Myosin is involved in cell contraction and motility, but it is unclear whether it is involved in cell proliferation in uterine myoma. In this study therefore we aimed to explore the role of myosin in uterine myoma. Immunohistochemistry and real-time polymerase chain reaction were used to determine the expression of ...
McElroy Steven J SJ Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, - - 2014
Necrotizing enterocolitis (NEC) affects up to 10% of premature infants, has a mortality of 30%, and can leave surviving patients with significant morbidity. Neuregulin-4 (NRG4) is an ErbB4-specific ligand that promotes epithelial cell survival. Thus, this pathway could be protective in diseases such as NEC, in which epithelial cell death ...
Fernández Diego A DA Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Campus Universitario, 27002 Lugo, - - 2014
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in ecological and human risk. In order to reach the bloodstream ...
Lou Chenghua C Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, - - 2014
Nuclear factor-κB (NF-κB) activation has been implicated not only in carcinogenesis but also in cancer cell invasion and metastatic process; therefore, targeting the NF-κB pathway is an attractive strategy for controlling meta-stasis. Amongst 56 chemically defined compounds derived from natural products, we have identified a new phytochemical compound Hirsutine, which ...
Liu Ruihua R State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, 300071, - - 2014
Many ecosystems are currently co-contaminated with pesticides and heavy metals, such as chlorpyrifos and cadmium. A promising strategy to remediate mixed chlorpyrifos-cadmium-contaminated sites is the use of chlorpyrifos-degrading bacteria endowed with cadmium removal capabilities. In this work, a gene coding for synthetic phytochelatins (EC20) with high cadmium-binding capacity was introduced ...
Bjelic Maja M MM Reproductive Endocrinology and Signaling Group, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, - - 2014
This study systematically evaluates the effects of androgen receptor (AR) blockade on molecular events in Leydig cells. Results showed that intramuscular administration of testosterone-enanthate, at clinically relevant dose, decreased testosterone in interstitial fluid and Leydig cells from adult rats. AR-blocker (Androcur) prevented this effect and testosterone-reduced Leydig cells steroidogenic capacity/activity. ...
Sun Li L State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Haidian, Beijing 100085, P.R. - - 2014
Chlorpyrifos (CPF) is commonly used for agricultural and domestic applications, and its contamination is widely detected in environmental media, and in a broad spectrum of field crops, fruits and vegetables. CPF exposure causes many adverse effects on human health including hepatoxicity, neurotoxicity and endocrine disruption. However, few studies have been ...
Chen Wen W School of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China ; School of Pharmacy, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Reigion, - - 2014
Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell growth. In this study, amino-functionalized ethylenediamine-treated multi-walled carbon nanotubes were used to prepare carbon nanotubes-nerve growth factor complexes by non-covalent ...
Hoyer Patricia B PB The University of Arizona, College of Medicine, Department of Physiology , 1501 N. Campbell Ave, Tucson AZ 85724 , USA +1 520 626 6688 ; +1 520 626 2382 ; - - 2014
Introduction: Damage caused by xenobiotic compounds to the ovaries is a subject of concern because of their critical role in reproduction. Female mammals are born with a finite number of germ cells (oocytes) encased in primordial follicles. Xenobiotic-induced damage to primordial follicles can result in early ovarian failure (premature menopause). ...
Franklin Robin J M RJ Wellcome Trust-MRC Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, United - - 2014
Amongst neurological diseases, multiple sclerosis (MS) presents an attractive target for regenerative medicine. This is because the primary pathology, the loss of myelin-forming oligodendrocytes, can be followed by a spontaneous and efficient regenerative process called remyelination. While cell transplantation approaches have been explored as a means of replacing lost oligodendrocytes, ...
Chandra V V Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, - - 2014
Endometrial hyperplasia is a precursor to the most common gynecologic cancer diagnosed in women. Apart from estrogenic induction, aberrant activation of the Wnt/β-catenin signal is well known to correlate with endometrial hyperplasia and its carcinoma. The benzopyran compound 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo (b) pyran(K-1), a potent antiestrogenic agent, has been shown to have ...
Gnanapragassam Vinayaga S VS Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, Halle (Saale), - - 2014
Sialic acids (Sia) represent negative-charged terminal sugars on most glycoproteins and glycolipids on the cell surface of vertebrates. Aberrant expression of tumor associated sialylated carbohydrate epitopes significantly increases during onset of cancer. Since Sia contribute towards cell migration ( =  metastasis) and to chemo- and radiation resistance. Modulation of cellular Sia ...
Touret Franck - - 2014
The endosymbiotic bacteria of the genus Wolbachia are present in most insects and are maternally transmitted through the germline. Moreover, these intracellular bacteria exert antiviral activity against insect RNA viruses, as in Drosophila melanogaster, which could explain the prevalence of Wolbachia bacteria in natural populations. Wolbachia is maternally transmitted in ...
Brahmachari Sayanti S Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata, - - 2014
The present article reports the development of soft nanohybrids comprising of single walled carbon nanotube (SWCNT) included silver nanoparticles (AgNPs) having superior antibacterial property. In this regard aqueous dispersing agent of carbon nanotube (CNT) containing a silver ion reducing unit was synthesised by the inclusion of tryptophan and tyrosine within ...
Lin Jen-Jie JJ Graduate Institute of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 91202, Taiwan. - - 2014
Cancer metastasis is one of the major causes of death in cancer. An active compound, 11-epi-sinulariolide acetate (11-epi-SA), isolated from the cultured soft coral Sinularia flexibilis has been examined for potential anti-cell migration and invasion effects on hepatocellular carcinoma cells (HCC). However, the molecular mechanism of anti-migration and invasion by ...
Hirayama Masatoshi - - 2013
: Current approaches for the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs to replace lost or damaged organs that result from disease, injury, or ...
Hansen Dave - - 2013
The C. elegans germ line has emerged as an important model for -understanding how a stem cell population is maintained throughout the life of the animal while still producing the gametes necessary for propagation of the species. The stem cell population in the adult hermaphrodite is relatively large, with stem ...
Kadam Shilpa D SD Neuroscience Laboratory, Hugo W Moser Research Institute ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
Auto antibodies found in the mothers of children with autistic disorder (MCAD) when passively transferred to pregnant mice cause behavioral alterations in juvenile and adult offspring. The goal of this study was to identify whether intraperitoneal injection of MCAD-IgG during gestation affected postnatal cell proliferation and survival in P7 offspring. ...
Prockop Darwin J - - 2012
A recent publication by Phinney and his associates ( 1 ) has presented a discovery for which the field of cell biology has been waiting for more than half a century: a protocol that makes it possible to expand mouse cells in culture without the cells spontaneously transforming. Amazing though ...
Baskin Tobias I - - 2012
The extracellular matrix is constructed beyond the plasma membrane, challenging mechanisms for its control by the cell. In plants, the cell wall is highly ordered, with cellulose microfibrils aligned coherently over a scale spanning hundreds of cells. To a considerable extent, deploying aligned microfibrils determines mechanical properties of the cell ...
Robertson Francesca F MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London, WC1E 6BT, - - 2012
Morphogenesis of epithelial tissues relies on the interplay between cell division, differentiation and regulated changes in cell shape, intercalation and sorting. These processes are often studied individually in relatively simple epithelia that lack the complexity found during organogenesis when these processes might all coexist simultaneously. To address this issue, we ...
Garcia Juan Luis - - 2012
Even though much progress has been made towards understanding the molecular nature of glioma, the survival rates of patients affected by this tumour have not changed significantly over recent years. Better knowledge of this malignancy is still needed in order to predict its outcome and improve patient treatment. VAV1 is ...
Wen Jason W H - - 2012
Primitive endoderm formation from the inner cell mass is one of the earliest known cell fate decisions made in the mouse embryo. The mechanisms involved in orchestrating this process are not fully understood and are difficult to study in vivo. The F9 teratocarcinoma cell line is an in vitro model ...
Endele Max - - 2012
Functional heterogeneity within stem and progenitor cells has been shown to influence cell fate decisions. Similarly, intracellular signaling activated by external stimuli is highly heterogeneous and its spatiotemporal activity is linked to future cell behavior. To quantify these heterogeneous states and link them to future cell fates, it is important ...
Roussin Andre T - - 2012
It is becoming increasingly clear that the brain processes sensory stimuli differently according to whether they are passively or actively acquired, and these differences can be seen early in the sensory pathway. In the nucleus of the solitary tract (NTS), the first relay in the central gustatory neuraxis, a rich ...
Allen Jessica L - - 2012
Cells encounter physical cues such as extracellular matrix (ECM) stiffness in a microenvironment replete with biochemical cues. However, the mechanisms by which cells integrate physical and biochemical cues to guide cellular decision making are not well defined. Here we investigate mechanisms by which chondrocytes generate an integrated response to ECM ...
Farquhar Marilyn G - - 2012
In this perspective, I review the scientific career of George E. Palade, the man many consider to be the father of cell biology. Palade's scientific contributions spanned more than 50 years (from the late 1940s to 2001) and were amazingly diverse and fundamental. He is best known for his discovery ...
Zhang Luhui - - 2012
Electrode materials are key components for fiber solar cells, and when combined with active layers (for light absorption and charge generation) in appropriate ways, they enable design and fabrication of efficient and innovative device structures. Here, we apply carbon nanotube yarns as counter electrodes in combination with CdSe nanowire-grafted primary ...
Kandachar Vasundhara - - 2012
The Notch signaling pathway controls patterning and cell fate decisions during development in metazoans, and is associated with human diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and certain cancers. Studies over the last several years have revealed sophisticated regulation of both the membrane-bound Notch ...
Bhatia-Kiššová Ingrid - - 2012
This focus makes a case that mitophagy is not a straightforward process obeying simple rules. It is a complex process through which the cell gets rid of both damaged and healthy untainted mitochondria to adjust their amount, and in accordance with cellular energy requirements. Several aspects of mitophagy have been ...
Magnúsdóttir Erna E Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United - - 2012
Development of mammalian primordial germ cells (PGCs) presents a unique example of a cell fate specification event that is intimately linked with epigenetic reprogramming. Cell fate commitment is governed by transcription factors which, together with epigenetic regulators, instruct lineage choice in response to signalling cues. Similarly, the reversal of epigenetic ...
Solá Susana - - 2012
Emerging evidence suggests that apoptosis regulators and executioners may control cell fate, without involving cell death per se. Indeed, several conserved elements of apoptosis are integral components of terminal differentiation, which must be restrictively activated to assure differentiation efficiency, and carefully regulated to avoid cell loss. A better understanding of ...
Meyer-Hermann Michael M Department for Systems Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany. - - 2012
High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments. These have revealed cell migration patterns, asymmetric cell divisions, and cell-cell interaction characteristics, used here to develop a ...
Purvis Jeremy E JE Department of Systems Biology, Harvard Medical School, Boston, MA 02115, - - 2012
Cells transmit information through molecular signals that often show complex dynamical patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; in response to double-strand DNA breaks, it shows a series of repeated pulses. Using a computational model, we identified a sequence of precisely timed drug ...
Taghon Tom - - 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T ...
Li Meng Amy MA Division of Cellular and Developmental Biology, Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, CA, - - 2012
Emerging evidence suggests that microRNA (miRNA)-mediated post-transcriptional gene regulation plays an essential role in modulating embryonic stem (ES) cell pluripotency maintenance, differentiation, and reprogramming of somatic cells to an ES cell-like state. Investigations from ES cell-enriched miRNAs, such as mouse miR-290 cluster and human miR-302 cluster, and ES cell-depleted miRNAs ...
Pantazis Periklis - - 2012
There is a long-running controversy about how early cell fate decisions are made in the developing mammalian embryo. ( 1) (,) ( 2) In particular, it is controversial when the first events that can predict the establishment of the pluripotent and extra-embryonic lineages in the blastocyst of the pre-implantation embryo ...
Czirok Andras - - 2012
Vasculogenesis, the assembly of the first vascular network, is an intriguing developmental process that yields the first functional organ system of the embryo. In addition to being a fundamental part of embryonic development, vasculogenic processes also have medical importance. To explain the organizational principles behind vascular patterning, we must understand ...
Rinaldo Cinzia - - 2012
Failure in cytokinesis, the final step in cell division, by generating tetra- and polyploidization promotes chromosomal instability, a hallmark of cancer. Here we show that HIPK2, a kinase involved in cell fate decisions in development and response to stress, controls cytokinesis and prevents tetraploidization through its effects on histone H2B. ...
Smalley Matthew J MJ European Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK. - - 2012
Isolation of mammary epithelial subpopulations, including stem and progenitor cells, has become a standard technique in recent years. However, a number of methods and approaches for this have developed and the relative benefits of the different approaches, and the reason for their development, have not always been clear. Here, three ...
Peer Elad - - 2012
We present a novel hollow nano-needle array (NNA) device capable of simultaneously delivering diverse cargo into a group of cells in a culture over prolonged periods. The silica needles are fed by a common reservoir whose content can be replenished and modified in real time while maintaining contact with the ...
1 2 3 4 5 6 7 8 9 10 >