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Lv Huicheng H Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 404000, P.R. China ; Department of Orthopaedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. - - 2014
As the most common malignant primary bone tumor in childhood, osteosarcoma (OS) maintains a high recurrence, despite the significant improvements in the overall survival rate of high-grade OS patients during the recent decades. Therefore, a novel therapy strategy is required for OS treatment. Recently, various microRNAs (miRNAs or miRs) have ...
Nagy Dénes D Department of Physiology, Faculty of General Medicine, University of Debrecen, Nagyerdei krt 98, PO Box 22, 4012, Debrecen, - - 2014
TASK-3 (KCNK9 or K2P9.1) channels are thought to promote proliferation and/or survival of malignantly transformed cells, most likely by increasing their hypoxia tolerance. Based on our previous results that suggested mitochondrial expression of TASK-3 channels, we hypothesized that TASK-3 channels have roles in maintaining mitochondrial activity. In the present work ...
Zuo Yan Y Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX - - 2014
Net1 is a RhoA subfamily specific guanine nucleotide exchange factor that is overexpressed in human breast cancer and is required for breast cancer cell migration and invasion. However, the role of Net1 in normal mammary gland development or function has never been assessed. To understand the role of Net1 in ...
Unternaehrer Juli J JJ Division of Pediatric Hematology/Oncology, Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Harvard University, Cambridge, MA 02138, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: - - 2014
Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) paradoxically reduced, while overexpression enhanced, reprogramming efficiency in human cells and ...
Lee Byunghong - - 2014
We introduce a new class of molecular iodosalt compounds for application in next-generation solar cells. Unlike tin-based perovskite compounds CsSnI3 and CH3NH3SnI3 which have Sn in 2+ oxidation state and must be handled in inert atmosphere when fabricating solar cells, the Sn in the molecular iodosalt compounds is in the ...
Cobine Caroline Ann CA University of Nevada, Reno - - 2014
The effector cells and second messengers participating in nitrergic neuromuscular transmission (NMT) were investigated in the mouse internal anal sphincter (IAS). Protein expression of guanylate cyclase (GCα, GCβ) and cyclic GMP dependent protein kinase I (cGKI) were examined in cryostat sections with dual labeling immunohistochemical techniques in PDGFRα(+) cells, interstitial ...
Radde Brandie N - - 2014
Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated charcoal (DCC)-stripped fetal bovine serum (FBS)-containing medium ...
Im A-Rang - - 2014
Mitochondrial dysfunction has been implicated in neuronal apoptosis associated with neurodegenerative diseases such as Huntington's disease (HD). Animals that are administered 3-nitropropionic acid (3-NP), a mitochondrial toxin that specifically inhibits complex II of the mitochondrial electron transport chain, manifest HD-like symptoms. Psoralea corylifolia Linn seed extracts against 3-NP induced mitochondrial ...
Zatyka M M Department of Medical and Molecular Genetics, University of Birmingham, Birmingham, B15 2TT, - - 2014
Wolfram syndrome is an autosomal recessive disorder characterised by neurodegeneration and diabetes mellitus. The gene responsible for the syndrome (WFS1) encodes an endoplasmic reticulum (ER)-resident transmembrane protein that is involved in the regulation of the unfolded protein response, intracellular ion homeostasis, cyclic AMP production and regulation of insulin biosynthesis and ...
Tiwari Ankana A Indian Institute of Science, - - 2014
ESRRA functions as a transcription factor and regulates the expression of several genes, such as WNT11 and OPN. Upregulation of ESRRA has been reported in several cancers. However, the mechanism underlying its upregulation is unclear. Further, the reports regarding the role and regulation of ESRRA in oral squamous cell carcinoma ...
Ti Yunfan Y Department of Orthopedics of Jinling Hospital, School of Medicine, Nanjing University, 305 Zhongshan East Rd, Nanjing, 210002, - - 2014
Osteoclast is the only cell that can degrade bone tissue in vivo. Recent studies have shown the important role of cytoskeleton dynamics in osteolysis and the formation of podosome belt in osteoclasts. This process is regulated by the dynamic microtubule (MT) network. We treated osteoclast precursor cells Raw264.7 with low ...
Mansour Marc R MR Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Haematology, UCL Cancer Institute, University College London, London, - - 2014
Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independent activation of STAT5. We hypothesized that the reducing agent N-acetylcysteine (NAC), ...
Sørensen Belinda Halling BH University of - - 2014
Cisplatin resistance is a major challenge in the treatment of cancer and develops through reduced drug accumulation and an increased ability to avoid drug-induced cell damage, cell shrinkage and hence initiation of apoptosis. Uptake and release of the semi-essential amino acid taurine contribute to cell volume homeostasis and taurine has ...
Tulbah Alaa S AS Sydney University, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, Respiratory Technology , Sydney, NSW 2037 , Australia - - 2014
Objectives: This study focuses on the development of a dry powder inhaler (DPI) formulation of simvastatin (SV), and the effects of SV on the respiratory epithelium. Methods: Micronised SV samples were prepared by dry jet-milling. The long-term chemical stability and physicochemical properties of the formulations were characterised in terms of ...
Lee Ji Hae - - 2014
Dietary flavonoids have various biological functions. However, their cellular transport mechanisms are largely unknown. We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin. In qPCR analysis, MATE1 was highly expressed in the mouse liver ...
Jagannathan S S 1] The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH USA [2] Division of Hematology and Oncology; University of Cincinnati College of Medicine, Cincinnati, OH - - 2014
Evading apoptosis is a cancer hallmark that remains a serious obstacle in current treatment approaches. While proteasome inhibitors (PIs) have transformed management of multiple myeloma (MM), drug resistance emerges through induction of the aggresome+autophagy pathway as a compensatory protein clearance mechanism. Genome-wide profiling identified miRs differentially expressed in bortezomib-resistant myeloma ...
Nambiar Dhanya K DK Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. School of Life Sciences, Jawaharlal Nehru University, - - 2014
Prostate cancer (PCA) kills thousands of men every year, demanding additional approaches to better understand and target this malignancy. Recently, critical role of aberrant lipogenesis is highlighted in prostate carcinogenesis, offering a unique opportunity to target it to reduce PCA. Here, we evaluated efficacy and associated mechanisms of silibinin in ...
Wang Xiaolei X College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, - - 2014
Determination of intracellular bioactive species will afford beneficial information related to cell metabolism, signal transduction, cell function, and disease treatment. In this study, the electrochemically reduced graphene oxide modified carbon fiber microdisk electrode (ER-GOME) was used to be the detector of capillary zone electrophoresis-electrochemical detection and developed to detect glutathione ...
Kayastha Forum F Iladevi Cataract and IOL Research Centre, Gurukul road, Memnagar, Ahmedabad-380052, - - 2014
Lens epithelial cell proliferation, migration, and transdifferentiation are involved in the development of subcapsular cataracts and postoperative capsular opacification (PCO). PI3K/Akt pathway is involved in the proliferation and migration of lens epithelial cells. Andrographolide is the main bioactive component of Andrographis paniculata and is known to possess anti-proliferative and anti-migratory ...
Mane Shivshankar R - - 2014
Stimuli responsive polymeric nanocarrier (RCOP-2) functionalized with frontline anti tuberculosis drug (rifampicin) is demonstrated for the sustained release. Bioavailability of rifampicin is taken care by conjugating it through a hydrazone linker to the polymeric backbone. PEG motif is introduced in the copolymer architecture for the water solubility. Releasing retinal along ...
Kalve Shweta S Department of Biology, University of Antwerp, - - 2014
Variations in size and shape of multicellular organs depend on spatio-temporal regulation of cell division and expansion. Here, cell division and expansion rates were quantified relative to the three spatial axes in the first leaf pair of Arabidopsis thaliana. The results show striking differences in expansion rates: the expansion rate ...
Zhang Chang C http://orcid.org/0000-0003-1517-2377 University of - - 2014
Abscisic Acid (ABA) modulates root growth in plants grown under normal and stress conditions and can rescue the root growth defects of the Medicago truncatula lateral root-organ defective (latd) mutant. Here we demonstrate that Reactive Oxygen Species (ROS) function downstream of ABA in the regulation of root growth by controlling ...
Baïlo Nathalie - - 2014
Dictyostelium discoideum ACAP-A is an Arf-GTPase-activating protein involved in cytokinesis, cell migration and actin cytoskeleton dynamics. In mammalian cells, ACAP family members regulate endocytic protein trafficking. Here we explored the function of ACAP-A in the endocytic pathway of D. discoideum. In the absence of ACAP-A, reduced fusion efficacy of post-lysosomes ...
Yu Fu-Xiang FX Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang, - - 2014
Hepatic stellate cells (HSCs) play an important role in the process of liver fibrosis. In this study, we investigated the inhibitory effects of capsaicin on HSCs and liver fibrosis. Cultured HSCs were incubated with various concentrations of capsaicin. Cell proliferation was examined using a cell counting kit. Production of hydrogen ...
Hotz Birgit B Department of Surgery I, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, - - 2014
The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for metastasis. The aim of this study was to elucidate the effects of low-dose TRD on pancreatic cancer. Human pancreatic ...
Tang J J Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, - - 2014
Osteosarcoma (OS) is one of the most common primary malignant bone tumours of childhood and adolescence, and is characterized by high propensity for metastasis (specially to the lung), which is the main cause of death. However, molecular mechanisms underlying metastasis of OS are still poorly understood. Metadherin (MTDH) was identified ...
Chao Ming-Wei MW Department of BioScience Technology, Chung Yuan Christian University, Chungli, Taoyuan, Taiwan, 320; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Exposure to monocyclic aromatic alkylanilines (MAAs), namely 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA) and 3-ethylaniline (3-EA), was significantly and independently associated with bladder cancer incidence. 3,5-DMAP (3,5-dimethylaminophenol), a metabolite of 3,5-DMA, was shown to induce an imbalance in cytotoxicity cellular antioxidant/oxidant status, and DNA damage in mammalian cell lines. This study was ...
Zhang Wenchao W Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Obstetrics and Gynecology, Yangpu District Central Hospital, Shanghai, - - 2014
Myosin is involved in cell contraction and motility, but it is unclear whether it is involved in cell proliferation in uterine myoma. In this study therefore we aimed to explore the role of myosin in uterine myoma. Immunohistochemistry and real-time polymerase chain reaction were used to determine the expression of ...
McElroy Steven J SJ Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, - - 2014
Necrotizing enterocolitis (NEC) affects up to 10% of premature infants, has a mortality of 30%, and can leave surviving patients with significant morbidity. Neuregulin-4 (NRG4) is an ErbB4-specific ligand that promotes epithelial cell survival. Thus, this pathway could be protective in diseases such as NEC, in which epithelial cell death ...
Mondal Jesmin J Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani-741235, - - 2014
Use of cisplatin, a conventional anticancer drug, is restricted because it generates strong hepatotoxicity by accumulating in liver. Therefore its anticancer potential can only be fully exploited if its own toxicity is considerably reduced. Towards this goal, ethanolic extract of the plant, Boldo (Peumus boldus), known for its antihepatotoxic effects, ...
Fernández Diego A DA Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Campus Universitario, 27002 Lugo, - - 2014
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in ecological and human risk. In order to reach the bloodstream ...
Lou Chenghua C Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, - - 2014
Nuclear factor-κB (NF-κB) activation has been implicated not only in carcinogenesis but also in cancer cell invasion and metastatic process; therefore, targeting the NF-κB pathway is an attractive strategy for controlling meta-stasis. Amongst 56 chemically defined compounds derived from natural products, we have identified a new phytochemical compound Hirsutine, which ...
Liu Ruihua R State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, 300071, - - 2014
Many ecosystems are currently co-contaminated with pesticides and heavy metals, such as chlorpyrifos and cadmium. A promising strategy to remediate mixed chlorpyrifos-cadmium-contaminated sites is the use of chlorpyrifos-degrading bacteria endowed with cadmium removal capabilities. In this work, a gene coding for synthetic phytochelatins (EC20) with high cadmium-binding capacity was introduced ...
Tran Tuan Hiep TH College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyeongsan 712-749, South - - 2014
Hyaluronic acid (HA)-decorated solid lipid nanoparticles (SLNs) were developed for tumor-targeted delivery of vorinostat (VRS), a histone deacetylase inhibitor. HA, a naturally occurring polysaccharide, which specifically binds to the CD44 receptor, was coated on a cationic lipid core through electrostatic interaction. After the optimization process, HA-coated VRS-loaded SLNs (HA-VRS-SLNs) were ...
Bjelic Maja M MM Reproductive Endocrinology and Signaling Group, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, - - 2014
This study systematically evaluates the effects of androgen receptor (AR) blockade on molecular events in Leydig cells. Results showed that intramuscular administration of testosterone-enanthate, at clinically relevant dose, decreased testosterone in interstitial fluid and Leydig cells from adult rats. AR-blocker (Androcur) prevented this effect and testosterone-reduced Leydig cells steroidogenic capacity/activity. ...
Sun Li L State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Haidian, Beijing 100085, P.R. - - 2014
Chlorpyrifos (CPF) is commonly used for agricultural and domestic applications, and its contamination is widely detected in environmental media, and in a broad spectrum of field crops, fruits and vegetables. CPF exposure causes many adverse effects on human health including hepatoxicity, neurotoxicity and endocrine disruption. However, few studies have been ...
Ruiz-Garcia Yolanda Y The Australian Wine Research Institute, PO Box 197, Glen Osmond 5064, SA, Australia; Food Science and Technology Department, Faculty of Veterinary Science, University of Murcia, Campus de Espinardo, 30071 Murcia, - - 2014
Cell wall material was isolated from two Vitis vinifera grape varieties, Cabernet Sauvignon and Shiraz, following a buffered phenol extraction method. Using sequential fractionation in chelating agent, then increasing the molarity of aqueous potassium hydroxide, polysaccharide classes were selectively extracted from cell walls to produce fractions of defined polysaccharide composition. ...
Chen Wen W School of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China ; School of Pharmacy, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Reigion, - - 2014
Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell growth. In this study, amino-functionalized ethylenediamine-treated multi-walled carbon nanotubes were used to prepare carbon nanotubes-nerve growth factor complexes by non-covalent ...
Hoyer Patricia B PB The University of Arizona, College of Medicine, Department of Physiology , 1501 N. Campbell Ave, Tucson AZ 85724 , USA +1 520 626 6688 ; +1 520 626 2382 ; - - 2014
Introduction: Damage caused by xenobiotic compounds to the ovaries is a subject of concern because of their critical role in reproduction. Female mammals are born with a finite number of germ cells (oocytes) encased in primordial follicles. Xenobiotic-induced damage to primordial follicles can result in early ovarian failure (premature menopause). ...
Franklin Robin J M RJ Wellcome Trust-MRC Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, United - - 2014
Amongst neurological diseases, multiple sclerosis (MS) presents an attractive target for regenerative medicine. This is because the primary pathology, the loss of myelin-forming oligodendrocytes, can be followed by a spontaneous and efficient regenerative process called remyelination. While cell transplantation approaches have been explored as a means of replacing lost oligodendrocytes, ...
Chandra V V Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, - - 2014
Endometrial hyperplasia is a precursor to the most common gynecologic cancer diagnosed in women. Apart from estrogenic induction, aberrant activation of the Wnt/β-catenin signal is well known to correlate with endometrial hyperplasia and its carcinoma. The benzopyran compound 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo (b) pyran(K-1), a potent antiestrogenic agent, has been shown to have ...
Gnanapragassam Vinayaga S VS Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, Halle (Saale), - - 2014
Sialic acids (Sia) represent negative-charged terminal sugars on most glycoproteins and glycolipids on the cell surface of vertebrates. Aberrant expression of tumor associated sialylated carbohydrate epitopes significantly increases during onset of cancer. Since Sia contribute towards cell migration ( =  metastasis) and to chemo- and radiation resistance. Modulation of cellular Sia ...
Brahmachari Sayanti S Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata, - - 2014
The present article reports the development of soft nanohybrids comprising of single walled carbon nanotube (SWCNT) included silver nanoparticles (AgNPs) having superior antibacterial property. In this regard aqueous dispersing agent of carbon nanotube (CNT) containing a silver ion reducing unit was synthesised by the inclusion of tryptophan and tyrosine within ...
Touret Franck - - 2014
The endosymbiotic bacteria of the genus Wolbachia are present in most insects and are maternally transmitted through the germline. Moreover, these intracellular bacteria exert antiviral activity against insect RNA viruses, as in Drosophila melanogaster, which could explain the prevalence of Wolbachia bacteria in natural populations. Wolbachia is maternally transmitted in ...
Lin Jen-Jie JJ Graduate Institute of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 91202, Taiwan. - - 2014
Cancer metastasis is one of the major causes of death in cancer. An active compound, 11-epi-sinulariolide acetate (11-epi-SA), isolated from the cultured soft coral Sinularia flexibilis has been examined for potential anti-cell migration and invasion effects on hepatocellular carcinoma cells (HCC). However, the molecular mechanism of anti-migration and invasion by ...
Hirayama Masatoshi - - 2013
: Current approaches for the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs to replace lost or damaged organs that result from disease, injury, or ...
Hansen Dave - - 2013
The C. elegans germ line has emerged as an important model for -understanding how a stem cell population is maintained throughout the life of the animal while still producing the gametes necessary for propagation of the species. The stem cell population in the adult hermaphrodite is relatively large, with stem ...
Kadam Shilpa D SD Neuroscience Laboratory, Hugo W Moser Research Institute ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
Auto antibodies found in the mothers of children with autistic disorder (MCAD) when passively transferred to pregnant mice cause behavioral alterations in juvenile and adult offspring. The goal of this study was to identify whether intraperitoneal injection of MCAD-IgG during gestation affected postnatal cell proliferation and survival in P7 offspring. ...
Prockop Darwin J - - 2012
A recent publication by Phinney and his associates ( 1 ) has presented a discovery for which the field of cell biology has been waiting for more than half a century: a protocol that makes it possible to expand mouse cells in culture without the cells spontaneously transforming. Amazing though ...
Baskin Tobias I - - 2012
The extracellular matrix is constructed beyond the plasma membrane, challenging mechanisms for its control by the cell. In plants, the cell wall is highly ordered, with cellulose microfibrils aligned coherently over a scale spanning hundreds of cells. To a considerable extent, deploying aligned microfibrils determines mechanical properties of the cell ...
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