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D Angelo Daniela - - 2014
Development of resistance to conventional drugs and novel biological agents often impair long-term chemotherapy. HMGA gene overexpression is often associated with antineoplastic drug resistance and reduced survival. Inhibition of HMGA expression in thyroid cancer cells reduces levels of ATM protein, the main cellular sensor of DNA damage, and enhances cellular ...
Lee Hyunseung H University of Texas Health Science Center at San Antonio, United - - 2014
Chronic exposure of UV radiation can contribute to the development of skin cancer by promoting PTK signaling. Studies show that exposure to UV radiation increases the ligand-independent activation of PTKs and induces PTP inactivation. In the present work, we report that TC-PTP activity is stimulated during the initial response to ...
Asare George Awuku GA University of Ghana, Accra, Ghana - - 2014
Background. Annona muricata L. has been reported to possess antitumor and antiproliferative properties. Not much work has been done on its effect on BPH-1 cell lines, and no in vivo studies targeting the prostate organ exist. The study determined the effect of A muricata on human BPH-1 cells and prostate ...
Zanotti Kimberly J KJ Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224; - - 2014
Mammalian ATPase family AAA domain-containing protein 5 (ATAD5) and its yeast homolog enhanced level of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly synthesized DNA. Prior work in HeLa and yeast cells showed that a decrease in ATAD5 protein levels resulted in accumulation of chromatin-bound ...
Teerds Katja J KJ Department of Animal Sciences, Human and Animal Physiology, Wageningen University, De Elst 1, 6709 WD Wageningen, The - - 2014
Disruption of normal fetal development can influence functioning of organs and cells in adulthood. Circumstantial evidence suggests that subtle reductions in fetal androgen production may be the cause of adult male reproductive disorders due to reduced testosterone production. The mechanisms through which these fetal events affect adult testosterone levels are ...
Buendia Izaskun - - 2014
We have investigated the protective effects of ITH91/IQM157, a hybrid of melatonin and N,N-dibenzyl(N-methyl)amine, in an in vitro model of AD-like pathology that combines amyloid beta (Aβ) and tau hyperphosphorylation induced by okadaic acid (OA), in the human neuroblastoma cell line SH-SY5Y. Combination of sub-toxic concentrations of Aβ and OA ...
Kido Natsumi N Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, 980-8578, - - 2014
Poales (represented by rice [Oryza sativa L.]) in angiosperms and Equisetum (horsetails) in Pteridophytes are two major groups of heavy silicon (Si) accumulators. In rice, Si is polymerized preferentially in the epidermal cell wall, forming Si-cuticle double layers beneath the cuticle. This Si layer is thought to exert various beneficial ...
Groneberg Dieter D Physiologisches Institut I, Universität Würzburg, Würzburg, - - 2014
Esophageal achalasia is a disease known to result from reduced relaxation of the lower esophageal sphincter. Nitric oxide (NO) is one of the main inhibitory transmitters. NO-sensitive guanylyl cyclase (NO-GC) acts as the key target of NO and, by the generation of cGMP, mediates nitrergic relaxation in the lower esophageal ...
Hahm Sahng-Wook SW 1 Institute of Life Science and Natural Resources, College of Life Sciences and Biotechnology, Korea University , Seoul, - - 2014
Abstract In this study, we found that the total polyphenol and ascorbic acid levels in the fruit of Opuntia humifusa are higher than those in other parts of the plant. We further hypothesized that antioxidants in O. humifusa might affect the growth or survival of cancer cells. Hexane extracts of ...
Lv Huicheng H Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 404000, P.R. China ; Department of Orthopaedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. - - 2014
As the most common malignant primary bone tumor in childhood, osteosarcoma (OS) maintains a high recurrence, despite the significant improvements in the overall survival rate of high-grade OS patients during the recent decades. Therefore, a novel therapy strategy is required for OS treatment. Recently, various microRNAs (miRNAs or miRs) have ...
Kim Dae-Hwan DH Energy Research Division, Daegu Gyeongbuk Institute of Science & Technology, 333, Techno jungang-daero, Hyeonpung-myeon, Dalseong-gun, Daegu 711-873, Republic of Korea. imromy@khu.ac.kr - - 2014
A high-quality Sb2S3 thin-absorber with controllable thickness was reproducibly formed by atomic layer deposition (ALD) technique. Compared with conventional chemical bath deposition (CBD), the Sb2S3 absorber deposited by ALD did not contain oxide or oxygen impurities and showed a very uniform thickness of Sb2S3 absorbers formed on a rough surface ...
Wang YouPing - - 2014
AML with Mt NPM1 has relatively good responses to induction therapy. However, a proportion of NPMc+ AML cells cannot be cleared by conventional treatments. Therefore, we determined the therapeutic efficacy of deguelin that has demonstrated extensive biological activity with low toxicity. We previously reported that deguelin selectively reduces Mt NPM1, ...
Gasparini Nicola - - 2014
The replacement of common fullerene derivatives with neat-C70 could be an effective approach to restrain the costs of organic photovoltaics and increase their sustainability. In this study, bulk-heterojunction solar cells made of neat-C70 and low energy-gap conjugated polymers, PTB7 and PCDTBT, are thoroughly investigated and compared. Upon replacing PC70BM with ...
Kazami T T Department of Molecular Diagnosis (F8), Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, - - 2014
Most human cancers show chromosomal instability (CIN), but the precise mechanisms remain uncertain. Annexin A2 is frequently overexpressed in human cancers, and its relationship to tumorigenesis is poorly understood. We found that annexin A2 is overexpressed in the nuclei of CIN cells compared with cells with microsatellite instability (MIN). Ectopic ...
Nakamura Takashi - - 2014
The basal layer of the epidermis contains stem cells and transit amplifying (TA) cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number of molecules have been identified as regulators for this process including p63 and Notch1. However, little is known about the mechanisms ...
Ainger Stephen A SA Institute for Molecular Bioscience, Melanogenix Group, The University of Queensland, Brisbane, Qld, 4072, - - 2014
Dopachrome tautomerase (DCT) is involved in the formation of the photoprotective skin pigment eumelanin, and has also been shown to have a role in response to apoptotic stimuli and oxidative stress. The effect of DCT on UVR DNA damage responses and survival pathways in human melanocytic cells was examined by ...
Nagy Dénes D Department of Physiology, Faculty of General Medicine, University of Debrecen, Nagyerdei krt 98, PO Box 22, 4012, Debrecen, - - 2014
TASK-3 (KCNK9 or K2P9.1) channels are thought to promote proliferation and/or survival of malignantly transformed cells, most likely by increasing their hypoxia tolerance. Based on our previous results that suggested mitochondrial expression of TASK-3 channels, we hypothesized that TASK-3 channels have roles in maintaining mitochondrial activity. In the present work ...
Zuo Yan Y Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX - - 2014
Net1 is a RhoA subfamily specific guanine nucleotide exchange factor that is overexpressed in human breast cancer and is required for breast cancer cell migration and invasion. However, the role of Net1 in normal mammary gland development or function has never been assessed. To understand the role of Net1 in ...
Unternaehrer Juli J JJ Division of Pediatric Hematology/Oncology, Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Harvard University, Cambridge, MA 02138, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: - - 2014
Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that knockdown (KD) of the epithelial-to-mesenchymal transition (EMT) factor SNAI1 (SNAIL) paradoxically reduced, while overexpression enhanced, reprogramming efficiency in human cells and ...
Lee Byunghong - - 2014
We introduce a new class of molecular iodosalt compounds for application in next-generation solar cells. Unlike tin-based perovskite compounds CsSnI3 and CH3NH3SnI3 which have Sn in 2+ oxidation state and must be handled in inert atmosphere when fabricating solar cells, the Sn in the molecular iodosalt compounds is in the ...
Cobine Caroline Ann CA University of Nevada, Reno - - 2014
The effector cells and second messengers participating in nitrergic neuromuscular transmission (NMT) were investigated in the mouse internal anal sphincter (IAS). Protein expression of guanylate cyclase (GCα, GCβ) and cyclic GMP dependent protein kinase I (cGKI) were examined in cryostat sections with dual labeling immunohistochemical techniques in PDGFRα(+) cells, interstitial ...
Radde Brandie N - - 2014
Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated charcoal (DCC)-stripped fetal bovine serum (FBS)-containing medium ...
Im A-Rang - - 2014
Mitochondrial dysfunction has been implicated in neuronal apoptosis associated with neurodegenerative diseases such as Huntington's disease (HD). Animals that are administered 3-nitropropionic acid (3-NP), a mitochondrial toxin that specifically inhibits complex II of the mitochondrial electron transport chain, manifest HD-like symptoms. Psoralea corylifolia Linn seed extracts against 3-NP induced mitochondrial ...
Zatyka M M Department of Medical and Molecular Genetics, University of Birmingham, Birmingham, B15 2TT, - - 2014
Wolfram syndrome is an autosomal recessive disorder characterised by neurodegeneration and diabetes mellitus. The gene responsible for the syndrome (WFS1) encodes an endoplasmic reticulum (ER)-resident transmembrane protein that is involved in the regulation of the unfolded protein response, intracellular ion homeostasis, cyclic AMP production and regulation of insulin biosynthesis and ...
Tiwari Ankana A Indian Institute of Science, - - 2014
ESRRA functions as a transcription factor and regulates the expression of several genes, such as WNT11 and OPN. Upregulation of ESRRA has been reported in several cancers. However, the mechanism underlying its upregulation is unclear. Further, the reports regarding the role and regulation of ESRRA in oral squamous cell carcinoma ...
Ti Yunfan Y Department of Orthopedics of Jinling Hospital, School of Medicine, Nanjing University, 305 Zhongshan East Rd, Nanjing, 210002, - - 2014
Osteoclast is the only cell that can degrade bone tissue in vivo. Recent studies have shown the important role of cytoskeleton dynamics in osteolysis and the formation of podosome belt in osteoclasts. This process is regulated by the dynamic microtubule (MT) network. We treated osteoclast precursor cells Raw264.7 with low ...
Mansour Marc R MR Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Haematology, UCL Cancer Institute, University College London, London, - - 2014
Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independent activation of STAT5. We hypothesized that the reducing agent N-acetylcysteine (NAC), ...
Sørensen Belinda Halling BH University of - - 2014
Cisplatin resistance is a major challenge in the treatment of cancer and develops through reduced drug accumulation and an increased ability to avoid drug-induced cell damage, cell shrinkage and hence initiation of apoptosis. Uptake and release of the semi-essential amino acid taurine contribute to cell volume homeostasis and taurine has ...
Tulbah Alaa S AS Sydney University, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, Respiratory Technology , Sydney, NSW 2037 , Australia - - 2014
Objectives: This study focuses on the development of a dry powder inhaler (DPI) formulation of simvastatin (SV), and the effects of SV on the respiratory epithelium. Methods: Micronised SV samples were prepared by dry jet-milling. The long-term chemical stability and physicochemical properties of the formulations were characterised in terms of ...
Sutton Selina K SK Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, Sydney, - - 2014
High basal or induced expression of the tripartite motif protein, TRIM16, leads to reduce cell growth and migration of neuroblastoma and skin squamous cell carcinoma cells. However, the role of TRIM16 in melanoma is currently unknown. TRIM16 protein levels were markedly reduced in human melanoma cell lines, compared with normal ...
Lee Ji Hae - - 2014
Dietary flavonoids have various biological functions. However, their cellular transport mechanisms are largely unknown. We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and has a high affinity for quercetin. In qPCR analysis, MATE1 was highly expressed in the mouse liver ...
Jagannathan S S 1] The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH USA [2] Division of Hematology and Oncology; University of Cincinnati College of Medicine, Cincinnati, OH - - 2014
Evading apoptosis is a cancer hallmark that remains a serious obstacle in current treatment approaches. While proteasome inhibitors (PIs) have transformed management of multiple myeloma (MM), drug resistance emerges through induction of the aggresome+autophagy pathway as a compensatory protein clearance mechanism. Genome-wide profiling identified miRs differentially expressed in bortezomib-resistant myeloma ...
Nambiar Dhanya K DK Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. School of Life Sciences, Jawaharlal Nehru University, - - 2014
Prostate cancer (PCA) kills thousands of men every year, demanding additional approaches to better understand and target this malignancy. Recently, critical role of aberrant lipogenesis is highlighted in prostate carcinogenesis, offering a unique opportunity to target it to reduce PCA. Here, we evaluated efficacy and associated mechanisms of silibinin in ...
Wang Xiaolei X College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, - - 2014
Determination of intracellular bioactive species will afford beneficial information related to cell metabolism, signal transduction, cell function, and disease treatment. In this study, the electrochemically reduced graphene oxide modified carbon fiber microdisk electrode (ER-GOME) was used to be the detector of capillary zone electrophoresis-electrochemical detection and developed to detect glutathione ...
Kayastha Forum F Iladevi Cataract and IOL Research Centre, Gurukul road, Memnagar, Ahmedabad-380052, - - 2014
Lens epithelial cell proliferation, migration, and transdifferentiation are involved in the development of subcapsular cataracts and postoperative capsular opacification (PCO). PI3K/Akt pathway is involved in the proliferation and migration of lens epithelial cells. Andrographolide is the main bioactive component of Andrographis paniculata and is known to possess anti-proliferative and anti-migratory ...
Mane Shivshankar R - - 2014
Stimuli responsive polymeric nanocarrier (RCOP-2) functionalized with frontline anti tuberculosis drug (rifampicin) is demonstrated for the sustained release. Bioavailability of rifampicin is taken care by conjugating it through a hydrazone linker to the polymeric backbone. PEG motif is introduced in the copolymer architecture for the water solubility. Releasing retinal along ...
Kalve Shweta S Department of Biology, University of Antwerp, - - 2014
Variations in size and shape of multicellular organs depend on spatio-temporal regulation of cell division and expansion. Here, cell division and expansion rates were quantified relative to the three spatial axes in the first leaf pair of Arabidopsis thaliana. The results show striking differences in expansion rates: the expansion rate ...
Zhang Chang C http://orcid.org/0000-0003-1517-2377 University of - - 2014
Abscisic Acid (ABA) modulates root growth in plants grown under normal and stress conditions and can rescue the root growth defects of the Medicago truncatula lateral root-organ defective (latd) mutant. Here we demonstrate that Reactive Oxygen Species (ROS) function downstream of ABA in the regulation of root growth by controlling ...
Baïlo Nathalie - - 2014
Dictyostelium discoideum ACAP-A is an Arf-GTPase-activating protein involved in cytokinesis, cell migration and actin cytoskeleton dynamics. In mammalian cells, ACAP family members regulate endocytic protein trafficking. Here we explored the function of ACAP-A in the endocytic pathway of D. discoideum. In the absence of ACAP-A, reduced fusion efficacy of post-lysosomes ...
Yu Fu-Xiang FX Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, Zhejiang, - - 2014
Hepatic stellate cells (HSCs) play an important role in the process of liver fibrosis. In this study, we investigated the inhibitory effects of capsaicin on HSCs and liver fibrosis. Cultured HSCs were incubated with various concentrations of capsaicin. Cell proliferation was examined using a cell counting kit. Production of hydrogen ...
Hotz Birgit B Department of Surgery I, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, - - 2014
The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for metastasis. The aim of this study was to elucidate the effects of low-dose TRD on pancreatic cancer. Human pancreatic ...
Tang J J Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, - - 2014
Osteosarcoma (OS) is one of the most common primary malignant bone tumours of childhood and adolescence, and is characterized by high propensity for metastasis (specially to the lung), which is the main cause of death. However, molecular mechanisms underlying metastasis of OS are still poorly understood. Metadherin (MTDH) was identified ...
Chao Ming-Wei MW Department of BioScience Technology, Chung Yuan Christian University, Chungli, Taoyuan, Taiwan, 320; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, - - 2014
Exposure to monocyclic aromatic alkylanilines (MAAs), namely 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA) and 3-ethylaniline (3-EA), was significantly and independently associated with bladder cancer incidence. 3,5-DMAP (3,5-dimethylaminophenol), a metabolite of 3,5-DMA, was shown to induce an imbalance in cytotoxicity cellular antioxidant/oxidant status, and DNA damage in mammalian cell lines. This study was ...
Zhang Wenchao W Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Obstetrics and Gynecology, Yangpu District Central Hospital, Shanghai, - - 2014
Myosin is involved in cell contraction and motility, but it is unclear whether it is involved in cell proliferation in uterine myoma. In this study therefore we aimed to explore the role of myosin in uterine myoma. Immunohistochemistry and real-time polymerase chain reaction were used to determine the expression of ...
McElroy Steven J SJ Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, - - 2014
Necrotizing enterocolitis (NEC) affects up to 10% of premature infants, has a mortality of 30%, and can leave surviving patients with significant morbidity. Neuregulin-4 (NRG4) is an ErbB4-specific ligand that promotes epithelial cell survival. Thus, this pathway could be protective in diseases such as NEC, in which epithelial cell death ...
Mondal Jesmin J Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani-741235, - - 2014
Use of cisplatin, a conventional anticancer drug, is restricted because it generates strong hepatotoxicity by accumulating in liver. Therefore its anticancer potential can only be fully exploited if its own toxicity is considerably reduced. Towards this goal, ethanolic extract of the plant, Boldo (Peumus boldus), known for its antihepatotoxic effects, ...
Fernández Diego A DA Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Campus Universitario, 27002 Lugo, - - 2014
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in ecological and human risk. In order to reach the bloodstream ...
Lou Chenghua C Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, - - 2014
Nuclear factor-κB (NF-κB) activation has been implicated not only in carcinogenesis but also in cancer cell invasion and metastatic process; therefore, targeting the NF-κB pathway is an attractive strategy for controlling meta-stasis. Amongst 56 chemically defined compounds derived from natural products, we have identified a new phytochemical compound Hirsutine, which ...
Liu Ruihua R State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, 300071, - - 2014
Many ecosystems are currently co-contaminated with pesticides and heavy metals, such as chlorpyrifos and cadmium. A promising strategy to remediate mixed chlorpyrifos-cadmium-contaminated sites is the use of chlorpyrifos-degrading bacteria endowed with cadmium removal capabilities. In this work, a gene coding for synthetic phytochelatins (EC20) with high cadmium-binding capacity was introduced ...
Tran Tuan Hiep TH College of Pharmacy, Yeungnam University, 214-1, Dae-Dong, Gyeongsan 712-749, South - - 2014
Hyaluronic acid (HA)-decorated solid lipid nanoparticles (SLNs) were developed for tumor-targeted delivery of vorinostat (VRS), a histone deacetylase inhibitor. HA, a naturally occurring polysaccharide, which specifically binds to the CD44 receptor, was coated on a cationic lipid core through electrostatic interaction. After the optimization process, HA-coated VRS-loaded SLNs (HA-VRS-SLNs) were ...
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