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Zhu Dan - - 2014
BackgroundMicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non¿small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-224 in NSCLC tumorigenesis and development.MethodsUsing real-time quantitative RT-PCR, ...
Mao Xiaona X Center for Translational Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. - - 2014
Epithelial cells possess apical‑basal polarity and loss of epithelial cell polarity contributes to tumorigenesis and cancer progression. The Crumbs (CRB) polarity protein plays a crucial role in epithelial polarity maintenance, apical membrane formation, and tissue morphogenesis. Although evidence is increasing on involvement of deregulated polarity proteins in cancers, little is currently ...
Jung Jae Hun JH Department of Applied Chemistry, College of Applied Science, Kyung Hee University, Yongin, Republic of - - 2014
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) such as gefitinib are one of gold standard treatment options for non-small-cell lung cancer (NSCLC) patients, which eventually fail due to the acquired resistance and relapse because of the development of secondary activating mutations such as T790M in EGFR. Predicting chemo-responsiveness ...
Marschalkó M M Department of Dermatology, Venerology and Dermatooncology, Semmelweis University, Faculty of Medicine, Budapest, - - 2014
Folliculotropic mycosis fungoides (FMF) represents a variant of MF characterized by hair follicle invasion of mature, CD4-positive small lymphoid cells with cerebriform nuclei. The disease displays resistance to standard treatment modalities and has an unfavourable course. Clinical analysis of 17 patients with FMF collected between 2005 and 2012, investigation of ...
Yang Tian T Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, - - 2014
STK33 has been reported to play an important role in cancer cell proliferation. We investigated the role of STK33 in hepatocellular carcinoma (HCC) and its underlying mechanisms. 251 patients with HCC were analysed for association between STK33 expression and clinical stage and survival rate. Tamoxifen (TAM)-inducible, hepatocyte-specific STK33 transgenic and ...
Maddur Mohan S MS Institut National de la Santé et de la Recherche Médicale Unité 1138, 75006, Paris, - - 2014
Guillain-Barré syndrome (GBS) is an acute, autoimmune inflammatory disorder of peripheral nervous system characterized by a severe functional motor weakness. Treatment with intravenous immunoglobulin (IVIg) is one of the approved and preferred therapeutic strategies for GBS. However, the mechanisms underlying the therapeutic benefit with IVIg in GBS are not completely ...
Kersseboom Simone S Department of Internal Medicine (S.K., W.E.V., E.C.H.F., R.P.P., T.J.V.) and Rotterdam Thyroid Center (S.K., W.E.V., R.P.P., T.J.V.), Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands; Leibniz Institute for Age Research/Fritz Lipmann Institute (S.H., J.C., H.H.), Jena, Germany; Inserm (C.V.-B.), Unité Mixte de Recherche (UMR) 1103, and Centre National de la Recherche Scientifique (C.V.-B.), UMR6293, F-63001 Clermont-Ferrand, France; Clermont Université (C.V.-B.), Université d'Auvergne, Laboratoire GReD, BP 10448, F-63000 Clermont-Ferrand, France; and Leibniz Research Institute for Environmental Medicine (J.C., H.H.), Düsseldorf, - - 2014
Monocarboxylate transporter 8 (MCT8) transports thyroid hormone (TH) across the plasma membrane. Mutations in MCT8 result in the Allan-Herndon-Dudley syndrome, comprising severe psychomotor retardation and elevated serum T3 levels. Because the neurological symptoms are most likely caused by a lack of TH transport into the central nervous system, the administration ...
Silber Paulo C PC Cornea and External Disease Service, Department of Ophthalmology, Federal University of São Paulo, São Paulo - - - 2014
Reconstruction of the ocular surface is challenging. As an alternative to mucosal and limbal epithelial, we study the feasibility of cultivated human conjunctival epithelial (HCjE) cells of patients with total limbal stem cell deficiency (LSCD). We studied superior forniceal conjunctival biopsies harvested from 9 living donors with total LSCD of ...
Lu Guo-Dong GD Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Public Health, Guangxi Medical University, - - 2014
C/EBPalpha plays an essential role in cellular differentiation, growth and energy metabolism. Here, we investigate the correlation between C/EBPalpha and hepatocellular carcinoma (HCC) patient outcomes, and how C/EBPalpha protects cells against energy starvation. C/EBPalpha protein expression was increased in the majority of HCCs examined (191 pairs) compared with adjacent non-tumor ...
Larráyoz Ignacio M IM Angiogenesis Study Group, Center for Biomedical Research of La Rioja (CIBIR), Logrono, 26006, - - 2014
Purpose: To understand the differential response to doxycycline observed in a previous clinical trial between patients with Caucasian versus Hispanic origin. Methods: Primary cultures were established from pterygia excised from male Caucasian (n=3) and Hispanic (n=6) patients. The response of these cells to doxycycline was tested in a toxicicty assay. ...
Underwood Timothy J TJ Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building, Southampton General Hospital, Tremona Road, Southampton, UK, SO16 - - 2014
Interactions between cancer cells and cancer-associated fibroblasts (CAF) play an important role in tumour development and progression. In this study we investigated the functional role of CAF in oesophageal adenocarcinoma (EAC). We used immunochemistry to analyse a cohort of EAC patients (183 patients) for CAF markers related to disease mortality. ...
Feng Yong Y Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, 02114, Boston, Massachusetts; Department of Orthopaedic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie Fang Avenue, 430022, Wuhan, - - 2014
Osteosarcoma is the most common type primary malignant tumor of bone. Patients with regional osteosarcoma are routinely treated with surgery and chemotherapy. In addition, many patients with metastatic or recurrent osteosarcoma show poor prognosis with current chemotherapy agents. Therefore, it is important to improve the general condition and the overall ...
Jie Li-Gang LG Department of Chinese Medicine, Guangzhou General Hospital of Guangzhou Command of PLA, Guangzhou, Guangdong 510010, P.R. - - 2014
Cysteine‑rich angiogenic inducer 61 (Cyr61) is a novel molecule that has been shown to be increased in the synovial tissues of patients with rheumatoid arthritis (RA). The present study was conducted in order to investigate the role of Cyr61 in the pathogenesis of RA. A human genome‑wide gene assay was used to ...
Unizony Sebastian S Massachusetts General Hospital, Boston, Massachusetts, - - 2014
Objectives: Conceptualized as possible surrogates for regulatory B-cells (Bregs), we aimed to determine the utility of CD5(+) B-cells as biomarkers in ANCA-associated vasculitis (AAV) Methods: Absolute and relative (%) numbers of CD5(+) B-cells (explanatory variables) were measured longitudinally during 18 months in 197 patients randomized to receive rituximab (RTX) or ...
Inamura Kentaro K Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA, - - 2014
Colorectal carcinoma (CRC) represents a group of histopathologically and molecularly heterogeneous diseases, which may contain signet-ring cell component and/or mucinous component to a varying extent under pathology assessment. However, little is known about the prognostic significance of those components, independent of various tumor molecular features. Utilizing a molecular pathological epidemiology ...
Stinson Sally E SE Institute of Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United - - 2014
The D prostanoid receptor 2 (DP2; also known as chemoattractant receptor-homologous molecule expressed on TH2 cells) is implicated in the pathogenesis of asthma, but its expression within bronchial biopsy specimens is unknown. We sought to investigate the bronchial submucosal DP2 expression in asthmatic patients and healthy control subjects and to ...
Yokoyama Koji K Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, - - 2014
Objective. Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin (IL)-1β. However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore occur independently of the NLRP3 inflammasome. This study investigated ...
Schwarz Nele N UCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, - - 2014
Mutations in the RP2 gene lead to a severe form of X-linked retinitis pigmentosa. RP2 patients frequently present with nonsense mutations and no treatments are currently available to restore RP2 function. In this study, we reprogrammed fibroblasts from an RP2 patient carrying the nonsense mutation c.519C>T (p.R120X) into induced pluripotent ...
Gong Zhi-Hua ZH Department of Oncology, Cancer Institute of People's Liberation Army, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. - - 2014
Superior vena cava (SVC) syndrome results from clear cell renal cell carcinoma and is a challenge in clinical practice due to its pathological complexity and a lack of research data. The current study presents a 49-year-old female with symptoms of exertional dyspnea and increased fatigue, which had persisted for 15 ...
Li H-X HX Department of Hematology and Oncology, Children's Hospital of Zhengzhou, Zhengzhou, China. - - 2014
Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. Despite aggressive therapy, survival outcomes remain unsatisfactory, especially for patients with metastatic disease or patients with a poor chemotherapy response. Previous study founds inosine 5'-monophosphate dehydrogenase type II (IMPDH2) was an independent prognostic factor and observed ...
Kim Moo Hyun MH Department of Cardiology, College of Medicine, Dong-A University, Busan, Korea; Regional Clinical Trial Center, Dong-A University Hospital, Busan, - - 2014
Recently, we reported the properties of CD31-expressing cells in healthy individuals. However, the characteristics of CD31-expressing cells derived from coronary artery disease (CAD) patients remain unknown. This study aimed to investigate the relationship between circulating CD31(+) cells and CAD as well as their biological characteristics. Analysis with flow cytometry revealed ...
Abdouh Mohamed - - 2014
BackgroundHuman cancer cells can transfer signaling molecules to neighboring and distant cells predisposing them to malignant transformation. This process might contribute to tumor progression and invasion through delivery of oncogenes or inhibitors of tumor suppressor genes, derived from the primary tumor cells, to susceptible target cells. The oncogenic potential of ...
Singh Rajesh R Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310‑1495, - - 2014
CXCR5 and/or CXCL13 expression is elevated in certain carcinomas and lymphomas. To determine if these factors are involved in progression of non‑small cell lung cancer (LuCa), we evaluated their expression in patients with various forms of this disease. Lung biopsies from patients with non‑neoplastic cells (n=8), squamous cell carcinoma (SCC; n=24), or adenocarcinoma (AC; ...
Pinevich A A AA Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia, - - 2014
Mesenchymal stromal cells were isolated from the adipose tissue obtained during surgery for breast cancer and cultured under conditions of normal or low oxygen concentrations. In patients that had received a course of radiation and polychemotherapy prior to surgery, the proliferative potential of mesenchymal stromal cells was irreversibly disturbed. In ...
Tan Matthew M Univ of Calif., - - 2014
Autosomal-dominant polycystic kidney disease (ADPKD) is a progressive, proliferative renal disease caused. Kidneys from ADPKD patients are characterized by the presence of cysts which are marked by enhanced proliferation and apoptosis of renal tubular epithelial cells. Current treatment of this disease is supportive as there are few if any clinically ...
Dong Rui R *Department of Pediatric Surgery, Children's Hospital of Fudan University, and Key Laboratory of Neonatal Disease, Ministry of Health, 399 Wan Yuan Road, Shanghai 201102, China †Department of Immunology, Shanghai Medical College, Key Laboratory of Molecular Medicine of Ministry of Education, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China. And Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, 10032, NY, USA 1Rui Dong and Yijie Zheng contributed equally to this manuscript and should be considered as co-first - - 2014
Biliary atresia (BA) is a devastating liver disease in infants. Progressive hepatic fibrosis is often observed in postoperative patients with BA even after a successful Kasai portoenterostomy procedure. MicroRNA-222 (miRNA) has been linked to the activation of stellate cells and the progression of liver fibrosis. In this study, the miR-222 ...
Seeger Florian H FH Centre of Molecular Medicine Molecular Cardiology, Institute for Cardiovascular Regeneration, Goethe University, Haus 25B, 4. Stock, Theodor-Stern-Kai 7, Frankfurt am Main, 60590, - - 2014
Cell therapy of acute myocardial infarction (AMI) with bone marrow-derived mononuclear cells (BMC) resulted in a modest improvement of cardiac function, but clinical trial results were heterogeneous. After isolation, BMC are maintained in medium supplemented with complements such as autologous serum to maintain optimal cell viability until administration. In the ...
Patel Kirtesh K Department of Radiation Oncology and Winship Cancer Institute, Emory University, 1365 Clifton Rd NE, Suite C-3082, Atlanta, GA, 30322, USA, - - 2014
Cisplatin and radiation therapy remain the current standard for treating locally advanced SCCHN. Novel treatment approaches are needed, especially in patients with human papilloma virus (HPV)-negative disease who have worse outcomes despite multimodality therapy. Using our institutional review board approved database, we obtained twenty oropharyngeal squamous cell carcinoma (SCC) tissue ...
Polakowski Nicholas N Brody School of Medicine, Department of Microbiology and Immunology, East Carolina University, Greenville, NC, - - 2014
Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survival and plasticity. These effects occur through autocrine and paracrine signaling events initiated by interactions between secreted BDNF and its high-affinity receptor, TrkB. A BDNF/TrkB autocrine/paracrine signaling loop has additionally been implicated in augmenting survival of cells representing several ...
Zhang Jing J Department of Pharmacy, Shandong Provincial Hospital, Jinan 250021, - - 2014
Tumor metastasis is the leading cause of mortality and morbidity of prostate cancer (PCa) patients. Epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and metastasis. Recent evidence suggested that diabetic patients treated with metformin have lower PCa risk and better prognosis. This study was aimed to investigate the ...
Esteras Noemí N Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, - - 2014
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease among aging individuals, affecting greatly the quality of their life. However, the pathogenesis of Parkinson's disease is still incompletely understood to date. Increasing experimental evidence suggests that cell cycle reentry of postmitotic neurons precedes many instances of neuronal death. Since ...
Glauzy Salomé S Univ Paris Diderot, Sorbonne Paris Cite, Institut Universitaire d'Hematologie, Paris, - - 2014
Using B-cell rearrangement excision circles measurements, we analyzed B-cell reconstitution in a cohort of 243 patients who underwent allogeneic stem cell transplantation. Acute and chronic graft vs. host disease (aGVHD and cGVHD) transiently increased B-cell replication but decreased overall B-cell neogenesis with a clear difference in term of kinetics. Moreover, ...
Pal Sumanta K SK Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer - - 2014
Sarcomatoid metastatic renal cell carcinoma (mRCC) is associated with a poor prognosis and the biology of the disease has been inadequately characterized. RNA sequencing (RNA-seq) was performed on adjacent benign, clear cell, and sarcomatoid components from clinical specimens with sarcomatoid mRCC. M phase and cell cycle pathways were enriched in ...
Sagatun Liv L Department of Gastroenterology and Hepatology, St Olavs Hospital , Trondheim , - - 2014
Abstract Objective. Vagotomy causes inhibition of basal and post-prandial acid secretion in humans, but the knowledge about the trophic effect of the vagal nerves is limited. Vagotomy is known to induce hypergastrinemia and we aimed to study the long-term effects of proximal gastric vagotomy (PGV) on the oxyntic mucosa and ...
Sun Yan-Chang - - 2014
Although the incidence of glioma is relatively low, it is the most malignant tumor of the central nervous system. The prognosis of high-grade glioma patient is very poor due to the difficulties in complete resection and resistance to radio-/chemotherapy. Therefore, it is worth investigating the molecular mechanisms involved in glioma ...
Ren Ping P Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science & - - 2014
Amplification of the MYCN gene in human neuroblastoma predicts poor prognosis and resistance to therapy. We previously showed that MYCN-amplified neuroblastoma cells constantly require large amounts of glutamine to support their unabated growth. However, the identity and regulation of the transporter(s) that capture glutamine in MYCN-amplified neuroblastoma cells and the ...
Guilheiro Joice Marques JM Departments of - - 2014
Abstract Background & objectives. The aim of this study was to evaluate genotoxicity and mutagenicity in peripheral blood and buccal mucosal cells, in mucopolyssacharosis (MPS) I, II or VI patients. Methods. A total of 12 patients with MPS type I, II and VI attended at the Institute of Genetics and ...
Otlu Onder O Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 North Broad Street, 7th Floor, Philadelphia, PA 19140 - - 2014
Poliomavirus JC replicates in glial cells in the brain, and causes the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). PML is usually seen in patients with underlying immunocompromised conditions, notably among AIDS patients and those on chronic immunosuppressive regimens. The late leader sequence of JC virus contains an open reading ...
Varrin-Doyer Michel M Department of Neurology and Program in Immunology (M.V.-D., A.S., C.M.S., U.S.-T., B.A.C.C., S.S.Z.), University of California, San Francisco; Department of Neuropathology and Department of Neurology (M.S.W.), University Medical Center, Georg-August University, Göttingen, Germany; Multiple Sclerosis Research Group (C.C.A.B.), Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia; Department of Immunology (T.F.), University of Texas at San Antonio; and Boehringer Ingelheim (A.J.S.), Ridgefield, - - 2014
Recently, we reported that the 218 amino acid murine full-length myelin oligodendrocyte glycoprotein (MOG) contains novel T-cell epitopes p119-132, p181-195, and p186-200, located within its transmembrane and cytoplasmic domains, and that p119-132 is its immunodominant encephalitogenic T-cell epitope in mice. Here, we investigated whether the corresponding human MOG sequences contain ...
Sureka Binit B Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, - - 2014
Renal cell carcinoma (RCC) is by far the most common soft-tissue mass and accounts for 85% of all malignant masses of the kidney. Histopathological subtype has clinical implications in the form of prognosis and response to various newer and adjuvant treatment strategies. The aim of this study was to evaluate ...
Rajeswari G G Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, - - 2014
Plasma cell leukemia (PCL) is a rare and aggressive variant of plasma cell dyscrasia. They occur de novo (primary) or as a late manifestation of multiple myeloma (secondary). Patients present with anemia, thrombocytopenia, renal failure, organomegaly and extramedullary manifestations. We are presenting this series as it is the second largest ...
Manda Sudhakar S Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, - - 2014
A series of N-substituted tetrahydro-β-carbolines were synthesized and screened for antileishmanial activity through an in vitro assay that involves promastigotes and axenic amastigotes of Leishmania donovani, the causative agent for visceral leishmaniasis. The thiophen-2-yl analogs 9b and 11f and naphthyl analog 11h were found to show significant activity against promastigotes ...
Chen Cao C State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Road 155, Beijing 102206, People's Republic of - - 2014
It has been described that A disintegrin and metalloproteinase (ADAM10) may involve in the physiopathology of prion diseases, but the direct molecular basis still remains unsolved. In this study, we confirmed that ADAM10 was able to cleave recombinant human prion protein in vitro. Using immunoprecipitation tests (IP) and immunofluorescent assays ...
Cohen Philip R PR University of California San - - 2014
Basal cell carcinoma of the axilla, an area that is not usually exposed to the sun, is rare. Individuals with basal cell nevus syndrome, a disorder associated with a mutation in the patch 1 (PTCH1) gene, develop numerous basal cell carcinomas. To describe a woman with basal cell nevus syndrome ...
Wang Jing-Mei JM Department of Pathology, Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing, Jiangsu, China ; Department of Medical Genetics, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School Nanjing, - - 2014
In addition to the typical size, Cryptococcus neoformans can enlarge its size to form titan cells during infection, and its diameter can reach up to 100 μm. Clinical reports about cryptococcal titan cells are rare. Most studies focus on aspects of animal models of infection with titan cells. Herein, we ...
Fan H H The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, - - 2014
B-cell abnormality including excessive activation and lymphopenia is a central feature of systemic lupus erythematosus (SLE). Although activation threshold, auto-reaction and death of B cells can be affected by intrinsical and/or external signaling, the underlying mechanisms are unclear. Herein, we demonstrate that co-activation of Toll-like receptor 7 (TLR7) and B-cell ...
Takahashi Tohru T Department of Hematology, Tenshi Hospital, - - 2014
Plasma cell leukemia (PCL) is a rare variant of multiple myeloma (MM) with a poor prognosis. Nonsecretory myeloma is also a rare form of MM characterized by the absence of detectable M-protein in the serum and urine. This report describes two cases of nonsecretory PCL. The first patient was an ...
Liu Yanying Y Division of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota, United States of - - 2014
Recent advances in trans-differentiation of one type cell to another have made it possible to directly convert Huntington's disease (HD) patient fibroblasts into neurons by modulation of cell-lineage-specific transcription factors or RNA processing. However, this possibility has not been examined. Here, we demonstrate that HD patient-derived fibroblasts can be directly ...
Umesh Soumya - - 2014
Sickle cell anaemia coexisting with gout is a rare clinical association, as is gout and eosinophilia. This report records the second case of chronic tophaceous deposits in Sickle cell anaemia. The patient also had eosinophilia in association with gout. Skeletal fluorosis was an incidental finding in this patient. Treatment with ...
Liu Sulai S Department of Urology, Xiangya Hospital, The Central South University, Changsha, Hunan, - - 2014
Wild-type p53-induced phosphatase (Wip1 or PPM1D) has been reported to be aberrantly expressed in various cancers and correlated with the malignant behavior of cancer cells. However, the function of Wip1 in RCC remains unclear. The present study investigated its abnormal expression and dysfunctions in clear cell renal cell carcinoma (ccRCC) ...
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