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Mizutani Eiji E University of Yamanashi, Kofu Campus, 4-4-37 Takeda, Kofu, Yamanashi, 400-8510, Japan, - - 2015
The successful production of cloned animals by somatic cell nuclear transfer (SCNT) is a promising technology with many potential applications in basic research, medicine, and agriculture. However, the low efficiency and the difficulty of cloning are major obstacles to the widespread use of this technology. Since the first mammal cloned ...
Gkigkitzis Ioannis I Departments of Mathematics and Biomedical Physics, East Carolina University, 124 Austin Building, East Fifth Street, Greenville, NC, 27858-4353, USA, - - 2015
This study contains a discussion on the connection between current mathematical and biological modeling systems in response to the main research need for the development of a new mathematical theory for study of cell survival after medical treatment and cell biological behavior in general. This is a discussion of suggested ...
Parikh Harita H School of Science, NMIMS University , Vile Parle (West), Mumbai, Maharashtra , - - 2014
Abstract Context: Indian mustard [Brassica juncea (L.) Czern. & Coss. (Brassicaceae)] is reported to possess diverse pharmacological properties. However, limited information is available concerning its hepatoprotective activity and mechanism of action. Objective: To study the protective mechanism of mustard seed extract against acetaminophen (APAP) toxicity in a hepatocellular carcinoma (HepG2) ...
Samulitis Betty K BK a University of Arizona Cancer Center , Departments of - - 2014
ABSTRACT Gemcitabine based treatment is currently a standard first line treatment for patients with advanced pancreatic cancer, however overall survival remains poor, and few options are available for patients that fail gemcitabine based therapy. To identify potential molecular targets in gemcitabine refractory pancreatic cancer, we developed a series of gemcitabine ...
Hsia Kan-Tai KT Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, - - 2014
Background. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in DNA repair and redox signaling. The objective of this study was to investigate the relationship between APE1/Ref-1 expression and clinicopathological features, survival and treatment response in oral squamous cell carcinoma (OSCC) patients and cell lines. Methods. APE1/Ref-1 expression ...
Pan Hong-Chao HC Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis; Center for Neuroscience, Shantou University Medical College, Shantou 515041, Guangdong, - - 2014
Gliomas are the most common and malignant primary brain tumours and are associated with a poor prognosis despite the availability of multiple therapeutic options. Quercetin, a traditional Chinese medicinal herb, is an important flavonoid and has anti-cancer activity. Here, we evaluated whether quercetin could inhibit glioma cell viability and migration ...
Mahmoodzadeh Hosseini Hamideh H Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, - - 2015
Texosomes, nano-endosomal vesicles, are candidates for cancer immunotherapy due to their immunostimulating properties. We designed a new structure based on texosome and staphylococcal enterotoxin B (SEB) and assessed its cytotoxic impact on an ovarian cell line. Texosomes were isolated from tumor cells, and SEB was anchored onto by protein transfer ...
Maghsoudi Amirhossein A Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, - - 2014
Parkinson's disease (PD) is the world's second most common dementia, which the drugs available for its treatment have not had effects beyond slowing the disease process. Recently nanotechnology has induced the chance for designing and manufacturing new medicines for neurodegenerative disease. It is demonstrated that by tuning the size of ...
Eom Dae-Woon - - 2014
Epigallocatechin gallate (EGCG) and curcumin are well known to naturally-occurring anticancer agents. The aim of this study was to verify the combined beneficial anticancer effects of curcumin and EGCG on PC3 prostate cancer cells, which are resistant to chemotherapy drugs and apoptosis inducers. EGCG showed weaker inhibitory effect on PC3 ...
Vora Parvez P McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, - - 2014
Neuroblastoma (NB), an embryonal tumour of the sympathetic nervous system, is thought to originate from undifferentiated neural crest cells and is known to exhibit extremely heterogeneous biological and clinical behaviors. Occurring in very young children, the median age at diagnosis is 17 months and it accounts for 10% of all ...
Bielecka Zofia F ZF Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine in Warsaw, Poland ; Postgraduate School of Molecular Medicine, Medical University of Warsaw, - - 2014
Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a consequence of tumor chemo- and radioresistance as well as restrictions in ...
Nakamura Yuka Y Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, - - 2014
Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrupted and cell cycle progression is arrested at ...
Huang Weijuan W Department of Scientific Research, Xi'an Medical College, Xi'an, Shaanxi 710061, P.R. - - 2014
Previous studies have shown that Astragalus and Paeoniae Radix Rubra extract (APE) is capable of protecting against liver fibrosis in rats. The hypothesis of the present study was that APE exerts its anti‑fibrotic effect by mediating the transforming growth factor β (TGF‑β)/Smad signaling pathway. In order to investigate this hypothesis, a ...
Ahmad Md Iftekhar MI Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Prince of Songkla University , Hat Yai, Songkhla , Thailand - - 2014
Abstract Objective: The aim of this study was to conduct in vitro studies of a dry powder formulation of ethambutol dihydrochloride (EDH) to determine if it was an acceptable candidate for further in vivo studies to target alveolar macrophages for the treatment of lung tuberculosis. Nanosized drug particles were prepared ...
Go R-E RE Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of - - 2014
Previous studies suggest that environmental factors, such as high levels of meat consumption, caffeine, cigarette smoking, and endocrine disrupting chemicals (EDC), may enhance a high risk of ovarian cancer. Cytochrome P450 (CYP) 1A1 may play a major role in metabolic activation of procarcinogens to carcinogens. For example, polycyclic aromatic hydrocarbons ...
Kim S-H SH Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of - - 2014
Triclosan (Tri) is one of many endocrine-disrupting chemicals (EDCs) that are scattered with environment agents, such as toothpastes, deodorants, and cleaning supplies. As a phytoestrogen, kaempferol (Kae) is one of bioflavonoids, which has been found in a variety of vegetables including broccoli, tea, and tomatoes. Although Kae may have anti-cancer ...
Lennerz Jochen K JK Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, - - 2014
Comment on: Häberle M-T, Kelsch E, Dorsch K, Möller P, Ritz O. Knock-down of BCL6 / STAT6 sensitizes primary B cell lymphoma cells for treatment with current therapeutic agents. Oncoscience. 2014; 1:283-6.
Berrang Mark E ME U.S. Department of Agriculture, Agricultural Research Service, Russell Research Center, Athens, Georgia 30605, USA. - - 2014
Listeria monocytogenes can colonize a poultry processing plant as a resident in floor drains. Limiting growth and attachment to drain surfaces may help lessen the potential for cross-contamination of product. The objective of this study was to compare a hydrogen peroxide-peroxyacetic acid-based chemical to chitosan-arginine or heat to prevent attachment ...
Zhang Shuang-Shuang SS Department of Cardiovascular Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China, - - 2014
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are the major cause of in-stent restenosis (ISR). Intervention proliferation and migration of VSMCs is an important strategy for antirestenotic therapy. Roscovitine, a second-generation cyclin-dependent kinase inhibitor, can inhibit cell cycle of multiple cell types. We studied the effects of ...
Gajski Goran - - 2014
In the present study, we investigated the possible combined anticancer ability of bee venom (BV) and cisplatin towards two pairs of tumour cell lines: parental cervical carcinoma HeLa cells and their cisplatin-resistant HeLa CK subline,as well as laryngeal carcinoma HEp-2 cells and their cisplatin-resistant CK2 subline. Additionally, we identified several ...
Fogelman Edna E Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, P.O. Box 6, 50250, Bet Dagan, - - 2014
A mixture of 6-benzyladenine (BA) and gibberellins GA4 plus GA7 applied to "Pink Lady" apple at early phenological stages was previously shown to result in an immediate increase in epidermal cell density and associated reduction in calyx-end cracking disorder in the mature fruit, implying a long-term effect of the BA + GA4+7 ...
De Ryck Tine T Laboratory of Experimental Cancer Research, Department Radiation Oncology and Experimental Cancer Research, Ghent University, De Pintelaan 185 1P7, 9000, Ghent, Belgium, - - 2014
The major component in the pathogenesis of oral radiation-induced mucositis is progressive epithelial hypoplasia and eventual ulceration. Irradiation inhibits cell proliferation, while cell loss at the surface continues. We conceived to slow down this desquamation by increasing intercellular adhesion, regulated by the E-cadherin/catenin complex. We investigated if 8-prenylnaringenin (8-PN) or ...
Liu Xiwei X Department of Orthopedics, West China Hospital, Sichuan University, Guoxue Xiang 37#, Chengdu, 610041, - - 2015
Type 2 interleukin-1 receptor (IL1R2) is a member of the IL1 family. It has been reported that IL1R2 is expressed and plays important roles in several cancers. However, its potential role in human osteosarcoma has not been reported. In the present study, a recombinant lentivirus harboring short hairpin RNA against ...
Hirata Rei R Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, Okayama 700-8530, - - 2014
The corpus luteum (CL) forms after ovulation and acts as a temporary endocrine gland that produces progesterone (P4), a hormone that is essential for implantation and maintenance of pregnancy in mammals. In pregnant women, human chorionic gonadotropin (hCG) secreted by the conceptus prevents luteolysis. hCG also increases the survival of ...
Hsu Hsi-Hsien HH Hsi-Hsien Hsu, Division of Colorectal Surgery, Mackay Memorial Hospital, Taipei 251, - - 2014
To investigate the effects of 17β-estradiol via estrogen receptors (ER) or direct administration of ER agonists on human colorectal cancer. LoVo cells were established from the Bioresource Collection and Research Center and cultured in phenol red-free DMEM (Sigma, United States). To investigate the effects of E2 and/or ER selective agonists ...
Yang Soo Jin SJ Department of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Jeonnam 500-757, - - 2014
Adipogenesis is part of the cell differentiation process in which undifferentiated fibroblasts (pre-adipocytes) become mature adipocytes with the accumulation of lipid droplets and subsequent cell morphological changes. Several transcription factors and food components have been suggested to be involved in adipogenesis. The aim of this study was to determine whether ...
Alkotaini Bassam B Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia, - - 2014
The mechanisms of action of AN5-1 against Gram-negative and Gram-positive bacteria were investigated by evaluations of the intracellular content leakage and by microscopic observations of the treated cells. Escherichia coli and Staphylococcus aureus were used for this investigation. Measurements of DNA, RNA, proteins, and β-galactosidase were taken, and the results ...
Kim Mi Joung MJ Institute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of - - 2014
Despite the availability of several therapeutic options, renal cell carcinoma (RCC) is associated with poor clinical outcomes. Therefore, we investigated whether the combination of 5-fluoruracil (5-FU) with the histone deacetylase inhibitor (HDACI) belinostat would exert a synergistic effect on RCC cells in vitro and in vivo. We used SN12C cells ...
Kang Mi Yeon MY Department of Internal Medicine, Seoul National University College of Medicine, Seoul, - - 2014
Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that increases glucose-stimulated insulin secretion in pancreatic β-cells. Since mitochondrial function is crucial to insulin secretion, we hypothesized that GLP-1 may increase mitochondrial biogenesis in pancreatic β-cells. We treated INS-1 rat insulinoma cells with GLP-1 or exendin-4 for 48 hours and ...
Heger Zbynek Z Department of Chemistry and Biochemistry, Mendel University in Brno, CZ-613 00 Brno, Czech - - 2014
The present study suggests and describes the application of a delivery system for antisense oligonucleotides against mRNA encoding estrogen receptor proteins α and β. The delivery system is composed of a cationic liposome envelope containing 17β-estradiol (E2) in its structure. Cationic liposomes protect cargo against the extracellular matrix, and E2 ...
Hinsche Oliver O Department of Gynecology and Obstetrics, Georg‑August University, Göttingen 37075, - - 2014
Metastasis to bone is a frequent problem of advanced breast cancer. Particularly breast cancers, which do not express estrogen receptor α (ERα) and progesterone receptor (PR) and which have no overexpression of human epidermal growth factor receptor 2 (HER2), so‑called triple‑negative breast cancers (TNBCs), are considered as very aggressive and have a poor prognosis. Recently we ...
Donoso-Fierro César C Departamento de Acuicultura, Facultad de Ciencias del Mar, Universidad Católica del Norte , Coquimbo , Chile - - 2014
Abstract Context: Fitzroya cupressoides (Molina) I. M. Johnst. and Austrocedrus chilensis (D. Don) Pic.Serm. & Bizzarri are two Chilean Cupressaceae that are naturally resistant to biodegradation. Secondary metabolites from these species display a variety of biological activities. Objective: To evaluate the antiproliferative activity of two lignans, a diterpene and a ...
Wang Jing J From the Departments of *Oncology, †Infectious Disease and Critical Care Medicine, and ‡Emergency, Capital Medical University, Beijing Friendship Hospital; and §Department of Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, - - 2014
Angiotensin-converting enzyme 2 (ACE2), its product angiotensin-(1-7), and its receptor Mas have been shown to moderate the adverse effects of the ACE-angiotensin II-AT1 axis in many diseases. The aim of this study was to determine whether the ACE2-Ang-(1-7)-Mas axis could have similar effects in a cell culture model of pancreatic ...
Choi Seung-Il SI Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Republic of - - 2014
This study investigates the role of impaired proliferation, altered cell cycle arrest, and defective autophagy flux of corneal fibroblasts in granular corneal dystrophy type 2 (GCD2) pathogenesis. The proliferation rates of homozygous (HO) GCD2 corneal fibroblasts at 72h, 96h, and 120h were significantly lower (1.102±0.027, 1.397±0.039, and 1.527±0.056, respectively) than ...
Wei Zhihong Z Department of Obstetrics and Gynecology, Shenzhen Second People's Hospital, Shenzhen, 518039, Guangdong, - - 2014
Little is known about the role of progranulin (PGRN) in cervical cancer, which is an autocrine growth factor. We used immunohistochemistry, western blot, and ELISA to determine the expression levels of PGRN in cervical cancer and cervical cancer cell lines. Immortalized normal cervical cell line H8 with lower PGRN expression ...
Uehara Takashi T Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, - - 2014
Metformin is a diabetes drug with anticancer properties. Several studies have investigated the effects of metformin combined with chemotherapeutic agents, with controversial results. This study evaluated the efficacy of combined metformin/cisplatin treatment in an endometrial cancer cell line. Ishikawa cells were treated with metformin, cisplatin or both types of treatment. ...
Potenza Mariana M Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. H.N. Torres", INGEBI-CONICET, Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina, - - 2014
This work analyzes the effect of the alkaloid colchicine on the growth of Trypanosoma cruzi epimastigotes, using immunofluorescence microscopy and flow cytometry techniques. We found that colchicine reversibly inhibited cytokinesis but not synthesis or segregation of nuclear and kinetoplastid DNA, in a concentration-dependent manner. We showed that, once colchicine was ...
Saini M - - 2014
We examined the effects of treating buffalo skin fibroblast donor cells with trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, and 5-aza-2?-deoxycytidine (5azadC), a DNA methyltransferase (DNMT) inhibitor, on the cells and embryos produced by hand-made cloning. Treatment of donor cells with TSA or 5azadC resulted in altered expression levels ...
Zhang Yan Fang YF Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou, Zhejiang 310058, China. - - 2014
Arsenic trioxide has been successfully used for the treatment of patients with acute promyelocytic leukemia (APL) worldwide. Recently, it has also been further developed to treat solid tumors in clinical trials. However, the therapeutic effects on malignant tumors appeared to be unsatisfactory, as these cells exhibited resistance towards arsenic. In ...
Unland Rebekka R aDepartment of Pediatric Hematology and Oncology, University Children's Hospital Münster bDepartment of General and Visceral Surgery, University Hospital of Münster, Münster cDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg dSwabian Suabian Children's Cancer Center, Children's Hospital Augsburg, Augsburg, - - 2014
Rhabdoid tumors (RTs) are highly aggressive pediatric malignancies with a rather poor prognosis. New therapeutic approaches and optimization of already established treatment protocols are urgently needed. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) is highly overexpressed in RTs and associated strongly with epigenetic silencing in cancer. EZH2 is ...
Sun Ming M Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning Province, PR - - 2014
It has been shown that chemotherapy has limited antitumor activity against advanced urothelial bladder cancer (UBC). Consequently, there is an urgent need to develop effective therapeutic methods for patients with advanced UBC. In the present study, the inhibitory effects of lentinan alone, gemcitabine alone, or lentinan combined with gemcitabine on ...
Gonzales Silvia S Department of Biomedical Engineering, College of Engineering, University of Miami, P.O. Box 248294, Coral Gables, FL, 33124-0621, - - 2014
We have recently found a high accumulation of extracellular adenosine triphosphate (ATP) in the center of healthy porcine intervertebral discs (IVD). Since ATP is a powerful extracellular signaling molecule, extracellular ATP accumulation might regulate biological activities in the IVD. The objective of this study was therefore to investigate the effects ...
Grygielewicz Paulina P Innovative Drugs R&D Department, Celon Pharma Inc., Mokra 41a, 05-092, Lomianki/Kielpin, Poland, - - 2014
Up to 10 % of primary gastric cancers are characterized by FGFR2 amplification, and fibroblast growth factor receptor (FGFR) inhibitors may represent therapeutic agents for patients with these malignancies. However, long-term benefits of the treatment might be limited owing to the occurrence of drug resistance. To investigate the mechanisms of resistance to selective ...
Yongsanguanchai Nuttida N Chulalongkorn - - 2014
Even though tremendous advances have been made in the treatment of cancers during the past decades, success rate among cancer patients is still dismal largely due to problems associated with chemo/radio-resistance and relapse. Emerging evidence has indicated that cancer stem cells (CSCs) are behind the resistance and recurrence problems, but ...
Jamshidi Mitra M Department of Plant Biology, Faculty of Biological Science, Tarbiat Modares University (TMU), P.O. Box 14115-154, Tehran, - - 2014
Elicitation effect of silver nano particles (AgNPs) and triggering of defence system by production of hydrogen peroxide (H2O2) as a signaling molecule in the regulation of the activity of stress-related enzymes and production of Taxol was evaluated in suspension- cultured hazel cells (Corylus avellana L.). The cells were treated with ...
Kasukabe Takashi T Department of Medical Education and Research, Faculty of Medicine, Shimane University, Izumo 693-8501, - - 2014
Arsenic trioxide (ATO) is an approved treatment for acute promyelocytic leukemia (APL). It has also shown potential for treatment of multiple myeloma and various solid tumors including breast cancer. The requirement of high, toxic concentrations for the induction of apoptosis in non-APL and solid tumor cells is a major limitation ...
Morgan Sherif S - - 2014
Curative treatments for patients with metastatic synovial sarcoma (SS) do not exist, and such patients have a poor prognosis. We explored combinations of molecularly-targeted and cytotoxic agents to identify synergistic treatment combinations in SS cells. Two SS cell lines (HS-SY-II and SYO-I) were treated with single agents or combinations of ...
Maria Durvanei Augusto - - 2014
Malignant melanoma is a less common but highly dangerous form of skin cancer; it starts in the melanocytes cells found in the outer layer of the skin. Jararhagin toxin, a metalloproteinase isolated from Bothrops jararaca snake venom acts upon several biological processes, as inflammation, pain, platelet aggregation, proliferation and apoptosis, ...
Guan Guofeng G Orthopaedic Oncology Institute, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, - - 2014
HIF-1α mediates hypoxia-induced expression of the chemokine receptor CXCR4 and contributes to metastasis in many different cancers. We have previously shown that hypoxia promotes migration of human osteosarcoma cells by activating the HIF-1α/CXCR4 pathway. Here, immunohistochemical analysis showed that unlike control osteochondroma samples, osteosarcoma specimens were characterized by elevated expression ...
Pan Banzhou B Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, - - 2014
Although the combination of etoposide (VP16) and cisplatin (DDP) is widely used as a first-line treatment for advanced-stage small-cell lung cancer (SCLC), chemoresistance limits its clinical use. Abnormalities of autophagy are associated with tumor chemoresistance. The present study found that miR-24-3p, a recently discovered microRNA, is significantly downregulated in VP16-DDP-resistant ...
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