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Results 201 - 250 of 2543
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Lin Ying-Hsi YH School of Pharmacy, National Taiwan University, No. 33, Linsen S. Road, Taipei, 10050, - - 2014
Abnormalities in the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway are commonly observed in human cancers and contribute to chemotherapy resistance. Combination therapy, involving the use of molecular targeted agents and traditional cytotoxic drugs, may represent a promising strategy to lower resistance and enhance cytotoxicity. Here, we demonstrate the efficacy of an ...
Serasanambati Mamatha M a Department of Biochemistry , S. V. University , Sugen Life Sciences Pvt Ltd, #4/86, S.V. Nagar, Perumalla Palli, Tirupati 517505 , Andhra Pradesh , - - 2014
This study was designed to investigate the combination effects of brucine and gemcitabine, each with anticancer properties, in MCF-7 human breast cancer cells in culture. With regard to cell viability, effects of both the drugs and their combinations were inversely proportional to dose and time. For various proportional drug combinations ...
Badisa Ramesh B RB College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, - - 2014
Cocaine is a powerful addictive drug, widely abused in most Western countries. It easily reaches various domains within and outside of the central nervous system (CNS), and triggers varying levels of cellular toxicity. No pharmacological treatment is available to alleviate cocaine-induced toxicity in the cells without side-effects. Here, we discerned the ...
Ammoun Sylwia S Plymouth University, Peninsula Schools of Medicine and Dentistry, The Institute of Translational and Stratified Medicine, The John Bull Building, Tamar Science Park, Research Way, Plymouth PL6 8BU, - - 2014
Deficiency of the tumour suppressor merlin leads to the development of schwannomas, meningiomas and ependymomas occurring spontaneously or as a part of the hereditary disease Neurofibromatosis type 2 (NF2). Merlin loss is also found in a proportion of other cancers like mesothelioma, melanoma, breast cancer and glioblastoma. The tumour suppressor/transcription ...
Guo Juan J Department of Wood Anatomy and Utilization, Research Institute of Wood Industry, Chinese Academy of Forestry, Beijing 100091, - - 2015
The effects of compression combined with steam treatment (CS-treatment), i.e. a hygro-mechanical steam treatment on Spruce wood were studied on a cell-structure level to understand the chemical and physical changes of the secondary cell wall occurring under such conditions. Specially, imaging FT-IR microscopy, nanoindentation and dynamic vapour absorption were used ...
Castro Gisela Natalia GN Oncology Laboratory, IMBECU-CCT, CONICET, National Research Council, Av. Dr. Ruiz Leal s/n, Parque General San Martín, CP 5500, Mendoza, - - 2014
We previously reported the association of HSPA1A and HSPB1 with high-grade astrocytomas, suggesting that these proteins might be involved in disease outcome and response to treatment. With the aim to better understand the resistance/susceptibility processes associated to temozolomide (TMZ) treatment, the current study was performed in three human malignant glioma ...
Matsunaga Toshiyuki - - 2014
Abstract In this study, we show that exposure of human lung cancer A549 cells to cisplatin (cis-diamminedichloroplatinum, CDDP) promotes production of nitric oxide (NO) through generation of reactive oxygen species (ROS) and resultant up-regulation of inducible NO synthase (iNOS). The incubation of the cells with a NO donor diethylenetriamine NONOate ...
Lukin Dana J DJ Oncological Sciences, Icahn School of Medicine at Mount - - 2014
The tumor suppressor p53 (TP53) has a well-studied role in triggering cell cycle checkpoint in response to DNA damage. Previous studies have suggested that functional p53 enhances chemosensitivity. In contrast, data are presented to show that p53 can be required for cell survival following DNA damage due to activation of ...
Proksch Susanne S Centre for Dental Medicine, University Medical Centre Freiburg Department of Operative Dentistry and Periodontology Freiburg, - - 2014
Background: Melatonin was proposed for employment in periodontitis and peri-implantitis therapy due to its bone-supportive effects. This issue is captivating because standard adjuvant antiseptics, namely chlorhexidine (CHX), prove damaging for osteoblasts. Thus, the aim of our study was to investigate if melatonin is suited as auxiliary agent for protecting osteoblasts ...
Wang Shenxu S 1Cardiology Department, Chinese PLA General Hospital, Beijing, - - 2014
ABSTRACT Purpose: To investigate the effect of cisplatin on the growth and metastasis abilities of lung cancer stem cells (CSCs) via molecular imaging. Materials and Methods: The expression changes of lung CSCs cell marker in A549-Luc-C8 human non-small-cell lung cancer (NSCLC) cell line with or without cisplatin treatment were detected ...
Zhang Xu X Brain Hospital, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China; Insititute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, - - 2014
The identification of genes involved in carcinogenesis and tumor progression is of great interest, since these genes might be possible as candidates for new tumor targeted therapy strategies. Our previous study shows that Golgi phosphoprotein 3 (GOLPH3) is involved in glioma cell migration and invasion, the critical characteristics of malignant ...
Brandt Moritz D MD Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, 01307 Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE), Research Site Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Dresden University of Technology, 01307 Dresden, Germany. Electronic address: - - 2014
The generation of new neurons in the dentate gyrus of the adult brain has been demonstrated in many species including humans and is suggested to have functional relevance for learning and memory. The wake promoting drug modafinil has popularly been categorized as a so-called neuroenhancer due to its positive effects ...
Hunakova Luba L Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, 833 91 Bratislava, Slovak - - 2014
Cisplatin resistance is one of the major obstacles in the treatment of ovarian cancer. In an effort to look for new possibilities of how to overcome this difficulty, we studied the mechanisms of the interactions between sulforaphane (SFN) and cisplatin (cisPt) in combined treatment of human ovarian carcinoma A2780 and ...
Firdessa Rebuma R Institute for Molecular Infection Biology, University of Würzburg, Würzburg, - - 2014
Nanoparticles may address challenges by human diseases through improving diagnosis, vaccination and treatment. The uptake mechanism regulates the type of threat a particle poses on the host cells and how a cell responds to it. Hence, understanding the uptake mechanisms and cellular interactions of nanoparticles at the cellular and subcellular ...
Yin Yue - - 2014
Abstract Inhibition of the cell mitotic pathway may provide a novel means for therapeutic intervention in CML. Kinesin spindle protein (KSP), a microtubule-associated motor protein essential for cell cycle progression, is over expressed in bcr-abl+ CML cells. Retrovirus mediated bcr-abl transduction increases KSP expression in cord blood CD34+ cells. SB743921 ...
Bliss-Moreau Meghan M Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, - - 2014
Cutaneous T-Cell Lymphomas (CTCL) represent a group of hematopoietic malignancies that home to the skin and have no known molecular basis for disease pathogenesis. Sézary syndrome (SS) is the leukemic variant of CTCL. Currently, CTCL is incurable, highlighting the need for new therapeutic modalities. We have previously observed that combined ...
Tan Joey Wee-Shan JW Department of Anatomy, National University of Singapore, Singapore, 119260, - - 2014
Silver nanoparticles (AgNPs) are among the most commonly used nanomaterials, but thus far, little is known about ways to mitigate against potential toxic effects of exposure. In this study, we examined the potential effects of AgNPs on mitochondrial function and cellular ATP levels, and whether these could be prevented by ...
Tallawi Marwa M University of Erlangen-Nuremberg, Institute of Biomaterials, Department of Materials Science and Engineering, Enlargen, Germany ; - - 2014
Cardiac tissue engineering constructs are a promising therapeutic treatment for myocardial infarction, which is the leading cause of death worldwide. In order to further advance the development and regeneration of engineered cardiac tissues using biomaterial platforms it is important to have a complete overview of the effects that substrates have ...
Xie Zuoming Z School of Environmental Studies, China University of Geosciences, Wuhan, 430074, People's Republic of - - 2014
Species differences in inorganic arsenic tolerance were investigated by comparing the responses of Bacillus subtilis (B. subtilis) and Bacillus thuringiensis (B. thuringiensis) to elevated concentrations of As(III) and As(V). The cell densities in treatments were always lower during the experiment compared to controls, with the exception of exposure to 1.0 mg ...
Yun Miyong M College of Korean Medicine, Kyung Hee University, Seoul, South - - 2014
Background/Aims: The use of tyrosine kinase inhibitors (TKIs) to target active epidermal growth factor receptor (EGFR)-harbouring mutations has been effective in patients with advanced non-small-cell lung cancer (NSCLC). However, the use of TKIs in NSCLS patients with somatic EGFR mutations, particularly T790M, causes drug resistance. Thus, in the present study, ...
Mo Ning N The Fifth Department of Chemotherapy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, P.R. - - 2014
Radiotherapy has long been considered as the mainstay of treatment for nasopharyngeal carcinoma (NPC). However, locoregional recurrence or distant metastasis may occur in some patients due to the radiation resistance of cancer cells. Autophagy plays a vital role in protecting cells against radiation. However, the mechanism of autophagy in radiation ...
Chen Jian J Department of Orthopaedics, Shanghai First People's Hospital, Nanjing Medical University, Shanghai, - - 2014
Background: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents and is characterized by frequent metastasis and resistance to chemotherapy. Because osteosarcoma cells are not highly susceptible to current chemotherapy drugs, new alternative strategies for the treatment of osteosarcoma are needed. This study was undertaken to ...
Chen Gangyi G Division of Nephrology, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. - - 2014
Tanshinone ⅡA (TⅡA) is widely used for the treatment of a number human diseases, including diabetic nephropathy (DN) (1). The present study was performed to examine the role of the transforming growth factor β (TGFβ)/p65 pathway under TⅡA treatment in a glomerular mesangial cell model of DN. Firstly, it was identified that TⅡA ...
Sakashita Mizuha M Department of Chemistry and Biochemistry, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka 808-0135, - - 2014
Highly efficient drug carriers targeting hepatocyte is needed for treatment for liver diseases such as liver cirrhosis and virus infections. Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively expressed on hepatocyte and hepatoma. In this study, we synthesized ...
Lyons Deirdre C DC *Department of Biology, 4115 French Family Science Center, Duke University, Durham, NC 27708, USA; Whitney Laboratory for Marine Biosciences, University of Florida, St Augustine, FL 32080, USA; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA dclyons1@gmail.com - - 2014
An adult animal's form is shaped by the collective behavior of cells during embryonic development. To understand the forces that drove the divergence of animal body-plans, evolutionary developmental biology has focused largely on studying genetic networks operating during development. However, it is less well understood how these networks modulate characteristics ...
Krasavin Mikhail M Department of Chemistry, St. Petersburg State University, Peterhof 198504, - - 2014
We discovered a new chemical class of antiproliferative agents, 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides. SAR-guided optimization of the two distinct terminal fragments yielded a compound with 120nM potency in an antiproliferative assay. Biological activity profile studies (COMPARE analysis) demonstrated that 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides act as tubulin inhibitors, and this conclusion was confirmed via biochemical assays with ...
Ometto Francesco F Cranfield University, Bedfordshire, - - 2014
Anaerobic digestion (AD) of microalgae is primarily inhibited by the chemical composition of their cell walls containing biopolymers able to resist bacterial degradation. Adoption of pre-treatments such as thermal, thermal hydrolysis, ultrasound and enzymatic hydrolysis have the potential to remove these inhibitory compounds and enhance biogas yields by degrading the ...
Eckerdt Frank F Robert H. Lurie Comprehensive Cancer Center and Division of Hematology- Oncology, Feinberg School of Medicine, Northwestern University, Chicago, - - 2014
The mTOR pathway controls mRNA translation of mitogenic proteins and is a central regulator of metabolism in malignant cells. Development of malignant cell resistance is a limiting factor to the effects of mTOR inhibitors, but the mechanisms accounting for such resistance are not well understood. We provide evidence that mTORC1 ...
Wang Piwen P Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA ; Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, - - 2014
The low bioavailability of most flavonoids limits their application as anti-carcinogenic agents in humans. A novel approach of treatment with a mixture of bioactive compounds that share molecular anti-carcinogenic targets may enhance the effect on these targets at low concentrations of individual compound, thereby overcoming the limitations of reduced bioavailability. ...
Liu Ying Y Department of Animal Science, Aarhus University, DK-8830 Tjele, - - 2014
In somatic cell nuclear transfer (SCNT), donor cell reprogramming is considered as a biologically important and vulnerable event. Various donor cell pre-treatments with Xenopus egg extracts can promote reprogramming. Here we investigated if the reprogramming effect of one treatment with Xenopus egg extract on donor cells was maintained for several ...
Fawzy Ghada Ahmed GA Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia ; Faculty of Pharmacy, Cairo University, Cairo, - - 2014
Previous investigation of the methanol extract of Plicosepalus curviflorus leaves led to the isolation of two new flavane gallates (1, 2), together with other compounds including quercetin (3). The stems of P. curviflorus are used traditionally for the treatment of cancer in Yemen. The aim of this study was to ...
Moorthi A A Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, - - 2014
At nanoscale, bioglass ceramic (nBGC) particles containing calcium oxide (lime), silica and phosphorus pentoxide promote osteoblast proliferation. However, the role of varied amounts of calcium and silica present in nBGC particles on osteoblast proliferation is not yet completely known. Hence, the current work was aimed at synthesizing two different nBGC ...
Vincent Zangiacomi Z Regional Resources Division, Shizuoka Cancer Center Research Institute, Shizuoka, - - 2014
During the past decade, cancer stem-like cells (CSCs) have drawn substantial interest in cancer research since they have been described as major targets to improve treatment of tumors and to prevent recurrence and metastasis. In this paper, we report on the search for CSCs within the Colo205 human adenocarcinoma cell ...
Harada Asako A Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, - - 2014
The phosphorylated form of the histone protein H2AX, called γH2AX, is recognized as a useful biomarker not only for DNA double-strand breaks but also for a wide range of other DNA damage. An increasing number of publications propose γH2AX to be measured when determining genotoxicity, phototoxicity, and the effectiveness of ...
Petralia Ronald S RS Advanced Imaging Core, NIDCD/NIH, Bethesda, MD 20892, United States. Electronic address: - - 2014
Here we review the examples of great longevity and potential immortality in the earliest animal types and contrast and compare these to humans and other higher animals. We start by discussing aging in single-celled organisms such as yeast and ciliates, and the idea of the immortal cell clone. Then we ...
Corominas-Faja Bruna B Metabolism and Cancer Group, Translational Research Laboratory, Catalan Institute of Oncology, Girona, Catalonia Spain. Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia - - 2014
Cancer stem cells (CSC) may take advantage of the Warburg effect-induced siphoning of metabolic intermediates into de novo fatty acid biosynthesis to increase self-renewal growth. We examined the anti-CSC effects of the antifungal polyketide soraphen A, a specific inhibitor of the first committed step of lipid biosynthesis catalyzed by acetyl-CoA ...
Benghuzzi Hamed A HA University of Mississippi Medical Center, - - 2014
Surgically repaired tendons are plagued by complications related to the healing response. Adhesion formation between the tendon and its sheath or surrounding tissues inhibits free gliding and results in a loss of excursion. The random orientation of collagen deposition at the site of repair creates a focal area of weakness, ...
Brown R Keith RK University of Mississippi Medical Center, - - 2014
Acute Lymphoblastic Leukemia remains the most common cancer for children, and if left untreated is rapidly fatal. The gold standard for treatment of ALL in children is with a class of drugs known as the antracyclines. Long term outcomes following treatment of leukemia with antracylines can result in cardiac abnormalities ...
De Luna-Bertos Elvira E Department of Nursing, School of Health Sciences, University of Granada, Granada, - - 2014
Some nonsteroidal anti-inflammatory drugs (NSAIDs) have adverse effects on bone tissue. The objective of this study was to determine the effect of different doses of dexketoprofen, ketorolac, and metamizole on growth of the osteoblast MG63 cell line. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide spectrophotometry results showed that MG63 cell growth was significantly inhibited after ...
Febriansah Rifki R Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta, Indonesia ; Pharmacy study programme, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta, Yogyakarta, - - 2014
To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin. The cytotoxic properties, 50% inhibition concentration (IC50) and its combination with doxorubicin in MCF-7 cell lines resistant to doxorubicin (MCF-7/Dox) cells were determined using ...
Ansil P N PN Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, P.D. Hills P.O., Kottayam, Kerala 686560, - - 2014
Colorectal cancer is one of the leading causes of cancer death worldwide and is the third most common form of malignancy in both men and women. Several possible colon cancer chemopreventive agents are found in edible plants. Amorphophallus campanulatus (Roxb.) Blume (family: Araceae) is a tuber crop, largely cultivated throughout ...
Cao Lihuan - - 2014
The molecular history of animal evolution from single-celled ancestors remains a major question in biology, and little is known regarding the evolution of cell cycle regulation during animal emergence. In this study, we conducted a comprehensive evolutionary analysis of CDK and cyclin proteins in metazoans and their unicellular relatives. Our ...
Liu Jia J Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China E-mail : - - 2014
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected ...
Gong Joyce J Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney , Sydney, NSW , Australia ; Sydney Medical School and Bosch Institute, The University of Sydney , Sydney, NSW , - - 2014
The successful treatment of cancer is hampered by drug resistance and metastasis. While these two obstacles were once considered separately, recent evidence associates resistance with an enhanced metastatic capacity. However, the underlying mechanisms remain undefined. We previously described the intercellular transfer of drug resistance via submicron vesicles called microparticles (MPs). ...
Fong Yao Y Department of Thoracic Surgery, Chi-Mei Medical Center, Tainan 710, - - 2014
Sirtuins, NAD(+)-dependent deacetylases, could target both histones and nonhistone proteins in mammalian cells. Sirt1 is the major sirtuin and has been shown to involve various cellular processes, including antiapoptosis, cellular senescence. Sirt1 was reported to be overexpressed in many cancers, including lung cancer. Sirtinol, a specific inhibitor of Sirt1, has ...
Landmann H H Göttingen Centre of Molecular Biosciences (GZMB), Institute of Molecular Oncology, Faculty of Medicine, University of Göttingen, 37077 Göttingen, - - 2014
HSP90 inhibition represents a promising route to cancer therapy, taking advantage of cancer cell-inherent proteotoxic stress. The HSP90-inhibitor ganetespib showed benefit in advanced clinical trials. This raises the need to identify the molecular determinants of treatment response. We tested the efficacy of ganetespib on a series of colorectal cancer (CRC)-derived ...
Ke Xiao-Xue XX State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, - - 2014
Histone methylation plays an important role in gene transcription and chromatin organization and is linked to the silencing of a number of critical tumor suppressor genes in tumorigenesis. G9a is a histone methyltransferase (HMTase) for histone H3 lysine 9. In this study, we investigated the role of G9a in neuroblastoma ...
Xu Wei W State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China E-mail : - - 2014
In this study, we aimed to evaluate the growth inhibitory effect of the combination of ethaselen (BBSKE) and low fixed dose of selenite against A549 human non-small cell lung cancer cells in vitro. Growth inhibitory effects against A549 cells were determined by SRB assay. Combination index (CI) values were calculated ...
Huang Ching-Cheng CC Department of Biomedical Engineering, Ming-Chuan University, 5 De Ming Rd., Gui Shan District, Taoyuan, 333, Taiwan Metal Industries Research & Development Centre, 6F, No. 162-24, Sec. 3, Hsin-Yi Rd., Taipei 10658, - - 2014
The small intestinal submucosa (SIS) is an acellular collagen-based matrix, primarily composed of fibrillar collagens (types I, II, and V). They enhance healing due to a minimal immune response. A good degradation rate is the degradation of materials equal to the rate of remodeling in the host. The SIS should ...
Loriot Y Y 1] Gustave Roussy, Cancer Campus, Grand Paris, 114 rue Edouard Vaillant, Villejuif 94805, France [2] INSERM 1030 "radiosensitivity and human carcinogenesis", 114 rue Edouard Vaillant, Villejuif 94805, France [3] Faculty of Medicine, University of Paris-Sud, DHU TORINO, LABEX LERMIT, SIRIC Socrates, Le Kremlin-Bicêtre, - - 2014
Radiotherapy has a critical role in the treatment of small-cell lung cancer (SCLC). The effectiveness of radiation in SCLC remains limited as resistance results from defects in apoptosis. In the current study, we investigated whether using the Bcl-2/Bcl-XL inhibitor S44563 can enhance radiosensitivity of SCLC cells in vitro and in ...
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