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Dhanushkodi Anandh A School of Regenerative Medicine, Manipal University, Yelahanka, Bangalore, - - 2014
Hippocampal neurodegeneration is one of the hallmarks in neurological and neurodegenerative diseases such as temporal lobe epilepsy and Alzheimer disease. Human embryonic kidney (HEK) cells are a mixed population of cells, including neurons, and their conditioned medium is enriched with erythropoietin (EPO). Because EPO is a known neuroprotectant, we hypothesized ...
Lam Sze-Kwan SK Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR, P.R. - - 2014
Malignant pleural mesothelioma is a global health issue. Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma and colorectal cancer, and induce apoptosis in acute promyelocytic leukemia. With TYMS as a putative therapeutic target, the effect of ATO in mesothelioma was therefore studied. A panel ...
Schmid D D Blood Group Serology and Transfusion Medicine, Salzburg University Hospital (SALK), Salzburg, Austria; Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, - - 2014
Extracorporeal photochemotherapy (ECP) is an established therapy in various diseases, such as cutaneous T-cell lymphoma and graft-versus-host disease. This study was performed to investigate the practicability of a flow cytometric T-cell evaluation after ECP as a tool to validate the quality of ECP procedures and to enable the comparability of ...
Khan Muhammad M Department of Pathology, The Second Hospital of Jilin University, Changchun 130041, P.R. - - 2014
The tumor necrosis factor-α-related apoptosis‑inducing ligand (TRAIL) has been shown to selectively induce death in cancer cells without affecting healthy cells. Most glioma cells are resistant to TRAIL-induced apoptosis. Resistance to TRAIL limits its potential use as a drug for therapy of glioma. The present study was conducted to identify ...
Hou Jian-Wen JW Department of Geriatrics, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China; Department of Electronic and Information Engineering Center, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China; Department of Clinical Science Experiment Center, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, - - 2014
In the present study, water-soluble chitosan (WSC) was prepared by hydrolysis of chitosan with commercial α-amylase, and the effect of WSC on osteoblast function, i.e. alkaline phosphatase activity (ALP), cell viability, mineralization, and reactive oxygen species (ROS) in osteoblastic MC3T3-E1 cells was investigated. Osteoblastic MC3T3-E1 cells were cultured in various ...
Tarapacki Christine C Department of Physics, Ryerson University, Toronto, - - 2014
Gold nanorod (AuNR) laser therapy (LT) is a non-invasive method of increasing the temperature of a target tissue using near infrared light. In this study, the effects of ultrasound and microbubbles (USMB) with AuNR and LT were investigated on cell viability. MDA-MB-231 cells in suspension were treated with three different ...
Gonzalez Laetitia L Laboratory of Cell Genetics, Vrije Universiteit Brussel , Brussels , Belgium - - 2014
Abstract Amorphous silica nanoparticles (SiO2-NPs) have been studied for their toxic and genotoxic potential. Although contradictory data have been reported and the possible modes of action are not fully elucidated, aneugenic events have been reported, indicating the microtubule (MT) network as a potential target. To investigate this, we examined the ...
Li Hui H Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230032, Anhui, - - 2014
Skin cancer is the most common malignancy with increasing incidence rates worldwide. The advanced form of skin cancer, melanoma, is resistant to conventional treatment methods, which puts a burden on researchers to identify alternative effective therapeutic approach. Herein, the current study was designed to identify the effects of si-RNA mediated ...
Li W-J WJ Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, - - 2014
Periventricular leukomalacia (PVL) is one of the foremost neurological conditions leading to long-term abnormalities in premature infants. Since it is difficult to prevent initiation of this damage in utero, promoting the innate regenerative potential of the brain after birth may provide a more feasible, prospective therapy for PVL. Treatment with ...
Mousai M M Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center,Royan Institute for - - 2014
Summary Adult canine fibroblasts stably transfected with either cytomegalovirus (CMV) or POU5F1 promoter-driven enhanced green fluorescent protein (EGFP) were used to investigate if pre-treatment of these donor cells with two epigenetic drugs [trichostatin A (TSA), or S-adenosylhomocysteine (SAH)] can improve the efficiency of interspecies somatic cell nuclear transfer (iSCNT). Fluorescence-activated ...
Zhang Bo B Department of Echocardiography, Tongji University Affiliated Shanghai East Hospital, Shanghai 200120, P.R. - - 2014
The present study aimed to investigate whether low frequency low energy ultrasound combined with microbubbles induces apoptotic cell death of A7r5 rat aortic vascular smooth muscle cells, and to identify the possible mechanisms underlying this effect. Ultrasonic waves (45 kHz with 0.3 Wcm2 of intensity for 0, 10, 20 and 30 sec) were ...
Wei Yan Y Department of Environmental Hygiene, School of Public Health, Guiyang Medical University, 9 Beijing Road, Yunyan District, 550004, Guiyang, People's Republic of - - 2014
Chronic excessive fluoride intake may cause fluorosis, which chiefly manifests as bone damage (or skeletal fluorosis). However, the molecular mechanism of skeletal fluorosis has not been clarified up to the present. The objective of this study was to analyze the effects of fluoride treatment on two of bone morphogenetic protein ...
Alexy Tamas T Emory - - 2014
MicroRNAs (miRNAs) encapsulated within microparticles (MPs) are likely to have a role in cell-to-cell signaling in a variety of diseases, including atherosclerosis. However, little is known about the mechanisms by which different cell types release and transfer miRNAs. Here, we examined TNF-α-induced release of MP-encapsulated miR-126, miR-21, and miR-155 from ...
Yuan Tein-Ming TM Institute of Biomedical Sciences, National Chung Hsing University, Taichung 40227, Taiwan, - - 2014
Upregulation of the metastasis-promoting S100A4 protein has been linked to tumor migration and invasion, and clinical studies have demonstrated that significant expression of S100A4 in primary tumors is indicative of poor prognosis. However, the involvement of S100A4 in the drug responsiveness of gastric cancer remains unclear. In the present study, ...
Hanmod Santosh S SS Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, - - 2014
Despite advances in treatment regimens, patients with high-risk neuroblastoma have long-term survival rates of < 40%. Wee1 inhibition in combination with CHK1 inhibition has shown promising results in neuroblastoma cells. In addition, it has been demonstrated that panobinostat can downregulate CHK1. Therefore, combination of panobinostat and MK-1775 may result in synergistic ...
Lee Dhong Hyun DH Division of Hematology and Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, - - 2014
Bromodomain and extra terminal domain (BET) proteins are important epigenetic regulators facilitating the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a BET protein inhibitor, has antiproliferative activity against many cancers, mainly through inhibition of c-MYC and upregulation of p21. In this research, we investigated the use ...
Shebaby Wassim N - - 2014
Daucus carota L.ssp.carota (wild carrot), an herb used in folk medicine worldwide, was recently demonstrated to exhibit anticancer activity. In this study we examined the anticancer effect of Daucus carota oil extract (DCOE) fractions on the human breast adenocarcinoma cell lines MDA-MB-231 and MCF-7 and clarified the mechanism of action.Methods ...
Varol Umut U Medical Oncology Clinic, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey, - - 2014
Our aim was to investigate the possible synergistic/additive cytotoxic and apoptotic effects of combination of docetaxel and zoledronic acid (ZA), in PC-3 hormone-refractory prostate cancer cells (HRPC), as well as their docetaxel-resistant sublines. We established a docetaxel-resistant cell line (PC-3R) from PC-3 prostate cancer cells, by intermittent exposure to increasing ...
Guo Lei - - 2014
Phosphorylation of cellular components catalyzed by kinases plays important roles in cell signaling and proliferation. Quantitative assessment of perturbation in global kinome can provide crucial knowledge for elucidating the mechanisms underlying the cytotoxic effects of environmental toxicants. Here we utilized ATP affinity probe coupled with stable isotope labeling by amino ...
Ganguli Arnab A Department of Biotechnology and Dr. B.C. Guha Centre for Genetic Engineering andBiotechnology, University of Calcutta, 35 Ballygunge Circular Road Kolkata, WB 700019, - - 2014
Artemisinin (ART) is a well-known anti-malarial drug, and recently it is shown prospective to selectively kill cancer cells. But low potency makes it inappropriate for use as an anticancer drug. In this study, we modulated the ART-induced autophagy to increase Potency of ART as an anticancer agent. ART reduced the ...
Feng Tao T Department of Oncology, Affiliated People's 6th Hospital, Shanghai Jiaotong University, Shanghai 200233, P.R. - - 2014
Osteosarcoma is the most common type of malignant bone tumor in children and adolescents. Numerous patients are unable to be cured due to the development of resistance of the osteosarcoma cells to chemotherapeutic drugs. Therefore, reversion of drug resistance is urgently required for the treatment of osteosarcoma. Arsenic trioxide (As2O3) ...
Pica A A Department of Biology, University of Naples, Federico II, via Mezzocannone 8, 80134, Naples, - - 2014
Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that defends against oxidative damage due to reactive oxygen species (ROS). A new isoform of MnSOD with cytotoxic activity was recently discovered in liposarcoma cells. Here, we tested the effectiveness of a recombinant form of this isoform (rMnSOD) on leukemic T cells, ...
Maso Victor V Internal Medicine, Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, Campinas, Sao Paulo, - - 2014
This study proposes to investigate quercetin antitumor efficacy in vitro and in vivo, using P39 cell line as a model. The experimental design comprised leukemic cells or xenografts of P39 cells, treated in vitro or in vivo, respectively, with quercetin; apoptosis, cell cycle and autophagy activation were then evaluated. Quercetin ...
Hedbrant Alexander A Department of Health Sciences, Karlstad University, Karlstad, - - 2014
Resistance of tumor cells to chemotherapy, such as 5‑fluorouracil (5‑FU), is an obstacle for successful treatment of cancer. As a follow‑up of a previous study we have investigated the effect of conditioned media (CM) from macrophages of M1 or M2 phenotypes on 5‑FU cytotoxicity on the colon cancer cell lines HT‑29 and ...
Chai Kit Man KM Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan City, 70101, - - 2014
We previously found that BRCA1-BRCA2-containing complex subunit 3 (BRCC3) was highly expressed in tumorigenic rat glioma cells. However, the functional role of BRCC3 in human glioma cells remains to be characterized. This study indicated that the upregulation of BRCC3 expression was induced in two human malignant glioblastoma U251 and A172 ...
- - 2014
Background The success rate in previous attempts at transforming human mesenchymal stem cells (HUMSCs) isolated from Wharton?s jelly of the umbilical cord to dopaminergic cells was a mere 12.7 %. The present study was therefore initiated to establish a more effective procedure for better yield of dopaminergic cells in such ...
Samokhvalov Victor V Faculty of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, University of Alberta, Edmonton, AB, - - 2014
Docosahexaenoic acid (22:6n3, DHA) is an n-3 polyunsaturated fatty acid (PUFA) known to affect numerous biological functions. While DHA possesses many properties that impact cell survival such as suppressing cell growth and inducing apoptosis, the exact molecular and cellular mechanism(s) remain unknown. Peroxisome proliferator-activated receptors (PPARs) are a family of ...
Chang Yu-Jia YJ Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, - - 2014
Glucose-regulated protein 78 (GRP78) is the key regulator of endoplasmic reticular (ER) function. Expression of GRP78 was correlated with malignancy in different cancers. However, the role of GRP78 in the cytotoxic effect of curcumin on colon cancer cells is still unclear. A silencing RNA (siRNA) technique was used to knock ...
Mishra Rachana R Department of Biotechnology, Guru Nanak Dev University, Amritsar, 143005, Punjab, - - 2014
Children diagnosed with neuroblastomas often suffer from severe side as well as late effects of conventional treatments like chemotherapy and radiotherapy. Recent advances in understanding of molecular pathways involved in cellular differentiation and apoptosis have helped in the development of new therapeutic approach based on differentiation-based therapy of malignant tumours. ...
Havelek Radim R Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, Pardubice 532 10, Czech Republic. Electronic address: - - 2014
Present-day oncology sees at least two-thirds of cancer patients receiving radiation therapy as a part of their anticancer treatment. The objectives of the current study were to investigate the effects of the small molecule inhibitors of Wee1 kinase II (681641) and Rad51 (RI-1) on cell cycle progression, DNA double-strand breaks ...
Duan Yuqing Y School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, - - 2014
The autophagy of human hepatoma G2 (HepG2) cells induced by procyanidins from chestnut (Castanea mollissima Bl.) shell (CSPCs) was investigated, and the inherent relationship between autophagic levels and reactive oxygen species (ROS) generation was studied. The results showed that CSPCs induced HepG2 cell death in a time- and concentration-dependent manner, ...
Wang Chao C Department of Biochemistry and Molecular Biology, College of Life Sciences, Bioactive Materials Key Lab of Ministry of Education, Nankai University, Tianjin 300071, - - 2014
Benign prostatic hyperplasia (BPH) is one of the major diseases of the urinary system in elderly men. Tanshinone IIA (Tan IIA) is the active ingredient extracted from the traditional Chinese medicine Salvia, and it has effects of anti-oxidation, anti-inflammation, vascular smooth muscle relaxation and tumour growth inhibition. The present study ...
Salaam Amanee D AD Department of Biomedical Engineering, University of Alabama at Birmingham (UAB), 1530 3rd Avenue South, Birmingham, AL 35294, - - 2014
Enhancing therapeutic efficacy is essential for successful treatment of chemoresistant cancers such as metastatic hormone-refractory prostate cancer (HRPC). To improve the efficacy of doxorubicin (DOX) for treating chemoresistant disease, the feasibility of using nanodiamond (ND) particles was investigated. Utilizing the pH responsive properties of ND, a novel protocol for complexing ...
Saloura Vassiliki V Section of Hematology and Oncology, University of - - 2014
Squamous cell carcinoma of the head and neck (SCCHN) is a relatively common malignancy with suboptimal long-term prognosis, thus new treatment strategies are urgently needed. Over the last decade, histone methyltransferases (HMTs) have been recognized as promising targets for cancer therapy, but their mechanism of action in most solid tumors, ...
Fu Martin M MM Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, - - 2014
Background: It has been proposed that cyclosporine (CsA) may induce epithelial-to-mesenchymal transition (EMT) in gingiva. The aims of the present study were to confirm the notion that EMT occurs in human gingival epithelial (hGE) cells after CsA treatment and to investigate the role of TGF-ß1 on this CsA-induced EMT. Methods: ...
Areta José L JL Exercise and Nutrition Research Group, School of Medical Sciences, RMIT University, Melbourne, Victoria, - - 2014
Leucine is a key amino acid for initiating translation in muscle cells, but the dose-dependent effects of leucine on intracellular signaling are poorly characterized. This study examined the effect that increasing doses of leucine would have on changes in mechanistic target of rapamycin (mTOR)-mediated signaling, rates of protein synthesis, and ...
Fan Xiang-Kui XK Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250012, P.R. China ; Department of Tumour Surgery, Taian Central Hospital, Taian, Shandong 271000, P.R. - - 2014
Previous studies have demonstrated that the growth of tumor cells may be inhibited by antisense oligonucleotides (ASODNs) targeted against human telomerase (hTR) or human telomerase reverse transcriptase (hTERT), resulting in antitumor activity in a wide variety of tumors. However, few studies have investigated the effect of hTERT gene-targeted ASODNs on ...
Wang Lei L International Medical Center, The First Central Hospital of Tianjin, Tianjin 300192, P.R. - - 2014
Leukemia is a leading cause of cancer-related mortality in children worldwide, and multidrug-resistance (MDR) is a main reason for tumor chemotherapy failure. The present study investigated the effects of ADR following incubation with cytokine-induced killer (CIK) cells on reversing MDR in K562/ADR cells. Mononuclear cells were isolated from the peripheral ...
Treon Steven P SP Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: - - 2014
Waldenström macroglobulinemia (WM) is an IgM-secreting B-cell lymphoproliferative disorder, with strong familial predisposition. MYD88 L265P and CXCR4 WHIM mutations are common in WM and support the growth and survival of WM cells. Clinical manifestations of disease are related to both tumor cell infiltration and paraprotein production. Current treatment includes monoclonal ...
Heiduschka Gregor G Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna , Vienna , - - 2014
Abstract Conclusion: Resveratrol shows a growth inhibitory effect in head and neck squamous cell carcinoma (HNSCC) cell lines and acts synergistically in combination with etoposide in three cell lines via the induction of apoptotic and necrotic cell death. In patients with recurrent/distant HNSCC, one of the limited treatment options is ...
Frederick John W JW Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, - - 2014
Background: Advanced cutaneous squamous cell carcinoma (cSCC) is an uncommon and aggressive malignancy. As a result, there is limited understanding of its biology and pathogenesis. CD147 and EGFR have been identified as oncologically important targets, but their relationship remains undefined in cSCC Methods: Multiple cSCC cell lines (Colo-16, SRB-1, and ...
Ghanadan Alireza A Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran. - - 2014
Indeterminate cell histiocytosis is a very rare disorder of histiocytes proliferation. It has both Langerhans and non-Langerhans cell histiocytosis immunophenotypic features. We described a 45-year-old man with a 2 years history of multiple yellow-brown papules and a few red nodules on his trunk and extremities. No internal involvement was detected ...
Hazra Sudipta S Department of Pharmaceutical Technology, Jadavpur University, Kolkata, - - 2014
Anticancer activity of diospyrin and its derivatives (1-5) was evaluated against thirteen human cell lines. Compared to diospyrin (1), the acetylamine derivative (4) exhibited increase in cytotoxicity, particularly in HT-29 colon cancer cells, showing GI50 values of 33.90 and 1.96 μM, respectively. Also, enhanced toxicity was observed when cells, pre-treated with ...
Alta Elizabeth Carmen Pastrana EC Department of Chemistry, University of São Paulo, São Paulo, - - 2014
Desferrioxamine (DFO) is a potent iron chelator used in the treatment of iron overload (IO) disorders. However, due to its low cell permeability and fast clearance, DFO administration is usually prolonged and of limited use for the treatment of IO in tissues such as the brain. Caffeine is a safe, ...
Maeda Fernando Yukio FY Departamento de Microbiologia, Imunologia e - - 2014
Trypanosoma cruzi, the agent of Chagas disease, binds to diverse extracellular matrix proteins. Such an ability prevails in the parasite forms that circulate in the bloodstream, and contributes for host cell invasion. Whether this also applies to the insect stage metacyclic trypomastigotes, the developmental forms that initiate infection in the ...
Zhao Jun-Gang JG Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning Province, China, - - 2014
5-Fu is a pyrimidine analog which is wildly used in the treatment of cancers. The development of strategies that increase its anticancer activity has been studied over the past 20 years. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU. In this study, we investigate ...
Gao Hui H Department of pharmacology, Medical College, Qingdao University, Qingdao, 266021, Shandong, - - 2014
The aim of the study was to evaluate the effect of the hispidulin, a naturally occurring flavonoid, in combination with a new multi-targeted oral medication, sunitinib on renal cell carcinoma (RCC) cell proliferation in vitro and on tumor growth in vivo. After treatment with hispidulin or sunitinib, either alone or ...
Ding Ning N Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, - - 2014
Although the microtubule-stabilizing agent paclitaxel has been widely used for treatment of several cancer types, particularly for the malignancies of epithelia origin, it only shows limited efficacy on hematological malignancies. Emerging roles of O-GlcNAcylation modification of proteins in various cancer types have implicated the key enzymes catalyzing this reversible modification ...
Wang Kai K State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology (DUT), 2 Linggong Rd., 116024, Dalian, P. R. China. - - 2014
As an inorganic photoabsorber, selenium was used in a mesoscopic solar cell with a hybrid organic-inorganic structure of TiO2/Se/P3HT/PEDOT:PSS/Ag, in which the Se layer was prepared by vacuum thermal deposition and post thermal treatment. The microstructure, photoelectrical properties, as well as the rationality in structural design of the solar cell ...
Masuelli Laura L Department of Experimental Medicine, University of Rome "Sapienza", Rome, - - 2014
The survival rate of head and neck squamous cell carcinomas (HNSCC) patients has not considerably changed over the last two decades. Polyphenols inhibit the growth of cancer cells. We determined whether the combination of Resveratrol (RES) and Curcumin (CUR) enhanced their in vitro and in vivo antitumor activities on HNSCC ...
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