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Results 251 - 300 of 1309
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Whitman Mary C - - 2007
In mammals, olfactory bulb (OB) interneurons, granule cells and periglomerular (PG) cells, are generated throughout adulthood. PG cells comprise a heterogeneous population in both morphology and molecular phenotypes. It is unknown whether adult genesis of PG cells occurs among all subtypes or is limited to a subpopulation. We show that ...
Pedroso Cátia M - - 2007
Marine and freshwater stingrays are characterized by the presence of one to three mineralized serrated stingers on the tail, which are covered by epidermal cells secreting venom. When these animals are dorsally touched, the stinger can be introduced into the aggressor by a whip reflex mechanism of the tail, causing ...
Sholl Lynette M - - 2007
Pulmonary Langerhans cell histiocytosis (LCH) is an idiopathic condition affecting predominantly adult smokers. Histologically, LCH is characterized by a nodular, interstitial proliferation of Langerhans cells around the distal airways with associated eosinophils, lymphocytes, and macrophages. Associated findings, such as fibrosis, emphysematous change, and bronchiolitis can be reminiscent of other interstitial ...
Matthews Benjamin J - - 2007
Dendrites distinguish between sister branches and those of other cells. Self-recognition can often lead to repulsion, a process termed "self-avoidance." Here we demonstrate that dendrite self-avoidance in Drosophila da sensory neurons requires cell-recognition molecules encoded by the Dscam locus. By alternative splicing, Dscam encodes a vast number of cell-surface proteins ...
Ekici Y - - 2007
The aim of this study was to investigate the effects of rapamycin (RAPA) on the healing of bladder and abdominal wound closures. Fourteen male Sprague Dawley rats were randomized to receive either RAPA (3 mg/d) or placebo. A midline laparotomy was performed. The bladder was cut and closed with 4-0 ...
Ferran Marta - - 2007
Indeterminate cell histiocytosis is an exceptional and controversial entity with variable clinical, histopathologic or immunohistochemical findings, sharing morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytoses. Neoplastic cells express S-100 and CD1a antigens, but lack Birbeck granules. It has been reported in both adults and children, as solitary ...
Promwikorn Waraporn - - 2007
We investigated changes in the histology and protein expression in the epidermis and sub-epidermis of the black tiger shrimp (Penaeus monondon) during the molting cycle. The epidermis consists of a cell layer located beneath the cuticle, while the sub-epidermis is mainly composed of sub-epidermal cells and tegumental glands. During the ...
Shepherd Gordon M - - 2007
The granule cell of the olfactory bulb was first described by Golgi in 1875 and Cajal and his contemporaries in the 1890s as an enigmatic cell without an axon, whose status as a nerve cell was questionable. Insight into its functions began in the 1960s with evidence that it acted ...
da Silveira A B M - - 2007
The mechanisms involved in the pathogenesis of chagasic megacolon are not completely characterized. Although autoimmunity may play a role in the pathogenesis of Chagas' disease, recent studies suggest a positive association of tissue parasitism, inflammation, and severity of lesions. The aim of this study was to evaluate the role of ...
Blank Fabian - - 2007
Fine particles (0.1-2.5 microm in diameter) may cause increased pulmonary morbidity and mortality. We demonstrate with a cell culture model of the human epithelial airway wall that dendritic cells extend processes between epithelial cells through the tight junctions to collect particles in the "luminal space" and to transport them through ...
Anderson I E - - 2007
Malignant catarrhal fever (MCF) is an often-fatal lymphoproliferative disease of a variety of ungulates that occurs worldwide. It is caused by either of the highly related but distinct gammaherpesviruses alcelaphine herpesvirus-1 (AlHV-1, wildebeest reservoir) or ovine herpesvirus-2 (OvHV-2, sheep reservoir). MCF in rabbits is an excellent model as it closely ...
Jameson Julie - - 2007
There is a resident population of T cells found in murine skin that expresses an invariant Vgamma3Vdelta1 T-cell receptor (TCR), and these cells are significantly different from lymphoid gammadelta T cells and alphabeta T cells in terms of ontogeny, tissue tropism, and antigen receptor diversity. These dendritic epidermal T cells ...
Tsuruta Daisuke - - 2007
Pemphigus is an autoimmune blistering disease which is characterized histologically by intraepidermal blisters due to separation of epidermal cell-cell contacts, and immunopathologically by circulating IgG type autoantibodies directed against the desmosomes, which is the cell-cell attachment device in the epidermis. This review briefly summarizes current concepts of conventional diagnosis and ...
Sigmundsdottir Hekla - - 2007
During adaptive immune responses, dendritic cells activate T cells and endow them with specific homing properties. Mechanisms that 'imprint' specific tropisms, however, are not well defined. We show here that 1,25(OH)(2)D(3), the active form of vitamin D3, signaled T cells to express CC chemokine receptor 10, which enabled them to ...
Van Rhijn Ildiko - - 2007
In all species studied so far, gammadelta T cells are abundantly present in epithelia. The functions of these cells are largely unknown. Using a lymph duct cannulation method, which is only possible in large animals such as cattle, we show that large numbers of gammadelta T cells, but not alphabeta ...
Quintin Aurelie - - 2007
Current restrictions for human cell-based therapies have been related to technological limitations with regards to cellular proliferation capacity, maintenance of differentiated phenotype for primary human cell culture, and transmission of communicable diseases. We have seen that cultured primary fetal cells from one organ donation could possibly meet the exigent and ...
Ashman Robert F - - 2007
Synthetic oligodeoxyribonucleotides (ODN) bearing certain sequence characteristics mimic bacterial DNA by activating B cells and dendritic cells through Toll-like receptor (TLR) 9, an event that potentiates both humoral and cell-mediated immunity. ODN sharing some of the sequence characteristics of strong stimulatory (ST-) ODN, but substituting GGG for CGTT, competitively inhibit ...
Campaner Adriana B - - 2007
OBJECTIVE: To compare the number of Langerhans cells in areas of CIN 3 and in areas without histopathological alteration adjacent to CIN 3 with those found in histologically normal control cases. MATERIAL AND METHODS: Specimens were obtained from 46 normal cervixes from women undergoing hysterectomies due to uterine leiomyomata and ...
Hsiao Chung-Der - - 2007
Epidermal ionocytes play essential roles in the transepithelial transportation of ions, water, and acid-base balance in fish embryos before their branchial counterparts are fully functional. However, the mechanism controlling epidermal ionocyte specification and differentiation remains unknown. In zebrafish, we demonstrated that Delta-Notch-mediated lateral inhibition plays a vital role in singling ...
Diebold Yolanda - - 2007
This study evaluated in vitro and in vivo a colloidal nanosystem with the potential to deliver drugs to the ocular surface. This nanosystem, liposome-chitosan nanoparticle complexes (LCS-NP), was created as a complex between liposomes and chitosan nanoparticles (CS-NP). The conjunctival epithelial cell line IOBA-NHC was exposed to several concentrations of ...
Kummer J Alain - - 2007
Several autoinflammatory disorders such as Muckle-Wells syndrome are characterized by mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can assemble to inflammasomes that activate caspase-1, resulting in the processing of pro-inflammatory cytokines IL-1beta and IL-18. The present study was designed to determine which cells and tissues express NALP1 and ...
Troy Tammy-Claire - - 2007
The importance of the epidermal permeability barrier (EPB) in protecting the mammalian species against harmful UV irradiation, microorganism invasion and water loss is well recognized, as is the role of calcium (Ca(2+)) in keratinocyte differentiation, cell-cell contact and the EPB. In a previous study, we reported that the overexpression of ...
Moretti Simona - - 2006
Semaphorins are involved in a wide range of biological processes, including axon guidance, neuronal migration, angiogenesis, cardio- and osteo-genesis. Recently they have also been found to be important for immune response. Sema3A reduces the activation of T cells through its cell-surface receptors, including members of the neuropilin and plexin families. ...
Wjst Matthias - - 2006
Oral vitamin D supplementation has been introduced into modern medicine to prevent rickets without the knowledge that this may have profound immunological consequences. The main vitamin D metabolite calcitriol suppresses dendritic cell maturation and consecutive Th(1) cell development, which has independently described as a key mechanism of allergy development. Animal ...
Kaneko Tomoatsu - - 2008
Dendritic cells are important for the induction of T-lymphocyte-mediated immunity by acting as antigen-presenting cells. We have previously reported that dendritic cells are prevalent in the chronic non-expanding phase of rat apical periodontitis. To characterize these cells further, immunoelectron microscopy with three dendritic cell markers (CD11c, OX6, OX62) was conducted ...
Oberbanscheidt Pia - - 2007
Cells accomplish the non-selective uptake of extracellular fluids, antigens and pathogens by the endocytic process of macropinocytosis. The protein SWAP-70 is a widely expressed, pleckstrin-homology (PH) domain-containing protein that marks a transitional subset of actin filaments in motile cells. Here we report that the protein SWAP-70 associates transiently with macropinosomes ...
Radestock A - - 2007
The two photosensitizers, chlorin e6 and pheophorbide a, were tested in an in vitro model of topical photodynamic therapy (PDT). Both dyes accumulate in HaCaT keratinocytes as verified by fluorescence measurement but pheophorbide a is enriched fivefold more strongly than chlorin e6 after 24 h. HaCaT cells are susceptible to ...
Campinho Marco A - - 2007
Developmental models for skin exist in terrestrial and amphibious vertebrates but there is a lack of information in aquatic vertebrates. We have analysed skin epidermal development of a bony fish (teleost), the most successful group of extant vertebrates. A specific epidermal type I keratin cDNA (hhKer1), which may be a ...
Körver J E M - - 2006
BACKGROUND: The margin zone in spreading psoriatic lesions has frequently been used as a model to study the changes in epidermal proliferation, keratinization and inflammation during the transition from symptomless to lesional skin. However, the dynamics of the changes in the epidermal subpopulations-basal cells, transit amplifying cells and differentiated cells-have ...
Masuda H - - 2006
PURPOSE: The acute influence on the skin of non-ionizing electromagnetic fields in the radiofrequency (RF) range used in mobile telephony has not been widely studied to date. The purpose of this work was to determine whether the cells of hairless rat skin are affected by acute local exposure to Global ...
Zhou Xin - - 2006
We present the design for a hexagonal cell made of quasi-periodic dendritic arranged collections of plasmonic metallic wires that may exhibit a resonant magnetic collective response. When such quasi-periodic dendritic cells are etched on a host medium, they may provide metamaterials with negative effective permeability. We also show that a ...
Kreisel Friederike H - - 2006
In this study, we sorted total bone marrow (BM) into six distinct subsets based on surface expression of CD31 and Ly6C and investigated the capacity of these subsets to acquire characteristics of plasmacytoid dendritic cells (PDCs) after in vitro culture with FMS-like tyrosine kinase 3 ligand (Flt3-L). Cultured CD31(high)/Ly6C(-) cells ...
Zhang Jian - - 2006
Dental caries and pulpitis are the most common bacterial infections in humans. However, the immune responses against bacterial stimulation in dental pulp that is bounded by special hard tissues are poorly understood. We examined the initial immune responses in mouse dental pulp after cusp trimming and acid treatment. Using fluorescence ...
Ko Christine J - - 2006
AIM: In our previous research, bcl-2-positive dendritic cells were seen in increased numbers in suprabasal areas of inverted follicular keratoses (IFKs) compared to seborrheic keratoses (SKs). The purpose of this study was twofold; firstly, to support that these dendritic cells are Langerhans cells and secondly, to contrast the epidermal dendritic ...
Pieri Laura - - 2006
Since during the generation of dendritic cells transforming growth factor (TGF)-beta1 is required to generate specifically Langerhans cells, we have addressed whether TGF-beta1 also affects the number and immunophenotype of Langerhans cells within the epidermis. Isolated human epidermal sheets were cultured as follows: serum free; with serum; serum free with ...
Romani Nikolaus - - 2006
New experimental models and methods have rendered the field of Langerhans cells very lively. An interesting and productive scientific debate as to the functions of Langerhans cells in vivo is currently going on. We have not yet reached the point where the "pros" would weigh out the "cons", or vice ...
Yang Ellen J - - 2006
Interneuron kainate receptor (KAR) activation regulates normal network activity and modulates cell excitability. As a result, determining the subcellular distribution of KARs in a cell-specific manner is a necessary step toward understanding their role in network function. We have functionally mapped synaptic and extrasynaptic dendritic KARs on hippocampal oriens interneurons ...
Hugues Stephanie - - 2006
Induction of T cell priming and tolerance require direct encounters between naïve T cells and dendritic cells (DCs). T cell activation and proliferation occur in both situations, but the concomitant dynamics of DC-T cell contacts differ: the contacts between naïve T cells and DCs are more stable during the induction ...
Jacobs John J L - - 2006
Skin irritants and contact allergens reduce the number of Langerhans cells (LCs). It has been assumed that this reduction is due their migration to the draining lymph node (LN) for initiating immune sensitization in a host. Skin irritation, however, as opposed to contact allergy is not considered to be an ...
Piyawadee Pothiraksanon, 2512-
Thesis (M.Sc.)--Chulalongkorn University, 2002
Hundt Matthias - - 2006
The molecular basis of T cell anergy is not completely understood. We show that in antigen-primed anergic murine CD4(+) T cells the linker for activation of T cells (LAT) is hypophosphorylated upon CD3/CD28 restimulation. Signaling events downstream of LAT (PLCgamma1 phosphorylation and p85 [PI3-K] association) were impaired, whereas upstream events ...
Oldhoff J M - - 2006
BACKGROUND: The atopy patch test (APT) is an in vivo model to study the induction of eczema by inhalant allergens in atopic dermatitis patients. We studied the effect of pretreatment with topical tacrolimus 0.1% on APT in nonlesional skin of patients with atopic dermatitis. METHODS: Nonlesional skin of the back ...
Wat Christina S K - - 2006
Langerhans cell histiocytosis is a disorder characterized by the proliferation of histiocytes of the mononuclear phagocyte system. Cutaneous Langerhans cell histiocytosis can develop as a solitary lesion or more frequently as part of a multisystem disease. This report describes a case of cutaneous Langerhans cell histiocytosis affecting the eyelids, resulting ...
Soni, Sarvjit L.
Electron probe analysis was employed to study the accumulation and distribution of silicon in differentiating epidermal cells of the developing internode of Cyperus alternifolius. The process of silicon accumulation was found to occur from the base to the tip of an elongating internode. The accumulation of silicon by long epidermal ...
Udey Mark C - - 2006
Langerhans cells have long been considered to be prototypic immature dendritic cells. Results of experiments involving genetically engineered mice provide surprising new insights into Langerhans cell function in vivo. Nishibu and colleagues illustrate how these approaches can be used to visualize Langerhans cells in vivo in real time, and to ...
Berlier W - - 2006
BACKGROUND: Heterosexual human immunodeficiency virus (HIV) transmission implies the crossing of the vaginal mucosa by virions present in the semen, potentially using Langerhans cells as transporters. The recruitment of these cells in the mucosa is mediated by the chemokine macrophage inflammatory protein 3alpha (CCL20). The aim of this study was ...
Nadais Ricardo da Fonseca Rda - - 2006
OBJECTIVE: To compare the intraepithelial population of Langerhans' cells (LC) in normal cervix epithelium adjacent to cervical intraepithelial neoplasia grade 3 (CIN 3) and correlate to smoking habit. METHODS: Cases in this study included conization specimens from 48 women affected by CIN 3. The LC count was performed in areas ...
Khosrotehrani Kiarash - - 2006
During pregnancy, maternal cells may enter the fetal circulation and persist until adulthood. The fate of these cells remains unknown. As unexplained T-cell-mediated conditions such as pityriasis lichenoides (PL) may occur in children, we aimed at identifying maternal cells in lesional skin of PL and controls. Archived skin biopsy specimens ...
Ferringer Tammie - - 2006
Proliferations of Langerhans cells can be histologically divided into cytologically benign Langerhans cell proliferations, which include the clinical syndromes of Langerhans cell histiocytosis, and cytologically malignant Langerhans cell sarcoma. We report a Langerhans cell sarcoma in a 33-year-old male that arose on the posterior thigh with subsequent regional lymph node ...
Michalak, Tracy
Fishes in the Superorder Ostariophysi have specialized epidermal club cells that contain an alarm substance. Damage to these cells causes the release of the alarm substance which can serve as a useful indicator of predation risk for nearby conspecifics. The majority of research involving alarm substances has investigated the roles ...
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