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Guo Feng-Jun FJ Department of Obstetrics and Gynaecology, The Second Hospital, Jilin University, Changchun 130041, P.R. - - 2014
The aim of the present study was to investigate the effects of plasmid-mediated RNA interference targeting of cyclooxygenase‑2 (COX‑2) on the biological behaviors of SKOV3 human ovarian cancer cells and to analyze the function of COX‑2 in carcinogenesis and development of ovarian cancer. A COX‑2 small hairpin (sh)RNA sequence was ...
Zhao Hui H Environmental Energy Technologies Division and §Materials Sciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720, United - - 2014
Silicon alloys have the highest specific capacity when used as anode material for lithium-ion batteries; however, the drastic volume change inherent in their use causes formidable challenges toward achieving stable cycling performance. Large quantities of binders and conductive additives are typically necessary to maintain good cell performance. In this report, ...
Anolik Rachel B RB Department of Dermatology, Section of Dermatopathology, Boston University School of Medicine, Boston, - - 2014
: P75 neurotrophin receptor (p75) is a transmembrane protein in the tumor necrosis receptor superfamily useful for the diagnosis of desmoplastic melanomas, desmoplastic trichoepitheliomas, and more recently used for detecting perineural invasion in oral and esophageal squamous cell carcinomas (SCCs). P75 staining in cutaneous SCCs is more controversial with initial ...
Marschalek Nils N Institut für Integrative Neuroanatomie, Charité, Universitätsmedizin Berlin, - - 2014
Niemann Pick type C (NPC1) is a rare fatal hereditary cholesterol storage disease associated with a massive Purkinje cells loss. The mechanisms leading to neurodegeneration are still poorly understood. Different laboratories pointed to hypersensitivity to cytotoxic effects of statins (HMG-CoA reductase inhibitors) in NPC1 and suggested an underlying lack of ...
Li Zhichao Z State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Nanxincun 20, Xiangshan, Haidian, 100093 Beijing, PR China University of Chinese Academy of Sciences, Yuquan Road 19, 100049 Beijing, PR - - 2014
Physalis species show a significant variation in berry size; however, the underlying molecular basis is unknown. In this work, we showed that cell division difference in the ovaries might contribute to the ultimate berry size variation within Physalis species, and that mRNA abundance of Physalis floridana Cell Number Regulator1 (PfCNR1), ...
Zhang Anna Fan - - 2014
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder caused by mutations in the Pkd1 or Pkd2 genes, in which large cysts replace normal kidney tissue, leading to end stage kidney disease. In thus study we have utilized a powerful nanoHPLC-mass spectrometric approach to characterize patterns of normal ...
Cetinbas N N 1] Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada [2] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, - - 2014
Cellular transformation is associated with altered glutamine (Gln) metabolism. Tumor cells utilize Gln in the tricarboxylic acid (TCA) cycle to maintain sufficient pools of biosynthetic precursors to support rapid growth and proliferation. However, Gln metabolism also generates NADPH, and Gln-derived glutamate is used for synthesis of glutathione (GSH). As both ...
Li Weiling W Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. - - 2014
Peptides from scorpion venom have been previously studied for use in the prevention and treatment of various types of cancer in folk medicine. The present study investigated the anti-proliferative effects and mechanisms of the low molecular weight (~3 kDa) BmK scorpion venom peptides (LMWSVP) on human hepatoma (SMMC 7721) and ...
Sommer Cesar A CA Section of Gastroenterology, Department of Medicine, - - 2014
In response to fat intake, enteroendocrine K cells release the hormone glucose-dependent insulinotropic polypeptide (GIP). GIP acts on adipocytes to increase lipid uptake and enhance adipokine secretion, promoting weight gain and insulin resistance. Modulation of intestinal GIP release could therefore represent a therapeutic strategy for the treatment and prevention of ...
Kumar Narender N Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247 667, Uttarakhand, - - 2014
Phthalates are commonly used as plasticizers in a variety of products. Since it has been identified as endocrine-disrupting chemical (EDC), effect of phthalates on human health is a major concern. In this study, we evaluated individual as well as combined mixture effects of three low molecular weight phthalates on the ...
Dokleja Lana L Division of Pharmacology and Toxicology, Faculty of Pharmacy, , Viikinkaari 5E, PO Box 56, FIN-00014 University of Helsinki, Finland. Electronic address: - - 2014
α-Synuclein (aSyn) aggregation, mitochondrial dysfunction and oxidative damage has been shown to be related to the death of dopaminergic neurons in Parkinson's disease (PD). Prolyl oligopeptidase (PREP) is proposed to increase aSyn aggregation, and PREP inhibition has been shown to inhibit the aggregation process in vitro and in vivo. In ...
Wang ChiaChen C School of Medicine, FuJen Catholic University, Xinzhuang Dist., New Taipei City, Taiwan; Department of Dermatology, Cardinal Tien Hospital, Xindian Dist., New Taipei City, - - 2014
Anchorage-independent survival is one of key features for malignant tumor cells. Whether specific gene alterations contributed by anchorage-independency would further affect metastatic phenotypes of melanoma cells was unclear. We adapted suspension culture of melanoma cells to establish anchorage-independency. The suspended melanoma cells lost their invasive abilities in vitro. Specific loss ...
Shah Asima A Department of Food Science and Technology, University of Kashmir, - - 2014
This paper reports the characterization and potential antioxidant activity of β-d-glucan isolated from barley treated with γ-rays. The β-d-glucan was irradiated with 0, 2, 4 and 8kGy by gamma ray. The samples were characterized by Fourier transform-infrared spectroscopy, gel permeation chromatography (GPC) and quantitative estimation by Megazyme β-d-glucan assay kit. ...
Torres-Bugarín Olivia O Grupo Internacional Facultad de Medicina, Universidad Autónoma de Guadalajara, Av. Patria 1201, Lomas del Valle, Zapopan, Jalisco 45129, - - 2014
The aim of this study is to assess the frequency of micronucleated cell (MNC) and nuclear abnormalities (NA) in the buccal mucosa cells of females with anorexia nervosa (AN) or bulimia nervosa (BN), compared with healthy women. Individuals with AN and BN have inadequate feeding and compensatory behaviour to avoid ...
Hadidi Pasha P Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, - - 2014
A recent development in the field of tissue engineering is the rise of all-biologic, scaffold-free engineered tissues. Since these biomaterials rely primarily upon cells, investigation of initial seeding densities constitutes a particularly relevant aim for tissue engineers. In this study, a scaffold-free method was used to create fibrocartilage in the ...
Yang Zhuang - - 2014
Twenty-one novel derivatives of millepachine were synthesized and evaluated for their in vitro anti-proliferative activity. Among them, 8 exhibited the most potent activity with IC50 values of 8-27 nM against panel of cancer cell lines and retained full activity in multidrug resistant cancer cells. Treated cells were arrested in G2/M ...
Sato Eiichi E Department of Orthopaedic Surgery, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan; Department of Orthopedic Surgery, Kikyougahara Hospital, Shiojiri, Nagano, - - 2014
Osteoarthritis (OA) is a group of common, chronic, and painful inflammatory joint diseases. One important finding in OA patients is a remarkable decrease in the molecular weight of hyaluronic acid (HA) in the synovial fluid of affected joints. Therapeutic HA is available to patients in most parts of the world ...
Biswas Tanya T Division of Plant Biotechnology, CSIR-Central Institute of Medicinal & Aromatic Plants, Council of Scientific & Industrial Research, PO CIMAP, Lucknow, 226015, - - 2014
The age-dependent production kinetics of ginsenosides and an anthocyanin pigment in a cell suspension line of Panax sikkimensis was followed in vitro. Highest total saponin content [7.37 mg/g dry weight (DW)] and biomass accumulation (% biomass increase = 209.67) in this line occurred after 3 and 5 weeks of culture, respectively. Accumulation of individual ...
Chen Song S Department of Materials Science and Engineering, University of Florida, Gainesville, FL, 32611, USA; Recording Head Operations, Seagate Technology, Bloomington, MN, 55435, - - 2014
S.-W. Tsang, F. So, and co-workers use charge modulation electroabsorption spectroscopy (CMEAS) to determine the VOC loss in several polymer-fullerene solar cells. Based on their data, they conclude on page 6125 that the VOC loss is due to the low dielectric constants of the polymers. The photovoltage loss is found ...
Wu Junyi J Department of Materials Science and Engineering, Stony Brook University, Stony Brook, New York - - 2014
Using low molecular weight chitosan nanoparticles (CNPs) prepared by an ionic gelation method, the authors report the effect of low-intensity pulsed ultrasound (US) on cell viability and nanoparticle uptake in cultured murine preosteoblasts. Particle size and zeta potential are measured using dynamic light scattering, and cell viability is evaluated using ...
Joshi Suhasini S Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, - - 2014
Mucins are high molecular weight O-glycoproteins that are predominantly expressed at the apical surface of epithelial cells and have wide range of functions. The functional diversity is attributed to their structure that comprises of a peptide chain with unique domains and multiple carbohydrate moieties added during posttranslational modifications. Tumor cells ...
Stout David A DA Center for Biomedical Engineering, School of Engineering, Brown University, 184 Hope St., Box D, Providence RI 02906, USA Department of Mechanical and Aerospace Engineering, California State University, Long Beach, 1250 Bellflower Blvd., Long Beach CA 90840, - - 2014
During a heart attack, the heart's oxygen supply is cut off, and cardiomyocytes perish. Unfortunately, once these tissues are lost, they cannot be replaced and results in cardiovascular disease-the leading cause of deaths worldwide. Advancements in medical research have been targeted to understand and combat the death of these cardiomyocytes. ...
Roy Debarshi D Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, - - 2014
Loss of the endosulfatase HSulf-1 is common in ovarian cancer, upregulates heparin binding growth factor signaling and potentiates tumorigenesis and angiogenesis. However, metabolic differences between isogenic cells with and without HSulf-1 have not been characterized upon HSulf-1 suppression in vitro. Since growth factor signaling is closely tied to metabolic alterations, ...
Ebrahim Fawzi F Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research, School of Medicine, Faculty of Health, Deakin University, Geelong, Victoria, - - 2014
With the successful clinical trials, multifunctional glycoprotein bovine lactoferrin is gaining attention as a safe nutraceutical and biologic drug targeting cancer, chronic-inflammatory, viral and microbial diseases. Interestingly, recent findings that human lactoferrin oligomerizes under simulated physiological conditions signify the possible role of oligomerization in the multifunctional activities of lactoferrin molecule ...
Wagner Matthew A MA Harvard University, School of Engineering and Applied Sciences, Cambridge, - - 2014
This work examines pluronic F-127 poloxamer for cell protection during injection through a syringe needle. Direct cell injection is a minimally invasive method for cell transplantation; however, it often results in poor cell viability. We proposed that encapsulating cells in this hydrogel would protect cells from detrimental mechanical forces during ...
Majeed R R 1] Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India [2] Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, - - 2014
Betulinic acid (BA) is a pentacyclic triterpenoid natural product reported to inhibit cell growth in a variety of cancers. However, the further clinical development of BA got hampered because of poor solubility and pharmacological properties. Interestingly, this molecule offer several hotspots for structural modifications in order to address its associated ...
Paulus Jeremiah D JD Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States of - - 2014
Mutations in Optineurin have been associated with ALS, glaucoma, and Paget's disease of bone in humans, but little is known about how these mutations contribute to disease. Most of the cellular consequences of Optineurin loss have come from in vitro studies, and it remains unclear whether these same defects would ...
Wei Wenjie - - 2012
PURPOSE: We sought to determine if bladder cycling is required for remodeling during fetal development. MATERIALS AND METHODS: For this study 5 fetal sheep bladders were harvested after 2 weeks of urinary diversion, initiated at approximately 90 days of gestation. Six unoperated sheep bladders of approximately 105 days of gestational ...
Verma Nisha - - 2012
More than 90 % of all bladder cancers are transitional cell carcinomas arising from the cells lining the inside of the hollow organ (uroepithelium). Cell cultures from primary urinary bladder epithelial cells (PUBEC) of pigs were established to assess the uptake, intracellular concentration, and subcellular distribution of the environmental pollutant benzo(a)pyrene ...
Gu Gang-Li - - 2012
Introduction: This study aims to investigate whether mesothelial cells could function as seed cells to construct tissue-engineered peritoneum-like tissue for urethral reconstruction in a rabbit model. Materials and Methods: Bladder acellular matrices were prepared and trimmed to 1.5 × 1 cm. Nine male rabbits underwent omentum biopsy and autologous mesothelial ...
Wolk M - - 2012
The immunohistochemical features of fetal haemoglobin cells and their distribution patterns in solid tumours, such as colorectal cancer and blastomas, suggest that fetal haemopoiesis may take place in these tumour tissues. These locally highly concentrated fetal haemoglobin (HbF) cells may promote tumour growth by providing a more efficient oxygen supply. ...
Monaghan Kevin P - - 2012
PURPOSE: The bladder wall comprises a complex array of cells, including urothelium, smooth muscle, nerves and interstitial cells. Interstitial cells have several subtypes based on site, morphology and differential expression of markers such as anti-vimentin and anti-KIT. We examined whether a subpopulation of interstitial cells immunopositive for PDGFRα exists in ...
Chen Lin - - 2012
PURPOSE: A mechanical stimulus on detrusor tissue is critical to bladder outlet obstruction progression and functional bladder tissue engineering. A hypothesis is that mechanical stimulus triggers human bladder smooth muscle cell proliferation. To help better understand this relationship of bladder function to growth at the cellular level we used a ...
Yang Shucai - - 2012
Bladder cancer is the most common neoplasm in the urinary system. This study assesses arctigenin anti-tumor activity in human bladder cancer T24 cells in vitro and the underlying molecular events. The flow cytometry analysis was used to detect cell-cycle distribution and apoptosis. Western blotting was used to detect changes in ...
Negri Melyssa - - 2012
Candida tropicalis infection is strongly associated with the presence of biofilms in urinary catheters. Thus, the aim of this work was to study the behaviour of C. tropicalis in biofilms of different ages (24-120h) formed in artificial urine (AU) and their effect in human urinary bladder cells (TCC-SUP). Reference strain ...
Jou Yeong-Chin - - 2012
In a recent study on hepatocellular carcinoma (HCC), we have shown that the transcription factors Myeloid Zinc Finger-1 (MZF-1) and Ets-like-protein 1 (Elk-1) are significantly related to protein kinase C alpha (PKCα) expression. The purpose of this study was to determine the correlation of the expression of PKCα with the ...
Ardelt Peter - - 2012
The LIM and SH3 (LASP)-1 protein is a focal adhesion protein that has been linked to oncogenesis. The aim of this study was to evaluate the diagnostic use of the detection of LASP-1 in tumor specimens and in urine for noninvasive detection of transitional cell carcinoma (TCC). Immunohistochemical staining for ...
Smith Edward J EJ Department of Neuroscience, King's College London, Institute of Psychiatry, London, - - 2012
Stroke remains one of the most promising targets for cell therapy. Thorough preclinical efficacy testing of human neural stem cell (hNSC) lines in a rat model of stroke (transient middle cerebral artery occlusion) is, however, required for translation into a clinical setting. Magnetic resonance imaging (MRI) here confirmed stroke damage ...
Yamamoto Tokunori - - 2012
Objectives:  To report a novel cell therapy using autologous adipose tissue-derived regenerative cells for male stress urinary incontinence caused by urethral sphincteric deficiency, and the outcomes in the initial cases undergoing periurethral injection of adipose tissue-derived regenerative cells. Methods:  Three patients with moderate stress incontinence after radical prostatectomy and holmium ...
Mishra Vivek - - 2012
The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, respectively. ...
Montagner Isabella Monia - - 2012
OBJECTIVES: A previously described hydrosoluble paclitaxel-hyaluronan bioconjugate appears particularly well suited for treatment of superficial bladder cancer because of its in vitro cytotoxic profile against urothelial carcinoma (UC) cell lines and in vivo biocompatibility. The aim of this work was to assess the mechanism of action of the bioconjugate in ...
Valentine Beth A - - 2012
Adult onset progressive alopecia and leukotrichia developed in 2 registered black Angus cows, aged 6 and 7 years. Histopathologic findings in skin were prominent melanin clumping and degeneration of matrix cells with formation of giant multinucleate cells within hair bulbs, accompanied by peribulbar melanin incontinence and fibrosis and dystrophic hair ...
Sun Yubo - - 2012
PURPOSE OF REVIEW: The purpose of this review is to discuss recent advances in the understanding of the nature of meniscal calcification and its relationships with meniscal degeneration and cartilage lesions in osteoarthritis. RECENT FINDINGS: Calcium crystals are universally present in hyaline articular cartilage, as well as the meniscus of ...
Claudino Mário Angelo - - 2012
Sickle cell anemia is one of the best studied inherited diseases, and despite being caused by a single point mutation in the HBB gene, multiple pleiotropic effects of the abnormal hemoglobin S production range from vaso-occlusive crisis, stroke, and pulmonary hypertension to osteonecrosis and leg ulcers. Urogenital function is not ...
Quiroga-Garza Gabriela - - 2012
Objective: We identified unique vegetable cell-like structures in urinary diversion specimens. This study aimed to describe their cytomorphology and prevalence and to investigate the possible origin of these contaminants. Study Design: A 10-year retrospective review of urinary diversion urine specimens with reported vegetable cell-like structures was performed. Data regarding patient ...
Brassesco Maria S - - 2012
Bladder cancer is a common malignancy worldwide. Despite the increased use of cisplatin-based combination therapy, the outcomes for patients with advanced disease remain poor. Recently, altered activation of the PI3K/ Akt/mTOR pathway has been associated with reduced patient survival and advanced stage of bladder cancer, making its upstream or downstream ...
Pinto-Leite Rosário - - 2012
The purpose of this study was to determine whether everolimus, a rapamycin derivative, might significantly enhance the cytotoxicity of gemcitabine, an antitumor drug, in two human bladder-cancer cell lines. Human bladder-cancer T24 and 5637 cells were incubated with gemcitabine and everolimus in a range of concentrations either alone or in ...
Mota-Ortiz Sandra Regina SR Laboratory of Neural Basis of Behavior, City University of Sao Paulo, UNICID, Sao Paulo, SP 03071-000, - - 2012
Previous studies using morphine-treated dams reported a role for the rostral lateral periaqueductal gray (rlPAG) in the behavioral switching between nursing and insect hunting, likely to depend on an enhanced seeking response to the presence of an appetitive rewarding cue (i.e., the roach). To elucidate the neural mechanisms mediating such ...
Keichel S - - 2011
BACKGROUND In patients diagnosed with deep infiltrating endometriosis (DIE), foci of endometriosis are detected in mesorectal lymph nodes (LNs) after segmental bowel resection and in pelvic sentinel LNs. Lymph vessels (LVs) seem to be the possible routes for the dissemination of endometriotic cells from DIE-lesions to LN. Therefore, we conducted ...
Pagliari Carla - - 2011
Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate ...
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