Search Results
Results 1 - 50 of 1497
1 2 3 4 5 6 7 8 9 10 >
Ahmadi Farrokhlagha F Department of Nephrology, Imam Khomeni Hospital, Nephrology Research Center, Tehran University of Medical Sciences , Tehran , Iran - - 2014
Abstract Background: Residual renal function (RRF) plays a key role in the follow-up of the patients undergoing chronic ambulatory peritoneal dialysis (CAPD). Available methods for measurement of RRF are cumbersome and rarely used, and alternatively, cystatin C-derived equations have been proposed. Methods: Seventy-six adult CAPD patients were recruited. RRF was ...
Kim Jae-Jung JJ Asan Institute for Life Sciences, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 138-736, - - 2014
Kawasaki disease (KD) is an acute self-limiting form of vasculitis that afflicts infants and children and manifests as fever and signs of mucocutaneous inflammation. Children with KD show various laboratory inflammatory abnormalities, such as elevations in their white blood cell (WBC) count, C-reactive protein (CRP) level, and erythrocyte sedimentation rate ...
Asano Takeshi T Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital, Inzai City, Chiba Prefecture, - - 2014
Background:In acute encephalopathy, deterioration of the condition can be rapid and early intervention is essential to prevent progression of the disease. However, in the acute period, differentiating acute encephalopathy from febrile seizures is difficult. Thus, an early diagnostic marker has been sought to enable early intervention. Proton nuclear magnetic resonance ...
Kondelkova Katerina K Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech - - 2014
Toll-like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T-cell driven immune-mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The ...
Naumnik W W Department of Lung Diseases, Medical University of Bialystok, 14 Zurawia St., 15-540, Bialystok, Poland, - - 2014
Recently, it has been reported that lack of cathepsins prevent the development of lung granulomas in a mouse model of Besnier-Boeck-Schaumann (BBS) disease, sarcoidosis. There is no data about cathepsin V (Cath V) in bronchoalveolar lavage fluid (BALF) in humans. Endostatin is a novel inhibitor of lung epithelial cells. The ...
Peraldo Neia Caterina C Department of Oncology, University of Turin Medical School, IRCCS-Candiolo, Turin, - - 2014
ROS1 rearrangements have been detected in a variety of tumors and are considered as suitable targets of anticancer therapies. We developed a new, quick, specific, and sensitive PCR test to screen for the FIG-ROS1 fusion and applied it to a series of Italian patients with bile duct carcinoma (BTC). Formalin-fixed, ...
Nalin Tatiéle T Post-Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, - - 2014
Uncooked cornstarch (UCCS) is a widely used treatment strategy for patients with hepatic glycogen storage disease (GSD). It has been observed that GSD-patients display different metabolic responses to different cornstarches. The objective was to characterize starch fractions and analyze the digestion of different starches in a dynamic gastrointestinal in vitro ...
McNamara Nancy A NA Francis I. Proctor Foundation, University of California, San Francisco, 513 Parnassus, Box 0412, San Francisco, California, 94143-0412, United States - - 2014
Purpose: Sjögren's syndrome (SS) is a common autoimmune disease that can cause aqueous-deficient dry eye and the aberrant differentiation of ocular mucosal epithelial cells toward a lineage that is pathologically keratinized and skin-like. PAX6 is the master regulator of corneal lineage commitment. Recently, we showed a functional role for PAX6 ...
Vlachos Sotirios S Second Department of Surgery, Medical School, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100, Greece; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, - - 2014
Several studies state that a test of severity early in the course of acute pancreatitis is still needed. In this prospective study, an assay of the biomarkers M30 and M65 as well as of interleukin 17 (IL-17) is investigated. One hundred and fifty patients and 70 controls were evaluated. The ...
Caldwell Julie M JM Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, - - 2014
The definition of eosinophilic gastritis (EG) is currently limited to histologic EG based on the tissue eosinophil count. We aimed to provide additional fundamental information about the molecular, histopathologic, and clinical characteristics of EG. Genome-wide transcript profiles and histologic features of gastric biopsy specimens, as well as blood eosinophil counts, ...
Marsh Anne A Department of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA; Children's Hospital Oakland Research Institute, Oakland, CA, - - 2014
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 2·3-fold higher ...
Li Ying Ying YY Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Aberrant airway epithelial remodeling is one of the cardinal histopathologic features of inflammatory airway diseases, but whether it alters the mucociliary apparatus remains unknown. We sought to investigate the morphologic pattern of motile cilia and ciliogenesis-associated makers in hyperplastic nasal epithelium from nasal polyps (NPs) both in vivo and in vitro. Biopsy ...
Kim Sun Min SM Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of - - 2014
Abstract Objective Acute histologic chorioamnionitis (HCA) is associated with increased risk of perinatal mortality and morbidity. The purpose of this study was to determine the relationship between the intensity of intra-amniotic inflammation (IAI) and the severity of acute HCA in preterm gestation. Methods The relationship between the intensity of IAI ...
Martin Brock A BA Departments of *Pathology †Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition ‡Department of Pediatrics, Lucile Packard Children's Hospital and Stanford University Medical Center, Stanford, - - 2014
Congenital enteropathies are rare disorders with significant clinical consequences; however, definitive diagnosis based on morphologic assessment of duodenal biopsies with routine stains alone is often impossible. To determine the role of immunohistochemistry (IHC) in the evaluation for microvillous inclusion disease, congenital tufting enteropathy (intestinal epithelial dysplasia), and enteroendocrine cell dysgenesis, ...
Hou Shengping S The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Ophthalmology, Chongqing, China Chongqing Eye Institute, Chongqing, - - 2014
Considering the phenotypical consequences and association of C4 copy number variation (CNV) with various autoimmune diseases, we aimed to examine C4 CNVs for 1027 patients with Vogt-Koyanagi-Harada (VKH) syndrome and 2083 controls. C4 CNVs were examined by real-time PCR for 1027 patients with VKH and 2083 controls. Peripheral blood mononuclear ...
Joshi D D Department of Gastroenterology, University College London Hospital, - - 2014
A 64 year-old Caucasian gentleman presented with abnormal liver biochemistry (ALP 212 IU/L, ALT 75 IU/L, GGT 301 IU/L, albumin 38 g/L bilirubin 55 umol/L, INR 1.1). He was asymptomatic with no history of weight loss. He had a history of well controlled ulcerative colitis. Axial imaging and an ERCP ...
Martins Paulo Roberto Juliano PR Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. Electronic address: - - 2014
Changes in weight/height ratio, delayed sexual maturation, hypogonadism and impaired fertility have been demonstrated in sickle cell disease (SCD). This study aimed to evaluate the clinical and laboratory views of the Leydig cells function after stimulation with hCG in adults with sickle cell disease. We studied 15 patients with SCD ...
Ozcan Erkan E Department of Periodontology, Center of Oral Health, Gülhane Military Hospital, Ankara, Turkey, - - 2014
In recent years, adipokines have been reported to play an important role in chronic inflammatory diseases. In this study, our aim was to investigate the salivary levels of visfatin, chemerin, and progranulin and their relationship with periodontal health and disease. A total of 72 patients were included in the study, ...
Mroczko Barbara B Department of Neurodegeneration Diagnostics, Medical University of Białystok, Poland Department of Biochemical Diagnostics, University Hospital in Białystok, - - 2014
Background: The correlations between pathology of neurodegenerative diseases, especially Alzheimer's disease (AD), and concentrations of neuronal calcium sensor proteins, such as visinin-like protein 1 (VILIP-1), in cerebrospinal fluid (CSF) have been discussed in the literature but its utility as biomarker of AD in comparison with mild cognitive impairment (MCI) has ...
Vayá Amparo A Department of Clinical Pathology, Hemorheology and Haemostasis Unit, La Fe University Hospital, Valencia, Spain - - 2014
There is no information about a possible association of red blood cell distribution width (RDW) with cryptogenic stroke (CS). We aimed to analyze the association of RDW with CS. One hundred and sixty-three patients with CS were included along with 186 healthy controls. Fibrinogen, leukocytes, hemoglobin, and erythrocyte indices were ...
Steel Ryan R School of Biological Sciences, Victoria University of Wellington, Wellington, New - - 2014
Propranolol is increasingly used to treat problematic infantile haemangioma (IH), although its molecular mechanisms remain unclear. A key feature of propranolol therapy is the decreased deposition of fibrofatty residuum compared with spontaneously involuting IH. This study investigated the molecular consequences of propranolol treatment for IH in vivo. Immunohistochemical and terminal ...
Gluba-Brzózka Anna - - 2014
Epidemiological studies have shown that chronic kidney disease (CKD) is an important risk factor for atherosclerosis and cardiovascular disease (CAD). The aim of the study was to determine markers of increased risk of CAD and to achieve a better understanding of agents implicated in the process of atherosclerosis in CKD ...
Yang Dong D Department of Otolaryngology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, - - 2014
This study was conducted to determine the concentration of EPCs in patients with ARHL. Twenty patients with ARHL were evaluated. The number of EPCs was analyzed by flow cytometry analysis of peripheral blood CD34(+)/CD133(+) cells. The concentration of circulating EPCs, both for CD34(+)/CD133(+) cells, was significantly lower in ARHL patients ...
Mazzawi Tarek T Section for Gastroenterology, Department of Medicine, Stord Helse‑Fonna Hospital, Stord, - - 2014
The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated by these cells. Furthermore, it has been established that gut endocrine cells interact with the gut lumen contents, ...
Figuères Marie-Lucile ML Department of Pathology, Hôpital Necker, AP-HP, Paris, France - - 2014
Dense deposit disease is characterized by dense deposits in the glomerular and tubular basement membranes. We report 3 cases with long-term follow-up differing in histologic pattern and clinical evolution. Clinical and histologic data were collected between 1976 and 2012. Age at the first manifestations was 6, 11, and 23 years, ...
Moon Myung-Sang MS Department of Orthopedic Surgery and Traumatology, Cheju Halla General Hospital, Jeju, - - 2014
To assess the preoperative nutritional status of patients with various disorders and to provide data for pre- and postoperative patient management plans, particularly in the elderly. There is no published information on age-matched and disease-matched preoperative nutritional/immunologic status for orthopedic patients, especially in the elderly, in Jeju. In total, 331 ...
Ramos Laura L Department of Endocrinology, University Hospital "Marques de Valdecilla", University of Cantabria, 39008, Santander, Cantabria, Spain, - - 2014
Ectopic calcifications and even bone formation have been linked to GNAS gene mutations. A 51-year-old Caucasian female had been diagnosed of pseudo-pseudohypoparathyroidism (PPHP) in 1989. She has always had normal serum parathyroid hormone, calcium, and phosphorus levels. A non-contrast computed tomography of the head was done in 2013 and it ...
Kumar N S Satish - - 2014
Bio-impedance is the measure of impedance of the body. Impedance consists of resistance and reactance. Phase angle (PA) is the tan value of the ratio of reactance versus resistance. PA depends on cell membrane integrity and on body cell mass. Earlier studies have shown a correlation between PA values and ...
Krul Sébastien P J SP Heart Center, Department of Experimental Cardiology, Cardiology and Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
In patients with atrial fibrillation (AF), the autonomic nervous system is supposed to play an role in triggering AF; however, little is known of the effect on atrial conduction characteristics. The purpose of this study was to study the effect of ganglionic plexus (GP) stimulation during sinus rhythm on atrial ...
Van Vugt Floris T FT Institute of Music Physiology and Musicians' Medicine, University of Music, Drama, and Media Hanover Hanover, Germany ; Lyon Neuroscience Research Center, CNRS-UMR 5292, INSERM U1028, University Claude Bernard Lyon-1 Lyon, - - 2014
Music-supported therapy has been shown to be an effective tool for rehabilitation of motor deficits after stroke. A unique feature of music performance is that it is inherently social: music can be played together in synchrony. The present study explored the potential of synchronized music playing during therapy, asking whether ...
Ma Jian-Da JD Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yan Jiang West Road, Guangzhou 510120, - - 2014
Objective. To explore the correlation between matrix metalloproteinase- (MMP-) 3 and histological synovitis in rheumatoid arthritis (RA). Methods. Serum MMP-3 of 62 patients with active RA was detected by ELISA. Serial synovial tissue sections from all RA patients, 13 osteoarthritis, and 10 orthopedic arthropathies patients were stained with hematoxylin and ...
Ohara Minami M Department of Biopharmaceutics, Meiji Pharmaceutical University, Tokyo, - - 2014
To clarify pharmacokinetic-pharmacodynamic (PK-PD) factors associated with the over-anticoagulation response in Asians during warfarin induction therapy, population PK-PD analyses were conducted in an attempt to predict the time-courses of the plasma S-warfarin concentration, Cp(S), and coagulation and anti-coagulation (INR) responses. In 99 Chinese patients we analyzed the relationships between dose ...
Shahali Y Y Armand Trousseau Hospital, Biochemistry and Molecular Biology D epartment, Allergy & Environment Group, Paris, - - 2014
Cypress pollen represents the primary cause of respiratory allergies in Mediterranean areas. Patients allergic to Cupressus sempervirens pollen (Cups) (CPA) can be discriminated on the basis of the immunoglobulin E (IgE) binding to a basic 14 kDa protein (BP14) or to high-molecular-weight (HMW) glycoproteins only. Specific IgE repertoires of two ...
Najafian Bita B Department of Pediatrics, Islamic Azad University, Pharmaceutical Science Branch, Tehran, - - 2014
Chronic bronchiolitis is the most important problems of chemical victims of mustard gas. Diverse studies suggest that substance P (SP) as a member of tachykinin neuropeptides, has a significant role in the neurogenic inflammation processes of the airways and lungs. We aimed to determine the serum level of SP in ...
Saito Ryoko R Department of Pathology, Tohoku University School of - - 2014
Targeted anticancer therapies have been developed to interfere with specific target molecules including those of downstream pathways required for tumor growth and progression. Mammalian target of rapamycin (mTOR) has been considered as one of the target molecules of cancer growth, and its inhibitors have been reported to exert an anticancer ...
Matsui Masaru M First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, - - 2014
Systemic reactive AA amyloidosis is a life-threatening complication of chronic inflammatory diseases. Anti-interleukin-6 receptor, tocilizumab (TCZ), has been shown to improve clinical symptoms of patients with AA amyloidosis, accompanied with regression of the amyloid deposition. We report a case of AA amyloidosis evaluated by histology of multiple organs before and ...
Gaowa Saren S 0000-0003-4620-0860 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, - - 2014
This prospective cohort study is to verify the hypothesis that the balance of Th17 and Treg cells frequencies in the peripheral circulation is disturbed in patients with varying degrees of connective tissue diseases-associated pulmonary arterial hypertension (CTD-aPAH) and to prove the influence of Th17/Treg imbalance on prognosis. We detected the ...
Messingham Kelly N KN Department of Dermatology, University of Iowa, Iowa City, Iowa, United States of - - 2014
Bullous pemphigoid (BP) is an autoimmune blistering disease mediated by autoantibodies targeting BP180 (type XVII collagen). Patient sera and tissues typically have IgG and IgE autoantibodies and elevated eosinophil numbers. Although the pathogenicity of the IgE autoantibodies is established in BP, their contribution to the disease process is not well ...
Zhang Yaping Y 1. Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, - - 2014
Lung cancer (LC) is the deadliest cancer, with earlier stage patients having a better opportunity of long-term survival. The goal of this study is to screen less-invasive and efficient biomarkers for early detection of non-small cell LC (NSCLC). We performed the simultaneous quantitative detection of six serum unsaturated free fatty ...
Yamakawa Hideaki H Respiratory Medicine, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, - - 2014
A 61-year-old woman being treated with methotrexate (MTX) 8-10 mg/week and prednisolone 2.5 mg/day for rheumatoid arthritis presented with a 1-week history of increasing fever and dry cough. The patient deteriorated with administration of antibiotics. Chest CT scan showed bilateral diffuse ground-glass opacities. Analysis of bronchoalveolar lavage fluid (BALF) revealed marked neutrophilia ...
Nilsson Lennart L Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Department of Cardiology, Linköping University, Linköping, - - 2014
Elevations in soluble markers of inflammation and changes in leukocyte subset distribution are frequently reported in patients with coronary artery disease (CAD). Lately, the neutrophil/lymphocyte ratio has emerged as a potential marker of both CAD severity and cardiovascular prognosis. The aim of the study was to investigate whether neutrophil/lymphocyte ratio ...
Vaidya Seema - - 2013
Hereditary Ectodermal Dysplasia is an inherited disorder commonly involving skin, teeth, hair, and nails. We have observed ectodermal dysplasia (EDs) in 11 individuals over two generations in one family. Smooth, dry, thin skin was seen in most affected individuals. All had fine, slow-growing scalp hair and body hair and some ...
Faller Bernadette - - 2013
BACKGROUND: Reasons underlying dialysis decision-making in Octogenarians and Nonagenarians have not been further explored in prospective studies. METHODS: This regional, multicentre, non-interventional and prospective study was aimed to describe characteristics and quality of life (QoL) of elderly (>=80 years of age) with advanced chronic kidney disease (stage 3b-5 CKD) newly ...
Sulli Alberto - - 2013
OBJECTIVE: This study evaluates possible correlations between the pattern of antinuclear antibodies (ANA) on indirect immunofluorescence (IIF) testing and nailfold microangiopathy stage (early, active, and late stage) in systemic sclerosis (SSc). Patients with SSc were followed prospectively to monitor progression of microvascular damage. METHODS: The ANA pattern on IIF was ...
Skoog Katrina K University of Florida School of Medicine, Gainesville, FL, - - 2013
Polycythemia vera is defined as a chronic myeloproliferative disorder characterized by increased red blood cell count. There have been no reports on mesenteric thrombosis resulting from iatrogenic polycythemia. We present a patient with a history of non-small cell lung cancer undergoing maintenance oral chemotherapy on tarceva and adjunctive use of ...
Carneiro Jamille Nascimento - - 2012
Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. Its prevalence in patients with psoriasis varies from 7 to 42% but its exact prevalence is unknown. Considering the lack of national data related to its diagnosis in patients with psoriasis, this study aims to describe the clinical, laboratorial and radiological ...
Tanouchi Tetsu T Department of Orthopedic Surgery, Gunma Spine Center (Harunaso Hospital), 878-1 Kamitoyooka, Takasaki, Gunma 370-0871, Japan. - - 2012
Mutilating-type rheumatoid arthritis, the most aggressive type of rheumatoid arthritis, is frequently associated with destructive cervical involvement, both at the high-cervical and subaxial levels, causing significant neurological deficit, and their natural course of the disease and the survival are discouraging. For such cases, we have been actively performing occipito-thoracic fusion ...
Kretapirom K K Department of Oral and Maxillofacial Radiology, Tokyo Medical and Dental University, Tokyo, - - 2013
The aim of this study was to investigate characteristic MRI findings of rheumatoid arthritis (RA) in the temporomandibular joints (TMJs). 61 patients (122 TMJs) with RA in the TMJ and 50 patients (100 TMJs) with temporomandibular disorder (TMD) were included in this study. MR images of these patients were assessed ...
Shibuya Naohiro - - 2012
Insertional Achilles tendinosis is a condition where a patient complains of isolated pain at the Achilles tendon insertion site due to intratendinous degeneration. It has been suggested that this condition is associated with cavus foot deformity. However, to our knowledge, there is no study that has confirmed this observation. We ...
Kojima Kentaro - - 2012
PURPOSE: Sarcoidosis is an idiopathic inflammatory disorder involving multiple organs, and ocular manifestation (represented by granulomatous uveitis) is one of the common features. A well-known immunologic feature in sarcoidosis is an increased CD4+ helper T-cell type 1 lymphocyte subset in bronchoalveolar lavage (BAL) fluid. The current study investigated the vitreous ...
1 2 3 4 5 6 7 8 9 10 >