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Hosokawa Kohei K Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, - - 2014
Trisomy 8 (+8), one of the most common chromosomal abnormalities found in patients with myelodysplastic syndromes (MDS), is occasionally seen in patients with otherwise typical aplastic anemia (AA). Although some studies have indicated that the presence of +8 is associated with the immune pathophysiology of bone marrow (BM) failure, its ...
Löffler Christian C From the Department of Rheumatology, Nephrology, and Oncology, Klinikum Ludwigshafen, Ludwigshafen; Department of Nephrology, Hypertensiology, Rheumatology, University Hospital Mannheim, Mannheim; Center of Psychological Psychotherapy, University of Heidelberg, Heidelberg, Germany. C. Löffler, MD, Department of Rheumatology, Nephrology, and Oncology, Klinikum Ludwigshafen, University Hospital Mannheim, University of Heidelberg; H. Sattler, MD; L. Peters, MD, Department of Rheumatology, Nephrology, Oncology, Klinikum Ludwigshafen; U. Löffler, Dipl Psych, Center of Psychological Psychotherapy, University of Heidelberg; M. Uppenkamp, MD, PhD, Department of Rheumatology, Nephrology, Oncology, Klinikum Ludwigshafen; R. Bergner, MD, Department of Rheumatology, Nephrology, and Oncology, Klinikum Ludwigshafen, University Hospital Mannheim, University of Heidelberg. Address correspondence Dr. C. Löffler, Klinikum Ludwigshafen, Bremserstr. 79, D-67067 Ludwigshafen, Germany. E-mail: christianloeffler@gmx.de. Accepted for publication October 1, - - 2014
Differentiating gout, calcium pyrophosphate deposition disease (CPPD), and non-crystal-related inflammatory arthropathies (non-CRA) is essential but often clinically impossible. The sonographic double contour (DC) sign may have good specificity for gout in highly specialized centers, but it can be challenging to use it to distinguish gout from cartilage hyperenhancements in CPPD. ...
Koal Therese T BIOCRATES Life Sciences AG, Innsbruck, - - 2014
Alzheimer's disease (AD) is a severe and chronic neurodegenerative disorder of the brain. The laboratory diagnosis is limited to the analysis of three biomarkers in cerebrospinal fluid (CSF): amyloid-β42 (Aβ42), total tau, and phospho-tau-181 (P-tau-181). However, there is a need to find more biomarkers in CSF that can improve the ...
Seeburger Jeffrey L JL Merck Research Laboratories, Merck & Co., Inc., Whitehouse Station, NJ, - - 2014
Cerebrospinal fluid (CSF) amyloid-β (Aβ) and tau have been studied as markers of Alzheimer's disease (AD). Combined Aβ42 and t-tau distinguishes AD from healthy controls with a sensitivity and specificity (sens/spec) near 89% across studies. This study examined these markers in the homogeneous OPTIMA cohort, using extensive longitudinal follow up ...
Shirai Yuichiro Y Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, - - 2014
Objective. To clarify the role of pentraxin 3 (PTX3), a multi-functional pattern recognition protein that can suppress fibroblast growth factor-2 (FGF2), in systemic sclerosis (SSc)-related vasculopathy. Methods. This study assessed 171 SSc patients and 19 age- and sex-matched healthy control subjects. Circulating PTX3 and FGF2 levels were measured by enzyme ...
Lörinc E E Department of Laboratory Medicine, Lund University and Skåne University Hospital, Malmö, - - 2014
To evaluate the presence of multilayered epithelium (ME) and to compare the distribution, size and morphology of the oesophageal submucosal glands (SMG) beneath reflux exposed metaplastic columnar mucosa with those of normal squamous epithelium in patients with columnar lined oesophagus (CLO). In 8 oesophageal resection specimens, the SMG of the ...
Seeger Harald H Division of Nephrology, University Hospital, Zurich, - - 2014
Introduction: Simple peritoneal fibrosis and encapsulating peritoneal sclerosis (EPS) are important lesions in the peritoneum of patients on peritoneal dialysis (PD). We have previously described a population of podoplanin-positive myofibroblasts in peritoneal biopsies from patients with EPS. Platelet-derived growth factor receptor-β (PDGFRβ) is a marker of pericytes, and PDGFs might ...
Modi Sagar S Departments of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, - - 2014
The functional significance of basal ganglia calcification (BGC) in idiopathic hypoparathyroidism (IH) is not clear. To assess the effect of BGC on glucose metabolism and dopaminergic function in IH. (18) F-FDG and (99m) Tc-TRODAT-1 nuclear imaging were performed in 35 IH patients with (n = 26) and without (n = ...
Laustsen Julie K - - 2014
IntroductionOX40 and its ligand OX40L are key components in the generation of adaptive memory response and provide necessary co-stimulatory signals for activated effector T cells. Here we investigate the dual roles of the membrane and soluble (s) forms of OX40 and OX40L in plasma and synovial fluid and their association ...
Lee Annemarie L AL Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia. Physiotherapy Department; Institute for Breathing and Sleep, Austin Health, Melbourne, Victoria, Australia. annemarie.lee@westpark.org - - 2014
Acid gastroesophageal reflux is a common problem in non-cystic fibrosis bronchiectasis and COPD. Invasive methods are used to diagnose gastroesophageal reflux, but the ability to detect pulmonary microaspiration of gastric contents using this method is unclear. A noninvasive option to detect pulmonary microaspiration is to measure pepsin in exhaled breath ...
Salmasi Vafi V Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Current address: Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, - - 2014
Background: Although uncommon, esthesioneuroblastomas may produce clinically significant amounts of catecholamines. Methods: We report a patient with a catecholamine-secreting esthesioneuroblastoma who developed intraoperative hypertensive crisis. Results: A patient with history of hypertension was referred to our skull base center for management of a residual esthesioneuroblastoma. A staged endonasal endoscopic approach ...
Ghosh Sujal S Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Moorenstraße 5, 40225, Duesseldorf, - - 2014
In patients with underlying immunodeficiency, Epstein-Barr virus (EBV) may lead to severe immune dysregulation manifesting as fatal mononucleosis, lymphoma, lymphoproliferative disease (LPD), lymphomatoid granulomatosis, hemophagocytic lymphohistiocytosis (HLH) and dysgammaglobulinemia. Several newly discovered primary immunodeficiencies (STK4, CD27, MAGT1, CORO1A) have been described in recent years; our group and collaborators were able ...
Duncker Tobias T Department of Ophthalmology, Columbia University, 160 Fort Washington Ave., New York, NY, 10032, United - - 2014
Purpose: Short-wavelength (SW) fundus autofluorescence (AF) is considered to originate from lipofuscin in retinal pigment epithelium (RPE) and near-infrared (NIR) AF from melanin. In patients with recessive Stargardt disease (STGD1), we correlated SW-AF and NIR-AF with structural information obtained by spectral domain optical coherence tomography (SD-OCT). Methods: Twenty-four STGD1 patients ...
Abe Masanori M Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan, - - 2014
Accurately evaluating liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) is important for identifying those who may develop complications. The aims of this study were (1) to measure serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP) using the glycan sugar chain-based immunoassay and (2) to compare the results ...
de Queirós Andréa Simone Siqueira AS Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, Recife-PE, Recife, Pernambuco, CEP 50670-901, Brazil, - - 2014
The formation of intrapulmonary vascular dilations (IPVD) is the key event for the onset of hepatopulmonary syndrome, vascular changes secondary to portal hypertension that leads to hypoxemia. The diagnosis of IPVD can be made by contrasted transthoracic echocardiography or scintigraphy with technetium-macroaggregated albumin-((99m)Tc-MAA)-that is a sensitive and specific diagnostic method ...
Cai Michael Mx MM Department of Nephrology, The Royal Melbourne Hospital, Australia; Department of Medicine (Royal Melbourne Hospital), University of Melbourne, - - 2014
In patients with renal failure or chronic inflammation, the accumulation of fetuin-A-containing calciprotein particles (CPP) in the extracellular fluid has been implicated in driving inflammatory pathways and extraosseous mineral deposition. We aimed to discover whether CPP are present in the peritoneal dialysis fluid effluent (PDF) of stable peritoneal dialysis (PD) ...
Jiang Honglei H Department of Cardiology, Provincial Hospital of Shandong University, Jinan, Shandong 250021, P.R. - - 2014
The aim of the present study was to investigate whether acylation stimulating protein (ASP) and complement component 3 (C3) are associated with the occurrence and development of coronary heart disease (CHD). The participants of the study were divided into three groups, including the healthy control (n=42), metabolic syndrome (MS, n=56) ...
Zakharov Sergey S Toxicological Information Center, Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech - - 2014
To study the role of serum formate (S-formate) in diagnosing methanol poisoning. A prospective study was undertaken of 38 patients from the Czech methanol mass poisoning in 2012 - median age 51 (interquartile range (IQR) 37-62) years with confirmed methanol poisoning. S-formate was measured enzymatically. The receiver operating characteristics (ROC) ...
Kim Seon Young SY Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, - - 2014
Protein Z (PZ) is an anticoagulant that accelerates the inhibitory effect of PZ-dependent protease inhibitor (ZPI) on coagulation factor Xa. We assessed functional status of PZ system in 158 patients with liver cirrhosis and 59 healthy controls. Plasma PZ and ZPI levels were measured by enzyme immunoassay. Thrombin generation assays ...
Hosseinifar Hani H Department of Andrology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, - - 2014
To find a relationship between absence of annulus and asthenozoospermia in Iranian men. In the present study, semen samples from 100 asthenozoospermic and 20 normozospermic patients were analyzed for sperm concentration and motility. Spermatozoa were immunostained for the two septin subunits Sept4 and Sept7. The absence of the annulus structure ...
Aanaes Kasper K Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark, - - 2014
The paranasal sinuses can be a focus for colonisation of the cystic fibrosis (CF) lungs with pathogens. In the sinuses, bacteria can adapt to the lung environment and enhance their antibiotic resistance, with biofilm formation thought to be the most important adaptive mechanism, causing recalcitrant disease. The presence of biofilms ...
Pozdnyakova Olga - - 2014
Abstract We characterized recently identified event clusters in systemic mastocytosis (SM) by calculating the coefficient of variation (CV, %) of CD117 and side scatter (SSC), based on the mean fluorescence intensity of mast cells using flow cytometry. Seventy-five samples were from SM patients and 124 samples from patients negative for ...
Saied A A Roger Williams Medical Center, Department of Surgery, Providence, RI/Boston University School of Medicine, Boston, MA, - - 2014
Our phase I Hepatic Immunotherapy for Metastases (HITM) trial tested the safety of chimeric antigen receptor-modified T-cell (CAR-T) hepatic artery infusions (HAI) for unresectable carcinoembryonic antigen (CEA)+ liver metastases (LM). High neutrophil:lymphocyte ratios (NLR) predict poor outcome in cancer patients and we hypothesized that NLR changes would correlate with early ...
Fredholm Simon S Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, - - 2014
Eosinophil granulocytes have been implicated in anticancer immunity but recent data indicate that eosinophils can also promote cancer. Herein, we studied eosinophils in skin lesions from 43 patients with mycosis fungoides (MF). The presence of eosinophils correlated with disease stage: 78% of patients with advanced disease displayed eosinophil infiltration, whereas ...
Ahmadi Farrokhlagha F Department of Nephrology, Imam Khomeni Hospital, Nephrology Research Center, Tehran University of Medical Sciences , Tehran , Iran - - 2014
Abstract Background: Residual renal function (RRF) plays a key role in the follow-up of the patients undergoing chronic ambulatory peritoneal dialysis (CAPD). Available methods for measurement of RRF are cumbersome and rarely used, and alternatively, cystatin C-derived equations have been proposed. Methods: Seventy-six adult CAPD patients were recruited. RRF was ...
Kim Jae-Jung JJ Asan Institute for Life Sciences, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 138-736, - - 2014
Kawasaki disease (KD) is an acute self-limiting form of vasculitis that afflicts infants and children and manifests as fever and signs of mucocutaneous inflammation. Children with KD show various laboratory inflammatory abnormalities, such as elevations in their white blood cell (WBC) count, C-reactive protein (CRP) level, and erythrocyte sedimentation rate ...
Asano Takeshi T Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital, Inzai City, Chiba Prefecture, - - 2014
Background:In acute encephalopathy, deterioration of the condition can be rapid and early intervention is essential to prevent progression of the disease. However, in the acute period, differentiating acute encephalopathy from febrile seizures is difficult. Thus, an early diagnostic marker has been sought to enable early intervention. Proton nuclear magnetic resonance ...
Kondelkova Katerina K Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech - - 2014
Toll-like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T-cell driven immune-mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The ...
Naumnik W W Department of Lung Diseases, Medical University of Bialystok, 14 Zurawia St., 15-540, Bialystok, Poland, - - 2014
Recently, it has been reported that lack of cathepsins prevent the development of lung granulomas in a mouse model of Besnier-Boeck-Schaumann (BBS) disease, sarcoidosis. There is no data about cathepsin V (Cath V) in bronchoalveolar lavage fluid (BALF) in humans. Endostatin is a novel inhibitor of lung epithelial cells. The ...
Peraldo Neia Caterina C Department of Oncology, University of Turin Medical School, IRCCS-Candiolo, Turin, - - 2014
ROS1 rearrangements have been detected in a variety of tumors and are considered as suitable targets of anticancer therapies. We developed a new, quick, specific, and sensitive PCR test to screen for the FIG-ROS1 fusion and applied it to a series of Italian patients with bile duct carcinoma (BTC). Formalin-fixed, ...
Nalin Tatiéle T Post-Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, - - 2014
Uncooked cornstarch (UCCS) is a widely used treatment strategy for patients with hepatic glycogen storage disease (GSD). It has been observed that GSD-patients display different metabolic responses to different cornstarches. The objective was to characterize starch fractions and analyze the digestion of different starches in a dynamic gastrointestinal in vitro ...
McNamara Nancy A NA Francis I. Proctor Foundation, University of California, San Francisco, 513 Parnassus, Box 0412, San Francisco, California, 94143-0412, United States - - 2014
Purpose: Sjögren's syndrome (SS) is a common autoimmune disease that can cause aqueous-deficient dry eye and the aberrant differentiation of ocular mucosal epithelial cells toward a lineage that is pathologically keratinized and skin-like. PAX6 is the master regulator of corneal lineage commitment. Recently, we showed a functional role for PAX6 ...
Vlachos Sotirios S Second Department of Surgery, Medical School, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100, Greece; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, - - 2014
Several studies state that a test of severity early in the course of acute pancreatitis is still needed. In this prospective study, an assay of the biomarkers M30 and M65 as well as of interleukin 17 (IL-17) is investigated. One hundred and fifty patients and 70 controls were evaluated. The ...
Caldwell Julie M JM Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, - - 2014
The definition of eosinophilic gastritis (EG) is currently limited to histologic EG based on the tissue eosinophil count. We aimed to provide additional fundamental information about the molecular, histopathologic, and clinical characteristics of EG. Genome-wide transcript profiles and histologic features of gastric biopsy specimens, as well as blood eosinophil counts, ...
Marsh Anne A Department of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA; Children's Hospital Oakland Research Institute, Oakland, CA, - - 2014
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 2·3-fold higher ...
Li Ying Ying YY Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Aberrant airway epithelial remodeling is one of the cardinal histopathologic features of inflammatory airway diseases, but whether it alters the mucociliary apparatus remains unknown. We sought to investigate the morphologic pattern of motile cilia and ciliogenesis-associated makers in hyperplastic nasal epithelium from nasal polyps (NPs) both in vivo and in vitro. Biopsy ...
Kim Sun Min SM Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of - - 2014
Abstract Objective Acute histologic chorioamnionitis (HCA) is associated with increased risk of perinatal mortality and morbidity. The purpose of this study was to determine the relationship between the intensity of intra-amniotic inflammation (IAI) and the severity of acute HCA in preterm gestation. Methods The relationship between the intensity of IAI ...
Martin Brock A BA Departments of *Pathology †Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition ‡Department of Pediatrics, Lucile Packard Children's Hospital and Stanford University Medical Center, Stanford, - - 2014
Congenital enteropathies are rare disorders with significant clinical consequences; however, definitive diagnosis based on morphologic assessment of duodenal biopsies with routine stains alone is often impossible. To determine the role of immunohistochemistry (IHC) in the evaluation for microvillous inclusion disease, congenital tufting enteropathy (intestinal epithelial dysplasia), and enteroendocrine cell dysgenesis, ...
Hou Shengping S The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Ophthalmology, Chongqing, China Chongqing Eye Institute, Chongqing, - - 2014
Considering the phenotypical consequences and association of C4 copy number variation (CNV) with various autoimmune diseases, we aimed to examine C4 CNVs for 1027 patients with Vogt-Koyanagi-Harada (VKH) syndrome and 2083 controls. C4 CNVs were examined by real-time PCR for 1027 patients with VKH and 2083 controls. Peripheral blood mononuclear ...
Joshi D D Department of Gastroenterology, University College London Hospital, - - 2014
A 64 year-old Caucasian gentleman presented with abnormal liver biochemistry (ALP 212 IU/L, ALT 75 IU/L, GGT 301 IU/L, albumin 38 g/L bilirubin 55 umol/L, INR 1.1). He was asymptomatic with no history of weight loss. He had a history of well controlled ulcerative colitis. Axial imaging and an ERCP ...
Martins Paulo Roberto Juliano PR Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. Electronic address: - - 2014
Changes in weight/height ratio, delayed sexual maturation, hypogonadism and impaired fertility have been demonstrated in sickle cell disease (SCD). This study aimed to evaluate the clinical and laboratory views of the Leydig cells function after stimulation with hCG in adults with sickle cell disease. We studied 15 patients with SCD ...
Ozcan Erkan E Department of Periodontology, Center of Oral Health, Gülhane Military Hospital, Ankara, Turkey, - - 2014
In recent years, adipokines have been reported to play an important role in chronic inflammatory diseases. In this study, our aim was to investigate the salivary levels of visfatin, chemerin, and progranulin and their relationship with periodontal health and disease. A total of 72 patients were included in the study, ...
Mroczko Barbara B Department of Neurodegeneration Diagnostics, Medical University of Białystok, Poland Department of Biochemical Diagnostics, University Hospital in Białystok, - - 2014
Background: The correlations between pathology of neurodegenerative diseases, especially Alzheimer's disease (AD), and concentrations of neuronal calcium sensor proteins, such as visinin-like protein 1 (VILIP-1), in cerebrospinal fluid (CSF) have been discussed in the literature but its utility as biomarker of AD in comparison with mild cognitive impairment (MCI) has ...
Vayá Amparo A Department of Clinical Pathology, Hemorheology and Haemostasis Unit, La Fe University Hospital, Valencia, Spain - - 2014
There is no information about a possible association of red blood cell distribution width (RDW) with cryptogenic stroke (CS). We aimed to analyze the association of RDW with CS. One hundred and sixty-three patients with CS were included along with 186 healthy controls. Fibrinogen, leukocytes, hemoglobin, and erythrocyte indices were ...
Steel Ryan R School of Biological Sciences, Victoria University of Wellington, Wellington, New - - 2014
Propranolol is increasingly used to treat problematic infantile haemangioma (IH), although its molecular mechanisms remain unclear. A key feature of propranolol therapy is the decreased deposition of fibrofatty residuum compared with spontaneously involuting IH. This study investigated the molecular consequences of propranolol treatment for IH in vivo. Immunohistochemical and terminal ...
Gluba-Brzózka Anna - - 2014
Epidemiological studies have shown that chronic kidney disease (CKD) is an important risk factor for atherosclerosis and cardiovascular disease (CAD). The aim of the study was to determine markers of increased risk of CAD and to achieve a better understanding of agents implicated in the process of atherosclerosis in CKD ...
Yang Dong D Department of Otolaryngology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, - - 2014
This study was conducted to determine the concentration of EPCs in patients with ARHL. Twenty patients with ARHL were evaluated. The number of EPCs was analyzed by flow cytometry analysis of peripheral blood CD34(+)/CD133(+) cells. The concentration of circulating EPCs, both for CD34(+)/CD133(+) cells, was significantly lower in ARHL patients ...
Mazzawi Tarek T Section for Gastroenterology, Department of Medicine, Stord Helse‑Fonna Hospital, Stord, - - 2014
The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated by these cells. Furthermore, it has been established that gut endocrine cells interact with the gut lumen contents, ...
Figuères Marie-Lucile ML Department of Pathology, Hôpital Necker, AP-HP, Paris, France - - 2014
Dense deposit disease is characterized by dense deposits in the glomerular and tubular basement membranes. We report 3 cases with long-term follow-up differing in histologic pattern and clinical evolution. Clinical and histologic data were collected between 1976 and 2012. Age at the first manifestations was 6, 11, and 23 years, ...
Moon Myung-Sang MS Department of Orthopedic Surgery and Traumatology, Cheju Halla General Hospital, Jeju, - - 2014
To assess the preoperative nutritional status of patients with various disorders and to provide data for pre- and postoperative patient management plans, particularly in the elderly. There is no published information on age-matched and disease-matched preoperative nutritional/immunologic status for orthopedic patients, especially in the elderly, in Jeju. In total, 331 ...
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