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Matsui Masaru M First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, - - 2014
Systemic reactive AA amyloidosis is a life-threatening complication of chronic inflammatory diseases. Anti-interleukin-6 receptor, tocilizumab (TCZ), has been shown to improve clinical symptoms of patients with AA amyloidosis, accompanied with regression of the amyloid deposition. We report a case of AA amyloidosis evaluated by histology of multiple organs before and ...
Gaowa Saren S 0000-0003-4620-0860 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, - - 2014
This prospective cohort study is to verify the hypothesis that the balance of Th17 and Treg cells frequencies in the peripheral circulation is disturbed in patients with varying degrees of connective tissue diseases-associated pulmonary arterial hypertension (CTD-aPAH) and to prove the influence of Th17/Treg imbalance on prognosis. We detected the ...
Zhang Yaping Y 1. Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, - - 2014
Lung cancer (LC) is the deadliest cancer, with earlier stage patients having a better opportunity of long-term survival. The goal of this study is to screen less-invasive and efficient biomarkers for early detection of non-small cell LC (NSCLC). We performed the simultaneous quantitative detection of six serum unsaturated free fatty ...
Yamakawa Hideaki H Respiratory Medicine, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, - - 2014
A 61-year-old woman being treated with methotrexate (MTX) 8-10 mg/week and prednisolone 2.5 mg/day for rheumatoid arthritis presented with a 1-week history of increasing fever and dry cough. The patient deteriorated with administration of antibiotics. Chest CT scan showed bilateral diffuse ground-glass opacities. Analysis of bronchoalveolar lavage fluid (BALF) revealed marked neutrophilia ...
Messingham Kelly N KN Department of Dermatology, University of Iowa, Iowa City, Iowa, United States of - - 2014
Bullous pemphigoid (BP) is an autoimmune blistering disease mediated by autoantibodies targeting BP180 (type XVII collagen). Patient sera and tissues typically have IgG and IgE autoantibodies and elevated eosinophil numbers. Although the pathogenicity of the IgE autoantibodies is established in BP, their contribution to the disease process is not well ...
Sönmez Derya - - 2014
We aimed to measure small, dense LDL (sdLDL) and lipoprotein-associated phospholipase A2 (Lp-PLA2) concentrations and to evaluate their relationship with other risk factors of atherosclerotic heart disease in dialysis patients. Study group consisted of 30 peritoneal dialysis and 20 hemodialysis patients with 20 healthy control subjects. sdLDL was measured by ...
Nilsson Lennart L Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Department of Cardiology, Linköping University, Linköping, - - 2014
Elevations in soluble markers of inflammation and changes in leukocyte subset distribution are frequently reported in patients with coronary artery disease (CAD). Lately, the neutrophil/lymphocyte ratio has emerged as a potential marker of both CAD severity and cardiovascular prognosis. The aim of the study was to investigate whether neutrophil/lymphocyte ratio ...
Schmidt Jana J Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, - - 2014
Immunological processes in the etiopathogenesis of periodontitis, especially the aggressive form, are not well understood. This study examined clinical as well as systemic immunological and local microbiological features in healthy controls and patients with different forms of periodontitis. 14 healthy subjects, 15 patients diagnosed with aggressive periodontitis, and 11 patients ...
Yelken Berna - - 2014
There is increasing evidence that long-term peritoneal dialysis (PD) is associated with structural changes in the peritoneal membrane. Inhibition of the renin-angiotensin system has been demonstrated to lessen peritoneal injury and to slow the decline in residual renal function. Whether spironolactone affects residual renal function in addition to the peritoneal ...
Gale G G Department of Oral Medicine and Pathology, Institute of Odontology The Sahlgrenska Academy, University of Gothenburg, Box 450, SE405 30 Gothenburg, Sweden, - - 2014
The aim of this investigation was to characterise and compare the inflammatory infiltrates in patients with orofacial granulomatosis solely (OFG-S) and OFG with coexisting Crohn's disease (OFG+CD). Biopsy specimens with granulomas were obtained from patients with OFG-S (n=11) and OFG+CD (n=11) and immunostained with antibodies against CD1a, CD3, CD4, CD8, ...
Vaidya Seema - - 2013
Hereditary Ectodermal Dysplasia is an inherited disorder commonly involving skin, teeth, hair, and nails. We have observed ectodermal dysplasia (EDs) in 11 individuals over two generations in one family. Smooth, dry, thin skin was seen in most affected individuals. All had fine, slow-growing scalp hair and body hair and some ...
Faller Bernadette - - 2013
BACKGROUND: Reasons underlying dialysis decision-making in Octogenarians and Nonagenarians have not been further explored in prospective studies. METHODS: This regional, multicentre, non-interventional and prospective study was aimed to describe characteristics and quality of life (QoL) of elderly (>=80 years of age) with advanced chronic kidney disease (stage 3b-5 CKD) newly ...
Sulli Alberto - - 2013
OBJECTIVE: This study evaluates possible correlations between the pattern of antinuclear antibodies (ANA) on indirect immunofluorescence (IIF) testing and nailfold microangiopathy stage (early, active, and late stage) in systemic sclerosis (SSc). Patients with SSc were followed prospectively to monitor progression of microvascular damage. METHODS: The ANA pattern on IIF was ...
Skoog Katrina K University of Florida School of Medicine, Gainesville, FL, - - 2013
Polycythemia vera is defined as a chronic myeloproliferative disorder characterized by increased red blood cell count. There have been no reports on mesenteric thrombosis resulting from iatrogenic polycythemia. We present a patient with a history of non-small cell lung cancer undergoing maintenance oral chemotherapy on tarceva and adjunctive use of ...
Carneiro Jamille Nascimento - - 2012
Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. Its prevalence in patients with psoriasis varies from 7 to 42% but its exact prevalence is unknown. Considering the lack of national data related to its diagnosis in patients with psoriasis, this study aims to describe the clinical, laboratorial and radiological ...
Tanouchi Tetsu T Department of Orthopedic Surgery, Gunma Spine Center (Harunaso Hospital), 878-1 Kamitoyooka, Takasaki, Gunma 370-0871, Japan. - - 2012
Mutilating-type rheumatoid arthritis, the most aggressive type of rheumatoid arthritis, is frequently associated with destructive cervical involvement, both at the high-cervical and subaxial levels, causing significant neurological deficit, and their natural course of the disease and the survival are discouraging. For such cases, we have been actively performing occipito-thoracic fusion ...
Kretapirom K K Department of Oral and Maxillofacial Radiology, Tokyo Medical and Dental University, Tokyo, - - 2013
The aim of this study was to investigate characteristic MRI findings of rheumatoid arthritis (RA) in the temporomandibular joints (TMJs). 61 patients (122 TMJs) with RA in the TMJ and 50 patients (100 TMJs) with temporomandibular disorder (TMD) were included in this study. MR images of these patients were assessed ...
Shibuya Naohiro - - 2012
Insertional Achilles tendinosis is a condition where a patient complains of isolated pain at the Achilles tendon insertion site due to intratendinous degeneration. It has been suggested that this condition is associated with cavus foot deformity. However, to our knowledge, there is no study that has confirmed this observation. We ...
Kojima Kentaro - - 2012
PURPOSE: Sarcoidosis is an idiopathic inflammatory disorder involving multiple organs, and ocular manifestation (represented by granulomatous uveitis) is one of the common features. A well-known immunologic feature in sarcoidosis is an increased CD4+ helper T-cell type 1 lymphocyte subset in bronchoalveolar lavage (BAL) fluid. The current study investigated the vitreous ...
Girolami Antonio - - 2012
Immunological thrombocytopenias, as other forms of thrombocytopenia, are associated with bleeding. Occasionally, these patients manifest thrombotic events. A total of at least 29 patients were reported to have had either arterial (20 cases) or venous (9 cases) thrombosis while platelet count was less than 50 × 10(3)/μL. The most frequent ...
Wilczynska Maria M - - 2012
The presence of bronchiectasis in patients with rheumatoid arthritis has been recognised for many decades, but despite this, little research has been undertaken in this area. It is important to recognise that bronchiectasis co-existent with rheumatoid arthritis differs from the other types of bronchiectasis. The purpose of this descriptive review ...
Oka S - - 2012
A novel HLA allele, HLA-DQB1*06:51, was identified in a Japanese rheumatoid arthritis patient.
Dhaliwal Sandeep - - 2012
Septic arthritis is an orthopedic emergency that can lead to significant morbidity and mortality. Polyarticular involvement is a relatively rare phenomenon occurring primarily in high-risk patients. In this article, we report the rare case of a patient with rheumatoid arthritis presenting with an acute episode of septic arthritis involving most ...
Liimatainen Suvi - - 2012
INTRODUCTION: Dysfunction of immunoglobulins (Igs) has been detected in association with antiepileptic drugs (AEDs) and in newly diagnosed epilepsy patients. The aim of this study was to evaluate the effect of clinical features and the current or past use of AEDs on serum Ig concentrations in a well-examined group of ...
Hueskes Berdine A A - - 2012
AIMS: Gouty arthritis is a frequent and disabling complication in heart failure patients. This study aimed to investigate which factors are associated with the occurrence of gouty arthritis in these patients. METHODS AND RESULTS: A case-control study was performed in heart failure patients (February 2007 to October 2009). Cases were ...
Ng Teik-Ying - - 2012
OBJECTIVE: Nasal obstruction is one of the most common sensation complaints of nasal disease in clinical practice. It is a subjective sensation of nasal airflow. Objective assessment of nasal patency and nasal physiology includes the use of rhinomanometry and acoustic rhinometry. The perception of nasal obstruction changes as the alternating ...
Nishimura Wester Eidi - - 2012
OBJECTIVE: To evaluate the frequency of HLA classes I and II and their association with the cutaneous manifestation of rheumatoid vasculitis (RV) in Brazilian patients. PATIENTS AND METHODS: During one year we selected 130 patients with rheumatoid arthritis (RA) classified according to the American College of Rheumatology, 1987. All patients ...
Fujimoto Chisato - - 2012
The aim of this study was to reveal the clinical characteristics of dissociated bilateral vestibulopathy (BV) affecting the superior vestibular nerve system on one side and the inferior vestibular nerve system on the other side. It is probable that BV does not always show bilateral deficits of the same vestibular ...
Song Jae-Jin - - 2012
Abstract Conclusions: Enlarged vestibular aqueduct (EVA) may precipitate secondary benign paroxysmal positional vertigo (BPPV), especially in pediatric populations, as well as paretic dysfunction of the vestibular end organ. Objectives: EVA is characterized by the early onset of sudden or progressive sensorineural hearing loss with or without vestibular dysfunction. However, vestibular ...
Monteiro Silvia Roberta Gesteira SR Graduate Program in Human Communication Disorders - Federal University of São Paulo - Paulista School of Medicine, SP, Brazil. - - 2012
Posturography has been used in the evaluation of patients with vestibular disorders. To evaluate balance control with the Balance Rehabilitation Unit (BRU™) posturography in patients with Benign Paroxysmal Positional Vertigo. Prospective case-control. A cross-sectional controlled study was carried out in 45 patients with BPPV, and a homogeneous control group consisting ...
Love Thorvardur Jon - - 2012
OBJECTIVE: To measure the associations between subtypes of nail changes and psoriatic arthritis (PsA) among patients with psoriasis. METHODS: Patients age 18 years and older with active psoriasis were examined for skin and nail changes and asked if they had been diagnosed with PsA. Patients with arthritis were invited for ...
Goshayeshi Ladan - - 2012
Rheumatoid arthritis (RA) is the most common autoimmune arthritis. The impact of chronic inflammation on atherosclerosis and insulin resistance has been observed in several autoimmune diseases. On the other hand, metabolic syndrome (MetS); a cluster of traditional risk factors for atherosclerosis and diabetes seems to be prevalent in RA patients. ...
van der Helm-van Mil Annette H M - - 2012
Rheumatoid arthritis (RA) is diagnosed based on phenotypic characteristics. The 2010 ACR/EULAR criteria were derived with the aim of classifying RA earlier in the disease course than the 1987 ACR criteria. When reviewing thus far published validation studies, it is clear that the 2010 criteria can be fulfilled earlier in ...
Jung Jae Yun - - 2012
OBJECTIVE: The objective of this study was to examine whether any clinical difference existed with respect to the characteristics of dizziness in vestibular neuritis (VN) and sudden sensorineural hearing loss with vertigo (SHLV). STUDY DESIGN: Retrospective review. SETTING: Tertiary referral center. PATIENTS: Included in this study were 22 SHLV patients ...
Modabbernia Amirhossein - - 2012
Our aim was to quantitatively evaluate the role of internal jugular venous reflux (IJVR) in transient global amnesia (TGA). Meta-analysis of case-control studies was conducted using Medline, Current contents connect, ISI Web of Knowledge, Biological abstracts and Scopus, plus citations of selected studies. We performed sensitivity and subgroup analyses to ...
Stamenković Bojana - - 2012
Anti-citrullinated peptides antibodies (ACPA) are present in 80% of sera of rheumatoid arthritis (RA) patients with high specificity for diagnosis and prediction for the development of early erosive arthritis. A few studies have reported a low frequency ACPA in systemic sclerosis (SSc) patients with the presence of arthritis. The aim ...
Jeschke Udo - - 2012
Aim: Mucin 1 (MUC1) is a high molecular weight transmembrane glycoprotein with unique properties which is used as a tumour marker in sera of ovarian cancer patients. The common test kit for the cancer antigen 15-3 (CA15-3) is not sufficient for the discrimination between sera from healthy individuals and sera ...
Lambova Sevdalina Nikolova - - 2012
In rheumatology, specific is the capillaroscopic pattern in systemic sclerosis (SSc), the so-called "scleroderma type". Capillaroscopic pattern in systemic lupus erythematosus (SLE) is less specific and includes a wide range of microvascular changes-"SLE-type" capillaroscopic pattern, non-specific findings and in a small percentage "scleroderma-like" pattern. The latter finding is currently associated ...
Egawa Hiroto H Departments of Surgery Diagnostic Pathology, Kyoto University Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University Division of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto, - - 2012
  We hypothesized that non-inflammatory central sinusoidal fibrosis (NICSF) is a sign of inadequate immunosuppression in children after living-donor liver transplantation.   In study 1, liver biopsy specimens of 158 patients who had undergone liver transplantation 10 years before or earlier were examined to study the relationship between NICSF and tacrolimus ...
Mossberg N - - 2012
OBJECTIVES: To describe a population-based material of patients with recurrent Guillain-Barré syndrome (RGBS), examine the long time course, and search for factors predisposing to recurrence. MATERIALS AND METHODS: We performed a follow-up study of the neurology and neurophysiology and a systematic study of the acute microbial serology of patients with ...
van den Berg Rosaline - - 2012
OBJECTIVES: The performance of spondyloarthritis (SpA) classification criteria is not well-established in general early arthritis cohorts. Therefore, the authors tested their performance in the Leiden Early Arthritis Clinic (EAC) cohort and assessed whether these criteria can assist rheumatologists in diagnosing patients.METHODS: The authors identified all SpA and psoriatic arthritis (PsA) ...
Lammers A J Jolanda - - 2012
Asplenic patients are at risk for pneumococcal sepsis. Patients with hyposplenic function, such as associated with sickle cell disease (SCD), are also at risk. However, tests to assess splenic function are either unavailable or lacking standardization. The aim of this study was to compare different methods for determining splenic function. ...
Lee Yeo Jin - - 2012
Although biphasic head-shaking nystagmus (HSN) is a basic response to head shaking in patients with unilateral vestibular loss, monophasic HSN is commonly seen in patients with dizziness of undetermined etiology. Since the clinical significance of HSN remains unclear, we sought to characterize different types of HSN in patients with vestibular ...
Samson Maxime - - 2012
OBJECTIVE: From an immunological standpoint, the mechanisms by which Tocilizumab (TCZ), a humanized anti-interleukin-6 (IL-6) receptor antibody, improves Rheumatoid Arthritis (RA) patients are still not fully understood. In vitro studies and results from mouse models have emphasized the critical role of IL-6 in Th17 differentiation. Th17 lymphocytes have been demonstrated ...
McDonnell Matthew - - 2012
The majority of patients with rheumatoid arthritis involving the cervical spine can be managed non-operatively. These patients should be monitored closely by the treating physician for the development of neurologic symptoms or subluxation on radiographs. Non-surgical treatment in the majority of patients has a definite role. Several studies now suggest ...
Cho Gye Song GS Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South - - 2012
The objective of the present study was to investigate the relationship between the subjective sensation of nasal obstruction and the corresponding cross-sectional area for nasal airflow in patients with a deviated septum. Seventy-one patients with a diagnosis of unilateral nasal obstruction due to a deviated nasal septum were evaluated by ...
Al-Herz Waleed W Department of Pediatrics, Faculty of Medicine, Kuwait University, and Allergy & Clinical Immunology Unit, Pediatric Department, Al-Sabah Hospital, Safat, Kuwait. - - 2012
Deficiency of dedicator of cytokinesis 8 (DOCK8) is a newly described combined primary immunodeficiency disease. It was found to account for 15% of combined immune deficiency cases in the National Primary Immunodeficiency Disorders Registry in Kuwait, a country with high prevalence of consanguinity. We present the clinical, immunologic and molecular ...
Karaca Neslihan Edeer - - 2012
Mutations of the CD40 gene have been found in patients with autosomal recessive hyper-immunoglobulin M (HIGM) syndrome type 3. Five patients from 4 unrelated families with CD40 mutation have been reported so far. Clinical manifestations include recurrent sinopulmonary infections, Pneumocystis carinii pneumonia, and Cryptosporidium parvum infection. Affected patients typically have ...
Gu Hong-Xiang - - 2012
BACKGROUND AND OBJECTIVES: Microscopic colitis includes lymphocytic colitis and collagenous colitis. The entity is considered as an important cause for unknown chronic diarrhea, but rarely reported in China before. This study aimed to determine the prevalence of microscopic colitis in patients with chronic diarrhea and normal colonoscopy findings in Southern ...
Yeh Fang-Ching - - 2012
BACKGROUND: Klebsiella pneumoniae liver abscess (KLA) is an emerging infectious disease caused by the virulent K pneumoniae strains of capsular serotype K1 and commonly associated with diabetes mellitus. Recurrent KLA is rarely reported and the mechanism of recurrence is uncertain. In this study we evaluated both phagocytosis by neutrophils and ...
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