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Caldwell Julie M JM Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, - - 2014
The definition of eosinophilic gastritis (EG) is currently limited to histologic EG based on the tissue eosinophil count. We aimed to provide additional fundamental information about the molecular, histopathologic, and clinical characteristics of EG. Genome-wide transcript profiles and histologic features of gastric biopsy specimens, as well as blood eosinophil counts, ...
Vlachos Sotirios S Second Department of Surgery, Medical School, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100, Greece; Postgraduate Program in Hepatobiliary/Pancreatic Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, - - 2014
Several studies state that a test of severity early in the course of acute pancreatitis is still needed. In this prospective study, an assay of the biomarkers M30 and M65 as well as of interleukin 17 (IL-17) is investigated. One hundred and fifty patients and 70 controls were evaluated. The ...
Marsh Anne A Department of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA; Children's Hospital Oakland Research Institute, Oakland, CA, - - 2014
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 2·3-fold higher ...
Li Ying Ying YY Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Aberrant airway epithelial remodeling is one of the cardinal histopathologic features of inflammatory airway diseases, but whether it alters the mucociliary apparatus remains unknown. We sought to investigate the morphologic pattern of motile cilia and ciliogenesis-associated makers in hyperplastic nasal epithelium from nasal polyps (NPs) both in vivo and in vitro. Biopsy ...
Kim Sun Min SM Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of - - 2014
Abstract Objective Acute histologic chorioamnionitis (HCA) is associated with increased risk of perinatal mortality and morbidity. The purpose of this study was to determine the relationship between the intensity of intra-amniotic inflammation (IAI) and the severity of acute HCA in preterm gestation. Methods The relationship between the intensity of IAI ...
Martin Brock A BA Departments of *Pathology †Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition ‡Department of Pediatrics, Lucile Packard Children's Hospital and Stanford University Medical Center, Stanford, - - 2014
Congenital enteropathies are rare disorders with significant clinical consequences; however, definitive diagnosis based on morphologic assessment of duodenal biopsies with routine stains alone is often impossible. To determine the role of immunohistochemistry (IHC) in the evaluation for microvillous inclusion disease, congenital tufting enteropathy (intestinal epithelial dysplasia), and enteroendocrine cell dysgenesis, ...
Hou Shengping S The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chongqing Key Laboratory of Ophthalmology, Chongqing, China Chongqing Eye Institute, Chongqing, - - 2014
Considering the phenotypical consequences and association of C4 copy number variation (CNV) with various autoimmune diseases, we aimed to examine C4 CNVs for 1027 patients with Vogt-Koyanagi-Harada (VKH) syndrome and 2083 controls. C4 CNVs were examined by real-time PCR for 1027 patients with VKH and 2083 controls. Peripheral blood mononuclear ...
Joshi D D Department of Gastroenterology, University College London Hospital, - - 2014
A 64 year-old Caucasian gentleman presented with abnormal liver biochemistry (ALP 212 IU/L, ALT 75 IU/L, GGT 301 IU/L, albumin 38 g/L bilirubin 55 umol/L, INR 1.1). He was asymptomatic with no history of weight loss. He had a history of well controlled ulcerative colitis. Axial imaging and an ERCP ...
Martins Paulo Roberto Juliano PR Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. Electronic address: - - 2014
Changes in weight/height ratio, delayed sexual maturation, hypogonadism and impaired fertility have been demonstrated in sickle cell disease (SCD). This study aimed to evaluate the clinical and laboratory views of the Leydig cells function after stimulation with hCG in adults with sickle cell disease. We studied 15 patients with SCD ...
Ozcan Erkan E Department of Periodontology, Center of Oral Health, Gülhane Military Hospital, Ankara, Turkey, - - 2014
In recent years, adipokines have been reported to play an important role in chronic inflammatory diseases. In this study, our aim was to investigate the salivary levels of visfatin, chemerin, and progranulin and their relationship with periodontal health and disease. A total of 72 patients were included in the study, ...
Mroczko Barbara B Department of Neurodegeneration Diagnostics, Medical University of Białystok, Poland Department of Biochemical Diagnostics, University Hospital in Białystok, - - 2014
Background: The correlations between pathology of neurodegenerative diseases, especially Alzheimer's disease (AD), and concentrations of neuronal calcium sensor proteins, such as visinin-like protein 1 (VILIP-1), in cerebrospinal fluid (CSF) have been discussed in the literature but its utility as biomarker of AD in comparison with mild cognitive impairment (MCI) has ...
Vayá Amparo A Department of Clinical Pathology, Hemorheology and Haemostasis Unit, La Fe University Hospital, Valencia, Spain - - 2014
There is no information about a possible association of red blood cell distribution width (RDW) with cryptogenic stroke (CS). We aimed to analyze the association of RDW with CS. One hundred and sixty-three patients with CS were included along with 186 healthy controls. Fibrinogen, leukocytes, hemoglobin, and erythrocyte indices were ...
Steel Ryan R School of Biological Sciences, Victoria University of Wellington, Wellington, New - - 2014
Propranolol is increasingly used to treat problematic infantile haemangioma (IH), although its molecular mechanisms remain unclear. A key feature of propranolol therapy is the decreased deposition of fibrofatty residuum compared with spontaneously involuting IH. This study investigated the molecular consequences of propranolol treatment for IH in vivo. Immunohistochemical and terminal ...
Gluba-Brzózka Anna - - 2014
Epidemiological studies have shown that chronic kidney disease (CKD) is an important risk factor for atherosclerosis and cardiovascular disease (CAD). The aim of the study was to determine markers of increased risk of CAD and to achieve a better understanding of agents implicated in the process of atherosclerosis in CKD ...
Yang Dong D Department of Otolaryngology, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, - - 2014
This study was conducted to determine the concentration of EPCs in patients with ARHL. Twenty patients with ARHL were evaluated. The number of EPCs was analyzed by flow cytometry analysis of peripheral blood CD34(+)/CD133(+) cells. The concentration of circulating EPCs, both for CD34(+)/CD133(+) cells, was significantly lower in ARHL patients ...
Mazzawi Tarek T Section for Gastroenterology, Department of Medicine, Stord Helse‑Fonna Hospital, Stord, - - 2014
The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated by these cells. Furthermore, it has been established that gut endocrine cells interact with the gut lumen contents, ...
Figuères Marie-Lucile ML Department of Pathology, Hôpital Necker, AP-HP, Paris, France - - 2014
Dense deposit disease is characterized by dense deposits in the glomerular and tubular basement membranes. We report 3 cases with long-term follow-up differing in histologic pattern and clinical evolution. Clinical and histologic data were collected between 1976 and 2012. Age at the first manifestations was 6, 11, and 23 years, ...
Moon Myung-Sang MS Department of Orthopedic Surgery and Traumatology, Cheju Halla General Hospital, Jeju, - - 2014
To assess the preoperative nutritional status of patients with various disorders and to provide data for pre- and postoperative patient management plans, particularly in the elderly. There is no published information on age-matched and disease-matched preoperative nutritional/immunologic status for orthopedic patients, especially in the elderly, in Jeju. In total, 331 ...
de Carvalho Fraga Carlos Alberto CA Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, - - 2014
The present study aimed to compare levels of VEGFR2 and MMP-9 among control, epithelial dysplasia (ED) and oral squamous cell carcinoma (OSCC) groups. We analyzed 48 patients with oral leukoplakia (OL), 20 patients with OSCC and 21 patients without OL and OSCC. Immunohistochemistry of VEGFR2 and MMP9 were performed and ...
Ramos Laura L Department of Endocrinology, University Hospital "Marques de Valdecilla", University of Cantabria, 39008, Santander, Cantabria, Spain, - - 2014
Ectopic calcifications and even bone formation have been linked to GNAS gene mutations. A 51-year-old Caucasian female had been diagnosed of pseudo-pseudohypoparathyroidism (PPHP) in 1989. She has always had normal serum parathyroid hormone, calcium, and phosphorus levels. A non-contrast computed tomography of the head was done in 2013 and it ...
Kumar N S Satish - - 2014
Bio-impedance is the measure of impedance of the body. Impedance consists of resistance and reactance. Phase angle (PA) is the tan value of the ratio of reactance versus resistance. PA depends on cell membrane integrity and on body cell mass. Earlier studies have shown a correlation between PA values and ...
Rodríguez-Leyva Ildefonso I Neurology Department, Hospital Central "Dr. Ignacio Morones Prieto", Universidad Autónoma de San Luis Potosí San Luis Potosí, - - 2014
The presence in the brain of α-synuclein containing Lewy neurites, or bodies, is the histological hallmark of Parkinson's disease (PD). The discovery of α-synuclein aggregates in nerve endings of the heart, digestive tract, and skin has lent support to the concept of PD as a systemic disease. Our goals were, ...
Krul Sébastien P J SP Heart Center, Department of Experimental Cardiology, Cardiology and Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
In patients with atrial fibrillation (AF), the autonomic nervous system is supposed to play an role in triggering AF; however, little is known of the effect on atrial conduction characteristics. The purpose of this study was to study the effect of ganglionic plexus (GP) stimulation during sinus rhythm on atrial ...
Abdel Salam Ekram - - 2014
The presence of non-progressive cognitive impairment is recognized as a common feature in a substantial proportion of patients with Duchenne muscular dystrophy (DMD). Concurrently, the amyloid beta peptide (Abeta42) protein has been associated with changes in memory and cognitive functions. Also, it has been shown that different subtypes of neural ...
Van Vugt Floris T FT Institute of Music Physiology and Musicians' Medicine, University of Music, Drama, and Media Hanover Hanover, Germany ; Lyon Neuroscience Research Center, CNRS-UMR 5292, INSERM U1028, University Claude Bernard Lyon-1 Lyon, - - 2014
Music-supported therapy has been shown to be an effective tool for rehabilitation of motor deficits after stroke. A unique feature of music performance is that it is inherently social: music can be played together in synchrony. The present study explored the potential of synchronized music playing during therapy, asking whether ...
Ma Jian-Da JD Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yan Jiang West Road, Guangzhou 510120, - - 2014
Objective. To explore the correlation between matrix metalloproteinase- (MMP-) 3 and histological synovitis in rheumatoid arthritis (RA). Methods. Serum MMP-3 of 62 patients with active RA was detected by ELISA. Serial synovial tissue sections from all RA patients, 13 osteoarthritis, and 10 orthopedic arthropathies patients were stained with hematoxylin and ...
Ohara Minami M Department of Biopharmaceutics, Meiji Pharmaceutical University, Tokyo, - - 2014
To clarify pharmacokinetic-pharmacodynamic (PK-PD) factors associated with the over-anticoagulation response in Asians during warfarin induction therapy, population PK-PD analyses were conducted in an attempt to predict the time-courses of the plasma S-warfarin concentration, Cp(S), and coagulation and anti-coagulation (INR) responses. In 99 Chinese patients we analyzed the relationships between dose ...
Shahali Y Y Armand Trousseau Hospital, Biochemistry and Molecular Biology D epartment, Allergy & Environment Group, Paris, - - 2014
Cypress pollen represents the primary cause of respiratory allergies in Mediterranean areas. Patients allergic to Cupressus sempervirens pollen (Cups) (CPA) can be discriminated on the basis of the immunoglobulin E (IgE) binding to a basic 14 kDa protein (BP14) or to high-molecular-weight (HMW) glycoproteins only. Specific IgE repertoires of two ...
Najafian Bita B Department of Pediatrics, Islamic Azad University, Pharmaceutical Science Branch, Tehran, - - 2014
Chronic bronchiolitis is the most important problems of chemical victims of mustard gas. Diverse studies suggest that substance P (SP) as a member of tachykinin neuropeptides, has a significant role in the neurogenic inflammation processes of the airways and lungs. We aimed to determine the serum level of SP in ...
Saito Ryoko R Department of Pathology, Tohoku University School of - - 2014
Targeted anticancer therapies have been developed to interfere with specific target molecules including those of downstream pathways required for tumor growth and progression. Mammalian target of rapamycin (mTOR) has been considered as one of the target molecules of cancer growth, and its inhibitors have been reported to exert an anticancer ...
Matsui Masaru M First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, - - 2014
Systemic reactive AA amyloidosis is a life-threatening complication of chronic inflammatory diseases. Anti-interleukin-6 receptor, tocilizumab (TCZ), has been shown to improve clinical symptoms of patients with AA amyloidosis, accompanied with regression of the amyloid deposition. We report a case of AA amyloidosis evaluated by histology of multiple organs before and ...
Gaowa Saren S 0000-0003-4620-0860 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, - - 2014
This prospective cohort study is to verify the hypothesis that the balance of Th17 and Treg cells frequencies in the peripheral circulation is disturbed in patients with varying degrees of connective tissue diseases-associated pulmonary arterial hypertension (CTD-aPAH) and to prove the influence of Th17/Treg imbalance on prognosis. We detected the ...
Zhang Yaping Y 1. Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, - - 2014
Lung cancer (LC) is the deadliest cancer, with earlier stage patients having a better opportunity of long-term survival. The goal of this study is to screen less-invasive and efficient biomarkers for early detection of non-small cell LC (NSCLC). We performed the simultaneous quantitative detection of six serum unsaturated free fatty ...
Yamakawa Hideaki H Respiratory Medicine, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, - - 2014
A 61-year-old woman being treated with methotrexate (MTX) 8-10 mg/week and prednisolone 2.5 mg/day for rheumatoid arthritis presented with a 1-week history of increasing fever and dry cough. The patient deteriorated with administration of antibiotics. Chest CT scan showed bilateral diffuse ground-glass opacities. Analysis of bronchoalveolar lavage fluid (BALF) revealed marked neutrophilia ...
Messingham Kelly N KN Department of Dermatology, University of Iowa, Iowa City, Iowa, United States of - - 2014
Bullous pemphigoid (BP) is an autoimmune blistering disease mediated by autoantibodies targeting BP180 (type XVII collagen). Patient sera and tissues typically have IgG and IgE autoantibodies and elevated eosinophil numbers. Although the pathogenicity of the IgE autoantibodies is established in BP, their contribution to the disease process is not well ...
Sönmez Derya - - 2014
We aimed to measure small, dense LDL (sdLDL) and lipoprotein-associated phospholipase A2 (Lp-PLA2) concentrations and to evaluate their relationship with other risk factors of atherosclerotic heart disease in dialysis patients. Study group consisted of 30 peritoneal dialysis and 20 hemodialysis patients with 20 healthy control subjects. sdLDL was measured by ...
Nilsson Lennart L Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Department of Cardiology, Linköping University, Linköping, - - 2014
Elevations in soluble markers of inflammation and changes in leukocyte subset distribution are frequently reported in patients with coronary artery disease (CAD). Lately, the neutrophil/lymphocyte ratio has emerged as a potential marker of both CAD severity and cardiovascular prognosis. The aim of the study was to investigate whether neutrophil/lymphocyte ratio ...
Schmidt Jana J Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, - - 2014
Immunological processes in the etiopathogenesis of periodontitis, especially the aggressive form, are not well understood. This study examined clinical as well as systemic immunological and local microbiological features in healthy controls and patients with different forms of periodontitis. 14 healthy subjects, 15 patients diagnosed with aggressive periodontitis, and 11 patients ...
Yelken Berna - - 2014
There is increasing evidence that long-term peritoneal dialysis (PD) is associated with structural changes in the peritoneal membrane. Inhibition of the renin-angiotensin system has been demonstrated to lessen peritoneal injury and to slow the decline in residual renal function. Whether spironolactone affects residual renal function in addition to the peritoneal ...
Gale G G Department of Oral Medicine and Pathology, Institute of Odontology The Sahlgrenska Academy, University of Gothenburg, Box 450, SE405 30 Gothenburg, Sweden, - - 2014
The aim of this investigation was to characterise and compare the inflammatory infiltrates in patients with orofacial granulomatosis solely (OFG-S) and OFG with coexisting Crohn's disease (OFG+CD). Biopsy specimens with granulomas were obtained from patients with OFG-S (n=11) and OFG+CD (n=11) and immunostained with antibodies against CD1a, CD3, CD4, CD8, ...
Yang Juan J Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry, Department of Genetics and Molecular Biology, Medical School of Xi'an Jiaotong University, Xi'an, - - 2014
To investigate discriminating protein patterns and serum biomarkers between clear cell renal cell carcinoma (ccRCC) patients and healthy controls, as well as between paired pre- and post-operative ccRCC patients. We used magnetic bead-based separation followed by matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) to identify patients with ...
Manoussakis Menelaos N MN Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece; Hellenic Pasteur Institute, Athens, - - 2014
Deficient efferocytosis (i.e. phagocytic clearance of apoptotic cells) has been frequently reported in systemic lupus erythematosus (SLE). Todate, patients with primary Sjögren's syndrome (SS) have not been assessed for phagocytosis of apoptotic cells (ApoCell-phagocytosis) and of particulate targets (microbeads, MB-phagocytosis). ApoCell-phagocytosis and MB-phagocytosis were comparatively assessed by flow cytometry in ...
Thawani Jayesh P JP Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, 3 Silverstein Building, 3400 Spruce Street, Philadelphia PA 19104, - - 2014
Examining the pathologic progression of a pituitary adenoma from the point of a prepubescent child to an adult with gigantism affords us an opportunity to consider why patients may develop secretory or functioning tumors and raises questions about whether therapeutic interventions and surveillance strategies could be made to avoid irreversible ...
Sun Yongqiang Y Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical - - 2014
Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease that can cause a series of complications, including cirrhosis, liver failure and hepatocellular carcinoma. Interleukin-33 (IL-33) is expressed in various non-hematopoietic cells and a certain population of immune cells, and exerts its biological effects by binding to the specific receptor, ...
Pulte E Dianne ED Cardeza Foundation for Hematologic Research and Division of Hematology, Thomas Jefferson University , Philadelphia, Pennsylvania , - - 2014
Abstract Previous studies have suggested that erythropoietin (Epo) levels may be inappropriately low in patients with sickle cell disease compared to the extent of the related anemia they demonstrate. Here, we evaluate Epo level vs. renal function, oxygenation, and markers of inflammation for patients treated for sickle cell disease at ...
Thomaidis Thomas T I. Medizinische Klinik der Universitätsmedizin Mainz, Johannes Gutenberg Universität Mainz, Mainz, - - 2014
Malignant ascites is a frequent complication in gastrointestinal malignancy and is unresponsive to systemic therapies. Therapeutic options are limited, and repeated paracentesis is associated with increased loss of fluids and proteins, and impaired quality of life. The bi-specific trifunctional antibody catumaxomab has been approved for the treatment of refractory ascites. ...
Liu Yingzhao Y Department of Laboratory Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China. - - 2014
Hashimoto's thyroiditis (HT) is an organ-specific immune disease characterized by the presence of lymphocytic infiltration and serum autoantibodies. Previous studies have confirmed the critical role of Th17 cells in the pathopoiesis of HT patients. Additionally, regulatory T cells (Treg) display a dysregulatory function in autoimmune disease. The purpose of this ...
Vaidya Seema - - 2013
Hereditary Ectodermal Dysplasia is an inherited disorder commonly involving skin, teeth, hair, and nails. We have observed ectodermal dysplasia (EDs) in 11 individuals over two generations in one family. Smooth, dry, thin skin was seen in most affected individuals. All had fine, slow-growing scalp hair and body hair and some ...
Faller Bernadette - - 2013
BACKGROUND: Reasons underlying dialysis decision-making in Octogenarians and Nonagenarians have not been further explored in prospective studies. METHODS: This regional, multicentre, non-interventional and prospective study was aimed to describe characteristics and quality of life (QoL) of elderly (>=80 years of age) with advanced chronic kidney disease (stage 3b-5 CKD) newly ...
Sulli Alberto - - 2013
OBJECTIVE: This study evaluates possible correlations between the pattern of antinuclear antibodies (ANA) on indirect immunofluorescence (IIF) testing and nailfold microangiopathy stage (early, active, and late stage) in systemic sclerosis (SSc). Patients with SSc were followed prospectively to monitor progression of microvascular damage. METHODS: The ANA pattern on IIF was ...
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