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Winder Klemens K Department of Neurology, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, - - 2014
Objective: To determine associations between ischemic stroke sites and post stroke hyperglycemia (PSH). Methods: Non-diabetic patients with first-ever ischemic stroke confirmed by imaging were prospectively included. Blood glucose level (BGL), National Institute of Health Stroke Scale (NIHSS) score and clinical parameters were assessed on admission. BGL was dichotomized for elevated ...
Morillas Pedro P Servicio de Cardiología, Hospital General Universitario de Elche, Elche, Alicante, Spain. Electronic address: - - 2014
The CHADS2 score is a proven, essential tool for estimating cardioembolic risk (mainly stroke) in patients with nonvalvular atrial fibrillation, with the purpose of determining the indication for anticoagulant therapy. In this study we analyzed the use of CHADS2 in hypertensive patients without known atrial fibrillation in a Mediterranean population. ...
Rodríguez-Sanz Ana A Department of Neurology and Stroke Center - - 2014
Abstract Background: Our goal was to analyze the association of the level of antiphospholipid antibodies (aPLs) with stroke severity and outcome in patients with antiphospholipid syndrome (APS). Methods: Observational study included consecutive patients with ischemic stroke younger than 55 years (2007-2012). We analyzed serum levels of aPLs, including anticardiolipin (aCL) ...
Bonaca Marc P MP TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: - - 2014
Vorapaxar, a novel antiplatelet therapy, reduces thrombotic events in patients with a history of myocardial infarction (MI) or peripheral artery disease (PAD); however, because of an increased risk of intracranial hemorrhage, it is contraindicated in patients with a history of stroke. The aim of this study was to investigate the ...
Johansson Elias - - 2014
BackgroundAlthough it is preferable that all patients with a recent Transient Ischemic Attack (TIA) undergo acute carotid imaging, there are centers with limited access to such acute examinations. It is controversial whether ABCD2 or ABCD3 scores can be used to triage patients to acute or delayed carotid imaging. It would ...
Papi Enrica E Department of Bioengineering, University of Strathclyde, Wolfson Building, 106 Rottenrow, Glasgow, G4 0NW, UK; Department of Surgery and Cancer, Imperial College London, Room 7L16, Floor 7, Laboratory Block, Charing Cross Hospital, London, W6 8RF, UK. Electronic address: - - 2014
This study investigated the feasibility of the uncontrolled manifold approach (UCM) to analyse gait data variability in relation to the control of the centre of mass (COM) in adults with and without neuropathology. The proposed method was applied to six able-bodied subjects to characterise mechanisms of normal postural control during ...
Milionis Haralampos H Neurology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland; Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, - - 2014
It is still debatable whether anemia predicts stroke outcome. To describe the characteristics of patients with acute ischemic stroke (AIS) and anemia and identify whether hemoglobin status on admission is a prognostic factor of AIS outcome. All 2439 patients of the Acute Stroke Registry and Analysis of Lausanne (ASTRAL) between ...
Hao Yong Y Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, No. 168 Changhai Road, Shanghai, 200433, People's Republic of - - 2014
Neuroinflammation, influenced by IL-18, has been suggested to be implicated in the pathophysiological mechanisms of stroke. However, the relative contribution and exact mechanisms of IL-18 remain ambiguous. The aim of this meta-analysis is to compare serum IL-18 levels between stroke patients and controls among different ethnic groups. Potential relevant studies ...
Golicki Dominik D Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Banacha 1B St., 02-097, Warsaw, Poland, - - 2014
To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness of EQ-5D-3L and visual analogue scale (EQ VAS). We performed an ...
Ruppert Elisabeth E Department of Neurology, Sleep and Electrophysiology Clinic, Hôpital Civil, Strasbourg, - - 2014
Background: Given the discordant results of studies that have reported cases of RLS associated with brainstem stroke and the absence of RLS in large series describing the clinical spectrum of brainstem infarctions, we decided to assess RLS in all patients admitted for brainstem stroke. Methods: All patients who were consecutively ...
Sharma Ashish A Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address: - - 2014
Although chronic risk factors for stroke are reasonably well understood, the acute precipitants, or triggers, of stroke relatively remain understudied. Identification of particular time periods during which stroke risk is elevated could prove a valuable strategy to reduce stroke incidence through the introduction of appropriate prevention strategies during a period ...
Ho Chi-Wai CW From the Cardiology Division (C.-W.H., M.-H.H., P.-H.C., J.-J.H., E.C., C.-P.L., H.-F.T., C.-W.S.), Endocrinology Division (C.-Y.Y.), and Neurology Division (K.-K.L., K.-H.C.), Department of Medicine, Queen Mary Hospital and Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine (G.K.-K.L.), University of Hong Kong, Hong Kong SAR, China; and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, University Department of Medicine, Birmingham, United Kingdom - - 2014
Little is known about the impact of quality of anticoagulation control, as reflected by time in therapeutic range (TTR), on the effectiveness and safety of warfarin therapy in Chinese patients with atrial fibrillation. We investigated the risks of ischemic stroke and intracranial hemorrhage (ICH) in relation to warfarin at various ...
Yamauchi Hiroshi H From the Division of PET Imaging, Shiga Medical Centre Research Institute, Shiga, Japan. - - 2014
The benefit of strict blood pressure (BP) control in high-risk patients with symptomatic major cerebral artery disease and misery perfusion (MP) is controversial. Our purposes were (1) to determine whether MP is a predictor of a 5-year risk of subsequent stroke and (2) to investigate the relationships among BP during ...
Kongbunkiat Kannikar K 1Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, - - 2014
Abstract Purpose: To study factors associated with poor outcomes in acute ischemic stroke patients with AF by using a national database. Materials and Methods: This study was a retrospective analytical study by retrieving data from the Thailand national database system for universal coverage health insurance system. All adult patients aged ...
Ha Andrew C T AC aPeterMunk Cardiac Center, University Health Network, Toronto, Canada bDepartment of Electrophysiology, Heart Center, University of Leipzig, Leipzig, Germany cUniversity of Ottawa Heart Institute, Ottawa dSouthlake Regional Health Centre, Newmarket, Ontario, - - 2014
Catheter ablation for atrial fibrillation is an effective rhythm-control therapy for selected patients. Currently, it is unknown whether maintenance of sinus rhythm after atrial fibrillation ablation can reduce one's stroke risk. If so, this may potentially obviate the need to treat patients with long-term oral anticoagulation (OAC). This article reviews ...
Chen Chung-Yao CY Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: - - 2014
The role of obstructive sleep apnea (OSA) in the mortality and further cardiovascular risk in subjects with ischemic stroke remains a contentious issue. Oxidative stress and inflammatory reaction due to OSA have seldom been studied in stable ischemic stroke patients. This cross-sectional, prospective study involved 92 consecutive ischemic stroke patients ...
Ntaios George G From the Department of Medicine, Larissa University Hospital, School of Medicine, University of Thessaly, Larissa, Greece (G.N., V.P., K.M.); Department of Medicine, Ioannina University Hospital, School of Medicine, University of Ioannina, Ioannina, Greece (H.M.); Department of Clinical Therapeutics, Medical School of Athens, Alexandra Hospital, Athens, Greece (E.M., K.V.); Department of Neurology, Eginition Hospital, University of Athens Medical School, Athens, Greece (K.S.); and Stroke Center, Neurology Service, CHUV, University of Lausanne, Lausanne, Switzerland (P.M.). - - 2014
A new clinical construct termed embolic stroke of undetermined source (ESUS) was recently introduced, but no such population has been described yet. Our aim is to provide a detailed descriptive analysis of an ESUS population derived from a large prospective ischemic stroke registry using the proposed diagnostic criteria. The criteria ...
Switońska M M Neurology and Stroke Care Unit, Jan Biziel University Hospital No. 2, Bydgoszcz, - - 2014
Stroke is an important cause of death and disability throughout the world. Microparticles play a cardinal role in vascular hemostasis. The primary aim of this study was to evaluate the procoagulant activity of microparticles and levels of tissue-factor-bearing microparticles (MPs-TF), tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in ...
Strømmen Anna Maria AM From the Department of Neurology, Copenhagen University Hospital-Nordsjællands Hospital, Hillerød, Denmark. - - 2014
The purpose of this study was to quantitatively measure and describe the amount and pattern of physical activity in patients within the first week after acute ischemic stroke and transient ischemic attack using accelerometers. A total of 100 patients with acute ischemic stroke or transient ischemic attack admitted to our ...
Lee Jung Myung JM Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, - - 2014
The association between pulmonary vein (PV) dilatation and stroke in non-valvular atrial fibrillation (AF) patients remains unknown. We examined the left atrium (LA) and PV in control (n=138) and non-valvular AF patients without (AF group, n=138) and with non-hemorrhagic stroke (AF with stroke group, n=138) using computed tomography. The LA, ...
Sluggett J K JK Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, - - 2014
Hospital audits may underestimate anticoagulant use among acute ischaemic stroke patients with atrial fibrillation (AF), as treatment may commence after discharge. To account for this, antithrombotic use in the 4 months after hospitalisation for transient ischaemic attack or ischaemic stroke among AF patients was assessed using claims data. Results suggest ...
Tomazic Peter Valentin PV ENT, University Hospital (p.v.t., a.l., d.l-l.); the Institute of Pathology (r.b-g., b.d., s.s.); the Center of Medical Research, Mass Spectrometry Core Facility (s.s.), Medical University of Graz; The Austrian Center of Industrial Biotechnology (r.b-g., b.d., s.s.); and the The Omics Center Graz, BioTechMed (r.b-g., b.d., s.s.), Graz, - - 2014
Nasal mucus is a defense barrier against aeroallergens. We recently found apolipoproteins to be elevated in the nasal mucus of allergic rhinitis patients. Apolipoproteins are involved in lipid metabolism, have immunomodulatory properties, and may represent interesting novel biomarkers. This study aims to validate our findings and analyze whether the increased ...
Wang Jen-Yu JY From the Department of Internal Medicine (J-YW,C-YW, C-HT) and Medical Research Center (T-TC), Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City; Department of Neurology (Y-SH) and Department of Otolaryngology (C-CL), Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi; and School of Medicine (CCL), Tzu Chi University, Hualien, - - 2014
The safety, tolerability, and efficacy data for antipsychotic drugs used in the acute phase of stroke are limited. The primary aim of this study was to examine the effectiveness and safety of typical and atypical antipsychotics on acute ischemic stroke mortality.This observational study was conducted in a retrospective cohort of ...
Boeskov Birgitte B Clinical Motor Function Laboratory, The Parker Institute, Copenhagen University Hospital Bispebjerg and Frederiksberg, - - 2014
Stroke is an important cause of severe disability and impaired motor function. Treatment modalities that improve motor function in patients with stroke are needed. The objective of this study was to investigate the effect of kinesthetic taping of the anterior thigh and knee on maximal walking speed and clinical indices ...
Bembenek J P JP Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, - - 2014
Effective anticoagulation with vitamin K antagonists (VKAs) is the standard of stroke prevention in patients with non-valvular atrial fibrillation (AF). Although, everyday practice is becoming increasingly guideline-driven, proper anticagulation is still problematic. We aimed to investigate changes in the use of VKAs for stroke prevention in patients with AF admitted ...
Man David D Department of Rehabilitation Sciences, Hong Kong Polytechnic University , Hong Kong , PR China - - 2014
Abstract Background and purpose: Prospective memory (PM) is a common problem which can limit performance of basic and instrumental activities of daily living in patients with stroke. This study compared self-report PM failures between older and younger people with stroke, examined differences in perceptions of PM failures between people with ...
Joux Julien J From the Departments of Neurology (J.J., N.C., S.J., M.S.-V., D.S., S.O.), Radiology (M.M.), Vascular Surgery (J.-L.H.), and Pathology (L.D.), Fort-de-France University Hospital, Martinique, French West Indies. - - 2014
An atypical form of fibromuscular dysplasia located in the internal carotid-bulb (CaFMD) is thought to be uncommon and is poorly described as a cause of ischemic stroke in the young. This study aimed to obtain a better description of CaFMD in Afro-Caribbean population, who could be particularly affected by it. ...
Lasek-Bal Anetta A Department of Neurology, Medical University of Silesia Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, - - 2014
Background: An increase in the troponin I (TnI) level is a marker of myocardial damage in acute coronary syndromes (ACS) and other conditions. According to the latest reports, an increase in the concentration of TnI in the acute phase of stroke relates to 1-34% of patients. The aim of this ...
Choi Jay Chol JC Department of Neurology, Jeju National University, Jeju, - - 2014
Spontaneous echo-contrast (SEC) appears on B-mode images as moving curls of smoke in the lumen of veins. The aims of this study were to investigate the prevalence and characteristics of internal jugular vein SEC among patients with stroke, in comparison with control subjects. We enrolled 97 Korean patients with acute ...
Lantz M M Karolinska Institute, Department of Neurology, Karolinska University Hospital, Stockholm, - - 2014
Migraine, especially with aura, is a risk factor for ischemic stroke. In this study, we investigated descriptive data and prevalence of migraine in an in-patient stroke population. Patients with acute cerebrovascular disease (CVD) admitted to the stroke unit during a 6-month period were recruited. Prevalence of migraine was assessed using ...
Reid John M JM Department of Neurology, Aberdeen Royal Infirmary, Aberdeen, Scotland, - - 2014
Debate exists as to whether wake-up stroke (WUS) (i.e. symptoms first noted on waking) differs from stroke developing while awake [awake onset stroke (AOS)]. Unknown onset stroke (UOS) with unclear symptom onset time is infrequently studied. This study aimed to examine differences in stroke characteristics and outcomes in these three ...
Mantokoudis Georgios G *Department of Neurology, Johns Hopkins University School of Medicine; †Johns Hopkins Biostatistics Center; and ‡Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.; §University of Applied Sciences Upper Austria, Department of Medical Engineering, Linz, Austria; and ║University of Illinois College of Medicine, Peoria, Illinois, - - 2014
Vestibular neuritis is often mimicked by stroke (pseudoneuritis). Vestibular eye movements help discriminate the two conditions. We report vestibulo-ocular reflex (VOR) gain measures in neuritis and stroke presenting acute vestibular syndrome (AVS). Prospective cross-sectional study of AVS (acute continuous vertigo/dizziness lasting >24 h) at two academic centers. We measured horizontal ...
Naylor A Ross AR The Department of Vascular Surgery at Leicester Royal Infirmary, Leicester, United Kingdom. Electronic address: - - 2014
Despite level I evidence supporting a role for carotid endarterectomy (CEA) in the management of patients with asymptomatic carotid disease, there is surprisingly little international consensus regarding the optimal way to manage these patients. Review of current strategies for managing asymptomatic carotid disease MAIN FINDINGS: Those favouring a pro-interventional approach ...
Lei Chunyan C Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, Chengdu, P. R. - - 2014
Whether asymptomatic hemorrhagic transformation (HT) is clinically innocuous, that is, unassociated with clinically detectable neurologic deterioration, remains an open question. To explore this, we examined whether asymptomatic HT affects long-term poor outcome and risk of stroke recurrence. We consecutively and prospectively enrolled patients with acute ischemic stroke who were admitted ...
Yao Xiaoying X Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, - - 2014
Background: Elevated maximal clot strength, measured by thrombelastography (TEG) maximum amplitude (MA) has been associated with a higher risk for ischemic events in patients with coronary artery diseases. However, it has not been investigated in patients with cerebrovascular diseases. In the current study, we aimed to evaluate the predictive ability ...
Saposnik Gustavo G From the Division of Neurology, Department of Medicine, Stroke Outcomes Research Center, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (G.S.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Duke Clinical Research Institute, Durham, NC (W.P., L.L., A.F.H.); Stroke Service and Institute for Heart, Vascular and Stroke Care, Massachusetts General Hospital, Boston (L.H.S.); and Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (E.E.S.). - - 2014
Limited information is available on stroke prevention in high-risk patients with preexisting cardiovascular disease. Our aim was to use admission low-density lipoprotein (LDL) values to evaluate differences in the attainment of National Cholesterol Education Program-Adult Treatment Panel III guidelines goals at the time of the index event in high-risk patients ...
Glotzer Taya V TV Hackensack University Medical Center, Hackensack, NJ. Electronic address: - - 2014
Stroke without an identifiable cause is frightening to patients and their families, and frustrating for the caring physician. Approximately 30 percent of patients with cardiac implanted electronic devices have some evidence of atrial fibrillation (AF), and much of it is silent; asymptomatic and previously unrecognized. This review will examine "silent ...
Werner Ralph R Department of Neurology/Stroke Unit, Katholisches Klinikum Koblenz-Montabaur, Koblenz, - - 2014
Background: Angioedema (AE) in stroke has been reported exclusively after thrombolysis with recombinant tissue-type plasminogen activator (rtPA). Previous studies proposed the insular cortex to play a specific role in the development of AE after stroke. We evaluated the incidence of AE in acute stroke and tried to identify the predominantly ...
Vanacker P P Neurology Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, - - 2014
Background: The effects of intravenous thrombolysis on floating thrombi in cervical and intracranial arteries of acute ischemic stroke patients are unknown. Similarly, the best prevention methods of early recurrences remain controversial. This study aimed to describe the clinical and radiological outcome of thrombolyzed strokes with floating thrombi. Methods: We retrospectively ...
Srivastava M V Padma MV Department of Neurology, AIIMS, New Delhi, India. Electronic address: - - 2014
Young stroke patients constitute 15%-30% of all stroke patients in India as against 3.0%-8.5% reported from the West. The mechanisms for stroke in the young may include unconventional risk factors such as infections. We aimed to investigate the role (if any) of Chlamydia pneumoniae antibodies in young patients with acute ...
Kim Ahro A Department of Neurology, Ilsan Paik Hospital, Inje University, 2240 Daewha-dong, Ilsanseo-gu, Goyang City, Gyeonggi-do 411-706, Republic of - - 2014
As the benefit of thrombolytic therapy in acute ischemic stroke is time-dependent, a code stroke program needs to be implemented, maintained, and improved with continuous efforts to expedite thrombolytic therapy. We analyzed the long-term yield and efficiency of our code stroke program. Using a prospective single-center registry, we assessed the ...
Yaghi Shadi S Department of Neurology, College of Physicians and Surgeons (SY, MSVE), and Department of Epidemiology, Mailman School of Public Health (MSVE), Columbia University, New York, - - 2014
Cryptogenic, or unexplained, stroke is present in about 30%-40% of ischemic stroke patients. Pursuing a stroke mechanism is important in such patients to better choose therapy to reduce the stroke recurrence risk. Intracranial vessel imaging and cardiac evaluation with transesophageal echocardiogram and outpatient cardiac monitoring may help identify the stroke ...
Zhang Changqing C Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, - - 2014
Leukoaraiosis (LA) is an indicator of small vessel disease, but little is known about the relationship between the severity of LA and etiologic subtype of ischemic stroke. Our study aimed to investigate the factors associated with the severity of LA and the relationship between the severity of LA and etiologic ...
Novotná Jana J International Clinical Research Center, Department of Neurology, St. Anne's Hospital, Brno, Czech Republic; Masaryk University, Brno, Czech Republic. Electronic address: - - 2014
The hyperdense cerebral artery sign (HCAS) on unenhanced computed tomography (CT) in acute ischemic stroke is a valuable clinical marker, but it remains unclear if HCAS reflects clot composition or stroke etiology. Therefore, variables independently associated with HCAS were identified from a large international data set of patients treated with ...
Schaefer P W PW From the Departments of Radiology (P.W.S., B.P., W.A.C., J.A.H., T.L.-M., O.W., R.G.G., A.J.Y.) and Neurology (L.H.S.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. - - 2014
Selecting acute ischemic stroke patients for reperfusion therapy on the basis of a diffusion-perfusion mismatch has not been uniformly proved to predict a beneficial treatment response. In a prior study, we have shown that combining clinical with MR imaging thresholds can predict clinical outcome with high positive predictive value. In ...
Fjetland L L Department of Radiology, Stavanger University Hospital, Stavanger, Norway; Neuroscience Research Group, Stavanger University Hospital, Stavanger, - - 2014
The direct bridging concept in acute stroke treatment combines intravenous thrombolysis (IVT) and endovascular treatment (EVT). The frequency and extent of reperfusion obtained already due to IVT were evaluated. Additionally undesired events and the clinical outcome were analysed. Fifty-seven acute stroke patients treated with direct bridging were analysed for this ...
Cao Lei L Department of Rehabilitation, Xuanwu Hospital Capital Medical University, Changchun Street, Xicheng District No. 45, Beijing, 100053, People's Republic of - - 2014
Emerging evidence has shown that repetitive transcranial magnetic stimulation (rTMS) may significantly improve cognitive impairment in stroke patients, but individually published studies show inconclusive results. This meta-analysis aimed to derive a more precise estimation of the effects of rTMS on cognitive impairment in stroke patients based on studies published in ...
Cardoso Rhanderson N RN Department of Internal Medicine, University of Miami/Jackson Memorial Hospital, Miami, - - 2014
Chagas' disease (CD) has been associated with an elevated risk of stroke, but current data are conflicting and prospective controlled studies are lacking. We performed a systematic review and meta-analysis examining the association between stroke and CD. PubMed, EMBASE, Cochrane Central, Latin American databases and unpublished data were searched using ...
Nordin Nurdiana - - 2014
Studies of stroke patients undergoing robot-assisted rehabilitation have revealed various kinematic parameters describing movement quality of the upper limb. However, due to the different level of stroke impairment and different assessment criteria and interventions, the evaluation of the effectiveness of rehabilitation program is undermined.This paper presents a systematic review of ...
Toscano Massimiliano M Department of Neurology and Psychiatry, 'Sapienza' University of Rome, Rome, - - 2014
Anger and aggressive behavior (AB) are two of the main post-stroke behavioral manifestations, which could imply both an anger trait (TA) or a state condition of anger (SA). Serotonergic system is thought to play an inhibitory control on aggressive impulse. Nevertheless, whether 5HT has the same role in TA and ...
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