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Prontera Paolo P Medical Genetics Unit, Hospital "S. M. della Misericordia", University of Perugia, Via E. dal Pozzo, 06123, Perugia, Italy, - - 2014
The duplication of the Williams-Beuren syndrome (WBS) region (7q11.23) is a copy number variant associated with autism spectrum disorder (ASD). One of the most intriguing aspects is that the reciprocal microdeletion causes WBS, characterized by hypersociability, marked empathy, and a relative capacity in verbal short-term memory and language. Herein, we ...
Chen Huai H 1 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, No. 151, Yan Jiang Rd, Yuexiu District, Guangzhou City, Guangdong Province 510120, - - 2014
OBJECTIVE. The objective of our study was to evaluate the correlation between pulmonary function indexes determined by low-dose MDCT and those obtained from routine spirometric pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS. Lung function of patients with COPD stages 0-III was evaluated ...
Camilleri Michael M Mayo Clinic, United - - 2014
The gastrointestinal tract is a vast neuroendocrine organ with extensive extrinsic and intrinsic neural circuits that interact to control its function. Circulating and paracrine hormones (amine and peptide) provide further control of secretory, absorptive, barrier, motor and sensory mechanisms that are essential to the digestion and assimilation of nutrients, and ...
Lee Brian B Department of Neurosurgery, University of Southern California, Los Angeles, California, - - 2014
It is understandably devastating when one suffers the loss of function of an upper extremity due to stroke or spinal cord injury (SCI) or a physical loss from amputation. Lives are forever changed and activities that were once routine become a magnitude more difficult. Fortunately, there has been much research ...
Ji Gong-Jun GJ From the Center of Cognitive and Brain Disorders, Hangzhou Normal University, 126 Wenzhou Road, Gongshu District, Hangzhou, Zhejiang 310015, China (G.J.J., Y.F.Z., W.L.); and Department of Medical Imaging, Jinling Hospital, Clinic School of Medical College, Nanjing University, Nanjing, Jiangsu, China (Z.Z., Q.X., - - 2014
Purpose To characterize interhemispheric functional and anatomic connectivity in patients with idiopathic generalized epilepsy and generalized tonic-clonic seizures (GTCS). Materials and Methods This retrospective study was approved by the local institutional review board and was HIPAA compliant. All participants provided written informed consent. Resting-state functional and structural magnetic resonance images ...
Wang Junjing J Center for the Study of Applied Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, - - 2014
Temporal lobe epilepsy (TLE) is one of the most common forms of drug-resistant epilepsy. Previous studies have indicated that the TLE-related impairments existed in extensive local functional networks. However, little is known about the alterations in the topological properties of whole brain functional networks. In this study, we acquired resting-state ...
Altundag Aytug A From the *Division of Otorhinolaryngology, Istanbul Surgery Hospital; and Departments of †Otorhinolaryngology, ‡Neurology, and §Radiology, Gülhane Military Medical Academy (GATA) Haydarpaşa Training Hospital, Istanbul; and ∥Department of Otorhinolaryngology, Amasya University Training and Research Hospital, Amasya, Turkey; and #Smell & Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, - - 2014
One of the most common reasons for partial nasal obstruction is nasal septal deviation (NSD). The effect of a partial lateralized nasal obstruction on olfactory bulb (OB) volume remains unclear. Thus, the aim of this study was to investigate the side differences in olfactory function and OB in patients with ...
Zhang Jing J From the Department of Radiology, Tianjin Key Laboratory of Functional Imaging (J.Z., L.M., W.Q., N.L., C.Y.) and Department of Neurology, Tianjin Neurological Institute (F.-D.S.), Tianjin Medical University General Hospital, Tianjin, - - 2014
Both structural atrophy and functional reorganization of the primary motor cortex (M1) have been reported in patients with subcortical infarctions affecting the motor pathway. However, the relationship between structural impairment and functional reorganization in M1 remains unclear. Twenty-six patients exhibiting significant recovery after subcortical infarctions were investigated using multimodal MRI ...
Cosío Borja G BG Department of Respiratory Medicine, Hospital Universitario Son Espases and Instituto de Investigación Sanitaria de Palma (IdISPa), , Palma de Mallorca, - - 2014
Fibred confocal fluorescence microscopy (FCFM) is a novel technology that allows the in vivo assessment and quantification during bronchoscopy of the bronchial wall elastic fibre pattern, alveolar and vessel diameters and thickness of the elastic fibre in the alveolar wall. To relate these structural characteristics with lung function parameters in ...
Ni Ling L From the Departments of Medical Imaging (L.N., L.J.Z., R.Q., Q.X., X.L., G.Z., G.M.L.) and Nephrology (J.W.), Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province 210002, China;Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY (T.Z.); and Department of Biomedical Engineering, Zhejiang University, Hangzhou, China - - 2014
Purpose To investigate the functional connectivity of the default-mode network (DMN) in patients with end-stage renal disease (ESRD) by using independent component analysis of resting-state functional magnetic resonance (MR) imaging and to correlate these DMN connectivity changes with neuropsychological test results and clinical biomarkers. Materials and Methods Medical research ethics ...
Watanabe Junko J Department of Rehabilitation Medicine, Fukuoka University Hospital, Fukuoka, - - 2014
Significant carotid stenosis is known to cause ischemic stroke and cognitive impairment. However, it remains controversial whether carotid endarterectomy (CEA) can improve cognitive function in patients with carotid stenosis. We used the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) to compare cognitive function between before and after CEA. ...
Poussel Mathias M Department of Pulmonary Function Testing and Exercise Testing, CHU Nancy, Nancy, F-54000, France; EA 3450 DevAH - Development, Adaptation and Disadvantage. Cardiorespiratory regulations and motor control. Université de Lorraine, F-54000, France. Electronic address: - - 2014
Quality of life and prognosis of patients with myotonic dystrophy type 1 (MD1) often depend on the degree of lung function impairment. This study was designed to assess the respective prevalence of ventilatory restriction, hypoxaemia and hypercapnia in MD1 patients and to determine whether postural changes in lung function could ...
Ozer Necla N Department of Cardiology, Faculty of Medicine, Hacettepe University, Ankara-Turkey. - - 2014
In this study, we aimed to evaluate the impact of cabergoline use in patients with Parkinson's disease on valvular and biventricular functions. In this observational cohort study, patients with Parkinson disease were divided into 2 groups as 34 patients (41.2% female, age; 57.4±15.3 years) using cabergoline (Group 1) and 42 ...
Redal-Baigorri Belén B Department of Nephrology, Roskilde University Hospital, University of Copenhagen, Roskilde, - - 2013
Kidney function is mostly expressed in terms of glomerular filtration rate (GFR). A common feature is the expression as ml/min per 1.73 m(2) , which represents the adjustment of the individual kidney function to a standard body surface area (BSA) to allow comparison between individuals. We investigated the impact of ...
Iovino Paola P Paola Iovino, Carolina Ciacci, Gastrointestinal Unit, Department of Medicine and Surgery, University of Salerno, 84081 Salerno, - - 2013
Impaired gastric accommodation is one of the most important etiologic factors in the pathophysiology of functional dyspepsia. Ultrasound is a potential alternative method to study changes in gastric volume as a reflection of gastric accommodation. Ultrasound is suitable for patients because it is a non-invasive, easily repeated and non-radioactive procedure, ...
Zanier Elisa R ER From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri (E.R.Z., R.Z., F.O., M.T., M.-G.D.S.), Department of Neuroscience, Milan; Department of Physiopathology and Transplant, Milan University and Neuro ICU (R.Z., T.Z., V.C., N.S.), Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; and Laboratory of Molecular Medicine (L.M.-F., E.H., P.G.), Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, - - 2013
To assess the involvement of ficolin-3, the main initiator of the lectin complement pathway (LCP), in subarachnoid hemorrhage (SAH) pathology and outcome. In this preliminary exploratory study, plasma concentration of ficolin-3 and of ficolin-3-mediated functional LCP activity was measured, along with that of other LCP initiators (mannose-binding lectin, ficolin-2, and ...
Doyle Tracy J - - 2013
Approximately 10% of rheumatoid arthritis (RA) patients have interstitial lung disease (ILD) and one-third have subclinical ILD on chest CT. In this study, we aim to further characterize functional decrements in a spectrum of RA-ILD. All subjects were enrolled in the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS). ...
Zhao Lu - - 2013
Obesity paradox has been reported because of the inverse relationship between the body mass index (BMI) and mortality in stroke patients. The relationship between BMI and functional recovery in stroke survivors is less well established. We explored the impact of BMI on functional recovery and mortality in stroke patients in ...
Tessitore Alessandro - - 2013
Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated disrupted default mode network (DMN) connectivity in a number of pain conditions, including migraine. However, the significance of altered resting-state brain functional connectivity in migraine is still unknown. The present study is aimed to explore DMN functional connectivity in patients with migraine ...
Geyik B - - 2013
It is clinically important to evaluate the severity of right ventricular (RV) overload in patients with chronic obstructive pulmonary disease (COPD), which is often associated with changes in the structure and the function of the right ventricle. Noninvasive and reliable assessment of RV function would be an essential determinant of ...
Arntz Renate M - - 2013
To determine the influence of poststroke epilepsy on long-term functional outcome in young stroke survivors. This study is a prospective cohort study among 537 stroke survivors with a first-ever TIA, ischemic stroke, or intracerebral hemorrhagic (ICH) stroke, aged 18 to 50 years. After a mean follow-up of 9.8 years (SD ...
Agosta Federica - - 2013
Resting state functional connectivity of the sensorimotor and extramotor brain networks was studied in 24 patients with primary lateral sclerosis (PLS) relative to 26 healthy controls. The relationships of RS functional connectivity with patient clinical and cognitive status and white matter tract damage (i.e., corticospinal tracts, corpus callosum, and superior ...
Hirano Tsunahiko - - 2013
Nitrative stress is thought to be involved in the inflammatory process in COPD airways, and the alveolar nitric oxide concentration (CAlv) has been reported to be increased. However, the CAlv levels are also regulated by gas diffusion at alveolar sites. The aim of the study was to assess the relationship ...
Björkman Eleonora Victoria Charlotta - - 2013
Abstract Background and aims. Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function. However, the influence of acid and/or bile acids on human esophageal epithelial barrier function and the tight junction (TJ) proteins has not been fully elucidated. The aim of the study is to investigate the esophageal ...
Verma Rajesh - - 2013
Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy with varied severity of presentation. To study the clinical and electrophysiological profile of patients with GBS and to determine the factors associated with poor functional outcome and need for mechanical ventilation. It was a hospital-based prospective observational study. 90 patients with GBS diagnosed ...
Andrea Rut - - 2013
Heart failure with preserved ejection fraction (HFPEF) is the most prevalent form of heart failure in outpatients. Yet, the pathophysiology of this syndrome is unclear and pharmacological treatment does not improve prognosis. Because breathlessness during activities of daily living is the most frequent complaint of patients with HFPEF, we hypothesised ...
Lee Seojung S Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of - - 2013
Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. Twenty one alcohol dependent patients and 24 age-matched healthy controls performed a decision-making task during functional MRI. We defined the medial orbitofrontal ...
Sato Emiko - - 2013
It is important to understand dysphagia in patients with dementia, as it is associated with malnutrition and aspiration pneumonia. Particularly in patients with Alzheimer's disease (AD), mortality from pneumonia is high and accounts for 70% of the causes of death. However, the standard swallowing tests are often difficult to use ...
Eom Jung Seop - - 2013
Although elongated morphological changes in the trachea are known to be related to lung function in chronic obstructive pulmonary disease (COPD), whether the tracheal morphological changes are associated with airflow limitations or overinflation of the lung in the early stages of COPD has not yet been determined. Thus, our aim ...
Foster Paul S - - 2013
The cerebral hemispheres are differentially involved in regulating immunological functioning and the neuropathology associated with Alzheimer's disease (AD) is asymmetrical. Thus, subgroups of AD patients may exhibit different patterns of immunological dysfunction. We explored this possibility in a group of AD patients and found that patients with low white blood ...
Fernandes Alessandro Murano Ferré - - 2013
Multiple sclerosis is a neurological disease that involves swallowing disorders. Many studies have shown an association between neurological and swallowing performance, but results have been conflicting. To identify the frequency of dysphagia in patients with multiple sclerosis and neurological indicators that can represent the performance of swallowing. In this study ...
Aizawa Carolina Yuri P - - 2013
To assess balance and ability to function in patients with spinocerebellar ataxia. A total of 44 patients with different spinocerebellar ataxia types 1, 2, 3, and 6 were evaluated using the Tinetti balance and gait assessment and the functional independence measure. The scale for the assessment and rating of ataxia ...
Brittain Evan L - - 2013
We hypothesized that RV stroke work index (RVSWI) and pulmonary capacitance (PC) would increase after treatment for pulmonary arterial hypertension (PAH) and that prostanoids would have a stronger effect than oral therapy. Right ventricular (RV) function is a major determinant of outcome in patients with PAH. Little is known about ...
Alary Mathieu - - 2013
It is widely reported that patients with schizophrenia exhibit decreased hemispheric lateralization. However, no study has evaluated relationships between the hemispheric anatomical and functional asymmetry in language areas. The present study aimed to determine whether decreased leftward hemispheric lateralization could be related to asymmetry of the grey matter volume in ...
Chern Jen-Suh - - 2013
The purpose was to examine the effects of static anterior and posterior ankle-foot orthoses (AAFOs & PAFOs) using with regular shoes on improving static and gait function in patients recovering from stroke. Static and dynamic balance control were measured under four conditions: barefeet, wearing regular shoes only, and wearing regular ...
Cha Jungho - - 2013
Most default mode network (DMN) studies in patients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) are based on the comparison of only two groups, namely patients and controls. Information derived from comparing three groups, normal, aMCI and AD, simultaneously may lead us to better understand the progression ...
Valderramas Silvia - - 2013
To describe the intra-rater and inter-rater reliability of the Brazilian Portuguese version of the fatigue severity scale (FSS) in patients with COPD and to identify the presence of its association with parameters of pulmonary function, dyspnea, and functional capacity. This was an observational cross-sectional study involving 50 patients with COPD, ...
Oertel-Knöchel Viola - - 2013
The planum temporale (PT) is a highly lateralized brain area associated with auditory and language processing. In schizophrenia, reduced structural and functional laterality of the PT has been suggested, which is of clinical interest because of its potential role in the generation of auditory verbal hallucinations. We investigated whether resting-state ...
Arslan Uğur - - 2013
OBJECTIVE: Cardiac resynchronization therapy (CRT) improves heart rate variability (HRV) and heart rate turbulence (HRT) parameters. Herein, our aim was to compare these parameters with intracardiac- cardioverter defibrillator (ICD) patients with similar functional status to detect possible additional benefits of CRT on autonomic functions. METHODS: Patients who had systolic HF ...
Leblanc A - - 2013
Asthma is a complex disease with numerous markers of severity/activity. Clinical assessment,functional parameters and inflammation biomarkers are the most used A correlation between them is difficult, as each one evaluates a particular aspect of the disease. To explore the possible association between asthma control, pulmonary function and inflammation in patients ...
Zhang S S - - 2013
Conventional total superficial parotidectomy (TP) has commonly been used, but partial superficial parotidectomy (PP) offers the possibility of better preserving glandular function and avoiding palsy of the facial nerves. In this study, the extent to which saliva secretion and facial nerve function were conserved in patients who received TP vs. ...
Tarapore Phiroz E - - 2013
Object Traumatic brain injury (TBI) is one of the leading causes of morbidity worldwide. One mechanism by which blunt head trauma may disrupt normal cognition and behavior is through alteration of functional connectivity between brain regions. In this pilot study, the authors applied a rapid automated resting state magnetoencephalography (MEG) ...
Solovykh E A - - 2013
Analysis of correlations of the functional parameters of the stomatognathic and postural systems with sub-, decompensated, and compensated status was carried out. Disorders in the masticatory muscle activity and interactions between the postural and stomatognathic systems were detected in patients with sub- and decompensated functional status. A significant correlation between ...
Ben Fredj H - - 2013
Background: The rheumatoid polyarthritis (PR) is a frequent pathology in Tunisia. The most frequent extra articular expression of this disease is in the respiratory tract. aim: To determine the lung functional profile of PR of the Tunisian population by establishing possible relations between ventilatory variables and clinico-biological parameters of PR. ...
Gatta G - - 2013
The purpose of the study was to identify the correlation between functional lung parameters to the extent of lung involvement evaluated by High Resolution Computed Tomography (HRCT) in systemic sclerosis (SSc), using a modified score scale. Forty-two patients with established clinical diagnosis of systemic sclerosis were retrospectively selected from the ...
Komuro Ayako - - 2013
Cerebellar stroke rarely causes disorders of higher brain function such as cognitive deficits and emotional dysfunction; hence, the prognosis of these patients is uncertain. We report the case of a 34-year-old patient with cerebellar hemorrhage due to arteriovenous malformation causing higher brain dysfunction who was able to return to full-time ...
Tjora E - - 2013
OBJECTIVES: To examine the exocrine pancreatic function in carriers of the hepatocyte nuclear factor 1β gene (HNF1B) mutation by direct testing. METHODS: Patients with HNF1B mutations and control subjects were assessed using rapid endoscopic secretin tests and secretin-stimulated magnetic resonance imaging. Seven patients and 25 controls underwent endoscopy, while eight ...
Lin Hui - - 2013
Lung injury commonly accompanies uremia caused by renal failure. Uremia is typically treated using hemodialysis (dialysis) to restore electrolyte and fluid balance. A more recent, less commonly used method, high-flux dialysis, has not yet been investigated for its potential benefit to lung function. The aim of the present study was ...
Jang Sung Ho - - 2013
Somatosensory dysfunction is associated with a high incidence of functional impairment and safety in patients with stroke. With developments in brain mapping techniques, many studies have addressed the recovery of various functions in such patients. However, relatively little is known about the mechanisms of recovery of somatosensory function. Based on ...
Kon Valentina - - 2013
PURPOSE OF REVIEW: This review will examine advances in our understanding of the association between high-density lipoprotein (HDL) function and cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). RECENT FINDINGS: Large randomized statin trials and related meta-analyses confirm that lipid-lowering therapy benefits patients with mild to moderate CKD, ...
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