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Jude Madu Anazoeze MA Department of Haematology & Immunology, University of Nigeria Enugu Campus (UNEC), - - 2014
Stroke is a life-changing, debilitating complication of sickle cell disease (SCD). Previous studies had recorded high stroke prevalence amongst this group of patients. Nigeria has a large population of people affected by this condition and this study aims to assess the stroke prevalence in this large population. Stroke prevalence data ...
Cho Soo-Kyung SK 0000-0003-4493-8837 Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, - - 2014
The aim of the present study was to identify the influence of vertebral fracture (VF) on the functional disability in patients with rheumatoid arthritis (RA). This study consecutively enrolled 100 female patients aged 50 yr or older with RA. All participants underwent lateral imaging of the thoracolumbar spine by simple ...
Beck Dt D Department of Kinesiology, University of Rhode Island, Kingston, RI, - - 2014
Enhanced external counterpulsation (EECP) therapy decreases angina episodes and improves quality of life in patients with left ventricular dysfunction (LVD). However, studies have not elucidated the mechanisms of action and overall effects of EECP in patients with LVD. The purpose of this study was to investigate the effects of EECP ...
Ogata Toshiyasu T Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan ; Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, - - 2014
Gastrointestinal (GI) hemorrhage is a potentially serious complication of acute stroke, but its incidence appears to be decreasing. The aim of this study was to elucidate the etiology of GI bleeding and its impact on clinical outcomes in patients with acute ischemic stroke in recent years. Using the database of ...
Prontera Paolo P Medical Genetics Unit, Hospital "S. M. della Misericordia", University of Perugia, Via E. dal Pozzo, 06123, Perugia, Italy, - - 2014
The duplication of the Williams-Beuren syndrome (WBS) region (7q11.23) is a copy number variant associated with autism spectrum disorder (ASD). One of the most intriguing aspects is that the reciprocal microdeletion causes WBS, characterized by hypersociability, marked empathy, and a relative capacity in verbal short-term memory and language. Herein, we ...
Shaafi Sheyda S Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, - - 2014
Interleukin-6 (IL-6) is one of the inflammatory mediators characterized by elevated levels in ischemic stroke (IS) patients. The present study set out to assess the role of IL-6, as a marker for inflammation, in the severity and prognosis of acute IS. In a cross-sectional descriptive study, 45 patients with acute ...
Chen Huai H 1 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, No. 151, Yan Jiang Rd, Yuexiu District, Guangzhou City, Guangdong Province 510120, - - 2014
OBJECTIVE. The objective of our study was to evaluate the correlation between pulmonary function indexes determined by low-dose MDCT and those obtained from routine spirometric pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS. Lung function of patients with COPD stages 0-III was evaluated ...
Camilleri Michael M Mayo Clinic, United - - 2014
The gastrointestinal tract is a vast neuroendocrine organ with extensive extrinsic and intrinsic neural circuits that interact to control its function. Circulating and paracrine hormones (amine and peptide) provide further control of secretory, absorptive, barrier, motor and sensory mechanisms that are essential to the digestion and assimilation of nutrients, and ...
Lee Brian B Department of Neurosurgery, University of Southern California, Los Angeles, California, - - 2014
It is understandably devastating when one suffers the loss of function of an upper extremity due to stroke or spinal cord injury (SCI) or a physical loss from amputation. Lives are forever changed and activities that were once routine become a magnitude more difficult. Fortunately, there has been much research ...
Ji Gong-Jun GJ From the Center of Cognitive and Brain Disorders, Hangzhou Normal University, 126 Wenzhou Road, Gongshu District, Hangzhou, Zhejiang 310015, China (G.J.J., Y.F.Z., W.L.); and Department of Medical Imaging, Jinling Hospital, Clinic School of Medical College, Nanjing University, Nanjing, Jiangsu, China (Z.Z., Q.X., - - 2014
Purpose To characterize interhemispheric functional and anatomic connectivity in patients with idiopathic generalized epilepsy and generalized tonic-clonic seizures (GTCS). Materials and Methods This retrospective study was approved by the local institutional review board and was HIPAA compliant. All participants provided written informed consent. Resting-state functional and structural magnetic resonance images ...
Wang Junjing J Center for the Study of Applied Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, - - 2014
Temporal lobe epilepsy (TLE) is one of the most common forms of drug-resistant epilepsy. Previous studies have indicated that the TLE-related impairments existed in extensive local functional networks. However, little is known about the alterations in the topological properties of whole brain functional networks. In this study, we acquired resting-state ...
Altundag Aytug A From the *Division of Otorhinolaryngology, Istanbul Surgery Hospital; and Departments of †Otorhinolaryngology, ‡Neurology, and §Radiology, Gülhane Military Medical Academy (GATA) Haydarpaşa Training Hospital, Istanbul; and ∥Department of Otorhinolaryngology, Amasya University Training and Research Hospital, Amasya, Turkey; and #Smell & Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, - - 2014
One of the most common reasons for partial nasal obstruction is nasal septal deviation (NSD). The effect of a partial lateralized nasal obstruction on olfactory bulb (OB) volume remains unclear. Thus, the aim of this study was to investigate the side differences in olfactory function and OB in patients with ...
Zhang Jing J From the Department of Radiology, Tianjin Key Laboratory of Functional Imaging (J.Z., L.M., W.Q., N.L., C.Y.) and Department of Neurology, Tianjin Neurological Institute (F.-D.S.), Tianjin Medical University General Hospital, Tianjin, - - 2014
Both structural atrophy and functional reorganization of the primary motor cortex (M1) have been reported in patients with subcortical infarctions affecting the motor pathway. However, the relationship between structural impairment and functional reorganization in M1 remains unclear. Twenty-six patients exhibiting significant recovery after subcortical infarctions were investigated using multimodal MRI ...
Cosío Borja G BG Department of Respiratory Medicine, Hospital Universitario Son Espases and Instituto de Investigación Sanitaria de Palma (IdISPa), , Palma de Mallorca, - - 2014
Fibred confocal fluorescence microscopy (FCFM) is a novel technology that allows the in vivo assessment and quantification during bronchoscopy of the bronchial wall elastic fibre pattern, alveolar and vessel diameters and thickness of the elastic fibre in the alveolar wall. To relate these structural characteristics with lung function parameters in ...
Ni Ling L From the Departments of Medical Imaging (L.N., L.J.Z., R.Q., Q.X., X.L., G.Z., G.M.L.) and Nephrology (J.W.), Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province 210002, China;Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY (T.Z.); and Department of Biomedical Engineering, Zhejiang University, Hangzhou, China - - 2014
Purpose To investigate the functional connectivity of the default-mode network (DMN) in patients with end-stage renal disease (ESRD) by using independent component analysis of resting-state functional magnetic resonance (MR) imaging and to correlate these DMN connectivity changes with neuropsychological test results and clinical biomarkers. Materials and Methods Medical research ethics ...
Watanabe Junko J Department of Rehabilitation Medicine, Fukuoka University Hospital, Fukuoka, - - 2014
Significant carotid stenosis is known to cause ischemic stroke and cognitive impairment. However, it remains controversial whether carotid endarterectomy (CEA) can improve cognitive function in patients with carotid stenosis. We used the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) to compare cognitive function between before and after CEA. ...
Poussel Mathias M Department of Pulmonary Function Testing and Exercise Testing, CHU Nancy, Nancy, F-54000, France; EA 3450 DevAH - Development, Adaptation and Disadvantage. Cardiorespiratory regulations and motor control. Université de Lorraine, F-54000, France. Electronic address: - - 2014
Quality of life and prognosis of patients with myotonic dystrophy type 1 (MD1) often depend on the degree of lung function impairment. This study was designed to assess the respective prevalence of ventilatory restriction, hypoxaemia and hypercapnia in MD1 patients and to determine whether postural changes in lung function could ...
Ozer Necla N Department of Cardiology, Faculty of Medicine, Hacettepe University, Ankara-Turkey. - - 2014
In this study, we aimed to evaluate the impact of cabergoline use in patients with Parkinson's disease on valvular and biventricular functions. In this observational cohort study, patients with Parkinson disease were divided into 2 groups as 34 patients (41.2% female, age; 57.4±15.3 years) using cabergoline (Group 1) and 42 ...
Sun Yu Y Singapore Institute for Neurotechnology (SINAPSE), Center for Life Sciences, National University of Singapore, Singapore; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, - - 2014
Although anomalies in the topological architecture of whole-brain connectivity have been found to be associated with Alzheimer's disease (AD), our understanding about the progression of AD in a functional connectivity (FC) perspective is still rudimentary and few study has explored the function-structure relations in brain networks of AD patients. By ...
Fling Brett W BW Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States of - - 2014
Freezing of gait (FoG) is a transient inability to initiate or maintain stepping that often accompanies advanced Parkinson's disease (PD) and significantly impairs mobility. The current study uses a multimodal neuroimaging approach to assess differences in the functional and structural locomotor neural network in PD patients with and without FoG ...
Tinazzi Michele M Department of Neurological and Movement Sciences, University of Verona, Verona, - - 2014
In order to obtain further information on the pathophysiology of functional tremor, we assessed tactile discrimination threshold and proprioceptive temporal discrimination motor threshold values in 11 patients with functional tremor, 11 age- and sex-matched patients with essential tremor and 13 healthy controls. Tactile discrimination threshold in both the right and ...
Adriaanse Sofie M SM Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, Amsterdam, The - - 2014
Early-onset Alzheimer's disease (AD) patients present a different clinical profile than late-onset AD patients. This can be partially explained by cortical atrophy, although brain organization might provide more insight. The aim of this study was to examine functional connectivity in early-onset and late-onset AD patients. Resting-state fMRI scans of 20 ...
Kotaki Kenji K Department of Cardiopulmonary Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, - - 2014
We sought to elucidate the long-term association of tobacco use and respiratory health in designated pollution victims with and without obstructive pulmonary defects. A retrospective cross-sectional study. The register of pollution victims in Kurashiki, Japan. 730 individuals over 65 years of age previously diagnosed with pollution-related respiratory disease. Patients were classified ...
Xu Xue X Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou. - - 2014
YKL-40 is a novel inflammatory protein. Elevated serum levels of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases, but the circulating profile of YKL-40 in patients with cerebrovascular disease has  been less investigated. This prospective observational study aimed to determine serum levels of YKL-40 in patients ...
Wouters Anke A KU Leuven Department of Neurosciences and Experimental Neurology, KU Leuven , Leuven , Belgium ; Department of Neurology, University Hospital Leuven , Leuven , Belgium ; Medical Imaging Research Center, UZ Leuven , Leuven , - - 2014
Patients, who wake up with an ischemic stroke, account for a large number of the total stroke population, due to circadian morning predominance of stroke. Currently, this subset of patients is excluded from revascularization-therapy since no exact time of onset is known. A large group of these patients might be ...
Li Wei W Key Laboratory of Image Processing and Intelligent Control, Ministry of Education, Wuhan, Hubei Province, China ; Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei Province, - - 2014
Studies have shown that functional network connection models can be used to study brain network changes in patients with schizophrenia. In this study, we inferred that these models could also be used to explore functional network connectivity changes in stroke patients. We used independent component analysis to find the motor ...
Redal-Baigorri Belén B Department of Nephrology, Roskilde University Hospital, University of Copenhagen, Roskilde, - - 2013
Kidney function is mostly expressed in terms of glomerular filtration rate (GFR). A common feature is the expression as ml/min per 1.73 m(2) , which represents the adjustment of the individual kidney function to a standard body surface area (BSA) to allow comparison between individuals. We investigated the impact of ...
Iovino Paola P Paola Iovino, Carolina Ciacci, Gastrointestinal Unit, Department of Medicine and Surgery, University of Salerno, 84081 Salerno, - - 2013
Impaired gastric accommodation is one of the most important etiologic factors in the pathophysiology of functional dyspepsia. Ultrasound is a potential alternative method to study changes in gastric volume as a reflection of gastric accommodation. Ultrasound is suitable for patients because it is a non-invasive, easily repeated and non-radioactive procedure, ...
Zanier Elisa R ER From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri (E.R.Z., R.Z., F.O., M.T., M.-G.D.S.), Department of Neuroscience, Milan; Department of Physiopathology and Transplant, Milan University and Neuro ICU (R.Z., T.Z., V.C., N.S.), Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; and Laboratory of Molecular Medicine (L.M.-F., E.H., P.G.), Department of Clinical Immunology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, - - 2013
To assess the involvement of ficolin-3, the main initiator of the lectin complement pathway (LCP), in subarachnoid hemorrhage (SAH) pathology and outcome. In this preliminary exploratory study, plasma concentration of ficolin-3 and of ficolin-3-mediated functional LCP activity was measured, along with that of other LCP initiators (mannose-binding lectin, ficolin-2, and ...
Doyle Tracy J - - 2013
Approximately 10% of rheumatoid arthritis (RA) patients have interstitial lung disease (ILD) and one-third have subclinical ILD on chest CT. In this study, we aim to further characterize functional decrements in a spectrum of RA-ILD. All subjects were enrolled in the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS). ...
Chen Hao H Cancer Research Program; JLC-BBRI; North Carolina Central University; Durham, NC - - 2013
The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we discuss the involvement of NFkB and Nrf2 ...
Zhao Lu - - 2013
Obesity paradox has been reported because of the inverse relationship between the body mass index (BMI) and mortality in stroke patients. The relationship between BMI and functional recovery in stroke survivors is less well established. We explored the impact of BMI on functional recovery and mortality in stroke patients in ...
Tessitore Alessandro - - 2013
Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated disrupted default mode network (DMN) connectivity in a number of pain conditions, including migraine. However, the significance of altered resting-state brain functional connectivity in migraine is still unknown. The present study is aimed to explore DMN functional connectivity in patients with migraine ...
Bao Xiao X Department of Rehabilitation Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, - - 2013
The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains unclear. In this study, 18 healthy subjects ...
Geyik B - - 2013
It is clinically important to evaluate the severity of right ventricular (RV) overload in patients with chronic obstructive pulmonary disease (COPD), which is often associated with changes in the structure and the function of the right ventricle. Noninvasive and reliable assessment of RV function would be an essential determinant of ...
Arntz Renate M - - 2013
To determine the influence of poststroke epilepsy on long-term functional outcome in young stroke survivors. This study is a prospective cohort study among 537 stroke survivors with a first-ever TIA, ischemic stroke, or intracerebral hemorrhagic (ICH) stroke, aged 18 to 50 years. After a mean follow-up of 9.8 years (SD ...
Agosta Federica - - 2013
Resting state functional connectivity of the sensorimotor and extramotor brain networks was studied in 24 patients with primary lateral sclerosis (PLS) relative to 26 healthy controls. The relationships of RS functional connectivity with patient clinical and cognitive status and white matter tract damage (i.e., corticospinal tracts, corpus callosum, and superior ...
Hirano Tsunahiko - - 2013
Nitrative stress is thought to be involved in the inflammatory process in COPD airways, and the alveolar nitric oxide concentration (CAlv) has been reported to be increased. However, the CAlv levels are also regulated by gas diffusion at alveolar sites. The aim of the study was to assess the relationship ...
Björkman Eleonora Victoria Charlotta - - 2013
Abstract Background and aims. Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function. However, the influence of acid and/or bile acids on human esophageal epithelial barrier function and the tight junction (TJ) proteins has not been fully elucidated. The aim of the study is to investigate the esophageal ...
Verma Rajesh - - 2013
Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy with varied severity of presentation. To study the clinical and electrophysiological profile of patients with GBS and to determine the factors associated with poor functional outcome and need for mechanical ventilation. It was a hospital-based prospective observational study. 90 patients with GBS diagnosed ...
Andrea Rut - - 2013
Heart failure with preserved ejection fraction (HFPEF) is the most prevalent form of heart failure in outpatients. Yet, the pathophysiology of this syndrome is unclear and pharmacological treatment does not improve prognosis. Because breathlessness during activities of daily living is the most frequent complaint of patients with HFPEF, we hypothesised ...
Lee Seojung S Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of - - 2013
Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. Twenty one alcohol dependent patients and 24 age-matched healthy controls performed a decision-making task during functional MRI. We defined the medial orbitofrontal ...
Sato Emiko - - 2013
It is important to understand dysphagia in patients with dementia, as it is associated with malnutrition and aspiration pneumonia. Particularly in patients with Alzheimer's disease (AD), mortality from pneumonia is high and accounts for 70% of the causes of death. However, the standard swallowing tests are often difficult to use ...
Eom Jung Seop - - 2013
Although elongated morphological changes in the trachea are known to be related to lung function in chronic obstructive pulmonary disease (COPD), whether the tracheal morphological changes are associated with airflow limitations or overinflation of the lung in the early stages of COPD has not yet been determined. Thus, our aim ...
Foster Paul S - - 2013
The cerebral hemispheres are differentially involved in regulating immunological functioning and the neuropathology associated with Alzheimer's disease (AD) is asymmetrical. Thus, subgroups of AD patients may exhibit different patterns of immunological dysfunction. We explored this possibility in a group of AD patients and found that patients with low white blood ...
Fernandes Alessandro Murano Ferré - - 2013
Multiple sclerosis is a neurological disease that involves swallowing disorders. Many studies have shown an association between neurological and swallowing performance, but results have been conflicting. To identify the frequency of dysphagia in patients with multiple sclerosis and neurological indicators that can represent the performance of swallowing. In this study ...
Aizawa Carolina Yuri P - - 2013
To assess balance and ability to function in patients with spinocerebellar ataxia. A total of 44 patients with different spinocerebellar ataxia types 1, 2, 3, and 6 were evaluated using the Tinetti balance and gait assessment and the functional independence measure. The scale for the assessment and rating of ataxia ...
Brittain Evan L - - 2013
We hypothesized that RV stroke work index (RVSWI) and pulmonary capacitance (PC) would increase after treatment for pulmonary arterial hypertension (PAH) and that prostanoids would have a stronger effect than oral therapy. Right ventricular (RV) function is a major determinant of outcome in patients with PAH. Little is known about ...
Alary Mathieu - - 2013
It is widely reported that patients with schizophrenia exhibit decreased hemispheric lateralization. However, no study has evaluated relationships between the hemispheric anatomical and functional asymmetry in language areas. The present study aimed to determine whether decreased leftward hemispheric lateralization could be related to asymmetry of the grey matter volume in ...
Chern Jen-Suh - - 2013
The purpose was to examine the effects of static anterior and posterior ankle-foot orthoses (AAFOs & PAFOs) using with regular shoes on improving static and gait function in patients recovering from stroke. Static and dynamic balance control were measured under four conditions: barefeet, wearing regular shoes only, and wearing regular ...
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