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Iwasaki Tomoyuki - - 2011
Background/Aims: Recently, high serum DPP-4 activity was found in patients with NAFLD. Therefore, the possibility of NAFLD adversely influencing the therapeutic effect afforded by DPP-4 inhibitors in type 2 diabetic patients was suggested. Methodology: A total of 20 type 2 DM patients with NAFLD and 85 type 2 DM patients ...
Wahbi Karim - - 2011
To determine incidence and type of major cardiac adverse events in patients with mutated desmin (DES) gene, we retrospectively reviewed baseline medical information, and examined the long-term outcomes of 28 DES patients (17 men, baseline mean age=37.7±14.4years [min=9, max=71]) from 19 families. Baseline studies revealed skeletal muscle involvement in 21 ...
Hersi Ahmad - - 2011
There is a paucity of data on atrial fibrillation (AF) complicating acute coronary syndrome (ACS) in Arabian Gulf countries. Thus, we assessed the incidence of AF in patients with ACS in these countries and examined the associated in-hospital, 30-day, and 1-year adverse outcomes. The population comprised 7930 patients enrolled in ...
Wang Wei - - 2011
Objective To ascertain the safety and function of the transplantation of neonatal pig islets (NPIs) for diabetic patients.Methods NPIs were injected into the hepatic artery of 22 patients. After the transplantation, the patients were treated with a multiple drug immunosuppressive regimens. The first 14 patients were treated with cyclosporine (CsA), ...
Bharati Saswata - - 2011
Dexmedetomidine has predictable, complex, and negative cardiovascular effects that lead to additional adverse effects such as bradycardia and hypotension in up to 42% of patients and might cause profound left ventricular dysfunction and refractory shock. Usually, these temporary effects can be successfully counteracted with atropine, ephedrine, and volume supplementation. Clinicians ...
Baek Seung Don - - 2011
HMG-CoA reductase inhibitors (statins) are widely used to treat hypercholesterolemia. Among the adverse effects associated with these drugs are statin-associated myopathies, ranging from asymptomatic elevation of serum creatine kinase to fatal rhabdomyolysis. Fluvastatin-induced fatal rhabdomyolysis has not been previously reported. We describe here a patient with liver cirrhosis who experienced ...
Torp-Pedersen Christian - - 2011
BACKGROUND: Vernakalant is a novel, relatively atrial-selective antiarrhythmic drug. This analysis assessed the efficacy and safety of intravenous vernakalant for the rapid conversion of atrial fibrillation (AF) to sinus rhythm in patients with a history of ischemic heart disease (IHD). METHODS: The presence of IHD was extracted from the medical ...
Menezes Arnold H - - 2011
Object Hindbrain herniation syndrome, or Chiari malformation Type I (CM-I), occurs frequently with craniovertebral junction (CVJ) abnormalities when there is reduction in the posterior fossa volume. Syringomyelia is often present. Posterior fossa dorsal decompression (PFDD) is typically performed but has adverse results when ventral bone abnormality exists. This paper presents ...
Kern Wolfgang - - 2011
BACKGROUND: In patients with chronic lymphocytic leukemia (CLL), aberrant expression of the T-lineage antigen CD8 was reported in low frequencies. The clinical impact of this phenomenon remains in discussion. METHODS: We analyzed 5,523 patients with CLL (21-97 years) by multiparametric flow cytometry and performed fluorescence in situ hybridization (FISH), immunoglobulin ...
Kim Dong Wook - - 2012
The rapid achievement of effective levels of antiepileptic drugs (AEDs) is required in patients with epilepsy who have a higher risk of seizures, and oral loading of AEDs may be an important consideration in these patients. We performed the present study to investigate the efficacy and tolerability of oral loading ...
Yi Jun Ho - - 2011
PURPOSEThis study attempted to analyze the prognostic role of single nucleotide polymorphism array (SNP-A) -based karyotying in 133 patients with acute myeloid leukemia with normal karyotype (AML-NK), which presents with diverse clinical outcomes, thus requiring further stratification of patient subgroups according to their prognoses. PATIENTS AND METHODSA total of 133 ...
Larsen Janni Lisander - - 2011
To describe the incidence, types and severity of adverse events, related to an accelerated regime of rituximab infusion in patients with various autoimmune diseases. Fifty-four patients with systemic autoimmune disease, to be treated with 1,000 mg of rituximab twice 2 weeks apart, participated. Pre-medication (oral prednisolone, anti-histamine and paracetamol) was administered 1-4 h ...
Mainigi Sumeet K - - 2011
Inappropriate implantable cardioverter-defibrillator (ICD) therapies can lead to significant adverse events and increased mortality. These therapies are often the result of supraventricular tachycardias (SVTs). The objective of this study was to evaluate the incidence of SVT leading to inappropriate shocks in a large cohort of patients with ICDs and assess ...
Mogami Yukiko - - 2011
Patients with epilepsy after encephalitis/encephalopathy (EAE) often have refractory seizures, resulting in polytherapy with the risk of adverse reactions due to anti-epileptic drugs (AEDs). We focused on the characteristics of cutaneous adverse reaction (CAR). In this retrospective study, the medical records of 67 patients who were diagnosed as having EAE ...
Tugal-Tutkun Ilknur - - 2011
To describe a series of patients with bilateral acute iris transillumination, pigment dispersion, and sphincter paralysis. We reviewed the medical records and clinical photographs of 26 patients seen at 5 centers in Turkey and Belgium between March 16, 2006, and July 6, 2010. Observation procedures included clinical examination, anterior segment ...
Lainscak Mitja - - 2011
Chronic obstructive pulmonary disease (COPD) frequently coexists in patients with chronic heart failure (CHF) and is a key factor for beta blocker underprescription and underdosing. This study compared effects of bisoprolol and carvedilol in patients with both conditions. This was a randomized open-label study, of bisoprolol and carvedilol during initiation ...
Imam M H - - 2011
Ursodeoxycholic acid (UDCA) in a dose of 28-30 mg/kg/day increases the likelihood of clinical deterioration of primary sclerosing cholangitis (PSC) patients. To compare the risk of adverse clinical endpoints in patients with varying disease status. We reviewed records from patients previously enrolled in a study evaluating the effects of high dose ...
Goeminne Pieter C - - 2011
Rheumatic diseases as well as inflammatory bowel disease (IBD) have been associated with the occurrence of non-cystic fibrosis bronchiectasis (NCFB). There are few data on NCFB and adverse events from immunosuppressive or biological response modifier therapy in patients with rheumatoid arthritis (RA) or IBD and NCFB. We identified 37 patients ...
Nam Chang-Wook - - 2011
This study was aimed at investigating whether a fractional flow reserve (FFR)-guided SYNTAX score (SS), termed "functional SYNTAX score" (FSS), would predict clinical outcome better than the classic SS in patients with multivessel coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). The SS is a purely anatomic score based ...
Barleben Andrew - - 2011
: In a previous retrospective study, we demonstrated that pelvic radiographs (PXRs) in the evaluation of blunt trauma patients undergoing abdominal computed tomographic (CT) scanning have limited utility in the absence of hemodynamic instability and significant physical findings. The purpose of this study was to prospectively validate an algorithm defining ...
Dou Yanna - - 2011
Background: We proposed a new method to estimate dry weight (DW) using single frequency bioimpedance. Methods: We hypothesized that the change in whole body resistance at 50 kHz (R(50)) was proportional to the ultrafiltration volume (UFV) during a hemodialysis (HD) session. When the targeted resistance estimated in healthy subjects was ...
Karimi M - - 2011
Summary.  We aimed to evaluate the effect of regular prophylaxis with a Factor X (FX) concentrate for patients with severe FXD in Iran and to assess the correlation of the genotype and phenotype in these patients. Ten patients with severe FXD (FX activity <1%) were enrolled and characterized during 2010-2011. ...
Chen Jin-Bor - - 2011
Aim.  SBR759 is a calcium-free, polymeric, iron(III)-based oral phosphate binder, in development for the treatment of hyperphosphatemia. This study compared the efficacy and safety of SBR759 with sevelamer hydrochloride in chronic kidney dialysis patients on hemodialysis. Methods.  Japanese and Taiwanese hyperphosphatemic patients who were on hemodialysis (n = 203) received ...
van Lümig P P M - - 2011
Guidelines concerning biological treatment of patients with psoriasis recommend different pretreatment and monitoring laboratory panels in variable frequencies to monitor treatment. To investigate the relevance of laboratory investigations in monitoring patients with psoriasis on etanercept or adalimumab. A prospective cohort study over 5 years was conducted in all consecutive patients ...
Besouw Martine T P - - 2011
OBJECTIVE: To report new adverse effects of cysteamine. STUDY DESIGN: Detailed clinical information was obtained from the patients' physicians. RESULTS: New adverse events were reported in 8 of 550 patients with cystinosis treated with cysteamine in Europe during the last 5 years. Detailed clinical information was not available for 2 ...
Sun Pei-Yu - - 2011
ABSTRACT BACKGROUND: A prolonged QRS duration (≥120 ms) predicts outcomes in patients with left heart failure, but the impact in idiopathic pulmonary arterial hypertension (IPAH) and right heart failure is unknown. We assessed the prognostic value of a prolonged electrocardiographic (ECG) QRS duration in patients with IPAH in China. METHODS: ...
Guzelkucuk U - - 2012
Case report. To report a case of paraplegia with limb edema caused by pregabalin. Turkish Armed Forces Rehabilitation Center, Ankara, Turkey. A 40-year-old male patient with T11 paraplegia had the complaint of swelling in both the lower limbs. He had been given pregabalin because of the neuropathic pain in both ...
Savitz Sean I - - 2011
Cellular therapy is an investigational approach for stroke. Mononuclear cells (MNCs) from the bone marrow reduce neurological deficits in animal stroke models. We determined if autologous MNC infusion was feasible and safe in patients with ischemic stroke. We conducted an open-label prospective study of a bone marrow harvest followed by ...
Sipahi Ilke - - 2011
Cardiac resynchronization therapy (CRT) is effective in reducing clinical events in patients with heart failure and prolonged QRS interval. Studies using surrogate measures and subgroup analysis of large trials suggest that only patients with severely prolonged QRS benefit from CRT. Our objective was to determine whether the effect of CRT ...
Malm J - - 2011
Malm J, Sundström N, Cesarini KG, Edsbagge M, Kristensen B, Leijon G, Eklund A. Implementation of a new CSF dynamic device: a multicenter feasibility study in 562 patients. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2011.01533.x. © 2011 John Wiley & Sons A/S. Objectives -  The cerebrospinal fluid (CSF) infusion test is frequently used ...
Lainscak Mitja M Division of Cardiology, University Clinic Golnik, Golnik, Slovenia. - - 2013
Self-rated health (SRH) predicts outcome in patients with heart failure. Beta-blockers are known to improve health-related quality of life and reduce mortality in such patients. We aimed to evaluate the relation between SRH and adverse events during titration of beta-blockers in elderly patients with heart failure. The cardiac insufficiency bisoprolol ...
Thomas George - - 2011
Atrial fibrillation (AF) is a large public health problem that affects about 1% of the population in the United States. It confers an increased risk for stroke and thromboembolism, but the stroke risk is not equal in all patients. Further refinement in stratifying stroke risk in patients with AF will ...
Behm Martin O - - 2011
(Headache 2011;51:954-960) Objective.- The primary purpose of the study was to explore the safety and tolerability of telcagepant in patients with stable coronary artery disease. Background.- Triptans are effective acute anti-migraine drugs whose vasoconstrictive effects limit their use in patients at risk for adverse cardiovascular events. Telcagepant, a calcitonin gene-related ...
Fitzpatrick Amanda M AM Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, - - 2011
Human and animal studies on antibody-mediated neuropathy implicate complement in pathogenesis. In animal models complement inhibition is therapeutically beneficial. The monoclonal antibody, eculizumab (Soliris™, Alexion Pharmaceuticals, Cheshire, CT), prevents cleavage of C5 and thus inhibits terminal complement activation. In an open label study, 13 multifocal motor neuropathy patients received eculizumab ...
Karmazyn Boaz - - 2011
BACKGROUND: Caliceal diverticulum (CD) is uncommon in children. As compared to adults, most children with CD are symptomatic. Common complications include stone formation and infection. Correct diagnosis of CD is important for guiding management. OBJECTIVE: To identify imaging findings at diagnosis and follow-up in pediatric patients with CD. MATERIALS AND ...
González-Pérez Ruperto - - 2011
The nasal provocation test (NPT) with lysine aspirin is a useful tool in the diagnosis of aspirin-exacerbated respiratory disease (AERD), previously reffered to as Samter's disease. The aim of the present study focuses on methodological interventions to show the usefulness of the NPT with lysine aspirin in differentiating AERD patients ...
Escoté Xavier - - 2011
Little information is available with respect to the involvement of resistin in lipodystrophy and metabolic disturbances in HIV-1-infected patients treated with combination antiretroviral therapy (cART). We determined whether the resistin (rest) -420C>G single-nucleotide polymorphism and plasma resistin are associated with the development of lipodystrophy and metabolic disturbances in HIV-1-infected patients ...
Hirao Makoto - - 2011
Two cases of subcutaneous soft tissue infection in 30 RA patients treated with tocilizumab are reported. In both patients, local redness, swelling, and heat were observed around the affected site. WBC spikes and such local findings were suggested to be clinically useful for the early detection of low-grade subcutaneous infection ...
Budano Carlo - - 2011
Contrast-induced acute kidney injury (CIAKI) is a frequent complication after infusion of contrast media in patients undergoing percutaneous coronary intervention. A wide range of CIAKI rates occurs after intervention between 3% and 30%, depending on the definition. The aim of this study was to identify which methodology was more effective ...
Tsai Yi-Chan - - 2011
OBJECTIVE: To study possible associations between extended mannose-binding lectin (MBL) expression genotypes and clinical manifestations and infections in children with systemic lupus erythematosus (SLE). METHODS: Clinical and laboratory variables for a cohort of 125 patients with pediatric-onset SLE were obtained by clinical examinations and chart reviews. Controls were 137 age-matched ...
Belizna C - - 2011
INTRODUCTION: Cryofibrinogenemia may be essential, or secondary to diseases such as neoplasia, infection, thrombosis, and collagen vascular diseases. In a previous study, we reported the occurrence of neoplasia in some essential cryofibrinogenemia patients after a short period of follow-up. PURPOSE: We performed a prospective multi-center 5-year follow-up study in essential ...
Diaz R R - - 2011
In this investigation, we study the relation between chronic inflammation of the tonsils, clinical features, and the presence of biofilms in the crypts in patients presenting with obstructive hypertrophy and recurrent upper airway pathology. Thirty-six patients who needed to undergo a tonsillectomy for obstructive reasons (aged 1 to 6 years), among ...
Da Silva Cristiane França - - 2011
Objectives As part of a search for new therapeutic opportunities to treat chagasic patients, in vitro efficacy studies were performed to characterize the activity of five novel arylimidamides (AIAs) against Trypanosoma cruzi. Methods The trypanocidal effect against T. cruzi was evaluated by light microscopy through the determination of IC(50) values. ...
Barrientos Alejandro - - 2011
Human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) are oncogenic retroviruses linked etiologically to human diseases. In Chile, these viruses have been studied in ethnic populations, or patients diagnosed clinically with HTLV-1 associated myelopathy/tropical spastic paraparesis, but have not been studied in patients with malignant hematological diseases. The aim ...
- - 2011
Spironolactone is a potassium-sparing diuretic marketed since the 1960s that is known to cause the same adverse effects as other diuretics as well as some effects of its own, such as hyperkalaemia, gynaecomastia and menstrual disturbances. A cohort study and 2 case-control studies concurred to show an approximately twofold, dose-dependent ...
Soon Elaine E Papworth Hospital NHS Trust, Papworth Everard, Cambridgeshire, - - 2011
N-terminal pro B-type natriuretic peptide (NT-proBNP) is a product of cleavage of the cardiac prohormone pro B-type natriuretic peptide into its active form. It has proven to be a useful biomarker in left heart failure. However, studies examining the utility of serial measurements of NT-proBNP in pulmonary arterial hypertension (PAH) ...
Knudsen Jane B - - 2011
Abstract Objective. To investigate if earlier reported retrospectively derived criteria for predicting absence of infective endocarditis (IE) on transthoracic echocardiography could be prospectively confirmed or improved with transoesophageal echocardiography (TOE). Design. Prospective analysis of the relationship between predefined clinical IE features and findings on TOE in 708 IE suspected patients. ...
Tang W H Wilson - - 2011
Congest Heart Fail. 2011;17:105-109. (©) 2011 Wiley Periodicals, Inc. Various inflammatory biomarkers predict long-term outcomes in patients with acute and chronic heart failure (HF). Their relative contributions when measured in combination have not been evaluated. The authors measured both plasma levels of high-sensitivity C-reactive protein (hsCRP) and myeloperoxidase (MPO) in ...
Niebuhr Margarete - - 2011
  In many patients with atopic dermatitis (AD), the disease is complicated by their enhanced susceptibility to bacterial skin infections, especially with Staphylococcus aureus (S. aureus). Resistance to bacterial skin infections, e.g. S. aureus, is based on the function of intact innate immune mechanisms in the epidermis, mainly provided by keratinocytes. Toll-like ...
Li Yue Guo - - 2011
Background/Aims. A lack of sensitive and specific biomarkers is a major reason for the high rate of primary hepatocellular carcinoma (HCC)-related mortality. The aim of this study was to investigate potential proteomic biomarkers specific for HCC. Methods. Total serum samples were collected with informed consent from 80 HCC patients with ...
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