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Mócsai G - - 2013
Filaggrin (FLG) deficiency is a well-known predisposing factor for the development of atopic dermatitis (AD). Decreased FLG expression can be the result of haploinsufficiency or severe inflammation, which can cause acquired FLG alterations. FLG mutations are related to several clinical and laboratory parameters of AD; however, some recent data seem ...
Brouwers H Bart HB Center for Human Genetic Research-Rosand Lab, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, CPZN-6818, Boston, MA 02114, USA. - - 2012
Hematoma expansion after acute intracerebral hemorrhage occurs most frequently in patients presenting within 3 h of symptom onset. However, the majority of patients present outside this window or with an unknown onset time. We investigated the prevalence of hematoma expansion in these patients and assessed the accuracy of the CT ...
Aller R - - 2012
Background: Considering the evidence that endogenous cannabinoid system plays a role in metabolic aspects of body weight and metabolic syndrome components such as non alcoholic fatty liver disease (NAFLD). The aim of our study was to investigate the influence of this polymorphism on insulin resistance, liver histological changes, anthropometric parameters ...
Nguyen Hl - - 2012
OBJECTIVES: The mechanism of raltegravir (RAL)-resistant evolutions has not already been elucidated. Because the emergence of RAL resistance is usually initiated by the N155H mutant, we assessed the role of minor N155H-mutated variants in circulating RNA and archived DNA in five heavily treated patients experiencing long-term RAL therapy failure and ...
Schultheiss Caroline - - 2012
ABSTRACT: INTRODUCTION: Liver failure patients might be at risk for citrate accumulation during continuous venovenous hemodialysis (CVVHD) with regional citrate anticoagulation. The aim of this study was to investigate the predictive capability of baseline liver function parameters regarding citrate accumulation expressed as an increase in the calcium total/calcium ionized (Catot/Caion) ...
Knyazeva Maria G - - 2012
Alzheimer's disease (AD) disrupts functional connectivity in distributed cortical networks. We analyzed changes in the S-estimator, a measure of multivariate intraregional synchronization, in electroencephalogram (EEG) source space in 15 mild AD patients versus 15 age-matched controls to evaluate its potential as a marker of AD progression. All participants underwent 2 ...
Bacci Elena - - 2012
SUMMARY AT A GLANCE: In 60% of patients with non-eosinophilic asthma who received salmeterol monotherapy, low sputum eosinophils persisted over six months. However, transient sputum eosinophilia was observed over time in 40% of patients. This was not associated with clinical deterioration, probably due to suppression of symptoms by salmeterol. ABSTRACT: ...
Roberts Brian W - - 2012
OBJECTIVE: Clinical trials of therapeutic hypothermia (TH) after cardiac arrest excluded patients with persistent hemodynamic instability after return of spontaneous circulation (ROSC), and thus equipoise may exist regarding use of TH in these patients. Our objective was to determine if TH is associated with worsening hemodynamic instability among patients who ...
Flint Alexander C - - 2012
BACKGROUND AND PURPOSE: Patients with cryptogenic ischemic stroke may have undetected paroxysmal atrial fibrillation (PAF). We established the Stroke and Monitoring for PAF in Real Time (SMART) Registry to determine the yield of 30-day outpatient PAF monitoring in cryptogenic ischemic stroke. METHODS: The SMART Registry was a 3-year, prospective multicenter ...
Di Biase Luigi - - 2012
This study investigated the left atrial appendage (LAA) by computed tomography (CT) and magnetic resonance imaging (MRI) to categorize different LAA morphologies and to correlate the morphology with the history of stroke/transient ischemic attack (TIA). LAA represents one of the major sources of cardiac thrombus formation responsible for TIA/stroke in ...
Lee Sang Il - - 2012
OBJECTIVE: To evaluate the timing of the swallowing process and the effect of bolus viscosity on swallowing. DESIGN: Prospective observational study. SETTING: General teaching hospital, rehabilitation unit PARTICIPANTS: We enrolled 82 dysphagic patients in a videofluoroscopic swallowing study (VFSS) from Jan 13, 2009 to Oct 22, 2009. Based on VFSS ...
McKenzie Patrick - - 2012
Cerebrovascular accident or stroke is a devastating neurologic event that can have both short and long term urologic complications. The purpose of this article is to provide an up-to-date review of the incidence and causes of voiding dysfunction after stroke, the evaluation of voiding dysfunction in patients after stroke, and ...
Wuehr M - - 2012
OBJECTIVE: This study investigated the influence of impaired cerebellar locomotion function on the magnitude and structure of stride-to-stride fluctuations in the walking pattern. On the basis of studies reporting a dependency of variability magnitude and structure on the walking speed, we hypothesized that patients with cerebellar ataxia (CA) would show ...
Becker Andreas - - 2012
BACKGROUND:: During external ventricular drainage (EVD)-weaning, cranial computed tomography (cCT) is necessary to evaluate ventricle width. Because intra-hospital transfer of critically ill patients is associated with higher mortality, bedside techniques are necessary to evaluate ventricle width. Transcranial sonography is able to show the ventricles in patients with sufficient temporal acoustic ...
Chuang Han-Yu - - 2012
The clinical course of patients with chronic lymphocytic leukemia (CLL) is heterogeneous. Several prognostic factors have been identified that can stratify patients into groups that differ in their relative tendency for disease progression and/or survival. Here, we pursued a subnetwork-based analysis of gene expression profiles to discriminate between groups of ...
Saez Jesús - - 2012
The aim of this study was to determine the diagnostic usefulness of quantification of the H. pylori genome in detection of infection in patients with upper gastrointestinal bleeding (UGB). A total of 158 consecutive patients with digestive disorders, 80 of whom had clinical presentation of UGB, were studied. The number ...
Shah Asad A - - 2012
Mitral valve prolapse may involve 1 leaflet or 2 leaflets, yet management guidelines do not differentiate posterior leaflet (PML) from bileaflet (BML) prolapse. We hypothesized that patients with BML have a prolonged natural history with more severe atrial and ventricular enlargement but less severe mitral regurgitation (MR) compared to patients ...
Jeon Seong Ran - - 2012
BACKGROUND & AIM: We performed a retrospective study to investigate changes, between different time periods, in the indications, diagnostic yield, and clinical impact of double-balloon enteroscopy (DBE). METHODS: We analyzed records from the database at Soonchunhyang University College of Medicine from all patients undergoing DBE between September 2004 and May ...
Lieberman Abraham - - 2012
Abstract Although gait and balance difficulties often occur together in Parkinson's disease (PD) patients, it is believed that they are actually two separate symptoms. However, there are no simple tests to distinguish them. We have developed the self-administered Barrow Neurological Institute (BNI) question to distinguish between gait and balance issues ...
Luesebrink Ulrich - - 2012
BACKGROUND: RF ablation for cavotricuspid isthmus (CTI) dependent flutter is an established therapy. Right atrial hypertrophy and enlargement are associated with the occurrence of cavotricuspid isthmus dependent flutter. Therefore, patients with pulmonary hypertension (PAH) are prone to atrial arrhythmias like cavotricuspid isthmus dependent flutter. However, the influence of PAH on ...
Polzikov Mikhail - - 2012
To evaluate the level of ribosomal RNA (rRNA) in cumulus cells (CCs) from women with polycystic ovary syndrome (PCOS) undergoing ICSI. The study population included three healthy oocyte donors (control) and three patients with PCOS. RNA expression in CCs was assessed using quantitative real-time PCR assay to measure the pre-rRNA ...
Ferraz Júnior Antônio Márcio Lima - - 2012
OBJECTIVE: The objective of this study was to assess the presence of temporomandibular disorder (TMD) in patients with juvenile idiopathic arthritis (JIA), and correlate with tomographic findings and clinical aspects. STUDY DESIGN: Fifteen patients with JIA were evaluated by means of RDC/TMD, and submitted to a cone beam computerized tomography ...
Cellai Anna Paola - - 2012
The pathogenesis of retinal vein occlusion (RVO), has not been well understood. Recent data have shown the efficacy of an anticoagulant therapy with LMWHs in the treatment of acute RVO suggesting the presence of a hypercoagulable state in these patients. New global tests for detection of hypercoagulability and hypofibrinolysis have ...
Hedsund Caroline - - 2012
Abstract Objective. Patients with cystic fibrosis (CF) often suffer from gastrointestinal (GI) dysfunction including obstructive symptoms, malabsorption and pain, but the underlying pathophysiology remains obscure. Aim. To compare GI motility and transit times in CF patients and healthy controls. Material and methods. Ten CF patients (five women, median age 23) ...
Frazzitta Giuseppe - - 2012
It has been hypothesized that freezing of gait (FOG) in parkinsonian patients (PD) might be triggered by a breakdown in the normal symmetry of gait. In this study, we evaluated the relationship between asymmetry of gait and FOG and the effects of intensive treadmill treatment on asymmetry. We studied 30 ...
Nilla Olavarria Viviana - - 2012
Variations in human T cell lymphotropic virus type 1 (HTLV-1) proviral load (PVL) in infected individuals over time are not well understood. To evaluate the evolution of proviral load in asymptomatic individuals and HAM/TSP patients in order to help determine periodicity for measuring proviral load. A group of 104 HTLV-1 ...
Schubert Gerrit Alexander - - 2012
BACKGROUND:: Acute neurological deficits after SAH correlate with outcome, and a phase of acute hypoperfusion has been characterized recently. ICG videography is an established intraoperative imaging technique with important descriptive potential. OBJECTIVE:: To analyze whether ICG can be used to analyze and confirm perfusion changes early after SAH. METHODS:: We ...
Fisher Derek J - - 2012
Auditory verbal hallucinations (AHs), or hearing 'voices', are one of the hallmark symptoms of patients with schizophrenia. The primary objective of this study was to compare hallucinating schizophrenia patients with respect to differences in deviance detection, as indexed by the auditory mismatch negativity (MMN). Patients were recruited during an acute ...
Dedic Svetlana I Kostic - - 2012
Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative motor neuron disease in adults, whose relentless course leads to death within 2?5 years, generally due to respiratory failure. Apart from the age and site of onset, no other factors have consistently demonstrated to be related to the ALS ...
Finke Carsten - - 2012
Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Its pathophysiology remains poorly understood and objective measures to quantify fatigue are unavailable to date. To investigate whether analysis of ocular motor movements can provide diagnostic information in MS patients with fatigue, 37 MS patients (21 ...
Voss Andreas - - 2012
The objectives of this study were to introduce a new type of heart-rate variability analysis improving risk stratification in patients with idiopathic dilated cardiomyopathy (DCM) and to provide additional information about impaired heart beat generation in these patients. Beat-to-beat intervals (BBI) of 30-min ECGs recorded from 91 DCM patients and ...
Nima Jamshidi - - 2012
The aim of this study was examining the effect of human factors such as plantar friction, contact period time, and impulse on shoe-sole trituration of drop foot patients. Twenty-five patients with drop foot and twenty normal subjects were recruited in the study. The force plate and its related software's recorded ...
Soshitova Natalia P - - 2012
Inflammation in sepsis is associated with hypercoagulation that may lead to thrombosis and disseminated intravascular coagulation. Conventional diagnostic assays are poorly sensitive to procoagulant changes in sepsis. Objectives of the article is to study changes in hemostatic state of septic patients using spatial clot growth assay (currently being developed under ...
Tian-Jun Li - - 2012
Objective To investigate the time to disappearance of thyroglobulin antibodies (TgAb) and its influencing factors in papillary thyroid carcinoma (PTC) patients with positive TgAb after radioiodine ((131)I) ablation. Methods We retrospectively analyzed the clinical data of 64 PTC patients who had undergone a total thyroidectomy and subsequent (131)I therapy. Patients ...
Kirwan John R - - 2012
Even in patients with apparently well-controlled RA, debilitating symptoms such as morning stiffness, fatigue and pain may occur. The key to controlling these symptoms may be in understanding their pathophysiology, which is probably most advanced for morning stiffness. Nocturnal plasma levels of the pro-inflammatory cytokine IL-6 are elevated in patients ...
Adrover Raúl - - 2012
Hepatic encephalopathy is a serious neuropsychiatric complication in advanced liver disease. The affected patients exhibit alterations in psychomotor and intellectual functions. The aims of this study were to identif the set ofnormal values for the number connection tests (NCT-A and NCT-B) in a population of volunteers without liver disease, to ...
Lyden Patrick - - 2012
Therapeutic hypothermia is a promising neuroprotective therapy with multiple mechanisms of action. We demonstrated the feasibility of thrombolysis combined with endovascular hypothermia, but not all patients achieved effective cooling. We sought to identify the factors that determined effective cooling. In 26 patients who underwent endovascular hypothermia, we computed four measures ...
Ganzel C - - 2012
HL and NHL have traditionally been considered as two distinct entities. However, there are rare reports of patients that over time develop both diseases. It remains unresolved whether the origin of the two diseases is from the same clone. In this study we attempted to retrospectively investigate the clinical and ...
Homnick Adena - - 2012
INTRODUCTION: Patients with mild traumatic brain injury (MTBI) and intracranial haemorrhage (ICH) are hospitalized and monitored for progression of injury. The timeframe for ICH progression is unknown, and so the optimal duration and location of observation are generally discretionary. The goal of this study was to examine the temporal course ...
Nacar Alper Bu─čra - - 2012
Background: Prolonged atrial conduction time measured by tissue Doppler imaging (TDI) has been associated with increased risk of atrial fibrillation. We aimed to evaluate the effect of subclinical hyperthyroidism (SH) and antithyroid treatment on atrial conduction time. Methods: A total of 30 patients with SH (26 females; mean age 34.8 ...
Kim Young Woo - - 2012
Nonaneurysmal subarachnoid hemorrhage (NA-SAH) constitutes a heterogeneous group of patients, both perimesencephalic (PMN-SAH) and non-perimesencephalic (nPMN-SAH). Despite many reports and case series, the etiology of NA-SAH remains uncertain. The differences in clinical course and outcome between PMN-SAH and nPMN-SAH are evident and have to be taken into consideration at the ...
Picard Hernàn - - 2012
Many motor and cognitive alterations in schizophrenia suggest the involvement of the cerebellum. Neurological soft signs (NSS) are frequent in patients with schizophrenia and reductions in cerebellar volume have been associated with high NSS scores. In this study, we tested saccadic adaptation, a well-characterised oculomotor paradigm involving the cerebellum, in ...
Viersen Va - - 2012
AIM OF THE STUDY: : This study investigated the incidence of hyperfibrinolysis upon emergency department (ED) admission in patients with out of hospital cardiac arrest (OHCA), and the association of the degree of hyperfibrinolysis with markers of hypoperfusion. METHODS: From 30 OHCA patients, cardiopulmonary resuscitation (CPR) time, pH, base excess ...
Pongpit Jamrus - - 2012
Viper bites cause consumptive coagulopathy resulting in hypofibrinogenaemia. Whole-blood clotting time is a standard test used to assess bleeding risk. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are better standardised assays that are widely available, but their diagnostic accuracy in viper bites remains unknown. Adult patients presumed bitten ...
Arreguín Reyes Roberto - - 2012
INTRODUCTION: Questionnaires to evaluate hand function are variable in the number of items, domains and diseases in which they had been previously used. OBJECTIVES: a) To translate to Spanish and validate the m-SACRAH and AUSCAN questionnaires; b) to do a transcultural adaptation of DASHe, previously validated in Spain), and c) ...
Aronow Mary E - - 2012
OBJECTIVE: To evaluate genotype/phenotype correlations in individuals with astrocytic hamartoma (AH) and retinal achromic patch (AP) in the setting of tuberous sclerosis complex (TSC). DESIGN: Retrospective consecutive case series. PARTICIPANTS: A total of 132 patients enrolled in the Cleveland Clinic Foundation Tuberous Sclerosis Program (CCF-TSCP) and 907 patients from the ...
Peretz Asaf - - 2012
Abstract Background and aim: Variation in the prevalence of various types of gastric polyps worldwide may reflect different etiologies. Here, the authors report the dynamic changes in histological distribution of gastric polyps over time and by ethnicity for individuals who underwent gastroscopies between 1994 and 2009 at two hospitals in ...
Fujiwara Mika - - 2012
ABSTRACT:: Primary cutaneous B-cell lymphomas (PCBCL) are rare. Marginal zone lymphomas and follicle center lymphomas (FCL) represent a majority of these cases, and a significant number of cases present with multiple lesions. It is unclear whether multiple lesions in PCBCL represent dissemination of a single clone or multiple new primary ...
Sekercioglu Nigar - - 2012
PURPOSE: The optimal target for glycated hemoglobin (HbA1c) has not been well defined in peritoneal dialysis (PD) patients with diabetes mellitus. METHODS: The objective of our study was to examine the predictive value of predialysis and time-averaged follow-up HbA1c values on technique and patient survival in diabetic PD patients treated ...
Ago Rika - - 2012
BACKGROUND: When diagnosing hypertension (HT) it is essential to determine not only the level of raised blood pressure (BP), but also how the condition relates to organ damage. The best time to measure BP for diagnosing HT in patients on hemodialysis (HD) remains unclear. METHODS: A total of 100 HD ...
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