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Wu Chi-Lin CL Department of Neurology, Chang Gung University, Taipei, - - 2014
Introduction: A case series of acute intermittent porphyria (AIP) is described which focuses on the clinical course of the disease with regard to neurological manifestations of the peripheral nervous system. Methods: Eight patients were diagnosed with AIP on the basis of characteristic clinical findings, erythrocyte porphobilinogendeaminase activity, neuropathic patterns, serial ...
Salvarani Carlo C Unità Operativa di Reumatologia, Azienda Ospedaliera ASMN, IRCCS di Reggio Emilia, Italy. - - 2014
Primary central nervous system vasculitis (PCNSV) is an uncommon condition that affects the brain and the spinal cord. It is heterogeneous in presenting characteristics and outcomes. We report a patient with a catastrophic rapidly progressive course refractory to intensive treatment with pulses of methylprednisolone and iv cyclophosphamide. The condition rapidly ...
Cabalar Murat M Dr. Murat Cabalar, Department of Neurology, Bakirkoy Dr. Sadi Konuk Research & Training Hospital, Istanbul, - - 2014
Objectives: The aim of this study was to evaluate neurological and neurophysiological features of leprosy. Methods: Seventy seven hospitalized leprosy patients (52 male, 25 female) were examined neurological and neurophysiologically between 2010 and 2012. Standard procedures were performed for evaluating sensory and motor conduction studies to all patients. Motor studies ...
Mahler Donald A DA Section of Pulmonary & Critical Care Medicine Geisel School of Medicine at Dartmouth, Hanover, NH. Electronic address: - - 2014
The objective of this study was to investigate whether substance P, an excitatory neuropeptide, modulates the perception of breathlessness by administering aprepitant, a selective antagonist that blocks neurokinin (NK)-1 receptor signaling. Individual targeted resistive load breathing (RLB) was used to provoke breathlessness. In Study 1, sixteen patients (age, 70±6 years) ...
Afshar Maryam M Department of Pediatrics, Children's Hospital & Research Center Oakland, Oakland California. Electronic address: - - 2014
The pathogenesis of methotrexate central nervous system toxicity is multifactorial, but it is likely related to central nervous system folate homeostasis. The use of folinate rescue has been described to decrease toxicity in patients who had received intrathecal methotrexate. It has also been described in previous studies that there is ...
Kalita Jayantee J Department of Neurology, Sanjay Gandhi Post Graduate Medical Sciences, Lucknow, - - 2014
There is a paucity of large studies evaluating the subtypes of GBS and their outcome from South East Asia. We report cliniconeurophysiological subtypes of GBS and their correlation with triggering events and 3-month outcome from Northern India. 328 consecutive patients with GBS were clinically evaluated, including their triggers, severity, autonomic ...
Bérubé Maxime D MD Department of Neurology, Centre Hospitalier de l'Université de Montréal, and Faculty of Medicine, Université de Montréal, Montreal, QC, - - 2014
Henoch-Shönlein purpura (HSP) is a systemic small vessel vasculitis. Most patients present during childhood. The characteristic association of purpura, arthralgia, abdominal pain, and nephritis reflects the predominant distribution of vasculitis. Headaches and mild behavioral changes suggest CNS involvement in one-third of HSP patients. Salient central nervous system (CNS) manifestations are ...
Choi Jeong-Yoon JY Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, South Korea. Electronic address: - - 2013
Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central ...
Roshanzamir Sharareh - - 2013
Sensory, motor, and autonomic neuropathy has been reported after electrical injury. Besides subclinical involvement of the sympathetic nervous system during the 1st year post injury, late clinical manifestations of this involvement have been reported sporadically. This study was designed to investigate how the clinical and electrodiagnostic manifestations of sympathetic involvement ...
Krstacić Antonija - - 2013
Spinal cord injury may cause loss of cardiovascular reflexes mediated by sympathetic drive due to interruption in the supraspinal control of spinal sympathetic motoneurons. The aim of this study was to analyze sympathovagal balance after acute spinal cord injury demonstrated by linear measures in time and frequency domain of heart ...
Yi Ho Jun HJ Department of Neurosurgery, Dongtan Sacred Heart Hospital, College of Medicine, Hallym University, Hwaseong, - - 2013
A 35-year-old man presented with simultaneous multiple intracranial hematomas in the right cerebellar dentate nucleus and left basal ganglia. The hematomas were visible by computed tomography performed within two hours of the patient's arrival. The initial computed tomography showed acute hemorrhage in the left basal ganglia and dentate nucleus in ...
Fakhran Saeed - - 2013
To determine if nerve root sleeve diverticula or CSF leakage correlate with post-dural puncture headache (PDPH). A total of 781 lumbar and 408 cervical post-myelogram CTs were reviewed using a total diverticulum and leakage (TDL) score: 1, nerve root sleeve diverticulum not beyond the lateral vertebral body; 2, diverticulum beyond ...
Jovanovic Ankica A Department of Pediatric Hematology, Mother and Child Health Institute, Medical Faculty, University of Belgrade, Serbia; Department of Neurology, Mother and Child Health Institute, Medical Faculty, University of Belgrade, Serbia; Department of Radiology, Mother and Child Health Institute, Medical Faculty, University of Belgrade, Serbia; Department of Immunology, Mother and Child Health Institute, Medical Faculty, University of Belgrade, - - 2013
Hemophagocytic lymphohistiocytosis is a rare multisystem disorder characterized by proliferation and diffuse infiltration multiple organs with histiocytes, including the central nervous system. Thirty children diagnosed with hemophagocytic lymphohistiocytosis between 1997 and 2010 were reviewed and analyzed. Central nervous system disease involvement was defined as the presence of neurological symptoms and ...
Kandratavicius Ludmyla - - 2013
Despite the strong association between epilepsy and psychiatric comorbidities, data on clinicopathologic correlations are scant. We previously reported differential mossy fiber sprouting (MFS) in mesial temporal lobe epilepsy (MTLE) patients with psychosis (MTLE + P) and major depression (MTLE + D). Because neurotrophins (NTs) can promote MFS, here, we investigated ...
Deogaonkar Milind - - 2014
Multiple studies have shown proved efficacy of spinal cord stimulation (SCS) in peripheral vascular disease (PVD). The exact mechanism by which SCS acts in the treatment of PVD is not completely understood, and may include stimulating the release of nitric oxide, modulation of the sympathetic nervous system, or modulation of ...
Tekatas Aslan - - 2013
The involvement of the autonomic nervous system is less common than that of the central and peripheral nervous system in systemic lupus erythematosus (SLE) patients. However, its involvement can negatively affect the quality of life of the patient and cause life-threatening situations. In this study, autonomic function was evaluated in ...
Han Eun Young - - 2013
Abstract Purpose: The objective was to determine whether the abnormal finding of somatosensory evoked potentials (SEPs) associated with the development of type I complex regional pain syndrome (CRPS) after stroke. Methods: This was a retrospective study conducted from January, 2003, to December, 2007. Seventy patients were confirmed as CRPS type ...
Anderson William D WD 3rd University of South Carolina School of Medicine, Columbia , SC, - - 2013
In the absence of acute abdominal pain, significant headache, or recent initiation of certain medications, acute nausea and vomiting is usually the result of self-limited gastrointestinal infections. Nausea and vomiting is also a common adverse effect of radiation therapy, chemotherapy, and surgical anesthesia. Other potential diagnoses include endocrine conditions (including ...
Ohn Suk Hoon - - 2013
The aim of this study was to investigate spinal cord injury (SCI) on the basis of diffusion tensor imaging (DTI) in patients with high-voltage electrical injury. We recruited eight high-voltage electrical injury patients and eight healthy subjects matched for age and sex. DTI and central motor conduction time were acquired ...
Schebesch Karl-Michael - - 2013
In the human brain, the potent vasoconstrictive neuropeptide Y (NPY) is abundantly expressed. Neuropeptide Y, which is stored in perivascular nerve fibers of the cerebral arteries, regulates the cerebral vascular diameter as well as cerebral blood flow. However, the role of NPY in the pathogenesis of cerebral vasospasm (CV) related ...
Bauer P R - - 2013
Headache and epilepsy often co-occur. Epidemiologic studies conducted in the past few years reinforce the notion of a bi-directional association between migraine and epilepsy. Data on an association between headache (in general) and epilepsy, however, are less clear. Peri-ictal headache often presents with migraine-like symptoms and can be severe. A ...
Kuo P - - 2013
Transient lower esophageal sphincter relaxation (TLESR) is a vagally mediated reflex that occurs most frequently after a meal. Cardiac vagal tone (CVT) decreases after a meal, and correlates with changes in gastric electrical activity. Furthermore, decreased CVT has been reported in patients with gastroesophageal reflux disease. We therefore aimed to ...
Yanik Tulin - - 2013
The use of antipsychotic drugs has started a new era in the treatment of psychotic disorders. Nevertheless, they cause complications in the long-term treatment, which is mainly weight gain. In this study, we investigated circulating levels of hypothalamic neuropeptides, which are related to appetite regulation, neuropeptide Y (NPY), α-melanocyte-stimulating hormone ...
Ieda Masa - - 2013
Several researches indicate that autonomic nervous system (ANS) dysfunction in patients with schizophrenia. Recently, salivary alpha-amylase (sAA) has been employed as a useful marker for ANS function. We investigated the extent of ANS dysfunction by measuring sAA and heart rate variability (HRV) of 25 patients with schizophrenia compared with controls. ...
Abuhandan M - - 2013
Aim. This study aimed to evaluate the neuropeptide Y values of patients with subacute sclerosing panencephalitis. Materials and Methods. The study comprised 38 patients diagnosed with subacute sclerosing panencephalitis at our clinic, who were being routinely followed-up, together with a control group of 36. Using the Risk and Haddad classification ...
de Mendivil Ana Ortiz - - 2013
Ischemic brainstem strokes constitute 10% of all ischemic brain strokes. Hemorrhagic complications are associated with an especially poor prognosis. Associated symptomatology includes vertigo, cranial nerve symptoms, and crossed or uncrossed corticospinal tract findings. Advanced neuroimaging techniques have become essential in the decision-making process of brainstem stroke management and may provide ...
Emad Reza - - 2013
Sympathetic skin response (SSR) is a test for evaluation of the sympathetic sweat gland pathways, and it has been used to study the central sympathetic pathways in spinal cord injury (SCI). This study aimed to assess the autonomic pathways according to normal or abnormal SSR in urinary incontinence patients due ...
Altunrende Burcu - - 2013
Although the role of autonomic nervous system in seborrheic dermatitis (SD) is still unclear, seborrhea is sometimes accepted as a sign of autonomic dysfunction in several nervous system diseases. Therefore, we aimed to investigate the sympathetic nervous system (SNS) activity in SD by recording sympathetic skin responses (SSR) from the ...
Mini Sne Ana - - 2013
ABSTRACT: The objective of this study was to present a systematic review of the central nervous system (CNS) types of anomalies and to consider the possibility to include CNS anomalies in Incontinentia pigmenti (IP) criteria. The analyzed literature data from 1,393 IP cases were from the period 1993--2012. CNS anomalies ...
Schytz Henrik W - - 2013
BackgroundHigh frequency (HF) stimulation of the sphenopalatine ganglion (SPG) is an emerging abortive treatment for cluster headache (CH) attacks. HF SPG stimulation is thought to exert its effect by physiologically blocking parasympathetic outflow. We hypothesized that low frequency (LF) SPG stimulation may activate the SPG, causing increased parasympathetic outflow and ...
Liou Li-Min - - 2013
This study aimed to investigate which cerebral cortices are involved in the central autonomic network and how they are linked to the peripheral (cardiac) autonomic network in Parkinson's disease (PD) patients and normal controls. 26 PD patients with autonomic dysfunction and 23 age- and sex-matched controls were evaluated by simultaneous ...
Schebesch Karl-Michael - - 2013
The pathophysiology of arterial vasospasm following subarachnoid hemorrhage (SAH) is poorly understood and the contribution of endogenous neuropeptides has not been sufficiently elucidated. Recently, we detected an excessive release of vasoconstrictive neuropeptide Y (NPY) in SAH patients and identified a significant correlation of NPY cerebrospinal fluid (CSF) levels with vasospasm-related ...
Hirano Kazuoki - - 2013
Eosinophilic meningitis is defined as the presence of 10 eosinophils/mm(3) in the cerebrospinal fluid (CSF) or eosinophils accounting for more than 10% of CSF leukocytes. A 76-year-old man who developed cognitive dysfunction and consciousness disturbance had eosinophilic meningitis (his CSF contained 19.0% eosinophils). Because the etiology was unknown, we performed ...
Nyström Niklas - - 2013
Advanced ileocecal Crohn's disease (ICD) is characterized by strictures, inflammation in the enteric nervous system (myenteric plexitis), and a high frequency of NOD2 mutations. Recent findings implicate a role of NOD2 and another CD susceptibility gene, ATG16L1, in the host response against single-stranded RNA (ssRNA) viruses. However, the role of ...
Jack Gyda Hlin Skuladottir - - 2013
Adrenoleukodystrophy (ALD) is a rare X-linked inherited leukodystrophy with a reduced capacity for degradation of very long chain fatty acids (VLCFAs). The intracellular accumulation of VLCFA leads to demyelination in the central nervous system (CNS) and cell destruction in the adrenal glands. ALD primarily affects males; however, females may develop ...
Garland Emily M - - 2013
A 1925 report by Bradbury and Eggleston first described patients with extreme orthostatic hypotension and a low, steady heart rate. Evidence accumulated over the next two decades that patients with orthostatic hypotension include those with pure autonomic failure (PAF), characterized by isolated peripheral autonomic dysfunction and decreased norepinephrine synthesis; multiple ...
Asahina Masato - - 2013
It is well known that autonomic failure is severer in patients with dementia with Lewy bodies (DLB) compared with patients with Parkinson's disease (PD). According to the Braak's hypothesis, Lewy bodies first appear in the olfactory bulb or peripheral autonomic nervous system. Lewy bodies in the peripheral autonomic nervous system ...
Kerasnoudis Antonios - - 2012
BACKGROUND AND PURPOSE: Multifocal motor neuropathy (MMN) is an acquired, immune mediated, and commonly associated with antiganglioside antibodies against GM1 lower motor neuropathy, with an incidence of 1 per 100,000. The usual age of onset is between 20 and 50 years and men appear to be more often affected than ...
Park Man-Choon - - 2012
Spinal cord injury (SCI) without radiographic abnormality (SCIWORA) is estimated to account for 1-9% of the occurrence of SCI. Of these, cervical SCIWORA in children is common, but thoracic SCIWORA delayed onset in adult is much less common. We experienced a case of 38-years old male patient with lower extremity ...
Zorba Orhan Unal - - 2012
OBJECTIVE: To identify autonomic nervous dysfunction in patients with lifelong premature ejaculation. METHODS: The study participants were 25 men with lifelong premature ejaculation and 25 healthy controls. The parameters of 24-hour heart rate variability that are influenced by the autonomic nervous system were compared between the men with lifelong premature ...
Shihman Boris - - 2012
Familial Dysautonomia (FD) is an autosomal recessive genetic disease where autonomic and sensory functions are defective affecting many body systems including the vascular. Plasma level of the neurotransmitter Calcitonin Gene Related Peptide (CGRP) is decreased in FD patients. This compound has been implicated to take part in the pathogenesis of ...
Shin Jee Hyun - - 2012
Cholinergic urticaria with acquired generalized hypohidrosis, and its pathophysiology is not well known. Autoimmunity to sweat glands or to acetylcholine receptors on sweat glands has been mentioned as one of the possible etiologies. Systemic steroid therapy, antihistamines, anticholinergics, and avoidance of the stimulatory situations are recommended for treatment. We experienced ...
Jang Eun Hye EH Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2012
Multiple system atrophy (MSA) is a sporadic, adult-onset disease characterized by progressive degeneration of nervous systems including cerebellar, pyramidal, extrapyramidal, and autonomic system. Although a few recent studies reported that cognitive impairments could occur in patients with MSA, prominent dementia with progressive decline is not a typical clinical manifestation of ...
Xu Xiaorong - - 2012
BACKGROUND: Visceral hypersensitivity is an important etiology of non-erosive reflux disease (NERD). Calcitonin gene-related peptide (CGRP) and substance P (SP) are involved in the sensitization of afferent neuronal pathways. AIM: The objectives of this study were to evaluate visceral hypersensitivity in NERD patients, investigate the association between visceral hypersensitivity and ...
Faustino Massimiliano M - - 2012
OBJECTIVE: The origin and mechanisms of focal and macro-re-entrant atrial tachycardia occurring after ablation of paroxysmal or persistent atrial fibrillation are difficult to determine and are often the cause of distress for both patients and electrophysiologists. The purpose of this study was to describe a novel practical approach which would ...
Paggi S - - 2012
Background and study aims: Narrow-band imaging (NBI) has shown promising results in discriminating adenomatous from non-adenomatous colonic polyps. In patients with small polyps (< 10 mm), the application of NBI within a "resect and discard" strategy, might allow post-polypectomy surveillance intervals to be determined independently from histopathology. The aim of ...
Mizuno Hiroya - - 2012
The aim of this study is to evaluate the benefit of manually controlled steerable sheath, which provides greater flexibility and stability, in mapping and ablation procedure of ventricular tachycardia. We retrospectively reviewed 40 patients who underwent epicardial mapping and conclusive ablation. The first attempt to reach the primary endpoint defined ...
Depew Zachary S - - 2012
While prognostically valuable, physical activity monitoring is not routinely performed for patients with COPD. We aimed to determine the number of daily steps associated with severe physical inactivity (physical activity level <1.40) in this population. We found that a daily step value <4580 is associated with severe physical inactivity. Our ...
Hindricks Gerhard - - 2012
In today's clinical practice the diagnosis of atrial fibrillation (AF) is made by an ECG documentation which fulfills established criteria(1). That documentation is of utmost clinical importance because it is the basis for further therapeutic interventions, such as rhythm control strategies or introduction of oral anticoagulation. ECG documentation of AF, ...
Turner Laura J - - 2012
PURPOSE:: There are a variety of devices currently available to measure physical activity. Activity monitors are technologically advanced and provide complex data, leading to higher costs. Pedometers are simple, inexpensive devices that provide easy-to-view data. The aim of this study was to determine the reliability of pedometer step counting during ...
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