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Oh S J - - 1989
Among 13 patients with the Lambert-Eaton myathenic syndrome (LEMS), three different patterns on the repetitive nerve stimulation test were observed at the time of initial testing. Type 1 pattern, seen in one patient, had low normal CMAP amplitude, decremental response at the low rate of stimulation (LRS), and relatively normal ...
Perry R R - - 1989
Tracheoesophageal fistula (TEF) occurs only rarely in the patient with lymphoma. Two cases are presented to illustrate the challenges in managing TEF in this patient population. Most of the 38 previously reported cases have occurred in patients who have undergone radiation therapy, although several patients have had TEF as an ...
Giagheddu M - - 1989
From 1.1.1958 to 31.12.1986, 110 cases of MG were observed in Sardinia, with a mean annual incidence of 2.5 x 1,000,000 inhabitants and prevalence rates of 7.5, 17.6, 31.4 and 45.0 x 1,000,000 inhabitants respectively (prevalence days: 15.10.1961, 24.10.1971, 25.10.1981 and 31.12.1986). The disease was found to be more frequent ...
Carey R W - - 1989
Thrombotic microangiopathy (TM) occurred 14 to 27 months after last chemotherapy in two patients with diffuse large cell lymphoma and in one patient with Hodgkin's disease. Death from TM occurred in two patients who had no evidence of lymphoma at postmortem examination, and the lone survivor's disease is in complete ...
David M - - 1989
Direct and indirect immunofluorescent studies (DIF, IIF) were performed on 24 pemphigus vulgaris patients who were in a state of clinical remission. The tests were repeated after an interval of 6 months. All the patients were on maintenance therapy with oral prednisone. The DIF in eight patients showed negative results ...
Shimizu K - - 1989
We reviewed the records of 107 patients with non-Hodgkin's lymphoma (NHL) to evaluate the relation between second primary neoplasms and the NHL immunophenotype. The incidence of second primary neoplasms was 3.7%. There were one case of hepatocellular carcinoma and 3 cases of gastric adenocarcinoma including one patient who had a ...
Lahav M - - 1989
We report a case of idiopathic cold agglutinin disease (ICAD) that responded well to corticosteroid therapy, though generally these patients show no response to such therapy. The cold agglutinins in this patient were found to be of low titer (1:32) and wide thermal range (4-37 degrees C). Three patients with ...
Jabre J F - - 1989
The diagnostic usefulness of single-fiber electromyography (SFEMG) in the diagnosis of neuromuscular transmission disorders is well established. Increased jitter is one of the earliest indications of abnormality. In patients with severe weakness, tremor, or altered consciousness, performance of the study is difficult because of the degree of cooperation needed. We ...
Somer H - - 1989
Patient registers on myasthenia gravis (94 patients) and multiple sclerosis (991 patients) from a population of 1.5 million were reviewed to find patients with both diseases. Seven potential candidates were found, but both diagnoses were confirmed in 2 women only. The first patient had also iritis, the second patient had, ...
Sheehan-Dare R A - - 1988
Seventy patients with lymphomas and leukaemias were interviewed. Details of past acne vulgaris were recorded and a clinical examination performed. A history of acne was less common in the patients than in matched controls. In addition, fewer patients had received treatment prescribed by a medical practitioner for their acne than ...
Ellis K - - 1988
From 1973 through 1986, 154 consecutive patients who had a transsternal thymectomy for myasthenia gravis had preoperative radiologic evaluation for a possible thymoma. Examinations included posteroanterior and lateral (n = 154) and shallow oblique (n = 126) chest radiography, linear tomography (n = 80), and chest CT (n = 96). ...
Parris W C - - 1988
Two cases are presented of malignant hyperthermia in black patients. One patient developed signs of malignant hyperthermia during general anesthesia that was successfully treated with dantrolene sodium and cooling. A second patient was retrospectively diagnosed as having an atypical variant of malignant hyperthermia secondary to heat stroke and general anesthesia; ...
Majer M C - - 1988
Fifty-seven patients with palpably enlarged peripheral lymph nodes underwent detailed ultrasonographic (US) examination with a 5.0-MHz and a 7.5-MHz probe. In 32 of 36 patients with malignant lymphoma (12 with Hodgkin disease, 24 with non-Hodgkin lymphoma) US showed a hypoechoic mass with a centrally located tubular structure. Pathologic examination showed ...
Addonizio G - - 1988
This retrospective study examined the common notion that neuroleptic-induced dystonia is less frequent in elderly patients. The hospital records of 45 young patients and 45 elderly patients were reviewed. Thirty-one percent of the young patients developed dystonia, compared to 2% of the elderly patients. This significant difference did not appear ...
Barthelemy H - - 1988
The effects of cyclosporine were studied in nine patients suffering from pemphigus vulgaris. Of four patients treated with cyclosporine alone, only one cleared. Of four corticosteroid-resistant pemphigus vulgaris patients, all improved after cyclosporine addition to corticosteroids. The last patient treated from the beginning with a combined treatment (cyclosporine-corticosteroids) did not ...
Garcia Erro M I - - 1988
Twelve patients between 15 months and 13 years of age with clinical and pharmacological features of myasthenia gravis were studied. Repetitive nerve stimulation did not offer valuable information; the patients demonstrated either inspecific muscular decremental response or had normal behavior. Two clear groups of patients were identified after measurements of ...
Wolf R - - 1988
We report our experience in the treatment of two patients with aquagenic pruritus of the elderly and two patients with aquagenic pruritus. Our findings confirm previous reports by others indicating that aquagenic pruritus is not one homogenous entity but rather is composed of two similar but distinct entities, each of ...
Arsura E L - - 1988
The authors administered repeated courses of intravenous immunoglobulin (IVIg) to nine patients at the onset of an exacerbation of generalized myasthenia gravis (MG). Anticholinesterase medication (nine patients) and corticosteroid dosage (six patients) had been kept constant for a 2-month period. Six patients received two courses, two patients received three courses, ...
Soliven B C - - 1988
Of 221 patients with myasthenia gravis, 18.5% had no detectable antibodies to acetylcholine receptor. Seven of 14 patients (50%) with only ocular symptoms for more than 2 years were seronegative, and 25 of 145 (17%) patients with generalized myasthenia were seronegative. The clinical characteristics of seronegative patients did not differ ...
Nyberg-Hansen R - - 1988
Six patients (4 females, 2 males) with generalized myasthenia gravis (MG) have been treated in an open study with ciclosporin (5-10 mg/kg/day), originally for 28 weeks. The age of the patients ranged from 16-61 years and the duration of symptoms from 5-30 years. Four of the patients had been thymectomized. ...
Weisenthal R - - 1988
Malignant lymphocytic lymphoma rarely involves the eye. In two patients we found ocular signs and symptoms as the initial presentation of systemic disease. In the first patient periorbital swelling and ptosis of one year's duration ultimately proved to be the result of malignant lymphoma. After resolution of swelling and ptosis ...
Ording H - - 1988
Neuromuscular blockade was obtained with vecuronium 108 micrograms kg-1 in 44 patients undergoing diagnostic muscle biopsy as part of an investigation of malignant hyperthermia (MH) susceptibility. At the termination of anaesthesia doxapram 1.43 mg kg-1 was given in an attempt to antagonize postoperative respiratory depression. Rectal, muscle and skin temperatures, ...
St Louis M E - - 1988
Diagnosis of botulism in two teenaged sisters in Montreal led to the identification of 36 previously unrecognized cases of type B botulism in persons who had eaten at a restaurant in Vancouver, British Columbia, during the preceding 6 weeks. A case-control study implicated a new vehicle for botulism, commercial chopped ...
Ganczarczyk M L - - 1988
Nailfold capillary microscopy was performed in 19 patients with polymyositis (PM) and 16 with dermatomyositis (DM). Enlarged capillary loops were seen more frequently in patients with DM (56%) than in those with PM (21%). Avascular lesions occurred in both PM and DM, but were more prevalent and more severe in ...
Valli G - - 1987
The clinical conditions of 110 patients affected by myasthenia gravis (MG) were followed from two to twelve years. Patients with thymectomy showed a statistically higher percentage of clinical remissions than patients without thymectomy. In patients without clinical remission immunosuppressive drugs were prescribed in different schedule; the greater percentage of pharmacological ...
Jootar S - - 1987
Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a disease of unknown etiology and pathogenesis. It has the features of hyperimmunity and immune deficiency, and its behavior resembles malignant lymphoma. We report a review of 16 patients with AILD seen at Ramathibodi Hospital from 1982 to 1986. Thirteen patients had fever and ...
Eedy D J - - 1987
In a retrospective study we measured the incidence of internal malignancy in patients diagnosed as having Bowen's disease, in Northern Ireland, between 1970 and 1983. Data on 157 patients were obtained from hospital notes, death certificates, the Northern Ireland Cancer Registry and the patients' general practitioners. There was a preponderance ...
Papatestas A E - - 1987
Factors influencing onset of remission in myasthenia gravis were evaluated in 2062 patients, of whom 962 had had thymectomy. Multivariate analysis showed that appearance of early remissions among all patients was significantly and independently influenced by thymectomy, by milder disease, and by absence of coexisting thymomas. Patients with mild generalized ...
Paul R - - 1987
When 125 patients with generalized pruritus were followed up for 6 years, 66% reported continuing pruritus. In four patients a malignancy had been identified at the time of the initial examination, and four other patients developed malignancies during the follow-up period. Seven of the patients died of the malignancy during ...
Albera R - - 1987
The modifications of stapedial reflex have been studied in 30 subjects affected by myasthenia gravis. The test was performed in basal conditions (i.e. at least 6 h after the last administration of an anticholinesterase drug), after the injection of Tensilon and again in basal conditions, 1 week after thymectomy. The ...
Scherpbier H J - - 1987
In a selected group of 69 patients with myasthenia gravis treated with prednisone, the factors were studied that might have influenced the reoccurrence or exacerbation of clinical signs after initial improvement in two-thirds of the patients. It was not evident that the speed of dose reduction was responsible for the ...
Bruch K - - 1987
A total of 325 patients all older than 65 years (45 of more than 80 years of age) were treated with ofloxacin during phase II studies. The relative efficacy of ofloxacin in the comparative studies in the elderly patients was comparable to that in the younger patients. However cure rates ...
Ranklev E - - 1986
Patients (155) were investigated for malignant hyperthermia susceptibility (MHS), by in vitro testing of muscle taken from the vastus medialis muscle. Histopathological and histochemical investigation of muscle was also performed. Ultrastructural investigation was performed in 13 MHS patients; 90% of the patients replied to a questionnaire concerning present or previous ...
Goto I - - 1986
Studies showed a significant decrease in the macrophage neutral protease and lymphocyte acid protease activities in patients with multiple sclerosis in remission, a significantly decreased neutral protease activity in macrophages in patients with myasthenia gravis and a significantly decreased acid protease activity in macrophages and lymphocytes in patients with polymyositis. ...
Nagami P - - 1986
Bacteriuria is not thought to cause progressive renal damage in the asymptomatic adult. Therefore, in the elderly patient with relapsing asymptomatic bacteriuria, further antibiotic therapy may be withheld, and the patient instructed to return in the event of symptomatic exacerbations. Postherpetic neuralgia is particularly frequent and severe in the elderly, ...
English D R - - 1986
One hundred and three patients with cutaneous malignant melanoma responded to an invitation to attend a dermatology outpatient clinic. All patients with a family history of melanoma, a history of multiple melanomas, or histological evidence of a dysplastic naevus that was associated with their melanoma were invited. A random sample ...
Phillips M E - - 1986
A retrospective study of 21 patients with the histopathologic diagnosis of minimal deviation melanoma (MDM; n = 18) and borderline melanoma (BM; n = 3) was undertaken to determine the prognosis for these patients compared with that for patients with other types of malignant melanoma. The findings indicate that the ...
Roscoe J T - - 1986
Levels of thymosin alpha I in the sera of 37 patients with Brazilian pemphigus foliaceus (BPF) were measured using a competitive binding radioimmunoassay. The values were compared with 19 patients with other forms of pemphigus, 13 relatives of patients with BPF, 18 patients with other dermatological diseases, and 265 normal ...
Bramwell N H - - 1986
A patient with myasthenia gravis underwent thymectomy following the failure of medical treatment. The thymus was normal except for four nodules, which, on histologic and electron microscopic examination, were found to consist of proliferative clusters of Langerhans' cells characteristic of histiocytosis X. This patient therefore had two disease processes in ...
Mikkelsen B - - 1986
Two cases of late-onset myasthenia gravis were successfully treated by thymectomy using a sternal splitting technique, in spite of the fact that no thymomas could be detected preoperatively. One patient was seriously ill, the other patient responded to medical treatment. Thymolipoma and malignant thymoma, respectively, were removed from the patients. ...
Argov Z - - 1986
Ampicillin trihydrate aggravated the symptoms of two myasthenic patients. One patient had severe temporary weakness after an ampicillin sodium challenge. Ampicillin increased the preexisting electrical decrement in three rabbits with experimental autoimmune myasthenia gravis while the drug had no deleterious effects in less affected or normal animals. Myasthenic patients receiving ...
Beemer G H - - 1986
One hundred patients who received a competitive neuromuscular blocking agent during anaesthesia were randomly selected for evaluation of neuromuscular function immediately on their arrival in the recovery room. The anaesthetist was not aware that the patient would be evaluated in the recovery room. Neuromuscular function was assessed by a train-of-four ...
Bargman H B - - 1986
A middle-aged man developed multiple dermatofibromas on the legs and arms. The lesions were about sixty in number and were unusual in their rapid onset, their larger-than-average size, and their appearance in large numbers on the arms and trunk. They started approximately 4 months after the patient had begun a ...
Offit K - - 1986
A patient with angioimmunoblastic lymphadenopathy with dysproteinemia had a monoclonal IgG hypergammaglobulinemia. In contrast to previous reports, the development of a monoclonal paraprotein in the setting of angioimmunoblastic lymphadenopathy with dysproteinemia did not herald a transformation to malignancy. The patient improved clinically and the monoclonal gammopathy disappeared when the patient ...
Engervall P - - 1986
Fifteen patients with lymphoid malignancies and tumour-related fever (greater than 38.0 degrees C) were given 50 mg indomethacin (IM) orally. This resulted in a reduction of body temperature in all cases (mean +/- SD 3.4 +/- 2.0 degrees C). In one patient with untreated Hodgkin's disease, temperature fell from 40.6 ...
Vance R B - - 1986
The treatment of malignant gliomas with cisplatin has been shown to be of benefit. In order to reduce the side effects of the drug, we employed the use of sodium thiosulfate in ten patients one hour after cisplatin infusion and continued for 6 h. Side effects from this population of ...
Mørk N J - - 1986
In an open uncontrolled study eight patients with vulval lichen sclerosus et atrophicus were given etretinate (Tigason) 1 mg/kg/day. The dose was then gradually reduced according to effect and side effects. Six patients showed improvement in symptoms and in clinical morphology based on the physician's evaluation and photographic documentation. In ...
Andersen M - - 1986
Transcervical thymectomy was performed during a 13-year period in 21 patients with nonthymomatous myasthenia gravis. Follow-up showed that only eight patients benefited from the operation. These eight were among the younger patients in the series. This observation is discussed, and also the theoretic background for early thymectomy. The transsternal approach ...
Pollack M S - - 1985
The frequency of HLA-DR5 was significantly increased in a large group of malignant melanoma patients (33.7% vs 20.5% for controls). The subgroup of patients with poor prognosis showed both a DR5 increase and a relative decrease in DR1. Although none of these differences was significant after correction for the number ...
Vincent A - - 1985
Twenty-five myasthenia gravis (MG) patients whose anti-acetylcholine receptor (anti-AChR) titres against denervated human leg AChR fell in the range of less than 0.1-2.0 nM were tested against AChR preparations from normal human leg muscle, and from human extra-ocular muscle, and the results compared with those of sera with titres greater ...
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