Search Results
Results 451 - 500 of 1238
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Stone William M - - 2008
The risk of cerebrovascular events in patients with mild to moderate peripheral vascular disease is significant. Cilostazol is a phosphodiesterase type 3 (PDE3) inhibitor that is effective in the treatment of symptoms of peripheral arterial occlusive disease. The method of action includes antithrombotic, vasodilatory, and antiproliferative effects. The Cilostazol: A ...
Song Zhi - - 2008
A number of clinical trials have examined whether antibiotics decrease the incidence of adverse events in patients with cardiovascular diseases. However, results have occasionally been conflicting, and a meta-analysis may provide additional clarification. To address whether antibiotic use can reduce the risk of future cardiac events among patients with established ...
Rothberg Michael B - - 2008
Chronic kidney disease (CKD) is a growing problem among the elderly. Early detection is considered essential to ensure proper treatment and to avoid drug toxicity, but detection is challenging because elderly patients with CKD often have normal serum creatinine levels. We hypothesized that most cases of CKD in the elderly ...
Kamber Niklaus - - 2008
OBJECTIVE: To determine the incidence of lactic acidosis in community-based patients with type 2 diabetes, with special reference to metformin therapy. DESIGN: Substudy within a longitudinal observational study, the Fremantle Diabetes Study (FDS). PARTICIPANTS AND SETTING: 1279 patients from a postcode-defined population of 120 097 people in Western Australia. MAIN ...
Kellett John - - 2008
BACKGROUND: Predictive scores such as APACHE II have been used to assess patients in intensive care units, but few scores have been used to assess acutely ill general medical patients. DESIGN: Examination of the ability of clinical variables documented at the time of admission to predict early mortality between 15 ...
Pfeffer Marc A - - 2008
Epidemiologic observations showing associations between higher levels of some biologic markers such as blood pressure and serum cholesterol with heightened risk of death and non-fatal cardiovascular events have provided important data to develop hypotheses regarding pharmacologic therapies to modify these markers to improve prognosis. Randomized controlled trials have shown that ...
Cauthen Clay A - - 2008
Patients with chronic kidney disease and heart failure (HF) have been shown to be at higher risk for major adverse cardiovascular events and death. Recent studies have demonstrated that blood urea nitrogen (BUN) might serve as a powerful predictor of mortality in acutely decompensated HF. The goal of this study ...
Overgaard Christopher B - - 2008
BACKGROUND: Thrombocytopenia (TP) is a common baseline abnormality in patients undergoing percutaneous coronary intervention (PCI). Whether TP has any influence on the outcome of PCI patients is unknown. Our aim was to determine if TP at baseline impacts on inhospital mortality in patients undergoing PCI at our institution. METHODS: From ...
López-Jiménez Luciano - - 2008
There is little information on the effectiveness of secondary prevention interventions in very elderly patients. In this article, the incidence of major cardiovascular events during a 12-month follow-up period in a series of consecutive patients with coronary, cerebrovascular, or peripheral artery disease is analyzed. As of October 2006, 1264 patients ...
De Waele Jan J - - 2008
BACKGROUND: Blood stream infections (BSI) of abdominal origin are associated with a high mortality rate. We hypothesized that both patient and microbiological factors determine death in critically ill patients who develop such infections. METHODS: Ninety-six consecutive patients who developed BSI of abdominal origin in an 11-year period (1992-2002) in the ...
Barros Mário Henrique M - - 2008
BACKGROUND: A risk group (RG) system to predict bone marrow involvement (BMI) based on clinical and laboratory parameters was previously shown to have prognostic value in adult patients with Hodgkin lymphoma (HL). Our aim was to test the applicability of BMI RG in an independent group of childhood and adolescent ...
Wish J B - - 2008
AIMS: Anemia and cardiovascular (CV) events are major complications of chronic kidney disease (CKD) during dialysis. We conducted a retrospective observational study in CKD patients with anemia to evaluate the association between predialysis use of erythropoiesis-stimulating agents (ESAs) and postdialysis CV outcomes. METHODS: The study analyzed claims data on incident ...
Unalp H R - - 2008
CONTEXT: Fournier's gangrene (FG) is a rapidly progressing acute gangrenous infection of the anorectal and urogenital area. AIMS: The objectives of this study were to investigate patients with FG and to determine risk factors that affect mortality. SETTINGS AND DESIGN: Retrospective clinical study. MATERIALS AND METHODS: Clinical presentations and outcomes ...
Park Jai-Wun - - 2008
OBJECTIVE: Magnetocardiography (MCG) as a noninvasive, noncontact and risk-free diagnostic method predicts ischemic coronary artery disease (CAD) in patients with acute chest pain at admission with high accuracy. However, it remains unclear whether MCG findings can add prognostic information. METHOD: A cohort of 402 consecutive patients presenting at the intensive ...
Kosuge Masami - - 2008
BACKGROUND: The impact of body mass index (BMI) on outcomes after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) remains unclear. METHODS AND RESULTS: A total of 3,076 patients undergoing PCI for AMI within 48 h after symptom onset were studied. Patients were divided into 4 groups according ...
Iqbal Mobeen - - 2008
Hypocalcemia has been a common abnormality in the West, seen in patients admitted to the intensive care unit (ICU). It has also been linked with disease severity. We undertook this study to determine the frequency of hypocalcemia in patients admitted to the intensive care unit. In a retrospective chart review ...
Tsai Shih-Hung - - 2008
BACKGROUND: Diabetes mellitus (DM) is associated with adverse events or complications in various gastrointestinal diseases. In this study, we examined whether diabetic patients had higher risk for the development of complicated acute appendicitis than nondiabetic patients. The relevant risk factors also were determined. METHODS: A retrospective study enrolling diabetic and ...
Rueda Sergio F - - 2009
OBJECTIVE: The aim of this study was to describe the prevalence of cardiovascular disease risk factors (CVDRFs) and the degree of control in a Spanish population of patients with type 1 diabetes (DM1) and end-stage renal disease (ESRD) as well as the changes observed in this setting over 8 years. ...
Wang Tracy Y - - 2008
AIMS: To examine treatment patterns and outcomes of patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS) receiving long-term warfarin anticoagulation. METHODS AND RESULTS: We examined acute medication and invasive cardiac procedure use and in-hospital outcomes among 101,078 patients with NSTE ACS included in the CRUSADE registry. On admission, 7201 ...
Dunkelgrun M - - 2009
BACKGROUND: Hyperhomocysteinaemia is independently associated with atherosclerotic disease. Methionine loading could improve the predictive value of hyperhomocysteinaemia by detecting mild disturbances in enzyme activity. The aims of this study were to determine the beneficial effect of methionine loading on the predictive value of homocysteine testing for long-term mortality and major ...
Sari Ali B A - - 2008
OBJECTIVES: to estimate the extent, preventability and consequences of adverse clinical events in elderly and non-elderly patients. DESIGN: a two-stage structured, retrospective, patient case-note review. SETTING: a large NHS hospital in England. Population: a random sample of 1,006 non-psychiatric patients. Main Outcome Measures: proportion of patients with adverse events, the ...
Barsheshet Alon - - 2008
A widened QRS interval is associated with increased mortality in patients with heart failure (HF). However, the prognostic significance of the type of bundle branch block (BBB) pattern in these patients is unclear. The data of 4,102 patients with HF hospitalized during a prospective national survey were analyzed to investigate ...
Wright D M - - 2008
In this prospective study, 230 patients who were operated on for a fractured neck of femur were evaluated using the physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM). We observed 25 deaths (10.9%) and 95 patients had a post-operative complication (41.3%). The orthopaedic POSSUM equations ...
Yeo Khung Keong - - 2008
Guidelines published by the National Kidney Foundation in 2002 categorize renal failure into 5 stages of increasing severity. The relation of this classification to risk stratification for operative mortality in patients with nonemergent coronary artery bypass grafting (CABG) has not been clarified. We examined the effect of chronic kidney disease ...
Cardarelli Francesca - - 2008
BACKGROUND: Chronic kidney disease (CKD) is a predictor of morbidity and mortality in patients undergoing percutaneous coronary interventions (PCIs), and African American (AA) patients have been reported to have worse outcomes after PCI. METHODS: We assessed whether CKD affects the rate of death and major adverse cardiovascular events (MACE = ...
Kapoor Rachna - - 2008
PURPOSE: Two instruments for assessing patients' risk of postoperative nausea and vomiting (PONV) were compared. METHODS: The existing protocol (protocol 1) assessed PONV risk using 16 weighted risk factors and was used for both adults and pediatric patients. The new protocol (protocol 2) included a form for adults and a ...
Chew M H - - 2008
INTRODUCTION: Controversy persists regarding ideal management strategies in well-differentiated thyroid cancers (WDTC). This retrospective study reviews the utilization of a modified AMES risk stratification in the management of our institution's patients. METHODS: A total of 352 patients (median follow-up of 5.5 years) were reviewed and were risk stratified. Surgical resection ...
Melloni Chiara - - 2008
BACKGROUND: The prognostic value of cardiac troponins (cTn) in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) and chronic kidney disease (CKD) is debated. HYPOTHESIS: We tested the performance of cTnI and cTnT for risk stratification in patients with CKD and evaluated the prognostic significance of cTnI and cTnT ...
Ross Chaim - - 2008
Gastrointestinal endoscopies are common procedures for diagnosis and treatment. Patients with various cardiovascular conditions can undergo these procedures, including those patients with acute myocardial infarction, but appropriate precautions need to be maintained, especially with procedure-induced autonomic nervous system pertubations that can affect heart rate and blood pressure. In this article, ...
Colaci M - - 2008
OBJECTIVE: Systemic sclerosis (SSc) is characterized by Raynaud's phenomenon and frequent cutaneous ulcers. In patients resistant to oral treatments, i.v. prostanoids are usefully employed. Some anecdotal reports underlined the potential risk to develop cardiovascular ischemic complications in prostanoid-treated SSc patients. METHODS: Fifty SSc patients (group 1: 44 female and 6 ...
Schmitt Brian P - - 2008
BACKGROUND: For patients at high risk of function-limiting or life-limiting disease, the time elapsed between first clinical presentation, diagnosis, and treatment can influence the likelihood of treatment success. METHODS: A systematic change in the management of high-risk patients was undertaken. This approach includes identifying primary provider responsibility, establishing communication expectations ...
Moodley I I Health Outcomes Research Unit, Department of Public Health and Family Medicine, Nelson R Mandela School of Medicine, - - 2008
There is no doubt that NSAIDs and COXIBS are the mainstay for managing pain and inflammation in arthritis. Overall, at therapeutically equivalent doses, both NSAIDs and COXIBs provide equivalent analgesic and anti-inflammatory efficacy. However, the gastrointestinal risk associated with NSAIDs is considerable. More recently, the cardiovascular risk associated with NSAIDs ...
Deedwania Prakash - - 2008
Hyperglycemia is common and associated with markedly increased mortality rates in patients hospitalized with acute coronary syndromes (ACS). Despite the fact that several studies have documented this association, hyperglycemia remains underappreciated as a risk factor, and it is frequently untreated in ACS patients. This is in large part due to ...
Núñez Julio - - 2008
Neutrophil to lymphocyte ratio (N/L) has been associated with poor outcomes in patients who underwent cardiac angiography. Nevertheless, its role for risk stratification in acute coronary syndromes, specifically in patients with ST-segment elevation myocardial infarction (STEMI), has not been elucidated. We sought to determine the association of N/L maximum value ...
Arnoux J B - - 2008
The congenital disorder of glycosylation type Ia (CDG-Ia) presents a broad clinical spectrum. Some patients suffer from acute vascular events (thrombosis and bleeding) and stroke-like events. No correlations have been made between the marked hemostasis abnormalities of CDG-Ia and the occurrence of acute vascular events. We report on 6 patients ...
Doenst Torsten - - 2008
OBJECTIVE: Due to modern techniques of cardio protection, less attention has been paid to aortic cross-clamp (XCL) times. However, patients with impaired cardiac contractile function are still at increased perioperative risk, which may be partially due to an increased susceptibility to myocardial ischemia. We tested whether XCL times are associated ...
Daccarett Marcos - - 2008
Bradyarrhythmias (BA) have been reported in patients with sleep apnea (SA), but the incidence of SA in patients with BA remains unclear. A case-control study was conducted to assess the prevalence of high-risk features of SA in patients with documented BA on 24-hour Holter monitoring compared with patients without BA. ...
Lee Cindy H - - 2008
BACKGROUND: Despite the recommendation for an early invasive strategy in the treatment of patients who present with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS), referral for cardiac catheterization is suboptimal; the reasons why some patients are not referred remain unclear. METHODS: Patients were recruited into the prospective, observational Canadian ACS ...
Schnabel Renate - - 2008
AIMS: In primary prevention, the adipocytokine adiponectin seems to be protective against diabetes mellitus and cardiovascular disease. Data in patients with manifest coronary artery disease (CAD) are scant stimulating the investigation of the association of adiponectin concentrations and cardiovascular outcome in a prospective CAD cohort. METHODS AND RESULTS: In 1890 ...
Mehta Rajendra H - - 2008
BACKGROUND: There exist few studies that characterize contemporary clinical features and outcomes or risk factors for operative mortality in cardiogenic shock (CS) patients undergoing coronary artery bypass grafting (CABG). METHODS AND RESULTS: We evaluated data of 708,593 patients with and without CS undergoing CABG enrolled in the Society of Thoracic ...
Ligi Isabelle - - 2008
BACKGROUND: Iatrogenic events are increasingly recognised as an important problem in all people admitted to hospital. However, few epidemiological data are available for iatrogenic events in neonatal high-risk units. We aimed to assess the incidence, nature, preventability, and severity of iatrogenic events in a neonatal centre and to establish the ...
Iseki Kunitoshi - - 2008
Sleep apnea syndrome, a sleep-related breathing disorder (SRBD) of which obstructive sleep apnea syndrome (OSAS) is representative, is often associated with obesity, and therefore patients with SRBD might have a high prevalence of chronic kidney disease (CKD). However, the relationship between obesity and the prevalence of CKD has not yet ...
Rydahl Casper - - 2008
OBJECTIVE: Nephrogenic systemic fibrosis (NSF) is a serious disease affecting renal failure patients. It may be caused by some gadolinium (Gd)-containing contrast agents, including gadodiamide. The study aimed at estimating the prevalence of NSF after gadodiamide exposure for patients with chronic kidney disease (CKD). MATERIALS AND METHODS: Retrospective cohort study ...
McLaughlin Daniel F - - 2008
BACKGROUND: Massive transfusion (MT) is associated with increased morbidity and mortality in severely injured patients. Early and aggressive use of blood products in these patients may correct coagulopathy, control bleeding, and improve outcomes. However, rapid identification of patients at risk for MT has been difficult. We postulated that evaluation of ...
Al-Mallah Mouaz - - 2008
BACKGROUND: Elevated troponin I has been associated with increased mortality in critically ill patients without acute coronary syndrome (ACS). However, the prognostic significance of troponin elevation in patients with diabetic ketoacidosis (DKA) without evident ACS has not been studied. METHODS: Retrospective study of all patients admitted to a U.S. tertiary ...
Sabouret P - - 2008
Atherothrombosis is a systemic, diffuse disease associated with a high risk of cardiovascular morbidity and mortality. It is the main cause of death in Western populations, a major public health concern and its prevalence will further increase in the future. To evaluate the rate of major vascular events at 1 ...
Uehara Ritei - - 2008
BACKGROUND: Some Kawasaki disease (KD) patients do not respond to initial treatment with intravenous immunoglobulin (IVIG). The purpose of this study was to determine potential risk factors associated with IVIG nonresponse among KD patients in Japan. METHODS: Data were obtained from questionnaires used for the 18th nationwide KD survey of ...
Ptaszynski Pawel - - 2008
AIMS: We hypothesize that the neural component (NC) of the baroreflex sensitivity (BRS) is a better risk stratifier for ventricular tachycardia/fibrillation (VT/VF) than conventional BRS itself, because it is both independent of vessel wall stiffness and can be measured non-invasively. METHODS AND RESULTS: NC was determined by correlating spontaneous carotid ...
Giamouzis Grigorios - - 2008
A high cardiothoracic ratio (CTR) is a marker of an enlarged heart and is associated with poor outcomes in patients with heart failure (HF). To what extent this association is independent of other confounders is not well known. However, to study this, propensity score matching was used to design a ...
Goldenberg Ilan - - 2008
OBJECTIVES: The study was designed to develop a simple risk stratification score for primary therapy with an implantable cardioverter-defibrillator (ICD). BACKGROUND: Current guidelines recommend primary ICD therapy in patients with a low ejection fraction (EF). However, the benefit of the ICD in the low EF population may not be uniform. ...
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