Aims. To study ocular changes in patients with endocrine ophthalmopathy and to evaluate the possible harmful effect of pollution. Materials and methods. 245 patients with endocrine ophthalmopathy on regular follow-up in 2004–2005 in the Ophthalmology Outpatient Department of the Kaunas Medical University Clinic were recruited for the study. A comprehensive ...

Background: Opiate addicts are generally prone to comorbidities, including neurological disease, because of the toxic effect of the drug, the combined use of opiates, and other neurotoxic substances, infections, bacteriemia from intravenous drug use, atherosclerosis from smoking or hyperlipidemia, trauma, reduced primitive reflexes during intoxication, compression neuropathies, rhabdomyolysis, or rhythm ...

To determine the prevalence of normal tension glaucoma (NTG) in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) and further investigate whether the severity of OSAHS would increase the risk of glaucoma. Two hundred fifty-six participants were consecutively admitted for polysomnographic exam to diagnose OSAHS. All participants, then underwent a complete ...

To compare intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT) and assess their relationship to central corneal thickness (CCT) in patients with primary open angle glaucoma (OAG). GAT, DCT, and CCT were assessed in 116 patients with OAG [mean age 65.9 (10.5); 59% female] ...

To report 2 cases of corneal edema, haze, and thinning in patients after undergoing selective laser trabeculopasty. Selective laser trabeculoplasty was performed for the treatment of primary open-angle glaucoma on 2 patients who subsequently developed corneal stromal haze within 24 to 48 hours of the procedure. The patients were treated ...

Artificial sphincters have been developed for patients with fecal incontinence, but finding a way to make such sphincters more "intelligent" remains a problem. We assessed the function of a novel intelligent artificial anal sphincter (IAAS) in vitro and in vivo in rabbits. After the prosthesis was activated, rabbits were continent ...

Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to ...

To study and compare the clinical and serological features of patients with elderly versus adult and younger onset of primary Sjögren's syndrome (pSS). We analyzed retrospectively 336 consecutive pSS patients followed at our unit. They were subdivided into three groups according to the age at disease onset: elderly (>65years), adult ...

Purpose:  To describe visual function and ocular manifestations in patients with onset of cholestasis during the neonatal period. Methods:  Patients with neonatal cholestasis, either transitory or chronic, who came for assessment to our tertiary referral centre were included in a cross-sectional study and underwent ophthalmological examinations including fundus photography. A ...

(a) To investigate whether the ICare rebound tonometer can provide accurate measurements of intraocular pressure (IOP) in the hands of an inexperienced user compared with ICare measurements and Goldmann tonometry by a trained technician and (b) to assess the intrauser reproducibility of IOP measurements and the learning curve among patients ...

To assess the correlation between central corneal thickness (CCT) and anterior scleral thickness (AST) in Korean patients with normal tension glaucoma (NTG) and primary open angle glaucoma (POAG). Consecutive patients with POAG, NTG, and normal individuals were recruited. Anterior segment optical coherence tomography (AS-OCT, Visante) was used to measure CCT ...

Purpose. To investigate whether Helicobacter pylori infection is associated with normal tension glaucoma (NTG). Methods. One hundred consecutive NTG patients (group 1) from an outpatient glaucoma clinic were enrolled. Medical records of the 88 control participants (control 1) of the outpatient clinic, and 104 NTG patients (group 2) and 1116 ...

To evaluate by Doppler sonography carotid and ocular hemodynamics in Behçet disease with and without ocular involvement. Seventy-six patients with Behçet disease (BD) were separated into three groups: with active uveitis, with inactive uveitis, and without uveitis, and compared with 23 controls. We used duplex Doppler sonography to measure peak ...

To investigate if patients with exfoliation glaucoma (XFG) with cardiovascular disease (CVD) require different target intraocular pressure (IOP) compared to patients with XFG with no CVD for long-term stability. A retrospective, multicenter, observational cohort analysis included consecutive patients with XFG from 9 European academic centers, with a minimum of 5 ...

To identify some of the common denominators in the diverse presentation of retained orbital wooden foreign bodies. A review of 9 cases of previously unrecognized retained orbital wooden foreign bodies. Intervention included surgical removal of the foreign bodies in 8 cases and fistula repair in 1 case after spontaneous foreign ...

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare disorder. This study investigated the types of ocular signs and symptoms in patients with POEMS and any systemic factors that may be associated with development of such ocular findings. Case series from tertiary referral center. A total ...

The aim of this study was to evaluate the concordance of intraocular pressure (IOP) measurements in the supine glaucoma patient using a Perkins applanation tonometer (PAT) compared to the iCare® rebound tonometer (RT), a hand-held device requiring no local anaesthesia. 73 left eyes of 73 glaucoma patients were included in ...

Purpose:  To investigate the measures of validity for selective or population screening of the time-domain Stratus and the spectral-domain Cirrus Optical Coherence Tomography (OCT) imaging techniques in a population-based sample and in clinical glaucoma patients at different stages of glaucoma. Patients and methods:  A random sample of 307 subjects living ...

to investigate the observed high prevalence of spontaneous sub-conjunctival haemorrhage (SCH) in patients using long-term topical steroid treatment. a cross sectional survey of the occurrence of SCH was carried out in 248 patients using steroid eye drops and in a comparison group of 113 patients using topical glaucoma medication. twenty-four ...

OBJECTIVE: To assess the relation between blue-on-yellow perimetry (B/YP) indices and optical coherence tomography (OCT) parameters in normal tension glaucoma (NTG) patients and to investigate the diagnostic ability of B/YP and OCT in discriminating NTG from normal eyes. DESIGN: Cross-sectional study. PARTICIPANTS: Eighty normal subjects (80 eyes) and 80 NTG ...

To determine if Chlamydia pneumoniae infection is associated with primary open-angle glaucoma (POAG). Consecutive patients with newly diagnosed primary POAG attending the Glaucoma clinic of Keio University Hospital between June 2007 and January 2008 were considered for inclusion in this prospective case-control study. Forty consecutive POAG patients and 41 normal ...

OBJECTIVE: To compare adverse intraocular pressure (IOP) spikes in patients receiving intravitreal triamcinolone acetonide (IVTA) in 2 cohorts: (i) patients who underwent a topical prednisolone acetate trial (PAT) without incurring a short-term IOP rise, and (ii) control patients who did not undergo a PAT. DESIGN: Retrospective cohort study. PARTICIPANTS: Charts ...

To evaluate ocular surface histopathologic changes and ocular sequelae in the follow-up of patients with toxic epidermal necrolysis (TEN). Prospective, consecutive, comparative, interventional case series. Eleven patients (22 eyes) with TEN that developed after drug treatment and 33 normal subjects as the control group. Toxic epidermal necrolysis diagnosis was based ...

To describe the clinical features and outcomes in patients with herpetic anterior uveitis. We reviewed the records of 111 patients with a clinical diagnosis of herpetic anterior uveitis seen at the Department of Ophthalmology, Istanbul Faculty of Medicine, from January 1996 to December 2006. Demographic and clinical features, recurrence rate, ...

Aim To compare the diagnostic ability to detect glaucomatous changes between peripapillary retinal nerve fibre layer (RNFL) thickness and the macular ganglion cell complex (GCC) in highly myopic patients using Fourier domain optical coherence tomography. Methods Participants, consecutively enrolled from January 2009 to June 2009, were imaged with RTVue-100 (NHM4 ...

The aim of this study was to evaluate ocular changes in patients with xeroderma pigmentosum (XP) and Cockayne syndrome (CS). Both diseases belong to the progeroid syndromes caused by single gene mutations with premature aging. Both syndromes are very rare autosomal recessive diseases caused by a gene defect leading to ...

To determine rates of visual field change associated with risk factors for progression in the Canadian Glaucoma Study (abnormal anticardiolipin antibody level, age, female sex, and mean follow-up intraocular pressure [IOP]), and to evaluate the effect of IOP reduction on subsequent rates of visual field change in progressing patients. Two ...

to describe the demographic characteristics and ocular manifestations of patients with late-onset Behçet disease (BD). Patients and Methods: The patients for this retrospective study were selected using the data obtained from the medical records of 16 patients with late-onset BD between January 2000 and May 2008. twelve (75%) of the ...

OBJECTIVE: To assess health-related quality of life with Italian SF-36 in patients with uveitis on chronic systemic immunosuppressants. METHODS: Consecutive patients with chronic noninfectious uveitis on systemic immunosuppressive treatment seen at the Ocular Immunology Service, San Raffaele Scientific Institute, Milan, were enrolled. Health status was evaluated with the Italian version ...

PURPOSE: To determine the effectiveness of laser confocal microscopy in identifying Acanthamoeba cysts and trophozoites in the cornea of patients with Acanthamoeba keratitis (AK) and to evaluate its effectiveness in following AK after treatment. METHODS: The corneas of 9 patients clinically diagnosed with AK were monitored periodically with the Heidelberg ...

PURPOSE: To evaluate and compare HLA-DR expression of conjunctival epithelial cells in different grade of conjunctivochalasis (CCh). Patients and METHODS: Thirty patients and seven healthy subjects underwent clinical examination, grading of CCh by lid-parallel conjunctival fold (LIPCOF) test, and impression cytology of the bulbar conjunctiva. HLA-DR expression was analyzed by ...

Aim To measure the bacterial genome in ocular fluids and to analyse the clinical relevance of infectious endophthalmitis. Methods Nineteen ocular fluid samples (eight aqueous humour and 11 vitreous fluid samples) were collected from 19 patients with suspected bacterial endophthalmitis. Fifty ocular samples from uveitis patients were also collected along ...

GH exerts its effects on many organs and the eye also seems to be a target site, although few authors have investigated the corneal thickness in patients with acromegaly. To perform a detailed ophthalmological evaluation in acromegalic patients, in relation to disease activity. Twenty-eight acromegalic patients (11 males, 17 females) ...

To report the results and effectiveness of anterior stromal puncture for contact lens-intolerant keratoconus patients with subepithelial fibrotic nodules. Nine eyes of nine keratoconus patients who were rigid gas-permeable contact lenses (RGP)-intolerant due to subepithelial nodular scars were included in this study. The nine patients were enrolled in the study ...

PURPOSE: To study the characteristics of patients with advanced open-angle glaucoma. METHODS: A hospital-based retrospective study was performed. Advanced glaucoma was defined as visual acuity of 0.3 or less, or mean deviation of -24 dB or less. First, we screened patients with advanced glaucoma and classified their glaucoma types. For ...

OBJECTIVE: To compare distinctive clinical features of presumed tuberculous serpiginouslike choroiditis (Tb-SLC) with classic serpiginous choroiditis (SC) in patients living in a region that is nonendemic for tuberculosis. METHODS: Retrospective comparative analysis of clinical features of 5 patients with recurrent Tb-SLC and 5 with SC. RESULTS: All patients with recurrent ...

To determine factors associated with the test-retest variability of optic nerve head (ONH) topography measurements with confocal scanning laser ophthalmoscopy (CSLO) in newly diagnosed glaucomatous patients. Consecutive patients with newly diagnosed primary open-angle glaucoma were prospectively enrolled. Patients presenting with any ocular disease other than glaucoma were excluded. All patients ...

To compare the incidence of ocular complications (OC) and corneal abrasion (CA) after hand-assisted laparoscopic donor nephrectomy (HALDN) and open donor nephrectomy (ODN). A retrospective review was conducted of 241 consecutive patients (141 HALDN and 100 ODN) over a 9-year period. OC were strictly defined as ocular complaints requiring any ...

OBJECTIVE: To determine the prevalence of selected comorbidities in patients with open-angle glaucoma (OAG) and whether these comorbidities are more prevalent among individuals with OAG than those without OAG. DESIGN: A retrospective, nationwide, case-control study using an administrative database. PARTICIPANTS: The study group comprised 76,673 OAG patients. The comparison group ...

PURPOSE: To assess the ability of Heidelberg Retina Tomograph (HRT) Moorfields Regression Analysis (MRA) and Glaucoma Probability Score (GPS) classifications at baseline to predict glaucomatous progression in ocular hypertensive eyes. METHODS: One hundred ninety-eight ocular hypertensive subjects underwent regular HRT and visual field (VF) testing from 1993 to 2001. HRT ...

The etiology of cataracts in the Asian subcontinent is not well understood. The aim of this study was to understand the differences in nutritional and lifestyle-related etiology of cataract in a high-income group (HIG) and a low-income group (LIG). A cross-sectional survey was conducted on 140 cataract patients, aged 50-70 ...

Intraocular lymphoma (IOL) is rare lymphoma that frequently infiltrates the central nervous system (CNS). An optimal treatment has not been established, and its prognosis is quite poor. We treated three IOL patients with CNS involvement by concurrent administration of intravenous and intravitreal methotrexate (MTX) injection. The intraocular lesion responded in ...

PURPOSE: The purpose of this study was to investigate the tolerability and intraocular pressure (IOP) reducing effect of the first preservative-free prostaglandin tafluprost (Taflotan) in patients exhibiting ocular surface side-effects during latanoprost (Xalatan) treatment. METHODS: A total of 158 patients were enrolled in this open-label multicentre study. Eligible patients had ...

PURPOSE: To investigate the levels of erythropoietin (EPO) and soluble CD44 (sCD44) in the aqueous and plasma of human eyes with primary open-angle glaucoma (POAG), and to correlate their concentration with severity of glaucoma. METHODS: A total of 30 patients with POAG and 25 patients with senile cataract (control group) ...

PURPOSE: The aim of this study was to assess the olfactory function of primary open-angle glaucoma patients. PATIENTS AND METHODS: We analyzed odour threshold, identification, and discrimination in 30 primary open-angle glaucoma patients and 30 age- and gender-matched healthy control subjects. The "Sniffin' Sticks" test battery was applied sequentially on ...

PURPOSE: To investigate the levels of antioxidant enzymes catalase (CAT), glutathione peroxidase (GPO), superoxide dismutase (SOD), and malondialdehyde (MDA) in human eyes with primary open-angle glaucoma (POAG) and to correlate their concentrations with severity of glaucoma. DESIGN: A prospective cases control study. PATIENTS AND METHODS: Thirty patients with primary open-angle ...

OBJECTIVE: To describe the characteristics of uveitis in a Canadian referral centre and to identify predictors of uveitis recurrence. DESIGN: Retrospective cohort study. PARTICIPANTS: Two hundred eighty-five patients with anterior uveitis, intermediate uveitis, or panuveitis. METHODS: We conducted a retrospective study of all patients presenting with anterior uveitis, intermediate uveitis, ...

BACKGROUND: Due to different influences on anterior chamber angle structures, corticosteroids have a significant impact on secondary elevated intraocular pressure. This study examines the influence of corticosteroid therapy on the incidence of secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis (FHC) and chronic anterior uveitis. MATERIALS AND METHODS: ...

INTRODUCTION: Duane syndrome is a difficult condition to treat. Patients and parents need to be informed that it will not resolve and it is not possible to create normal eye movements surgically. Botulinum toxin may be used to assess the likelihood of reducing the abnormal head posture and reducing the ...

BACKGROUND: To determine the prevalence and clinical features of strabismus in patients with pathologic myopia. METHODS: Medical records of a total of 636 highly myopic patients were retrospectively reviewed. Pathologic myopia was defined as spherical equivalent (SE) of at least -8D, or axial length >26.5 mm in patients older than ...