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Page Stephen J SJ S.J. Page, PhD, MS, MOT, OTR/L, FAHA, School of Health and Rehabilitation Sciences, Ohio State University, 453 W Tenth Ave, Columbus, OH 43210 - - 2014
There remains a need for a quickly administered, stroke-specific, bedside measure of active wrist and finger movement for the expanding stroke population. The wrist stability and hand mobility scales of the upper extremity FM (w/h UE FM) constitute a valid, reliable measure of paretic UE impairment in patients with active ...
Toosy Ahmed T AT From the Departments of Brain Repair and Rehabilitation (A.T.T., N.K., A.J.T., O.C.) and Neuroinflammation (D.A., C.A.M.W.-K.), NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, University College London; Institute of Cognitive Neuroscience (N.K.) and NIHR UCL-UCLH Biomedical Research Centre (BRC) (A.J.T., O.C.), University College London, Queen Square; and Medical Statistics Department (D.A.), London School of Hygiene and Tropical Medicine, UK. - - 2014
To apply a novel postprocessing voxel-based analysis for diffusion tensor imaging of the cervical spinal cord in multiple sclerosis (MS) in a prospective cross-sectional study. Fourteen patients with MS who were within 4 weeks of the onset of cervical myelitis (lesion C1-3) and 11 healthy controls underwent cervical spinal cord ...
Gong Su-Gang SG Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. - - 2014
An impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. The present study investigated which IOS measurement is correlated with airflow obstruction, airway conductance and lung volume in chronic obstructive pulmonary disease (COPD). A total of 180 patients with COPD were selected and 95 agreed to follow‑up 1 year after the initial ...
Engelhardt Michael M Department of Vascular and Endovascular Surgery, Military Hospital Ulm, - - 2014
Aim of the study was to validate a newly developed disease-specific quality of life questionnaire (Wuerzburg Wound Score, WWS) in patients with chronic arterial or venous leg ulcers. In this prospective study 115 patients with vascular disease associated leg ulcer (54 arterial ulcer, 61 venous ulcer) were studied (mean age ...
Torre-Alonso Juan Carlos JC From the Facultad de Medicina; Hospital Monte Naranco, Oviedo; Hospital Parc Tauli, Sabadell; Complejo Hospitalario Toledo, Toledo; Hospital Virgen de la Concha, Zamora; Hospital Can Mises, Ibiza; Hospital Universitario de la Princesa; Hospital Alcorcon, Madrid; University Hospital "Reina Sofía"/IMIBIC, Cordoba; Centro Salud Riosa, Astorias, Spain. Supported in part by a grant from Pfizer for the Investigator Initiated Research project "Development and validation of a new instrument to assess health related quality of life in psoriasis arthritis: the Vitacora-19 questionnaire." J.C. Torre-Alonso, MD, PhD, Facultad de Medicina, Hospital Monte Naranco; J. Gratacós, MD, PhD; M. Moreno, MD, Hospital Parc Tauli; J.S. Rey-Rey, MD, Complejo Hospitalario Toledo; J.P. Valdazo de Diego, MD, Hospital Virgen de la Concha; A. Urriticoechea-Arana, MD, Hospital Can Mises; E. Daudén, MD, PhD, Hospital Universitario de la Princesa; P. Zarco-Montejo, MD, PhD, Hospital Alcorcon; E. Collantes-Estévez, MD, PhD, University Hospital "Reina Sofía"/ IMIBIC, Cordoba; J.A. Fernández-López, MD, PhD, Centro Salud Riosa. Address correspondence to Prof. J.C. Torre-Alonso, Universidad Oviedo, Medicina, Hospital Monte Naranco, Oviedo, Asturias, Spain. E-mail: jctorre@telecable.es. Accepted for publication June 13, - - 2014
To develop/validate an instrument to measure health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA), for use in clinical studies. An item pool of 35 items was generated following standardized procedures. Item reduction was performed using clinimetric and psychometric approaches after administration to 66 patients with PsA. The ...
Yokogawa Naoto N Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center , Fuchu, Tokyo , - - 2014
Objectives. To validate Routine Assessment of Patient Index Data 3 (RAPID3) using a Japanese version of Multidimensional Health Assessment Questionnaire (MDHAQ) with Japanese rheumatoid arthritis (RA) patients and to describe the characteristics of RAPID3 by comparison with Disease Activity Score 28 (DAS28) and Clinical Disease Activity Index (CDAI). Methods. The ...
Trovato Chiara Maria CM *Sapienza University of Rome, Department of Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Viale Regina Elena 324, 00161 Rome †Sapienza University of Rome, Department of Radiology, Viale Regina Elena 324, 00161 - - 2014
Metabolic bone disease remains a significant and common complication of celiac disease (CD). Several studies have demonstrated low bone mineral density (BMD) at the time of CD diagnosis in both children and adults. Low BMD in children and adolescents is defined as an areal BMD (aBMD) less than 2 SD ...
Schoepfer Alain M AM Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois / CHUV, Lausanne, Switzerland. Electronic address: - - 2014
& Aims: Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE), to provide endpoints for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patients' assessments of disease severity. ...
Thamboo Andrew A Division of Pediatric Otolaryngology-Head and Neck Surgery, BC Children's Hospital, Vancouver, British Columbia, - - 2014
Sinonasal disease and, specifically, nasal polyps, occur frequently in children with cystic fibrosis (CF). As survival rates have improved, it has become imperative that otolaryngologists become involved in the care of patients with CF to provide appropriate medical and surgical interventions for sinonasal disease. Despite significant variability in the subjective ...
Torfs Tom T Imec, Kapeldreef 75, Heverlee, Leuven, - - 2014
Detection of intermittent atrial fibrillation (AF) is done using a 24-h Holter. Holter recordings are powerful but lack the comfort and have limited recording times resulting in under diagnosing of intermittent AF. Within this work we evaluated and compared a novel miniaturized three-channel ECG monitoring patch versus a 24-h Holter ...
Loizou Christos P CP Department of Computer Science, Intercollege, P.O. Box 51604, CY-3507 Limassol, Cyprus; Cyprus University of Technology, Department of Electrical, Computer Engineering and Informatics, Limassol, Cyprus. Electronic address: - - 2014
The objective of this study was to investigate differences in intima-media thickness (IMT) and diameter (D) measurements of the common carotid artery (CCA) in ultrasound imaging in normal subjects and renal failure disease (RFD) patients. Manual measurements by two experts and automated segmentation measurements (based on snakes and active contour ...
Boskovic Aleksandra A Department of Gastroenterology and Hepatology, Mother and Child Health Care Institute, Faculty of Medicine, University of Belgrade, Serbia. Electronic address: - - 2014
Current predictive severity scores for pediatric acute pancreatitis are either extrapolated from adult studies or difficult to use in practice. The aim of this study was to assess the value of the plasma D-dimer level as a marker of severity and outcome in pediatric AP. 36 patients (aged 1-17 yrs) with ...
Kleber M E - - 2014
Algorithms to predict the future long-term risk of patients with stable coronary artery disease (CAD) are rare. The VIenna and Ludwigshafen CAD (VILCAD) risk score was one of the first scores specifically tailored for this clinically important patient population. The aim of this study was to refine risk prediction in ...
Cai Xiaoling X Endocrinology and Metabolism Department, Peking University People's Hospital, Beijing, - - 2014
This work aimed to compare the efficacy of dipeptidyl peptidase-IV (DPP-4) inhibitors and their impact on β-cell function in Asian and Caucasian patients with type 2 diabetes mellitus. Databases were systematically searched and qualifying studies that compared DPP-4 inhibitors with other antidiabetic medications in type 2 diabetes were included. A ...
Bidikar Mukta Pritam MP Assistant Professor, Department of Physiology, Topiwala National Medical College & BYL Nair Charitable Hospital , Mumbai, India - - 2014
Dysautonomia and non-motor symptoms (NMS) in Parkinson's disease (PD) are frequent, disabling and reduce quality of life of patient. There is a paucity of studies on autonomic dysfunction in PD in Indian population. The study aimed to evaluate autonomic dysfunction in PD patients and co-relate the findings with severity of ...
Choy Bonita B *Department of Dermatology, Westmead Hospital, Sydney, Australia; †Sydney Medical School, The University of Sydney, Sydney, Australia; and ‡Department of Tissue Pathology and Diagnostic Oncology, Pathology West, Institute of Clinical Pathology and Medical Research, Westmead, Sydney, - - 2014
: Panniculitis is a rare complication of BRAF inhibitor therapy that is used to treat patients with BRAF-mutated metastatic melanoma. We present a clinicopathologic review of 9 patients who developed panniculitis while on BRAF inhibitor therapy. In 13% of patients on vemurafenib, 3% of patients on dabrafenib and 10% on ...
Urner-Bloch U U Private ophthalmic practice in cooperation with the Skin Cancer Unit, University Hospital Zurich, Zurich, - - 2014
Melanoma is one of the most aggressive skin cancers. Recently, selective MEK inhibitors have shown efficacy in patients with advanced BRAF- and NRAS-mutant melanoma. Soon after the initiation of clinical oncology trials with MEK inhibitors, it was observed that some participants developed an eye condition resembling central serous chorioretinopathy. The ...
González-Baeza Alicia A HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Paseo de la Castellana 261, 28046, Madrid, Spain, - - 2014
It is unknown if, compared to a triple drug antiretroviral therapy, boosted protease inhibitor monotherapy leads to worse results in specific neuropsychological processes. In our study, we included patients virologically suppressed (≥1 year), on antiretroviral therapy, without concomitant major neurocognitive confounders, receiving boosted lopinavir or darunavir as monotherapy (n = 96) or as ...
Frazzoni Marzio M Digestive Pathophysiology Unit, Baggiovara Hospital, Modena, Italy. Electronic address: - - 2014
The pathophysiological mechanisms underlying proton pump inhibitor-refractory reflux oesophagitis has been scarcely studied. To assess impedance-pH parameters relevant to the pathogenesis of refractory reflux oesophagitis. Cases referred for heartburn/regurgitation refractory to high-dosage proton pump inhibitors between January 2008 and December 2012 were reviewed and subdivided into refractory oesophagitis (29 patients, ...
Manfrini Olivia O Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, - - 2014
We sought to determine the effectiveness of angiotensin-converting enzyme (ACE) inhibition and β-blocker treatment as a function of the degree of coronary artery disease (CAD) obstruction at angiography. The Evaluation of Methods and Management of Acute Coronary Events registry enrolled patients who had been hospitalized for an acute coronary syndrome. ...
Ebrahimzadeh Mohammad H MH Mohammad H Ebrahimzadeh MD, Hadi Makhmalbaf MD, Ali Birjandinejad MD, Farideh Golhasani keshtan MS, Hosein Asghar Hoseini MD, Seyed Mahdi Mazloumi MD, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences , Ahmad-abad St,Mashhad, 91799-9199 - - 2014
Osteoarthritis of the knee is the most common chronic joint disease that involves middle aged and elderly persons. There are different clinical instruments to quantify the health status of patients with knee osteoarthritis and one example is the WOMAC score that has been translated and adapted into different languages. The ...
de Oliveira Fabricio Ferreira FF Departments of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil Departments of Morphology and Genetics, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo, SP, - - 2014
Controversy over benefits of angiotensin-converting enzyme inhibitors (ACEIs) for treatment of dementia due to Alzheimer's disease (AD) led to this alternative investigational approach by the employment of pharmacogenetic methods, correlating the cognitive change of patients with late-onset AD with the presence of common ACE gene promoter polymorphisms, and stratifying the ...
Mroczko Barbara B Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland Department of Biochemical Diagnostics, University Hospital in Białystok, Białystok, - - 2014
A growing body of evidence shows the involvement of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in neurodegeneration processes, but reports of their concentrations in the cerebrospinal fluid (CSF) are inconsistent. Therefore, the aim of our study was to evaluate the CSF concentrations of MMP-2, MMP-3, MMP-9, and their ...
Chen John J JJ Department of Ophthalmology and Visual Science, University of Iowa, Iowa City, - - 2014
To evaluate whether carbonic anhydrase inhibitors reduce the macular thickness and/or cystic spaces in patients with macular telangiectasia (MacTel) Type 2. Retrospective review of patients with nonproliferative cystoid changes associated with MacTel seen at the University of Iowa between 2009 and 2012. Carbonic anhydrase inhibitors were used in 8 patients ...
Doerner M M Bayer HealthCare, Leverkusen, - - 2014
Background: In experimental autoimmune encephalomyelitis, inhibition of the renin-angiotensin system with angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors resulted in a significantly ameliorated disease course. We evaluated the effects of ARBs and ACE inhibitors on the efficacy of interferon beta-1b in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: ...
Luna-Záizar H H CUCEI, Universidad de Guadalajara, Guadalajara, Jalisco, México; Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, - - 2014
In Mexico, 15% of haemophilia A (HA) patients develop inhibitory alloantibodies in response to replacement therapy with factor VIII (FVIII), requiring bypass therapy such as activated prothrombin complex concentrate (APCC). Because bypass therapy has not been broadly available in Mexico even in recent years, this study aimed to evaluate the ...
Chae Young Kwang YK Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of - - 2014
Arterial and venous thrombosis may share common pathophysiology involving the activation of platelets and inflammatory mediators. A growing body of evidence suggests prothrombotic effect of renin angiotensin system (RAS) including vascular inflammation and platelet activation. We hypothesized that the use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers ...
Orlando Roy C RC University of North Carolina at Chapel Hill, Chapel Hill, N.C., - - 2014
Background/Aims: Endoscopic radiofrequency ablation of dysplastic Barrett's esophagus (BE) combined with proton pump inhibitor therapy is commonly utilized for preventing progression of dysplastic BE to esophageal adenocarcinoma. Fundamental to the success of this and all ablative approaches is the healing of the ablated areas of BE with a stratified squamous ...
Hirjak Dusan D Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg , Heidelberg , - - 2014
Neurological abnormalities including a variety of subtle deficits such as discrete impairments in sensory integration, motor coordination (MOCO), and sequencing of complex motor acts are frequently found in patients with schizophrenia (SZ) and commonly referred to as neurological soft signs (NSS). Asperger-syndrome (AS) is characterized by sensory-motor difficulties as well. ...
Janssens Xavier X Department of Rheumatology, Ghent University Hospital, Ghent, - - 2014
This study investigated whether the Health Assessment Questionnaire (HAQ) can be used as an instrument to assess the need for social support measures that address activity limitations and participation issues in patients with rheumatoid arthritis (RA). This multicenter observational study included patients with RA and disease duration of at least ...
Ghazi Payam P Department of Pediatrics, Baylor College of Medicine, Houston, TX, - - 2013
This retrospective study aimed to compare systolic and diastolic blood pressures between patients with acute kidney injury (AKI) after initiation of angiotensin-converting enzyme (ACE) inhibitor therapy and those of patients who do not experience AKI after ACE inhibitor therapy. Of 332 patients who received an ACE inhibitor as inpatients at ...
Tagariello Giuseppe - - 2013
The natural history of inhibitors in patients with haemophilia A not undergoing immune tolerance induction (ITI) is largely unknown. A recent randomized controlled trial suggests that the higher the FVIII dose used for ITI, the faster the clearance and the lower the rate of bleeding, without any difference in the ...
Jankun Jerzy - - 2013
This review summarizes our current knowledge of plasminogen activator inhibitor (PAI-1) deficiency and proposes some novel treatments for this condition. PAI-1 is a fast acting inhibitor of tissue and urokinase plasminogen activators (tPA and uPA). PAI-1 controls/slows clot lysis triggered by tPA activated plasminogen. PAI-1 deficiency was once considered to ...
Chéhensse Clément - - 2013
BACKGROUNDAfter spinal cord injury (SCI), most men cannot ejaculate without medical assistance. A major advance in the knowledge of the spinal control of ejaculation has been achieved with the discovery of a spinal generator of ejaculation (SGE) in the rat. The aim of this report was to review studies about ...
Oliveira Rodrigo Bueno de - - 2013
Vascular calcification (VC), an independent and strong predictor of cardiovascular risk, is often found in CKD patients. The degree of VC is providing incremental prognostic value over traditional risk markers. There is interest in improving our understanding of mechanisms, establishing diagnostic methods and effective prevention and treatment modalities. The abnormal ...
Jamnitski Anna - - 2013
OBJECTIVE: We investigated changes in high-density lipoprotein (HDL) profiling in patients with rheumatoid arthritis who started treatment by taking tumor necrosis factor (TNF) inhibitors. The patients were stratified for European League Against Rheumatism (EULAR) response. METHODS: A group of 100 patients naive for TNF inhibitors at baseline were randomly selected ...
Santimaleeworagun Wichai - - 2013
Atazanavir is one highly active antiretroviral therapy for naïve patients or patients with previous regimen failure. However, it seems that the protease inhibitor induces hyperlipidemia. Hyperbillirubinemia is the most common clinical adverse events but reports of cardiotoxicity due to atazanavir are scarce. The authors report a patient who had QT ...
Rossetti L C - - 2013
Inhibitor development against exogenous factor VIII is a severe impairment of replacement therapy affecting 18% of Argentine patients with severe haemophilia A (HA). To study the molecular predisposition for inhibitor development, we genotyped 260 HA patients with and without inhibitors, countrywide. The inhibitor-positive population (19 transients, 15 low responders, LR ...
Poritz Lisa S - - 2013
INTRODUCTION: Bacteria have been implicated in the development of pouchitis after ileal pouch anal anastomosis. The change in gastric pH with the use of proton pump inhibitors and H2 antagonists may lead to alteration of enteric bacteria. We hypothesized that chronic use of these medications would decrease the incidence of ...
Phé Véronique - - 2013
To assess the involvement of connexins (Cxs) 43 and 45 in the selective inhibition of detrusor contractions in patients with neurogenic detrusor overactivity (NDO). Detrusor strips with and without mucosa were obtained from patients undergoing cystectomy for either neurogenic bladder with NDO refractory to pharmacologic treatment or bladder cancer with ...
Crickx Etienne - - 2013
Dipeptidyl peptidase-4 (DPP4) inhibitors are a novel therapy widespread used in type 2 diabetes mellitus. We describe 3 cases of polyarthritis which delay of appearance strongly suggests a link with DPP4 inhibitors. Three patients presented with bilateral, symmetrical, seronegative polyarthritis after introduction of DPP4 inhibitors (sitagliptine (n = 2) and vildagliptine (n = 1)). ...
Knudtzen Fredrikke C - - 2013
Rivastigmine transdermal patch is indicated for patients with Alzheimer's disease and dementia with Parkinson's disease. Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly involving the gastrointestinal tract, but few cardiovascular adverse effects have been reported. This report presents two cases of patients presenting with 3(rd) degree atrioventricular block. ...
Kahrilas Peter J - - 2013
Treatment modalities for gastro-oesophageal reflux disease (GORD) mirror the pathophysiology of the disease. Since acid plays a key role in GORD-associated mucosal lesions, proton pump inhibitors (PPIs) are the dominant GORD treatment, being the most potent inhibitors of acid secretion available. However, the clinical effectiveness of PPIs varies with the ...
Wang An Jiang - - 2013
Up to 40% of patients with gastroesophageal reflux disease fail to respond to proton pump inhibitor therapy. To determine predictors of clinical response of proton pump inhibitor therapy. Consecutive patients with gastroesophageal reflux disease were enrolled prospectively. All patients underwent upper endoscopy and 24-h multichannel intraluminal impedance and pH monitoring ...
Lang Chim C - - 2013
The renin-angiotensin-aldosterone system is a well-established therapeutic target in the treatment of heart failure (HF). Substantial advances have been made with existing agents-angiotensin-converting enzyme (ACE) inhibitors, angiotensin II-receptor blockers (ARBs), and mineralocorticoid-receptor antagonists (MRAs)-and new data continue to emerge. The indication for the use of MRAs has been broadened to ...
Dubey Anju - - 2013
Apart from inhibitor development in patients with hemophilia (PWH) the old problems of blood borne viral infections and red cell alloimmunization still persist in PWH from developing countries. This study was planned to detect the presence of inhibitors in our PWH and to determine the presence of transfusion transmitted infections ...
Jamaati Hamid Reza HR Tobacco Prevention and Control Research - - 2013
The burden of chronic obstructive pulmonary disease (COPD) is quite high and its prevalence is increasing. We aimed to evaluate the correlation of COPD severity according to the American Thoracic Society (ATS) criteria with spirometric measurements in patients admitted to the emergency ward. In this cross-sectional descriptive study, 50 randomly ...
Sigari Naseh N Department of Internal Medicine, Kurdistan University of Medical Sciences, Sanandaj, - - 2013
Local and systemic inflammation occur at the same time in asthma and high sensitive CRP may play a role in the pathogenesis of this disease. Conventional approaches to monitor and control asthma involve no direct assessment of airway inflammation. There are some recent data postulating a discrepancy between the markers ...
Kang Kwi Young - - 2013
To determine the longitudinal effects of TNF inhibitors on BMD and radiographic progression in patients with AS and to assess independent factors associated with increased BMD in the lumbar spine. Sixty-three patients with AS were included. Twenty-six patients were treated with TNF inhibitors and 37 were not. BMD in the ...
Persson Frederik - - 2012
For approximately six years, the only commercially available direct renin inhibitor aliskiren, which inhibits the renin-angiotensin-aldosterone system at the initial rate limiting step, has been marketed for the treatment of hypertension. Concurrently, much attention has been given the possibility that renin inhibition could hold potential for improved treatment in patients ...
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