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Santimaleeworagun Wichai - - 2013
Atazanavir is one highly active antiretroviral therapy for naïve patients or patients with previous regimen failure. However, it seems that the protease inhibitor induces hyperlipidemia. Hyperbillirubinemia is the most common clinical adverse events but reports of cardiotoxicity due to atazanavir are scarce. The authors report a patient who had QT ...
Rossetti L C - - 2013
Inhibitor development against exogenous factor VIII is a severe impairment of replacement therapy affecting 18% of Argentine patients with severe haemophilia A (HA). To study the molecular predisposition for inhibitor development, we genotyped 260 HA patients with and without inhibitors, countrywide. The inhibitor-positive population (19 transients, 15 low responders, LR ...
Poritz Lisa S - - 2013
INTRODUCTION: Bacteria have been implicated in the development of pouchitis after ileal pouch anal anastomosis. The change in gastric pH with the use of proton pump inhibitors and H2 antagonists may lead to alteration of enteric bacteria. We hypothesized that chronic use of these medications would decrease the incidence of ...
Phé Véronique - - 2013
To assess the involvement of connexins (Cxs) 43 and 45 in the selective inhibition of detrusor contractions in patients with neurogenic detrusor overactivity (NDO). Detrusor strips with and without mucosa were obtained from patients undergoing cystectomy for either neurogenic bladder with NDO refractory to pharmacologic treatment or bladder cancer with ...
Crickx Etienne - - 2013
Dipeptidyl peptidase-4 (DPP4) inhibitors are a novel therapy widespread used in type 2 diabetes mellitus. We describe 3 cases of polyarthritis which delay of appearance strongly suggests a link with DPP4 inhibitors. Three patients presented with bilateral, symmetrical, seronegative polyarthritis after introduction of DPP4 inhibitors (sitagliptine (n = 2) and vildagliptine (n = 1)). ...
Knudtzen Fredrikke C - - 2013
Rivastigmine transdermal patch is indicated for patients with Alzheimer's disease and dementia with Parkinson's disease. Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly involving the gastrointestinal tract, but few cardiovascular adverse effects have been reported. This report presents two cases of patients presenting with 3(rd) degree atrioventricular block. ...
Kahrilas Peter J - - 2013
Treatment modalities for gastro-oesophageal reflux disease (GORD) mirror the pathophysiology of the disease. Since acid plays a key role in GORD-associated mucosal lesions, proton pump inhibitors (PPIs) are the dominant GORD treatment, being the most potent inhibitors of acid secretion available. However, the clinical effectiveness of PPIs varies with the ...
Wang An Jiang - - 2013
Up to 40% of patients with gastroesophageal reflux disease fail to respond to proton pump inhibitor therapy. To determine predictors of clinical response of proton pump inhibitor therapy. Consecutive patients with gastroesophageal reflux disease were enrolled prospectively. All patients underwent upper endoscopy and 24-h multichannel intraluminal impedance and pH monitoring ...
Lang Chim C - - 2013
The renin-angiotensin-aldosterone system is a well-established therapeutic target in the treatment of heart failure (HF). Substantial advances have been made with existing agents-angiotensin-converting enzyme (ACE) inhibitors, angiotensin II-receptor blockers (ARBs), and mineralocorticoid-receptor antagonists (MRAs)-and new data continue to emerge. The indication for the use of MRAs has been broadened to ...
Dubey Anju - - 2013
Apart from inhibitor development in patients with hemophilia (PWH) the old problems of blood borne viral infections and red cell alloimmunization still persist in PWH from developing countries. This study was planned to detect the presence of inhibitors in our PWH and to determine the presence of transfusion transmitted infections ...
Jamaati Hamid Reza HR Tobacco Prevention and Control Research - - 2013
The burden of chronic obstructive pulmonary disease (COPD) is quite high and its prevalence is increasing. We aimed to evaluate the correlation of COPD severity according to the American Thoracic Society (ATS) criteria with spirometric measurements in patients admitted to the emergency ward. In this cross-sectional descriptive study, 50 randomly ...
Sigari Naseh N Department of Internal Medicine, Kurdistan University of Medical Sciences, Sanandaj, - - 2013
Local and systemic inflammation occur at the same time in asthma and high sensitive CRP may play a role in the pathogenesis of this disease. Conventional approaches to monitor and control asthma involve no direct assessment of airway inflammation. There are some recent data postulating a discrepancy between the markers ...
Kang Kwi Young - - 2013
To determine the longitudinal effects of TNF inhibitors on BMD and radiographic progression in patients with AS and to assess independent factors associated with increased BMD in the lumbar spine. Sixty-three patients with AS were included. Twenty-six patients were treated with TNF inhibitors and 37 were not. BMD in the ...
Lustenberger T - - 2012
INTRODUCTION: The thrombin-activatable fibrinolysis inhibitor (TAFI) is a potent inhibitor of fibrinolysis. However, the time course of TAFI and its activated form (TAFIa) following trauma, in particular in patients suffering trauma-induced coagulopathy, has been poorly examined. METHODS: A total of 26 severely injured trauma patients were prospectively enrolled. TAFI and ...
Mammoser Aaron - - 2012
Calcineurin inhibitor encephalopathy (CIE) is a rare condition occurring in patients who are undergoing treatment with drugs from the calcineurin inhibitor (CI) family of immunosuppressants, either cyclosporine (CsA) or tacrolimus (TAC, FK506). Generally acute in onset, the symptoms are commonly reversible if properly managed in a timely fashion. The differential ...
Spatz Christin - - 2012
The incidence of contrast-induced nephropathy (CIN) ranges between 10% and 50% among high-risk patients. Whether medications that affect rennin-angiotensin-aldosterone system (RAAS) have any impact on the development of CIN remains uncertain. We performed a retrospective study of patients with CKD stages 3 and 4 who were either on or off ...
Kavutharapu Srimanjari - - 2012
Chronic pancreatitis (CP) is the progressive and irreversible destruction of the pancreas characterized by the permanent loss of endocrine and exocrine function. Trypsin, the most important digestive enzyme plays a central role in the regulation of all other digestive enzymes. Chymotrypsin, an endopeptidase hydrolyzes peptides at amino acids with aromatic ...
Boyd Kevin P KP Department of Dermatology, University of Birmingham at Alabama, Birmingham, Alabama 35294-0009, - - 2012
Nonmalignant cutaneous findings associated with the use of vemurafenib have only recently been described in the literature. Patients receiving vemurafenib have exhibited cutaneous reactions including prominent follicular plugging, hand-foot skin reaction, exuberant seborrheic dermatitis-like hyperkeratosis of the face, keratosis pilaris, and diffuse spiny follicular hyperkeratosis. Many of these nonmalignant cutaneous ...
Marcos Carmen - - 2012
A new variant of hereditary angioedema has been reported during the last decade. Three main characteristics distinguish it from classic hereditary angioedema: normal C1 inhibitor activity, predominance in women, and different genetic alterations. To assess the symptoms, laboratory findings, and treatment of a population with type III hereditary angioedema from ...
Baudouin Christophe - - 2012
Purpose. To determine the prevalence of ocular surface diseases and identify risk factors in a population of patients receiving antiglaucomatous eyedrops over the long term. Methods. An observational cross-sectional study was designed to investigate ocular surface signs and symptoms using simple clinical tools. An ocular surface disease intensity score was ...
Al-Hallaq H - - 2012
Purpose: We investigated the accuracy of surface matching compared to kV positioning of 10 post-mastectomy chestwall patients receiving inverse-planned, non-gated IMRT. Methods: During 130 treatment sessions, non-gated 3D surfaces were captured using AlignRT (v4.5) before and after table translations as indicated by kV imaging. Surfaces were compared to a reference ...
Ws Coriolano Maria das Graças - - 2012
Our goal was to study deglutition of Parkinson's disease (PD) patients and normal controls (NC) using surface electromyography (sEMG). The study included 15 patients with idiopathic PD and 15 age-matched normal controls. Surface electromyography was collected over the suprahyoid muscle group. Conditions were the following: swallow at once 10 and ...
Claude-Desroches M - - 2012
PURPOSE: To describe the characteristics of reversible focal pleural thickenings (PTs) mimicking real plaques, that firstly suggest asbestos exposure or pleural metastasis; to propose an imaging strategy and propose an explanation for their mechanism of formation. PATIENTS AND METHODS: Retrospective review of data from 19 patients with PTs fitting the ...
Brigo Francesco - - 2012
We systematically reviewed the literature to evaluate the prevalence of phosphenes and the phosphene threshold (PT) values obtained during single-pulse transcranial magnetic stimulation (TMS) in adults with migraine. Controlled studies measuring PT by single-pulse TMS in adults with migraine with or without aura (MA, MwA) were systematically searched. Prevalence of ...
Zheng Xuhai - - 2012
We developed a new method for immobilization of the fix lower extremities by using a thermoplastic mask, a carbon fiber base plate, a customized headrest, and an adjustable angle holder. The lower extremities of 11 patients with lower extremity tumors were immobilized by this method. CT simulation was performed for ...
Papathanasiou Eleftherios S - - 2011
OBJECTIVE: To compare disposable and reusable single fiber needle recordings in relation to stimulated single fiber studies. METHODS: At least 10 potentials were sampled using each needle type from each patient with a minimum of 20 sampled potentials per patient. For successive patients either a disposable or reusable electrode was ...
Singh Arun - - 2011
Bradykinesia and hypokinesia are the prominent symptoms of substantia nigra degeneration in Parkinson's disease (PD). In segmental dystonia, movements of not affected limbs are not impaired. Here we studied the impact of the mere implantation of stimulation electrodes on the performance of fast movements in these two groups. We investigated ...
Hamdi Wafa - - 2011
To assess the performance of ultrasound in detecting erosion, swelling, and new bone comparing to radiographs in five lower limb entheses in patients with ankylosing spondylitis (AS). Prospective study of 60 patients meeting modified New York criteria for AS. Lateral radiographs of both knees and ankles followed by a high-resolution ...
Caldwell Jane C - - 2011
AimsAtrial fibrillation (AF) is a major cause of morbidity, mortality, and health resource consumption. However, as many patients with chronic AF are asymptomatic, rapid, accurate opportunistic screening is needed in primary care to detect AF. Conventional electrocardiogram (ECG) technology is too clumsy and time consuming for mass opportunistic screening, thus ...
Le Bars H - - 2011
We prospectively assessed stool samples from 370 patients for Campylobacter species by comparing three selective agar media incubated at two temperatures: 42°C and 37°C. Twenty patients (5.4%) were found positive. The chromogenic medium CASA (AES Chemunex, France) proved highly efficient for C. jejuni and C. coli recovery, while lessening the ...
Kleine Bert U - - 2011
OBJECTIVE: To compare the prevalence of fasciculation potentials (FPs) with F-responses between patients with amyotrophic lateral sclerosis (ALS) and patients with benign fasciculations. METHODS: In seven patients with ALS and seven patients with benign fasciculations, high-density surface EMG was recorded for 15min from the gastrocnemius muscle. Template matching was used ...
Hamaneh Mehdi B - - 2011
SUMMARY: Although scalp EEG is a very useful tool for presurgical evaluation in epilepsy, the 10-20 system of electrodes in many cases fails to accurately localize the source of the epileptic seizures. One suggested solution to this problem is to use additional electrodes. Sphenoidal electrodes especially have been suggested to ...
Mahnken Andreas H - - 2011
Aortic valve calcifications (AVC) as seen on conventional chest films or on CT are associated with aortic valve stenosis (AVS). The absence of AVC on chest films does not exclude high grade AVS. The aim of this study was to analyse if there is a threshold for the detection of ...
Bilir Cemil - - 2011
INTRODUCTION:: Primary dysmenorrhea (PD), which is characterized by painful menstrual cycles, is one of the common clinical problems in young adult women. The aim of this study was to investigate the risk of cardiac arrhythmias in PD patients by using the electrocardiographic (ECG) parameters. METHODS:: Forty patients diagnosed with PD ...
Hoffmann Michael B - - 2011
Recently, it has been suggested that misprojections of the temporal retina to the contralateral hemisphere might not be specific for patients with albinism and might also be associated with the Kartagener syndrome (i.e., with situs inversus totalis in the presence of primary ciliary dyskinesia [PCD]). The authors tested whether such ...
Kawaguchi Tetsuro - - 2011
BACKGROUND: We prospectively evaluate the role of computerized tomographic cisternography (CTC) in idiopathic normal pressure hydrocephalus (iNPH). METHODS: The cerebrospinal fluid kinetics of 70 patients who passed the entry criteria for the Study of iNPH on Neurological Improvement (SINPHONI) and underwent insertion of a shunt were studied. RESULTS: Stasis of ...
Bejdová Sárka - - 2011
Bilateral complete cleft lip and palate (BCLP) is the most severe of the common orofacial clefts and is associated with the greatest deformity during development. The aim of this study was to use geometric morphometrics to evaluate palatal shape and size variability in patients with BCLP in comparison to nonclefted ...
Britsemmer Karin - - 2011
Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA). To evaluate the diagnostic and discriminative ability of these new criteria compared with the 1987 ACR criteria and the Visser decision rule. 455 patients with early arthritis were studied. The ...
Anderson James R - - 2011
BACKGROUND: Loss of sensory function in scar after burn is common, although the basis for this loss is not clear. Additionally, little is known about the effects of different treatment modalities on sensory function and neuroanatomical outcomes in burn patients. Here, we investigated the effects of the use of the ...
Gökçay Figen F Department of Neurology, Ege University Medical School, Bornova, ─░zmir, Turkey. - - 2011
To assess the clinical patterns of neurologic involvement and the frequencies and characteristics of different types of headaches in patients with Behçet disease. Total 530 patients with Behçet disease were evaluated for the presence of neurologic involvement and/or headache. Of the 54 patients (10.2%) with neurological involvement, 36 (66.7%) had ...
Lin Chi-Maw - - 2011
Abstract Conclusion. The inner ear monitoring system is useful for identifying the affected branches of the vestibular nerve in cases of vestibular neuritis, providing insight about the interval for the relief of vertigo. Objective: This study conducted an inner ear monitoring system including audiometry, and caloric, ocular vestibular evoked myogenic ...
Taskaynatan Mehmet A - - 2011
Although the use of ultrasound (US) to perform suprascapular nerve block (SsNB) is rapidly gaining popularity, information about its accuracy is still lacking. The aim of this study was to investigate the proximity of the needle to suprascapular nerve under US guidance by means of neurostimulation current intensity in SsNB. ...
Ekstrand Ylva - - 2011
Background. Increasing evidence points to a potential role for members of the transient receptor potential family of cation channels on several features of asthmatic disease. The cough sensitivity to inhaled capsaicin is known to reflect the reactivity of these airway sensory nerves. Objective. The aim was to study, among patients ...
Singh Dilip - - 2011
OBJECTIVE: Spirometry is the most common test recommended to monitor respiratory dysfunction in patients of amyotrophic lateral sclerosis (ALS). However, the test depends on the patient's efforts and may be difficult to conduct in patients with faciobulbar weakness. We aimed to study the role of phrenic nerve-electrophysiological studies to predict ...
Rowe F - - 2011
Occurrence of ocular motor cranial nerve palsies (OMCNP), following stroke, has not been reported in relation to the type of OMCNP seen and in relation to brain area affected by stroke. The aim of this study was to identify all patients referred with suspected visual impairment to establish the presence ...
Kästel T - - 2011
BACKGROUND AND PURPOSE: MRN is an emerging diagnostic method for disorders of peripheral nerves. However, it is unclear whether the influence of the MA on intraneural T2 signal is severe enough to provoke false-positive findings. MATERIALS AND METHODS: Twenty-five healthy subjects underwent MRN of the sciatic nerve of the proximal ...
Koike Haruki - - 2011
Transthyretin (TTR) Val30Met-associated familial amyloid polyneuropathy (FAP ATTR Val30Met) is the most common form of FAP and is now prevalent in areas other than those seen within conventional endemic foci. We investigated 15 patients with FAP ATTR Val30Met without a family history of FAP who were referred for sural nerve ...
Hansson Emma - - 2011
Abstract Dercum's disease is characterised by pronounced pain in the adipose tissue and a number of associated symptoms and is, in most patients, accompanied by obesity. Postoperative sensory change after liposuction is a well-known side effect, and probably caused by mechanical trauma to the nerves. The aim of this investigation ...
Taneda K - - 2011
Background:  Psoriasis is a complex, multifactorial inflammatory skin disease with genetic and environmental interactions. Patients with psoriasis exhibit erythematous plaques with itch, but the mechanisms of psoriatic itch are poorly understood. Objectives:  This study was performed to investigate epidermal nerve density and opioid receptor levels in psoriatic skin with or ...
Tang Hao - - 2011
Objective: To discuss the method of functional reconstruction of ischemic contracture in the lower limb and propose a classification protocol for ischemic contracture in the lower limb based on its severity and prognosis. Methods: A total of 42 patients with ischemic contracture in the lower limb were included in this ...
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