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Stojiljkovic Maja - - 2014
Abstract Hyperphenylalaninemia (HPA) [phenylketonuria (PKU) and tetrahydrobiopterin (BH4) deficiencies] is rare inborn metabolic disease characterized by elevated phenylalanine level in body fluids. In Serbia, 62 HPA patients have been identified through newborn screening since 1983. However, pterin pattern analysis is not performed. We present a patient initially diagnosed and treated ...
Gonçalves Cristina C Cristina Gonçalves, Ana Isabel Lopes, Gastroenterology Unit, Pediatric Department, University Hospital Santa Maria, Lisbon Academic Medical Centre, 1649-035 Lisboa, - - 2014
To characterize clinical, laboratorial, and histological profile of pediatric autoimmune gastritis in the setting of unexplained iron deficiency anemia investigation. A descriptive, observational study including pediatric patients with a diagnosis of autoimmune gastritis (positive parietal cell antibody and gastric corpus atrophy) established in a 6 year period (2006-2011) in the ...
Khajeh L L Department of Neurology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The - - 2014
We describe the occurrence and course of anterior pituitary dysfunction (PD) after aneurysmal subarachnoid haemorrhage (SAH), and identify clinical determinants for PD in patients with recent SAH. We prospectively collected demographic and clinical parameters of consecutive survivors of SAH and measured fasting state endocrine function at baseline, 6 and 14 months. ...
Suzuki Etsu E Etsu Suzuki, Institute of Medical Science, St. Marianna University School of Medicine, Miyamae-ku, Kawasaki 216-8512, - - 2014
Erectile dysfunction (ED) is a common condition among male chronic kidney disease (CKD) patients. Its prevalence is estimated to be approximately 80% among these patients. It has been well established that the production of nitric oxide from the cavernous nerve and vascular endothelium and the subsequent production of cyclic GMP ...
Morrison Belinda F BF Department of Surgery, University of the West Indies, Mona, - - 2014
The purpose of this study was to determine the association of testosterone deficiency and priapism in adult men with sickle cell disease (SCD). A cross-sectional study of 50 adult men with SCD (hemoglobin SS) was performed. All patients had early morning blood taken for total and free testosterone, FSH, LH, ...
Bruns Juergen J Department of Orthopaedic Surgery, Agaplesion Diakonieklinikum, Hohe Weide 17, 20259, Hamburg, Germany, - - 2014
The aetiology of osteochondritis dissecans is still unclear. The aim of this prospective pilot study was to analyse whether vitamin D insufficiency, or deficiency, might be a contributing etiological factor in the development of an OCD lesion. The serum level of vitamin D3 in 23 consecutive patients (12 male and ...
Aktas G G Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, - - 2014
Hashimoto's Thyroiditis (HT) is the most common autoimmune thyroiditis worldwide and characterized with lymphomonocytic inflammation of the thyroid gland. Red cell distribution width (RDW) reflects erythrocyte anisocytosis and besides it increases in iron deficiency anemia, recent studies reported that RDW was also associated with conditions characterized with overt or subclinical ...
Aldave Adrian P - - 2014
Hypercalcemia is one of the most common metabolic abnormalities encountered in any form of malignancy. Hypocalcemia, however, is a rare manifestation, especially in cancers with bone involvement. Here we present a case of hypocalcemia in a patient with multiple myeloma that was refractory to treatment. A 73-year-old African American woman ...
Bertoli Luigi F - - 2014
BackgroundOur informal observations suggested that some patients with acute sensorineural hearing loss (ASNHL) have subnormal serum immunoglobulin (Ig) levels. We evaluated 28 consecutive adults (18 men, 10 women) at ASNHL diagnosis using: antibodies to 68 kD protein, 30 kD protein, and type II collagen; and serum total IgG, IgG subclasses, ...
Magner Martin M Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 2, 12808, Prague 2, Czech - - 2014
TMEM70 deficiency is the most common nuclear-encoded defect affecting the ATP synthase. In this multicentre retrospective study we characterise the natural history of the disease, treatment and outcome in 48 patients with mutations in TMEM70. Eleven centers from eight European countries, Turkey and Israel participated. All 27 Roma and eight ...
Lahner Edith E Department of Digestive and Liver Disease, Sant'Andrea Hospital, Medical School, Sapienza University , Rome , - - 2014
Abstract Objective. Data on clinical presentation and associated features of patients with type 1 gastric carcinoids (T1-GCs) are scanty. This study aimed to provide detailed data on a series of patients with T1-GCs. Material and Methods. Clinical, laboratory, endoscopic, and histological data were assessed from 31 T1-GCs patients (cross-sectional design), ...
Bilici Ahmet A Department of Medical Oncology, Medical Faculty, Istanbul Medipol University, Tem Avrupa Otoyolu Goztepe Cıkısı, No: 1, Bagcilar, 34214, Istanbul, Turkey, - - 2014
After total (TG) or distal subtotal gastrectomy (DG), patients are at high risk of vitamin B12 (vit-B12) deficiency, which results in elevation of homocysteine levels. The changing of serum vit-B12 and homocysteine levels in patients with gastric cancer is not well known. Seventy-two patients with gastric cancer who had undergone ...
Ahluwalia Jasmina J Departments of *Hematology and †Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India; and ‡Department of Ophthalmology, Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2014
To study the thrombotic factors, namely deficiencies of plasma proteins C, S, and antithrombin, factor V Leiden mutation, and positivity for antiphospholipid antibodies in young patients with retinal vein occlusion. The thrombophilia parameters listed above were analyzed from the laboratory records of 50 patients with the clinical diagnosis of retinal ...
Naderi Majid M Departement of Pediatric Hematology and Oncology, Ali Ebn-e Abitaleb Hospital, Research Center for Children and Adolescent Health (RCCAH), Zahedan University of Medical Sciences, Zahedan, - - 2014
Background: Factor V deficiency (FVD) is a rare bleeding disorder (RBD) mostly present in regions with a high rate of consanguinity. FVD after FXIII deficiency is the next more prevalent RBD in Sistan and Baluchistan (S&B) in southeastern Iran. The aim of this study was to evaluate the clinical manifestations ...
Schiller Adalbert A Department of Nephrology, University of Medicine and Pharmacy "V. Babes" Timisoara, Timisoara, - - 2014
Vitamin D deficiency is still a common problem particularly in the elderly and in individuals with various degrees of renal impairment. The present study aimed to evaluate the association between plasma concentrations of 25(OH)D and death in a large cohort of prevalent patients on hemodialysis (HD) from south-east Romania, a ...
Cohen-Solal Alain A UMR-S 942, Université Paris Diderot, DHU FIRE, Department of Cardiology, Lariboisière Hospital, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France. Electronic address: - - 2014
The prevalence of iron deficiency is high -even in the absence of anaemia- in patients with chronic heart failure (HF). Although iron deficiency is easily diagnosed with two biomarkers (serum ferritin and transferrin saturation), it is underdiagnosed in patients with HF. Iron is not only necessary for red blood cells, ...
Beguin Yves Y University Hospital of Liège , Avenue de l'Hopital1, B-4000 Liège , Belgium +32 43 66 72 01 ; +32 43 66 88 55 ; - - 2014
Introduction: Iron is a key element in the transport and utilization of oxygen and a variety of metabolic pathways. Iron deficiency is a major cause of anemia and can be associated with fatigue, impaired physical function and reduced quality of life. Administration of oral or intravenous (i.v.) iron is the ...
Rech Megan A MA Megan A. Rech, Todd Hunsaker, and Jennifer Rodriguez are clinical pharmacists, critical care, Department of Pharmacy Services, Henry Ford Hospital, Detroit, Michigan. - - 2014
Vitamin D has immunomodulating properties. To determine if vitamin D deficiency within 30 days of admission to the intensive care unit in patients with sepsis might be associated with increased all-cause 30-day mortality. In a retrospective cohort study at a large, tertiary, urban, academic medical center, records of patients who ...
Ngai Melissa - - 2014
Background: Vitamin D deficiency is associated with secondary yperparathyroidism and mineral and bone disorder (MBD) in chronic kidney disease (CKD). This study aimed to determine the prevalence of vitamin D insufficiency/deficiency, and the association between vitamin D status and MBD in a multi-ethnic CKD population in Southeast Asia. Methods: Predialysis ...
Rajsekhar Putta P Professor, Department of Medicine, Government General Hospital, Kurnool (Kurnool Medical College , Kurnool, Andra Pradesh, India - - 2014
Vitamin B12 deficiency is widespread than assumed in population. At risk are older people, pregnant women, vegans, patients with renal and intestinal diseases. Vitamin B12 deficiency can present with various hematological, gastrointestinal and neurological manifestations. In the population, the prevalence of vitamin B12 deficiency in younger people is 5% to ...
Ruge T T Department of Surgery, Umeå University , Umeå , - - 2014
Background: Rheumatoid arthritis (RA) is characterized by chronic synovitis and articular cartilage destruction. Increased activities of cathepsin S and cathepsin L, two potent cysteine proteases, are thought to play a role in the pathogenesis of the irreversible articular cartilage destruction. Nevertheless, data regarding the potential importance of the cathepsins as ...
Türkoğlu Oya O Department of Periodontology, School of Dentistry, Ege University, 35100 Izmir, - - 2014
Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases. Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized ...
Mangat Chetna C Department of Pediatrics, Hurley Children's Hospital, Flint, Michigan, - - 2014
A 2-year-old African-American male patient with sickle cell trait developed cough, red coloured urine, pallor and fatigue. The patient was hospitalised. Diagnostic workup showed that he was glucose 6 phosphate dehydrogenase (G6PD) deficient in erythrocytes. He also had chest X-ray findings of pneumonia. His urine examination showed the presence of ...
Dickson Jon Mark JM Academic Unit of Primary Medical Care, The University of Sheffield, Sheffield, - - 2014
We report a case of inadequate diet (caused by extreme self-neglect and alcohol excess) which led to chronic severe deficiencies of vitamins A, D and E. At presentation the patient had widespread follicular hyperkeratosis of the skin, keratomalacia of both eyes and a severe cognitive impairment. He responded well to ...
Hashimoto Rintaro R Department of Gastroenterology, Sendai Kosei Hospital, - - 2014
A 59-year-old man was orally administered rabeprazole, a proton pump inhibitor (PPI), for gastroesophageal reflux disease, after which he gradually developed iron-deficiency anemia. The anemia did not improve following the administration of ferrous fumarate, and endoscopic screening of the entire gastrointestinal tract, including the small intestine, did not reveal any ...
Kanamori Kenta K The Fourth Department of Internal Medicine, Teikyo University School of Medicine University Hospital, - - 2014
QT prolongation and Torsades de Pointes were observed in a 44-year-old woman who had adrenal insufficiency caused by isolated adrenocorticotropic hormone deficiency. Although she had several risk factors for QT prolongation, we concluded that the adrenal insufficiency contributed to the QT prolongation, because the electrocardiographic changes were improved after steroid ...
Mohammed Mujib Abu Syed AS Industrial Microbiology Research Division, Bangladesh Council of Scientific and Industrial Research, Chittagong 4220, - - 2014
A total of 150 (30.61%) anemic patients out of 490 patients diagnosed to have iron deficiency anemia (IDA) have been selected for the first time in Bangladesh. For detailed study, blood samples from 150 anemic patients along with 25 controls were analyzed. Analysis of variance showed significant P value between ...
Kim Ho Yeon - - 2013
Objectives. To compare the circulating levels of cathepsin D in preeclamptic and normotensive pregnancies. Design and Methods. Fifty pregnant and 20 healthy non-pregnant patients were enrolled in this study. Of the 50 pregnant patients, 15 were preeclamptic and 35 patients were normotensive. Serum levels of soluble cathepsin D were measured ...
Tooth David - - 2013
Faecal serine proteases (FSPs) may play a role in irritable bowel syndrome with diarrhoea (IBS-D), but their origin is unclear. We aimed to structurally characterise them and define the impact of colonic cleansing and transit time. Faecal samples were obtained from 30 healthy volunteers (HV) and 79 patients with IBS-D ...
Annaházi Anita - - 2013
OBJECTIVES:Luminal serine-proteases lead to increased colonic paracellular permeability and visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Other proteases, namely cysteine-proteases (CPs), increase airway permeability by digesting epithelial tight junction proteins. In this study, we focused on constipation-predominant IBS (IBS-C) and we aimed to (i) evaluate CP levels ...
Laudanski Piotr - - 2013
OBJECTIVE: To determine the concentrations of cathepsins B, D and G in proliferative eutopic endometrium of patients with and without endometriosis, by use of the surface plasmon resonance imaging (SPRI) technique. STUDY DESIGN: A total of 55 patients were recruited in the study: 31 patients with endometriosis (stages I-IV) and ...
Park Hyung-Doo - - 2012
Pancreatic ductal adenocarcinoma (PDAC) accounts for 95% of pancreatic cancers. CA19-9 is not widely used for screening PDAC due to its low sensitivity. Here, we studied the clinical usefulness of cathepsin D, matrix metalloproteinases (MMPs), and tissue inhibitors of MMPs (TIMPs) for screening patients with PDAC. A total of 248 ...
Büyüklü Mutlu - - 2012
BACKGROUND: Levosimendan is known with its two-sided effects of strengthening myofibril contraction without increasing myocardial oxygen demand. Anemia is a deteriorating situation that causes increase of drug dosing in patients with heart failure. OBJECTIVES: In this study, we compared the effectiveness of levosimendan treatment in decompensated heart failure patients with ...
Furuta Yasushi - - 2012
To investigate the biological factors related to the onset of Bell's palsy, we sought to identify differentially expressed genes in peripheral blood mononuclear cells (PBMCs) and plasma of patients with Bell's palsy and Ramsay Hunt syndrome (RHS). We carried out DNA microarray analyses using PBMCs taken from patients with Bell's ...
Sutter Reto - - 2012
To compare the alpha-angle measurements in volunteers and patients with femoroacetabular impingement (FAI) and to develop potential threshold values. This study was approved by the institutional review board; all individuals signed informed consent. Magnetic resonance (MR) images at 1.5 T in 106 individuals (ages 20-50 years) were analyzed in 53 ...
Hong L Elliot LE Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA. - - 2012
Theta-alpha range oscillations have been associated with MMN in healthy controls. Our previous studies showed that theta-alpha activities are highly heritable in schizophrenia patients' families. We aimed to test the hypothesis that theta-alpha activities may contribute to MMN in schizophrenia patients and their family members. We compared MMN and single ...
Schaeffeler Christoph - - 2012
The purpose of the study was to evaluate whether patients with clinically suspected femoroacetabular impingement (FAI) show higher epiphyseal torsion angle values on MR arthrography than healthy volunteers. Another objective was to estimate whether patients with increased epiphyseal torsion angles show a higher incidence of hip abnormalities or a higher ...
Vecchio Fabrizio - - 2012
It has been reported that GSM electromagnetic fields (GSM-EMFs) of mobile phones modulate -after a prolonged exposure- inter-hemispheric synchronization of temporal and frontal resting electroencephalographic (EEG) rhythms in normal young and elderly subjects (Vecchio et al., 2007, 2010). Here we tested the hypothesis that this can be even more evident ...
Abbruzzese Giovanni - - 2012
A patient self-rated 19-item wearing-off questionnaire (WOQ-19) was shown to be a potent screening tool for wearing-off (WO) in patients with Parkinson's disease. As part of the early detection of wearing-off in Parkinson's disease study, we preliminarily performed a linguistic and a psychometric validation of an Italian version of the ...
Ponte Filipa - - 2012
Fanconi Anemia (FA) is a rare genetic disorder, characterized by progressive bone marrow failure and increased predisposition to cancer. Despite being highly heterogeneous, all FA patients are hypersensitive to alkylating agents, in particular to 1,2:3,4-diepoxybutane (DEB), and to oxidative damage. Recent studies point to defective mitochondria in FA cells, which ...
Lehembre Rémy R Cyclotron Research Centre and Neurology Department, University Hospital of Liege, - - 2012
The aim of this study was to look for differences in the power spectra and in EEG connectivity measures between patients in the vegetative state (VS/UWS) and patients in the minimally conscious state (MCS). The EEG of 31 patients was recorded and analyzed. Power spectra were obtained using modern multitaper ...
Rusak Tomasz - - 2011
Polycythemia vera (PV) is associated with an increased frequency of thrombotic complications. This study was undertaken to evaluate the hemostatic balance in the blood of PV patients by means of thromboelastography (TEG). The effect of isovolemic erythrocytapheresis (ECP) on the hemostasis of PV patients was also studied. We assessed the ...
Fingelkurts Alexander A - - 2011
The value of resting electroencephalogram (EEG) in revealing neural constitutes of consciousness (NCC) was examined. We quantified the dynamic repertoire, duration and oscillatory type of EEG microstates in eyes-closed rest in relation to the degree of expression of clinical self-consciousness. For NCC a model was suggested that contrasted normal, severely ...
Modzelewski Romain - - 2011
High-dose (HD) cytosine arabinoside (ara-C) is a major treatment in acute myeloblastic leukemia (AML) that can lead to cerebellar complications, although electroencephalogram, computed tomography, and magnetic resonance imaging remain normal. We conducted a prospective study to evaluate brain perfusion with single-photon emission computed tomography (SPECT) in adult patients before and ...
Giaginis Constantinos - - 2011
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its nuclear partners, the Retinoid X Receptors (RXRs), have been recognized as crucial players in the pathogenesis of atherosclerosis. The present study aimed to assess the clinical significance of PPAR-gamma and RXR-alpha expression in different cellular populations localized within advanced carotid atherosclerosis lesions. PPAR-gamma and ...
Lin Yow-Sien - - 2011
Huntington disease (HD) is a degenerative disorder caused by expanded CAG repeats in exon 1 of the huntingtin gene (HTT). Patients with late-stage HD are known to have abnormal auditory processing, but the peripheral auditory functions of HD patients have yet to be thoroughly assessed. In this study, 19 HD ...
Wasay Mohammad - - 2011
The objective of this study was to evaluate the prognostic significance of neurological manifestations in falciparum malaria. We analyzed adult patients with malaria admitted from 2001 to 2003, diagnosed by asexual forms of Plasmodium falciparum in peripheral blood films and identified cases of malaria with neurological involvement. A patient was ...
de Jager Corine M - - 2010
OBJECTIVE:: To report the case of a 48-year female with chronic remitting anorexia nervosa who was found comatose at home and admitted to our hospital with a deep hypoglycemia (glucose level 0.6 mmol/L; 11 mg/dL) and septic shock secondary to a bilateral pneumonia. METHOD:: Case report. RESULTS:: After admission to ...
Dervaux Alain - - 2013
Psychomotor performance has consistently been found to be altered in chronic cannabis users. Neurological soft signs (NSS) reflect neurological dysfunction involving integrative networks, especially those involving the cerebellum, where cannabinoid receptors are particularly concentrated. Our objective was to study, for the first time, NSS in a group of patients with ...
Kavakli Havva Sahin HS Department of Emergency Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey. - - 2011
Carbon monoxide poisoning (COP) is one of the important causes of morbidity and mortality in toxicological cases. In this study, we aimed to find out more about the pathophysiology of COP by investigating the effects of COP on oxidative stress parameters such as total oxidant status (TOS) and total antioxidant ...
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