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Sandrasegaran Kumaresan K 1 Department of Radiology, Indiana University School of Medicine, 550 N University Blvd, UH 0279, Indianapolis, IN - - 2014
OBJECTIVE. T2 hyperintensity of pancreatic acini during secretin-enhanced MRCP is called "acinarization." We sought to determine the clinical significance of this finding. MATERIALS AND METHODS. Patients were selected if the radiology report included the phrases "acin*" (where * represented a wild card search) or "blush" using the institution's customized lexicon-search ...
Beland Michael D MD 1 Department of Diagnostic Imaging, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy St, Providence, RI - - 2014
OBJECTIVE. The purpose of this study was to evaluate the diagnostic accuracy of real-time shear-wave elastography for assessment of liver fibrosis in an unselected patient population, comparing shear-wave elastography measurements obtained at and remote from the site of random liver biopsy. SUBJECTS AND METHODS. In a prospective study of 50 ...
N Zekri Abdel-Rahman AR Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, - - 2014
Background and aim. DNA methylation plays a critical role in the control of important cellular processes. The present study assessed the impact of promoter methylation (PM) of some genes on the antiviral response to antiviral therapy and it's relation to the presence of fibrosis in HCV-4 infected patients from Egypt. ...
Sandberg Frida F Signal Processing Group, Department of Biomedical Engineering, Lund University, Lund, - - 2014
Intradialytic hypotension (IDH) is the most common adverse complication during hemodialysis. Its early prediction and prevention will dramatically improve the quality of life for patients with an end stage renal disease. In a recent study, changes in the normalized envelope of the test statistic of the photoplethysmograpic (PPG) signal were ...
Olson Erik J EJ From the Trauma Service, Scripps Mercy Hospital, San Diego, - - 2014
The prevention of venous thromboembolic disease following trauma is a priority. In contrast to above-knee deep vein thrombosis (AKDVT), the management of below-knee deep vein thrombosis (BKDVT) is controversial because the risk of pulmonary embolism (PE) has not been firmly established. We hypothesized that BKDVT and AKDVT have an equivalent ...
Schulert Grant S GS From the *Division of Rheumatology and †Department of Pediatrics, Vanderbilt University Medical Center, Nashville, - - 2014
Childhood obesity is an increasing public health concern, but little is known about how obesity contributes to chronic arthritis. The objective of this study was to identify and characterize children and adolescents who present with isolated arthritis of the ankle/hindfoot/midfoot complex and profound obesity. We identified all patients with juvenile ...
Parke Rachael L RL Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand. - - 2014
The optimal strategy for fluid replacement after major surgery remains unclear and there is considerable interest in the investigation of more restrictive fluid regimens. We aimed to establish current practice of fluid administration to patients after cardiac surgery. A multicentre, prospective observational study, over an 8-week period, of consecutive patients ...
C-F Ng Anthony - - 2014
Objective: BYSH, a herbal formula, was evaluated for efficacy and safety in a pilot study for patients with advanced hormone refractory prostate cancer (HRPC). Patients and Methods: The pilot study was designed as a single-center open-label trial. Patients with HRPC were treated with BYSH for 24 weeks. The primary end ...
Escher Felicitas F Department of Cardiology and Pneumology, CBF, Charité-Universitätsmedizin Berlin, Berlin, - - 2014
Intramyocardial inflammation is considered an adverse prognostic factor in inflammatory cardiomyopathy (CMi). However, the precise nature of immune system factors relevant for the prediction of long-term course remains elusive. The aim of this study was to analyse the prognostic relevance of perforin in a large cohort of patients with CMi. ...
Martínez-Quintana Efrén E 1Cardiology Service,Insular-Materno Infantil University HospitalLas Palmas de Gran - - 2014
Introduction: CHD patients, especially those with associated hypoxaemia, usually have some level of renal function impairment, even though they are relatively young. The aim of the study was to evaluate those clinical and analytical factors that may contribute to microalbuminuria and determine the association of 24-hour proteinuria with thrombotic events ...
Umemura Takeji T Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, - - 2014
Although hyponatremia is associated with a poor prognosis in liver cirrhosis, little is known about the clinical significance of serum sodium concentration in cirrhosis in Japan. This study investigated associations of mortality in Japanese cirrhosis patients taking conventional diuretics with serum sodium concentration and other clinical characteristics. A total of ...
Beumer Jan H JH Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15213, USA, - - 2014
Older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome have often been excluded from myeloablative-conditioning regimens containing busulfan because of non-disease-related morbidity and mortality. We hypothesized that busulfan clearance (BuCL) in older patients (>60 years) would be reduced compared to that in younger patients, potentially explaining observed differences in busulfan ...
Talaat Forayssa M FM 1Department of Neurology, Faculty of Medicine, Cairo University, Cairo, - - 2014
Introduction: Epilepsy is a chronic disease that affects metabolism either alone or through the antiepileptic drug (AED) treatment. A risk of atherosclerosis has been found in epileptic patients. Aim: Prove the potential role of epilepsy and/or its treatment as atherosclerotic risk factors. Subject and Methods: Forty Egyptian patients with primary ...
Kaneko Hidehiro H Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, - - 2014
Functional mitral regurgitation (MR) is frequently associated with left ventricular systolic dysfunction (LVSD). Ventricular volume overload that occurs in patients with MR may lead to a progression of myocardial dysfunction. However, the prevalence and clinical outcomes of functional MR in Japanese patients with LVSD remain unclear. The aim of the ...
Sonbol M B MB Division of Hematology, Mayo Clinic, Rochester, - - 2014
Background: Mantle cell lymphoma (MCL) is a unique type of lymphoma with a prognosis intermediate between indolent and aggressive types. The purpose of this study was to study blood cytokine levels in newly diagnosed and relapsed MCL patients with respect to patterns of abnormalities and relationship to the MCL International ...
Cornelissen Liesbeth L Radiology, Department of Imaging & Pathology, University Hospitals Leuven, KU Leuven, Herestraat 49, 3000, Leuven, Belgium, - - 2014
The purpose of this study was to retrospectively assess the incidence of bowel wall oedema on computed tomography (CT) in patients with renal cell carcinoma (RCC) treated with sunitinib, and to investigate its association with diarrhoea. We conducted a retrospective analysis of all RCC patients treated with sunitinib at our ...
Alfieri Veronica - - 2014
BackgroundWe investigated whether a relationship between small airways dysfunction and bronchial hyperresponsiveness (BHR), expressed both in terms of ease of airway narrowing and of excessive bronchoconstriction, could be demonstrated in asthma.Methods63 (36 F; mean age 42 yr¿±¿14) stable, mild-to-moderate asthmatic patients (FEV1 92% pred ±14; FEV1/FVC 75%¿±¿8) underwent the methacholine challenge test ...
Komatsu Yoshihiro Y Institute for the Treatment of Esophageal and Thoracic Disease, Allegheny Health Network, Pittsburgh, PA, - - 2014
The management of laryngopharyngeal reflux (LPR) has been challenging. Hypopharyngeal multichannel intraluminal impedance (HMII) has shown to increase the sensitivity in diagnosing LPR. The objective of this study is to investigate the potential use of pepsin and Sep70 as diagnostic tools for detection of LPR in combination with HMII. Tissue ...
Di Lello F A FA Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Avenida de Bellavista s/n., 41014, Seville, - - 2014
The aim of this study was to analyze the impact of core variations on sustained virological response (SVR) to pegylated interferon plus ribavirin (PEG-IFN/RBV) and its association with predictive factors of response in Caucasian patients infected with genotype 1 hepatitis C virus (HCV-1). Full-length core sequences were analyzed in 100 ...
Zugck Christian C Clinic/Group Practice for Internal Medicine, Steiner Thor, Straubing, Germany, - - 2014
In the prospective, open-label multicenter INTENSIFY study, the effectiveness and tolerability of ivabradine as well as its impact on quality of life (QOL) in chronic systolic heart failure (CHF) patients were evaluated over a 4-month period. In CHF patients with an indication for treatment with ivabradine, resting heart rate (HR), ...
Rogalski Emily E From the Cognitive Neurology and Alzheimer's Disease Center (E.R., A.M., C.W., S.W., M.-M.M.), and Departments of Psychiatry and Behavioral Sciences (D.C., S.W.), Preventative Medicine (A.R.), and Neurology (M.-M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL. - - 2014
The aim of this study was to provide quantitative measures of changes in cortical atrophy over a 2-year period associated with 3 subtypes of primary progressive aphasia (PPA) using whole-brain vertex-wise and region-of-interest (ROI) neuroimaging methods. The purpose was to quantitate disease progression, establish an empirical basis for clinical expectations, ...
Husain N N Department of Medicine, Baylor College of Medicine, Houston, TX, USA; Section of Gastroenterology and Hepatology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, - - 2014
In practice, nonalcoholic fatty liver disease (NAFLD) is diagnosed based on elevated liver enzymes and confirmatory liver biopsy or abdominal imaging. Neither method is feasible in identifying individuals with NAFLD in a large-scale healthcare system. To develop and validate an algorithm to identify patients with NAFLD using automated data. Using ...
Janati A Bruce AB Center for Neurology, Fairfax, VA, USA, - - 2014
There is a plethora of data in the EEG literature on the characteristics of the most prominent component of interictal epileptiform discharges (IED), namely the negative (fast) phase. Surprisingly, however, little attention has been drawn to the after-coming slow wave (ASW), and its pathological as well as clinical significance. In ...
Müller T J TJ Department of Neurology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120, Halle (Saale), - - 2014
Objective. To characterize the phenotype of patients with distal myopathy with vocal cord and pharyngeal weakness (VCPDM) due to the p.S85C mutation in the Matrin 3 gene (MATR3, MIM 164015). Recently it has been suggested that patients with this mutation may suffer from familial amyotrophic lateral sclerosis. Patients and methods. ...
Karabul Nesrin N Villa Metabolica, Centre for Pediatric and Adolescent Medicine, Langenbeckstr. 2, 55131, Mainz, - - 2014
Objective: To determine the frequency and impact of gastrointestinal symptoms, and bowel and urinary incontinence, as this is currently unknown in adults with Pompe disease. Methods: Adult German Pompe patients and age- and gender-matched controls were asked about symptoms in the upper and lower intestinal tract as well as urinary ...
Fernandes Julien J Unité de Pathogenèse de Helicobacter, CNRS ERL3526, Institut - - 2014
Background: Gastric cancer (GC) represents a major health burden worldwide often diagnosed at an advanced-stage. Biomarkers for screening and prevention of GC are missing. Changes in peripheral blood mitochondrial DNA (mtDNA) have emerged as potential preventive/diagnosis biomarker for cancer risk. We aimed to determine whether peripheral leucocytes mtDNA levels are ...
Pareés Isabel I 1 Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, - - 2014
Functional movement disorders require attention to manifest yet patients report the abnormal movement to be out of their control. In this study we explore the phenomenon of sensory attenuation, a measure of the sense of agency for movement, in this group of patients by using a force matching task. Fourteen ...
Korkmaz Levent L aDepartment of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital bDepartment of Radiology, Akcaabat State Hospital, Trabzon, - - 2014
Detection of increased arterial stiffness could prevent patients from being mistakenly classified as being at a low or a moderate risk, when they actually are at a high risk. The main aim of present study was to investigate the relation between fragmented QRS (fQRS) on ECG and the cardio-ankle vascular ...
Matsushita Hiroshi H Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, - - 2014
Inappropriate innate immune responses have been suggested to contribute to the pathogenesis of primary sclerosing cholangitis (PSC). We evaluated the associations of expressions of toll-like receptor (TLR) 4, TLR9 and NOD-like receptor family pyrin domain containing 3 (NLRP3) in the biliary epithelial cells (BECs) with clinical features of PSC patients. ...
Schnakers Caroline C University Hospital of Liège, Liège, Belgium University of Liège, Liège, Belgium - - 2014
Background. Despite recent evidence suggesting that some severely brain-injured patients retain some capacity for top-down processing (covert cognition), the degree of sparing is unknown. Objective. Top-down attentional processing was assessed in patients in minimally conscious (MCS) and vegetative states (VS) using an active event-related potential (ERP) paradigm. Methods. A total ...
Mendoza-Pinto C C Systemic Autoimmune Diseases Research Unit, IMSS, Puebla, Mexico Department of Rheumatology and Immunology, Benemérita Universidad Autónoma de Puebla, - - 2014
Low bone mineral density (BMD) and vertebral fractures (VF) have been associated with atherosclerosis in the general population. We sought to investigate the relationship between BMD and VF and carotid atherosclerosis in women with systemic lupus erythematosus (SLE). We studied 122 women with SLE. All patients had BMD, carotid intima-media ...
Liu Yong Y Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China These authors contributed equally to this - - 2014
We determined a relatively safe contrast media volume-to-creatinine clearance (V/CrCl) cutoff value to avoid contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients (n = 111) with reduced ejection fraction (<40%). Improved prediction of CIN in these patients would be useful. Multivariate regression models were used to evaluate whether ...
Akyüz Aydın A Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey - - 2014
This study investigated whether there is a relationship between atrial fibrillation (AF), mean platelet volume (MPV), and apnea hypopnea index (AHI) in patients who have obstructive sleep apnea syndrome (OSAS). We enrolled patients who had OSAS with either AF or normal sinus rhythm (NSR). We divided 90 patients (aged 50-80 ...
Ahn J HyunBaek JH Department of Oral and Maxillofacial Surgery, Northampton General Hospital, Northampton, United - - 2014
Background The anterolateral thigh flap has gained popularity over the last few decades for the reconstruction of various surgical defects. The anatomy of the main perforating vessel of the anterolateral flap, the descending branch of the lateral circumflex femoral artery (dbLCFA), has been well described in the literature, however only one ...
Blight Andrew R AR Acorda Therapeutics, Ardsley, New - - 2014
Walking impairment is a clinical hallmark of multiple sclerosis (MS). Dalfampridine-ER, an extended-release formulation of dalfampridine (also known by its chemical name, 4-aminopyridine, and its international nonproprietary name, fampridine), was developed to maintain drug plasma levels within a narrow therapeutic window, and assessed for its ability to improve walking in ...
Dahlqvist J R JR Neuromuscular Research Unit, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, - - 2014
Patients with myotonic dystrophy type 1 (DM1) have an increased incidence of endocrine dysfunction. In this study, the temporal evolution of endocrine dysfunction in patients with DM1 was investigated. Endocrine function was assessed in 68 patients with DM1, in whom endocrine function had been followed, on average, for 8 years. The ...
Kosturakis Alyssa K AK Alyssa K. Kosturakis, Zijing He, Yan Li, Nina Shah, Sheeba K. Thomas, Haijun Zhang, Elisabeth G. Vichaya, Xin Shelley Wang, Charles S. Cleeland, and Patrick M. Dougherty, University of Texas MD Anderson Cancer Center, Houston, TX; Jessica A. Boyette-Davis, York College, York, PA; Gwen Wendelschafer-Crabb and William R. Kennedy, University of Minnesota School of Medicine; and Donald A. Simone, University of Minnesota School of Dentistry, Minneapolis, - - 2014
The goal in this study was to determine the incidence of subclinical neuropathy in treatment-naive patients with multiple myeloma (MM) with no history of peripheral neuropathy using quantitative sensory tests (QSTs) and its correlation with innervation density of the extremities using noninvasive laser reflectance confocal microscopy. QST results were collected ...
Tani N N Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, - - 2014
Systematic study of pemphigoid gestationis (PG) has not been performed due to rarity of PG. Clinical and immunological analyses for 25 new PG patients. In addition to clinical and histopathological assessments, we performed various immunofluorescence, immunoblotting and enzyme-linked immunosorbent assays (ELISAs). PG developed preferentially during second or third trimester of ...
Kaido T T Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, - - 2014
Severe sepsis is a life-threatening complication after liver transplantation (LT) that can be difficult to diagnose and appropriately treat after LT because of patients being treated with immunosuppressants. The present study examines perioperative changes in serum procalcitonin (PCT), a specific marker of systemic bacterial infection, and determines the value of ...
Hung Szu-Chun SC Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Buddhist Tzu Chi University, - - 2014
The introduction of erythropoiesis-stimulating agents (ESAs) markedly improved the lives of many anemic patients with chronic kidney disease (CKD). In Taiwan, the strategy of management of anemia in patients with CKD was different from many other parts of the world. In 1996, the National Health Insurance Administration of Taiwan applied ...
Takeuchi Naoyuki N 1Department of Physical Medicine and Rehabilitation, Tohoku University Graduates School of Medicine, Sendai, Japan 2Rehabilitation Support Center, Miyagi Prefectural Government, Natori, - - 2014
Sensorimotor rhythm (SMR) patterns in patients with lower limb amputations might be altered due to reorganization of the sensorimotor cortices. We evaluated the SMR of motor imagery (MI) in healthy subjects and patients with lower limb amputations. In addition, we investigated whether transcranial direct current stimulation (tDCS) could modulate SMR ...
El-Chammas Khalil I KI *Mercy Medical Center, Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition Des Moines, IA †Makassed Hospital, Department of Pediatrics, Division of Pediatric Pulmonology, Jerusalem, Israel ‡Boston University, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Boston, MA §Medical College of Wisconsin, Department of Pediatrics, Division of Pediatric Pulmonology, Milwaukee, WI ||Medical College of Wisconsin, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Milwaukee, - - 2014
Screening for cystic fibrosis (CF) is suggested in patients with rectal prolapse. Little is known about this association in the era of newborn screening (NBS) for CF. Our retrospective review showed that 3.6% of patients with rectal prolapse had CF, and 3.5% of CF patients had rectal prolapse. No demographic ...
Takaya Yoichi Y Department of Cardiology, National Cerebral and Cardiovascular Center, Suita, - - 2014
Since acute kidney injury (AKI) is not always related to mortality in patients with acute decompensated heart failure (ADHF), the aim of this study was to focus on onset time of AKI and its clinical importance. A total of 371 ADHF patients were included. The impact of AKI (≥0.3 mg/dl or ...
Ardissino Gianluigi G Center for HUS Control, Prevention and Management, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milan, Italy, - - 2014
Shigatoxin-associated hemolytic uremic syndrome (STEC-HUS) is a common thrombotic microangiopathy (TMA) in which central nervous system (CNS) involvement is responsible for the majority of deaths and for severe long-term sequelae. We have analyzed the role of hemoconcentration in disease severity. This was a retrospective review of the records and laboratory ...
Rolf Sascha S University of Leipzig - Heart Center, Department of Electrophysiology, Leipzig, Germany - - 2014
-Reduced electrogram amplitude has been shown to correlate with diseased myocardium. We describe a novel individualized approach for catheter ablation of atrial fibrillation (AF) based on low-voltage areas (LVAs) in the left atrium (LA). We sought to assess (a) the incidence of LVAs in patients undergoing AF catheter ablation, (b) ...
Sato Fumiya F Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-Ku, Nagoya, 466-8550, - - 2014
Left hepatic trisectionectomy is a challenging procedure. For an anatomically correct resection, it is necessary to have understanding of the right intersectional plane; however, little is known on this issue. The purpose of this study was to investigate the 3D anatomy of the right intersectional plane and to enable safe ...
Koca Bülent B Department of Paediatric Cardiology, Harran University Medical Faculty, Şanlıurfa, Turkey, - - 2014
Juvenile idiopathic arthritis (JIA) is a systemic chronic inflammatory disease. Cardiac involvement as pericarditis, myocarditis and valvular disease is common in JIA. This study aims to assess left ventricular (LV) diastolic functions with tissue Doppler imaging (TDI) and to compare it with conventional Doppler echocardiography (pulse wave Doppler (PWD)) techniques ...
Laukka Jeremy J JJ Department of Neuroscience, University of Toledo, Toledo, Ohio; Center of Molecular Medicine and Genetics, Wayne State University, Detroit, - - 2014
Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder of the central nervous system (CNS) caused by a wide variety of mutations affecting proteolipid protein 1 (PLP1). We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging. Twelve patients with different PLP1 point ...
Pellino Gianluca G Department of Medical, Surgical, Neurologic, Metabolic and Ageing Sciences, Second University of Naples, Naples, Italy. Electronic address: - - 2014
A higher rate of patients suffering from inflammatory bowel diseases (IBD) are reported to experience the symptom of fatigue compared with general population. Fatigue can impair quality of life of IBD patients by limiting their daily functioning. However, this problem is poorly understood and addressed. Our aim was to investigate ...
Gallego-Villar Lorena L Centro de Biología Molecular "Severo Ochoa", UAM-CSIC, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), IdiPAZ, Madrid, - - 2014
Propionic acidemia (PA), caused by a deficiency of the mitochondrial biotin dependent enzyme propionyl-CoA carboxylase (PCC) is one of the most frequent organic acidurias in humans. Most PA patients present in the neonatal period with metabolic acidosis and hyperammonemia, developing different neurological symptoms, movement disorders and cardiac complications. There is ...
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