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Sonoyama Takuhiro T Department of Medicine and Clinical ScienceKyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, - - 2014
We recently reported that stimulation with high-dose ACTH caused different responses in terms of aldosterone secretion in aldosterone-producing adenomas (APAs) and idiopathic hyperaldosteronism (IHA) in patients with primary aldosteronism (PA). However, the role of endogenous ACTH in aldosterone secretion in PA has not been systematically evaluated. In this study, we ...
Huang Maotao M Department of Gastroenterology and Endocrinology, The 452(nd) Hospital of PLA, Chengdu, China. Electronic address: - - 2014
Currently, there is no treatment for decompensated liver cirrhosis except for liver transplantation. The safety and effect on liver function of a transjugular intrahepatic portosystemic shunt (TIPS) with and without autologous bone marrow cell (BMC) infusion in patients with decompensated liver cirrhosis were determined. Ten patients who were diagnosed with ...
Signoretti Marianna M Digestive and Liver Disease Unit, S. Andrea Hospital, University "Sapienza," Rome, - - 2014
To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in chronic pancreatitis (CP), and analyze factors related with SIBO in CP. SIBO is to be considered a factor that worsens symptoms and nutritional status in patients with CP. However, the few studies evaluating the rate of SIBO in CP ...
Zhang Ni N Department of Hematology, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
The aim of the present study was to investigate the expression and effect of progranulin (PGRN) in patients with primary Sjögren's syndrome (pSS). In total, 26 newly diagnosed pSS patients and 26 healthy subjects were enrolled in this study. The serum levels of PGRN and the inflammatory factor, interleukin-6 (IL-6), ...
Stolpman David R DR *Department of Gastroenterology, Park Nicollet Clinic †Park Nicollet Institute, St Louis Park ‡Department of Internal Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, - - 2014
To achieve an excellent bowel preparation, it is routine to require a clear liquid diet on the day before the procedure. Unfortunately, this dietary modification may be poorly tolerated. We examine whether a change in precolonoscopy dietary restriction can lead to better patient tolerance without compromising examination quality. This is ...
Bagattini Brunella B Endocrinology SectionDepartment of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Cisanello, Pisa 56124, - - 2014
Levothyroxine (l-T4) is commonly employed to correct hormone deficiency in children with congenital hypothyroidism (CH) and in adult patients with iatrogenic hypothyroidism. To compare the daily weight-based dosage of the replacement therapy with l-T4 in athyreotic adult patients affected by CH and adult patients with thyroid nodular or cancer diseases ...
Zulueta-Santos Cristina C Department of Otorhinolaryngology, Clínica Universidad de Navarra, University Hospital and Medical School, University of Navarra , Pamplona, Navarra , - - 2014
Abstract Conclusion: The distribution of abnormal results is not uniform between different canals in each patient; the most frequent gain reduction is obtained for the posterior canal. Gain reduction reflects the disease duration and amount of hearing loss. To test the hypothesis that the vestibulo-ocular reflex (VOR) evoked after stimulation ...
Ornek Ahmet A Department of Internal Medicine I, Marienhospital Herne, Medical Center of Ruhr University Bochum, Herne, Germany (A.Ö., M.K., B.F.H., N.P., A.G.); Institute for Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Bergmannsheil, Ruhr University Bochum, Bochum, Germany (A.Ö.); and Department of Internal Medicine I, St Josef-Hospital, Medical Center of Ruhr University Bochum, Bochum, Germany (R.S., W.S., - - 2014
Familial Mediterranean fever (FMF) can be associated with splenomegaly. Prospective quantitative data are lacking. We performed a sonographic assessment of spleen size in patients with FMF and healthy control participants to assess its diagnostic value. Patients with FMF according to the criteria of Livneh et al (Arthritis Rheum 1997; 40:1879-1885) ...
Tufan Zeliha Kocak ZK Department of Infectious Diseases and Clinical Microbiology, Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Ankara, Turkey (Z.K.T.); and Departments of Radiology (H.Y., M.K., P.K.) and Infectious Diseases and Clinical Microbiology (C.B., G.C., C.A.H., S.K., A.P.D.), Ankara Training and Research Hospital, Ankara, Turkey. - - 2014
Crimean-Congo hemorrhagic fever (CCHF) has been endemic in Turkey since 2002. Some radiologic findings are considered common by clinicians and radiologists. In this regard, we aimed to assess the sonographic findings in patents with CCHF in a pilot study to obtain basic knowledge for planning further controlled studies. An observational ...
Su Li-Xin LX Department of Oral and Maxillofacial & Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China, - - 2014
Arteriovenous malformations (AVMs) involving the periorbital region are technically challenging clinical entities to manage. The purpose of the present study was to present our initial experience of ethanol embolization in a series of 16 patients with auricular AVMs and assess the outcomes of this treatment. Transcatheter arterial embolization and/or direct ...
Dohan Anthony A Department of Abdominal and Interventional Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 2 rue Ambroise Paré, 75010, Paris, France, - - 2014
To assess the role and effectiveness of percutaneous arterial embolization (TAE) in patients with hemodynamic instability due to hypovolemic shock secondary to ruptured splanchnic artery pseudoaneurysms (SAPA). Seventeen patients (11 men, 6 women; mean age, 53 years) with hemodynamic instability (systolic blood pressure <90 mmHg) due to hypovolemic shock secondary to ruptured ...
Lu Z-H ZH Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, 100029, Beijing, Chaoyang District, P.R. - - 2014
The aim of this study was to evaluate whether the levels of HbA1c could predict the outcome of ablation in patients with type 2 diabetes mellitus (T2DM) and paroxysmal atrial fibrillation (PAF). The study comprised 149 consecutive patients with T2DM and PAF who underwent their first circumferential pulmonary vein isolation. ...
Gutiérrez-Adrianzén O A OA Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, - - 2014
The pathophysiological mechanisms of arterial hypertension during hemodialysis (HD) in patients with end-stage renal disease (ESRD) are still poorly understood. The aim of this study is to investigate physiological, cardiovascular and neuroendocrine changes in patients with ESRD and its correlation with changes in blood pressure (BP) during the HD session. ...
Koseekriniramol Vasan V Department of Diagnostic and Therapeutic Radiology, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchatewi, Bangkok, 10400, - - 2014
To evaluate clinical and imaging factors for potential use in predicting appendix visualization on sonography (US) of adult patients with suspected appendicitis. All adult patients who underwent appendiceal US from January through June 2010 were included in this retrospective study. Clinicopathological records were reviewed for age, sex, weight, body mass ...
Patay Zoltan Z Department of Radiological Sciences, St. Jude Children's Research Hospital and Research Center, Memphis, TN, USA, - - 2014
Patients with L-2-hydroxyglutaric aciduria are at risk for developing cerebral neoplasms, particularly gliomas, as one of the optical isomers of the known oncometabolite, 2-hydroxyglutarate is produced in L-2-hydroxyglutaric aciduria. To illustrate the concept of sustained oncogenic potential in permanent exposure to L-2-hydroxyglutarate in brain tissue, we present the medical history ...
Sen Hanim H Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The - - 2014
Aims: Drug-eluting stents (DES) were first used on-label - in simple patients with low clinical risk and easily accessible lesions. Currently, DES are increasingly used off-label - in complex patients undergoing percutaneous coronary interventions (PCI) with historically higher event risk. Therefore, our aim was to investigate whether patients with off-label ...
Ishido Naoko N Osaka University Graduate School of Medicine, Department of Biomedical Informatics, Division of Health Science , 1-7, Yamadaoka , Suita, Japan, 565-0871 , +81-6-6879-2596 , +81-6-6879-2596 ; - - 2014
Background: Autoimmune thyroid diseases (AITDs) predominantly develop in females. One of two X chromosomes is randomly inactivated by methylation in each female cell, but it has been reported that skewed X chromosome inactivation (XCI) may be associated with the development of autoimmune diseases. To clarify the significance of skewed XCI ...
Eder Piotr P 1Department of Gastroenterology,Human Nutrition and Internal Diseases,Poznan University of Medical - - 2014
A case of agomelatine-induced hepatotoxicity is described in a 47-year female patient who has received the drug, 25 mg/day, for 4 months, for the treatment of depression. The patient was admitted to the Department of Gastroenterology because of fatigue and nausea, with concomitant elevation of alanine aminotransferase (ALT), 550 U/L, ...
Seifert Claudia C Section for Hematology and Oncology, Department of Pediatrics, Jena University Hospital, Kochstraße 2, 07740, Jena, - - 2014
Sinusoidal obstruction syndrome (SOS) is a life-threatening early complication after hematopoietic stem cell transplantation (HSCT), and until now, examinations about the influence of genetic risk factors are extremely rare. The purpose of this study was to identify an association between heparanase (HPSE) single nucleotide polymorphisms (SNPs) and SOS in children ...
Valimahamed-Mitha Sarah S Service de Pneumologie pédiatrique, Hôpital Jeanne de Flandre, CHRU de Lille, Paris, France, - - 2014
Lysinuric protein intolerance (LPI) is a rare multisystemic metabolic disease. The objective of the study was to describe presentation and course of lung involvement in a cohort of ten children. Retrospective review of patients followed at Necker-Enfants Malades University Hospital between 1980 and 2012 for a LPI. In patients with ...
De Backer Ole - - 2014
Some patients with Takotsubo cardiomyopathy (TTC) develop cardiogenic shock due to left ventricular outflow tract (LVOT) obstruction - there is, however, a paucity of data regarding this condition. Prevalence, associated factors and management implications of LVOT obstruction in TTC was explored, based on two-year data from two Belgian heart centres. ...
McNeil Brian K - - 2014
Among genitourinary malignancies, bladder cancer (BCa) ranks second in both prevalence and cause of death. Biomarkers of BCa for diagnosis, prognosis and disease surveillance could potentially help prevent progression, improve survival rates and reduce health care costs. Among several oncogenic signaling pathways implicated in BCa progression is that of hepatocyte ...
Jeganathan Niranjan N Division of Pulmonary and Critical Care Medicine, Rush University Medical Center and Rush Medical College, Chicago, Illinois. - - 2014
Several patient populations have been identified as high risk for extubation failure despite successful completion of a spontaneous breathing trial (SBT). Extubation failure and subsequent need for emergent re-intubation have been associated with increased morbidity and mortality. In this review, we discuss ways to optimize the value and performance of ...
Kim Won W Genitourinary Medical Oncology, UCSF Helen Diller Family Comprehensive Cancer Center - - 2014
Purpose: Patients previously treated with ketoconazole were excluded from phase III trials of abiraterone acetate due to potential overlapping mechanism of action. The purpose of this study was to determine the clinical utility of abiraterone and its impact on circulating androgens following ketoconazole. Experimental Design: Chemotherapy-naïve patients with progressive metastatic ...
Benezet-Mazuecos Juan J Department of Cardiology, Hospital Universitario Fundación Jiménez Díaz - IDC salud, Universidad Autónoma de Madrid, Avenida Reyes Católicos 2, Madrid 28040, Spain - - 2014
Monitoring capabilities of cardiac implantable electronic devices have revealed that a large proportion of patients present silent atrial fibrillation (AF) detected as atrial high rate episodes (AHREs). Atrial high rate episodes >5 min have been linked to increased risk of clinical stroke, but a high proportion of ischaemic brain lesions ...
Hammoud Ghassan M GM Ghassan M Hammoud, Jamal A Ibdah, Division of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO 65212, United - - 2014
Endoscopic ultrasound (EUS) has revolutionized the diagnostic and therapeutic approach to patients with gastrointestinal disorders. Its application in patients with liver disease and portal hypertension is increasing. Patients with chronic liver disease are at risk for development of portal hypertension sequale such as ascites, spontaneous bacterial peritonitis and gastroesophageal varices. ...
Shiotani Akiko A aDepartment of Internal Medicine, Division of Gastroenterology bDepartment of Clinical Pathology and Laboratory Medicine cDepartment of Comprehensive Medicine, Kawasaki Medical School, Okayama, - - 2014
PillCam patency capsule (PC) is a novel and radiofrequency identification tag-free device that remains intact in the gastrointestinal tract for 30-33 h after ingestion and then disintegrates. The aim of this study was to determine the clinical relevance of PC combined with abdominal ultrasonography as a reliable indicator of functional patency. ...
Jiang Ping P aThe Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health bDepartment of Cardiology, Beijing Tiantan Hospital, Capital Medical University cLaboratory of Electron Microscopy, Peking University First Hospital, Beijing, - - 2014
It is well known that the interaction between platelets (PLTs), endothelial cells, and leukocytes contributes to thrombosis in patients with acute coronary syndrome. The aim of this study was to investigate the significance of PLTs and eosinophils (EOS) in coronary arterial thrombi. PLT count, mean PLT volume, PLT mass, EOS ...
Rosas José J Department of Rheumatology, Marina Baixa Hospital, Villajoyosa, Alicante, Spain. - - 2014
The aim of this paper is to assess the usefulness of measuring serum levels of adalimumab (ADL) and anti-ADL antibodies in 57 patients with rheumatoid arthritis (RA) treated with ADL for at least 3 months in daily practice. All patients received concomitant disease-modifying anti-rheumatic drug (DMARD). Receiver-operator characteristics (ROC) analysis ...
Sivula M M Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, - - 2014
Matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinases-1 (TIMP-1) have recently been suggested to be involved in coagulation process. Our objectives were to observe systemic MMP-8 and TIMP-1 levels in patients with severe sepsis with or without disseminated intravascular coagulation (DIC) and to study their relationship with coagulation markers over ...
Saguner Ardan M AM Department of Cardiology, University Heart Center - - 2014
Background:The clinical role of atrial fibrillation/atrial flutter (AF-AFl) and variables predicting these arrhythmias are not well defined in patients with arrhythmogenic right ventricular dysplasia (ARVD). We hypothesized that transthoracic echocardiography (TTE) and 12-lead electrocardiography (ECG) would be helpful in predicting AF-AFl in these patients.Methods and Results:ECGs and TTEs of 90 patients diagnosed ...
Gordon Monica - - 2014
IntroductionExternal ventricular drainage (EVD)-related ventriculitis is one of the most severe complications associated with the use of EVDs. Establishing an early and certain diagnosis can be difficult in critically ill patients. We performed this prospective study to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) determination ...
Tapolyai Mihály M Fresenius Medical Care Hungary, Semmelweis University, Budapest, Hungary; Carolinas Campus, Edward Via Osteopathic College of Medicine, Spartanburg, - - 2014
The authors examined the relationship between thiazide-type diuretics and fluid spaces in a cohort of hypertensive patients in a retrospective study of 60 stable hypertensive patients without renal abnormalities who underwent whole-body bioimpedance analysis. Overhydration was greater in the diuretic group, but only to a nonsignificant degree (5.9 vs 2.9%; ...
Talib Ahmed Karim AK Department of Cardiology, Asahikawa Medical University; Department of Laboratory Medicine, Asahikawa Medical - - 2014
We reported impaired QT-rate dependence in early repolarization syndrome (ERS); however, contemporary data have shown peak incidence of sudden cardiac death (SCD) in ERS and Brugada syndrome (BrS) at mid-night and early morning. Taken together, we analyzed the nocturnal QT-rate dependence in both syndromes. A total of 172 subjects were ...
Jafarzadeh A A Neurology Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran, - - 2014
The regulatory T (Treg) cells play a major role in the control of the autoimmunity and inflammation, and IL-35 has been described as an immunosuppressive cytokine that is mainly produced by CD4(+) FOXP3(+) Treg cells. The aim of this study was to evaluate the serum levels of IL-35 and a ...
Berger Steve S Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland, - - 2014
The clinical tests currently used to assess spinal biomechanics preoperatively are unable to assess true mechanical spinal stiffness. They rely on spinal displacement without considering the force required to deform a patient's spine. We propose a preoperative method for noninvasively quantifying the three-dimensional patient-specific stiffness of the spines of adolescent ...
Tscholl Philippe M PM Department of Orthopedic Surgery, Orthopedic University Hospital Balgrist, University of Zurich, Zurich, Switzerland, - - 2014
Increased tibial tubercle trochlear groove distance (TT-TG) is frequently associated with trochlear dysplasia (TD). Since the trochlear groove appears more distally in patients with TD compared to controls, it is unknown whether TT-TG might be comparable and meaningful. Fifty patients with TD were retrospectively analysed and compared to 52 age- ...
Wang Zhong-Xia ZX Department of Graduate School, 301 Hospital, Beijing, China; Integrative Medical Centre, 302 Hospital, Beijing, - - 2014
Caroli's disease (CD) is a rare congenital disorder. The early diagnosis of the disease and differentiation of types I and II are of extreme importance to patient survival. This study was designed to review and discuss observations in 30 patients with CD and to clarify the clinical characteristics of the ...
Verrotti Alberto A Department of Pediatrics, University of Perugia, Perugia, Italy, - - 2014
Prader-Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader-Willi ...
Ishii Rui R Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, - - 2014
Elevated eosinophil count was shown to be associated with the development of cholesterol embolization syndrome, a potentially life-threatening condition, after catheter-based procedures. We investigated the association between stages of chronic kidney disease (CKD) and the absolute eosinophil count (AEC) among cardiac patients. CKD stages were determined solely on the estimated ...
Lim Jun Uk JU Department of Gastroenterology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, - - 2014
Although current guideline recommends selective use of pre-endoscopic prokinetics to increase diagnostic yield in upper gastrointestinal bleeding (UGIB) patients, no data to guide the use of these drugs are available. We aimed to investigate predictive factors for endoscopic visibility and develop simple and useful strategies for pre-endoscopic prokinetics use in ...
Kang Yun-Seong YS Department of Internal Medicine, College of Medicine, Dongguk University Ilsan Hospital, Goyang, 410-773, Republic of - - 2014
CT-P13 is the first biosimilar monoclonal antibody to infliximab. However, the antibody was tested only in rheumatoid arthritis and ankylosing spondylitis, which demonstrated equivalence to the originator in efficacy, safety, and pharmacokinetic profile. Extrapolation of its efficacy and safety to other pathologies is tenuous. Interchangeability with its originator is another ...
Zhang Ruijie R Department of Medical Imaging, Jinan Military General Hospital, No.25, Shifan Road, Jinan, Shandong Province, China, - - 2014
The purpose of this investigation was to examine the association between cognition disorders and microstructural white matter (WM) changes in maintenance hemodialysis end-stage renal disease (ESRD) patients. Twenty-six maintenance hemodialysis ESRD patients and 28 healthy controls underwent diffusion tensor imaging (DTI), Mini Mental State Examination (MMSE), Trial Marking Test-A&B (TMT-A&B), ...
Yoshida Yuko Y Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, - - 2014
Although preoperative biliary drainage in jaundiced patients is controversial, external biliary drainage (EBD) is beneficial for infection control in patients with biliary cancers. When EBD is performed, additional bile replacement (BR) has the benefit of improving impaired intestinal barrier function, but the detailed mechanism remains unknown. We examined the effect ...
Vearrier David D Department of Emergency Medicine, Drexel University College of Medicine, 245 N. 15th St, Mail Stop 1011, Philadelphia, PA, 19102, USA, - - 2014
Phenol is a caustic that may cause cutaneous or gastrointestinal burns depending on the route of exposure. Significant absorption may result in systemic toxicity. We present a case of topical phenol exposure resulting in cutaneous burns and systemic phenol toxicity. A 9-year-old girl was exposed to Creolin®, a general-purpose disinfectant ...
Manfredi A A Rheumatology Unit, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41121, Modena, Italy, - - 2014
Inflammatory myopathies (IM) are a group of muscle diseases occurring both in children and adults. Nailfold videocapillaroscopy (NVC) alterations are described in IM, but available data are discordant, including differences between polymyositis (PM) and dermatomyositis (DM). The aim of this study was to describe the capillaroscopic differences between PM and ...
Shoda Katsutoshi K Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramach Hirokoji Kajiicho, Kamigyo-ku, Kyoto, 602-8566, - - 2014
We used real-time quantitative polymerase chain reaction (rqPCR) to detect human epidermal growth factor receptor 2 (HER2) amplification in the circulating cell-free DNA (cfDNA) of patients with gastric cancer (GC), which shows the spatial and temporal intrinsic heterogeneity of HER2 expression/copy number during progression, for liquid biopsy and treatment monitoring. ...
Wagenmakers Maem M Department of Medicine, Division of Endocrinology, Radboud University Medical Centre, Geert Grooteplein 8, 6500 HB, Nijmegen, the - - 2014
Centripetal obesity is associated with systemic low-grade inflammation and an increased cardiovascular risk. Patients in long-term remission of Cushing's syndrome (CS) report persisting abdominal fat accumulation. However, this has previously not been adequately objectified. Therefore we investigated the adipose tissue distribution and adipocytokine profiles of patients in long-term remission of ...
Reibis Rona R Department of Cardiology, Klinik am See, Rüdersdorf, - - 2014
Abstract Background. We aimed to describe the contemporary management of patients with systolic chronic heart failure (CHF) during a cardiac rehabilitation (CR) stay and present outcomes with focus on lipids, blood pressure, exercise capacity, and clinical events. Methods. Comparison of 3,199 patients with moderately or severely impaired left ventricular ejection ...
Rak Michael M Max-Plank-Institute of Psychiatry, Munich, - - 2014
Nightmares are a frequent symptom in narcolepsy. Lucid dreaming, i.e., the phenomenon of becoming aware of the dreaming state during dreaming, has been demonstrated to be of therapeutic value for recurrent nightmares. Data on lucid dreaming in narcolepsy patients, however, is sparse. The aim of this study was to evaluate ...
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