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Sonoyama Takuhiro T Department of Medicine and Clinical ScienceKyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, - - 2014
We recently reported that stimulation with high-dose ACTH caused different responses in terms of aldosterone secretion in aldosterone-producing adenomas (APAs) and idiopathic hyperaldosteronism (IHA) in patients with primary aldosteronism (PA). However, the role of endogenous ACTH in aldosterone secretion in PA has not been systematically evaluated. In this study, we ...
Huang Maotao M Department of Gastroenterology and Endocrinology, The 452(nd) Hospital of PLA, Chengdu, China. Electronic address: - - 2014
Currently, there is no treatment for decompensated liver cirrhosis except for liver transplantation. The safety and effect on liver function of a transjugular intrahepatic portosystemic shunt (TIPS) with and without autologous bone marrow cell (BMC) infusion in patients with decompensated liver cirrhosis were determined. Ten patients who were diagnosed with ...
Signoretti Marianna M Digestive and Liver Disease Unit, S. Andrea Hospital, University "Sapienza," Rome, - - 2014
To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in chronic pancreatitis (CP), and analyze factors related with SIBO in CP. SIBO is to be considered a factor that worsens symptoms and nutritional status in patients with CP. However, the few studies evaluating the rate of SIBO in CP ...
Zhang Ni N Department of Hematology, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
The aim of the present study was to investigate the expression and effect of progranulin (PGRN) in patients with primary Sjögren's syndrome (pSS). In total, 26 newly diagnosed pSS patients and 26 healthy subjects were enrolled in this study. The serum levels of PGRN and the inflammatory factor, interleukin-6 (IL-6), ...
Stolpman David R DR *Department of Gastroenterology, Park Nicollet Clinic †Park Nicollet Institute, St Louis Park ‡Department of Internal Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, - - 2014
To achieve an excellent bowel preparation, it is routine to require a clear liquid diet on the day before the procedure. Unfortunately, this dietary modification may be poorly tolerated. We examine whether a change in precolonoscopy dietary restriction can lead to better patient tolerance without compromising examination quality. This is ...
Bagattini Brunella B Endocrinology SectionDepartment of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Cisanello, Pisa 56124, - - 2014
Levothyroxine (l-T4) is commonly employed to correct hormone deficiency in children with congenital hypothyroidism (CH) and in adult patients with iatrogenic hypothyroidism. To compare the daily weight-based dosage of the replacement therapy with l-T4 in athyreotic adult patients affected by CH and adult patients with thyroid nodular or cancer diseases ...
Zulueta-Santos Cristina C Department of Otorhinolaryngology, Clínica Universidad de Navarra, University Hospital and Medical School, University of Navarra , Pamplona, Navarra , - - 2014
Abstract Conclusion: The distribution of abnormal results is not uniform between different canals in each patient; the most frequent gain reduction is obtained for the posterior canal. Gain reduction reflects the disease duration and amount of hearing loss. To test the hypothesis that the vestibulo-ocular reflex (VOR) evoked after stimulation ...
Jafarzadeh A A Neurology Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran, - - 2014
The regulatory T (Treg) cells play a major role in the control of the autoimmunity and inflammation, and IL-35 has been described as an immunosuppressive cytokine that is mainly produced by CD4(+) FOXP3(+) Treg cells. The aim of this study was to evaluate the serum levels of IL-35 and a ...
Berger Steve S Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland, - - 2014
The clinical tests currently used to assess spinal biomechanics preoperatively are unable to assess true mechanical spinal stiffness. They rely on spinal displacement without considering the force required to deform a patient's spine. We propose a preoperative method for noninvasively quantifying the three-dimensional patient-specific stiffness of the spines of adolescent ...
Tscholl Philippe M PM Department of Orthopedic Surgery, Orthopedic University Hospital Balgrist, University of Zurich, Zurich, Switzerland, - - 2014
Increased tibial tubercle trochlear groove distance (TT-TG) is frequently associated with trochlear dysplasia (TD). Since the trochlear groove appears more distally in patients with TD compared to controls, it is unknown whether TT-TG might be comparable and meaningful. Fifty patients with TD were retrospectively analysed and compared to 52 age- ...
Verrotti Alberto A Department of Pediatrics, University of Perugia, Perugia, Italy, - - 2014
Prader-Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader-Willi ...
Ishii Rui R Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, - - 2014
Elevated eosinophil count was shown to be associated with the development of cholesterol embolization syndrome, a potentially life-threatening condition, after catheter-based procedures. We investigated the association between stages of chronic kidney disease (CKD) and the absolute eosinophil count (AEC) among cardiac patients. CKD stages were determined solely on the estimated ...
Lim Jun Uk JU Department of Gastroenterology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, - - 2014
Although current guideline recommends selective use of pre-endoscopic prokinetics to increase diagnostic yield in upper gastrointestinal bleeding (UGIB) patients, no data to guide the use of these drugs are available. We aimed to investigate predictive factors for endoscopic visibility and develop simple and useful strategies for pre-endoscopic prokinetics use in ...
Kang Yun-Seong YS Department of Internal Medicine, College of Medicine, Dongguk University Ilsan Hospital, Goyang, 410-773, Republic of - - 2014
CT-P13 is the first biosimilar monoclonal antibody to infliximab. However, the antibody was tested only in rheumatoid arthritis and ankylosing spondylitis, which demonstrated equivalence to the originator in efficacy, safety, and pharmacokinetic profile. Extrapolation of its efficacy and safety to other pathologies is tenuous. Interchangeability with its originator is another ...
Zhang Ruijie R Department of Medical Imaging, Jinan Military General Hospital, No.25, Shifan Road, Jinan, Shandong Province, China, - - 2014
The purpose of this investigation was to examine the association between cognition disorders and microstructural white matter (WM) changes in maintenance hemodialysis end-stage renal disease (ESRD) patients. Twenty-six maintenance hemodialysis ESRD patients and 28 healthy controls underwent diffusion tensor imaging (DTI), Mini Mental State Examination (MMSE), Trial Marking Test-A&B (TMT-A&B), ...
Yoshida Yuko Y Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, - - 2014
Although preoperative biliary drainage in jaundiced patients is controversial, external biliary drainage (EBD) is beneficial for infection control in patients with biliary cancers. When EBD is performed, additional bile replacement (BR) has the benefit of improving impaired intestinal barrier function, but the detailed mechanism remains unknown. We examined the effect ...
Vearrier David D Department of Emergency Medicine, Drexel University College of Medicine, 245 N. 15th St, Mail Stop 1011, Philadelphia, PA, 19102, USA, - - 2014
Phenol is a caustic that may cause cutaneous or gastrointestinal burns depending on the route of exposure. Significant absorption may result in systemic toxicity. We present a case of topical phenol exposure resulting in cutaneous burns and systemic phenol toxicity. A 9-year-old girl was exposed to Creolin®, a general-purpose disinfectant ...
Manfredi A A Rheumatology Unit, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41121, Modena, Italy, - - 2014
Inflammatory myopathies (IM) are a group of muscle diseases occurring both in children and adults. Nailfold videocapillaroscopy (NVC) alterations are described in IM, but available data are discordant, including differences between polymyositis (PM) and dermatomyositis (DM). The aim of this study was to describe the capillaroscopic differences between PM and ...
Boltin Doron - - 2014
BackgroundRifaximin is a minimally absorbed antibiotic with high luminal activity, used to treat various gastrointestinal diseases. Although rifaximin has been proposed as first line treatment for small intestinal bacterial overgrowth (SIBO), few data are available regarding its efficacy in non-IBS subjects. We aimed to assess the ability of rifaximin to ...
Shoda Katsutoshi K Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramach Hirokoji Kajiicho, Kamigyo-ku, Kyoto, 602-8566, - - 2014
We used real-time quantitative polymerase chain reaction (rqPCR) to detect human epidermal growth factor receptor 2 (HER2) amplification in the circulating cell-free DNA (cfDNA) of patients with gastric cancer (GC), which shows the spatial and temporal intrinsic heterogeneity of HER2 expression/copy number during progression, for liquid biopsy and treatment monitoring. ...
Wagenmakers Maem M Department of Medicine, Division of Endocrinology, Radboud University Medical Centre, Geert Grooteplein 8, 6500 HB, Nijmegen, the - - 2014
Centripetal obesity is associated with systemic low-grade inflammation and an increased cardiovascular risk. Patients in long-term remission of Cushing's syndrome (CS) report persisting abdominal fat accumulation. However, this has previously not been adequately objectified. Therefore we investigated the adipose tissue distribution and adipocytokine profiles of patients in long-term remission of ...
Reibis Rona R Department of Cardiology, Klinik am See, Rüdersdorf, - - 2014
Abstract Background. We aimed to describe the contemporary management of patients with systolic chronic heart failure (CHF) during a cardiac rehabilitation (CR) stay and present outcomes with focus on lipids, blood pressure, exercise capacity, and clinical events. Methods. Comparison of 3,199 patients with moderately or severely impaired left ventricular ejection ...
Rak Michael M Max-Plank-Institute of Psychiatry, Munich, - - 2014
Nightmares are a frequent symptom in narcolepsy. Lucid dreaming, i.e., the phenomenon of becoming aware of the dreaming state during dreaming, has been demonstrated to be of therapeutic value for recurrent nightmares. Data on lucid dreaming in narcolepsy patients, however, is sparse. The aim of this study was to evaluate ...
Thunström Erik E Department of Molecular and Clinical Medicine, Institution of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2014
Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD). Enhanced vascular inflammation is implicated as a pathophysiologic mechanism but obesity is confounding. We aimed to address the association of OSA with inflammatory biomarkers in a nonobese cohort of revascularized patients with CAD and preserved left ventricular ...
Truin W W Department of Surgery, Máxima Medical Centre, Veldhoven, The Netherlands, - - 2014
The aim of this study was to compare the frequency of breast-conserving surgery (BCS) between early-stage invasive ductal (IDC) and invasive lobular breast cancer (ILC). Women with primary non-metastatic pT1 and pT2 IDC or ILC diagnosed between 1990 and 2010 were selected from the NCR. All patients underwent BCS or ...
Matsuba Yumiko Y Hals-, Nasen-, Ohrenklinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, - - 2014
To evaluate the clinical course of orbital complication using a standardised diagnostic pathway. Seventy-three patients with orbital complications underwent a multimodal diagnostic pathway comprising ENT examination, leucocytes/CRP, CT-/MRI-scanning and disease-related data. Twenty-nine patients suffered from rhinosinusitis, 28 from mucoceles, 13 patients from neoplasms and three patients from rheumatic disorders. Clinical ...
Akudugu John J Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa, - - 2014
To assay for uPA and PAI-1 in prostate tissue from 40 patients with prostatic disease and to examine the robustness of the correlation of the uPA/PAI-1 ratio with benign prostatic hyperplasia (BPH) and prostate cancer (PCa), previously identified in a different cohort of 62 patients. uPA and PAI-1 were extracted ...
Raouf Alaa A Department of Neurosurgery, Faculty of Medicine, Alexandria University, Champillion St., Elazaritta, Alexandria, - - 2014
Hydrocephalus is a very common disease in developing countries. Congenital aqueductal obstruction and post-inflammatory hydrocephalus come on the top of the list of causes of hydrocephalus. Till the recent introduction of cranial endoscopy and despite their frequent complications, shunts were considered as the mainstream treatment for this disease. Endoscopic third ...
Tremolaterra Fabrizio - - 2014
Fibromyalgia Syndrome (FMS) is a frequent comorbidity in Irritable Bowel Syndrome (IBS) patients with a higher functional bowel disorder severity index (FBDSI). We tested the possibility that mild to severe IBS patients without FMS would have a graduated visceral and somatic perception, and the presence of FMS would further enhance ...
Aghaebrahim Amin A Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, - - 2014
Previous studies have suggested that patients with wake-up stroke (WUS) may have superior outcomes compared with patients with a witnessed late time of onset after revascularization. We sought to test this hypothesis in patients with anterior circulation large vessel occlusion stroke (ACLVOS) treated with endovascular therapy beyond 8 h from time ...
Sato Eiichi E Department of Pathology, Dokkyo Medical University, Koshigaya - - 2014
The efficacy of tolvaptan for treating heart failure has already been shown. Adequate data relating to the effect of tolvaptan on the correlation of water balance in renal disease are not available. A retrospective study was conducted on the efficacy and adverse reactions of tolvaptan for treating nephrotic syndrome.The subjects ...
Takada Jun J Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan, - - 2014
Carbon dioxide (CO2) insufflation is effective for gastric endoscopic submucosal dissection (ESD). However, its safety is unknown in patients with pulmonary dysfunction. This study aimed to investigate the safety of CO2 insufflation during gastric ESD in patients with pulmonary dysfunction under conscious sedation. We analyzed 322 consecutive patients undergoing ESD ...
Fawzi Amani A AA Department of - - 2014
Our objective was to present clinicopathologic evidence of anterior visual pathway involvement in patients with amyotrophic lateral sclerosis (ALS) secondary to a C9orf72 mutation. Two related patients from an extended pedigree with ALS and GGGGCC hexanucleotide repeat expansion in the C9orf72 gene (C9-ALS) underwent neuro-ophthalmologic examination. Following death and tissue ...
Lupoli Ga G Department of Clinical Medicine and Surgery, University "Federico II", Via Pansini 5, 80131, Naples, - - 2014
Context: Thyroglobulin antibodies (TgAbs) are surrogate markers of disease recurrence or persistence in differentiated thyroid cancer (DTC). However the prognostic significance of TgAb heterogeneity in DTC has not been investigated. Objective: To evaluate the relationship between TgAb epitope specificities and clinical outcomes in DTC patients. Design: We studied 61 TgAb-positive ...
Siddique Iqbal I Department of Medicine, Faculty of Medicine, Kuwait University , Safat , - - 2014
Abstract Objective. Ulcerative colitis (UC) is generally considered a disease of the Caucasian populations in developed countries, but its incidence is increasing rapidly in many developing countries, including the Middle East. The objective of this study was to determine the clinical epidemiology of UC in Arabs. Material and methods. This ...
Hansen C K CK Department of Neurology, Bispebjerg University Hospital, Copenhagen, - - 2014
The frequency of acute large vessel occlusions in relation to clinical severity has not yet been established in a comprehensive, consecutive and unselected cohort of patients with hyper-acute cerebral ischemia. The aim of this study was to establish the frequency of acute large vessel occlusions and describe the relations to ...
Kuittinen Pekka - - 2014
Lumbar spinal stenosis (LSS) is the common term used to describe patients with symptoms related to the anatomical reduction of the lumbar spinal canal size. However, some subjects may have a markedly narrowed canal without any symptoms. This raises the question of what is the actual role of central canal ...
Campello E - - 2014
The role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in overweight and obese patients with and without metabolic syndrome is still a matter of debate. In a case-control study, the presence of hypercoagulability was evaluated in overweight and obese patients by measuring MP, thrombin generation (TG) ...
Pool Joan J Joan Pool, RN, MSE, BSN, CCRN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Margaret Dercher, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Belinda Hanson, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Linda Heiman, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Yan Li, MA Biostatistician, Saint Luke's Hospital of Kansas City, Missouri. Kim Schraeder, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Mary Pat Schultz, APRN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Shawna Ziglinski, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Marci Ebberts, RN, BSN, CCRN Clinical Education Specialist, Saint Luke's Hospital of Kansas City, - - 2014
Maintaining patient comfort and avoiding complications after coronary angiography are important both to the patient and the nurse. Strict bed rest with the head of bed (HOB) completely flat is standard care for postprocedure positioning to decrease pressure on the femoral artery. This position is not thought to be the ...
Park Hee Kyung HK Department of Neurology, Inje University Ilsan Paik Hospital, Goyang, - - 2014
Background & Objective: Early-onset Alzheimer's disease (EOAD, onset age <65 years) may differ from late-onset Alzheimer's disease (LOAD) in terms of cognitive profiles and neuropsychiatric symptoms. There have been few studies for Korean EOAD patients using well-structured databases. Previous studies focusing on cognitive profiles between the two groups had a ...
Gonzalez-Duarte Alejandra - - 2014
Background: Cryptococcal meningitis (CM) is a rare condition in non-HIV patients. The clinical manifestations in patients with systemic lupus erythematosus (SLE) are often confused with immunological activity, resulting in delayed diagnosis. Aims: We describe the natural history and outcome of eight HIV-negative patients with SLE and confirmed CM. Results: Mean ...
Savale Laurent L Université Paris-Sud, Faculté de Médecine, Le Kremlin Bicêtre, France AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, Hôpital de Bicêtre, Le Kremlin Bicêtre, France UMR_S 999, INSERM, Laboratoire d'Excellence (LabEx) en Recherche sur le Médicament et l'Innovation Thérapeutique (LERMIT), Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France - - 2014
Isolated cases of pulmonary arterial hypertension (PAH) in patients treated with interferon (IFN) α or β have been reported in the literature. The aim of this study was to describe all consecutive cases of PAH patients with a history of IFN exposure identified in the French reference centre for severe ...
Kemna Michael J MJ Clinical and Experimental Immunology and Cardiovascular Research Institute Maastricht - - 2014
The value of measuring ANCA during follow-up to predict a relapse is controversial. On the basis of recently obtained pathophysiologic insights, we postulated that measuring ANCA is useful in patients with renal involvement but is less valuable in patients with nonrenal disease. One hundred sixty-six consecutive patients with ANCA-associated vasculitis, ...
Diener Hans-Christoph HC Department of Neurology and Headache Center, University Hospital Essen, Germany - - 2014
Numerous studies have described a relationship between migraine and stroke, and there is emerging evidence that migraine is also associated with cardiovascular disease. The combination of migraine and both cerebrovascular and cardiovascular disease has implications for therapy. We conducted a review of the modifications in medical therapy in patients with ...
Purrucker Jan C JC Department of Neurology, Heidelberg University Hospital, Heidelberg, - - 2014
Background: In patients presenting with acute vertigo or dizziness, identifying the posterior fossa stroke as the underlying cause can be a major challenge. We therefore evaluated the serum biomarkers for the differential diagnosis of nonvascular vertigo and posterior circulation stroke. Methods: Of a total of 80 patients, 31 patients had ...
Risch Olivier - - 2014
PurposeBleeding is the most common and most serious complication of anticoagulant (AC) and antiplatelet agents (APA) which are increasingly used in every day practice. The aim of this study was to enlist and analyze the most severe bleeding events revealed during computed tomography scanner (CT scan) examinations over a 1-year ...
Florian Anca A Department of Cardiology and Angiology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, - - 2014
Cardiovascular magnetic resonance (CMR) has become a valuable diagnostic tool for non-invasive diagnosis of acute myocarditis. However, since CMR studies are time- and cost-intensive and its diagnostic accuracy still not perfect, additional parameters are warranted to preselect and identify those individuals in whom a CMR study is likely to add ...
Shah Nimish N Department of Gastroenterology, Jagjivan Ram Hospital, Maratha Mandir Marg, Mumbai, 400 008, India, - - 2014
Constipation may be primary or secondary. Pathophysiologic subtypes of primary constipation are dyssynergic defecation (DD), slow (STC), and normal transit constipation (NTC). Clinical subtypes are functional constipation (FC) and constipation predominant IBS (C-IBS). The objectives of this paper are to study the clinical profile, categorize and compare various subtypes of ...
Moufarrej Mira Noura MN Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA, - - 2014
To better understand the factors that affect low disease activity (DAS28 ≤ 3.2, LDA) in rheumatoid arthritis (RA) and barriers within the UAE, demographic/treatment data and DAS28 scores were collected through chart reviews of 182 consecutive RA patients seen at a private clinic in Dubai over a 2-month period. Patients were separated ...
Franeková J J Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. - - 2014
C-reactive protein (CRP) is a marker of arterial inflammation while lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is related to plaque instability. The aim of this study was to evaluate the correlation between the risk of unstable plaque presenting as acute coronary syndrome (ACS) and Lp-PLA(2), and to assess the influence of statins ...
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