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Sonoyama Takuhiro T Department of Medicine and Clinical ScienceKyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, - - 2014
We recently reported that stimulation with high-dose ACTH caused different responses in terms of aldosterone secretion in aldosterone-producing adenomas (APAs) and idiopathic hyperaldosteronism (IHA) in patients with primary aldosteronism (PA). However, the role of endogenous ACTH in aldosterone secretion in PA has not been systematically evaluated. In this study, we ...
Nicholson Andrew G AG Royal Brompton and Harefield NHS Foundation Trust, - - 2014
This presentation reviews the histopathology of the IIPs since the 2002 ATS/ERS classification of IIPs in the light of the 2013 update. The seven histological patterns proposed in 2002 remain, with diagnostic criteria refined but overall unchanged. A multidisciplinary approach is now established as best practice. NSIP is now recognised as ...
Ma Hui-Ping HP Department of Respiratory Medicine, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. - - 2014
Previous studies have revealed the role of matrix metalloproteinase 9 (MMP9) in asthma and chronic obstructive pulmonary disease (COPD). However, its role in airway inflammation in cough variant asthma (CVA) remains unknown. In the present study, variations in the levels of MMP9 and interleukin (IL)-5 in the induced sputum of ...
Long Yan-Yan YY Department of Medical Oncology, Chinese PLA General Hospital, Beijing 100853, P.R. China ; Medical School of Nankai University, Tianjin 300071, P.R. - - 2014
NY-ESO-1 has been identified as one of the most immunogenic antigens; thus, is a highly attractive target for cancer immunotherapy. The present study analyzed the expression of serum antibodies (Abs) against NY-ESO-1 in patients with advanced colorectal cancer (CRC), with the aim of guiding the treatment of NY-ESO-1-based specific-immunotherapy for ...
Bártová Petra P Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic. Electronic address: - - 2014
Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and (123)I-FP-CIT ([(123)I]ioflupane, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123)I]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of ...
Wen Xue X Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. - - 2014
Signet ring cell carcinoma (SRC) of the ampulla of Vater is extremely rare and the histogenesis remains unknown. In the present study, to investigate the immunohistochemical phenotypes, discuss the histological origin and evaluate the correlation between the immunohistochemical phenotypes and survival of ampullary SRC patients, a retrospective review was conducted. ...
Han Michelle S MS Department of Surgery, University of Rochester Medical Center, University of Rochester, 601 Elmwood Avenue, Box SURG, Rochester, NY 14642, - - 2014
The development and advancement of ambulatory esophageal pH monitoring has provided a key tool with which pathologic esophageal acid exposure can be objectively measured; although not perfect, it provides the clinician with arguably the most important piece of information in the diagnosis and management of patients with gastroesophageal reflux disease. ...
Lin Tess E TE Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina (UNC) at Chapel Hill, CB#7355, 301 Pharmacy Lane, Chapel Hill, NC 27599-7355, - - 2014
Hyponatremia is a known complication in patients with heart failure (HF). HF patients with severe congestion, hyponatremia, and renal insufficiency are difficult to manage and may have worse outcomes. A main cause of hyponatremia is inappropriately elevated level of plasma arginine vasopressin (AVP), which causes water retention at the collecting ...
Kim Chang-Hee CH *Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea; and †Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
To characterize the clinical features of patients who simultaneously developed ipsilateral sudden sensorineural hearing loss (SSNHL) and positional vertigo showing geotropic direction-changing positional nystagmus (DCPN) on a supine head-roll test, and to address the possible pathophysiology of the disease. Retrospective case series review. We conducted a retrospective case series study ...
Ribeiro Sle S Department of Medical Clinic; Faculty of Medicine, Universidade Federal do Amazonas, Manaus, Brazil - - 2014
β2 glycoprotein I (β2GPI) is a phospholipid binding protein that plays an important role in endothelial stability, blood coagulation, clearance of apoptotic debris and other physiologic processes. Anti-β2GPI antibodies occur in normal individuals and transiently during the course of infections, but are also associated with thrombotic events in autoimmune disease: ...
Dall'Ara F F Department of Clinical and Experimental Science, University of Brescia, Italy Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Italy - - 2014
To assess the prevalence of disease- and therapy-related complications and of the organ damage after a follow-up of 15 years or more in patients with primary antiphospholipid syndrome (PAPS). Medical records of patients prospectively followed in our centre for at least 15 years were retrospectively reviewed. Thirty-five Caucasian patients (33 ...
Han Xiang Y XY From the Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston; - - 2014
To differentiate the leprosy agents Mycobacterium leprae and Mycobacterium lepromatosis and correlate them with geographic distribution and clinicopathologic features. Species-specific polymerase chain reactions were used to detect each bacillus in archived skin biopsy specimens from patients with leprosy from Brazil (n = 52), Malaysia (n = 31), Myanmar (n = ...
Rajaei Mohammad H MH Department of Surgery, University of Wisconsin, Madison, - - 2014
Intraoperative parathyroid hormone (ioPTH) monitoring during focused parathyroidectomy for primary hyperparathyroidism (PHPT) is used commonly, but some argue that ioPTH adds little if a normal ipsilateral parathyroid gland (IPG) is visualized. This hypothesis was tested for validity. The prospective databases of consecutive patients with PHPT undergoing initial parathyroidectomy with ioPTH ...
Connelly Tara M TM Department of Surgery, Division of Colon & Rectal Surgery, The Pennsylvania State University, Hershey, - - 2014
Clinical studies have suggested that patients with inflammatory bowel disease (IBD) are at greater risk for developing Clostridium difficile infection (CDI). The purpose of this study was to identify single-nucleotide polymorphisms (SNPs) associated with CDI among IBD patients. This retrospective cohort study used our biobank to compare patients with IBD ...
Onders Raymond P RP University Hospitals Case Medical Center, Cleveland, OH. Electronic address: - - 2014
Diaphragm dysfunction (DD) can cause sleep abnormalities, dyspnea, atelectasis, and respiratory failure. Historical treatments, including positive pressure ventilation or diaphragm plication, may alleviate symptoms but do not restore physiologic diaphragm function. Diaphragm pacing (DP) is approved for spinal cord-injured patients and in amyotrophic lateral sclerosis. We report a series of ...
Velasco-Rodríguez Diego D From the Laboratorio Central de la Comunidad de Madrid, Madrid, Spain, and - - 2014
To analyze the differences not only in classic hematologic parameters but also in RBC subpopulations among δβ-thalassemia trait (δβ-TT), β-thalassemia trait (β-TT), and iron deficiency anemia (IDA) and to evaluate the role of fetal hemoglobin (HbF) in elevated RBC distribution width (RDW). Samples from 553 patients with microcytosis (74 δβ-TT, ...
Birsen Onur O Department of Endocrine Surgery, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, - - 2014
Although adrenal incidentalomas (AI) are detected in ≤5% of patients undergoing chest and abdominal computed tomography (CT), their management is challenging. The current guidelines include recommendations from the National Institutes of Health, the American Association of Endocrine Surgeons (AAES), and the American Association for Cancer Education (AACE). The aim of ...
Park Young Min YM Department of Otorhinolaryngology, Pundang Jesaeng Hospital, Deajin Medical Center, Seongnam, Gyeonggi, - - 2014
We investigated extrathyroidal extension (ETE) through frozen biopsy for intraoperative decision making in patients with papillary thyroid cancer (PTC). During the period of the study an operation was performed in 268 patients with PTC and ETE was evaluated using intraoperative frozen biopsies of thyroid tissue. Extrathyroidal extension was confirmed in ...
Paudel Klara K Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, - - 2014
Bioimpedance spectroscopy (BIS), ultrasound of lungs (lung ultrasound comets: LUC) and serum biomarkers (N-Terminal pro-brain natriuretic peptide, NT-proBNP) have been used to assist clinicians to determine hydration status in dialysis patients. But how do they compare? We performed simultaneous measurements of BIS, LUC and NT-proBNP in 27 peritoneal dialysis patients ...
Matsuda Shunichi S Department of Neurology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, - - 2014
The aim of paper was to investigate abnormalities in visual scanning using an eye-tracking device with patients with spinocerebellar ataxia type 6 (SCA6) and SCA31, pure cerebellar types of spinocerebellar degeneration. Nineteen SCA patients (12 patients with SCA6 and 7 patients with SCA31) and 19 normal subjects in total participated ...
Terashi Hiroo H aDepartments of - - 2014
Abstract Background: There is a need to define the basic characteristics of various kinematic parameters recorded during walking in patients with vascular parkinsonism (VP). The present study was designed to determine the kinematic features of walking in VP patients. For this purpose, gait acceleration and cycle were recorded continuously over ...
Celikoglu Mevlut M a Associate Professor, Department of Orthodontics, Faculty of Dentistry, Akdeniz University, Antalya, - - 2014
Objective: To evaluate the mandibular dental, alveolar, and skeletal transversal widths in patients affected by unilateral (UCLP) and bilateral (BCLP) cleft lip and palate and to compare the findings with a well-matched normal occlusion sample using cone beam computed tomography images. Materials and Methods: The study sample consisted of 75 ...
Siler Dominic A DA Department of Anesthesiology & Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, - - 2014
Patients recovering from aneurysmal subarachnoid hemorrhage (SAH) are at risk for developing delayed cerebral ischemia (DCI). Experimental and human studies implicate the vasoconstrictor P450 eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE) in the pathogenesis of DCI. To date, no studies have evaluated the role of vasodilator epoxyeicosatrienoic acids (EETs) in DCI. Using mass ...
van Lümig P P M PP Department of Dermatology, Radboud university medical center, Nijmegen, The - - 2014
Concerns exist about a risk of non-melanoma skin cancer (NMSC) in psoriasis patients and rheumatoid arthritis (RA) patients treated with TNF-inhibitors. However, current data also show that in some psoriasis patients, NMSC is diagnosed relatively short after the start of TNF-inhibitors, which suggests that these NMSC can be explained by ...
Degirmenci Eylem E Department of Neurology, School of Medicine, Pamukkale University, Denizli, Turkey, - - 2014
Hemifacial spasm (HFS) is defined as an involuntary, irregular clonic, or tonic movement of muscles innervated by the ipsilateral seventh cranial nerve. It is reported that the coexistence of non-motor- and motor-related symptoms can be seen in patients with HFS. Postural disturbances were investigated in some movement disorders; however, postural ...
Athlin Simon S Department of Infectious Diseases, Örebro University Hospital, Sweden - - 2014
We studied the immunoglobulin (Ig) response to causative serotype-specific capsular polysaccharides in adult pneumococcal pneumonia patients. Serotypes were grouped according to degree of encapsulation and invasive potential. Seventy patients with pneumococcal pneumonia, 20 of whom were bacteremic, were prospectively studied. All pneumococcal isolates were serotyped and Ig titers to the ...
Arevalo-Manso Juan Jose JJ Department of Neurology and Stroke Centre, La Paz University Hospital; IdiPAZ, Hospital La Paz Institute for Health Research; Autonomous University of Madrid, Spain jjarevaloes@hotmail.com - - 2014
It is unknown whether monitors that include atrial fibrillation recognition software (AF-RS) increase the rate of early atrial fibrillation (AF) detection in acute stroke. We aimed to evaluate the AF detection rate of an AF-RS monitor and compare it with standard monitoring. This was a retrospective, single-centre observational study conducted ...
Del Valle Elisa E Department of Nephrology, Instituto de Investigaciones Metabólicas, Buenos Aires, - - 2014
Controversy exists on which vitamin D (D2 or D3) and which dosage scheme is the best to obtain and maintain adequate 25 OH D levels in dialysis patients safely. We tried to determine whether high-dose vitamin D2 supplementation could obtain optimal vitamin D status without inducing hypercalcemia. We studied 82 ...
Matika Ryan W RW Departments of Anesthesiology, * and Medicine, † the University of Arizona College of - - 2014
Chronic hemodialysis is associated with significant thrombophilia. Of interest, hemodialysis patients have increased carboxyhemoglobin and exhaled carbon monoxide (CO), signs of upregulated heme oxygenase (Hmox) activity. Given that CO enhances plasmatic coagulation, we determined if patients requiring chronic hemodialysis had an increase in endogenous CO, plasmatic hypercoagulability and decreased fibrinolytic ...
Wolff Anette S B AS Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; - - 2014
Patients with the autoimmune polyendocrine syndrome type I (APS-I), caused by mutations in the autoimmune regulator (AIRE) gene, and myasthenia gravis (MG) with thymoma, show intriguing but unexplained parallels. They include uncommon manifestations like autoimmune adrenal insufficiency (AI), hypoparathyroidism, and chronic mucocutaneous candidiasis plus autoantibodies neutralizing IL-17, IL-22, and type ...
Chen G G 1] Department of Urology, China Rehabilitation Research Center, Beijing, China [2] Department of Urology, Capital Medical University, Beijing, - - 2014
Study design:Retrospective case series.Objectives:The primary aim was to assess the clinical effects of sacral neuromodulation (SNM) for neurogenic bladder and/or bowel dysfunction with multiple symptoms secondary to spinal cord disease or injury.Setting:Beijing, China.Methods:Between 2011 and 2013, 23 patients with multiple bladder and/or bowel problems secondary to spinal cord disease or ...
Unal Hilmi Umut HU Department of Nephrology - - 2014
Abstract Objective: To determine the relationships between inflammatory mediators, mitral annular calcification (MAC), and osteocalcin in patients with chronic kidney disease (CKD). Materials and methods: Echocardiographic data for 60 patients diagnosed as CKD were retrospectively evaluated. The patients were divided into 2 groups; patients with MAC (MAC+ group) and patients ...
Saedon M M University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK; Warwick Medical School, University of Warwick, Coventry, - - 2014
Transient cerebral microemboli are independent biomarkers of early risk of ischaemic stroke in acute carotid syndromes. Transcranial Doppler imaging (TCD) through the temporal bone is the standard method for detection of cerebral microemboli, but an acoustic temporal bone window for TCD is not available in around one in seven patients. ...
Joo Young-Hoon YH Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, - - 2014
Background: To evaluate the long-term swallowing function in patients with vertical hemipharyngolaryngectomy (VHPL) for hypopharyngeal cancer. Methods: A retrospective review of 30 patients followed for more than 2 years with VHPL between 1998 and 2011 was performed. Results: Five patients (16.7%) experienced gastrostomy tube placement, 4 patients (13%) pharyngoesophageal stricture, ...
Wigand Marlene M Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , - - 2014
Objectives. The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are likely relevant to the pathogenesis of auditory verbal hallucinations (AVHs). The aim of this study was to examine this ...
Del Sorbo Lorenzo L 1Dipartimento di Anestesiologia e Rianimazione, Azienda Ospedaliera Città della Salute e della Scienza e di Torino, Università di Torino, Torino, Italy. 2Respiratory and Critical Care Unit, Department of Specialist, Diagnostic and Experimental Medicine (DIMES), Sant'Orsola Malpighi Hospital, Alma Mater University, Bologna, Italy. 3Thoracic Surgery Unit, Sant'Orsola Malpighi Hospital, Alma Mater University, Bologna, Italy. 4Unit of Clinical Epidemiology, Azienda Ospedaliera Città della Salute e della Scienza e di Torino and CPO Piemonte, Torino, Italy. 5Dipartimento di Emergenza ed Accettazione, Unità di Medicina d'Urgenza, Azienda Ospedaliera Città della Salute e della Scienza e di Torino, Università di Torino, Torino, - - 2014
To assess efficacy and safety of noninvasive ventilation-plus-extracorporeal CO2 removal in comparison to noninvasive ventilation-only to prevent endotracheal intubation patients with acute hypercapnic respiratory failure at risk of failing noninvasive ventilation. Matched cohort study with historical control. Two academic Italian ICUs. Patients treated with noninvasive ventilation for acute hypercapnic respiratory ...
Kumar Abhay A Department of Neurology, Saint Louis University, Saint Louis, MO, - - 2014
Intracranial hemorrhage (ICH) is not an uncommon complication of end-stage renal disease (ESRD), and may be complicated by cerebral edema. Hemodialysis (HD) may induce rapid osmolar and fluid shifts, increasing brain water content with the potential to worsen cerebral edema. The dangers of HD in patients with acute ICH have ...
Yri Hanne M HM Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, - - 2014
The aims of this article are to characterize the headache in idiopathic intracranial hypertension (IIH) and to field-test the ICHD diagnostic criteria for headache attributed to IIH. We included 44 patients with new-onset IIH. Thirty-four patients with suspected but unconfirmed IIH served as controls. Headache and other IIH-related symptoms were ...
Coppola Gianluca G Department of Neurophysiology of Vision and Neurophthalmology, G.B. Bietti Foundation-IRCCS, Italy - - 2014
We previously observed impaired habituation mechanisms of the conventional blink reflex (BR) in patients with episodic cluster headache (ECH) during the bout, studying only the affected side. Here, we have studied the nociceptive-specific BR (nBR) both on the affected and non-affected sides, and in relation to clinical features. We recorded ...
Amirghofran Zahra Z Department of Immunology, Autoimmune Disease Research Center and Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, - - 2014
CD44v6 is an isoform of CD44 that can be present in soluble form (sCD44v6). The aim of this study is to evaluate the presence of soluble CD44 (sCD44) and sCD44v6 in serum of children with B-cell precursor acute lymphoblastic leukemia (B-ALL) and their relationship with prognosis. sCD44v6 and sCD44 levels ...
Ceriana P P Respiratory Rehabilitation Unit, IRCCS Fondazione Maugeri, Pavia - - - 2014
Patients after tracheostomy often present swallowing dysfunctions but little is known about the mechanism underlying dysphagia and its reversibility. The aims of this study were: 1) to characterize swallowing dysfunctions in patients with dysphagia and tracheostomy;; 2) to evaluate the reversibility of these changes;; 3) to evaluate the possible influence ...
Kalsi J S JS Consultant Urological Surgeon, Heatherwood and Wexham Park Hospitals, Berkshire, Imperial College, London. - - 2014
To assess the outcome of m-TESEas a salvage treatment in men withnon-obstructive azoospermia (NOA) in whom no sperm was previously found on single/multiple TESE or TESA. A total of 58 men with NOA underwent micro-dissection testicular sperm extraction. All patients had previously undergone either single/multiple TESE or TESA with no ...
Kawamura Mitsuharu M Division of Cardiac Electrophysiology, University of California, San Francisco, San Francisco, CA - - 2014
-Idiopathic ventricular arrhythmia (VA) can arise from the epicardium near the posteroseptal region (cardiac-crux). There are only two prior reports describing idiopathic-VA from the cardiac crux. The purpose of this study was to characterize the clinical and the electrocardiographic features of idiopathic crux-VA. -Crux-VA were identified in 18 patients undergoing ...
Frasure Sarah E SE Department of Emergency Medicine, Brigham and Women's Hospital, USA - - 2014
The purpose of this study was to compare lung ultrasound findings in both the supine and upright positions in heart failure patients presenting with dyspnea or chest pain. We performed lung ultrasonography on 50 heart failure patients in the emergency department. Each subject underwent eight-zone lung sonography in the seated ...
Li Rui Jian RJ The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, P.R. China; Department of Emergency, Qilu Hospital of Shandong University, Jinan, Shandong, P.R. - - 2014
The chemokine fractalkine independently enhances the vulnerability of coronary atherosclerotic plaques. This study investigated the combined effects of CD36 and fractalkine on coronary plaque progression in patients with unstable angina pectoris (UAP). In this study, 120 UAP patients undergoing coronary angiography and intravascular ultrasound (IVUS) were divided into two groups: ...
Calzada Audrey P AP *House Ear Clinic, †Department of Radiology, University of Southern California; ‡Department of Pathology, St. Vincent Medical Center; and §House Clinic, Neurosurgery, Los Angeles, California, - - 2014
To describe the clinical and radiographic characteristics in a series of patients with non-vestibular schwannoma cerebellopontine angle (CPA) and intracanalicular (IAC) masses, who underwent microsurgery for presumed vestibular schwannoma (VS). Retrospective case series. Tertiary neurotologic referral center. One thousand five hundred ninety-three patients underwent microsurgery for apparent VS from 2002 ...
Rimmer Joanne J *Department of Otolaryngology and Audiological Medicine, Charing Cross Hospital, and †Division of Brain Sciences, Imperial College London, Charing Cross Hospital, London, United Kingdom; and ‡Department of Respiratory Medicine, Royal Brompton Hospital, London, United - - 2014
Patients with primary ciliary dyskinesia (PCD) have absent or reduced otoconial function compared to the normal population. Investigations in zebrafish show that ciliation is important for the development of the otolith organs, but this has never been evaluated in humans. PCD is a congenital defect of ciliary structure. We undertook ...
Wu Lung-Chi LC Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China; Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, Republic of China; National Defense Medical Center, Taipei, Taiwan, Republic of China; Department of Dermatology, National Yang-Ming University, Taipei, Taiwan, Republic of - - 2014
Atopic dermatitis (AD) is a chronic relapsing dermatitis of unknown etiology. It is thought that abnormal regulation of Th1 and Th2 is not only the major cause of AD, but also the vital pathogenesis of many autoimmune diseases. To date, no large-scale studies have been performed on the relationship between ...
Urbschat Anja A Faculty of Medicine, Philipps-University Marburg, Baldinger Strasse, 35043, Marburg, Germany, - - 2014
We investigated whether the recently established biomarkers of acute kidney injury, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), may help to diagnose acute urinary tract infections (UTI) in adults and are able to distinguish between upper or lower localization. NGAL levels were measured in blood and urine, and ...
Kaneko Yoshiaki Y Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan - - 2014
-Electrical storms (ES) in patients with Brugada syndrome (BrS) are rare though potentially lethal. -We studied 22 men with BrS and ES, defined as ≥3 episodes/day of ventricular fibrillation (VF) and compared their characteristics with those of 110 age-matched, control men with BrS without ES. BrS was diagnosed by a ...
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