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Sonoyama Takuhiro T Department of Medicine and Clinical ScienceKyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, - - 2014
We recently reported that stimulation with high-dose ACTH caused different responses in terms of aldosterone secretion in aldosterone-producing adenomas (APAs) and idiopathic hyperaldosteronism (IHA) in patients with primary aldosteronism (PA). However, the role of endogenous ACTH in aldosterone secretion in PA has not been systematically evaluated. In this study, we ...
Nicholson Andrew G AG Royal Brompton and Harefield NHS Foundation Trust, - - 2014
This presentation reviews the histopathology of the IIPs since the 2002 ATS/ERS classification of IIPs in the light of the 2013 update. The seven histological patterns proposed in 2002 remain, with diagnostic criteria refined but overall unchanged. A multidisciplinary approach is now established as best practice. NSIP is now recognised as ...
Ma Hui-Ping HP Department of Respiratory Medicine, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. - - 2014
Previous studies have revealed the role of matrix metalloproteinase 9 (MMP9) in asthma and chronic obstructive pulmonary disease (COPD). However, its role in airway inflammation in cough variant asthma (CVA) remains unknown. In the present study, variations in the levels of MMP9 and interleukin (IL)-5 in the induced sputum of ...
Long Yan-Yan YY Department of Medical Oncology, Chinese PLA General Hospital, Beijing 100853, P.R. China ; Medical School of Nankai University, Tianjin 300071, P.R. - - 2014
NY-ESO-1 has been identified as one of the most immunogenic antigens; thus, is a highly attractive target for cancer immunotherapy. The present study analyzed the expression of serum antibodies (Abs) against NY-ESO-1 in patients with advanced colorectal cancer (CRC), with the aim of guiding the treatment of NY-ESO-1-based specific-immunotherapy for ...
Bártová Petra P Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic. Electronic address: - - 2014
Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and (123)I-FP-CIT ([(123)I]ioflupane, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123)I]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of ...
Wen Xue X Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. - - 2014
Signet ring cell carcinoma (SRC) of the ampulla of Vater is extremely rare and the histogenesis remains unknown. In the present study, to investigate the immunohistochemical phenotypes, discuss the histological origin and evaluate the correlation between the immunohistochemical phenotypes and survival of ampullary SRC patients, a retrospective review was conducted. ...
Han Michelle S MS Department of Surgery, University of Rochester Medical Center, University of Rochester, 601 Elmwood Avenue, Box SURG, Rochester, NY 14642, - - 2014
The development and advancement of ambulatory esophageal pH monitoring has provided a key tool with which pathologic esophageal acid exposure can be objectively measured; although not perfect, it provides the clinician with arguably the most important piece of information in the diagnosis and management of patients with gastroesophageal reflux disease. ...
Lin Tess E TE Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina (UNC) at Chapel Hill, CB#7355, 301 Pharmacy Lane, Chapel Hill, NC 27599-7355, - - 2014
Hyponatremia is a known complication in patients with heart failure (HF). HF patients with severe congestion, hyponatremia, and renal insufficiency are difficult to manage and may have worse outcomes. A main cause of hyponatremia is inappropriately elevated level of plasma arginine vasopressin (AVP), which causes water retention at the collecting ...
Kim Chang-Hee CH *Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea; and †Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
To characterize the clinical features of patients who simultaneously developed ipsilateral sudden sensorineural hearing loss (SSNHL) and positional vertigo showing geotropic direction-changing positional nystagmus (DCPN) on a supine head-roll test, and to address the possible pathophysiology of the disease. Retrospective case series review. We conducted a retrospective case series study ...
Ribeiro Sle S Department of Medical Clinic; Faculty of Medicine, Universidade Federal do Amazonas, Manaus, Brazil - - 2014
β2 glycoprotein I (β2GPI) is a phospholipid binding protein that plays an important role in endothelial stability, blood coagulation, clearance of apoptotic debris and other physiologic processes. Anti-β2GPI antibodies occur in normal individuals and transiently during the course of infections, but are also associated with thrombotic events in autoimmune disease: ...
Dall'Ara F F Department of Clinical and Experimental Science, University of Brescia, Italy Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Italy - - 2014
To assess the prevalence of disease- and therapy-related complications and of the organ damage after a follow-up of 15 years or more in patients with primary antiphospholipid syndrome (PAPS). Medical records of patients prospectively followed in our centre for at least 15 years were retrospectively reviewed. Thirty-five Caucasian patients (33 ...
Han Xiang Y XY From the Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston; - - 2014
To differentiate the leprosy agents Mycobacterium leprae and Mycobacterium lepromatosis and correlate them with geographic distribution and clinicopathologic features. Species-specific polymerase chain reactions were used to detect each bacillus in archived skin biopsy specimens from patients with leprosy from Brazil (n = 52), Malaysia (n = 31), Myanmar (n = ...
Rajaei Mohammad H MH Department of Surgery, University of Wisconsin, Madison, - - 2014
Intraoperative parathyroid hormone (ioPTH) monitoring during focused parathyroidectomy for primary hyperparathyroidism (PHPT) is used commonly, but some argue that ioPTH adds little if a normal ipsilateral parathyroid gland (IPG) is visualized. This hypothesis was tested for validity. The prospective databases of consecutive patients with PHPT undergoing initial parathyroidectomy with ioPTH ...
Connelly Tara M TM Department of Surgery, Division of Colon & Rectal Surgery, The Pennsylvania State University, Hershey, - - 2014
Clinical studies have suggested that patients with inflammatory bowel disease (IBD) are at greater risk for developing Clostridium difficile infection (CDI). The purpose of this study was to identify single-nucleotide polymorphisms (SNPs) associated with CDI among IBD patients. This retrospective cohort study used our biobank to compare patients with IBD ...
Onders Raymond P RP University Hospitals Case Medical Center, Cleveland, OH. Electronic address: - - 2014
Diaphragm dysfunction (DD) can cause sleep abnormalities, dyspnea, atelectasis, and respiratory failure. Historical treatments, including positive pressure ventilation or diaphragm plication, may alleviate symptoms but do not restore physiologic diaphragm function. Diaphragm pacing (DP) is approved for spinal cord-injured patients and in amyotrophic lateral sclerosis. We report a series of ...
Velasco-Rodríguez Diego D From the Laboratorio Central de la Comunidad de Madrid, Madrid, Spain, and - - 2014
To analyze the differences not only in classic hematologic parameters but also in RBC subpopulations among δβ-thalassemia trait (δβ-TT), β-thalassemia trait (β-TT), and iron deficiency anemia (IDA) and to evaluate the role of fetal hemoglobin (HbF) in elevated RBC distribution width (RDW). Samples from 553 patients with microcytosis (74 δβ-TT, ...
Birsen Onur O Department of Endocrine Surgery, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, - - 2014
Although adrenal incidentalomas (AI) are detected in ≤5% of patients undergoing chest and abdominal computed tomography (CT), their management is challenging. The current guidelines include recommendations from the National Institutes of Health, the American Association of Endocrine Surgeons (AAES), and the American Association for Cancer Education (AACE). The aim of ...
Yilmaz Hakki H Department of Internal Medicine, Section of Nephrology, School of Medicine, Turgut Ozal University , Ankara , Turkey - - 2014
Abstract Objectives: Primary cause of late arteriovenous fistula (AVF) dysfunction is venous stenosis as result of neointimal hyperplasia. The mechanism of AVF stenosis is not exactly understood. But inflammation is a contributing factor for development of AVF stenosis. Neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, and it was investigated in many ...
Unverdi Selman S Department of Nephrology, Ankara Educational and Training Hospital , Ankara , Turkey - - 2014
Abstract Background/Aim: Oral essential amino acids (AAs) containing supplements (EAS) and AA containing dialysate (ACD) are frequently used in peritoneal dialysis (PD) patients with malnutrition. The present study was conducted to investigate two strategies and compare their effects on the malnutrition status of PD patients. A total of 31 EAS, ...
Saindane Amit M AM 1 Department of Radiology and Imaging Sciences, Emory University School of Medicine, BG22, 1364 Clifton Rd NE, Atlanta, GA - - 2014
OBJECTIVE. Transverse sinus stenosis is an imaging finding very highly associated with elevated intracranial pressure (ICP). Patients with the Chiari I malformation may potentially have elevated ICP due to impairment of CSF flow at the foramen magnum. This study evaluated whether patients with Chiari I malformation have transverse sinus stenosis ...
D'Anastasi Melvin M 1 Institute for Clinical Radiology, University Hospitals Munich, Campus Grosshadern, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377 Munich, Bayern, - - 2014
OBJECTIVE. Beta-2-microglobulin is a serum maker of tumor burden in hematologic malignancies. We aimed to correlate serum β2-microglobulin levels in patients with multiple myeloma (MM) to tumor mass determined by whole-body MRI. MATERIALS AND METHODS. We retrospectively included patients with newly diagnosed, untreated MM who underwent whole-body MRI at our ...
Uchida Toyoyoshi T Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan. - - 2014
The purpose of this study was to assess the frequency and sonographic and laboratory characteristics of Graves disease with intrathyroid hypovascularity in Japanese patients and to compare these characteristics in patients with painless thyroiditis. A total of 194 consecutive patients with Graves disease and 21 patients with painless thyroiditis were ...
Stroz Marianne J MJ Department of Diagnostic Imaging, Mackenzie Health, 10 Trench St., Richmond Hill, ON, Canada L4C 4Z3.. Electronic address: - - 2014
Cognitively impaired patients often pull at their dialysis catheters when the catheters are tunneled over the anterior chest. To potentially circumvent this, a technique was developed that tunnels the catheter posteriorly, over the patient's shoulder. A total of 32 posteriorly tunneled catheters were placed in 12 patients. The mean catheter ...
Ricotta Joseph J JJ 2nd Northside Hospital Heart and Vascular Institute, Atlanta, - - 2014
Data on the influence of contralateral carotid occlusion (CCO) on carotid endarterectomy (CEA) are conflicting and are absent for carotid artery stenting (CAS). This study evaluated the influence of CCO on CEA and CAS. We evaluated patients with and without CCO in the Society for Vascular Surgery Vascular Registry. Primary ...
Yucel H H Department of Cardiology, Cumhuriyet University Medical School, Sivas, - - 2014
Elevated cancer antigen 125 (CA-125) levels are associated with cardiopulmonary disorders such as acute and chronic heart failure (HF), coronary artery disease, chronic obstructive pulmonary disease, and atrial fibrillation (AF). The development of atrial fibrillation (AF) is related to morbidity and mortality in patients with HF: therefore, it is important ...
Haflidadottir Svanhildur - - 2014
Few studies have compared the prognosis and liver-related mortality in patients with NAFLD (nonalcoholic fatty liver disease) and AFLD (alcoholic fatty liver disease). We aimed to investigate the etiology and liver-related mortality of patients with liver biopsy verified fatty liver disease in a population based setting. In this retrospective study, ...
Comunello A A DIMED, Padua University Hospital, Padua, - - 2014
Cardiovascular complications, including arrhythmias and cardiac sudden death, are the most common causes of enhanced mortality in acromegaly. However, few data are available on cardiac autonomic functions and sympathovagal balance in acromegalic patients. The aim of this study was to investigate both the time and frequency domain parameters of Heart ...
Eick Sigrun - - 2014
BackgroundLoss-of-function point mutations in the cathepsin C gene are the underlying genetic event in patients with Papillon-Lefèvre syndrome (PLS). PLS neutrophils lack serine protease activity essential for cathelicidin LL-37 generation from hCAP18 precursor.AimWe hypothesized that a local deficiency of LL-37 in the infected periodontium is mainly responsible for one of ...
Joosten Etienne E Department of Internal Medicine, Division of Geriatric Medicine, University Hospitals Leuven, Leuven, - - 2014
Anemia is an important clinical problem in older patients. The aim of the present study was to investigate whether comorbidities as an additional explanation for the severity of the anemia are frequent, and might help to explain the anemia severity in older patients with iron deficiency anemia (IDA) and the ...
Terzi Hasan H Obstetrics and Gynecology Clinic, Derince Education and Research Hospital, Kocaeli, - - 2014
The aim of this study was to determine whether pre-eclampsia is a risk factor for cochlear damage and sensorineural hearing impairment. This prospective case-control study consisted of 33 patients with pre-eclampsia and 32 normotensive pregnant patients as controls. All of the subjects underwent otoscopic examinations - pure tone audiometry (0.25-16 kHz) ...
Landerholm Kalle K Department of Surgery, Ryhov County Hospital, SE-551 85, Jönköping, Sweden, - - 2014
To investigate whether celiac disease risk haplotypes HLA-DQ2 and DQ8 also increase the risk for developing small intestinal neuroendocrine tumor (SI-NET). Thirty-five patients with serotonin-producing jejunal and ileal SI-NET were examined with HLA-DQ genotyping and serology for IgA anti-tissue transglutaminase (tTG) antibodies. Twenty-one patients (60 %) carried HLA-DQ2 or DQ8, twice ...
Prachayakul Varayu - - 2014
Diagnosis of choledocholithiasis requires clinical manifestations and imaging examination findings suggesting a stone in the common bile duct (CBD), but these factors are not highly sensitive or specific. The choledocholithiasis management algorithm proposed by the American Society for Gastrointestinal Endoscopy (ASGE) may not be appropriate for patients who fulfill the ...
Welling Lindsey L Division of Metabolic Diseases (H7-270), Department of Pediatrics and Amsterdam Lysosome Center "Sphinx", Academic Medical Center (AMC), University of Amsterdam, ZIP code 22660, 1100 DD, Amsterdam, The - - 2014
Mucopolysaccharidosis type III (MPS III), or Sanfilippo disease, is a neurodegenerative lysosomal storage disease (LSD) caused by defective lysosomal degradation of heparan sulfate (HS). No effective disease-modifying therapy is yet available. In contrast to some other neuronopathic LSDs, bone marrow-derived hematopoietic stem cell transplantation (HSCT) fails to prevent neurological deterioration ...
Wang Jian J Department of Cardiology, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Chinese Ministry of Education and Chinese Ministry of Health , Jinan , China - - 2014
Abstract Objectives: To investigate the association between serum uric acid and mortality in a Chinese population of hypertensive patients. Methods and results: A total of 2757 Chinese hypertensive patients from department of cardiology of several hospitals in Shanghai in China were followed up for about six years in this prospective ...
Takei Yuji Y Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, - - 2014
Lobular endocervical glandular hyperplasia (LEGH) is histologically similar to minimal deviation adenocarcinoma (MDA), but classified as a benign disease. Although MDA often develops in Peutz-Jeghers syndrome (PJS) patients, there have been only a few reports on PJS with LEGH. We report a PJS patient who was diagnosed with LEGH by ...
Nakamura Yutaka Y Department of Orthopaedic Surgery, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan, - - 2014
Patients with Prader-Willi syndrome (PWS) have fragile bones. Osteoporosis is a major concern in scoliosis surgery. Our aim was to investigate bone mineral density (BMD) in PWS patients and to verify the efficacy of and scoliosis deterioration with growth hormone (GH) administration for osteoporosis. We followed 148 PWS patients who ...
Karalezli A A Department of Ophthalmology, Baskent University School of Medicine, Konya, - - 2014
PurposeThe purpose of this study was to assess choroidal thickness in migraine patients during acute migraine attacks and compare them with healthy controls, using spectral domain optical coherence tomography (OCT).Patients and methodsIn this prospective case-control study, choroidal thicknesses of 46 migraine patients during acute migraine attacks and 46 age- and ...
Thompson Eric M EM Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada; - - 2014
Object Radionuclide shuntography interpretation is uncertain when the tracer fails to enter the ventricles but quickly drains distally or when the tracer enters the ventricles but takes longer than 15 minutes to drain distally. The purpose of this study was to aid in the clinical interpretation of a variety of ...
Phillips David B DB Section of Neurosurgery - - 2014
Object In this report, the authors describe the pathological changes in the human trigeminal nerve after Gamma Knife radiosurgery. Methods Three trigeminal nerves of patients with multiple sclerosis (MS)-related trigeminal neuralgia (MSTN) after Gamma Knife radiosurgery and other ablative procedures were examined by a neuropathologist. These cases were compared with ...
Rocca Maria A MA Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, - - 2014
Aim of this study was to explore the topological organization of functional brain network connectivity in a large cohort of multiple sclerosis (MS) patients and to assess whether its disruption contributes to disease clinical manifestations. Graph theoretical analysis was applied to resting state fMRI data from 246 MS patients and ...
Magrì Damiano D Department of Clinical and Molecular Medicine, "La Sapienza" University of Rome, Italy Centro Cardiologico Monzino, IRCCS, - - 2014
Oxygen uptake at the anaerobic threshold (VO2AT), a submaximal exercise-derived variable, independent of patients' motivation, is a marker of outcome in heart failure (HF). However, previous evidence of VO2AT values paradoxically higher in HF patients with permanent atrial fibrillation (AF) than in those with sinus rhythm (SR) raised uncertainties. We ...
Ayesh Haj Yousef Mahmoud Husni - - 2014
We conducted this study to determine the erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity level in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) and to determine the effect of hemodialysis adequacy on G6PD activity levels and its impact on anemia. Eighty-two patients (48 men and 34 women) receiving regular ...
McKeon Andrew A From the Departments of Laboratory Medicine and Pathology (A.M., V.A.L., S.J.P., T.J.K.), Neurology (A.M., V.A.L., S.J.P.), Immunology (V.A.L., J.M.), and Gastroenterology (J.M.), College of Medicine, Mayo Clinic, Rochester, MN. - - 2014
To report neurologic phenotypes and their etiologies determined among 68 patients with either (1) celiac disease (CD) or (2) no CD, but gliadin antibody positivity (2002-2012). Neurologic patients included both those with the CD-prerequisite major histocompatibility complex class II human leukocyte antigen (HLA)-DQ2/DQ8 haplotype, and those without. The 3 groups ...
Gromadziński Leszek L Department of Internal Diseases, Gastroenterology and Hepatology, University Clinical Hospital in Olsztyn, ul. Warszawska 30, 10-082, Olsztyn, Poland, - - 2014
The increased value of the red cell distribution width (RDW) was reported to indicate poor prognosis in patients with chronic heart failure. We evaluated the value of the RDW in the diagnosis of left ventricular diastolic dysfunction (LVDD) in patients without diastolic heart failure among the chronic kidney disease (CKD) ...
Ohsawa Isao I Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, - - 2014
Background: Hereditary angioedema (HAE) is a rare but life-threatening condition that results from mutations in C1-inhibitor (C1-INH). Since distinguishing HAE from other causes of angioedema (AE) is a critical problem in emergencies, the objective of the present study was to clarify the differences between HAE and other forms of AE. ...
Aota Takumi T Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, - - 2014
Prevention of deep vein thrombosis (DVT) is important in patients undergoing major orthopedic surgery. Although the detection of an elevated D-dimer level is useful for predicting DVT, it is not efficacious in postoperative patients being treated with anti-Xa agents. The soluble platelet glycoprotein VI (sGPVI) level is a marker of ...
Miao Xutao X Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, - - 2014
Magnetic resonance imaging (MRI) and chemosensory event-related potentials (ERPs) are important methods to evaluate olfactory function, but there is lack of study to explore the application of MRI and chemosensory ERPs in the patients with traumatic anosmia. The data of 26 post-traumatic anosmic patients and 21 healthy controls were retrospectively ...
AlShardan Mohammad M MM King Fahad Medical City, King Saud Bin Abdulaziz University for Health Sciences, Faculty of Medicine, Department of Neurosurgery , Riyadh , Kingdom of Saudi - - 2014
Objective. To evaluate potential risk factors that can predict the development of hydrocephalus (HCP) in adult patients with intraventricular hemorrhage (IVH). Methods. Retrospective analysis of all adult patients presented to King Fahad Medical City between 2004 and 2011 with intraventricular hemorrhage to evaluate different variables and their association with HCP. ...
Slingerland Marije M Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands, - - 2014
To evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and varying degrees of hepatic function. Patients with advanced solid malignancies, acceptable bone marrow and renal function, and normal or impaired hepatic function, per NCI-ODWG criteria, were eligible. Initially patients received a single oral dose ...
Schuetz Philipp - - 2014
Abstract Plasma proadrenomedullin (ProADM) is a blood biomarker that may aid in multidimensional risk assessment of patients with chronic obstructive pulmonary disease (COPD). Co-secreted 1:1 with adrenomedullin (ADM), ProADM is a less biologically active, more chemically stable surrogate for this pluripotent regulatory peptide, which due to biological and ex vivo ...
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