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Valdivielso Pedro P Department of Medicine and Dermatology, University of Malaga, Spain; Servicio de Medicina Interna, Hospital Virgen de la Victoria, Malaga, - - 2014
Severe hypertriglyceridemia (HTG) is a well established and the most common cause of acute pancreatitis (AP) after alcohol and gall stone disease. It is alleged to account for up to 10% of all pancreatitis episodes. Studies suggest that in patients with triglyceride (TG) levels>1000mg/dL (>11.3mmol/L), hypertriglyceridemia-induced acute pancreatitis (HTGP-AP) occurs ...
Tüzün Erdem E Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, - - 2014
Background/Methods: To find out the prevalence of aquaporin-antibody (Aqp-Ab) and characterize Aqp-Ab associated clinical features in NMO, Aqp-1 and Aqp-4-Abs were examined using radioimmunoprecipitation and cell-based assays, respectively. Results: Aqp-4 and Aqp-1-Abs were detected in 20/30 and 8/30 NMO patients, respectively. One patient was Aqp-1-Ab single-positive, 13 patients were Aqp-4-Ab ...
Akbulut Sami S Sami Akbulut, Rıdvan Yavuz, Department of Surgery, Diyarbakir Education and Research Hospital, Uckuyular Mevki, Kayapinar, 21400 Diyarbakir, - - 2014
To provide an overview of the literature on pancreatic extragastrointestinal stromal tumors (EGISTs). We report a case of pancreatic EGIST and review published studies on pancreatic EGIST accessed via the PubMed, MEDLINE, Google Scholar, and Google databases. The keywords used were "pancreas and GIST", "pancreas and extra GIST", "pancreas and ...
Eick Sigrun - - 2014
BackgroundLoss-of-function point mutations in the cathepsin C gene are the underlying genetic event in patients with Papillon-Lefèvre syndrome (PLS). PLS neutrophils lack serine protease activity essential for cathelicidin LL-37 generation from hCAP18 precursor.AimWe hypothesized that a local deficiency of LL-37 in the infected periodontium is mainly responsible for one of ...
Haflidadottir Svanhildur - - 2014
Few studies have compared the prognosis and liver-related mortality in patients with NAFLD (nonalcoholic fatty liver disease) and AFLD (alcoholic fatty liver disease). We aimed to investigate the etiology and liver-related mortality of patients with liver biopsy verified fatty liver disease in a population based setting. In this retrospective study, ...
Joosten Etienne E Department of Internal Medicine, Division of Geriatric Medicine, University Hospitals Leuven, Leuven, - - 2014
Anemia is an important clinical problem in older patients. The aim of the present study was to investigate whether comorbidities as an additional explanation for the severity of the anemia are frequent, and might help to explain the anemia severity in older patients with iron deficiency anemia (IDA) and the ...
Terzi Hasan H Obstetrics and Gynecology Clinic, Derince Education and Research Hospital, Kocaeli, - - 2014
The aim of this study was to determine whether pre-eclampsia is a risk factor for cochlear damage and sensorineural hearing impairment. This prospective case-control study consisted of 33 patients with pre-eclampsia and 32 normotensive pregnant patients as controls. All of the subjects underwent otoscopic examinations - pure tone audiometry (0.25-16 kHz) ...
Landerholm Kalle K Department of Surgery, Ryhov County Hospital, SE-551 85, Jönköping, Sweden, - - 2014
To investigate whether celiac disease risk haplotypes HLA-DQ2 and DQ8 also increase the risk for developing small intestinal neuroendocrine tumor (SI-NET). Thirty-five patients with serotonin-producing jejunal and ileal SI-NET were examined with HLA-DQ genotyping and serology for IgA anti-tissue transglutaminase (tTG) antibodies. Twenty-one patients (60 %) carried HLA-DQ2 or DQ8, twice ...
Welling Lindsey L Division of Metabolic Diseases (H7-270), Department of Pediatrics and Amsterdam Lysosome Center "Sphinx", Academic Medical Center (AMC), University of Amsterdam, ZIP code 22660, 1100 DD, Amsterdam, The - - 2014
Mucopolysaccharidosis type III (MPS III), or Sanfilippo disease, is a neurodegenerative lysosomal storage disease (LSD) caused by defective lysosomal degradation of heparan sulfate (HS). No effective disease-modifying therapy is yet available. In contrast to some other neuronopathic LSDs, bone marrow-derived hematopoietic stem cell transplantation (HSCT) fails to prevent neurological deterioration ...
Wang Jian J Department of Cardiology, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Chinese Ministry of Education and Chinese Ministry of Health , Jinan , China - - 2014
Abstract Objectives: To investigate the association between serum uric acid and mortality in a Chinese population of hypertensive patients. Methods and results: A total of 2757 Chinese hypertensive patients from department of cardiology of several hospitals in Shanghai in China were followed up for about six years in this prospective ...
Takei Yuji Y Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, - - 2014
Lobular endocervical glandular hyperplasia (LEGH) is histologically similar to minimal deviation adenocarcinoma (MDA), but classified as a benign disease. Although MDA often develops in Peutz-Jeghers syndrome (PJS) patients, there have been only a few reports on PJS with LEGH. We report a PJS patient who was diagnosed with LEGH by ...
Nakamura Yutaka Y Department of Orthopaedic Surgery, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan, - - 2014
Patients with Prader-Willi syndrome (PWS) have fragile bones. Osteoporosis is a major concern in scoliosis surgery. Our aim was to investigate bone mineral density (BMD) in PWS patients and to verify the efficacy of and scoliosis deterioration with growth hormone (GH) administration for osteoporosis. We followed 148 PWS patients who ...
Karalezli A A Department of Ophthalmology, Baskent University School of Medicine, Konya, - - 2014
PurposeThe purpose of this study was to assess choroidal thickness in migraine patients during acute migraine attacks and compare them with healthy controls, using spectral domain optical coherence tomography (OCT).Patients and methodsIn this prospective case-control study, choroidal thicknesses of 46 migraine patients during acute migraine attacks and 46 age- and ...
Thompson Eric M EM Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada; - - 2014
Object Radionuclide shuntography interpretation is uncertain when the tracer fails to enter the ventricles but quickly drains distally or when the tracer enters the ventricles but takes longer than 15 minutes to drain distally. The purpose of this study was to aid in the clinical interpretation of a variety of ...
Phillips David B DB Section of Neurosurgery - - 2014
Object In this report, the authors describe the pathological changes in the human trigeminal nerve after Gamma Knife radiosurgery. Methods Three trigeminal nerves of patients with multiple sclerosis (MS)-related trigeminal neuralgia (MSTN) after Gamma Knife radiosurgery and other ablative procedures were examined by a neuropathologist. These cases were compared with ...
Rocca Maria A MA Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, - - 2014
Aim of this study was to explore the topological organization of functional brain network connectivity in a large cohort of multiple sclerosis (MS) patients and to assess whether its disruption contributes to disease clinical manifestations. Graph theoretical analysis was applied to resting state fMRI data from 246 MS patients and ...
Magrì Damiano D Department of Clinical and Molecular Medicine, "La Sapienza" University of Rome, Italy Centro Cardiologico Monzino, IRCCS, - - 2014
Oxygen uptake at the anaerobic threshold (VO2AT), a submaximal exercise-derived variable, independent of patients' motivation, is a marker of outcome in heart failure (HF). However, previous evidence of VO2AT values paradoxically higher in HF patients with permanent atrial fibrillation (AF) than in those with sinus rhythm (SR) raised uncertainties. We ...
McKeon Andrew A From the Departments of Laboratory Medicine and Pathology (A.M., V.A.L., S.J.P., T.J.K.), Neurology (A.M., V.A.L., S.J.P.), Immunology (V.A.L., J.M.), and Gastroenterology (J.M.), College of Medicine, Mayo Clinic, Rochester, MN. - - 2014
To report neurologic phenotypes and their etiologies determined among 68 patients with either (1) celiac disease (CD) or (2) no CD, but gliadin antibody positivity (2002-2012). Neurologic patients included both those with the CD-prerequisite major histocompatibility complex class II human leukocyte antigen (HLA)-DQ2/DQ8 haplotype, and those without. The 3 groups ...
Abd El-Rehim Dalia M DM Departments of *Pathology †Tropical Medicine, Faculty of Medicine, Minia University, El-Minia, - - 2014
Data are limited regarding the role of proteinase-activated receptor-2 (PAR-2) in the esophageal mucosa in gastroesophageal reflux disease (GERD) patients. Our aim was to study PAR-2 expression and its relationship with different GERD-related clinical and pathologic parameters. Histomorphologic alterations in eosophageal mucosa in nonerosive reflux disease (NERD) and erosive reflux ...
Muto M M Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Several symptoms and signs are characteristic of multiple sclerosis (MS) such as Lhermitte's sign, Uhthoff's phenomenon and painful tonic seizure. Neuromyelitis optica (NMO) is another inflammatory disease of the central nervous system, and most of the opticospinal form of MS is thought to be NMO. This study aimed to investigate ...
Ingegnoli Francesca F Division of Rheumatology, Istituto Gaetano Pini, Department of Clinical Sciences & Community Health, University of Milano, Piazza cardinal Ferrari 1, Milano, Italy. Electronic address: - - 2014
Raynaud's phenomenon (RP) is a reversible vasospastic response of the extremities to cold or emotion, and can be the first manifestation or may be present before the development of an overt systemic sclerosis (SSc).The disturbance of the balance between vasodilation and vasoconstriction is not limited to the peripheral microcirculation of ...
Oliva Salvatore S Department of Pediatrics, Paediatric Gastroenterology Unit, Sapienza - University of Rome, Rome, - - 2014
This prospective single-centre study aims to evaluate a new diagnostic algorithm using capsule endoscopy, colon capsule endoscopy and single-balloon enteroscopy in the work-up of obscure gastrointestinal bleeding in children. The usefulness of a new diagnostic algorithm was assessed comparing the clinically relevant findings revealed by each technique, and evaluating the ...
Saksens Nicole T M NT Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The - - 2014
To describe the clinical characteristics and long-term follow-up in patients with autosomal dominant cystoid macular dystrophy (DCMD). Retrospective case series. Ninety-seven patients with DCMD. Extensive ophthalmic examination, including visual acuity (VA), fundus photography, fluorescein angiography (FA), fundus autofluorescence (FAF) imaging, optical coherence tomography (OCT), color vision testing, dark adaptation testing, ...
Hassan S M SM Molecular Genetic Laboratory, Genetic Centre, Muscat, Sultanate of Oman; The Reference Hemoglobinopathies Laboratory, dept. of Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address: - - 2014
We report the general phenotype severity and the hematological presentation in a cohort of 125 sickle cell anemia (SCA) patients with identical homozygous HbS/S genotype and categorized by identical β(S) haplotype, both with and without alpha thalassemia. No clear general phenotype correlation was found when patients were compared regardless of ...
Prachayakul Varayu - - 2014
Diagnosis of choledocholithiasis requires clinical manifestations and imaging examination findings suggesting a stone in the common bile duct (CBD), but these factors are not highly sensitive or specific. The choledocholithiasis management algorithm proposed by the American Society for Gastrointestinal Endoscopy (ASGE) may not be appropriate for patients who fulfill the ...
Ayesh Haj Yousef Mahmoud Husni - - 2014
We conducted this study to determine the erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity level in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) and to determine the effect of hemodialysis adequacy on G6PD activity levels and its impact on anemia. Eighty-two patients (48 men and 34 women) receiving regular ...
Kamper Lars L Department of Diagnostic and Interventional Radiology, Urology HELIOS Medical Center Wuppertal, University Hospital Witten/Herdecke, Wuppertal, Germany; Center for Clinical Medicine, Witten/Herdecke University Faculty of Health, Wuppertal, Germany. - - 2014
We aimed to evaluate diffusion-weighted imaging (DWI) findings in patients with treated and untreated retroperitoneal fibrosis (RPF). We analyzed magnetic resonance imaging examinations of 44 RPF patients (36 male, 8 female), of which 15 were untreated and 29 were under therapy. Qualitative DWI and T1 postcontrast signal intensities and the ...
Gönül Müzeyyen M Dermatology Clinic, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, - - 2014
Pigmented purpuric dermatoses (PPD) are chronic, recurrent group of disorders characterized by petechial and pigmentary macules usually localized on the lower limbs. Its etiopathogenesis is unknown. There are very few clinical and etiological studies on PPD in the literature. We aim to examine the etiopathogenetic factors of PPD retrospectively. Demographic ...
Sipahioglu Nurver Turfaner NT Nurver Turfaner Sipahioglu, Fikret Sipahioglu, Department of Family Medicine, Cerrahpasa Medical Faculty, Istanbul University, 34303 Istanbul, - - 2014
This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension (WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. Studies were included if the WCHT patients were defined according to the 2013 European Society of Hypertension guidelines, ...
Gromadziński Leszek L Department of Internal Diseases, Gastroenterology and Hepatology, University Clinical Hospital in Olsztyn, ul. Warszawska 30, 10-082, Olsztyn, Poland, - - 2014
The increased value of the red cell distribution width (RDW) was reported to indicate poor prognosis in patients with chronic heart failure. We evaluated the value of the RDW in the diagnosis of left ventricular diastolic dysfunction (LVDD) in patients without diastolic heart failure among the chronic kidney disease (CKD) ...
Ohsawa Isao I Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, - - 2014
Background: Hereditary angioedema (HAE) is a rare but life-threatening condition that results from mutations in C1-inhibitor (C1-INH). Since distinguishing HAE from other causes of angioedema (AE) is a critical problem in emergencies, the objective of the present study was to clarify the differences between HAE and other forms of AE. ...
Aota Takumi T Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, - - 2014
Prevention of deep vein thrombosis (DVT) is important in patients undergoing major orthopedic surgery. Although the detection of an elevated D-dimer level is useful for predicting DVT, it is not efficacious in postoperative patients being treated with anti-Xa agents. The soluble platelet glycoprotein VI (sGPVI) level is a marker of ...
Miao Xutao X Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, - - 2014
Magnetic resonance imaging (MRI) and chemosensory event-related potentials (ERPs) are important methods to evaluate olfactory function, but there is lack of study to explore the application of MRI and chemosensory ERPs in the patients with traumatic anosmia. The data of 26 post-traumatic anosmic patients and 21 healthy controls were retrospectively ...
AlShardan Mohammad M MM King Fahad Medical City, King Saud Bin Abdulaziz University for Health Sciences, Faculty of Medicine, Department of Neurosurgery , Riyadh , Kingdom of Saudi - - 2014
Objective. To evaluate potential risk factors that can predict the development of hydrocephalus (HCP) in adult patients with intraventricular hemorrhage (IVH). Methods. Retrospective analysis of all adult patients presented to King Fahad Medical City between 2004 and 2011 with intraventricular hemorrhage to evaluate different variables and their association with HCP. ...
Slingerland Marije M Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands, - - 2014
To evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and varying degrees of hepatic function. Patients with advanced solid malignancies, acceptable bone marrow and renal function, and normal or impaired hepatic function, per NCI-ODWG criteria, were eligible. Initially patients received a single oral dose ...
Schuetz Philipp - - 2014
Abstract Plasma proadrenomedullin (ProADM) is a blood biomarker that may aid in multidimensional risk assessment of patients with chronic obstructive pulmonary disease (COPD). Co-secreted 1:1 with adrenomedullin (ADM), ProADM is a less biologically active, more chemically stable surrogate for this pluripotent regulatory peptide, which due to biological and ex vivo ...
Ruperto M M Departamento de Nutrición Humana y Dietética, Facultad de Ciencias de la Salud, Universidad Alfonso X el Sabio, Madrid, - - 2014
Protein-energy wasting (PEW) is a highly prevalent condition in haemodialysis patients (HD). The potential usefulness of nutritional-inflammatory markers in the diagnosis of PEW in chronic kidney disease has not been established completely. We hypothesised that a combination of serum albumin, percentage of mid-arm muscle circumference and standard body weight comprises ...
Vanacker Peter P Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Department of Neurology, University Hospital Antwerp, Edegem, - - 2014
PRES is a reversible neurotoxic state presenting with headache, altered mental status, visual loss, and seizures. Delayed diagnosis can be avoided if radiological patterns could distinguish PRES from cerebral ischemia. Clinical and radiological data were collected on all hospitalized patients who had (1) discharge diagnosis of PRES and (2) acute ...
Ezzedine K K Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin and University of Bordeaux and Inserm U1035, Bordeaux, - - 2014
Hypochromic vitiligo is a rare entity that has only been reported twice under the term vitiligo minor with an absence of clear delineation. The aim of this study was to delineate hypochromic vitiligo through a case series of patients with typical bilateral hypopigmented lesions affecting the face and the trunk. ...
Ryzhikova Elena E Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, - - 2014
The key moment for efficiently and accurately diagnosing dementia occurs during the early stages. This is particularly true for Alzheimer's disease (AD). In this proof-of-concept study, we applied near infrared (NIR) Raman microspectroscopy of blood serum together with advanced multivariate statistics for the selective identification of AD. We analyzed data ...
Biancari Fausto F Department of Surgery, Oulu University Hospital, Oulu, Finland. Electronic address: - - 2014
To evaluate the performance of the EuroSCORE II (ESII) and the Society of Thoracic Surgeons (STS) scores in surgical (SAVR) or transcatheter aortic valve replacement (TAVR). Systematic review of the literature and meta-analysis. University hospitals. Studies reporting data on the performance of ESII and STS scores in patients undergoing SAVR ...
Cervellin Gianfranco G Emergency Department, Academic Hospital of Parma, Italy. Electronic address: - - 2014
Aim of this study was to assess the role of blood lactate levels at admission in carbon monoxide (CO)-poisoned patients for establishing severity of poisoning and short term prognosis. All cases of CO poisoning visited in the emergency department during the years 2012 and 2013 were retrieved from the hospital ...
Nashel Jennifer J Beth Israel Deaconess Hospital, Boston, MA, - - 2014
Eosinophilic fasciitis (EF) is a rare localized fibrosing disorder of the fascia whose diagnosis is often suspected based on clinical findings and laboratory values. These lab abnormalities can be transient in early disease and may not always be present. We have reviewed a case series of patients to assess the ...
Iorio Biagio Di - - 2014
Objectives: The aim of this study was to assess potential effects of hightone external muscle stimulation (HTEMS) on parameters of endothelial dysfunction (ED) in patients with acute kidney injury (AKI). Background: The bad outcome of AKI patients is markedly influenced by ED, microinflammation, oxidative stress and protein hypercatabolism. Recently, we ...
Uchiyama-Tanaka Yoko Y Yoko Clinic , Kitakyushu, Japan - - 2014
Abstract Background: Probiotics increase beneficial microbiota and improve chronic conditions, such as atopic diseases, irritable bowel disease, and obesity. However, because there are so many probiotics, it is unknown which probiotics might have more of an effect on intestinal microbiota. Objective: To understand how two different types of probiotics influence ...
Mathew Sharon S Department of Nephrology and Nutrition, Pondicherry Institute of Medical Sciences , Puducherry , India - - 2014
Abstract Hydration and nutritional status of end stage renal disease (ESRD) patients are linked to increased morbidity and mortality. Body composition monitoring (BCM) by multi-frequency bioimpedance spectroscopy (MFBS) is considered to be a superior modality of fluid assessment in chronic kidney disease (CKD) dialysis. We did a longitudinal prospective study ...
Chen Yufei Y Massachusetts General Hospital, GRB-425, 55 Fruit Street, Boston, MA, 02114, USA, - - 2014
Primary hyperparathyroidism (PHPT) in the setting of previous roux-en-Y gastric bypass (RYGBP) is not well described. The diagnosis can be difficult, as secondary hyperparathyroidism (SHPT) commonly occurs in patients after RYGBP due to calcium malabsorption and vitamin D deficiency. All patients from 2000 to 2012 who underwent cervical exploration for ...
He Bosheng B Department of radiology, the first affiliated hospital of Soochow University, Jiangsu 215006, - - 2014
Objective: To compare the diagnostic capabilities between capsule endoscopy (CE) and multislice computed tomography enterography (MSCTE) in combination with MSCT angiography (MSCTA) for assessment of obscure gastrointestinal bleeding (OGIB). Methods: A total of 127 patients with OGIB were studied in this study. Eighty-two patients (aged 42.7±19.1 years; 34 males) were ...
Uruha Akinori A Department of Clinical Development, Translational Medical Center, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan Department of Neuromuscular Research, National Institute of Neuroscience, NCNP, Tokyo, Japan Department of Education, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, - - 2014
In hereditary myopathy with early respiratory failure (HMERF), cytoplasmic bodies (CBs) are often localised in subsarcolemmal regions, with necklace-like alignment (necklace CBs), in muscle fibres although their sensitivity and specificity are unknown. To elucidate the diagnostic value of the necklace CBs in the pathological diagnosis of HMERF among myofibrillar myopathies ...
Garcia-Nuñez Marian M Fundació Parc Taulí, Sabadell/Badalona, Spain. CIBER de Enfermedades Respiratorias, CIBERES, Bunyola, Spain. Universitat Autonoma de Barcelona, Esfera UAB, Barcelona, Spain. Fundació Institut d'Investigació Germans Trias i Pujol, Badalona, Spain. - - 2014
Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based techniques only identify a part of the bacteria in mucosal surfaces. The aim of the study was to determine changes in the bronchial microbiome of COPD associated with the severity of the ...
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