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Results 201 - 250 of 2902
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Dushianthan Ahilanandan - - 2014
BackgroundAcute respiratory distress syndrome (ARDS) is a life-threatening critical illness, characterised by qualitative and quantitative surfactant compositional changes associated with premature airway collapse, gas-exchange abnormalities and acute hypoxic respiratory failure. The underlying mechanisms for this dysregulation in surfactant metabolisms are not fully explored. Lack of therapeutic benefits from clinical trials, ...
Matsumoto Hideyuki H Department of Neurology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan, - - 2014
The aim of this paper is to investigate cortical excitability in patients with end-stage renal disease receiving peritoneal dialysis (PD) without any symptoms suggestive of uremic encephalopathy. We performed transcranial magnetic stimulation for 52 PD patients and 28 normal subjects. We compared the active motor threshold (AMT), resting motor threshold ...
Yuan Shanshan S Department of Endocrinology, Peking University First Hospital, Beijing 100034, - - 2014
Objective: Sera of Hashimoto's thyroiditis (HT) patients are known to exhibit elevated levels of anti-thyroglobulin IgG (TgAb IgG). Therefore, TgAb IgG represents a hallmark of this debilitating autoimmune disease. The aim of our study was to investigate the differential expression of specific glycosylation patterns of TgAb IgG from HT patients ...
Notarnicola A A DIM-Rheumatology Unit, Medical School, University of Bari , - - 2014
Objectives: To assess the serum levels of interleukin (IL)-15 and IL-17 in patients with idiopathic inflammatory myopathies (IIM) and correlate them with levels of IL-1 receptor antagonist (IL-1ra), IL-6, IL-10, interferon (IFN)-γ, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α, and MIP-1β. Possible correlations with disease activity parameters were also ...
Oliver Nora - - 2014
Abstract Acute leukemia patients develop venous thrombosis (VT) related to central venous catheters (CVC). Anticoagulation (AC) in these patients who are thrombocytopenic and often coagulopathic is challenging. To evaluate safety and efficacy of AC in treating CVC-related VT, we retrospectively compared outcomes of acute leukemia patients who were treated or ...
Schievink Wouter I WI Departments of - - 2014
OBJECT Spontaneous intracranial hypotension is an increasingly recognized cause of headaches. Pituitary enlargement and brain sagging are common findings on MRI in patients with this disorder. The authors therefore investigated pituitary function in patients with spontaneous intracranial hypotension. METHODS Pituitary hormones were measured in a group of 42 consecutive patients ...
Zhang Ning N Department of Medical Psychology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, - - 2014
In addition to motor symptoms, patients with Parkinson's disease (PD) may experience non-motor symptoms (NMS), more often with more advanced disease stage. However, the clinical feature of the NMS and potential risk factors that affect NMS in idiopathic PD patients remain unclear. 493 PD patients diagnosed with PD via the ...
Lopes Agnaldo José AJ Laboratory of Respiratory Physiology, State University of Rio de Janeiro, Brazil Rehabilitation Sciences Master's Program, Augusto Motta University Center, Rio de Janeiro, Brazil - - 2014
Bronchiectasis develops along the natural course of several respiratory and systemic conditions and induces significant changes in the morphofunctional structure of airways. Our objective was to assess the impact of various causes of bronchiectasis on clinical data, pulmonary function tests, and high-resolution computed tomography (HRCT). The present report was a ...
Probasco William W Department of Foot and Ankle Surgery, Hospital for Special Surgery, New York, - - 2014
Patients with adult-acquired flatfoot deformity (AAFD) develop peritalar subluxation, which may stem from valgus inclination of the inferior surface of the talus. We hypothesized that patients with AAFD would have an increased valgus tilt of the subtalar joint in the coronal plane compared to controls when assessed with a novel ...
Kataoka Yuko Y Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, - - 2014
Central diabetes insipidus (CDI), which is characterized by polyuria and polydipsia, is caused by a deficiency of the antidiuretic hormone arginine vasopressin (AVP). While CDI is treated with desmopressin, an analogue of AVP, the intranasal formulation is inconvenient and CDI patients reportedly prefer the oral formulation to the intranasal one. ...
Al-Maramhy Hamdi H Hamdi Al-Maramhy, Samer Sawalhi, Department of Surgery, College of Medicine, Taibah University, Al-Madina 30001, Saudi - - 2014
To assess levels of serum resistin upon hospital admission as a predictor of acute pancreatitis (AP) severity. AP is both a common and serious disease, with severe cases resulting in a high mortality rate. Several predictive inflammatory markers have been used clinically to assess severity. This prospective study collected data ...
Hedenus Michael M Department of Internal Medicine, Sundsvall Hospital, 851 86, Sundsvall, Sweden, - - 2014
This randomized trial evaluated ferric carboxymaltose without erythropoiesis-stimulating agents (ESA) for correction of anemia in cancer patients with functional iron deficiency. Patients on treatment for indolent lymphoid malignancies, who had anemia [hemoglobin (Hb) 8.5-10.5 g/dL] and functional iron deficiency [transferrin saturation (TSAT) ≤20 %, ferritin >30 ng/mL (women) or >40 ng/mL (men)], were randomized ...
Fabiá Valls M J - - 2014
Diagnostic management of suspected pulmonary embolism (PE) in patients with a history of venous thromboembolism (VTE) is complicated due to persistent abnormal D-dimer levels, residual embolic obstruction and higher clinical prediction rule (CPR) scores. We aimed to evaluate the safety and efficiency of the standard diagnostic algorithm consisting of a ...
van de Veerdonk Mariëlle C - - 2014
Even after years of stable response to therapy, patients with idiopathic pulmonary arterial hypertension (IPAH) may show an unexpected clinical deterioration due to progressive right ventricular (RV) failure. Therefore, the aim of this study was to assess in five-year clinically stable patients with IPAH whether initial differences or subsequent changes ...
Bilgiç Ozlem O Department of Dermatology - - 2014
Abstract Background: Prior studies have demonstrated lower serum zinc levels in acne vulgaris (AV) patients compared with controls. However, no study has investigated the relationship between AV and erythrocyte zinc levels, which is a superior indicator of body zinc levels. Additionally, the potential influence of isotretinoin use on body zinc ...
Haase Daniel D Department of Computer Science, Friedrich Schiller University, Jena, - - 2014
Aim of the present observational single center study was to objectively assess facial function in patients with idiopathic facial palsy with a new computer-based system that automatically recognizes action units (AUs) defined by the Facial Action Coding System (FACS). Still photographs using posed facial expressions of 28 healthy subjects and ...
Sun Wenxue W Department of Nephrology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, - - 2014
The purpose of this study was to investigate the correlation of conjunctival and corneal calcification (CCC) with cardiovascular calcification in patients undergoing maintenance hemodialysis (MHD). A total of 122 patients undergoing MHD in our hospital were included in this study. Conjunctival and corneal calcification was examined by slit lamp and ...
Coutinho Jonathan M JM From the Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands (J.M.C., J.S.); Department of Neurology, Hospital Santa Maria, Lisboa, Portugal (P.C., J.M.F.); Department of Neurology, Instituto Nacional de Neurologia y Neurocirurgia, México City, México (F.B.); and Department of Neurology, Hôpital Lariboisière, Paris, France (M.-G.B.). - - 2014
Although headache is the most common symptom in cerebral venous thrombosis, 5% to 30% of patients do not report headache at baseline. Characteristics of these patients have not been investigated. In post hoc analysis of the International Study on Cerebral Vein and Dural Sinus Thrombosis study, patients who might not ...
Hannoush H H Cardiovascular and Pulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, - - 2014
Proteus syndrome (PS) is a rare, mosaic disorder with asymmetric and distorting overgrowth of the skeletal system, skin, and adipose tissues. Cardiac abnormalities are rare in this syndrome and only two prior cases have been reported. Many patients with PS followed at our institution underwent transthoracic echocardiograms for preoperative evaluation ...
Calcagno A A Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, - - 2014
In limited-resource settings monitoring antiretroviral treatment efficacy is restrained by the lack of access to technological equipment. Aim of the study was to assess the use of dried plasma (DPS) and blood spots (DBS) to facilitate ARV monitoring in remote settings where clinical monitoring is the primary strategy. A cross-sectional ...
Heble Daniel E DE Jr 1Department of Pharmacy, Children's Mercy Hospital, Kansas City, MO; 2Divison of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO; and 3University of Missouri-Kansas City School of Pharmacy, Kansas City, - - 2014
Metabolic alkalosis is a common acid-base disturbance occurring in critically ill pediatric patients. Acetazolamide and arginine hydrochloride are pharmacologic agents used at our institution for patients refractory to first-line therapy or those unable to tolerate fluid replacement. The objective of this retrospective review was to determine if a course of ...
Zhong H H Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, - - 2014
Allergen-specific immunotherapy (ASIT) is the main treatment for inducing long-term immunological and clinical tolerance in patients with IgE-mediated allergic diseases. Recent open-label and controlled studies on the efficacy of ASIT in patients with atopic dermatitis (AD) have provided promising results. However, data about possible relationship between the improvement of clinical ...
Spencer Hillard T HT Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Hunnewell 2, Boston, MA, 02115, USA, - - 2014
Variation in rib numbering has been noted in adolescent idiopathic scoliosis (AIS), but its effect on the reporting of fusion levels has not been studied. We hypothesized that vertebral numbering variations can lead to differing documentation of fusion levels. We examined the radiographs of 161 surgical AIS patients and 179 ...
Daniłowicz-Szymanowicz Ludmiła L Department of Cardiology and Electrotherapy, Medical University of Gdańsk. - - 2014
Patients with left ventricular ejection fraction (LVEF) ≤ 35% are eligible for implantable cardioverter-defibrillator (ICD) placement for the primary prevention of sudden cardiac death (SCD). This recommendation results in continuously growing waiting lists of patients who have been qualified for and are awaiting the procedure. Whiled reduced LVEF is a ...
Alawami M M Green Lane Cardiovascular services, Auckland City Hospital, Auckland, New - - 2014
Obesity is a risk factor for both Sleep Related Breathing Disorders (SRBD) including Obesity Hypoventilation Syndrome (OHS) and Cardio-Vascular Diseases (CVD). The development of CVD in patients with SRBD is usually attributed to the fact that most patients are obese in addition to conventional cardiovascular risk factors. A dataset of ...
He Wei W Department of Physical Medicine and Rehabilitation, The Affiliated Jiangyin People's Hospital of Southeast University Medical College, Wuxi, - - 2014
We conducted a meta-analysis of positron emission tomography (PET) findings in Alzheimer's disease (AD) and mild cognitive impairment (MCI) to clarify the changes underpinning these conditions. All studies that utilised the PET tracers Pittsburgh Compound-B (PIB) or 2-[18F]fluoro-2-deoxy-D-glucose (FDG) to investigate patients with MCI or AD, were considered for the ...
Domitrz Izabela I Department of Neurology, Medical University of Warsaw, Warsaw, - - 2014
A migraine is a common neurological disorder that often coexists with other illnesses including heart abnormalities, such as patent foramen ovale (PFO), atrial septal aneurysm (ASA), and mitral valve prolapse (MVP). The aim of our study was to evaluate the occurrence of some heart abnormalities in migraine patients by routine ...
Sundareswaran Shobha - - 2014
Objectives :  The aims of this study were to analyze the prevalence of sella turcica bridging and to measure the size of the sella turcica on profile cephalograms in a homogenous group of surgically repaired unilateral cleft lip and palate (UCLP) patients. Setting :  Tertiary care center. Design :  Retrospective ...
Richards Anthony A Sydney Gynaecology Oncology Group, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, - - 2014
To determine the effectiveness of vaginal estrogen cream to improve the rate of satisfactory colposcopy and subsequent smear result in patients in a hypoestrogenic state and an abnormal Papanicolaou smear. To delineate between abnormal smears secondary to atrophy and inflammation from preneoplastic change and suggest an effective treatment strategy to ...
Hsiang J C JC Middlemore Hospital, Counties Manukau District Health Board, Otahuhu, Auckland, New - - 2014
Liver cirrhosis is an important cause of morbidity and mortality, however little is known about its impact in New Zealand. We aim to determine the disease burden, epidemiology and outcomes of cirrhotic patients METHODS: A retrospective study of patients with cirrhosis who sought care at a sole public hospital in ...
Caviglia Gian Paolo GP Department of Medical Sciences, University of Turin , Turin , - - 2014
Abstract Background. The clinical pictures of functional gastrointestinal disorders and inflammatory diseases can be quite similar leading to inappropriate and expensive investigations. Objective. To investigate fecal calprotectin (FC) diagnostic performance in different gastrointestinal conditions. Material and methods. Stool specimens of 66 outpatients referred for colonoscopy were collected for further FC ...
Cioffi Giovanni G Department of Cardiology, Villa Bianca Hospital, Trento, - - 2014
Early detection of left ventricular (LV) systolic dysfunction is pivotal in the management of patients with aortic stenosis (AS). LV circumferential and/or longitudinal shortening may be impaired in these patients despite LV ejection fraction is preserved. We focused on prevalence and factors associated with combined impairment of circumferential and longitudinal ...
Hong Hong H Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio; Case Western Reserve University School of Medicine, Cleveland, - - 2014
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening diagnosis requiring prompt initiation of therapeutic plasma exchange (TPE). Measurement of immature platelet (PLT) fraction (%-IPF) differentiates PLT consumption or destruction from hypoproduction. Our study evaluated %-IPF changes over the course of TTP treated with TPE and as a measure of treatment efficacy. ...
Kim Do Hoon DH Departments of Gastroenterology, Asan Digestive Disease Research Institute, University of Ulsan College of Medicine, Asan Medical Center , Seoul , - - 2014
Abstract Objectives. Patients with head and neck squamous cell carcinoma (HNSCC) often develop second primary tumors in the upper aerodigestive tract. Early detection of synchronous esophageal squamous cell neoplasm (ESCN) is important because the prognosis of HNSCC can be affected by the statuses of second primary tumors. Methods. In a ...
Demir Abdurrahman A Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine , Istanbul , - - 2014
Abstract Objective. Familial Mediterranean fever (FMF) is the most common form of autoinflammatory diseases. We aimed to evaluate the small bowel mucosa by capsule endoscopy (CE) in FMF patients for investigation of other possible causes of abdominal pain. Material and methods. The study group consisted of 41 patients with FMF. ...
Bajuk Nataša Bedernjak NB Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, - - 2014
The impact of hyperthyroidism induced by Graves' disease (GD) on skin microcirculation has not been established. We aimed to assess vascular reactivity in hyperthyroid GD patients before and during treatment. Laser Doppler flux (LDF) was measured in 31 newly diagnosed hyperthyroid GD patients with an increased TSH receptor stimulating antibody ...
Heckman Michael G MG From the Section of Biostatistics (M.G.H., N.N.D.) and Departments of Neuroscience (A.I.S.-O., S.R., K.O., M.E.M., D.W.D., O.A.R.) and Neurology (S.F., W.P.C., R.J.U., Z.K.W.), Mayo Clinic, Jacksonville, FL; Department of Molecular Neuroscience (L.S., A.S., H.H.), Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Department of Medical Genetics (M.J.F.), University of British Columbia, Vancouver, Canada; Laboratory of Neurogenetics (A.B.S.), National Institute on Aging, Bethesda, MD; Institute of Genetic Medicine (P.F.C., M.J.K.), Newcastle University, Central Parkway, Newcastle upon Tyne; Neuropathology Unit (S.M.G.), Department of Medicine, Imperial College London; Queen Square Brain Bank for Neurological Disorders (J.L.H., K.A.), Department of Molecular Neuroscience, UCL Institute of Neurology, University College London; Clinical and Cognitive Sciences Research Group (D.M.A.M.), Institute of Brain, Behavior and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford; and MRC London Neurodegenerative Diseases Brain Bank (S.A.-S., C.T.), King's College London, UK. - - 2014
The aim of this study was to evaluate the association between common exonic variants in the leucine-rich repeat kinase 2 (LRRK2) gene and risk of multiple system atrophy (MSA). One series from the United States (92 patients with pathologically confirmed MSA, 416 controls) and a second series from the United ...
de Beer Marlijn M From the Department of Neurology (M.d.B.), Haga Hospital, The Hague; the Department of Pediatric Neurology (M.E.), Emma Children's Hospital, Amsterdam; the Department of Neurology (M.E., B.M.v.G.), Academic Medical Center, University of Amsterdam; and the Department of Neurology (B.M.v.G.), Medical Center Alkmaar, the Netherlands. - - 2014
To study the frequency of additional cerebral demyelination in Dutch patients with adrenomyeloneuropathy (AMN). Consecutive patients with AMN from the Dutch X-linked adrenoleukodystrophy cohort without cerebral demyelination on MRI at inclusion, seen between January 1, 1992, and January 1, 1999, were included. Primary endpoints were brain involvement, death, or the ...
Sauer Arnaud A Service d'Ophtalmologie, Centre Hospitalier Universitaire de Strasbourg, France. Institut de Parasitologie et de Pathologie Tropicale, EA 7292, Fédération de médecine Translationnelle, Université de Strasbourg, France. - - 2014
Uveitis is a potentially blinding inflammatory disease. 30-50% of uveitis cases are considered idiopathic. The present study sought to determine intraocular cytokine patterns in different etiological types of uveitis in order to better understand their immunological regulation and determine whether the cytokine pattern may be a useful diagnostic tool. From ...
Kakisaka Keisuke K Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, - - 2014
The optimal conditions for hepatocyte proliferation should be clarified in an attempt to improve the impaired liver regeneration observed in patients with acute liver failure (ALF). In order to evaluate the significance of the serum AFP level and PT-INR as possible biomarkers of the proliferation of liver stem/progenitor cells (LPCs) ...
Choi Young Sik YS Y Choi, Seoul, Korea, Republic - - 2014
The aim of this study was to compare intrafollicular biomarkers of thiol-redox system and chronic inflammation in infertile patients with and without endometriosis and examine correlations between biomarkers and IVF outcomes. Sixty-five patients receiving IVF were included: 31 patients with endometriosis vs. 34 patients without endometriosis. Follicular fluid (FF) was ...
Li Jin-Feng - - 2014
Multiple sclerosis (MS) is a complex disease of neurological disability, affecting more than 300 out of every one million people in the world. The purpose of the study was to evaluate the therapeutic effects of human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation in MS patients. Twenty-three patients were enrolled ...
Tsourdi Elena - - 2014
Alemtuzumab, a humanized monoclonal antibody against CD52, is effective in the treatment of early relapsing-remitting multiple sclerosis (MS). Common adverse effects include an acute-phase reaction, infections and autoimmune diseases, including thyroid disorders. Patients from two phase 3 trials (CARE MS 1 and 2, n=15) were studied in a clinical research ...
den Hoed M A H MA Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The - - 2014
Methotrexate(MTX) is an effective and toxic chemotherapeutic drug in the treatment of pediatric acute lymphoblastic leukemia(ALL). In this prospective study, we aimed to identify metabolic and genetic determinants of MTX toxicity. One hundred and thirty-four Dutch pediatric ALL patients were treated with four high infusions MTX (HD-MTX: 5 g m(-2)) every other ...
Arnaldi D D Clinical Neurology, Dept. of Neuroscience (DINOGMI), University of Genoa, IRCCS AOU SanMartino--IST, Genoa, Italy - - - 2014
Several non motor symptoms (NMS) can precede the onset of the classical motor Parkinson's Disease (PD) syndrome. The existence of pre--motor and even pre--clinical PD stages has been proposed but the best target population to be screened to disclose PD patients in a pre--clinical, thus asymptomatic, stage is still matter ...
Altunoğlu Alpaslan A Department of Nephrology, Ataturk Education and Research Hospital, Bilkent-Ankara, - - 2014
We aimed to investigate serum cystatin C (cysC) levels in primary Sjögren's syndrome (pSS) patients, and evaluate its correlation with renal involment. Eighty-six pSS patients and 65 age- and gender-matched healthy controls were enrolled into the study. Serum cysC, urea, serum creatinine (SCr), creatinine clearance (CrCl), glomerular filtration rates (GFR), ...
Romijn Marloes D M MD Department of Geriatric Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Geriatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The - - 2014
In dialysis-dependent and severe chronic kidney disease (CKD) patients, cognitive impairment is found in 16-29%. In community-dwelling population without dementia mixed results have been observed. We investigated the relationship between renal function and cognition in patients from a memory clinic. We performed a cross-sectional study of consecutive patients from a ...
Schewel Dimitry D Division of Cardiology, ASKLEPIOS Clinics St. Georg Hospital, Lohmühlenstr. 5, 20099, Hamburg, Germany, - - 2014
Transcatheter aortic valve implantation (TAVI) is a proven alternative to open heart surgery in elderly patients. Pulmonary hypertension (PH) is known as a significant risk factor in patients with severe aortic stenosis (AS) undergoing surgical aortic valve replacement. However, the prognostic impact of PH in high-risk patients undergoing TAVI is ...
Goulis Ioannis I Department of Internal Medicine, Αristotle University of Thessaloniki Medical School, Hippokration General Hospital, Thessaloniki, - - 2014
We assessed predictors of response in HBeAg-negative chronic hepatitis B patients treated with peginterferonalfa-2a in routine clinical practice. Ninety-five HBeAg-negative patients receivedpeginterferonalfa-2a for 48 weeks and were followed-up for 48 weeks post-treatment. Serum HBsAg and HBV DNA levels were monitored during and after therapy with valid commercial assays. Sustained response ...
Sueda Shozo S Department of Cardiology, Ehime Niihama Prefectural Hospital, Hongou 3 choume 1-1, Niihama City, Ehime Prefecture, 792-0042, Japan, - - 2014
In the clinical grounds, patients with ≥90 % luminal narrowing during acetylcholine (ACh) testing had variable response. We investigated ischemic findings and chest symptoms in patients with ≥90 % luminal narrowing when performing ACh tests, retrospectively. We performed 763 ACh tests over 13 years (2001-2013). We analyzed chest symptoms and positive ischemic ECG ...
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