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Results 201 - 250 of 2836
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Romijn Marloes D M MD Department of Geriatric Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Geriatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The - - 2014
In dialysis-dependent and severe chronic kidney disease (CKD) patients, cognitive impairment is found in 16-29%. In community-dwelling population without dementia mixed results have been observed. We investigated the relationship between renal function and cognition in patients from a memory clinic. We performed a cross-sectional study of consecutive patients from a ...
Schewel Dimitry D Division of Cardiology, ASKLEPIOS Clinics St. Georg Hospital, Lohmühlenstr. 5, 20099, Hamburg, Germany, - - 2014
Transcatheter aortic valve implantation (TAVI) is a proven alternative to open heart surgery in elderly patients. Pulmonary hypertension (PH) is known as a significant risk factor in patients with severe aortic stenosis (AS) undergoing surgical aortic valve replacement. However, the prognostic impact of PH in high-risk patients undergoing TAVI is ...
Goulis Ioannis I Department of Internal Medicine, Αristotle University of Thessaloniki Medical School, Hippokration General Hospital, Thessaloniki, - - 2014
We assessed predictors of response in HBeAg-negative chronic hepatitis B patients treated with peginterferonalfa-2a in routine clinical practice. Ninety-five HBeAg-negative patients receivedpeginterferonalfa-2a for 48 weeks and were followed-up for 48 weeks post-treatment. Serum HBsAg and HBV DNA levels were monitored during and after therapy with valid commercial assays. Sustained response ...
Sueda Shozo S Department of Cardiology, Ehime Niihama Prefectural Hospital, Hongou 3 choume 1-1, Niihama City, Ehime Prefecture, 792-0042, Japan, - - 2014
In the clinical grounds, patients with ≥90 % luminal narrowing during acetylcholine (ACh) testing had variable response. We investigated ischemic findings and chest symptoms in patients with ≥90 % luminal narrowing when performing ACh tests, retrospectively. We performed 763 ACh tests over 13 years (2001-2013). We analyzed chest symptoms and positive ischemic ECG ...
AlSaleem Alhanouf A Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Po Box 3354, Riyadh, 11211, Saudi - - 2014
To assess serum 25-hydroxyvitamin D (25-OH vitamin D) status in Saudi children with systemic lupus erythematosus (SLE) and determined its association with clinical, laboratory variables and disease activity. This cross-sectional study comprised children with SLE who are followed at Pediatric Lupus Clinic. All patients reviewed for demographic data, age of ...
Siwiec R M RM Division of Gastroenterology & Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, - - 2014
The insula plays a significant role in the interoceptive processing of visceral stimuli. We have previously shown that gastroesophageal reflux disease (GERD) patients have increased insular cortex activity during esophageal stimulation, suggesting a sensitized esophago-cortical neuraxis. However, information regarding the functional connectivity (FC) of the insula during visceral stimulation is ...
Hegele Axel - - 2014
The causality of overactive bladder syndrome (OAB) is still not fully understood. Several studies indicate a significant increase of prostaglandin E2 (PGE2) in patients with OAB. However, in order to clarify whether these compounds can help to objectify the clinical diagnosis, further studies are needed. This prospective study aims to ...
Cho Shih-Feng - - 2014
The pathogenesis of multiple myeloma involves complex genetic and epigenetic events. This study aimed to investigate the role and clinical relevance of the long non-coding RNA (lncRNA), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in multiple myeloma. Bone marrow mononuclear cells were collected for analysis. The samples of multiple myeloma were ...
Torp-Pedersen S Ren SR The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Frederiksberg, Denmark; Deparment of Diagnostics, Radiology Section, Copenhagen University Hospital at Glostrup, - - 2014
Objectives: To determine how settings for power and color Doppler sensitivity varies on different high and intermediate range ultrasound (US) machines and to evaluate the impact of these changes on Doppler scoring of inflammatory joints Methods: Six different types of ultrasound machine were used. On each machine, the factory setting ...
Ward Michael M MM Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of - - 2014
Objective: The patient global assessment (PGA) is intended to provide an integrated summary of all symptoms of arthritis, but it is not clear which disease features most impact patients' assessments of changes in their overall status. We investigated what aspects of rheumatoid arthritis (RA) activity correlated best with prospectively measured ...
Akyuz Sukru S Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, - - 2014
Background: Efficacy of intravenous (IV) volume expansion in preventing contrast-induced acute kidney injury (CI-AKI) is well known. However, the role of oral hydration has not been well established. The aim of this work was to evaluate the efficacy of oral hydration in preventing CI-AKI. Methods: We prospectively randomized 225 patients ...
Andonegui Graciela G Department of Critical Care Medicine, Faculty of Medicine, University of Calgary Health Research Innovation Center, Calgary, Alberta, Canada Immunology Research Group, Faculty of Medicine, University of Calgary Health Research Innovation Center, Calgary, Alberta, - - 2014
Insulin-Like Growth Factor I (IGF-I) has been identified in the lungs of individuals with fibrotic lung diseases. In a previous retrospective study, we showed enhanced IGF-I immunoreactivity in individuals with fibroproliferative acute respiratory distress syndrome (FP-ARDS), but we were unable to determine if this correlation was causative. This study was ...
Bernardo Ana Paula AP Nephrology Department, Santo António Hospital, Oporto Hospital Center, Oporto, Portugal; UMIB/ICBAS/Porto University, Oporto, - - 2014
Adipokines impact on clinical outcomes is not adequately addressed in peritoneal dialysis (PD). We investigated the impact of leptin/adiponectin ratio (L/A) as a predictor of cardiovascular events (CVE) in PD, taking into consideration patient's body composition and the potential role of glucose load. We prospectively followed 66 prevalent PD patients ...
Neve Polimeno Maria M Oncological Immunology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale"-IRCCS-ITALIA, Naples, - - 2014
Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expression was analyzed by immunohistochemistry in 86 ...
Nielsen Anders K AK Department of Paediatrics A, Aarhus University Hospital , Aarhus , Denmark - - 2014
Abstract Background: Ophthalmologic studies of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) have focused mainly on retinal involvement, and so far no anterior segment abnormalities have been described. In the present study, we report the findings of pre-senile cataract in five patients with JNCL. Material and Methods: Our sample consisted of 35 ...
Zittermann Armin A Clinic for Thoracic and Cardiovascular Surgery - - 2014
Context: Several cohort studies have reported U-shaped or inverse J-shaped associations between circulating 25-hydroxyvitamin D [25(OH)D] and clinical outcomes. Objective: We aimed to investigate in cardiac surgical patients the association of preoperative 25OHD and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] levels with the risk of major cardiac and cerebrovascular events (MACCE). Design: Prospective ...
Belinchón I I Dpto. de Dermatología, Hospital General de Alicante, - - 2014
Abstract Background: Increasing evidence indicates a relationship between psoriasis and metabolic syndrome (MS). We evaluated the prevalence of MS in patients receiving systemic treatment for psoriasis in Spain, and its relationship to cardiovascular disease (CVD). Methods: This cross-sectional, multicenter, noninterventional study enrolled 368 patients with moderate-to-severe psoriasis requiring systemic treatment. ...
Slaets Sylvie S Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, - - 2014
Iodine-123 metaiodobenzylguanidine (MIBG) cardiac scintigraphy has shown the potential to discriminate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). However, these studies did not reflect clinical practice, as patients with ischemic heart disease, heart failure, diabetes mellitus, arterial hypertension, and hyperlipidemia and patients treated with antidepressants like trazodone were ...
Jung Jae Hoon JH *Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul; and †Department of Otolaryngology, Jeju National University, Jeju, Republic of - - 2014
We evaluated vestibular function test results in vestibular migraine (VM) patients, including caloric, vestibular evoked myogenic potential (VEMP), and dynamic posturography measurements and assessed their relationship with treatment responses. Retrospective case series review. Tertiary referral center. We investigated a cohort of 80 VM patients who had suffered recurrent vertigo attacks ...
Degraeuwe Pieter L J PL *Department of Paediatrics, Maastricht University Medical Centre, Maastricht, The Netherlands †Department of Paediatrics, Tampere University Hospital, Tampere, Finland ‡Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University of Naples "Federico II", Naples, Italy §Paediatric Gastroenterology, Sydney Children's Hospital, Randwick, Australia; and University of Otago (Christchurch), Christchurch, New Zealand ||Hepathology, Gastroenterology and Nutrition Unit, Bambino Gesù Children's Hospital, Rome, Italy ¶Dept. of Paediatrics, Centre for Clinical Research, Västmanlands Hospital, Västerås, Karolinska Institutet, Stockholm, Sweden #Department of Paediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh, and Child Life and Health, University of Edinburgh, UK **Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland ††Department of Paediatrics, University Hospital Antwerp, Edegem, Belgium ‡‡Department of Paediatric Gastroenterology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands §§Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, The - - 2014
The diagnostic accuracy of faecal calprotectin (FC) concentration for paediatric inflammatory bowel disease (IBD) is well described at the population level, but not at the individual level. We reassessed the diagnostic accuracy of FC in children with suspected IBD and developed an individual risk prediction rule using individual patient data. ...
Harel Stephanie S Département d'Immuno-Hématologie, Hôpital Saint-Louis, Paris, - - 2014
This retrospective analysis was conducted in 64 patients diagnosed with type I cryoglobulinaemia (CG) followed at two French centres. Median follow-up was 6·75 years. CG was IgG in 60% and IgM in 40% of all cases and was asymptomatic in 16 patients (25%). Cold-triggered ischaemic skin manifestations were observed in 33 ...
Huang Maotao M Department of Gastroenterology and Endocrinology, The 452(nd) Hospital of PLA, Chengdu, China. Electronic address: - - 2014
Currently, there is no treatment for decompensated liver cirrhosis except for liver transplantation. The safety and effect on liver function of a transjugular intrahepatic portosystemic shunt (TIPS) with and without autologous bone marrow cell (BMC) infusion in patients with decompensated liver cirrhosis were determined. Ten patients who were diagnosed with ...
Signoretti Marianna M Digestive and Liver Disease Unit, S. Andrea Hospital, University "Sapienza," Rome, - - 2014
To assess the prevalence of small intestinal bacterial overgrowth (SIBO) in chronic pancreatitis (CP), and analyze factors related with SIBO in CP. SIBO is to be considered a factor that worsens symptoms and nutritional status in patients with CP. However, the few studies evaluating the rate of SIBO in CP ...
Zhang Ni N Department of Hematology, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. - - 2014
The aim of the present study was to investigate the expression and effect of progranulin (PGRN) in patients with primary Sjögren's syndrome (pSS). In total, 26 newly diagnosed pSS patients and 26 healthy subjects were enrolled in this study. The serum levels of PGRN and the inflammatory factor, interleukin-6 (IL-6), ...
Stolpman David R DR *Department of Gastroenterology, Park Nicollet Clinic †Park Nicollet Institute, St Louis Park ‡Department of Internal Medicine, Division of Gastroenterology, University of Minnesota Medical School, Minneapolis, - - 2014
To achieve an excellent bowel preparation, it is routine to require a clear liquid diet on the day before the procedure. Unfortunately, this dietary modification may be poorly tolerated. We examine whether a change in precolonoscopy dietary restriction can lead to better patient tolerance without compromising examination quality. This is ...
Bagattini Brunella B Endocrinology SectionDepartment of Clinical and Experimental Medicine, University Hospital of Pisa, University of Pisa, Via Paradisa 2, Cisanello, Pisa 56124, - - 2014
Levothyroxine (l-T4) is commonly employed to correct hormone deficiency in children with congenital hypothyroidism (CH) and in adult patients with iatrogenic hypothyroidism. To compare the daily weight-based dosage of the replacement therapy with l-T4 in athyreotic adult patients affected by CH and adult patients with thyroid nodular or cancer diseases ...
Zulueta-Santos Cristina C Department of Otorhinolaryngology, Clínica Universidad de Navarra, University Hospital and Medical School, University of Navarra , Pamplona, Navarra , - - 2014
Abstract Conclusion: The distribution of abnormal results is not uniform between different canals in each patient; the most frequent gain reduction is obtained for the posterior canal. Gain reduction reflects the disease duration and amount of hearing loss. To test the hypothesis that the vestibulo-ocular reflex (VOR) evoked after stimulation ...
Ornek Ahmet A Department of Internal Medicine I, Marienhospital Herne, Medical Center of Ruhr University Bochum, Herne, Germany (A.Ö., M.K., B.F.H., N.P., A.G.); Institute for Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Bergmannsheil, Ruhr University Bochum, Bochum, Germany (A.Ö.); and Department of Internal Medicine I, St Josef-Hospital, Medical Center of Ruhr University Bochum, Bochum, Germany (R.S., W.S., - - 2014
Familial Mediterranean fever (FMF) can be associated with splenomegaly. Prospective quantitative data are lacking. We performed a sonographic assessment of spleen size in patients with FMF and healthy control participants to assess its diagnostic value. Patients with FMF according to the criteria of Livneh et al (Arthritis Rheum 1997; 40:1879-1885) ...
Tufan Zeliha Kocak ZK Department of Infectious Diseases and Clinical Microbiology, Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Ankara, Turkey (Z.K.T.); and Departments of Radiology (H.Y., M.K., P.K.) and Infectious Diseases and Clinical Microbiology (C.B., G.C., C.A.H., S.K., A.P.D.), Ankara Training and Research Hospital, Ankara, Turkey. - - 2014
Crimean-Congo hemorrhagic fever (CCHF) has been endemic in Turkey since 2002. Some radiologic findings are considered common by clinicians and radiologists. In this regard, we aimed to assess the sonographic findings in patents with CCHF in a pilot study to obtain basic knowledge for planning further controlled studies. An observational ...
Abe Masahiro M Department of Infectious Diseases, Toranomon Hospital, Tokyo, - - 2014
The aim of this study was to evaluate the usefulness of serum (1,3)-beta-D-glucan (BDG) for earlier detection of breakthrough candidemia. We reviewed the medical records of patients with candidemia from January 2008 to March 2013. Serum BDG was measured by Wako turbidimetric assay. During the study period, a total of ...
Morad Abass Abdelfatah - - 2014
Introduction. Patients with end-stage renal disease are known to suffer from chronic inflammation as the result of an ongoing subacute cytokine induction, which may contribute considerably to dialysis-related long-term morbidity and mortality. In order to assess the inflammatory risk associated with online hemodiafiltration compared to conventional hemodialysis, we compared the ...
Yildiz Abdulmecit A Department of Nephrology, Cekirge State Hospital, Osmangazi, Bursa, Turkey. - - 2014
Introduction. Recent studies report reduced vascular compliance and elevated levels of fibroblast growth factor 23 (FGF23) in patients with autosomal dominant polycystic kidney disease (ADPKD) and preserved kidney function. In the present study, we investigated the relationship between vascular compliance and FGF23 in patients in early phases of ADPKD. Materials ...
Tezer Hasan H From the *Gazi University School of Medicine, Department of Pediatric Infectious Diseases; †Ankara Hematology and Oncology Research Hospital Pediatric Infectious Diseases Unit; and ‡Intergen Genetics Center, Ankara, - - 2014
Crimean-Congo hemorrhagic fever is a zoonotic disease that can be a severe illness in humans. We investigated concentrations of interleukin (IL)-6, tumor necrosis factor-α and IL-10 in serum samples obtained from 25 pediatric Crimean-Congo hemorrhagic fever cases and 35 control children with no signs of infection. Lower cytokine values in ...
Oda Tsuneyuki - - 2014
Pleuroparenchymal fibroelastosis (PPFE) is a rare form of interstitial pneumonia and sometimes coexists with a histologic usual interstitial pneumonia (UIP) pattern. This study aimed to describe the distinct clinical features of PPFE with UIP pattern compared with idiopathic pulmonary fibrosis (IPF). We conducted a retrospective review of the medical records ...
Koh Han-Ra HR Department of Internal Medicine, Chonnam National University Medical School, Gwangju, - - 2014
Endoscopic retrograde cholangiopancreatography (ERCP) is considered a high-risk procedure in patients with previous acute coronary syndrome (ACS); however, clinical studies are rare in the literature. The aim of this study was to investigate the safety and efficacy of ERCP in patients with previous ACS. We retrospectively reviewed the medical records ...
Saura D D Unidad de Imagen Cardiaca, Servicio Murciano de Salud, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB Arrixaca, Murcia, - - 2014
Systolic aortic regurgitation (SAR) is a curious phenomenon that has been found to be associated with heart failure (HF). We aimed to determine de diagnostic value of SAR as a black box predictive tool in patients with suspected HF admitted to hospital with dyspnea as leading symptom. Cross-sectional study including ...
Montilla Carlos C From the Services of Rheumatology; Anesthesiology, Hospital Clínico Universitario de Salamanca, Salamanca; Rheumatology, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba, Córdoba; Rheumatology, Hospital Universitario Central de Asturias, Oviedo; Rheumatology, Hospital Clinic de Barcelona; Rheumatology, Hospital de Bellvitge, L'Hospitalet de Llobregat; Rheumatology, Hospital Parc Taulí, Sabadell, Barcelona; Rheumatology, Hospital Fundación de Alcorcón; Rheumatology, Hospital Puerta de Hierro, Madrid, Spain. C. Montilla, MD, PhD; I. Calero-Paniagua, MD, Rheumatology; A. Díaz-Alvarez, MD, PhD, Anesthesiology, Hospital Clínico Universitario de Salamanca; E. Collantes-Estevez, MD, PhD; P. Font, MD, PhD, Rheumatology, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba; R. Almodovar, MD, PhD; P. Zarco, MD, PhD, Rheumatology, Hospital Fundación de Alcorcón; R. Queiro-Silva, MD, PhD, Rheumatology, Hospital Universitario Central de Asturias; J.D. Cañete, MD, PhD, Rheumatology, Hospital Clinic de Barcelona; X. Juanola, MD, PhD, Rheumatology, Hospital de Bellvitge, L'Hospitalet de Llobregat; J. Mulero, MD, PhD; E. de Miguel, MD, PhD, Rheumatology, Hospital Puerta de Hierro; J. Gratacós, MD, PhD, Rheumatology, Hospital Parc Taulí. Address correspondence to Dr. C. Montilla, Service of Rheumatology, Hospital Clínico Universitario de Salamanca, Paseo San Vicente 58-182, E-38007 Salamanca, Spain. E-mail: montillamorales.carlos@gmail.com. Accepted for publication August 27, - - 2014
To evaluate clinical factors associated with the absence of radiographic progression in patients with spondylitis. The cross-sectional study included 672 patients. All patients presented a disease evolution of more than 15 years. Patients were classified as with radiographic spinal involvement versus without radiographic spinal involvement. We included clinical variables potentially ...
López-Mejias Raquel R From the Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Department of Internal Medicine, Hospital Universitario Marques de Valdecilla, and the Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and Fundación Instituto de Investigación Marqués de Valdecilla, and Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), and CIBER Epidemiología y Salud Pública (CIBERESP), Santander; the Rheumatology Division, Hospital Universitario de Canarias, Tenerife; the Cardiology Division, Hospital Lucus Augusti, Lugo, Spain; the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by grants from "Fondo de Investigaciones Sanitarias" PI06/0024, PS09/00748, and PI12/00060 (Spain). This work was also partially supported by RETICS Program, RD08/0075, and RD12/0009/0013 (RIER) from "Instituto de Salud Carlos III" (ISCIII; Spain). Research performed by Dr. P.H. Dessein was supported by the South African Medical Research Council (grant number MRC2008_DES) and the National Research Foundation. P.H. Dessein and M.A. Gonzalez-Gay share senior authorship. R. López-Mejias, PhD; B. Ubilla, BSc; F. Genre, PhD; A. Corrales, MD, PhD; R. Blanco, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IFIMAV; J.L. Hernández, MD, PhD, Department of Internal Medicine, Hospital Universitario Marques de Valdecilla, University of Cantabria, RETICEF, IFIMAV; I. Ferraz-Amaro, MD, Rheumatology Division, Hospital Universitario de Canarias; L. Tsang; P.H. Dessein, MD, FCP(SA), FRCP(UK), PhD, Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; J. Llorca, MD, PhD, Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBERESP, IFIMAV; C. Gonzalez-Juanatey, MD, PhD, Cardiology Division, Hospital Lucus Augusti; M.A. Gonzalez-Gay, MD, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IFIMAV, and the Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand. Address correspondence to Dr. P.H. Dessein, P.O. Box 1012, Melville 2109, Johannesburg, South Africa. E-mail: dessein@telkomsa.net. Accepted for publication September 17, - - 2014
We determined whether osteoprotegerin (OPG) concentrations are associated with established cardiovascular disease (CVD) among patients with rheumatoid arthritis (RA). OPG concentrations were measured by ELISA in 151 patients with RA (54 with CVD) and 62 age-matched control subjects without CVD. Established CVD was composed of documented ischemic heart disease, cerebrovascular ...
Dyson Jessica K JK The Liver Unit, Freeman Hospital, Newcastle Upon Tyne, NE7 7DN, United - - 2014
Patients with primary sclerosing cholangitis (PSC) frequently highlight the impact of fatigue on their life quality. The study aims were to evaluate fatigue and its associations in PSC and investigate whether overt autonomic dysfunction contributes to the expression of fatigue. All PSC patients under active follow-up at a regional liver ...
Fossat Chantal C Hematology Laboratory, Hôpital de la Timone, Marseille, - - 2014
Minimal residual disease (MRD) assessment provides a powerful prognostic factor for therapeutic stratification in acute lymphoblastic leukemia (ALL). Multiparameter flow cytometry (MFC) has the potential for a rapid and sensitive identification of high risk patients. Our group has previously published that MRD levels analyzed by clone specific Ig/TcR-QPCR and MFC ...
Kuzmina Zoya Z Graft-versus-Host and Autoimmunity Unit, Experimental Transplantation and Immunology Branch, National Institutes of Health, National Cancer Institute NCI, Bethesda, MD; Internal medicine department, Evangelical - - 2014
There is an unmet need for identifying new clinical biomarkers in chronic Graft-versus-Host-disease (cGVHD) suitable for diagnosis and disease monitoring. Circulating autoantibodies represent an ongoing immune response and suggest a pathogenic role for B cells in cGVHD. Autoantibodies could be useful markers of cGVHD disease activity, severity or organ specificity; ...
Ge Yongpeng Y Department of Rheumatology, China-Japan Friendship Hospital, Yinghua East Road, Chaoyang District, 100029, Beijing, - - 2014
The purpose of this study is to review and summarize published information on the use, effectiveness, and adverse effects of cyclophosphamide (CYC) in the management of idiopathic inflammatory myopathies (IIM) and IIM-related interstitial lung disease (IIM-ILD). We performed a systematic search on various databases from May 1975 to May 2014 ...
Domsic Robyn T RT Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. - - 2014
To evaluate endothelial function and vascular stiffness in large, medium, small and microcirculatory blood vessels in very early diffuse systemic sclerosis (SSc). We studied consecutive early diffuse SSc patients, defined as <2 years from first SSc symptom who did not have a prior cardiovascular event. Age, gender and race-matched controls ...
Huang Jing J Department of Rheumatology, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No.1 shuaifuyuan, Beijing 100730, China. - - 2014
Pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, especially in systemic sclerosis (SSc). Since there was no published study regarding PAH in the Chinese SSc population, we aimed to describe a cohort to provide some data for early diagnosis. We evaluated 236 systemic sclerosis patients prospectively registered ...
Tauber Marie M Rheumatology A Department, Cochin Hospital, University Paris Descartes, Inserm U1016 and APHP, Paris, France. - - 2014
There is a paucity of data available on small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc). The objectives of the study were to estimate the prevalence of SIBO in SSc patients exhibiting intestinal symptoms and identify patients at risk of SIBO regarding clinical and biological presentations and gastrointestinal symptoms ...
Han Hyun Jeong HJ Department of Neurology, Myongji Hospital, Goyang, Republic of - - 2014
Background: The K variant of butyrylcholinesterase (BCHE-K) exhibits a reduced acetylcholine-hydrolyzing capacity; so the clinical response to rivastigmine may differ in Alzheimer's disease (AD) patients with the BCHE-K gene. Objective: To investigate the clinical response to rivastigmine transdermal patch monotherapy or memantine plus rivastigmine transdermal patch therapy in AD patients ...
Pathan Sameer A SA The Department of Emergency Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, - - 2014
There is little information available from the Middle Eastern region on adult patients presenting with first seizure. The objectives of this study were to describe epidemiological characteristics of patients presenting to the emergency department (ED) in Doha, Qatar, with first seizure and to determine the incidence of computed tomographic (CT) ...
Atteno Mariangela M Rheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, - - 2014
Clinical Development Phases I-III Regulatory, Quality, Manufacturing Postmarketing Phase IV Thalassemic trait (Thal) is associated with rheumatic disease, particularly a mild form of seronegative polyarthritis resembling rheumatoid arthritis (RA), but not with other rheumatic diseases. The aim of this study was to estimate the frequency of Thal in patients with ...
Gisondi Paolo P Department of Medicine, Section of Dermatology and Venereology, University of Verona, I-37126, Verona, - - 2014
Postmarketing Phase IV Psoriasis is frequently associated with obesity, which may favor the development of hyperuricemia. Hyperuricemia predisposes patients to gout arthritis and is an emerging cardiovascular risk factor. In this study, we investigated the prevalence of hyperuricemia and serum uric acid (SUA) levels in psoriatic patients. SUA was measured ...
Sanya E O EO Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, - - 2014
Patient's perception of seizure precipitant is crucial in epilepsy management, but it is often overlooked by physicians. This may be due to neglect and underestimation of its importance. This study looked at frequency and nature of self-perceived seizure precipitants among patients with epilepsy. A close-ended questionnaire-based study. Patients with active ...
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