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Lisman Ton T Surgical Research Laboratory and Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The - - 2014
Patients with chronic liver diseases may acquire substantial alterations in their hemostatic system when the disease progresses to fibrosis or cirrhosis[1]. Paradoxically, patients with cirrhosis show both hypo- and hypercoagulable features both from a clinical and laboratory perspective[2]. Clinically, the bleeding risk of patients with cirrhosis has long been recognized. ...
Cantó Ester - - 2014
BackgroundIn a previous proteomics study using pooled cerebrospinal fluid (CSF) samples, we proposed apolipoprotein AI, apolipoprotein AIV, vitronectin, plasminogen, semaphorin 7A, and ala-ß-his-dipeptidase as candidate biomarkers associated with the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndromes (CIS). Here, we aimed to validate these results ...
Defilippis Ersilia M EM Department of Gastroenterology and Hepatology, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY, - - 2014
Cerebral venous thrombosis (CVT) is a rare but devastating complication of inflammatory bowel disease (IBD) that is estimated to occur in 1.3-6.4% of patients. A retrospective chart review was performed from April 2009 through May 2014 to identify IBD patients who had CVT diagnosed during their lifetime. Six IBD patients ...
Kaderli Berkant B Department of Ophthalmology, Faculty of Medicine, Uludag University, Bursa, - - 2014
To investigate whether the Tei index, which is an indicator of global myocardial function and an independent predictor of cardiac death, is increased in patients with branch retinal vein occlusion (BRVO). The Tei index was used to evaluate myocardial performance, in addition to conventional echocardiographic evaluation of myocardial structural and ...
Martino Francesca F NEPHROLOGY, DIALYSIS AND KIDNEY TRANSPLANT, SAN BORTOLO HOSPITAL, VICENZA, Italy - - 2014
♦ Background: Peritoneal dialysis (PD) is frequently complicated by high rates of peritonitis, which result in hospitalization, technique failure, transfer to hemodialysis, and increased mortality. Early diagnosis, and identification of contributing factors are essential components to increasing effectiveness of care. In previous reports, neutrophil gelatinase-associated lipocalin (NGAL), a lipocalin which ...
Peng Fenfen F Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, - - 2014
♦ Objective: To explore the effect of glycated hemoglobin (HbA1c) and albumin-corrected glycated serum proteins (Alb-GSP) on the mortality of diabetic patients receiving continuous peritoneal dialysis (PD). ♦ Methods: In this single-center retrospective cohort study, incident diabetic PD patients from January 1, 2006, to December 31, 2010, were recruited, and ...
Wehrwein Erica A EA Department of Physiology, Michigan State University, East Lansing, MI, - - 2014
Background: Hyperoxia reduces hypoglycemia counterregulation in healthy adults. We hypothesized this effect is mediated by the carotid bodies and that: 1) hyperoxia would have no effect on hypoglycemia counterregulation in patients with bilateral carotid body resection, and 2) carotid body resected patients would exhibit an impaired counterregulatory response to hypoglycemia. ...
Yang Xiaobo X Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, - - 2014
Inflammatory myofibroblastic tumor of the liver (IMTL) is a very rare benign disease with a good prognosis. To determine the clinical, radiological, and pathological characteristics of IMTL. The diagnosis and treatment strategies were discussed. A total of eleven patients with pathologically confirmed IMTL receiving treatment over a 15-year period were ...
Toki Sayaka S Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, - - 2014
Autoimmune thyroid disorders (AITD) are characterized by the impairment of the thyroid gland as a result of systemic or organ-specific autoimmune disorders, and the presence of antithyroid autoantibodies, such as antithyroglobulin antibody (AbTg) and antithyroid peroxidase antibody (AbTPO). Several studies have reported the association of AITD with systemic sclerosis (SSc). ...
Park Jin-Sung JS Department of Neurology, Kyungpook National University School of Medicine, Daegu, - - 2014
Late-onset Pompe disease (LOPD) is an autosomal recessive disorder caused by deficiency of the enzyme acid glucosidase alfa (GAA). Recently, enzyme replacement therapy (ERT) using recombinant human GAA (rhGAA) became clinically available, and is expected to modify the clinical course in LOPD of various stages. In this study, we evaluated ...
Hanaoka Beatriz Y BY Department of Internal Medicine, Division of Rheumatology, College of Medicine, University of Kentucky, 138 Leader Avenue, Lexington, KY, 40506-9983, - - 2014
The goals of this study were to assess the predictive value of chart-abstracted American College of Rheumatology functional status (ACR-FS) with patient-reported ACR-FS and to relate it with measures of muscle function in a single-institution cohort of patients with idiopathic inflammatory myopathies (IIMs). Demographic and clinical data of 102 patients ...
Oliva A A Aix Marseille University, IP-TPT UMR MD3, Marseille, - - 2014
Immunoprecipitin detection (IPD) is the current reference confirmatory technique for anti-Aspergillus antibody detection; however, lack of standardisation is a critical drawback of this assay. In this study, we evaluated the performance of the Aspergillus Western Blot (Asp-WB) IgG kit (LDBio Diagnostics, Lyon, France), a recently commercialised immunoblot assay for the ...
Brill Livnat L Department of Neurology and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Medical Center Jerusalem, - - 2014
Screening of putative autoimmune targets in multiple sclerosis (MS) revealed a proportion of patients carrying antibodies (Abs) against KIR4.1, a potassium channel that shares functional properties with AQP4. Both are localized at the perivascular astrocytic processes. To measure anti-KIR4.1 Abs in the serum of MS and neuromyelitis optica (NMO) patients, ...
Baranzini Sergio E SE Department of Neurology, University of California, San Francisco (UCSF), San Francisco, USA/ Equal contribution - - 2014
Interferon beta (IFNb) reduces relapse frequency and disability progression in patients with multiple sclerosis (MS). Early identification of prognostic biomarkers of IFNb-treated patients will allow more effective management of MS. The IMPROVE study evaluated subcutaneous IFNb versus placebo in 180 patients with relapsing-remitting MS. Magnetic resonance imaging scans, clinical assessments, ...
Zhang Alan L AL Department of Orthopaedic Surgery, University of California - San Francisco, San Francisco, - - 2014
Retrospective Cohort Study. To investigate the relationship between cervical spine (C-spine) and rotator cuff (RTC) pathology. Cervical spine and rotator cuff pathology cause significant shoulder pain in isolation and in tandem but there is limited information about the relationship between these two entities. Patients with a diagnosis of C-spine and/or ...
Takahashi H H Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, - - 2014
The objective of this paper is to identify predictors for the response to treatment of acute lupus hemophagocytic syndrome (ALHS). We reviewed seven cases with ALHS admitted to our hospital and published ALHS cases identified in the 2001-2014 Medline database, and then conducted univariate and multivariate analyses to identify predictors ...
Koo B S BS Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, - - 2014
To compare the clinical characteristics of lupus enteritis (LE) and non-enteric lupus (non-LE) patients and identify predictors of LE recurrence. We retrospectively reviewed the medical records of 62 systemic lupus erythematosus (SLE) patients in a tertiary hospital who experienced enteric symptoms and underwent abdominal computed tomography scanning between January 1997 ...
Shikata Toshiyuki T Department of Pharmacy, Hyogo College of Medicine - - 2014
Background:Proton pump inhibitors (PPI) are frequently prescribed in combination with aspirin for preventing peptic ulcer in patients with atherosclerotic diseases. In contrast, long-term use of PPI has been suggested to be associated with iron or vitamin B12deficiency. The effect of PPI on hemoglobin (Hb) concentration, however, has not been clarified ...
Bestawros Michael M Autonomic Dysfunction Center & Department of Medicine, Vanderbilt University School of Medicine, Nashville, - - 2014
-Ictal asystole is a rare, serious, and often treatable cause of syncope. There are currently limited data to guide management. Characterization of ictal syncope predictors may aid in the selection of high-risk patients for treatments such as pacemakers. -We searched our epilepsy monitoring unit database from October 2003 through July ...
Ayan Arif A Ataturk University, Faculty of Medicine, Department of Nuclear Medicine, 25240 Erzurum, Turkey. - - 2014
The aim of this study was to evaluate the possible favorable effect of desloratadine-montelukast combination on salivary glands (SG) function in patients with allergic rhinitis (AR) using SG scintigraphy. The study population consisted of 64 patients with AR and 28 healthy controls: 14 males and 14 females, with mean age ...
Jo Si Young SY Department of Otolaryngology, Chonnam National University Medical School, Gwangju, Republic of - - 2014
Aim: To describe our surgical technique and compare the results of obliteration materials. Patients and Methods: Fifty patients over a 7-year period were evaluated retrospectively. Out of these 50 consecutive patients, 29 had recurrent chronic otitis media (COM) with or without cholesteatoma and 21 patients had old open cavities. Efficacy ...
Koros Christos C 1st Department of Neurology, Aeginition Hospital, University of Athens, Athens, - - 2014
Aim: The pathogenic role of Herpes Simplex Virus (HSV) 1 and 2 in Multiple Sclerosis (MS) still remains obscure. The aim of our study was the assessment of HSV1 and 2 DNA prevalence in the cerebrospinal fluid (CSF) of MS patients compared to patients with other neurological disorders (OND). Materials ...
Jefferies Helen J HJ Department of Renal Medicine, Royal Derby Hospital, Derby, - - 2014
Background/Aims: Endotoxaemia, a driver of systemic inflammation, appears to be driven by dialysis-induced circulatory stress in haemodialysis (HD) patients. More frequent HD regimens are associated with lower ultrafiltration requirements, improved haemodynamic stability and lower systemic inflammation. This study investigated the hypothesis that more frequently dialysed patients, with reduced exposure to ...
Goh M Y MY 1] Department of Clinical Pharmacology, Austin Hospital, Heidelberg, Victoria, Australia [2] University of Melbourne, Parkville, Victoria, Australia [3] The Spinal Research Institute, Heidelberg, Victoria, - - 2014
Study design:Retrospective study.Objectives:To quantify diurnal blood pressure (BP) patterns and nocturnal hypertension and to measure diurnal urine production in spinal cord injury (SCI) patients with clinically significant disorders of BP control.Setting:A specialist state-based spinal cord service in Victoria, Australia.Methods:Medical records of patients with traumatic SCI who were referred to a ...
Zilberberg Eran E Department of Obstetrics and Gynecology, Chaim Sheba Medical Center - Tel Hashomer , Ramat Gan , Israel - - 2014
Abstract Objective: Human chorionic gonadotropin (hCG) is usually used at the end of controlled ovarian hyperstimulation (COH), as a surrogate LH surge, to induce final oocyte maturation and resumption of meiosis. Recently, the co-administration of GnRH agonist and hCG for final oocyte maturation - 40 and 34 h prior to OPU, ...
Siniscalchi Antonio A Department of Neurology, "Annunziata" Hospital, Cosenza, - - 2014
Sudden unexplained/unexpected death (SUDEP) is related to high mortality in patients with epilepsy. The prolongation of QT interval, involved in cardiac arrhythmia-related SUDEP, may be precipitated by antiepileptic dru gs (AEDs). In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures. ...
Gorek Dilektasli Asli A Department of Pulmonary Diseases, Faculty of Medicine, Baskent University , Ankara , Turkey - - 2014
Abstract Diagnosis of latent Mycobacterium tuberculosis infection (LTBI) by the tuberculin skin test (TST) is hampered due to anergy and impaired sensitivity in chronic renal failure (CRF) patients. We aimed to compare the diagnostic performance of the TST with that of interferon-gamma immunospot (T-SPOT.TB®) assay in diagnosing LTBI in CRF ...
Krogias Christos C Department of Neurology, Ruhr University Bochum St. Josef-Hospital, Gudrunstr. 56, 44791, Bochum, Germany, - - 2014
Myotonic dystrophies (DMs) are clinically similar but distinct multisystemic diseases related to different repeat expansion mutations. CNS involvement is one important aspect of both, myotonic dystrophy type 1 and type 2 (DM1, DM2). Transcran ial sonography (TCS) has become a reliable diagnostic tool in the evaluation of several CNS disorders. ...
Stiver Corey C The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, - - 2014
Diastolic dyssynchrony is increasingly being recognized as another marker for possible adverse cardiac events. Minimal data exist in hypoplastic left heart syndrome (HLHS) patients. The goal of this study was to determine if there were differences in diastolic dyssynchrony in patients with HLHS vs. control patients. Tissue Doppler imaging (TDI) ...
Lee J J Department of Internal Medicine, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-Gu, Daegu, 700-842, Republic of - - 2014
Tuberculous pleural effusion (TPE) is characterized by lymphocytic predominance and high adenosine deaminase (ADA) levels. However, TPEs sometimes present non-lymphocytic predominance, and parapneumonic effusion (PPE) often exceeds the cutoff value of ADA for TPE. Thus, the differential diagnosis of cases with pleural fluid (PF) showing non-lymphocytic predominance and high ADA ...
Hua Jing J Key laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive - - 2014
We aimed to evaluate the efficacy of liver stiffness measurement (LSM) in predicting the presence and severity of esophgeal varices (EV) and its association with liver function in patients with liver cirrhosis. Medical records of 90 cirrhotic patients who underwent LSM by transient elastography were retrospectively reviewed. The relationship between ...
Jun Chung Hwan CH Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, - - 2014
To evaluate risk factors and clinical outcomes for spontaneous rupture of pyogenic liver abscess. A total of 602 patients diagnosed with pyogenic liver abscess between January 2004 and July 2013 were retrospectively analyzed. Among the 602 patients, 23 patients experienced spontaneous rupture of pyogenic liver abscess. The prevalence of spontaneous ...
Correa-Gallego Camilo C Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2014
Low central venous pressure (LCVP)-assisted hepatectomy is associated with decreased blood loss and lower transfusion rates. Concerns about its impact on renal function have prevented widespread application. This study was conducted to review the dynamics of renal function after LCVP-assisted hepatectomy. A retrospective analysis of a prospective surgical database was ...
Tilan Jason U JU Department of Nursing, School of Nursing and Health Studies, Georgetown University, Washington, District of Columbia; Department of Human Science, School of Nursing and Health Studies, Georgetown University, Washington, District of - - 2014
Ewing sarcoma (ES) is driven by fusion of the Ewing sarcoma breakpoint region 1 gene (EWSR1) with an E26 transformation-specific (ETS) transcription factor (EWS-ETS), most often the Friend leukemia integration 1 transcription factor (FLI1). Neuropeptide Y (NPY) is an EWS-FLI1 transcriptional target; it is highly expressed in ES and exerts ...
Lim Hyeong-Seok HS Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, Ulsan University College of Medicine, Republic of - - 2014
The objective of current study is to assess the relationship between characteristics of patients with acute ischemic stroke and clinical recurrences to identify predictors for the prognosis by modeling and simulation. Primary endpoint was clinical recurrence of ischemic stroke, and secondary endpoint was occurrence of any of the following clinical ...
Yashiro Yoshinori Y Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of - - 2014
Background:The difference between left atrial (LA) and systemic coagulation activity in paroxysmal atrial fibrillation (PAF) is unclear.Methods and Results:We enrolled 100 patients with PAF who underwent AF ablation. Warfarin was stopped 1 day before the procedure. LA volume index and LA emptying fraction were measured by 64-slice multidetector computed tomography. Immediately after ...
Lee Sung Ho SH Division of Cardiology, Department of Medicine, Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2014
Purpose: Recurrent syncope leads to poor functional status and psychiatric impairment in patients with syncope. The aim of the study was to prospectively analyze the risk factors attributed to syncope recurrence. Materials and Methods: Between 2009 and 2010, 289 patients with all cause of syncope visited our institution. Syncope recurrences ...
Efimova Irina I Federal State Budgetary Scientific Institution Research Institute for Cardiology, Tomsk, - - 2014
The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime ...
Flanagan Eoin P EP Department of Neurology, Mayo Clinic, Rochester, - - 2014
Short transverse myelitis (STM; <3 vertebral segments) is considered noncharacteristic of neuromyelitis optica (NMO) spectrum disorders (NMOSDs). Nonappreciation of the potential for STM to occur in NMOSD may lead to increased disability from delay in diagnosis and appropriate treatment. To determine the frequency of short lesions at the initial myelitis ...
Kamo Kenta K Department of Orthopaedic Surgery, Yamaguchi Red Cross Hospital , Yamaguchi , - - 2014
Objectives. We clarified the prevalence of spondyloarthritis (SpA) symptom in inflammatory bowel disease (IBD). Methods. We performed the questionnaire survey of SpA symptom in IBD patients on their office visit. Results. One hundred and thirty seven patients were evaluated. The SpA features group included 46 (33.6%) patients (32 Men). Among ...
Zardi Enrico Maria EM aDepartment of Clinical Medicine, 'Campus Bio-Medico' University, Rome bVI Department of Internal Medicine and Interventional Ultrasonography, Policlinico 'S. Matteo' Foundation, IRCCS, Pavia, - - 2014
Information is lacking on portal hypertensive gastropathy (PHG) in cirrhotics without varices; our aim it is to evaluate whether clinical and sonographic parameters are associated with PHG and may provide information suitable for the management of these patients. After endoscopic selection of 145 cirrhotics without varices, 75 with PHG and ...
Porcelli Brunetta B Department of Medical Biotechnologies, Biochemistry Division, University of Siena, Siena, - - 2014
Celiac disease (CD) is an immune-mediated intolerance to dietary gluten, affecting genetically predisposed individuals. ELISA-based serological tests help to decide if further duodenal biopsy is necessary, for this the diagnostic kits have to be accurate, specific, and sensible. In this study, we investigate the performance of an ELISA that uses ...
Lalosevic Jovan J Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, - - 2014
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases that are most frequently caused by drugs. The purpose of this study was to summarize 20 years of experience with SJS and TEN in the largest dermatology clinic in Serbia. The study included 38 patients treated during the period 1993-2012. ...
Bogert James N JN Department of Surgery, University of Texas Medical School at Houston, Houston, TX, - - 2014
Resuscitation of the hemorrhaging patient has undergone significant changes in the last decade resulting in the concept of damage control resuscitation (DCR). Hemostatic resuscitation aims to address the physiologic derangements found in the hemorrhaging patient, namely coagulopathy, acidosis, and hypothermia. Strategies to achieve this are permissive hypotension, high ratio of ...
Kaufman Michael M MS Center, Carolinas Medical Center, 1010 Edgehill Road North, Charlotte, NC, 28207, USA, - - 2014
The objective of this study is to characterize the timing and extent of radiologic MS disease recurrence during the 24-week natalizumab treatment interruption period in RESTORE. RESTORE was a randomized, partially placebo-controlled exploratory study. Natalizumab-treated patients with no gadolinium-enhancing (Gd+) lesions at screening (n = 175) were randomized 1:1:2 to continue natalizumab ...
Coblijn Usha K UK Department of Surgery, Sint Lucas Andreas Hospital, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands, - - 2014
One of the long-term complications of laparoscopic Roux-and-Y gastric bypass (LRYGB) is the development of marginal ulcers (MU). The aim of the present study is to assess the incidence, risk factors, symptomatology and management of patients with symptomatic MU after LRYGB surgery. A consecutive series of patients who underwent a ...
Panegyres Peter K PK Neurodegenerative Disorders Research Pty Ltd, 4 Lawrence Avenue, 6005, West Perth, WA, Australia, - - 2014
Our aim is to elucidate the clinical variables associated with the development of manifest HD in patients with intermediate CAG repeat lengths. 2,167 participants were seen throughout 44 research sites in the United States, Canada or Australia over a five-year natural history observational study (2006-2011) (Trial # NCT00313495). The Chi-square ...
Latus J J Division of Nephrology, Department of Internal Medicine, Robert-Bosch Hospital, Auerbachstraße 110, 70376, Stuttgart, Germany, - - 2014
Nephropathia epidemica is a milder form of hemorrhagic fever with renal syndrome, caused by Puumala virus. The clinical picture is characterized by a rapid loss of renal function (acute kidney injury) and thrombocytopenia. The purpose of the current analysis was to compare the clinical course of patients presenting with or ...
Kimbrough Dorlan J DJ Johns Hopkins University, Baltimore, MD, - - 2014
Objective: To determine whether African-American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian-American (CA) MS patients. Methods: 687 MS patients (81 AA) and 110 healthy control (HC) subjects (14 AA) were recruited at three academic hospitals between 2008 and 2012. Using mixed effects ...
Shirakabe Akihiro A Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical - - 2014
Background:Different mechanisms of acute kidney injury (AKI) may exist for acute heart failure (AHF) patients compared with other patients.Methods and Results:We analyzed data from 282 patients with AHF. The biomarkers were measured within 30 min of admission. Patients were assigned to a no-AKI (n=213) or AKI group (Class R (n=49), Class I ...
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