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Lund C C National Center for Epilepsy, Oslo University Hospital, Oslo, Norway; Department of Neurology, Vestfold County Hospital, Tønsberg, - - 2014
The prevalence of multiple sclerosis (MS) is increasing worldwide. Epileptic seizures are more common in MS patients than in the general population. The aim of this study was to investigate changes in the prevalence and incidence of MS in a well-defined population over several decades and estimate the occurrence of ...
Attivi David D CHOV, Site de Neufchâteau, Pharmacie, 1280, Avenue de la Division Leclerc, 88300, Neufchâteau, - - 2014
Background Patients with advanced cancers are at high risk for bone metastases, which accelerate bone resorption and skeletal complications. Therefore, bisphosphonates, which are strong inhibitors of bone resorption, are widely used to prevent pathological fractures, pain and tumour-induced hypercalcaemia. Intravenous infusion of bisphosphonate is associated with dose- and infusion rate-dependent ...
Senel Engin E Department of Dermatology, Hitit University Faculy of Medicine, Çankırı State Hospital, Çankırı, - - 2014
Tularemia is a serious and potentially life-threatening zoonosis caused by Francisella tularensis, a highly infective, gram-negative coccobacillus. Although there are plenty of case reports and studies of tularemia outbreaks, the literature is lacking in reports on dermatologic manifestations of the disease. This study aimed to identify skin manifestations in clinical ...
Haanstra Jasmijn F JF Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The - - 2014
The aim was to determine the prevalence of small-bowel neoplasia in asymptomatic patients with Lynch syndrome (LS) by video capsule endoscopy (VCE). After obtaining informed consent, asymptomatic proven gene mutation carriers aged 35-70 years were included in this prospective multicentre study in the Netherlands. Patients with previous small-bowel surgery were excluded. ...
Zhao Liang-Ping LP aDepartment of Cardiology, The First Affiliated Hospital of Soochow University bDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou City, China cDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore dDepartment of Mathematics & Statistics, Faculty of Engineering, Technology & Science, La Trobe University, Melbourne, Victoria, - - 2014
Previous studies have reported that insulin resistance is related to early in-stent restenosis (ISR) after coronary stenting. This study aimed to evaluate the influence of insulin resistance on the long-term angiographic outcome in patients undergoing coronary drug-eluting stent (DES) implantation. Within a single hospital-based cohort of patients (n=529) who underwent ...
Zhang Changming C National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, - - 2014
MicroRNAs (miRNAs) are stable in circulation, and their unique expression profiles can serve as fingerprints for various diseases. This study explored whether plasma miRNAs could be used as biomarkers to evaluate disease activity in patients with focal segmental glomerulosclerosis (FSGS). Retrospective and prospective cohorts. 78 patients with FSGS with nephrotic ...
Tsuruya Kazuhiko K Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: - - 2014
Brain atrophy has been reported in patients with end-stage renal disease receiving hemodialysis, although its mechanism is unknown. However, little is known regarding brain atrophy in patients receiving peritoneal dialysis (PD). Therefore, we examined brain volume and its annual change over 2 years in PD patients compared with patients with ...
Bellon Nathalia N Department of Dermatology, Hôpitaux Universitaires Henri Mondor, Créteil, - - 2014
Background: The value of anti-desmoglein 1 and 3 (Dsg1, Dsg3) enzyme-linked immunosorbent assay (ELISA) is controversial in the follow-up of pemphigus. Objective: To evaluate anti-desmoglein ELISA (Dsg ELISA) in the follow-up of pemphigus and compare ELISA with direct and indirect immunofluorescence in complete remission (CR). Methods: We performed a retrospective ...
Li Lin L Department of Dermatovenereology, Chengdu Second People's Hospital, No. 165, Caoshi Street, Chengdu, 610017, Sichuan, - - 2014
TNF-like ligand 1A (TL1A), a newly identified member of the TNF superfamily, has been proved as an important mediator of inflammation and critically involved in the pathogenesis of rheumatoid arthritis and several other autoimmune diseases. The aim of our study was to determine the possible role of TL1A in the ...
Prattes Juergen J Medical university of Graz, Section of Infectious Diseases, Graz, Austria ; - - 2014
Objectives Invasive pulmonary aspergillosis has been increasingly reported in non-neutropenic patients including those with underlying respiratory diseases. We compared the diagnostic performances of Galactomannan, 1,3-beta-D-glucan, and Aspergillus-specific lateral-flow device tests with that of conventional culture by using bronchoalveolar lavage fluid samples from patients with underlying respiratory diseases. Methods We analyzed ...
Timerbaeva Sofia L SL Department of Neurogenetics , and 2 Laboratory for Medical Statistics, Research Center of Neurology, Russian Academy of Medical Sciences (Volokolamskoye Shosse 80, Moscow 125367, Russia - - 2014
Abstract Purpose/Aim of the study - To analyze contribution of rs3842225 and rs1182 single nucleotide polymorphisms (SNP) in TOR1A gene, the causative gene for the DYT1 form of hereditary early-onset generalized dystonia, to the development of focal and segmental dystonia in Russian patients. Materials and methods - We analyzed associations ...
Jung Su Kyung SK Department of Ophthalmology and Visual Science, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, - - 2014
We compared the oxidative stress and antioxidant capacities of the medial rectus muscles (MRMs) between the patients with constant exotropia and control subjects. A total of 40 MRMs from patients with constant exotropia and 40 MRMs from normal donor eyes (controls) were assessed. Neuronal nitric oxide synthase (nNOS), superoxide dismutase ...
Marthey L L Kremlin Bicêtre University Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris-Sud University, Le Kremlin Bicêtre; Antoine Béclère University Hospital, AP-HP, Paris-Sud University, Clamart, - - 2014
Recently, a new enteropathy has been described: olmesartan-associated enteropathy. However, the association has been questioned: a phase 3 trial and a cohort study found no association between gastrointestinal events and olmesartan. We collected French cases of sartan-associated enteropathy to describe further this entity, confirm or refute causality, and determine if ...
Laursen Tea Lund TL Department of Hepatology and Gastroenterology, Aarhus University Hospital, - - 2014
The complement system is activated in liver diseases including acute liver failure (ALF); however, the role of the lectin pathway of complement has scarcely been investigated in ALF. The pathway is initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL), M-, L- and H-ficolin and collectin-liver-1 (CL-L1), which are predominantly ...
Astan Ramazan R Department of Cardiology, Batman Regional State Hospital, Batman, - - 2014
Cardiovascular complications are the leading causes of premature deaths in hemodialysis patients. Due to rapid changes in volume and electrolyte concentration following dialysis, the some electrocardiographic (ECG) changes or arrhythmias might be seen. To investigate the acute effects of hemodialysis on the ECG parameters in patients with chronic end-stage renal ...
Kaiser Ralf R Department of Internal Medicine, Saarland University Medical Centre, Homburg/Saar, - - 2014
In patients after the Fontan procedure, assessment of a failing Fontan circuit is difficult. Natriuretic peptides failed to be reliable markers of functional status or systemic ventricular function in this patient cohort. The aim of the study was to assess the clinical utility of mid-regional pro-adrenomedullin (MR-proADM) in patients after ...
Gao Liang L 1Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, 510080, - - 2014
Abstract To date, there are no definitive biomarkers for Parkinson's disease (PD) diagnosis. The detection of cerebrospinal fluid (CSF) alpha (α)-synuclein in PD patients has yielded promising but inconclusive results. To determine the performance of CSF α-synuclein as a diagnostic biomarker of PD and whether CSF α-synuclein can discriminate PD ...
Di Stefano Michele M 1st Department of Medicine, University of Pavia, IRCCS "S. Matteo" Hospital Foundation, Pavia, - - 2014
OBJECTIVES:Little information is available on the mechanisms responsible for dyspeptic symptoms in postprandial distress syndrome (PDS), characterized by the presence of prevalently meal-related early satiation and fullness, and the epigastric pain syndrome (EPS), characterized by the prominent symptom of epigastric pain, generally not meal related. In a group of PDS ...
Crestani E E Division of Immunology, Children's Hospital Boston, Boston, - - 2014
Glatiramer acetate (Copaxone) is a polymer of four amino acids and it closely resembles myelin basic protein. It is widely used as a disease-modifying agent with established efficacy in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS)(1) . Glatiramer acetate is usually dosed as a 1 mL subcutaneous daily ...
Francia Pietro P Division of Cardiology, Department of Clinical and Molecular Medicine, St. Andrea Hospital, Sapienza University, Rome, - - 2014
Hypertension entails atrial remodeling that affect P-wave (PW) duration on electrocardiogram (ECG). PW indices (e.g., variance, dispersion, and terminal force) are associated with a higher risk for atrial fibrillation (AF), but their calculation requires multiple measurements of PW duration, limiting their use in clinical practice. We evaluated whether PW duration ...
Hung Adriana M AM CSR&D, Veterans Administration Tennessee Valley Healthcare System, Nashville, TN, USA Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, - - 2014
Chronic systemic inflammation is common in patients with chronic kidney disease on dialysis (CKD5D) and has been considered a key mediator of the increased cardiovascular risk in this patient population. In this study, we tested the hypothesis that supplementation of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) will attenuate the systemic ...
Almeida David R P DR *Vitreoretinal Service, Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and †Department of Ophthalmology, Queen's University, Hotel Dieu Hospital, Kingston, - - 2014
To analyze the factors that may predict the release of vitreomacular traction (VMT) and vitreomacular adhesion. Retrospective case-control study of sixty-one patients with VMT imaged by optical coherence tomography over at least 3 months. Records from all patients seen at the University of Iowa from January 2012 to September 2013 ...
Turner Kevin K *Miraca Life Sciences Research Institute, Irving, Texas; and †Department of Medicine, Oregon Health & Sciences University, Portland, - - 2014
The relevance of granulomas in biopsy specimens from patients with Crohn's disease is largely unknown. Most previous studies have been performed on small samples and have produced conflicting results. This study was designed to compare the demographic, clinical, and histopathologic characteristics of a large cohort of documented patients with Crohn's ...
Wattjes Mike P MP Department of Radiology and Nuclear Medicine, MS Center Amsterdam, VU University Medical Center, Amsterdam, The - - 2014
To investigate the MRI manifestation pattern of asymptomatic natalizumab-associated progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis (MS). 18 patients with MS with natalizumab-associated PML lesions on MRI were included. In 6 patients, the PML lesions were identified on MRI prospectively and in 12 patients PML lesions were identified ...
Ramyead Avinash A University of Basel Psychiatric Clinics, Center for Gender Research and Early Detection, - - 2014
Converging evidence indicates that neural oscillations coordinate activity across brain areas, a process which is seemingly perturbed in schizophrenia. In particular, beta (13-30 Hz) and gamma (30-50 Hz) oscillations were repeatedly found to be disturbed in schizophrenia and linked to clinical symptoms. However, it remains unknown whether abnormalities in current ...
Cheng Fa-Juan FJ Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, - - 2014
Human neutrophil peptides (HNP) were recently implicated in the neutrophil extracellular trap (NET) complex, the impaired degradation of which has been associated with lupus nephritis (LN). Forty LN patients, 40 SLE patients without kidney injury, 63 immunoglobulin A nephropathy (IgAN) patients, 20 minimal change disease (MCD) patients and 33 healthy ...
Lewis Robert K RK Cardiac Electrophysiology Section, Duke Heart Center, Duke University Medical Center, Durham, North - - 2014
Preprocedural multidetector computed tomography (MDCT) may identify patients at risk for mechanical complications during lead extraction. To describe the use and feasibility of computed tomography scanning for preprocedural planning of lead extraction, we conducted a retrospective study of high-risk patients, who underwent electrocardiogram (ECG)-gated MDCT before planned lead extraction between ...
Jeong Hyemin H Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South - - 2014
To evaluate the clinical characteristics and outcomes of nonradiographic axial spondyloarthritis (nr-axSpA) in Korean patients. A retrospective analysis evaluated 155 patients with nr-axSpA at a single tertiary hospital between January 2001 and January 2011. Baseline characteristics and clinical courses were reviewed and compared with those of patients with ankylosing spondylitis ...
Li Xiuhui X From the 1 Department of Integrated TCM and Western Medicine, Beijing Youan Hospital affiliated with Capital Medical University , - - 2014
Background: Hand, foot, and mouth disease (HFMD) is a common infectious disease in children, characterized by acute viral infection accompanying acute inflammatory responses. Circulating histones are leading mediators of the inflammatory processes. This study aimed to elucidate whether circulating histones play a contributory role during HFMD. Methods: We measured plasma ...
Ong Bryan B From the *Division of Digestive and Liver Diseases, and the Department of Internal Medicine, University of Texas Southwestern Medical Center and Parkland Memorial Hospital, Dallas, TX; and †Department of Internal Medicine, Medical University of South Carolina, Charleston, - - 2014
Hemoglobin/hematocrit decreases in hospitalized patients without evidence of obvious gastrointestinal (GI) bleeding are common and often attributed to GI lesions. We hypothesized that inpatients with hematocrit declines without clinically overt GI bleeding have distinct clinical features and hence aimed to evaluate this clinical syndrome. We evaluated consecutive GI consults for ...
Chirico Valeria V Department of Pediatric Sciences, University of Messina, Messina, - - 2014
Endocrinopathies and metabolic disorders characterized β thalassemic (βT) patients and the prevention and treatment of these comorbidities are important targets to be achieved. The aim of the study was to analyse the diagnostic and prognostic role of ferritin for endocrinopathies and metabolic disorders in βT patients. Ability of iron chelators ...
Cavazzana Ilaria I Rheumatology and Clinical Immunology Unit, Spedali Civili di Brescia, Brescia, Italy. - - 2014
Aseptic meningitis is a rare and aggressive complication of rheumatoid arthritis (RA), usually histologically characterised by rheumatoid nodules and lymphocytic aggregates in leptomeninges. The aim of this study was to describe the clinical onset and evolution of aseptic meningitis occurring during anti-TNF-alpha (TNF-) therapy. we retrospectively analysed the clinical records ...
Dreimann Marc M 1Department of Trauma, Hand and Reconstructive Surgery, University Hospital Hamburg Eppendorf / Germany 2Department of Medical Psychology, University Hospital Hamburg Eppendorf, Germany 3Research Office, Biostatistics, Paracelsus Medical University, Salzburg / Austria 4German Scoliosis Center Bad Wildungen, Werner-Wicker-Klinik, Bad Wildungen / - - 2014
Study Design. This study examines the correlations between pulmonary function tests (PFTs) and radiographic measures of spinal deformities in scoliosis patients.Objective. To define the parameters that enable more accurate predictions of restricted PF in scoliosis patients.Summary of Background Data. The early identification of scoliosis patients who are at risk of ...
Adrie Christophe C 1Physiology department, Cochin Academic Hospital, Paris Descartes University, Sorbonne Cite, Paris, France 2Pasteur Institute, Cytokines & Inflammation Unit, Department of Infections and Epidemiology, Paris, France. 3Cardiac Surgery Department, Paris Saint-Joseph Hospital, Paris Descartes University, Paris, France 4Cardiac Surgery Department, Marie-Lannelongue Hospital, Le Plessis-Robinson, France 5Critical Care Unit, Melun General Hospital, Melun, - - 2014
To determine whether the good safety profile of transcatheter aortic valve implantation (TAVI) is related to lower levels of systemic bacterial translocation and systemic inflammation compared to open heart surgery. TAVI via the transfemoral approach is increasingly used in very high risk patients with aortic stenosis. The outcomes seem similar ...
Ozeki Michishige - - 2014
Expression and/or excretion of fibroblast growth factor-23 (FGF23) and its co-receptor Klotho are altered in patients with end-stage renal disease. The possibility that the FGF23/alpha-Klotho system mediates the aggravated cardiovascular outcome among patients with chronic kidney disease (CKD) has been suggested. We determined whether FGF23 and alpha-Klotho concentrations are altered ...
Cattrysse Fabienne - - 2014
Obstructive sleep apnea and hypopnea syndrome (OSAHS) is a disorder that causes clinical symptoms (e.g. snoring, excessive daytime sleepiness and impaired concentration) that may increase the risk of traffic accidents, cardiovascular disease, type 2 diabetes and reduce the quality of life. A recently developed device (Somnolter(R)) detects apneas and hypopneas ...
Santangelo Roberto R Department of Neurology, San Raffaele Scientific Institute, Milan, - - 2014
Background: Three variants of primary progressive aphasia (PPA) have been currently characterized: non fluent/agrammatic (nfv-PPA), semantic (sv-PPA), and logopenic variant (lv-PPA). lv-PPA is most commonly associated with Alzheimer's disease (AD), while nfv-PPA and sv-PPA are related to frontotemporal lobar degeneration. Objective: We aimed to determine whether cerebrospinal fluid (CSF) amyloid-β42 ...
Ter Bekke Rachel M A RM Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The - - 2014
Prolonged and dispersed left-ventricular (LV) contraction is present in patients with long-QT syndrome (LQTS). Electrical and mechanical abnormalities appear most pronounced in symptomatic individuals. We focus on the 'electromechanical window' (EMW; duration of LV-mechanical systole minus QT interval) in patients with genotyped LQTS. Profound EMW negativity heralds torsades de pointes ...
Fijak Monika M Department of Anatomy and Cell Biology, Justus-Liebig University of Giessen, Aulweg 123, 35392 Giessen, Germany - - 2014
Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions? In sera from infertile azoospermic patients with histologically confirmed low-grade testicular inflammation, significantly elevated titers of autoantibodies against disulfide isomerase family A, member 3 (ER-60) were found. Infection and inflammation of the genital tract are supposed to be ...
Phan Kevin H KH Department of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA. Electronic address: - - 2014
Degenerative spondylolisthesis is a common pathological condition which leads to lumbar instability and significant clinical symptoms. The effect of this pathology on adjacent lumbar motion segments, however, has not yet been studied. The purpose of this study was to characterize the motion characteristics of lumbar degenerative spondylolisthesis at both the ...
Gazdag A A Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, P.O.B. 19, Debrecen, 4012, Hungary, - - 2014
The aim of this study was to investigate aortic stiffness and left ventricular (LV) systolic and diastolic function in patients with differentiated thyroid cancer (DTC) on thyroxine (L-T4) therapy and after L-T4 withdrawal to assess the cardiovascular impact of long-term subclinical hyperthyroidism and short-term overt hypothyroidism. Twenty-four patients who had ...
Shochat Michael M Heart Institute, Hillel Yaffe Medical Center, P.O. Box 169, 38100, Hadera, Israel, - - 2014
The instantaneous lung impedance (ILI) is one of the methods to assess pulmonary congestion or edema (PCE) in chronic heart failure (CHF) patients. Due to usually existing PCE in CHF patients when evaluated, baseline lung impedance (BLI) is unknown. Therefore, the relation of ILI to BLI is unknown. Our aim ...
Yanaba Koichi K Department of Dermatology, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-Ku, Tokyo, 105-8641, Japan, - - 2014
Obesity is thought to be involved in the pathogenesis of psoriasis, although its impact on the therapeutic response to systemic treatments remains unclear. The aim of this study was to examine the association of body mass index (BMI) with the efficacy of ustekinumab in Japanese patients with psoriasis. Clinical data ...
Honjo Hirotaka H Department of Surgery, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan, - - 2014
Intussusception is common in children but rare in adults. The goal of this study was to review retrospectively the symptoms, diagnosis, and treatment of intussusception in adults. From 1997 to 2013, we experienced 44 patients of intussusception in patients older than 18 years. The patients were divided into enteric, ileocolic, ileocecal, ...
Wu Chan C Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Road, DongCheng District, Beijing 100730, - - 2014
To investigate clinical characteristics of Purtscher-like retinopathy and its clinical implications among patients with systemic lupus erythematosus (SLE). Observational case series. Methods: SETTING: Tertiary medical center. Patients with SLE who were diagnosed with Purtscher-like retinopathy between 2002 and 2013. Assessment and follow-up in the ophthalmology department. Visual acuity and funduscopic ...
Holinski Franca F Department of Otorhinolaryngology, Head and Neck Surgery, University Medicine Berlin, Berlin, - - 2014
Background: Multiple sclerosis (MS) is a chronic disease characterized by CNS lesions causing physical and cognitive impairment. Using psychophysical testing, an olfactory disorder is diagnosed in 15-38.5% of patients with MS. Olfactometry permits objective testing of the sensory nerve function. Methods: The study looked at 20 patients with MS. Clinical, ...
Allaix Marco E ME Center for Esophageal Diseases and Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 5031, Chicago, IL, 60637, USA, - - 2014
Esophageal epiphrenic diverticulum (ED) is usually secondary to a primary esophageal motility disorder, such as achalasia. Whereas the recommended surgical treatment includes esophageal myotomy and diverticulectomy, the outcome of patients in whom a myotomy without ED resection is performed is not known. The purpose of this study was to compare ...
Charbonneau Hélène - - 2014
IntroductionEchocardiographic indices based on respiratory variations of superior and inferior vena cava diameters (¿SVC and ¿IVC, respectively) have been proposed as predictors of fluid responsiveness in mechanically ventilated patients but they have never been compared simultaneously in the same patient sample. The aim of this study was to compare the ...
Vanmassenhove J J Renal Division, Nephrology Section, 0K12, Ghent University Hospital, De Pintelaan 185, B9000, Ghent, Belgium, - - 2014
The pathophysiology of septic acute kidney injury (AKI) is incompletely understood, and there is controversy on the role of renal hypoperfusion in early sepsis. We hypothesized that renal hypoperfusion plays a role in early sepsis and that there is a continuum between transient AKI without tubular damage, transient AKI with ...
Zhao Jinxia J Department of Rheumatology & Immunology, Peking University Third Hospital, Beijing, 100191, China. - - 2014
To develop classification criteria for early rheumatoid arthritis (ERA) based on a large cohort of early inflammatory arthritis patients and to evaluate the performance of these criteria. The study population comprised a cohort of early inflammatory arthritis patients with symptom duration less than one year. Classification criteria of ERA were ...
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