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Dohan Anthony A Department of Abdominal and Interventional Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 2 rue Ambroise Paré, 75010, Paris, France, - - 2014
To assess the role and effectiveness of percutaneous arterial embolization (TAE) in patients with hemodynamic instability due to hypovolemic shock secondary to ruptured splanchnic artery pseudoaneurysms (SAPA). Seventeen patients (11 men, 6 women; mean age, 53 years) with hemodynamic instability (systolic blood pressure <90 mmHg) due to hypovolemic shock secondary to ruptured ...
Chiara Tani T Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, - - 2014
In this study we aimed to describe the magnetic resonance imaging (MRI) pattern of the distribution of bone marrow edema (BME) and joint erosion in hands and wrists of patients with systemic lupus erythematosus (SLE) with arthritis in comparison with rheumatoid arthritis (RA) and healthy subjects (H). SLE patients with ...
Heyer Eric J EJ Departments of - - 2014
OBJECT Neurocognitive performance is used to assess multiple cognitive domains, including motor coordination, before and after carotid endarterectomy (CEA). Although gross motor strength is impaired with ischemia of large cortical areas or of the internal capsule, the authors hypothesize that patients undergoing CEA demonstrate significant motor deficits of hand coordination ...
Naderi Gholamhossein G Department of Urology and Kidney Transplantation, Dr. Shariati Hospital, Tehran University of Medical Sciences , Tehran , - - 2014
Varicocele, the most common cause of male infertility, is defined as abnormal dilation of the pampiniform plexus. Although different mechanisms have been proposed to explain the pathophysiology of infertility caused by varicocele, it is still open to debate. Previous studies have demonstrated the effect of insulin-like growth factor-I (IGF-I) on ...
Franken R R Department of Cardiology, Academic Medical Centre Amsterdam, Amsterdam, the - - 2014
Recently, we demonstrated that losartan reduced the aortic root dilatation rate (AoDR) in adults with Marfan syndrome (MFS); however, responsiveness was diverse. The aim was to determine the role of transforming growth factor-β (TGF-β) as therapeutic biomarker for effectiveness of losartan on AoDR. Baseline plasma TGF-β levels of 22 healthy ...
Höftberger Romana R Center of Neuroimmunology, Service of Neurology, Hospital Clínic and Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain/Institute of Neurology, Medical University of Vienna, Austria/These authors contributed equally to this - - 2014
We aimed to report the frequency and implications of antibodies to myelin oligodendrocyte glycoprotein (MOG-ab) in adults with demyelinating syndromes suspicious for neuromyelitis optica (NMO). Samples from 174 patients (48 NMO, 84 longitudinally extensive myelitis (LETM), 39 optic neuritis (ON), and three acute disseminated encephalomyelitis (ADEM) who presented initially with ...
Uzawa Akiyuki A Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, - - 2014
High mobility group box 1 (HMGB1) functions as an inflammatory mediator and is implicated in the pathogenesis of various autoimmune diseases. Our primary aim is to determine whether HMGB1 is involved in the pathogenesis of myasthenia gravis (MG). Serum HMGB1 levels of 60 patients with anti-acetylcholine receptor (AChR) antibody-positive MG ...
Lu Z-H ZH Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, 100029, Beijing, Chaoyang District, P.R. - - 2014
The aim of this study was to evaluate whether the levels of HbA1c could predict the outcome of ablation in patients with type 2 diabetes mellitus (T2DM) and paroxysmal atrial fibrillation (PAF). The study comprised 149 consecutive patients with T2DM and PAF who underwent their first circumferential pulmonary vein isolation. ...
Gutiérrez-Adrianzén O A OA Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, - - 2014
The pathophysiological mechanisms of arterial hypertension during hemodialysis (HD) in patients with end-stage renal disease (ESRD) are still poorly understood. The aim of this study is to investigate physiological, cardiovascular and neuroendocrine changes in patients with ESRD and its correlation with changes in blood pressure (BP) during the HD session. ...
Koseekriniramol Vasan V Department of Diagnostic and Therapeutic Radiology, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchatewi, Bangkok, 10400, - - 2014
To evaluate clinical and imaging factors for potential use in predicting appendix visualization on sonography (US) of adult patients with suspected appendicitis. All adult patients who underwent appendiceal US from January through June 2010 were included in this retrospective study. Clinicopathological records were reviewed for age, sex, weight, body mass ...
Patay Zoltan Z Department of Radiological Sciences, St. Jude Children's Research Hospital and Research Center, Memphis, TN, USA, - - 2014
Patients with L-2-hydroxyglutaric aciduria are at risk for developing cerebral neoplasms, particularly gliomas, as one of the optical isomers of the known oncometabolite, 2-hydroxyglutarate is produced in L-2-hydroxyglutaric aciduria. To illustrate the concept of sustained oncogenic potential in permanent exposure to L-2-hydroxyglutarate in brain tissue, we present the medical history ...
Zhang Yuzhou Y Molecular Otolaryngology and Renal Research - - 2014
C3 glomerulopathy (C3G) applies to a group of renal diseases defined by a specific renal biopsy finding: a dominant pattern of C3 fragment deposition on immunofluorescence. The primary pathogenic mechanism involves abnormal control of the alternative complement pathway, although a full description of the disease spectrum remains to be determined. ...
Lagana Stephen M SM Department of Pathology and Cell Biology, Columbia University and New York Presbyterian Hospital, New York, New York, - - 2014
A severe syndrome characterised by life-threatening diarrhoea and severe sprue-like histology has been described in patients taking the angiotensin receptor blocker (ARB) olmesartan. It is unknown whether there are any histopathological changes in patients without severe diarrhoea exposed to this medication. It is also unknown whether other ARBs cause sprue-like ...
Cai Cindy X CX Columbia University, New York, NY, 10032, United - - 2014
Purpose:In patients with retinitis pigmentosa (RP), the ellipsoid zone (EZ aka IS/OS border) is a marker of the usable visual field at a given point in time and of the progression of the disease over time. Here we compare the change in the width per year of the EZ band ...
Sen Hanim H Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The - - 2014
Aims: Drug-eluting stents (DES) were first used on-label - in simple patients with low clinical risk and easily accessible lesions. Currently, DES are increasingly used off-label - in complex patients undergoing percutaneous coronary interventions (PCI) with historically higher event risk. Therefore, our aim was to investigate whether patients with off-label ...
Ishido Naoko N Osaka University Graduate School of Medicine, Department of Biomedical Informatics, Division of Health Science , 1-7, Yamadaoka , Suita, Japan, 565-0871 , +81-6-6879-2596 , +81-6-6879-2596 ; - - 2014
Background: Autoimmune thyroid diseases (AITDs) predominantly develop in females. One of two X chromosomes is randomly inactivated by methylation in each female cell, but it has been reported that skewed X chromosome inactivation (XCI) may be associated with the development of autoimmune diseases. To clarify the significance of skewed XCI ...
Eder Piotr P 1Department of Gastroenterology,Human Nutrition and Internal Diseases,Poznan University of Medical - - 2014
A case of agomelatine-induced hepatotoxicity is described in a 47-year female patient who has received the drug, 25 mg/day, for 4 months, for the treatment of depression. The patient was admitted to the Department of Gastroenterology because of fatigue and nausea, with concomitant elevation of alanine aminotransferase (ALT), 550 U/L, ...
Seifert Claudia C Section for Hematology and Oncology, Department of Pediatrics, Jena University Hospital, Kochstraße 2, 07740, Jena, - - 2014
Sinusoidal obstruction syndrome (SOS) is a life-threatening early complication after hematopoietic stem cell transplantation (HSCT), and until now, examinations about the influence of genetic risk factors are extremely rare. The purpose of this study was to identify an association between heparanase (HPSE) single nucleotide polymorphisms (SNPs) and SOS in children ...
Valimahamed-Mitha Sarah S Service de Pneumologie pédiatrique, Hôpital Jeanne de Flandre, CHRU de Lille, Paris, France, - - 2014
Lysinuric protein intolerance (LPI) is a rare multisystemic metabolic disease. The objective of the study was to describe presentation and course of lung involvement in a cohort of ten children. Retrospective review of patients followed at Necker-Enfants Malades University Hospital between 1980 and 2012 for a LPI. In patients with ...
De Backer Ole - - 2014
Some patients with Takotsubo cardiomyopathy (TTC) develop cardiogenic shock due to left ventricular outflow tract (LVOT) obstruction - there is, however, a paucity of data regarding this condition. Prevalence, associated factors and management implications of LVOT obstruction in TTC was explored, based on two-year data from two Belgian heart centres. ...
Chen Yung-Lung YL Division of cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of - - 2014
Aim: Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31(+)CD42b(-)AN(-)V(+)) and platelet-derived apoptotic microparticles (PDA-MPs; CD31(+)CD42b(+)AN(-)V(+)) are useful biomarkers for predicting the presence of cardiorenal disease (CRD). Methods: A total of 68 patients with chronic ...
Nemani Venu M VM 1Spine and Scoliosis Service, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY 2Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, - - 2014
Study Design. Retrospective case seriesObjective. To determine whether cord signal change visualized on MRI correlates with level-specific physical exam findings as well as other signs of cervical myelopathy.Summary of Background Data. While cord signal change (CSC) is often used as a marker for severe cervical spine pathology, it is not ...
Martínez-Castelao Alberto - - 2014
Background and objective: C.E.R.A. (continuous erythropoietin receptor activator, pegilated-rHuEPO &szlig;) corrects and maintains stable hemoglobin levels in once-monthly administration in chronic kidney disease (CKD) patients. The aim of this study was to evaluate the management of anemia with C.E.R.A. in CKD patients not on dialysis in the clinical setting. Methods: ...
McNeil Brian K - - 2014
Among genitourinary malignancies, bladder cancer (BCa) ranks second in both prevalence and cause of death. Biomarkers of BCa for diagnosis, prognosis and disease surveillance could potentially help prevent progression, improve survival rates and reduce health care costs. Among several oncogenic signaling pathways implicated in BCa progression is that of hepatocyte ...
Jeganathan Niranjan N Division of Pulmonary and Critical Care Medicine, Rush University Medical Center and Rush Medical College, Chicago, Illinois. - - 2014
Several patient populations have been identified as high risk for extubation failure despite successful completion of a spontaneous breathing trial (SBT). Extubation failure and subsequent need for emergent re-intubation have been associated with increased morbidity and mortality. In this review, we discuss ways to optimize the value and performance of ...
Kim Won W Genitourinary Medical Oncology, UCSF Helen Diller Family Comprehensive Cancer Center - - 2014
Purpose: Patients previously treated with ketoconazole were excluded from phase III trials of abiraterone acetate due to potential overlapping mechanism of action. The purpose of this study was to determine the clinical utility of abiraterone and its impact on circulating androgens following ketoconazole. Experimental Design: Chemotherapy-naïve patients with progressive metastatic ...
Benezet-Mazuecos Juan J Department of Cardiology, Hospital Universitario Fundación Jiménez Díaz - IDC salud, Universidad Autónoma de Madrid, Avenida Reyes Católicos 2, Madrid 28040, Spain - - 2014
Monitoring capabilities of cardiac implantable electronic devices have revealed that a large proportion of patients present silent atrial fibrillation (AF) detected as atrial high rate episodes (AHREs). Atrial high rate episodes >5 min have been linked to increased risk of clinical stroke, but a high proportion of ischaemic brain lesions ...
Hammoud Ghassan M GM Ghassan M Hammoud, Jamal A Ibdah, Division of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO 65212, United - - 2014
Endoscopic ultrasound (EUS) has revolutionized the diagnostic and therapeutic approach to patients with gastrointestinal disorders. Its application in patients with liver disease and portal hypertension is increasing. Patients with chronic liver disease are at risk for development of portal hypertension sequale such as ascites, spontaneous bacterial peritonitis and gastroesophageal varices. ...
Shiotani Akiko A aDepartment of Internal Medicine, Division of Gastroenterology bDepartment of Clinical Pathology and Laboratory Medicine cDepartment of Comprehensive Medicine, Kawasaki Medical School, Okayama, - - 2014
PillCam patency capsule (PC) is a novel and radiofrequency identification tag-free device that remains intact in the gastrointestinal tract for 30-33 h after ingestion and then disintegrates. The aim of this study was to determine the clinical relevance of PC combined with abdominal ultrasonography as a reliable indicator of functional patency. ...
Jiang Ping P aThe Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health bDepartment of Cardiology, Beijing Tiantan Hospital, Capital Medical University cLaboratory of Electron Microscopy, Peking University First Hospital, Beijing, - - 2014
It is well known that the interaction between platelets (PLTs), endothelial cells, and leukocytes contributes to thrombosis in patients with acute coronary syndrome. The aim of this study was to investigate the significance of PLTs and eosinophils (EOS) in coronary arterial thrombi. PLT count, mean PLT volume, PLT mass, EOS ...
Imperatori Claudio C Department of Human Sciences, European University of Rome, Via degli Aldobrandeschi 190, 00163, Rome, Italy, - - 2014
We evaluated the modifications of electroencephalographic (EEG) power spectra and EEG connectivity in overweight and obese patients with elevated food addiction (FA) symptoms. Fourteen overweight and obese patients (3 men and 11 women) with three or more FA symptoms and fourteen overweight and obese patients (3 men and 11 women) ...
Nowroozi Mohammad Reza MR Department of Urology, Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran, - - 2014
To assess the role of power and color Doppler ultrasonography (US) in patients with azoospermia prior to testicular sperm extraction. One hundred and thirty consecutive patients with azoospermia were assessed in this prospective study. Based on a semiquantitative method, the results of power Doppler US were graded into three categories: ...
Kamath Ashwin A AA Department of Neurological Surgery, St. Louis Children's Hospital, Washington University School of Medicine, One Children's Place, Suite 4S20, St. Louis, MO, 63110, USA, - - 2014
Patients who have undergone hemispherotomy for intractable epilepsy tend to develop postoperative fevers, which can be severe and/or prolonged, for unclear reasons. The purpose of this paper is to characterize postoperative fever curves after hemispherotomy based on factors including seizure etiology, perioperative blood loss, and the presence or absence of ...
Zhang Huan H - - 2014
ObjectiveTo evaluate the effect of dehydroepiandrosterone (DHEA) on infertility patients with diminished ovarian reserve undergoing in vitro fertilization.MethodsThis is a prospective study. Ninety-five patients with diminished ovarian reserve were included in this study. Of them, 42 patients were randomly allocated to the DHEA group, who received DHEA 75 mg daily ...
Wu L M LM Department of Surgery, University of Auckland, Auckland, New - - 2014
The gut is implicated in the pathogenesis of acute pancreatitis but there is discrepancy between individual studies regarding the prevalence of gut barrier dysfunction in patients with acute pancreatitis. The aim of this study was to determine the prevalence of gut barrier dysfunction in acute pancreatitis, the effect of different ...
Rosas José J Department of Rheumatology, Marina Baixa Hospital, Villajoyosa, Alicante, Spain. - - 2014
The aim of this paper is to assess the usefulness of measuring serum levels of adalimumab (ADL) and anti-ADL antibodies in 57 patients with rheumatoid arthritis (RA) treated with ADL for at least 3 months in daily practice. All patients received concomitant disease-modifying anti-rheumatic drug (DMARD). Receiver-operator characteristics (ROC) analysis ...
Sivula M M Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, - - 2014
Matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinases-1 (TIMP-1) have recently been suggested to be involved in coagulation process. Our objectives were to observe systemic MMP-8 and TIMP-1 levels in patients with severe sepsis with or without disseminated intravascular coagulation (DIC) and to study their relationship with coagulation markers over ...
Saguner Ardan M AM Department of Cardiology, University Heart Center - - 2014
Background:The clinical role of atrial fibrillation/atrial flutter (AF-AFl) and variables predicting these arrhythmias are not well defined in patients with arrhythmogenic right ventricular dysplasia (ARVD). We hypothesized that transthoracic echocardiography (TTE) and 12-lead electrocardiography (ECG) would be helpful in predicting AF-AFl in these patients.Methods and Results:ECGs and TTEs of 90 patients diagnosed ...
Gordon Monica - - 2014
IntroductionExternal ventricular drainage (EVD)-related ventriculitis is one of the most severe complications associated with the use of EVDs. Establishing an early and certain diagnosis can be difficult in critically ill patients. We performed this prospective study to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) determination ...
Tapolyai Mihály M Fresenius Medical Care Hungary, Semmelweis University, Budapest, Hungary; Carolinas Campus, Edward Via Osteopathic College of Medicine, Spartanburg, - - 2014
The authors examined the relationship between thiazide-type diuretics and fluid spaces in a cohort of hypertensive patients in a retrospective study of 60 stable hypertensive patients without renal abnormalities who underwent whole-body bioimpedance analysis. Overhydration was greater in the diuretic group, but only to a nonsignificant degree (5.9 vs 2.9%; ...
Talib Ahmed Karim AK Department of Cardiology, Asahikawa Medical University; Department of Laboratory Medicine, Asahikawa Medical - - 2014
We reported impaired QT-rate dependence in early repolarization syndrome (ERS); however, contemporary data have shown peak incidence of sudden cardiac death (SCD) in ERS and Brugada syndrome (BrS) at mid-night and early morning. Taken together, we analyzed the nocturnal QT-rate dependence in both syndromes. A total of 172 subjects were ...
Tian Ying - - 2014
The CpG island methylator phenotype (CIMP) of clear cell renal cell carcinomas (ccRCCs) is characterized by accumulation of DNA methylation at CpG islands and poorer patient outcome. The aim of this study was to establish criteria for prognostication of patients with ccRCCs using the ccRCC-specific CIMP marker genes. DNA methylation ...
Narang Neera S NS Division of Immunology and Rheumatology, Stanford University, Stanford, - - 2014
Objective: To identify clinical and serologic correlates of cutaneous ulcers in dermatomyositis (DM). Methods: We retrospectively examined a cohort of 152 DM patients. We compared the features of patients with ulcers to those without ulcers using chi-squared or Fisher's exact tests and used univariate and multivariate logistic regression models to ...
Mahan Susan T ST Departments of *Orthopaedics §Orthopaedic Surgery, Boston Children's Hospital †Department of Orthopaedic Surgery ∥Catharine Ormandy Professor of Orthopaedic Surgery, Harvard Medical School ‡Harvard Combined Orthopaedic Residency Program, Boston, - - 2014
There are little patient-reported data on functional outcomes of tarsal coalition resection in children and adolescents. The purpose of this study is to evaluate the medium-term (>2 y) outcomes in patients who have had surgical excision of their symptomatic tarsal coalition and to compare patient-based outcomes in patients who have ...
Hu Ching-Yun CY The Intensive Care Unit, Taichung Veterans General Hospital, Taichung, Taiwan, - - 2014
Acetazolamide-related hypophosphatemia leading to cardiac arrest is extremely rare. Herein we report a 78-year-old female glaucoma patient who developed general weakness and acute respiratory failure, followed by cardiac arrest 1 day after taking acetazolamide. The patient was successfully weaned from the ventilator after correction of hypophosphatemia and fully recovered. As ...
Jafarzadeh A A Neurology Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran, - - 2014
The regulatory T (Treg) cells play a major role in the control of the autoimmunity and inflammation, and IL-35 has been described as an immunosuppressive cytokine that is mainly produced by CD4(+) FOXP3(+) Treg cells. The aim of this study was to evaluate the serum levels of IL-35 and a ...
Berger Steve S Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstrasse 78, 3014, Bern, Switzerland, - - 2014
The clinical tests currently used to assess spinal biomechanics preoperatively are unable to assess true mechanical spinal stiffness. They rely on spinal displacement without considering the force required to deform a patient's spine. We propose a preoperative method for noninvasively quantifying the three-dimensional patient-specific stiffness of the spines of adolescent ...
Tscholl Philippe M PM Department of Orthopedic Surgery, Orthopedic University Hospital Balgrist, University of Zurich, Zurich, Switzerland, - - 2014
Increased tibial tubercle trochlear groove distance (TT-TG) is frequently associated with trochlear dysplasia (TD). Since the trochlear groove appears more distally in patients with TD compared to controls, it is unknown whether TT-TG might be comparable and meaningful. Fifty patients with TD were retrospectively analysed and compared to 52 age- ...
Wang Zhong-Xia ZX Department of Graduate School, 301 Hospital, Beijing, China; Integrative Medical Centre, 302 Hospital, Beijing, - - 2014
Caroli's disease (CD) is a rare congenital disorder. The early diagnosis of the disease and differentiation of types I and II are of extreme importance to patient survival. This study was designed to review and discuss observations in 30 patients with CD and to clarify the clinical characteristics of the ...
Verrotti Alberto A Department of Pediatrics, University of Perugia, Perugia, Italy, - - 2014
Prader-Willi syndrome is a multisystemic genetic disorder that can be associated with epilepsy. There is insufficient information concerning the clinical and electroencephalographic characteristics of epilepsy and the long-term outcome of these patients. The aim of this study is to describe seizure types, electroencephalographic patterns and long-term seizure outcome in Prader-Willi ...
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