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Lenz Philipp P Philipp Lenz, Franziska Eckelskemper, Frank Lenze, Torsten Beyna, Hansjörg Ullerich, Andre Schmedt, Dirk Domagk, Department of Medicine B, University of Muenster, D-48149 Muenster, - - 2014
To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis. We performed a prospective study of 127 patients who underwent endoscopic retrograde cholangiopancreatography, for various biliary disorders, at 3 tertiary referral centers in Germany from July 2011 through July 2012 (ClinicalTrials.gov: NCT01109550). Bile, buccal, and ...
Desbois Anne - - 2014
Background/aimsBehcet¿s disease (BD) is a well-known cause of Budd-Chiari syndrome (BCS). Data are lacking on the presentation and outcome of BCS related to BD.MethodsWe investigated the relationship between BD and BCS in 14 patients with both diseases and compared the results to 92 BCS patients without BD.ResultsMale gender (p¿=¿0.003), North ...
Hijioka Masayuki M Department of Medicine and Bioreguratory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, - - 2014
Although chromogranin A (CGA) is a useful marker for pancreatic neuroendocrine tumors (pNETs) in the West, its usefulness in Japanese populations is unclear. To assess this, we evaluated the serum CGA levels in 189 patients with various pancreatic diseases, including proven pNETs (n=69), pancreatic cancer (PC) (n=50), chronic pancreatitis (CP) ...
Ahn Sun Young SY Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of - - 2014
New definitions and criteria were released at the Baveno V consensus meeting. The purposes of this study were to verify Baveno V definitions and criteria for failure to control bleeding and to determine the usefulness of combined use of the Adjusted Blood Requirement Index [ABRI: (number of blood units)/(final hematocrit-initial ...
Xu Wan-Ju WJ Department of Clinical Laboratory, Qianfoshan Hospital, Jingshi Road, No. 16766, Jinan, 250014, People's Republic of - - 2014
This study aimed to investigate the clinical values of serum alpha-fetoprotein-L3 (AFP-L3) and Golgi protein 73 (GP73) in the diagnosis of hepatocellular carcinoma (HCC) with low alpha-fetoprotein (AFP). From January 2011 to December 2013, 50 low-AFP HCC patients confirmed by the color Doppler flow imaging (CDFI) and pathological examinations were ...
Dellon Evan S ES 1] Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA [2] Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, - - 2014
The variability of eosinophilic infiltrates in eosinophilic esophagitis is not well described. This study aimed to determine the distribution of esophageal eosinophilia and the utility of histologic cut-points for eosinophilic esophagitis diagnosis in subjects undergoing endoscopy. We performed a prospective study of adults undergoing outpatient endoscopy. Research protocol esophageal biopsies ...
Kubota Kensuke K Division of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, 236-0004, Japan. - - 2014
Autoimmune pancreatitis (AIP) with cyst formation (ACF) is often refractory to corticosteroid treatment (CST). To determine the characteristic features for the development of ACF. We studied characteristics in AIP patients (n = 116) whether any factors might be related to ACF. Additionally, an individual database of 24 patients was compiled ...
De Iure Federico F Department of Spine Surgery, Ospedale Maggiore, Largo Nigrisoli 2, 40100, Bologna, Italy, - - 2014
To analyze the role of spine alignment in post-traumatic paraplegic patient as a potential cause of late Charcot spine disease (CSD). A retrospective review of three cases in which the disease appeared more than 15 years after a spinal cord injury treated by posterior fusion. A review of the literature concerning ...
Lee Ji Yeoun JY Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of - - 2014
Approximately 30 % of patients with moyamoya disease (MMD) have presented with involvement of the posterior circulation, mainly the posterior cerebral artery (PCA). Diagnosis of delayed progression of PCA stenosis in MMD may be difficult due to the diversity in clinical features. The goal of this study was to evaluate pediatric ...
Bakır M M Department of Infectious Diseases and Clinical Microbiology, Cumhuriyet University, School of Medicine, Sivas, 58140, Turkey, - - 2014
We aimed to validate a severity grading score (SGS) system for predicting the course of disease and fatality in Crimean-Congo hemorrhagic fever (CCHF). This SGS was established using several variables that were assumed to be associated with mortality and had clinical importance. We included patients diagnosed with CCHF from different ...
Cicone Francesco F Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy, - - 2014
Thyro-gastric autoimmunity has not been previously evaluated in patients with differentiated thyroid cancer (DTC), although its long-term complications may be relevant for the management of DTC patients. We assessed the prevalence of gastric autoimmunity and autoimmune gastritis (AG) in patients with Hashimoto's thyroiditis (HT) and concomitant DTC. Prevalence of parietal ...
Sato Hiroe - - 2014
Multiple sclerosis is a relatively rare disease, and complications of multiple sclerosis and rheumatoid arthritis are much rarer. Since anti-tumor necrosis factor therapy increases exacerbations of multiple sclerosis, complications of demyelinating diseases contraindicate anti-tumor necrosis factor therapy. There have been few reports of anti-interleukin-6 receptor therapy for patients with rheumatoid ...
Azizi Ghobad G G Azizi, Wilmington Endocrinology, Wilmington, 28403, United States - - 2014
Abstract Objective: This prospective study investigates the relationship between Hashimoto's Thyroiditis (HT) and thyroid cancer (TC) in patients with thyroid nodules (TNs). Methods: We prospectively examined 2100 patients with 2753 TNs between January 5, 2010 and August 15, 2013. A total of 2023 patients with 2669 TNs met the inclusion ...
Panorchan Kwanpeemai - - 2014
Cancer antigen 125 (CA125) is made by peritoneal mesothelial cells and can be measured in spent dialysate effluent from peritoneal dialysis (PD) patients. It has been suggested that CA125 is a marker of peritoneal mesothelial cell mass and turnover. As PD CA125 increases during peritoneal inflammation, we wished to determine ...
Hung Matthew M Department of Anaesthesia, Papworth Hospital, Cambridge, - - 2014
Preoperative anaemia is associated with increased morbidity and mortality. We sought to determine the relative frequencies of the different causes of anaemia including absolute and functional iron deficiency, and the association of different haematological parameters, including plasma hepcidin, a key protein responsible for iron regulation, with outcomes after cardiac surgery. ...
Hahn Andreas A Department of Psychiatry and - - 2014
Although previous investigations of transsexual people have focused on regional brain alterations, evaluations on a network level, especially those structural in nature, are largely missing. Therefore, we investigated the structural connectome of 23 female-to-male (FtM) and 21 male-to-female (MtF) transgender patients before hormone therapy as compared with 25 female and ...
Seril Darren N DN Departments of *Gastroenterology/Hepatology and †Colorectal Surgery, Digestive Disease Institute, the Cleveland Clinic Foundation, Cleveland, - - 2014
Clostridium difficile infection (CDI) is increasingly recognized in patients with ulcerative colitis with ileal pouch-anal anastomosis (IPAA). The aim of this study was to identify clinical risk factors for treatment-refractory or recurrent CDI in patients with IPAA. We identified patients with IPAA for underlying ulcerative colitis and a positive polymerase ...
Fellinger C C FAZ - Floridsdorf Allergy Centre, Vienna, - - 2014
The clinical relevance of elevated basal serum tryptase (eBST≥11.4ng/ml) often remains unclear. BST was assessed in 15,298 patients attending our outpatient clinic. Frequency and severity of anaphylaxis was compared in 900 patients with eBST and 900 patients with normal BST. The prevalence of eBST was evaluated in patients with drug ...
Kawate Hisaya H Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, - - 2014
Subclinical Cushing's syndrome (SCS) is characterized by subtle autonomous cortisol secretion from adrenal tumors without specific signs and symptoms of hypercortisolism. Patients with SCS have a high prevalence of "lifestyle-related diseases," such as hypertension, diabetes mellitus, dyslipidemia, and osteoporosis. Long-term follow-up of SCS patients is reportedly indispensable for establishing indications ...
Dogan Mutlu M Department of Medical Oncology, Ankara Numune Training and Research Hospital, 06100, Altindag, Ankara, Turkey, - - 2014
Malignant mesothelioma (MM) is a neoplasm which originates from serous membranes. It is relatively more common in Turkey. Ninety-nine patients between 2002-2009 were evaluated for survival and patient characteristics with chest pain, dyspnea, weight loss, loss of appetite, anemia, leukocytosis, thrombocytosis and lactate dehydrogenase (LDH) elevation, retrospectively. Male/female ratio was ...
Tsuboi Hiroto H Department of Internal Medicine, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki Prefecture , - - 2014
Objective. To assess the efficacy and safety of abatacept for secondary Sjögren's syndrome (SS) associated with rheumatoid arthritis (RA). Methods. The primary endpoint of this 1-year, open-labeled, prospective, observational multicenter study of RA-associated secondary SS was the rate of SDAI remission at 52 weeks after initiation of abatacept therapy. The ...
Suda Goki G Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Hokkaido, - - 2014
Telaprevir-based therapy for chronic hepatitis C patients is effective; however, the high prevalence of dermatological reactions is an outstanding issue. The mechanism and characteristics of such adverse reactions are unclear; moreover, predictive factors remain unknown. Granulysin was recently reported to be upregulated in the blisters of patients with Stevens-Johnson syndrome ...
Ruggieri Martino M Department of Educational Sciences, Chair of Paediatrics, University of Catania, Italy; Centre for Neurocutaneous Disorders, Department of Neurosciences, University of Catania, - - 2014
Spinal neurofibromatosis [SNF] is a related form of neurofibromatosis 1 [NF1], characterised by bilateral neurofibromas (histologically proven) of all spinal roots (and, eventually, of all the major peripheral nerve branches) with or without other manifestations of classical NF1. By rigorous application of these criteria to the 98 "SNF" cases published, ...
Okamoto Takayuki T Department of Nephrology, Oji Hospital , Tokyo , Japan - - 2014
Abstract Background: Intra-abdominal free air is found frequently in patients undergoing peritoneal dialysis (PD). Some studies have investigated an association between intra-abdominal free air and peritonitis in PD patients. However, most used chest X-rays, which are of limited sensitivity, and the association was not made clear. We conducted a retrospective ...
Müller Thomas T Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany, - - 2014
Repeated intrathecal application of the sustained release steroid triamcinolone acetonide is beneficial in progressive multiple sclerosis patients. Its putative regenerative effect may involve regulation of the repulsive guidance molecule A synthesis. This protein inhibits axonal regeneration and functional recovery. Objectives were to demonstrate the efficacy of four triamcinolone applications every ...
Rosario Pedro W PW Postgraduate Program and Endocrinology Service, Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Rua Domingos Vieira, 590, Santa Efigênia, Belo Horizonte, MG, 30150-240, Brazil, - - 2014
We evaluated the negative predictive value (NPV) of thyroglobulin obtained 24 h after the second recombinant human TSH (rhTSH) ampoule (Tg-D3), before ablation with (131)I, for persistent/recurrent disease (PRD) in low/intermediate risk patients with papillary thyroid carcinoma. One hundred and one patients with Tg-D3 ≤1 ng/ml without anti-Tg antibodies (TgAb) were selected. ...
Pitoia Fabián F División Endocrinología, Hospital de Clínicas, University of Buenos Aires, Córdoba 2351, 5th Floor, Buenos Aires, Argentina, - - 2014
The objective of this study was to evaluate the initial response to treatment and the long-term outcome of patients with papillary thyroid cancer (PTC), according to the modified 2014 risk of recurrence classification of the American Thyroid Association and the presence or absence of insulin resistance (IR). We retrospectively reviewed our ...
Kurtulmus Neslihan N Division of Internal Medicine, Department of Endocrinology, Faculty of Medicine, Acibadem University, Buyukdere Cad. No: 40, Maslak-Istanbul, Turkey, - - 2014
Langerhans cell histiocytosis (LCH) is a rare disease in which the most common endocrine manifestation is diabetes insipidus (DI). Data on anterior pituitary function in patients with LCH are limited. Thus, the present study investigated anterior pituitary function in LCH patients with DI via the evaluation of clinical and radiological ...
Piccione Ezequiel A EA Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA, - - 2014
Objective: To characterize autonomic impairment in motor neuron disease. Methods: Neurological evaluations and autonomic testing were analyzed retrospectively in 132 patients: 86 classic amyotrophic lateral sclerosis (ALS), 36 lower motor neuron disease (LMN), and 10 upper motor neuron predominant (UMN). Results: One-third of patients were symptomatic; urinary urgency and constipation ...
de Carvalho Fabricio Leite FL Division of Urology, University of Sao Paulo School of Medicine, Sao Paulo, - - 2014
We assessed the lower urinary tract symptoms (LUTS) and urodynamic findings in patients with neuromyelitis optica spectrum disorders (NMO-SD), a recently defined neurological disease. We prospectively evaluated seven men and 23 women (mean age 41.1 ± 13.5 years) with an established diagnosis of NMO-SD who were invited to participate irrespective of the ...
Orlacchio Antonio A Department of Diagnostic and Molecular Imaging, Radiation Therapy and Interventional Radiology, University Hospital Tor Vergata, Rome, Italy; Organ Transplantation Unit, University Hospital Tor Vergata, Rome, Italy. Electronic address: - - 2014
The aim of this study is to evaluate the usefulness of real-time elastography (RTE) in the diagnosis of graft interstitial fibrosis. We prospectively enrolled 50 patients clinically suspected of graft fibrosis. RTE was performed with a broadband linear transducer using a dedicated ultrasound machine. Tissue mean elasticity (TME) was calculated ...
Spektor Michael M Yale University School of Medicine, Department of Diagnostic Radiology, - - 2014
To describe laboratory and imaging findings associated with mortality in patients with gastric pneumatosis. Institution review board approval was obtained for this retrospective study. Using radiology report databases, all patients with "gastric pneumatosis" or "emphysematous gastritis" in their CT reports were identified from two institutions during 12 or 9 year ...
Chang Pei-Yeh PY Division of Pediatric Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan. Electronic address: - - 2014
We determined the chest height in a cohort of patients with primary spontaneous pneumothorax (PSP) who had received chest radiographic examinations prior to the attack. The aim of this study was to determine when their chest height began to change and how this was related to the PSP. From June ...
Fargo John H JH Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Md., - - 2014
Fanconi anemia (FA) is a rare inherited bone marrow failure syndrome (IBMFS). Affected individuals must be distinguished from relatives, patients with mosaicism must be identified, and patients with other IBMFS classified as non-FA. The diagnostic feature of FA is increased chromosomal breakage in blood lymphocytes cultured with diepoxybutane or mitomycin ...
Alroughani Raed R Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait, - - 2014
Using the MS registries in two MS clinics in Kuwait, we studied the demographics and clinical characteristics of multiple sclerosis (MS). Data of 736 patients (77.7% with relapsing remitting course) were analyzed. The mean age at onset and mean duration were 26.87 and 7.71 years, respectively. About 47.9% of patients ...
Pamuk Omer Nuri ON Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, - - 2014
Genetic polymorphisms of platelet endothelial cell adhesion molecule-1 (PECAM-1) were found to play roles in atherosclerotic events. We determined PECAM-1 polymorphisms, soluble PECAM-1, and CD40L levels in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and evaluated their associations with clinical atherosclerotic complications. We included 100 RA patients, 81 SLE ...
Tavano Francesca - - 2014
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated the expression of genes involved in gemcitabine uptake in a selected cohort of patients with PDAC, with well-defined clinical-pathological features.MethodsmRNA levels of hENT1, CHOP, MRP1 ...
Machaczka Maciej M Medical Faculty, University of Rzeszow, 35-959, Rzeszow, Poland, - - 2014
A viral contamination of the production plant producing imiglucerase (Cerezyme™) resulted in an unpredicted worldwide shortage of global supplies during 2009-2010. The aim of the study was to describe the effects of dose reduction of enzyme replacement therapy (ERT) in adults with Norrbottnian form of Gaucher disease type 3 (N-GD3). ...
Pinto Susana S Institute of Physiology and Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon , Lisbon , - - 2014
Clinical assessment of the respiratory function is critical in amyotrophic lateral sclerosis (ALS). A standardized process is to monitor the respiratory subscore of the revised ALSFRS (RofALSFRS-R). We tested the utility of RofALSFRS-R and its individual questions in evaluating respiratory functionality. Three hundred and fifty-seven consecutive ALS patients were assessed ...
Chan WengOnn W South Australian Institute of Ophthalmology and Discipline of Ophthalmology & Visual Sciences, University of Adelaide , Adelaide , Australia - - 2014
Abstract Purpose: The role of assisted local anaesthetic (aLA) for both endoscopic and external dacryocystorhinostomy is a well-tolerated and established approach. However the tolerability of aLA is unclear with powered burrs used in powered endoscopic DCR (PEDCR). We aim to evaluate the acceptability of aLA for PEDCR. Methods: This is ...
Koulaouzidis Anastasios A Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Scotland, United - - 2014
Esophageal capsule endoscopy (ECE) is considered to be an alternative to conventional esophagogastroduodenoscopy (EGD); however, its indications continue to expand. This report presents results from the use of ECE in patients with hemophilia at a tertiary referral academic center over a 7-year period. A total of 16 patients with hemophilia, ...
Lim Mi-Kyoung MK Division of Rheumatology, Department of Internal Medicine, Eulji University School of Medicine, 95 Dunsanseo-ro, Seo-gu, Daejeon, 302-799, South - - 2014
The aim of this study was to determine whether peptidyl arginine deiminase (PADI) genes could affect susceptibility to tuberculosis (TB), which can be a presumptive base to explain the increased incidence of TB in patients with rheumatoid arthritis (RA) in Korean. The study population consisted of 47 patients with active ...
Sadowski Krzysztof K Department of Neurology, Health Science Faculty, Warsaw Medical University, Kondratowicza 8, 03-242, Warsaw, Poland, - - 2014
Accumulating data confirm the usefulness of transcranial sonography (TCS) in the diagnosis of Parkinson's disease. The relevance of basal ganglia abnormalities depicted by TCS in atypical parkinsonian syndromes still needs further assessment. In the present study, 20 patients with progressive supranuclear palsy (PSP) and 13 patients with corticobasal syndrome (CBS) ...
Ehler Eric D ED Department of Radiation Oncology, University of Minnesota, MMC494, 420 Delaware Street SE, Minneapolis, MN 55455, - - 2014
The purpose of this study was to test the feasibility of a patient specific phantom for patient specific dosimetric verification.Using the head and neck region of an anthropomorphic phantom as a substitute for an actual patient, a soft-tissue equivalent model was constructed with the use of a 3D printer. Calculated ...
Pan Shan S School of Pharmacy, University of Otago, Dunedin, New - - 2014
Therapeutic drug monitoring in patients with rheumatoid arthritis (RA) receiving methotrexate (MTX, MTXGlu1) has not been established. In this study, we aim to explore the relationship between red blood cell (RBC) concentrations of MTX and its polyglutamate metabolites (MTXGlu n ; n = 2, 3, 4, 5) and clinical response in RA ...
Hall Andrew M AM Institute of Anatomy, University of Zurich, Zurich, - - 2014
We studied the extent and nature of renal involvement in a cohort of 117 adult patients with mitochondrial disease, by measuring urinary retinol-binding protein (RBP) and albumin; established markers of tubular and glomerular dysfunction, respectively. Seventy-five patients had the m.3243A>G mutation and the most frequent phenotypes within the entire cohort ...
Proft F F Division of Rheumatology and Clinical Immunology, Medical Clinic and Polyclinic IV, Ludwig-Maximilians-University Munich , Erlangen , - - 2014
Objectives: Recent findings suggest that autoimmune disorders predispose to a diminished capacity to taste and smell. This has been shown for patients with systemic lupus erythematosus as well as for patients with rheumatoid arthritis (RA). Granulomatosis with polyangiitis (GPA), with its particular manifestations in the upper respiratory tract, may therefore ...
Steinberg Benjamin A BA Duke Clinical Research Institute, PO Box 17969, NC 27715 Durham, NC, USA - - 2014
Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving oral anticoagulation. Patients randomized in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of ...
Misra U K UK Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, Uttar Pradesh, - - 2014
To evaluate the neurological manifestations of scrub typhus and correlate their clinical, EEG and MRI findings. A cross-sectional study over 2 years included patients with scrub typhus diagnosed by solid phase immunochromatographic assay or Weil-Felix test. A detailed clinical evaluation including Glasgow Coma Scale (GCS) was documented. Blood counts, chemistry, ECG, ...
Scirica Benjamin M BM TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA - - 2014
To determine the effect of ranolazine, an anti-ischaemic agent with anti-arrhythmic properties, on the overall burden of atrial fibrillation (AF) in acute coronary syndromes (ACS) and determine whether ranolazine reduces the long-term incidence of clinical AF after ACS. MERLIN-TIMI 36 randomized patients with non-ST elevation ACS to ranolazine or placebo. ...
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