Search Results
Results 601 - 650 of 2328
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Kaiser Ralf R Department of Internal Medicine, Saarland University Medical Centre, Homburg/Saar, - - 2014
In patients after the Fontan procedure, assessment of a failing Fontan circuit is difficult. Natriuretic peptides failed to be reliable markers of functional status or systemic ventricular function in this patient cohort. The aim of the study was to assess the clinical utility of mid-regional pro-adrenomedullin (MR-proADM) in patients after ...
Gao Liang L 1Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, 510080, - - 2014
Abstract To date, there are no definitive biomarkers for Parkinson's disease (PD) diagnosis. The detection of cerebrospinal fluid (CSF) alpha (α)-synuclein in PD patients has yielded promising but inconclusive results. To determine the performance of CSF α-synuclein as a diagnostic biomarker of PD and whether CSF α-synuclein can discriminate PD ...
Di Stefano Michele M 1st Department of Medicine, University of Pavia, IRCCS "S. Matteo" Hospital Foundation, Pavia, - - 2014
OBJECTIVES:Little information is available on the mechanisms responsible for dyspeptic symptoms in postprandial distress syndrome (PDS), characterized by the presence of prevalently meal-related early satiation and fullness, and the epigastric pain syndrome (EPS), characterized by the prominent symptom of epigastric pain, generally not meal related. In a group of PDS ...
Crestani E E Division of Immunology, Children's Hospital Boston, Boston, - - 2014
Glatiramer acetate (Copaxone) is a polymer of four amino acids and it closely resembles myelin basic protein. It is widely used as a disease-modifying agent with established efficacy in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS)(1) . Glatiramer acetate is usually dosed as a 1 mL subcutaneous daily ...
Francia Pietro P Division of Cardiology, Department of Clinical and Molecular Medicine, St. Andrea Hospital, Sapienza University, Rome, - - 2014
Hypertension entails atrial remodeling that affect P-wave (PW) duration on electrocardiogram (ECG). PW indices (e.g., variance, dispersion, and terminal force) are associated with a higher risk for atrial fibrillation (AF), but their calculation requires multiple measurements of PW duration, limiting their use in clinical practice. We evaluated whether PW duration ...
Hung Adriana M AM CSR&D, Veterans Administration Tennessee Valley Healthcare System, Nashville, TN, USA Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, - - 2014
Chronic systemic inflammation is common in patients with chronic kidney disease on dialysis (CKD5D) and has been considered a key mediator of the increased cardiovascular risk in this patient population. In this study, we tested the hypothesis that supplementation of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) will attenuate the systemic ...
Almeida David R P DR *Vitreoretinal Service, Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa; and †Department of Ophthalmology, Queen's University, Hotel Dieu Hospital, Kingston, - - 2014
To analyze the factors that may predict the release of vitreomacular traction (VMT) and vitreomacular adhesion. Retrospective case-control study of sixty-one patients with VMT imaged by optical coherence tomography over at least 3 months. Records from all patients seen at the University of Iowa from January 2012 to September 2013 ...
Turner Kevin K *Miraca Life Sciences Research Institute, Irving, Texas; and †Department of Medicine, Oregon Health & Sciences University, Portland, - - 2014
The relevance of granulomas in biopsy specimens from patients with Crohn's disease is largely unknown. Most previous studies have been performed on small samples and have produced conflicting results. This study was designed to compare the demographic, clinical, and histopathologic characteristics of a large cohort of documented patients with Crohn's ...
Wattjes Mike P MP Department of Radiology and Nuclear Medicine, MS Center Amsterdam, VU University Medical Center, Amsterdam, The - - 2014
To investigate the MRI manifestation pattern of asymptomatic natalizumab-associated progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis (MS). 18 patients with MS with natalizumab-associated PML lesions on MRI were included. In 6 patients, the PML lesions were identified on MRI prospectively and in 12 patients PML lesions were identified ...
Ramyead Avinash A University of Basel Psychiatric Clinics, Center for Gender Research and Early Detection, - - 2014
Converging evidence indicates that neural oscillations coordinate activity across brain areas, a process which is seemingly perturbed in schizophrenia. In particular, beta (13-30 Hz) and gamma (30-50 Hz) oscillations were repeatedly found to be disturbed in schizophrenia and linked to clinical symptoms. However, it remains unknown whether abnormalities in current ...
Cerasa Antonio A Neuroimaging Research Unit, IBFM-CNR, Germaneto, CZ, - - 2014
Pathological gambling (PG) is one of the most devastating non-motor complications of Parkinson's disease (PD). Neuroanatomical abnormalities in PD patients with PG are poorly understood. In the current study we investigated PD patients with and without PG using Voxel Based Morphometry (VBM) and local Gyrification Index (lGI), two neuroimaging techniques ...
Zellweger Michael J MJ Department of Cardiology, University Hospital, University of Basel, Basel, Switzerland. Electronic address: - - 2014
To evaluate prevalence, progression, treatment, and outcome of silent coronary artery disease (CAD) in asymptomatic patients with diabetes (DM) at high coronary risk. Despite the close association of diabetes and CAD, general CAD screening in asymptomatic patients with DM is discouraged even though outcome data in patients at high coronary ...
Cheng Fa-Juan FJ Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, - - 2014
Human neutrophil peptides (HNP) were recently implicated in the neutrophil extracellular trap (NET) complex, the impaired degradation of which has been associated with lupus nephritis (LN). Forty LN patients, 40 SLE patients without kidney injury, 63 immunoglobulin A nephropathy (IgAN) patients, 20 minimal change disease (MCD) patients and 33 healthy ...
Lewis Robert K RK Cardiac Electrophysiology Section, Duke Heart Center, Duke University Medical Center, Durham, North - - 2014
Preprocedural multidetector computed tomography (MDCT) may identify patients at risk for mechanical complications during lead extraction. To describe the use and feasibility of computed tomography scanning for preprocedural planning of lead extraction, we conducted a retrospective study of high-risk patients, who underwent electrocardiogram (ECG)-gated MDCT before planned lead extraction between ...
Jeong Hyemin H Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South - - 2014
To evaluate the clinical characteristics and outcomes of nonradiographic axial spondyloarthritis (nr-axSpA) in Korean patients. A retrospective analysis evaluated 155 patients with nr-axSpA at a single tertiary hospital between January 2001 and January 2011. Baseline characteristics and clinical courses were reviewed and compared with those of patients with ankylosing spondylitis ...
Li Xiuhui X From the 1 Department of Integrated TCM and Western Medicine, Beijing Youan Hospital affiliated with Capital Medical University , - - 2014
Background: Hand, foot, and mouth disease (HFMD) is a common infectious disease in children, characterized by acute viral infection accompanying acute inflammatory responses. Circulating histones are leading mediators of the inflammatory processes. This study aimed to elucidate whether circulating histones play a contributory role during HFMD. Methods: We measured plasma ...
Ong Bryan B From the *Division of Digestive and Liver Diseases, and the Department of Internal Medicine, University of Texas Southwestern Medical Center and Parkland Memorial Hospital, Dallas, TX; and †Department of Internal Medicine, Medical University of South Carolina, Charleston, - - 2014
Hemoglobin/hematocrit decreases in hospitalized patients without evidence of obvious gastrointestinal (GI) bleeding are common and often attributed to GI lesions. We hypothesized that inpatients with hematocrit declines without clinically overt GI bleeding have distinct clinical features and hence aimed to evaluate this clinical syndrome. We evaluated consecutive GI consults for ...
Chirico Valeria V Department of Pediatric Sciences, University of Messina, Messina, - - 2014
Endocrinopathies and metabolic disorders characterized β thalassemic (βT) patients and the prevention and treatment of these comorbidities are important targets to be achieved. The aim of the study was to analyse the diagnostic and prognostic role of ferritin for endocrinopathies and metabolic disorders in βT patients. Ability of iron chelators ...
Cavazzana Ilaria I Rheumatology and Clinical Immunology Unit, Spedali Civili di Brescia, Brescia, Italy. - - 2014
Aseptic meningitis is a rare and aggressive complication of rheumatoid arthritis (RA), usually histologically characterised by rheumatoid nodules and lymphocytic aggregates in leptomeninges. The aim of this study was to describe the clinical onset and evolution of aseptic meningitis occurring during anti-TNF-alpha (TNF-) therapy. we retrospectively analysed the clinical records ...
Dreimann Marc M 1Department of Trauma, Hand and Reconstructive Surgery, University Hospital Hamburg Eppendorf / Germany 2Department of Medical Psychology, University Hospital Hamburg Eppendorf, Germany 3Research Office, Biostatistics, Paracelsus Medical University, Salzburg / Austria 4German Scoliosis Center Bad Wildungen, Werner-Wicker-Klinik, Bad Wildungen / - - 2014
Study Design. This study examines the correlations between pulmonary function tests (PFTs) and radiographic measures of spinal deformities in scoliosis patients.Objective. To define the parameters that enable more accurate predictions of restricted PF in scoliosis patients.Summary of Background Data. The early identification of scoliosis patients who are at risk of ...
Adrie Christophe C 1Physiology department, Cochin Academic Hospital, Paris Descartes University, Sorbonne Cite, Paris, France 2Pasteur Institute, Cytokines & Inflammation Unit, Department of Infections and Epidemiology, Paris, France. 3Cardiac Surgery Department, Paris Saint-Joseph Hospital, Paris Descartes University, Paris, France 4Cardiac Surgery Department, Marie-Lannelongue Hospital, Le Plessis-Robinson, France 5Critical Care Unit, Melun General Hospital, Melun, - - 2014
To determine whether the good safety profile of transcatheter aortic valve implantation (TAVI) is related to lower levels of systemic bacterial translocation and systemic inflammation compared to open heart surgery. TAVI via the transfemoral approach is increasingly used in very high risk patients with aortic stenosis. The outcomes seem similar ...
Santangelo Roberto R Department of Neurology, San Raffaele Scientific Institute, Milan, - - 2014
Background: Three variants of primary progressive aphasia (PPA) have been currently characterized: non fluent/agrammatic (nfv-PPA), semantic (sv-PPA), and logopenic variant (lv-PPA). lv-PPA is most commonly associated with Alzheimer's disease (AD), while nfv-PPA and sv-PPA are related to frontotemporal lobar degeneration. Objective: We aimed to determine whether cerebrospinal fluid (CSF) amyloid-β42 ...
Ter Bekke Rachel M A RM Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The - - 2014
Prolonged and dispersed left-ventricular (LV) contraction is present in patients with long-QT syndrome (LQTS). Electrical and mechanical abnormalities appear most pronounced in symptomatic individuals. We focus on the 'electromechanical window' (EMW; duration of LV-mechanical systole minus QT interval) in patients with genotyped LQTS. Profound EMW negativity heralds torsades de pointes ...
Fijak Monika M Department of Anatomy and Cell Biology, Justus-Liebig University of Giessen, Aulweg 123, 35392 Giessen, Germany - - 2014
Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions? In sera from infertile azoospermic patients with histologically confirmed low-grade testicular inflammation, significantly elevated titers of autoantibodies against disulfide isomerase family A, member 3 (ER-60) were found. Infection and inflammation of the genital tract are supposed to be ...
Phan Kevin H KH Department of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA. Electronic address: - - 2014
Degenerative spondylolisthesis is a common pathological condition which leads to lumbar instability and significant clinical symptoms. The effect of this pathology on adjacent lumbar motion segments, however, has not yet been studied. The purpose of this study was to characterize the motion characteristics of lumbar degenerative spondylolisthesis at both the ...
Ozeki Michishige - - 2014
Expression and/or excretion of fibroblast growth factor-23 (FGF23) and its co-receptor Klotho are altered in patients with end-stage renal disease. The possibility that the FGF23/alpha-Klotho system mediates the aggravated cardiovascular outcome among patients with chronic kidney disease (CKD) has been suggested. We determined whether FGF23 and alpha-Klotho concentrations are altered ...
Cattrysse Fabienne - - 2014
Obstructive sleep apnea and hypopnea syndrome (OSAHS) is a disorder that causes clinical symptoms (e.g. snoring, excessive daytime sleepiness and impaired concentration) that may increase the risk of traffic accidents, cardiovascular disease, type 2 diabetes and reduce the quality of life. A recently developed device (Somnolter(R)) detects apneas and hypopneas ...
Bosello Silvia L SL Department of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, - - 2014
To assess the long-term efficacy and safety of single and multiple courses of rituximab therapy in systemic sclerosis (SSc) patients with and without lung disease. A total of 20 SSc patients with a diffuse disease were treated with rituximab. At baseline and during follow-up the lung involvement was evaluated with ...
Gazdag A A Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, P.O.B. 19, Debrecen, 4012, Hungary, - - 2014
The aim of this study was to investigate aortic stiffness and left ventricular (LV) systolic and diastolic function in patients with differentiated thyroid cancer (DTC) on thyroxine (L-T4) therapy and after L-T4 withdrawal to assess the cardiovascular impact of long-term subclinical hyperthyroidism and short-term overt hypothyroidism. Twenty-four patients who had ...
Shochat Michael M Heart Institute, Hillel Yaffe Medical Center, P.O. Box 169, 38100, Hadera, Israel, - - 2014
The instantaneous lung impedance (ILI) is one of the methods to assess pulmonary congestion or edema (PCE) in chronic heart failure (CHF) patients. Due to usually existing PCE in CHF patients when evaluated, baseline lung impedance (BLI) is unknown. Therefore, the relation of ILI to BLI is unknown. Our aim ...
Yanaba Koichi K Department of Dermatology, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-Ku, Tokyo, 105-8641, Japan, - - 2014
Obesity is thought to be involved in the pathogenesis of psoriasis, although its impact on the therapeutic response to systemic treatments remains unclear. The aim of this study was to examine the association of body mass index (BMI) with the efficacy of ustekinumab in Japanese patients with psoriasis. Clinical data ...
Honjo Hirotaka H Department of Surgery, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan, - - 2014
Intussusception is common in children but rare in adults. The goal of this study was to review retrospectively the symptoms, diagnosis, and treatment of intussusception in adults. From 1997 to 2013, we experienced 44 patients of intussusception in patients older than 18 years. The patients were divided into enteric, ileocolic, ileocecal, ...
Wu Chan C Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Road, DongCheng District, Beijing 100730, - - 2014
To investigate clinical characteristics of Purtscher-like retinopathy and its clinical implications among patients with systemic lupus erythematosus (SLE). Observational case series. Methods: SETTING: Tertiary medical center. Patients with SLE who were diagnosed with Purtscher-like retinopathy between 2002 and 2013. Assessment and follow-up in the ophthalmology department. Visual acuity and funduscopic ...
Holinski Franca F Department of Otorhinolaryngology, Head and Neck Surgery, University Medicine Berlin, Berlin, - - 2014
Background: Multiple sclerosis (MS) is a chronic disease characterized by CNS lesions causing physical and cognitive impairment. Using psychophysical testing, an olfactory disorder is diagnosed in 15-38.5% of patients with MS. Olfactometry permits objective testing of the sensory nerve function. Methods: The study looked at 20 patients with MS. Clinical, ...
Farrokhi Shawn S Human Movement Research Laboratory, Departments of Physical Therapy and Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: - - 2014
Coexisting patellofemoral osteoarthritis (PFOA) is a common finding in patients with tibiofemoral osteoarthritis (TFOA). The purpose of this study was to elucidate whether severity of coexisting PFOA in patients with TFOA is correlated with altered sagittal-plane gait biomechanics and greater knee-specific impairments. One hundred and six patients with radiographic TFOA ...
Vasseur Philippe P Department of Hepato-Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France; Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Pôle Biologie Santé, 86022 Poitiers, France. Electronic address: - - 2014
Pancreatic acinar cells are major targets of IL-22. Our aim is to study early plasma levels of IL-22, of pro- and anti-inflammatory cytokines in acute pancreatitis, and their association with severity or necrosis infection. Consecutive patients admitted to the Department of Hepato-Gastroenterology at Poitiers University of Medicine Hospital (France) with ...
Holt Edward W EW Department of Transplantation, Division of Hepatology, California Pacific Medical Center, San Francisco, CA. Electronic address: - - 2014
Oxidative stress is increased in patients with metabolic syndrome (MS). Antioxidants, including carotenoids, are decreased in MS. We hypothesized that a low skin carotenoid score (SCS), calculated using resonance Raman spectroscopy, would correlate with the presence of MS. We retrospectively reviewed consecutive patients referred for dietary assessment between 2010 and ...
Pesenti-Rossi D D Service de cardiologie, hôpital André-Mignot, Versailles hospital, 177, rue de Versailles, 78150 Le Chesnay, France; Department of cardiology, Ambroise-Paré clinic, 92200 Neuilly-sur-Seine, France. Electronic address: - - 2014
The purpose of the study was to assess whether a strategy based on a MDCT performed routinely before CA can reduce the radiation dose during the CA, without increased global exposure in patients who need imaging of CABG. A total of 147 consecutive patients were included. The radiation dose during ...
Yu Tao T Department of Critical Care Medicine, Nanjing Zhong-Da Hospital, Southeast University School of Medicine, Nanjing, - - 2014
Predicting fluid responsiveness is crucial for fluid administration in septic shock patients. Midazolam and propofol decrease vascular tone and venous return, which may influence preload dependency. However, little is known about the effects of these two sedatives on preload dependency in septic shock patients. We evaluated the effects of sedation ...
Westeneng Henk-Jan HJ Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The - - 2014
The aim of this study was to assess the involvement of deep gray matter, hippocampal subfields, and ventricular changes in patients with amyotrophic lateral sclerosis (ALS). A total of 112 ALS patients and 60 healthy subjects participated. High-resolution T1-weighted images were acquired using a 3T MRI scanner. Thirty-nine patients underwent ...
Allaix Marco E ME Center for Esophageal Diseases and Department of Surgery, Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 5031, Chicago, IL, 60637, USA, - - 2014
Esophageal epiphrenic diverticulum (ED) is usually secondary to a primary esophageal motility disorder, such as achalasia. Whereas the recommended surgical treatment includes esophageal myotomy and diverticulectomy, the outcome of patients in whom a myotomy without ED resection is performed is not known. The purpose of this study was to compare ...
Vanmassenhove J J Renal Division, Nephrology Section, 0K12, Ghent University Hospital, De Pintelaan 185, B9000, Ghent, Belgium, - - 2014
The pathophysiology of septic acute kidney injury (AKI) is incompletely understood, and there is controversy on the role of renal hypoperfusion in early sepsis. We hypothesized that renal hypoperfusion plays a role in early sepsis and that there is a continuum between transient AKI without tubular damage, transient AKI with ...
Zhao Jinxia J Department of Rheumatology & Immunology, Peking University Third Hospital, Beijing, 100191, China. - - 2014
To develop classification criteria for early rheumatoid arthritis (ERA) based on a large cohort of early inflammatory arthritis patients and to evaluate the performance of these criteria. The study population comprised a cohort of early inflammatory arthritis patients with symptom duration less than one year. Classification criteria of ERA were ...
Muratore Francesco F Division of Rheumatology, Department of Medicine, Arcispedale S. Maria Nuova IRCCS, Reggio Emilia, Italy, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, Division of Rheumatology, Department of Medicine, Division of Biostatistics, Department of Health Sciences Research and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, - - 2014
The aim of this study was to compare baseline variables, treatment and outcomes in patients with large-vessel GCA (LV-GCA), primarily of the upper extremities, with those with cranial disease (C-GCA). All patients >50 years of age with radiographic evidence of subclavian LV-GCA diagnosed between 1 January 1999 and 31 December ...
Venskutonyte Laura L Cardiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden - - 2014
Left ventricular diastolic dysfunction (LVDD) is considered to be common in patients with type 2 diabetes mellitus (T2DM), but information on its progression over time is lacking. We studied the longitudinal development of left ventricular diastolic function (LVDF) and myocardial blood flow reserve in patients with T2DM who were free ...
Gemel Joanna J Department of Pediatrics, University of Chicago, Chicago, IL, - - 2014
Normal atrial conduction requires similar abundances and homogeneous/overlapping distributions of two connexins (Cx40 and Cx43). The remodeling of myocyte connections and altered electrical conduction associated with atrial fibrillation (AF) likely involves perturbations of these connexins. We conducted a comprehensive series of experiments to examine the abundances and distributions of Cx40 ...
Bettini Luca L Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, - - 2014
Although long-term video-EEG monitoring (LVEM) is routinely used to investigate paroxysmal events, short-term video-EEG monitoring (SVEM) lasting <24h is increasingly recognized as a cost-effective tool. Since, however, relatively few studies addressed the yield of SVEM among different diagnostic groups, we undertook the present study to investigate this aspect. We retrospectively ...
Okanishi Tohru T Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, - - 2014
Multiple tubers in patients with tuberous sclerosis complex (TSC) often are responsible for drug-resistant epilepsy. The complexity of the epileptic network formed by multiple tubers complicates localization of the epileptogenic zone that is needed to design a surgical treatment strategy. High frequency oscillations (HFOs) on intracranial video-electroencephalography (IVEEG) may be ...
Lee Jun Ho JH Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Hallym University, Seoul, Republic of - - 2014
This clinical study was performed to analyze the characteristics of attic cholesteatoma occurring behind a tiny retraction of the pars flaccida, which was classified as Tos type I or II and had an intact pars tensa of the tympanic membrane. The clinical records of patients who underwent tympanomastoidectomy for attic ...
Akıl Eşref E Department of Neurology, Dicle University, Diyarbakir, Turkey. Electronic address: - - 2014
The role of epicardial fat thickness (EFT) in ischemic stroke (IS) has not been previously investigated. The aim of the present study was to evaluate EFT and neutrophil/lymphocyte ratio (NLR) among patients with IS and to examine the relationship between these inflammatory markers and the incidence of IS. The cross-sectional ...
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