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Results 601 - 650 of 3379
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Niedziela Jacek J Third Department of Cardiology, Silesian Center for Heart Diseases, Medical University of Silesia, M. Curie-Skłodowskiej 9, 41-800, Zabrze, Poland, - - 2014
In the general population, the lowest mortality risk is considered to be for the body mass index (BMI) range of 20-24.9 kg/m(2). In chronic diseases (chronic kidney disease, chronic heart failure or chronic obstructive pulmonary disease) the best survival is observed in overweight or obese patients. Recently above-mentioned phenomenon, called obesity ...
Shen Qi Q Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2014
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis. Due to the lack of unique surface markers expressed by neoplastic monocytes and the frequent CD34-negative blast immunophenotype, the diagnostic value of flow cytometric immunophenotyping (FCI) in CMML is rarely studied. In this study, by using a multicolor ...
Ozayar Asim A Department of Urology, University of Texas Southwestern Medical Center, Dallas, - - 2014
Equivocal uretero-pelvic junction obstruction (EqUPJO) refers to patients with clinical symptoms and/or other radiologic suggestion of possible UPJO, but with inconclusive results of obstruction on a diuretic renogram (DRG). We herein evaluate long-term outcomes of patients with EqUPJO who have undergone minimally invasive pyeloplasty (MIP). We performed a retrospective analysis ...
Buttini S S 1] Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale 'Amedeo Avogadro', Novara, Italy [2] Department of Translational Medicine, Section of Neurology, University of Piemonte Orientale 'Amedeo Avogadro', Novara, - - 2014
Perforin (PRF) has a key role in the function of cytotoxic T and natural killer cells. Rare variations of PRF1 predispose to autoimmunity. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, involving defective lymphocyte apoptosis. The aim of this study was to investigate the ...
Wada Mayumi M Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, North 13, West 7, Kita-ku, Sapporo, 060-8586, Japan, - - 2014
We describe two patients with anti-BP180-type mucous membrane pemphigoid (MMP), who were correctly diagnosed and treated in early stages through the cooperation of dentists and dermatologists. Patient 1 was a 74-year-old woman who visited our dental department due to blisters over the oral mucosa and eruptions on the skin. She ...
Li Li L Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, - - 2014
To study the role of brain responses to thermal stimulation in outcome prediction of patients in either vegetative or minimally conscious states. We performed a prospective study with 22 patients and used functional magnetic resonance imaging (fMRI) and EEG reactivity (EEG-R) tests in conjunction with thermal stimulation. We conducted thermal ...
Forel Jean-Marie JM Faculté de Médecine, Aix-Marseille Université, URMITE UMR CNRS 7278, 13005, Marseille, France, - - 2014
A specific biomarker of post-ARDS fibroproliferation could be useful in the identification of patients who could benefit from therapies aiming to modulate fibroproliferation such as corticosteroids.The aim of this prospective study was to determine the best threshold of the N-terminal-peptidetype III procollagen (NT-PCP-III) in non-resolving ARDS to validate this threshold ...
Aarli Bernt B BB Institute of Clinical Science, University of Bergen, Bergen, Norway Dept of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway - - 2014
The forced oscillation technique can identify expiratory flow limitation (EFL) when a large difference in inspiratory and expiratory reactance (ΔXrs) occurs. However, flow limitation can vary from breath to breath, and so we compared a multiple-breath ΔXrs approach to the traditional breath-by-breath assessment of EFL. We investigated the within- and ...
Tateno Fuyuki F Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, - - 2014
Dementia with Lewy bodies (DLB) is the second most common degenerative cause of dementia, whereas lower urinary tract (LUT) function in DLB patients has not been fully delineated. We investigated LUT function in DLB by clinical-urodynamic observations. We examined 32 patients with DLB (23 men, 9 women; aged 59-86 [mean, ...
Lightfoot Andrew J AJ University of Pennsylvania, Urology, Philadelphia, Pennsylvania, United States ; - - 2014
INTRODUCTION We analyzed the trends of positive surgical margin (PSM) location in patients that had pT3 disease at robotic assisted radical prostatectomy (RARP). We aimed to describe our changing incidence of positive surgical margins in the largest series to date of patients with pT3 disease treated by RARP. METHODS A ...
Barry J A JA Institute for Women's Health, University College London Medical School , London , - - 2014
The aim of this systematic review and meta-analysis was to assess any difference in the self-ratings of hostility in mentally healthy women with different levels of prolactin (PRL). Electronic databases (PubMed, MEDLINE, EMBASE and the Cochrane Library) were searched up to 2nd July 2012 for published literature comparing hostility levels ...
Higashihara Eiji E Department of ADPKD Research, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan, - - 2014
The total kidney volume (TKV) and total liver volume (TLV) increase and renal function decreases progressively in patients with autosomal dominant polycystic kidney disease (ADPKD). Somatostatin analogues, such as octreotide, reduce these increases in TKV and TLV. The aim of this study was to examine the safety of the short-term ...
Okada S S Department of Paediatrics, Yamaguchi University Graduate School of Medicine , Ube , - - 2014
Objectives: To establish the optimal inflammation control of Kawasaki disease (KD), we investigated the clinical and pathophysiological basis of pericardial effusion (PE) during the acute phase of KD. Method: Clinical and laboratory features of Japanese KD children with PE (PE group: n = 9) and without PE (non-PE group: n ...
Szmigielska-Kaplon Anna A Department of Hematology, Medical University of Lodz, Lodz, - - 2014
The bone marrow niche functions are modulated by complicated cytokines network. The aim of our study was to evaluate the levels of VCAM-1, VEGF, MMP-9 and SDF during mobilization of CD34+ cells in patients with hematological malignancies. Thirty four patients were enrolled to the study (19F, 15 M) at median ...
Pohlhammer Johannes J Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, - - 2014
Background. Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. Methods. Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent claudication and 249 age- ...
Tavares E Castro A A Pulmonology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal. Electronic address: - - 2014
International guidelines define significant bronchodilator response as absolute and percentage change from baseline in forced expiratory volume (FEV1) in the first second and/or forced vital capacity (FVC) ≥12% and 200mL. However, bronchodilator effects on other lung function parameters have also been correlated to some degree of reversible airflow limitation. To ...
Kurt Semiha S Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Neurology, Gaziosmanpasa University Faculty of Medicine, Tokat, - - 2014
Objectives: We did a retrospective analysis of the clinical, pathological, and electrophysiological features of 21 cases of asymptomatic vasculitic neuropathy (AsVN). Methods: Among 270 patients with biopsy proven vasculitic neuropathy, we identified 21 (7.8%) who had asymptomatic neuropathy. Results: Of the 21 patients with AsVN, 11 were women and 10 ...
de Havenon Adam A From the Department of Neurology (A.d.H.), University of Washington, Seattle; and the Departments of Ophthalmology (Z.J., K.D.), Radiology (L.L., L.S.), and Neurology (S.A., K.D.), University of Utah, Salt Lake City. - - 2014
To characterize a cohort of patients with the signs and symptoms of posterior reversible encephalopathy syndrome (PRES), but with clinical and radiologic involvement of the spinal cord. We report 2 cases of PRES with spinal cord involvement and identified an additional 6 cases in the Medline database using various search ...
Giossi Alessia A From the U.O. Neurologia (A.G.), Istituto Clinico S. Anna, Brescia; Dipartimento di Scienze Cliniche e Sperimentali (P.C., A.M., L.P., I.V., V.D.G., A. Padovani, A. Pezzini), Clinica Neurologica, Università degli Studi di Brescia; U.O. di Recupero e Rieducazione Funzionale (E.D.Z.), IRCCS Fondazione Don Gnocchi, Milano; Stroke Unit (M.G.), Neurologia Vascolare, Spedali Civili di Brescia; U.O. Neurologia (P.B., G.T., M. Carletti), Azienda Ospedaliera-Universitaria Borgo Trento, Verona; U.O.C. Neurologia (N. Checcarelli), Ospedale Valduce, Como; Dipartimento di Neuroscienze (G.M.), Università di Padova; U.O.C. Neurologia (M.M.), Ospedale di Arzignano; S.O.C. Neurologia (M. Chinaglia), Ospedale di Rovigo; and Sezione di Biologia e Genetica (M.R., N. Chiarelli, M. Colombi), Dipartimento di Medicina Molecolare e Traslazionale, Università degli Studi di Brescia, - - 2014
To investigate the prevalence of connective tissue abnormalities in patients with spontaneous cervical artery dissections (sCeAD). We systematically assessed clinically detectable signs of connective tissue aberration in a series of consecutive patients with sCeAD and of age- and sex-matched patients with ischemic stroke unrelated to CeAD (non-CeAD IS) by a ...
Jiang Huanhuan H Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the First Hospital Affiliated to Anhui Medical University, Hefei, - - 2014
Chronic inflammation is considered to be one of the hallmarks for tumor initiation and progression. Moreover, a long-term production and accumulation of inflammatory factors leads to a local and systemic immunosuppression associated with cancer progression. However, the correlation between inflammatory mediators, immunosuppressive cells and the clinical outcome of malignant melanoma ...
Both Tim T Division of Clinical Immunology and Division of Nephrology and Transplantation, Department of Internal Medicine and Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands. - - 2014
Our objectives were to analyse the prevalence of distal renal tubular acidosis (dRTA) in primary SS (pSS) and to compare a novel urinary acidification test with furosemide and fludrocortisone (FF) with the gold standard ammonium chloride (NH4Cl) to detect dRTA. Urinary acidification was assessed in 57 pSS patients using NH4Cl ...
Faye Elodie E VariaPsy, Variability of the Response to Psychotropic Drugs, Paris Descartes and Paris Diderot Universities, Paris, France; Unit of Therapeutic Research, Department of Internal Medicine, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, - - 2014
This study aimed to determine whether short small intestine modifies antidepressant concentrations. The Css values and concentration-dose ratios (CDRs) of citalopram or escitalopram, administered orally or intravenously, were determined in patients with short bowel syndrome. Eight patients (6 males and 2 females) were included in the study. High CDRs were ...
Navaneethan Udayakumar U Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH, USA - - 2014
The comparative outcomes of ulcerative colitis (UC) and Crohn's disease (CD) in patients with primary sclerosing cholangitis (PSC) are unclear; the aim of our study was to make an objective comparison. A total of 273 patients with PSC and inflammatory bowel disease (223 with UC and 50 with CD) were ...
Molitch Mark E ME Martha Leland Sherwin Professor of Endocrinology, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: - - 2014
If treatment of Cushing's disease (CD) by surgery is not successful, medical therapy is often required. Long-term use of metyrapone is limited by hirsutism and hypertension and escape because of increased ACTH levels. Although ketoconazole can normalize cortisol levels in 50%, liver toxicity limits its use. Mitotane, an adrenolytic agent, ...
Davila Carlos D CD Department of Medicine, Einstein Medical Center , Philadelphia, PA , USA - - 2014
Abstract The effectiveness of aspirin and clopidogrel in patients with chronic kidney disease (CKD) suffering from acute cardiovascular events is unclear. High on treatment platelet reactivity (HTPR) has been associated with worse outcomes. Here, we assessed the association of dipstick proteinuria (DP) and renal function on HTPR and clinical outcomes. ...
Kang Ky K Division of Rheumatology, Department of Internal Medicine, Incheon St Mary's Hospital, The Catholic University of Korea , Incheon , South - - 2014
Objectives: The formation of spinal syndesmophytes is an important outcome measure in ankylosing spondylitis (AS) but the predictors of new syndesmophyte development in female AS patients are unknown. This longitudinal study aimed to assess the rate and predictors of development of new syndesmophytes over a 2-year period in female AS ...
Grygorczuk Sambor S Medical University in Białystok, Department of the Infectious Diseases and Neuroinfections, ul. Żurawia 14, 15-540 Białystok, Poland. Electronic address: - - 2014
Tick-borne encephalitis (TBE) has a wide clinical spectrum, from asymptomatic to severe encephalitis, and host-dependent factors determining the outcome remain elusive. We have measured concentrations of pro-inflammatory/Th1 interferon-γ (IFNγ), immunomodulatory/Th2 interleukin-10 (IL-10), anti-viral type I (IFNβ) and type III (IFNλ3) interferons in cerebrospinal fluid (csf) and serum of 18 TBE ...
Kim Yong Kyun YK Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Goyang, South - - 2014
In dementia patients, a deficit in activities of daily living (ADL) is one of the main problems. Our objective was to assess ADL using the Korean Modified Barthel Index (K-MBI) in patients with Alzheimer's disease (AD) plus cerebrovascular disease (CVD) treated with a rivastigmine patch for 24 weeks in an ...
Cao Chun C Department of Hematology, Key Lab of Hematology of Sichuan Province, West China Hospital, Sichuan University, Chengdu, - - 2014
The human organic cation transporter 1 (hOCT1) is the major active influx protein responsible for the transport of imatinib mesylate (IM) into cells. Previous studies have used (14)C-labeled IM to demonstrate a link between chronic myeloid leukemia (CML) molecular response and hOCT1 activity. However, this method is not convenient in ...
Jin Jianmin - - 2014
BackgroundAllergy and Aspergillus hypersensitivity (AH) were shown to be associated with severe symptoms or worse lung function in COPD patients. The prevalence of elevated total IgE (T-IgE) and its association with clinical symptoms and lung function in COPD have not been studied. The prevalence of AH and its correlation with ...
Caria Stefania - - 2014
Infrequent dialysis, namely once-a-week session combined with very low-protein, low-phosphorus diet supplemented with ketoacids was reported as a useful treatment schedule for ESRD patients with markedly reduced residual renal function but preserved urine output. This study reports our findings from the application of a weekly dialysis schedule plus less severe ...
Kohno Shigeru S Department of Respiratory Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: - - 2014
To clarify the clinical features of pulmonary cryptococcosis in Japanese non-HIV population. Retrospective investigation of 151 pulmonary cryptococcosis cases between 1977 and 2012 was executed. The underlying disease (UDs), aggravating factors, radiological characteristics, and treatment were examined. Sixty-seven patients (44.4%) had no UDs. The common UDs were diabetes (32.1%) followed ...
Williamson John B JB a Malcom Randall VAMC , Gainesville , FL , - - 2014
Objective: This was to learn how chronic right hemispheric damage (RHD) versus left hemispheric damage (LHD) may influence attentional biases in proximal and distal space. Background: Prior research has suggested that the left hemisphere primarily attends to proximal space and the right hemisphere to distal space. The purpose of this ...
Han Cong C Department of Neurosurgery, 307 Hospital, PLA, 8 Dong-Da Street, Fengtai District, Beijing 100071, - - 2014
Moyamoya syndrome (MMS) associated with neurofibromatosis type 1 (NF1) has rarely been reported anywhere in the world, particularly in Asia. Because of the rarity of this disorder, its natural history, clinical symptoms, management, and follow-up findings remain unclear. The objective of this study was to evaluate the clinical presentation, neurological ...
Batla Amit A Sobell Department of Motor Neuroscience and Movement disorders, UCL Institute of Neurology, London, United - - 2014
We previously reported on a cohort of dystonic tremor and patients with scans without evidence of dopaminergic deficit (SWEDDs). We aim to report the long-term clinical and imaging follow-up of these patients. Patients with at least 5-year follow-up were included. These patients had an asymmetric arm tremor, a previous diagnosis ...
Yang Xiao-Jun XJ Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, - - 2014
To investigate the feasibility and safety of pH capsule to monitor pH in patients with gastroesophageal reflux disease (GERD). Ninety-one patients with symptoms suggestive of GERD were enrolled in this study, 46 of whom were randomized to the pH capsule group; the remaining 45 patients used the conventional catheter and ...
Edson-Heredia E E Eli Lilly and Company, Indianapolis, - - 2014
Previous studies have demonstrated that patients with psoriasis have higher rates of comorbidities compared to the general population. Despite the clinical and economic burden of psoriatic disease, there have been few large-scale observational studies focused on this condition. To assess rates of cardiovascular, autoimmune, infectious and other conditions in patients ...
Freeman Jennifer J JJ Section of Pediatric Surgery, Department of Surgery, University of Michigan Health System, Mott Children's Hospital, 1540 E. Hospital Dr., SPC 4211, Ann Arbor, MI, 48109-4211, USA, - - 2014
To report a previously poorly recognized process of secondary formation of inflammatory bowel disease (IBD)-like process, specifically Crohn's-like changes in pediatric surgery patients who underwent major small bowel and colorectal surgery. We describe potential etiologies, presenting symptoms and treatment approaches. Retrospective chart review of patients with history of either chronic, ...
Banwait Ranjit R Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, - - 2014
Disease assessment in Waldenstrom Macroglobulinemia (WM) is dependent on the percent involvement of B-cell neoplasm in the bone marrow and IgM paraprotein in the serum. A subset of patients also demonstrates extramedullary involvement, which is infrequently examined. The role of extramedullary involvement in the diagnosis and prognosis of WM is ...
Ly Mohamedou M Department of Congenital Heart Disease, Marie Lannelongue Hospital/M3C, Paris-Sud University, Le Plessis-Robinson, France. Electronic address: - - 2014
Uncommonly, adults with functionally univentricular hearts are becoming candidates for a Fontan procedure. The purpose of this study was to evaluate the course of patients undergoing the modified Fontan procedure with an extracardiac conduit in recent years. Between January 2003 and December 2013, 32 adult patients (17 female and 15 ...
Cachia David D Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, - - 2014
Cryptococcal meningitis is the most common manifestation of cryptococcosis and is caused by the encapsulated yeast organism Cryptococcus neoformans. It occurs most commonly in patients with impaired cell-mediated immunity such as in HIV infection; patients with hematological malignancies; patients post solid-organ transplantation; on chronic steroids or immunosuppressants. Clinically, stroke can ...
Lin Chin-Yao CY Division of Nephrology, Department of Internal Medicine, Taiwan Adventist Hospital , Taipei , Taiwan - - 2014
Abstract Background: The ankle-brachial index (ABI) is associated with peripheral vascular atherosclerosis, adverse cardiovascular outcomes, and all-cause mortality. However, there were limited data available on studying the effect of interleg ABI difference. Methods: We investigated the association of the interleg ABI difference with overall and cardiovascular mortality in chronic hemodialysis ...
Wong Grace Lai-Hung GL Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, - - 2014
Vitamin D is an immunomodulator that might be involved in the pathogenesis of viral hepatitis. We investigated the effects of vitamin D deficiency on long-term outcomes of patients with chronic hepatitis B (CHB). We performed a prospective cohort study of 426 patients with CHB (65% male; mean age, 41 ± 13 years), ...
Biyik Murat M 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey; 2Nephrology Clinic, Karaman State Hospital, Karaman, Turkey; 3Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey; and 4Gastroenterology Clinic, Karaman State Hospital, Karaman, - - 2014
Proton pump inhibitors (PPIs) are extensively prescribed drugs usually used for a long period. Recent reports linked PPI use with development of hypomagnesemia. However, there is still uncertainty regarding risk of hypomagnesemia in outpatients who were on long-term PPI use. Thus, we aimed to evaluate frequency of hypomagnesemia among a ...
Koo Soo Kweon SK Department of Otorhinolaryngology, Busan Saint Mary's Medical Center, Pusan, South Korea, - - 2014
The objective of the study was to determine the effect of the maxillary sinus on the voice. The prospective study was conducted at an academic secondary referral center. A prospective chart review of 43 patients (17 males, 26 females) who conducted a voice recording and survey before and 3 months after ...
Mahfouz R R Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, - - 2014
Contact of peripheral blood lymphocytes with Helicobacter pylori was proved to induce non- major histocompatibility complex-restricted cytotoxicity and natural killer cells are thought to play an important role in the immunity against H. pylori. In this research, we investigated any possible association between killer immunoglobulin-like receptors (KIR) genotypes and H. ...
Han Jinu J http://orcid.org/0000-0002-8607-6625 Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, - - 2014
To describe the ophthalmological manifestations in patients with childhood onset Leigh syndrome (LS) and investigate the correlation between genotypes and phenotypes in patients with LS. Childhood onset LS was clinically and enzymatically confirmed in a total of 63 patients. Among them, 44 patients who underwent ophthalmologic consultation were included in ...
Genovesi Simonetta S Department of Health Science, University of Milano-Bicocca, Monza, Italy Nephrology Unit, San Gerardo Hospital, Monza, - - 2014
Oral anticoagulation therapy (OAT) is the choice treatment for thromboembolism prevention in atrial fibrillation (AF), although data about OAT use in haemodialysis (HD) patients with AF are contradictory. The effect of OAT on the risk of mortality, stroke and bleeding was prospectively evaluated in a population of HD patients with ...
Yu Ai-Ping AP Department of Inpatient, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, PR - - 2014
The purpose of this study was to observe the treatment response of anti-neutrophil cytoplasmic antibody (ANCA)-associated pulmonary interstitial fibrosis in 8 patients before and after glucocorticoid or immunosuppressive therapy. The clinical features and computed tomography imaging findings of the 8 patients in our hospital from October 2011 to October 2013, ...
Abe Tomoko T Department of Nephrology, Nagoya University Graduate School of Medicine, 65, Tsuruma-cho, Showa-ku, Nagoya, Aichi, 464-8550, - - 2014
Previous studies have suggested that high neutrophil/lymphocyte ratios are related to worse outcome in patients with cardiovascular diseases. Patients with end-stage renal disease, especially those with inflammation, are at an increased risk of premature mortality, primarily because of cardiovascular disease. We aimed to clarify if high neutrophil/lymphocyte ratio is associated ...
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