Search Results
Results 551 - 600 of 2840
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Karageorgiadis Alexander S AS Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, - - 2014
Context: Ectopic ACTH/CRH syndrome is a rare cause of Cushing syndrome (CS), especially in children. The localization, work-up, and management of ACTH/CRH secreting tumors are discussed. Setting: A retrospective study was conducted of patients under 21 years of age evaluated at the National Institutes of Health (NIH) for CS and ...
Roziakova Lubica L Department of Haematology and Transfusion Medicine, University Hospital and Comenius University, Bratislava, Slovak - - 2014
The long-term prognosis of patients after haematopoietic stem cell transplantation (HSCT) has greatly improved. Cardiac complications represent unresolved and potentially life-threatening conditions in these patients. We prospectively examined 37 consecutive patients with a median age of 28 years who underwent allogeneic HSCT. Biomarkers of cardiac injury were measured serially before the ...
Duong J K JK School of Medical Sciences, University of New South Wales, Kensington, Australia; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst, - - 2014
To compare the pharmacokinetics of metformin between diabetic Indigenous (Aboriginal and Torres Strait Islander) and non-Indigenous patients. An observational, cross-sectional study was conducted on type 2 diabetic Indigenous and non-Indigenous patients treated with metformin. Blood samples were collected to determine metformin, lactate, creatinine and vitamin B12 concentrations and glycosylated haemoglobin ...
Valois Aude A Dermatology and Allergy, University Hospital of Nancy, rue du Morvan 54511, Vandoeuvre-les-Nancy, - - 2014
Modern dressings (MDs) may have a low sensitization rate, but there is a lack of prospective studies in patients with chronic leg ulcers (CLUs) to evaluate this. To determine the rate of sensitization (contact allergy) to MDs and substances present in dressings. A prospective multicentre study was carried out in ...
Lebedeva E R ER Department of Neurology and Neurosurgery, the Urals State Medical University, Yekaterinburg, Russia; International Headache Center "Europe-Asia", Yekaterinburg, - - 2014
Unruptured saccular intracranial aneurysm (SIA) is associated with an increased prevalence of migraine, but it is unclear whether this is altered by clipping of the aneurysm. The aim of our study was to determine whether remission rate of migraine and other recurrent headaches was greater in patients with SIA after ...
Edwards Adam L AL Tinsley Harrison Internal Medicine Residency Program, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, - - 2014
Obscure overt gastrointestinal bleeding (OGIB) is a challenge in patients with left ventricular assist devices (LVADs). We evaluated the utility and safety of double-balloon enteroscopy (DBE) in patients with LVADs in an observational consecutive-patient cohort from a single tertiary referral center. Ten patients with LVADs underwent thirteen DBEs for obscure ...
Merkerova Michaela Dostalova MD Institute of Hematology and Blood Transfusion, Prague, Czech - - 2014
Lenalidomide is a potent drug with pleiotropic effects in patients with myelodysplastic syndrome (MDS) with deletion of the long arm of chromosome 5 [del(5q)]. We investigated its effect on regulation of microRNA (miRNA) expression profiles in del(5q) MDS patients in vivo. We used miRNA expression microarrays to study changes in ...
Rumbolt Colin B C CB Physical Medicine and Rehabilitation, University of Manitoba, Faculty of Medicine; Riverview Health Centre: Neuromuscular and Electrodiagnostic - - 2014
Introduction: In patients with clinically diagnosed CTS the more symptomatic hand may be different from the more severely affected hand on electrodiagnostic testing. This study aims to determine the level of agreement which should be expected between these measures and consequently the level of suspicion for co-occurring pathology which is ...
Mahmarian John J JJ Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist, 6550 Fannin Street, Suite 677, Houston, TX, 77030, USA, - - 2014
Total and reversible left ventricular (LV) perfusion defect size (PDS) predict patient outcome. Limited data exist as to whether regadenoson induces similar perfusion abnormalities as observed with adenosine. We sought to determine whether regadenoson induces a similar LV PDS as seen with adenosine across varying patient populations. ADVANCE MPI were ...
Akıl Eşref E Department of Neurology, Faculty of Medicine, Dicle University, 21280, Diyarbakir, Turkey, - - 2014
The role of carcinoembryonic antigen (CEA) in Parkinson's disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients with Parkinson's disease and to examine the relationship between these ...
Bektaş Omer O Department of Pediatric Neurology, Ankara University Medical School, Ankara, - - 2014
Our aim was to determine the presence and possible role of autoantibodies in epileptic patients with an undetermined etiology. Eighty epilepsy patients, who were referred to the Pediatric Neurology Department at Ankara University between November 2011 and April 2012, were enrolled in the study. Antinuclear antibodies (ANA), anticardiolipin IgG, antiphospholipid, ...
Gui Y Y Department of Anesthesiology, The First Affiliated Hospital of Nanhua University, Hengyang, - - 2014
Study design:Prospective, randomized and controlled study.Objectives:The aim of the study was to investigate the effect of intermittent normobaric hyperoxia (InHO) for treatment of neuropathic pain in patients with spinal cord injury (SCI).Setting:The First Affiliated Hospital of Nanhua University, Hengyang, Hunan Province, China.Methods:Patients with SCI from Hunan Province were recruited from ...
Ye Xuan X Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia; Department of Surgery, Prince of Wales Hospital, Sydney, New South Wales, - - 2014
To determine the relative likelihood of upper limb venous thrombosis (ULVT) in patients with peripherally inserted central catheter (PICC) versus central venous catheter (CVC), compared with patients without a catheter, in a tertiary hospital setting. Retrospective review of all upper limb venous duplex ultrasounds performed for the investigation of venous ...
Moccia M M Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, - - 2014
Diagnosing Parkinson's disease (PD) and tracking its progression may require the combination of reliable biomarkers. Among them, both serum uric acid (UA) and dopamine transporter (DaT) binding deserve more investigations. We aimed to investigate the relationship between serum UA levels and DaT availability in newly diagnosed, drug-naïve PD patients, by ...
Peteghem Sylvie Van - - 2014
Cerebral pathology is frequently encountered post heart transplantation with a cumulative incidence of about 80% after 15 years. A broad spectrum of disease entities is reported, from minor abnormalities to life-threatening diseases. Although cerebral infections and malignancies are rare in this patient population, they have a high mortality rate. Since ...
Sakthiswary Rajalingham R Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, - - 2014
The main objective of this study is to elucidate the role of immunoglobulin A (IgA) rheumatoid factor (RF) in predicting the clinical response to tumour necrosis factor α inhibitors (TNFi) among patients with rheumatoid arthritis (RA). We recruited all patients with RA who were ever on TNFi for a minimum ...
Krishnamurthy Venkat V Department of Surgery, University of Michigan, - - 2014
Given the very ill nature of patients with critical limb ischemia (CLI), the use of percutaneous vascular interventions (PVIs) for limb salvage may or may not be efficacious; in particular, for those with polyvascular arterial disease. Herein, we reviewed large, multi-institutional outcomes of PVI in polyvascular and peripheral arterial disease ...
Janeiro Dario D Nephrology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain - - 2014
♦ Background: Autosomal dominant polycystic kidney disease (ADPKD) has been considered a relative contraindication for peritoneal dialysis (PD), although there are few specific studies available. ♦ Methods: A multicenter historical prospective matched-cohort study was conducted to describe the outcome of ADPKD patients who have chosen PD. All ADPKD patients starting ...
Wallentin Lars L Uppsala University, Uppsala, Sweden - - 2014
-Growth Differentiation Factor 15 (GDF-15), high sensitivity troponin and NT-proBNP levels are predictive of death and cardiovascular events in healthy elderly subjects, patients with acute coronary syndrome and heart failure. Hs-TnI and NT-proBNP are also prognostic in patients with atrial fibrillation. We evaluated the prognostic value of GDF-15 alone and ...
Vijayakumar Ramya R Washington University in St. Louis, Saint Louis, - - 2014
-Congenital Long QT syndrome (LQTS) is an arrhythmogenic disorder that causes syncope and sudden death. While its genetic basis has become well-understood, the mechanisms whereby mutations translate to arrhythmia susceptibility in the in situ human heart have not been fully defined. We used noninvasive ECG imaging (ECGI) to map the ...
Rizzo Jennifer L JL Department of Ophthalmology and Vision Science (JLR, KVL, JLK), University of California Davis Eye Center, Sacramento, California; Departments of Neurology and Ophthalmology and Visual Sciences (MW), University of Iowa, Iowa City, Iowa; Department of Public Health, Clinical and Translational Science Center (MDW), University of California Davis, Davis, California; and Departments of Neurology and Neurological Surgery (JLK), University of California Davis, Sacramento, - - 2014
To investigate the effect of cerebrospinal fluid (CSF) shunting on quantitative perimetry and papilledema in patients with uncontrolled idiopathic intracranial hypertension (IIH). We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 2011. Perimetry was performed before and after surgery in 15 patients, and ...
Lorenzen Johan M JM Institute of Molecular and Translational Therapeutic Strategies (IMTTS) and Department of Medicine/Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; - - 2014
Long noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating gene expression. Intriguingly, these RNA transcripts are detectable and stable in the blood of patients with cancer and cardiovascular disease. We tested whether circulating lncRNAs in plasma of critically ill patients with acute kidney injury (AKI) at inception of renal ...
Chen Chien-Kuang CK Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, - - 2014
Background: Although blebs and bullae are frequently found in the apexes of lungs of patients with primary spontaneous pneumothorax (PSP), its pathogens remain unclear. Objectives: To examine the role of proteases [matrix metalloproteinase (MMP)-2, MMP-7 and MMP-9] and antiproteases [tissue inhibitors of metalloproteinase (TIMP)-1, TIMP-2, TIMP-3 and TIMP-4] in the ...
Hubner Pia P Department of Emergency Medicine, General Hospital of Vienna, Medical University of Vienna, Vienna, - - 2014
Sudden cardiac arrest as a complication of neurologic disorders is rare, occasionally acute neurologic events present with cardiac arrest as initial manifestation. Our aim was to describe neurologic disorders as a cause of cardiac arrest in order to enable better recognition. We retrospectively analyzed prospectively collected resuscitation data of all ...
Doesch Christina C 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany. Electronic address: - - 2014
Dilated cardiomyopathy (DCM) shows a variable disease course and is associated with significant morbidity and mortality. So far, left ventricular function (LVF) is the major determinant for risk stratification. However, since it has shown to be a poor guide to individual outcome, we studied the prognostic value of cardiovascular magnetic ...
Mahiques-Santos L L Servicio de Dermatología, Hospital La Plana, Villa Real, Castellón, España. Electronic address: - - 2014
Psoriasis is a chronic inflammatory disease associated with an increased risk of ischemic coronary artery disease (CAD) in some populations. We aimed to determine the association between these 2 diseases in our geographic area. We performed a cross-sectional study of patient records between 2005 and 2012 in the database (Abucacis, ...
Díaz-Rubia L L Intensive Care Unit, Virgen de las Nieves Hospital, Granada, - - 2014
To analyze the efficacy of negative fluid balance in hypoxemic patients with an elevated extravascular lung water index (EVLWI). A retrospective observational study was made. Intensive Care Unit of Virgen de las Nieves Hospital (Spain). Forty-four patients participated in the study. We analyzed our database of hypoxemic patients covering a ...
Chen Zhenping Z Beijing Key Laboratory of Pediatric Hematology Oncology;National Key Discipline of Pediatrics, Ministry of Education;Key Laboratory of Major Diseases in Children, Ministry of Education;Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, 56 Nanlishi Road, Beijing 100045, China. Electronic address: - - 2014
To investigate the status of DNA methylation in the Foxp3 promoter in paediatric ITP patients and assess the role of DNA methylation of Treg cells in the pathogenesis of ITP. Quantitative DNA methylation levels of Foxp3 promoter in paediatric ITP patients were detected by MassARRAY EpiTYPER. Methylation levels of Foxp3 ...
Poddar Kanhaiya L KL Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, - - 2014
We investigated whether patients with patent foramen ovale (PFO) have an increased risk of stroke due to permanent pacemaker (PPM)/implantable cardioverter-defibrillator (ICD) implantation. Data are lacking on the risk of stroke in patients with PFO and implantable intracardiac devices, either a PPM or an ICD. We investigated whether patients with ...
Chen Edwin E Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Cambridge Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United - - 2014
Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as an early somatic event in most patients with myeloproliferative neoplasms (MPNs), and the ...
Saif Aasem A Cairo - - 2014
We evaluated the renal vascular indices in children and adolescents with sickle cell disease (SCD) using Doppler ultrasonography. We also assessed the renal hemodynamics alterations in patients with homozygous SCD and sickle beta-thalassemia (sickle β-thalassemia). We studied 75 patients (age range = 3-20 years; M = 9.95 ± 4.15) with ...
Myers Kasiani C KC Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA. Electronic address: - - 2014
Veno-occlusive disease (VOD) of the liver is a well-described and significant complication of hematopoietic stem cell transplantation (HSCT), with limited successful therapeutic options in severe cases. Prompt diagnosis and initiation of treatment is crucial to restrict the extent of disease. However, a subset of patients may not meet all current ...
Pasquali Livia L Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: - - 2014
In multiple sclerosis (MS) oxidative injury likely plays a major role in disease progression and in damaging tissue in the central nervous system (CNS), although with different mechanisms in the initial and the progressive disease stages. We compared the biomarker levels of plasmatic oxidative stress in patients with relapsing remitting ...
Cardo Lucía F LF Genética Molecular-Laboratorio de Medicina, Hospital Universitario Central de Asturias, 33006, Oviedo, - - 2014
The deregulation of several microRNAs (miRNAs) has been associated with neurodegenerative processes, including Parkinson's disease (PD). Our aim was to characterize the level of miRNAs in the substantia nigra (SN) of PD patients and healthy donors. This is an important issue to characterize new putative markers and therapeutic targets for ...
Kim Dae Suk DS Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of - - 2014
Cutaneous vasculitis can be limited to skin or a manifestation of primary systemic vasculitis. However, there are no definite markers to predict systemic involvements. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. We evaluated whether RDW can ...
Grozdanov Veselin V Department of Neurology, Ulm University, Albert Einstein Allee 11, 89081, Ulm, - - 2014
Despite extensive effort on studying inflammatory processes in the CNS of Parkinson's disease (PD) patients, implications of peripheral monocytes are still poorly understood. Here, we set out to obtain a comprehensive picture of circulating myeloid cells in PD patients. We applied a human primary monocyte culture system and flow cytometry-based ...
Tyrakowski Marcin M Department of Orthopedics, Pediatric Orthopedics and Traumatology, The Centre of Postgraduate Medical Education in Warsaw, Konarskiego 13, 05-400, Otwock, Poland, - - 2014
The aim of this study was to compare radiographic sagittal spinopelvic parameters between skeletally immature and skeletally mature patients with Scheuermann's disease (SD). Cross-sectional analysis of standing postero-anterior and lateral radiographs of the spine of patients with SD was performed. Sagittal vertical axis (SVA), thoracic kyphosis (TK), thoracolumbar kyphosis (TLK), ...
Chen Shasha S National Clinical Research Centre of Kidney Desease, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, - - 2014
The objectives of the study were to investigate the pathological features and renal prognosis of severe lupus patients with rapidly progressive glomerulonephritis. One hundred and one cases of biopsy-proven severe LN with rapidly progressive glomerulonephritis (RPGN) were analyzed in this retrospective study. Another 200 severe LN patients without RPGN were ...
Suda Kentaro K Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, - - 2014
The prevalence of acromegaly is estimated to be 8-24/100,000, but several recent studies suggest it is underestimated. In particular, acromegaly is considered more prevalent in patients with type 2 diabetes mellitus (T2DM) than in the normal population. This study aimed to evaluate the prevalence of acromegaly in hospitalized patients with ...
Bagheri-Hanson Azadeh - - 2014
Nasal potential difference (NPD) and intestinal current measurement (ICM) are functional CFTR tests that are used as adjunctive diagnostic tools for cystic fibrosis (CF). Smoking has a systemic negative impact on CFTR function. A diagnostic comparison between NPD and ICM and the impact of smoking on both CFTR tests has ...
Kondziella Daniel D Department of Neurology, Rigshospitalet, Copenhagen University Hospital, 2100, Copenhagen, Denmark, - - 2014
Continuous EEG (cEEG) may allow monitoring of patients with aneurysmal subarachnoid hemorrhage (SAH) for delayed cerebral ischemia (DCI) and seizures, including non-convulsive seizures (NCSz), and non-convulsive status epilepticus (NCSE). We aimed to evaluate: (a) the diagnostic accuracy of cEEG as a confirmatory test, (b) the prognostic value of EEG patterns ...
Ataseven A A Department of Dermatology, Konya Training and Research Hospital, Konya, Turkey - - - 2014
Psoriasis is a chronic relapsing inflammatory skin disease. Vaspin, vascular adhesion protein--1 (VAP--1), YKL--40, and high--sensitivity C--reactive protein (hs--CRP) are inflammatory biomarkers. However, with the exception of hs--CRP, the role of these markers in the pathogenesis of psoriasis is yet to be elucidated. This study investigated vaspin, VAP--1, YKL--40, and ...
Kang Yeonah Y Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, - - 2014
Evidence of intracranial venous reflux flow due to jugular venous reflux (JVR) on time of flight (TOF) MR angiography (MRA) is thought to be highly associated with transient global amnesia (TGA)-evidence that supports the venous congestion theory of TGA pathophysiology. However, recent studies indicate that intracranial JVR on TOF MRA ...
Yang Peng-Fan PF Department of Neurosurgery, Fuzhou General Hospital of Nanjing Command, PLA, North Road 156, West Second Ring, Fuzhou, 350025, China, - - 2014
We reported our experience in the surgical treatment of a relatively large cohort of patients with occipital lobe epilepsy (OLE). We also carried out a systematic review of the literature on OLE. Thirty-five consecutive patients who underwent occipital resection for epilepsy were included. Diagnoses were made following presurgical evaluations, including ...
Chee Elaine E Singapore National Eye Center , Singapore - - 2014
Abstract Purpose: To describe the association of lacrimal gland inflammation with alopecia areata. Methods: We reviewed the medical records of 4 patients diagnosed with lacrimal gland inflammation who had an antecedent or subsequent episode of alopecia. Data was collected on the presentation age, gender, medical history, disease onset, symptoms and ...
Desai Vibha C A VC University of Cincinnati Academic Health Center, Cincinnati, OH, - - 2014
For patients with atrial fibrillation (AF), early treatment is essential to prevent serious complications such as stroke. Several randomized clinical trials have shown that rate-control may be as effective as rhythm-control medications, whereas the latter have serious side effects. Little evidence exists, however, about which class of rate-control medication-β-blockers (BBs) ...
Thelin Johan J Department of Clinical Sciences, Lund University, Sweden Deparment of Internal Medicine, Skåne University Hospital, Sweden - - 2014
To examine whether undetectable high sensitivity troponin T (hsTnT) can be used to safely rule out non-ST-elevation acute coronary syndrome (NSTE-ACS) (using the limit of detection (LOD) as the cut-off) and to compare this strategy to serial hsTnT and the use of combined hsTnT and copeptin. In this prospective observational ...
Tsuboi Takashi T Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, - - 2014
To elucidate the phenotypes and pathophysiology of speech and voice disorders in Parkinson's disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS). We conducted a cross-sectional study on 76 PD patients treated with bilateral STN-DBS (PD-DBS) and 33 medically treated PD patients (PD-Med). Speech and voice functions, electrode positions, motor ...
Wild Beate B Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Germany. Electronic address: - - 2014
The aim of this study was to examine the features and changes of the cortisol awakening response (CAR) in patients with anorexia nervosa (AN) with severe and less severe symptoms over the course of inpatient treatment. Our study included n=20 AN patients who received treatment at the University Hospital, Heidelberg. ...
Wang Wanhua W Department of Neurosurgery and Neurology, The First People's Hospital of Kunshan, Jiangsu University, Suzhou, P. R. - - 2014
Many diseases include microRNAs (miRNAs) as reported biomarkers. The significance of circulating miRNAs for early diagnosis of acute stroke in humans is unknown. We aim to determine whether circulating miRNAs potentially serve as novel biomarkers for acute stroke. We prospectively recruited patients with acute stroke and those with nonstroke disease. ...
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