Search Results
Results 451 - 500 of 1840
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Sakata Kenneth K KK Mayo Clinic, Department of Internal Medicine, Scottsdale, Arizona, United States ; - - 2014
Rationale: The serum procalcitonin assay has emerged as a promising biomarker to distinguish between bacterial and viral respiratory tract infections but has not been used to differentiate coccidioidomycosis from bacterial infection. A correlation between procalcitonin serum levels and coccidioidomycosis has never been reported. Objective: To determine any association between serum ...
Yang Lingli L Department of Dermatology, Osaka University Graduate School of Medicine, Laboratory of Immune Signal, National Institute of Biomedical Innovation, Department of Dermatology, Kanazawa University, Kanazawa, Biomolecular Dynamics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto and National Institute of Biomedical Innovation, Osaka, Japan. Department of Dermatology, Osaka University Graduate School of Medicine, Laboratory of Immune Signal, National Institute of Biomedical Innovation, Department of Dermatology, Kanazawa University, Kanazawa, Biomolecular Dynamics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto and National Institute of Biomedical Innovation, Osaka, - - 2014
The aim of this study was to identify cold-associated autoantibodies in patients with RP secondary to CTDs. Indirect immunofluorescence staining was performed on non-permeabilized cold-stimulated normal human dermal microvascular endothelial cells (dHMVECs), using patients' sera. Cold-induced alterations in cell surface proteomes were analysed by isobaric tag for relative and absolute ...
Bokov Plamen P AP-HP, Hôpital européen Georges-Pompidou, Service de Physiologie-Clinique de la Dyspnée, 75015 Paris, - - 2014
Airway anatomy could be a risk factor for asthma in susceptible patients with airway hyperresponsiveness. This anatomy can be described by only two parameters, the tracheal cross-sectional area and the homothety ratio, which describes the reduction of calibre at each subsequent generation. Thus, we hypothesised that the tracheal area would ...
Zhang Fangfang F Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, PR - - 2014
It has long been debated whether a progressive process is involved in schizophrenia. The aim of the current study was to determine whether a progressive process was involved in patients with early schizophrenia, who were drug naive or had received short-term minimal antipsychotic treatment to avoid the distortion through medication ...
Figueroa David D Knee Surgery Unit, Orthopaedics and Traumatology Department, Clínica Alemana - Universidad del Desarrollo, Santiago, Chile. Electronic address: - - 2014
To describe the clinical outcomes of patients over 50years of age with following anterior cruciate ligament (ACL)reconstruction for acute rupture. A prospective series of patients over the age of 50years with a diagnosis of ACL rupture who underwent ACL reconstruction was examined. Lysholm and International Knee Documenting Committee (IKDC) subjective ...
Zoulim Fabien F Hepatology Department, Hospices Civils de Lyon, INSERM U1052, Lyon University, Lyon, France. Electronic address: - - 2014
Serum hepatitis B surface antigen (HBsAg) levels may predict treatment response in chronic hepatitis B (CHB). We examined the association between changes in HBsAg levels and response to treatment in the BE-LOW study. In this open-label, multicenter study, 379 nucleos(t)ide-naïve patients with hepatitis B e antigen (HBeAg)-positive or -negative CHB ...
Tursi Antonio A Gastroenterology Service, ASL BAT, Via Torino, 49, 76123 Andria (BT), Italy. Electronic address: - - 2014
There are few data on how histological signs of inflammation develop under treatment with infliximab (IFX). We investigated the patterns of histological features of inflammation in patients with UC in sustained clinical and endoscopic remission under IFX. We performed a retrospective study on 47 patients with UC in clinical and ...
Malek Marta M Clinic of Dermatology, Venereology and Allergology, Medical University in Gdańsk, Polish Lymphoma Research Group, 80-210 Gdańsk, Poland. - - 2014
Mycosis fungoides (MF) and Sézary syndrome belong to the group of primary cutaneous T-cell lymphomas (CTCL). Regardless of the stage of the disease, patients with MF and Sézary syndrome can suffer from chronic pruritus. The aim of the study was to investigate the correlation between the interleukin 31 (IL-31) serum ...
Held Matthias - - 2014
Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication following an acute pulmonary embolism (PE). It is frequently diagnosed at advanced stages which is concerning as delayed treatment has important implications for favourable clinical outcome. Performing a follow-up examination of patients diagnosed with acute PE regardless of persisting symptoms and ...
Park Kwiyoung K Multiple Sclerosis Center, Utano National Hospital, Kyoto, - - 2014
To evaluate and compare the incidence and clinical features of Uhthoff's phenomenon in Japanese patients with neuromyelitis optica (NMO) and those with multiple sclerosis (MS), we asked 135 consecutive patients with MS and an NMO-related disorder (NMOrd) whether they experienced worse neurological symptoms after an increase in body temperature. Responses ...
Zhao Mangsuo M Department of Neurology, Yuquan Hospital, Medical Center, Tsinghua University, No. 5 Shijingshan Road, Beijing 100049, PR - - 2014
The cerebrospinal fluid (CSF) shows inflammatory changes in patients with idiopathic hypertrophic pachymeningitis (IHP), which is a rare disorder. However, systemic CSF research including immunoglobulins in patients with IHP are substantially lacking. In the study, clinical, laboratory, neuroradiologic and therapeutic data from 9 patients with IHP were retrospectively studied, and ...
Boonyawat Kochawan K Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, - - 2014
Heparin induced-thrombocytopenia (HIT) has been well recognized in Western countries. However, there are no data in the Thai population. We therefore investigated the prevalence of anti-platelet factor 4 (PF4)/heparin antibodies, HIT, and its thrombotic complications in Thai patients undergoing cardiac surgery using unfractionated heparin. Seventy-three consecutive patients were prospectively enrolled ...
Sprenker Collin C Florida Gulf to Bay Anesthesiology Associates LLC, Tampa, FL - - 2014
Common management of angionegative subarachnoid hemorrhage includes mandatory intensive care unit stay for up to 14 days with strict bedrest, constant neurologic serial examination, invasive arterial and central line monitoring, and aneurysm rupture precautions. We evaluated the frequency of neurologic and nonneurologic complications in this patient population. This was a ...
Alfieri Veronica - - 2014
BackgroundWe investigated whether a relationship between small airways dysfunction and bronchial hyperresponsiveness (BHR), expressed both in terms of ease of airway narrowing and of excessive bronchoconstriction, could be demonstrated in asthma.Methods63 (36 F; mean age 42 yr¿±¿14) stable, mild-to-moderate asthmatic patients (FEV1 92% pred ±14; FEV1/FVC 75%¿±¿8) underwent the methacholine challenge test ...
Komatsu Yoshihiro Y Institute for the Treatment of Esophageal and Thoracic Disease, Allegheny Health Network, Pittsburgh, PA, - - 2014
The management of laryngopharyngeal reflux (LPR) has been challenging. Hypopharyngeal multichannel intraluminal impedance (HMII) has shown to increase the sensitivity in diagnosing LPR. The objective of this study is to investigate the potential use of pepsin and Sep70 as diagnostic tools for detection of LPR in combination with HMII. Tissue ...
Di Lello F A FA Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Avenida de Bellavista s/n., 41014, Seville, - - 2014
The aim of this study was to analyze the impact of core variations on sustained virological response (SVR) to pegylated interferon plus ribavirin (PEG-IFN/RBV) and its association with predictive factors of response in Caucasian patients infected with genotype 1 hepatitis C virus (HCV-1). Full-length core sequences were analyzed in 100 ...
Zugck Christian C Clinic/Group Practice for Internal Medicine, Steiner Thor, Straubing, Germany, - - 2014
In the prospective, open-label multicenter INTENSIFY study, the effectiveness and tolerability of ivabradine as well as its impact on quality of life (QOL) in chronic systolic heart failure (CHF) patients were evaluated over a 4-month period. In CHF patients with an indication for treatment with ivabradine, resting heart rate (HR), ...
Rogalski Emily E From the Cognitive Neurology and Alzheimer's Disease Center (E.R., A.M., C.W., S.W., M.-M.M.), and Departments of Psychiatry and Behavioral Sciences (D.C., S.W.), Preventative Medicine (A.R.), and Neurology (M.-M.M.), Northwestern University Feinberg School of Medicine, Chicago, IL. - - 2014
The aim of this study was to provide quantitative measures of changes in cortical atrophy over a 2-year period associated with 3 subtypes of primary progressive aphasia (PPA) using whole-brain vertex-wise and region-of-interest (ROI) neuroimaging methods. The purpose was to quantitate disease progression, establish an empirical basis for clinical expectations, ...
Zaytseva Yuliya Y Moscow Research Institute of Psychiatry, Moscow, Russia; Human Science Centre, Institute of Medical Psychology, Ludwig Maximilian University, Munich, Germany; Prague Psychiatric Centre, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. Electronic address: - - 2014
Patients with schizophrenia frequently exhibit motor deficits. However, to date, there are no studies comparing motor performance in first episode patients with schizophrenia and schizophrenia spectrum disorders (SSD; e.g. schizoaffective and brief psychosis). Participants comprised 57 first episode patients with schizophrenia, 32 first episode patients with SSD, and 51 healthy ...
Altit Gabriel G Department of Pediatrics, Université de Montréal, Faculté de Médecine, Montréal, Québec, - - 2014
Ascending aortic dilatation (AoD) in patients with structurally normal hearts and congenital heart block (CHB) has been previously described. The cause and management of AoD are yet to be determined. The aim of this study was to test the hypothesis that AoD in children with CHB regresses after the implantation ...
Preiss Joshua E JE Department of Surgery, Emory University, Atlanta, - - 2014
Contralateral occlusion (CLO) occurs in approximately 8% of patients undergoing intervention for carotid artery stenosis. Patients with CLO have increased stroke risk compared with patients without CLO, but standard carotid duplex ultrasonography (CDUS) criteria are not a reliable manner to screen or follow patients with CLO. Because appropriate duplex criteria ...
Husain N N Department of Medicine, Baylor College of Medicine, Houston, TX, USA; Section of Gastroenterology and Hepatology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, - - 2014
In practice, nonalcoholic fatty liver disease (NAFLD) is diagnosed based on elevated liver enzymes and confirmatory liver biopsy or abdominal imaging. Neither method is feasible in identifying individuals with NAFLD in a large-scale healthcare system. To develop and validate an algorithm to identify patients with NAFLD using automated data. Using ...
Janati A Bruce AB Center for Neurology, Fairfax, VA, USA, - - 2014
There is a plethora of data in the EEG literature on the characteristics of the most prominent component of interictal epileptiform discharges (IED), namely the negative (fast) phase. Surprisingly, however, little attention has been drawn to the after-coming slow wave (ASW), and its pathological as well as clinical significance. In ...
Müller T J TJ Department of Neurology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120, Halle (Saale), - - 2014
Objective. To characterize the phenotype of patients with distal myopathy with vocal cord and pharyngeal weakness (VCPDM) due to the p.S85C mutation in the Matrin 3 gene (MATR3, MIM 164015). Recently it has been suggested that patients with this mutation may suffer from familial amyotrophic lateral sclerosis. Patients and methods. ...
Karabul Nesrin N Villa Metabolica, Centre for Pediatric and Adolescent Medicine, Langenbeckstr. 2, 55131, Mainz, - - 2014
Objective: To determine the frequency and impact of gastrointestinal symptoms, and bowel and urinary incontinence, as this is currently unknown in adults with Pompe disease. Methods: Adult German Pompe patients and age- and gender-matched controls were asked about symptoms in the upper and lower intestinal tract as well as urinary ...
Fernandes Julien J Unité de Pathogenèse de Helicobacter, CNRS ERL3526, Institut - - 2014
Background: Gastric cancer (GC) represents a major health burden worldwide often diagnosed at an advanced-stage. Biomarkers for screening and prevention of GC are missing. Changes in peripheral blood mitochondrial DNA (mtDNA) have emerged as potential preventive/diagnosis biomarker for cancer risk. We aimed to determine whether peripheral leucocytes mtDNA levels are ...
Pareés Isabel I 1 Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, - - 2014
Functional movement disorders require attention to manifest yet patients report the abnormal movement to be out of their control. In this study we explore the phenomenon of sensory attenuation, a measure of the sense of agency for movement, in this group of patients by using a force matching task. Fourteen ...
Korkmaz Levent L aDepartment of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital bDepartment of Radiology, Akcaabat State Hospital, Trabzon, - - 2014
Detection of increased arterial stiffness could prevent patients from being mistakenly classified as being at a low or a moderate risk, when they actually are at a high risk. The main aim of present study was to investigate the relation between fragmented QRS (fQRS) on ECG and the cardio-ankle vascular ...
Matsushita Hiroshi H Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, - - 2014
Inappropriate innate immune responses have been suggested to contribute to the pathogenesis of primary sclerosing cholangitis (PSC). We evaluated the associations of expressions of toll-like receptor (TLR) 4, TLR9 and NOD-like receptor family pyrin domain containing 3 (NLRP3) in the biliary epithelial cells (BECs) with clinical features of PSC patients. ...
Schnakers Caroline C University Hospital of Liège, Liège, Belgium University of Liège, Liège, Belgium - - 2014
Background. Despite recent evidence suggesting that some severely brain-injured patients retain some capacity for top-down processing (covert cognition), the degree of sparing is unknown. Objective. Top-down attentional processing was assessed in patients in minimally conscious (MCS) and vegetative states (VS) using an active event-related potential (ERP) paradigm. Methods. A total ...
Mendoza-Pinto C C Systemic Autoimmune Diseases Research Unit, IMSS, Puebla, Mexico Department of Rheumatology and Immunology, Benemérita Universidad Autónoma de Puebla, - - 2014
Low bone mineral density (BMD) and vertebral fractures (VF) have been associated with atherosclerosis in the general population. We sought to investigate the relationship between BMD and VF and carotid atherosclerosis in women with systemic lupus erythematosus (SLE). We studied 122 women with SLE. All patients had BMD, carotid intima-media ...
Liu Yong Y Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China These authors contributed equally to this - - 2014
We determined a relatively safe contrast media volume-to-creatinine clearance (V/CrCl) cutoff value to avoid contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients (n = 111) with reduced ejection fraction (<40%). Improved prediction of CIN in these patients would be useful. Multivariate regression models were used to evaluate whether ...
Akyüz Aydın A Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdağ, Turkey - - 2014
This study investigated whether there is a relationship between atrial fibrillation (AF), mean platelet volume (MPV), and apnea hypopnea index (AHI) in patients who have obstructive sleep apnea syndrome (OSAS). We enrolled patients who had OSAS with either AF or normal sinus rhythm (NSR). We divided 90 patients (aged 50-80 ...
Ceresini Graziano G Department of Clinical and Experimental Medicine, Endocrinology of Aging Unit, University of Parma, Parma, Italy. Electronic address: - - 2014
Idiopathic retroperitoneal fibrosis (IRF) is a rare disease often associated with autoimmune disorders. Whether IRF is associated with Hashimoto's thyroiditis (HT) is poorly understood and only addressed by case-reports. We evaluated the prevalence of HT in a large IRF cohort and in matched controls. We studied 73 consecutive patients with ...
Talar-Wojnarowska Renata R Department of Digestive Tract Diseases, Medical University of Lodz, Poland. Electronic address: - - 2014
Autoimmune pancreatitis (AIP) can mimic pancreatic cancer in its clinical presentation, imaging features and laboratory parameters. The aim of our study was to compare IgG, IgG4 and anti-CAIIAb serum levels in patients with AIP, pancreatic adenocarcinoma (PA) and chronic pancreatitis (CP) and to assess their clinical significance and utility in ...
Kim Ik Yong IY Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, - - 2014
We report a case of synchronous multiple colon adenocarcinomas in a patient with neurofibromatosis type 1 (NF1). NF1 is an autosomal dominant inherited disorder and patients with NF1 have high risk for both benign and malignant tumors. However, adenocarcinomas involving the colon have rarely been reported in patients with NF1. ...
Yoon Jiho J Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, - - 2014
Endometriosis is defined as functioning endometrial tissue outside of the uterus. Endometriosis of the appendix is uncommon. Its clinical presentation varies from asymptomatic to acute abdominal pain. The aims of this study were to describe our experience of managing patients with appendiceal endometriosis and to review the clinical characteristics of ...
Ahn J HyunBaek JH Department of Oral and Maxillofacial Surgery, Northampton General Hospital, Northampton, United - - 2014
Background The anterolateral thigh flap has gained popularity over the last few decades for the reconstruction of various surgical defects. The anatomy of the main perforating vessel of the anterolateral flap, the descending branch of the lateral circumflex femoral artery (dbLCFA), has been well described in the literature, however only one ...
Blight Andrew R AR Acorda Therapeutics, Ardsley, New - - 2014
Walking impairment is a clinical hallmark of multiple sclerosis (MS). Dalfampridine-ER, an extended-release formulation of dalfampridine (also known by its chemical name, 4-aminopyridine, and its international nonproprietary name, fampridine), was developed to maintain drug plasma levels within a narrow therapeutic window, and assessed for its ability to improve walking in ...
Dahlqvist J R JR Neuromuscular Research Unit, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, - - 2014
Patients with myotonic dystrophy type 1 (DM1) have an increased incidence of endocrine dysfunction. In this study, the temporal evolution of endocrine dysfunction in patients with DM1 was investigated. Endocrine function was assessed in 68 patients with DM1, in whom endocrine function had been followed, on average, for 8 years. The ...
Kosturakis Alyssa K AK Alyssa K. Kosturakis, Zijing He, Yan Li, Nina Shah, Sheeba K. Thomas, Haijun Zhang, Elisabeth G. Vichaya, Xin Shelley Wang, Charles S. Cleeland, and Patrick M. Dougherty, University of Texas MD Anderson Cancer Center, Houston, TX; Jessica A. Boyette-Davis, York College, York, PA; Gwen Wendelschafer-Crabb and William R. Kennedy, University of Minnesota School of Medicine; and Donald A. Simone, University of Minnesota School of Dentistry, Minneapolis, - - 2014
The goal in this study was to determine the incidence of subclinical neuropathy in treatment-naive patients with multiple myeloma (MM) with no history of peripheral neuropathy using quantitative sensory tests (QSTs) and its correlation with innervation density of the extremities using noninvasive laser reflectance confocal microscopy. QST results were collected ...
Tani N N Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, - - 2014
Systematic study of pemphigoid gestationis (PG) has not been performed due to rarity of PG. Clinical and immunological analyses for 25 new PG patients. In addition to clinical and histopathological assessments, we performed various immunofluorescence, immunoblotting and enzyme-linked immunosorbent assays (ELISAs). PG developed preferentially during second or third trimester of ...
Kaido T T Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, - - 2014
Severe sepsis is a life-threatening complication after liver transplantation (LT) that can be difficult to diagnose and appropriately treat after LT because of patients being treated with immunosuppressants. The present study examines perioperative changes in serum procalcitonin (PCT), a specific marker of systemic bacterial infection, and determines the value of ...
Hung Szu-Chun SC Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Buddhist Tzu Chi University, - - 2014
The introduction of erythropoiesis-stimulating agents (ESAs) markedly improved the lives of many anemic patients with chronic kidney disease (CKD). In Taiwan, the strategy of management of anemia in patients with CKD was different from many other parts of the world. In 1996, the National Health Insurance Administration of Taiwan applied ...
Takeuchi Naoyuki N 1Department of Physical Medicine and Rehabilitation, Tohoku University Graduates School of Medicine, Sendai, Japan 2Rehabilitation Support Center, Miyagi Prefectural Government, Natori, - - 2014
Sensorimotor rhythm (SMR) patterns in patients with lower limb amputations might be altered due to reorganization of the sensorimotor cortices. We evaluated the SMR of motor imagery (MI) in healthy subjects and patients with lower limb amputations. In addition, we investigated whether transcranial direct current stimulation (tDCS) could modulate SMR ...
El-Chammas Khalil I KI *Mercy Medical Center, Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition Des Moines, IA †Makassed Hospital, Department of Pediatrics, Division of Pediatric Pulmonology, Jerusalem, Israel ‡Boston University, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Boston, MA §Medical College of Wisconsin, Department of Pediatrics, Division of Pediatric Pulmonology, Milwaukee, WI ||Medical College of Wisconsin, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Milwaukee, - - 2014
Screening for cystic fibrosis (CF) is suggested in patients with rectal prolapse. Little is known about this association in the era of newborn screening (NBS) for CF. Our retrospective review showed that 3.6% of patients with rectal prolapse had CF, and 3.5% of CF patients had rectal prolapse. No demographic ...
Andreu-Ballester Juan C JC Research Department, Arnau de Vilanova Hospital, Valencia, Spain. Electronic address: - - 2014
We recently demonstrated an overall decrease of all αβ and specially γδ T cell subsets in patients with sepsis compared with healthy subjects. IL-7 is a crucial factor for development of γδ T cells and survival in sepsis but its association with sepsis severity, evolution of organ failure and death ...
Vreede C L CL Department of Pulmonology, Haga Teaching Hospital, Leyweg 275, 2545 CH The Hague, The - - 2014
In patients with Cystic Fibrosis and a type III mutation, ivacaftor (Kalydeco®, Vertex) can increase the opening time of the CFTR channel and improve chloride transport. Research showed significant improvement of lung function and increase in weight following ivacaftor use. However, ivacaftor showed to have adverse events on the sinonasal ...
Yamashita Takeshi T The Cardiovascular Institute, Tokyo, Japan. Electronic address: - - 2014
To maximize protection against stroke with minimal bleeding, warfarin therapy in nonvalvular atrial fibrillation (NVAF) requires tight control within a narrow therapeutic range, which might depend on racial variations. The J-RHYTHM Registry followed 6404 NVAF patients treated with warfarin for 2 years. Using international normalized ratios (INRs) at or closest ...
Huang Qing-Chun QC Department of Rheumatology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510006, - - 2014
Patients with rheumatoid arthritis (RA) appear to be at a higher risk of lung cancer (LC). Although the connection between RA and LC has been an active area of research for many years, the molecular pathogenesis of the disease process remains unclear. The cyclooxygenase (COX)-2/thromboxane A2 (TxA2) pathway has been shown ...
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