Search Results
Results 451 - 500 of 2279
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Debono Miguel M Academic Unit of Endocrinology, Department of Human Metabolism, University of Sheffield, Sheffield, UK (MD, RJR, JN-P); Medical Statistics and Clinical Trials Research Unit, The School of Health and Related Research, University of Sheffield, Sheffield, UK (MBr); The Departments of Endocrinology (MD, RJR, JN-P), Radiology (MBu) and Endocrine Surgery (BH), Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, - - 2014
Context: Incidental benign adrenocortical adenomas, 'adrenal incidentalomas', are found in 4.5% of abdominal CT scans, with the incidence increasing to 10% in patients over 70 years. These incidentalomas frequently show evidence of excess cortisol secretion but without overt Cushing's syndrome. The mortality rate is increased in Cushing's syndrome. Objective: To ...
Tanida Satoshi S Nagoya City University Graduate School of Medical Sciences, Aichi, - - 2014
& Aims: Behçet's disease is a chronic, relapsing inflammatory disease that can involve the mouth, skin, eyes, genitals, and intestines. Active intestinal Behçet's disease can be complicated by gastrointestinal (GI) bleeding and perforation. We performed a multicenter, open-label, uncontrolled study to evaluate the efficacy and safety of adalimumab, a fully ...
Chevalier-Bidaud Brigitte - - 2014
ATS/ERS Task Force has highlighted that special attention must be paid when FEV1 and FVC are concomitantly decreased (<5th percentile) and the FEV1/FVC ratio is normal (>5th percentile) because a possible cause of this non specific pattern (NSP) is collapse of small airways with normal TLC measured by body plethysmography ...
Sibila Oriol O Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Department of Medicine, Barcelona Respiratory Network (BRN), Barcelona, Spain. Electronic address: - - 2014
Airway bacterial colonization by potentially pathogenic microorganisms occurs in a proportion of patients with Chronic Obstructive Pulmonary Disease (COPD). It increases airway inflammation and influences outcomes negatively. Yet, its diagnosis in clinical practice is not straightforward. The electronic nose is a new non-invasive technology capable of distinguishing volatile organic compound ...
Song Xueqin X The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China. Electronic address: - - 2014
This study was to examine cortical thickness in drug naïve, first episode schizophrenia patients, and to explore its relationship with serum levels of brain-derived neurotrophic factor (BDNF). Forty-five drug naive schizophrenia patients and 28 healthy controls were enrolled in the study. Freesurfer was used to parcellate cortical regions, and vertex-wise ...
Barbieri L L Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, - - 2014
Contrast Induced Nephropathy (CIN) is a common complication of procedures that require the use of contrast media, and seems to be mediated by oxidative stress and reactive oxygen species generation. Hyperuricemia is characterized by inhibited nitric oxide system and enhanced synthesis of reactive oxygen species. However, few studies have so ...
Park Young Min YM Department of Otorhinolaryngology, Pundang Jesaeng Hospital, Deajin Medical Center, Seongnam, Gyeonggi, - - 2014
We investigated extrathyroidal extension (ETE) through frozen biopsy for intraoperative decision making in patients with papillary thyroid cancer (PTC). During the period of the study an operation was performed in 268 patients with PTC and ETE was evaluated using intraoperative frozen biopsies of thyroid tissue. Extrathyroidal extension was confirmed in ...
Paudel Klara K Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, - - 2014
Bioimpedance spectroscopy (BIS), ultrasound of lungs (lung ultrasound comets: LUC) and serum biomarkers (N-Terminal pro-brain natriuretic peptide, NT-proBNP) have been used to assist clinicians to determine hydration status in dialysis patients. But how do they compare? We performed simultaneous measurements of BIS, LUC and NT-proBNP in 27 peritoneal dialysis patients ...
Matsuda Shunichi S Department of Neurology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, - - 2014
The aim of paper was to investigate abnormalities in visual scanning using an eye-tracking device with patients with spinocerebellar ataxia type 6 (SCA6) and SCA31, pure cerebellar types of spinocerebellar degeneration. Nineteen SCA patients (12 patients with SCA6 and 7 patients with SCA31) and 19 normal subjects in total participated ...
Terashi Hiroo H aDepartments of - - 2014
Abstract Background: There is a need to define the basic characteristics of various kinematic parameters recorded during walking in patients with vascular parkinsonism (VP). The present study was designed to determine the kinematic features of walking in VP patients. For this purpose, gait acceleration and cycle were recorded continuously over ...
Celikoglu Mevlut M a Associate Professor, Department of Orthodontics, Faculty of Dentistry, Akdeniz University, Antalya, - - 2014
Objective: To evaluate the mandibular dental, alveolar, and skeletal transversal widths in patients affected by unilateral (UCLP) and bilateral (BCLP) cleft lip and palate and to compare the findings with a well-matched normal occlusion sample using cone beam computed tomography images. Materials and Methods: The study sample consisted of 75 ...
Siler Dominic A DA Department of Anesthesiology & Perioperative Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, - - 2014
Patients recovering from aneurysmal subarachnoid hemorrhage (SAH) are at risk for developing delayed cerebral ischemia (DCI). Experimental and human studies implicate the vasoconstrictor P450 eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE) in the pathogenesis of DCI. To date, no studies have evaluated the role of vasodilator epoxyeicosatrienoic acids (EETs) in DCI. Using mass ...
Hirashio Shuma S Department of Nephrology, Hiroshima University Hospital, Hiroshima, - - 2014
Telomeric G-tails play a pivotal role in maintaining the intramolecular loop structure of telomeres. Previous in vitro studies have suggested that the erosion of telomeric G-tails triggers cellular senescence, leading to organ dysfunction and atherosclerosis. The authors recently established a method to measure telomeric G-tail length using a hybridization protection ...
Olesen Jonas Bjerring JB Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark Department of Cardiology, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650 Hvidovre, Denmark - - 2014
Non-vitamin K antagonist oral anticoagulation (NOAC) agents have been approved for stroke prophylaxis in atrial fibrillation (AF). We investigated 'real-world' information on how these drugs are being adopted. Using Danish nationwide administrative registers, we identified all oral anticoagulation-naïve AF patients initiating oral anticoagulation from 22 August 2011 through 31 October ...
Miyake T T Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, - - 2014
Epstein-Barr virus (EBV)-associated T/NK lymphoproliferative disorders are a group of diseases that include classical and systemic hydroa vacciniforme (HV), and hypersensitivity to mosquito bites (HMB). Patients with systemic HV (sHV) and HMB often have a poor prognosis, although little is known about the prognostic factors. In order to elucidate the ...
Niyaz Leyla L Assistant Professor, Department of Ophthalmology, Ondokuz Mayis University Hospital, Samsun, Turkey - - 2014
A patient that developed paresis of the sixth cranial nerve and bilateral papilloedema after the bee sting to the periocular area is presented. Magnetic resonance venography showed a unilateral transverse and sigmoid sinus thrombosis. The patient was successfully treated with anticoagulation and intracranial pressure lowering treatment.
Meijer Julia H JH Academic Medical Center, Academic Psychiatric Centre, Department of Early Psychosis, University of Amsterdam, - - 2014
Olfactory identification deficits (OIDs) are seen in schizophrenia patients and individuals at increased risk for psychosis but its pathophysiology remains unclear. Although dopaminergic imbalance is known to lie at the core of schizophrenia symptomatology, its role in the development of OIDs has not been elucidated yet. This study investigated the ...
Keijzers Marlies M Department of Cardiothoracic Surgery, Maastricht University Medical Centre, Maastricht and GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands Department of Pulmonology, Maastricht University Medical Centre, Maastricht and GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, - - 2014
Thymectomy is frequently used in the treatment of myasthenia gravis (MG). But indication, timing or surgical approach remain controversial. This study reports our experiences with robotic thymectomy and surgical and neurological outcomes in a large cohort of patients with MG. We retrospectively analysed the outcome of 125 patients with MG ...
Alhajeri Hebah H Department of Medicine, McGill University, 845 Sherbrooke St W, Montreal, H3A 0G4, Quebec, Canada; Division of Rheumatology, Jewish General Hospital, 3755 Côte Ste-Catherine, Montréal, H3T 1E3, Quebec, - - 2014
Objective: The goal of this study was to determine the sensitivity of the new 2013 classification criteria for systemic sclerosis (SSc) in an independent cohort of SSc subjects and to assess the contribution of individual items of the criteria to the overall sensitivity. Method: SSc subjects from the Canadian Scleroderma ...
Aiyer Amiethab A AA Institute for Foot and Ankle Reconstruction, Mercy Medical Center, Baltimore, MD, USA - - 2014
Metatarsus adductus (MA) is a congenital condition in which there is adduction of the metatarsals in conjunction with supination of the hindfoot through the subtalar joint. It is generally believed that MA precedes the development of hallux valgus. Historically, studies have demonstrated that patients with a history of MA were ...
Yamamura Hitoshi - - 2014
We experienced four Japanese patients with spontaneous retroperitoneal bleeding, a rare disease. We categorized the clinical characteristics of spontaneous retroperitoneal bleeding in these patients treated in our hospital and discuss the risk factors of spontaneous retroperitoneal bleeding. Three of the 4 patients did not have a bleeding tendency as indicated ...
Poletti Michele M Department of Mental Health and Pathological Addiction, AUSL of Reggio Emilia, Reggio Emilia, - - 2014
Both impulse-control disorders and delusional jealousy (DJ) may be considered non-motor side-effects of dopamine agonist therapy in Parkinson's disease (PD). We aimed to investigate the possible concomitant development of these features in PD and their clinical correlates. We performed a cross-sectional investigation in 1063 consecutive PD patients with the Questionnaire ...
van Lümig P P M PP Department of Dermatology, Radboud university medical center, Nijmegen, The - - 2014
Concerns exist about a risk of non-melanoma skin cancer (NMSC) in psoriasis patients and rheumatoid arthritis (RA) patients treated with TNF-inhibitors. However, current data also show that in some psoriasis patients, NMSC is diagnosed relatively short after the start of TNF-inhibitors, which suggests that these NMSC can be explained by ...
Degirmenci Eylem E Department of Neurology, School of Medicine, Pamukkale University, Denizli, Turkey, - - 2014
Hemifacial spasm (HFS) is defined as an involuntary, irregular clonic, or tonic movement of muscles innervated by the ipsilateral seventh cranial nerve. It is reported that the coexistence of non-motor- and motor-related symptoms can be seen in patients with HFS. Postural disturbances were investigated in some movement disorders; however, postural ...
Athlin Simon S Department of Infectious Diseases, Örebro University Hospital, Sweden - - 2014
We studied the immunoglobulin (Ig) response to causative serotype-specific capsular polysaccharides in adult pneumococcal pneumonia patients. Serotypes were grouped according to degree of encapsulation and invasive potential. Seventy patients with pneumococcal pneumonia, 20 of whom were bacteremic, were prospectively studied. All pneumococcal isolates were serotyped and Ig titers to the ...
Arevalo-Manso Juan Jose JJ Department of Neurology and Stroke Centre, La Paz University Hospital; IdiPAZ, Hospital La Paz Institute for Health Research; Autonomous University of Madrid, Spain jjarevaloes@hotmail.com - - 2014
It is unknown whether monitors that include atrial fibrillation recognition software (AF-RS) increase the rate of early atrial fibrillation (AF) detection in acute stroke. We aimed to evaluate the AF detection rate of an AF-RS monitor and compare it with standard monitoring. This was a retrospective, single-centre observational study conducted ...
Del Valle Elisa E Department of Nephrology, Instituto de Investigaciones Metabólicas, Buenos Aires, - - 2014
Controversy exists on which vitamin D (D2 or D3) and which dosage scheme is the best to obtain and maintain adequate 25 OH D levels in dialysis patients safely. We tried to determine whether high-dose vitamin D2 supplementation could obtain optimal vitamin D status without inducing hypercalcemia. We studied 82 ...
Matika Ryan W RW Departments of Anesthesiology, * and Medicine, † the University of Arizona College of - - 2014
Chronic hemodialysis is associated with significant thrombophilia. Of interest, hemodialysis patients have increased carboxyhemoglobin and exhaled carbon monoxide (CO), signs of upregulated heme oxygenase (Hmox) activity. Given that CO enhances plasmatic coagulation, we determined if patients requiring chronic hemodialysis had an increase in endogenous CO, plasmatic hypercoagulability and decreased fibrinolytic ...
Wolff Anette S B AS Department of Clinical Science, University of Bergen, 5021 Bergen, Norway; - - 2014
Patients with the autoimmune polyendocrine syndrome type I (APS-I), caused by mutations in the autoimmune regulator (AIRE) gene, and myasthenia gravis (MG) with thymoma, show intriguing but unexplained parallels. They include uncommon manifestations like autoimmune adrenal insufficiency (AI), hypoparathyroidism, and chronic mucocutaneous candidiasis plus autoantibodies neutralizing IL-17, IL-22, and type ...
Malerba Mario M Department of Internal Medicine, University of Brescia, Italy. Electronic address: - - 2014
Chronic obstructive pulmonary disease (COPD) is characterized by poorly reversible airflow limitation, with an abnormal pulmonary and systemic inflammatory response to tobacco smoking. Systemic inflammation promotes atherosclerosis, to treat the complications of which beta-blockers are paramount. In the COPD setting, however, the use of beta-blockers has been limited by fears ...
Lee Min-Yi MY Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan Division of Cardiology, Department of Internal Medicine, Kaohsiung Municipal Min-Sheng Hospital, - - 2014
We aimed to determine the association between plasma aldosterone and renin levels as well as their ratios with carotid plaques in patients with coronary artery disease (CAD). Carotid intima-media thickness (IMT) and plaque score were evaluated in 111 patients with stable CAD. Plasma renin and aldosterone levels were measured in ...
Cresti Alberto A Cardiological Department, Misericordia Hospital, Grosseto, Italy. Electronic address: - - 2014
Atrial fibrillation (AF) and atrial flutter (AFL) are strong atrial thrombosis (THR) risk factors. In recent-onset tachyarrhythmias, the incidence of left atrial appendage (LAA) THR, detected by transesophageal echocardiography (TEE), has been widely studied, ranging from 6% to 18% (AF) and 4% to 11% (AFL). On the contrary, few studies ...
Halpenny Darragh F DF Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, United - - 2014
5% of lung adenocarcinomas harbor rearrangements of the anaplastic lymphoma kinase (ALK) gene. This study compared computed tomography (CT) imaging features in patients with ALK rearrangements and those with EGFR mutations. 30 patients with ALK rearrangements were studied. 97 patients with epidermal growth factor receptor (EGFR) mutations were used as ...
Chen G G 1] Department of Urology, China Rehabilitation Research Center, Beijing, China [2] Department of Urology, Capital Medical University, Beijing, - - 2014
Study design:Retrospective case series.Objectives:The primary aim was to assess the clinical effects of sacral neuromodulation (SNM) for neurogenic bladder and/or bowel dysfunction with multiple symptoms secondary to spinal cord disease or injury.Setting:Beijing, China.Methods:Between 2011 and 2013, 23 patients with multiple bladder and/or bowel problems secondary to spinal cord disease or ...
Unal Hilmi Umut HU Department of Nephrology - - 2014
Abstract Objective: To determine the relationships between inflammatory mediators, mitral annular calcification (MAC), and osteocalcin in patients with chronic kidney disease (CKD). Materials and methods: Echocardiographic data for 60 patients diagnosed as CKD were retrospectively evaluated. The patients were divided into 2 groups; patients with MAC (MAC+ group) and patients ...
Saedon M M University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK; Warwick Medical School, University of Warwick, Coventry, - - 2014
Transient cerebral microemboli are independent biomarkers of early risk of ischaemic stroke in acute carotid syndromes. Transcranial Doppler imaging (TCD) through the temporal bone is the standard method for detection of cerebral microemboli, but an acoustic temporal bone window for TCD is not available in around one in seven patients. ...
Joo Young-Hoon YH Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, - - 2014
Background: To evaluate the long-term swallowing function in patients with vertical hemipharyngolaryngectomy (VHPL) for hypopharyngeal cancer. Methods: A retrospective review of 30 patients followed for more than 2 years with VHPL between 1998 and 2011 was performed. Results: Five patients (16.7%) experienced gastrostomy tube placement, 4 patients (13%) pharyngoesophageal stricture, ...
Wigand Marlene M Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , - - 2014
Objectives. The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are likely relevant to the pathogenesis of auditory verbal hallucinations (AVHs). The aim of this study was to examine this ...
Del Sorbo Lorenzo L 1Dipartimento di Anestesiologia e Rianimazione, Azienda Ospedaliera Città della Salute e della Scienza e di Torino, Università di Torino, Torino, Italy. 2Respiratory and Critical Care Unit, Department of Specialist, Diagnostic and Experimental Medicine (DIMES), Sant'Orsola Malpighi Hospital, Alma Mater University, Bologna, Italy. 3Thoracic Surgery Unit, Sant'Orsola Malpighi Hospital, Alma Mater University, Bologna, Italy. 4Unit of Clinical Epidemiology, Azienda Ospedaliera Città della Salute e della Scienza e di Torino and CPO Piemonte, Torino, Italy. 5Dipartimento di Emergenza ed Accettazione, Unità di Medicina d'Urgenza, Azienda Ospedaliera Città della Salute e della Scienza e di Torino, Università di Torino, Torino, - - 2014
To assess efficacy and safety of noninvasive ventilation-plus-extracorporeal CO2 removal in comparison to noninvasive ventilation-only to prevent endotracheal intubation patients with acute hypercapnic respiratory failure at risk of failing noninvasive ventilation. Matched cohort study with historical control. Two academic Italian ICUs. Patients treated with noninvasive ventilation for acute hypercapnic respiratory ...
Kumar Abhay A Department of Neurology, Saint Louis University, Saint Louis, MO, - - 2014
Intracranial hemorrhage (ICH) is not an uncommon complication of end-stage renal disease (ESRD), and may be complicated by cerebral edema. Hemodialysis (HD) may induce rapid osmolar and fluid shifts, increasing brain water content with the potential to worsen cerebral edema. The dangers of HD in patients with acute ICH have ...
Yri Hanne M HM Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, - - 2014
The aims of this article are to characterize the headache in idiopathic intracranial hypertension (IIH) and to field-test the ICHD diagnostic criteria for headache attributed to IIH. We included 44 patients with new-onset IIH. Thirty-four patients with suspected but unconfirmed IIH served as controls. Headache and other IIH-related symptoms were ...
Coppola Gianluca G Department of Neurophysiology of Vision and Neurophthalmology, G.B. Bietti Foundation-IRCCS, Italy - - 2014
We previously observed impaired habituation mechanisms of the conventional blink reflex (BR) in patients with episodic cluster headache (ECH) during the bout, studying only the affected side. Here, we have studied the nociceptive-specific BR (nBR) both on the affected and non-affected sides, and in relation to clinical features. We recorded ...
Amirghofran Zahra Z Department of Immunology, Autoimmune Disease Research Center and Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, - - 2014
CD44v6 is an isoform of CD44 that can be present in soluble form (sCD44v6). The aim of this study is to evaluate the presence of soluble CD44 (sCD44) and sCD44v6 in serum of children with B-cell precursor acute lymphoblastic leukemia (B-ALL) and their relationship with prognosis. sCD44v6 and sCD44 levels ...
Hwang Minki M Division of Cardiology, Yonsei University Health System, Seoul, Republic of - - 2014
Although ventricular tachycardia/fibrillation (VT/VF) develops suddenly with catastrophic results, its prediction is limited. We tested the fibrillation number (FibN) for potential predictor of VT/VF using clinical data of implantable cardioverter-defibrillator (ICD) patients after validating the number by computational modeling. For clinical application of FibN, we used electrocardiography and echocardiography data: ...
Polak Paul E PE Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL 60612, - - 2014
Reduced levels of noradrenaline (NA) in CNS of multiple sclerosis patients could be due to metabolism by catechol-O-methyltransferase (COMT). In mice immunized with myelin oligodendrocyte glycoprotein peptide, the BBB-permeable COMT inhibitor dinitrocatechol (DNC) reduced clinical signs, while entacapone, a non-BBB-permeable inhibitor, had no effect. Spinal cord NA levels were slightly ...
Wheeler Hegland Karen K Department of Speech Language and Hearing Sciences, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA; Center for Movement Disorders and Neurorestoration, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address: - - 2014
Multiple airway protective mechanisms are impacted with Parkinson's disease (PD), including swallowing and cough. Cough serves to eject material from the lower airways, and can be produced voluntarily (on command) and reflexively in response to aspirate material or other airway irritants. Voluntary cough effectiveness is reduced in PD however it ...
Milan Marta M Department of Medicine, Vascular Medicine Unit, University Hospital of Padua, Padua, - - 2014
Whether there is an association between venous thromboembolism (VTE) and atherosclerosis is still controversial. In a case-control study conducted on subjects older than 50, we assessed the prevalence of symptomatic or subclinical atherosclerosis in a group of unselected patients with unprovoked VTE, and compared it with that of patients with ...
Imbach Lukas L LL Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland. Electronic address: - - 2014
Diagnosis and treatment of tremor are largely based on clinical assessment. Whereas in some patients tremor may respond to dopaminergic treatment, in general l-Dopa response to tremor varies considerably. The aim of this study was to predict l-Dopa response by accelerometry. We included 60 tremor patients and measured harmonic oscillations ...
Andrade Celi S CS Department of Radiology, Universidade de São Paulo, São Paulo, Brazil; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, - - 2014
Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that can characterize white matter (WM) architecture and microstructure. DTI has demonstrated extensive WM changes in patients with several epileptic syndromes, but few studies have focused on patients with malformations of cortical development (MCD). Our aim was to investigate ...
Zuidema M J MJ Department of Gastroenterology, St. Antonius Hospital Nieuwegein, The Netherlands. Electronic address: - - 2014
Acute pancreatitis has a highly variable clinical course. Early and reliable predictors for the severity of acute pancreatitis are lacking. Proteinuria appears to be a useful predictor of disease severity and outcome in a variety of clinical conditions. This study aims to investigate the predictive value of proteinuria on admission ...
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