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Results 451 - 500 of 3379
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Heble Daniel E DE Jr 1Department of Pharmacy, Children's Mercy Hospital, Kansas City, MO; 2Divison of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO; and 3University of Missouri-Kansas City School of Pharmacy, Kansas City, - - 2014
Metabolic alkalosis is a common acid-base disturbance occurring in critically ill pediatric patients. Acetazolamide and arginine hydrochloride are pharmacologic agents used at our institution for patients refractory to first-line therapy or those unable to tolerate fluid replacement. The objective of this retrospective review was to determine if a course of ...
van de Veerdonk Mariëlle C - - 2014
Even after years of stable response to therapy, patients with idiopathic pulmonary arterial hypertension (IPAH) may show an unexpected clinical deterioration due to progressive right ventricular (RV) failure. Therefore, the aim of this study was to assess in five-year clinically stable patients with IPAH whether initial differences or subsequent changes ...
Barlinn Kristian K Department of Neurology, Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama; Dresden University Stroke Center, Department of Neurology, University Hospital Carl Gustav Carus Dresden, University of Technology Dresden, Dresden, Germany. Electronic address: - - 2014
Peripheral arterial disease (PAD) is common in patients with acute cerebral ischemia. Indexes of resistance derived from the systolic and diastolic velocities are routinely used in diagnostic transcranial Doppler (TCD) to detect intracranial arterial disease. We sought to explore whether these indexes can predict the presence of PAD in acute ...
Calcagno A A Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, - - 2014
In limited-resource settings monitoring antiretroviral treatment efficacy is restrained by the lack of access to technological equipment. Aim of the study was to assess the use of dried plasma (DPS) and blood spots (DBS) to facilitate ARV monitoring in remote settings where clinical monitoring is the primary strategy. A cross-sectional ...
Hedenus Michael M Department of Internal Medicine, Sundsvall Hospital, 851 86, Sundsvall, Sweden, - - 2014
This randomized trial evaluated ferric carboxymaltose without erythropoiesis-stimulating agents (ESA) for correction of anemia in cancer patients with functional iron deficiency. Patients on treatment for indolent lymphoid malignancies, who had anemia [hemoglobin (Hb) 8.5-10.5 g/dL] and functional iron deficiency [transferrin saturation (TSAT) ≤20 %, ferritin >30 ng/mL (women) or >40 ng/mL (men)], were randomized ...
Bilgiç Ozlem O Department of Dermatology - - 2014
Abstract Background: Prior studies have demonstrated lower serum zinc levels in acne vulgaris (AV) patients compared with controls. However, no study has investigated the relationship between AV and erythrocyte zinc levels, which is a superior indicator of body zinc levels. Additionally, the potential influence of isotretinoin use on body zinc ...
Coutinho Jonathan M JM From the Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands (J.M.C., J.S.); Department of Neurology, Hospital Santa Maria, Lisboa, Portugal (P.C., J.M.F.); Department of Neurology, Instituto Nacional de Neurologia y Neurocirurgia, México City, México (F.B.); and Department of Neurology, Hôpital Lariboisière, Paris, France (M.-G.B.). - - 2014
Although headache is the most common symptom in cerebral venous thrombosis, 5% to 30% of patients do not report headache at baseline. Characteristics of these patients have not been investigated. In post hoc analysis of the International Study on Cerebral Vein and Dural Sinus Thrombosis study, patients who might not ...
Fabiá Valls M J - - 2014
Diagnostic management of suspected pulmonary embolism (PE) in patients with a history of venous thromboembolism (VTE) is complicated due to persistent abnormal D-dimer levels, residual embolic obstruction and higher clinical prediction rule (CPR) scores. We aimed to evaluate the safety and efficiency of the standard diagnostic algorithm consisting of a ...
Sun Wenxue W Department of Nephrology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, - - 2014
The purpose of this study was to investigate the correlation of conjunctival and corneal calcification (CCC) with cardiovascular calcification in patients undergoing maintenance hemodialysis (MHD). A total of 122 patients undergoing MHD in our hospital were included in this study. Conjunctival and corneal calcification was examined by slit lamp and ...
Haase Daniel D Department of Computer Science, Friedrich Schiller University, Jena, - - 2014
Aim of the present observational single center study was to objectively assess facial function in patients with idiopathic facial palsy with a new computer-based system that automatically recognizes action units (AUs) defined by the Facial Action Coding System (FACS). Still photographs using posed facial expressions of 28 healthy subjects and ...
Hasegawa Shunji S Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan. Electronic address: - - 2014
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disease characterized by opsoclonus, myoclonus, ataxia, and behavioral changes. The aim of our study was to investigate the epidemiological characteristics of OMS in Japan and to clarify the association between therapy and prognosis. We retrospectively collected the data from 626 Japanese medical institutions ...
de Beer Marlijn M From the Department of Neurology (M.d.B.), Haga Hospital, The Hague; the Department of Pediatric Neurology (M.E.), Emma Children's Hospital, Amsterdam; the Department of Neurology (M.E., B.M.v.G.), Academic Medical Center, University of Amsterdam; and the Department of Neurology (B.M.v.G.), Medical Center Alkmaar, the Netherlands. - - 2014
To study the frequency of additional cerebral demyelination in Dutch patients with adrenomyeloneuropathy (AMN). Consecutive patients with AMN from the Dutch X-linked adrenoleukodystrophy cohort without cerebral demyelination on MRI at inclusion, seen between January 1, 1992, and January 1, 1999, were included. Primary endpoints were brain involvement, death, or the ...
Sundareswaran Shobha - - 2014
Objectives :  The aims of this study were to analyze the prevalence of sella turcica bridging and to measure the size of the sella turcica on profile cephalograms in a homogenous group of surgically repaired unilateral cleft lip and palate (UCLP) patients. Setting :  Tertiary care center. Design :  Retrospective ...
Demir Abdurrahman A Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine , Istanbul , - - 2014
Abstract Objective. Familial Mediterranean fever (FMF) is the most common form of autoinflammatory diseases. We aimed to evaluate the small bowel mucosa by capsule endoscopy (CE) in FMF patients for investigation of other possible causes of abdominal pain. Material and methods. The study group consisted of 41 patients with FMF. ...
Kakisaka Keisuke K Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, - - 2014
The optimal conditions for hepatocyte proliferation should be clarified in an attempt to improve the impaired liver regeneration observed in patients with acute liver failure (ALF). In order to evaluate the significance of the serum AFP level and PT-INR as possible biomarkers of the proliferation of liver stem/progenitor cells (LPCs) ...
Domitrz Izabela I Department of Neurology, Medical University of Warsaw, Warsaw, - - 2014
A migraine is a common neurological disorder that often coexists with other illnesses including heart abnormalities, such as patent foramen ovale (PFO), atrial septal aneurysm (ASA), and mitral valve prolapse (MVP). The aim of our study was to evaluate the occurrence of some heart abnormalities in migraine patients by routine ...
Sauer Arnaud A Service d'Ophtalmologie, Centre Hospitalier Universitaire de Strasbourg, France. Institut de Parasitologie et de Pathologie Tropicale, EA 7292, Fédération de médecine Translationnelle, Université de Strasbourg, France. - - 2014
Uveitis is a potentially blinding inflammatory disease. 30-50% of uveitis cases are considered idiopathic. The present study sought to determine intraocular cytokine patterns in different etiological types of uveitis in order to better understand their immunological regulation and determine whether the cytokine pattern may be a useful diagnostic tool. From ...
Heckman Michael G MG From the Section of Biostatistics (M.G.H., N.N.D.) and Departments of Neuroscience (A.I.S.-O., S.R., K.O., M.E.M., D.W.D., O.A.R.) and Neurology (S.F., W.P.C., R.J.U., Z.K.W.), Mayo Clinic, Jacksonville, FL; Department of Molecular Neuroscience (L.S., A.S., H.H.), Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Department of Medical Genetics (M.J.F.), University of British Columbia, Vancouver, Canada; Laboratory of Neurogenetics (A.B.S.), National Institute on Aging, Bethesda, MD; Institute of Genetic Medicine (P.F.C., M.J.K.), Newcastle University, Central Parkway, Newcastle upon Tyne; Neuropathology Unit (S.M.G.), Department of Medicine, Imperial College London; Queen Square Brain Bank for Neurological Disorders (J.L.H., K.A.), Department of Molecular Neuroscience, UCL Institute of Neurology, University College London; Clinical and Cognitive Sciences Research Group (D.M.A.M.), Institute of Brain, Behavior and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford; and MRC London Neurodegenerative Diseases Brain Bank (S.A.-S., C.T.), King's College London, UK. - - 2014
The aim of this study was to evaluate the association between common exonic variants in the leucine-rich repeat kinase 2 (LRRK2) gene and risk of multiple system atrophy (MSA). One series from the United States (92 patients with pathologically confirmed MSA, 416 controls) and a second series from the United ...
Spencer Hillard T HT Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Hunnewell 2, Boston, MA, 02115, USA, - - 2014
Variation in rib numbering has been noted in adolescent idiopathic scoliosis (AIS), but its effect on the reporting of fusion levels has not been studied. We hypothesized that vertebral numbering variations can lead to differing documentation of fusion levels. We examined the radiographs of 161 surgical AIS patients and 179 ...
Kim Do Hoon DH Departments of Gastroenterology, Asan Digestive Disease Research Institute, University of Ulsan College of Medicine, Asan Medical Center , Seoul , - - 2014
Abstract Objectives. Patients with head and neck squamous cell carcinoma (HNSCC) often develop second primary tumors in the upper aerodigestive tract. Early detection of synchronous esophageal squamous cell neoplasm (ESCN) is important because the prognosis of HNSCC can be affected by the statuses of second primary tumors. Methods. In a ...
Li Jin-Feng - - 2014
Multiple sclerosis (MS) is a complex disease of neurological disability, affecting more than 300 out of every one million people in the world. The purpose of the study was to evaluate the therapeutic effects of human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation in MS patients. Twenty-three patients were enrolled ...
Bajuk Nataša Bedernjak NB Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, - - 2014
The impact of hyperthyroidism induced by Graves' disease (GD) on skin microcirculation has not been established. We aimed to assess vascular reactivity in hyperthyroid GD patients before and during treatment. Laser Doppler flux (LDF) was measured in 31 newly diagnosed hyperthyroid GD patients with an increased TSH receptor stimulating antibody ...
Choi Young Sik YS Y Choi, Seoul, Korea, Republic - - 2014
The aim of this study was to compare intrafollicular biomarkers of thiol-redox system and chronic inflammation in infertile patients with and without endometriosis and examine correlations between biomarkers and IVF outcomes. Sixty-five patients receiving IVF were included: 31 patients with endometriosis vs. 34 patients without endometriosis. Follicular fluid (FF) was ...
Alawami M M Green Lane Cardiovascular services, Auckland City Hospital, Auckland, New - - 2014
Obesity is a risk factor for both Sleep Related Breathing Disorders (SRBD) including Obesity Hypoventilation Syndrome (OHS) and Cardio-Vascular Diseases (CVD). The development of CVD in patients with SRBD is usually attributed to the fact that most patients are obese in addition to conventional cardiovascular risk factors. A dataset of ...
Hsiang J C JC Middlemore Hospital, Counties Manukau District Health Board, Otahuhu, Auckland, New - - 2014
Liver cirrhosis is an important cause of morbidity and mortality, however little is known about its impact in New Zealand. We aim to determine the disease burden, epidemiology and outcomes of cirrhotic patients METHODS: A retrospective study of patients with cirrhosis who sought care at a sole public hospital in ...
Cioffi Giovanni G Department of Cardiology, Villa Bianca Hospital, Trento, - - 2014
Early detection of left ventricular (LV) systolic dysfunction is pivotal in the management of patients with aortic stenosis (AS). LV circumferential and/or longitudinal shortening may be impaired in these patients despite LV ejection fraction is preserved. We focused on prevalence and factors associated with combined impairment of circumferential and longitudinal ...
He Wei W Department of Physical Medicine and Rehabilitation, The Affiliated Jiangyin People's Hospital of Southeast University Medical College, Wuxi, - - 2014
We conducted a meta-analysis of positron emission tomography (PET) findings in Alzheimer's disease (AD) and mild cognitive impairment (MCI) to clarify the changes underpinning these conditions. All studies that utilised the PET tracers Pittsburgh Compound-B (PIB) or 2-[18F]fluoro-2-deoxy-D-glucose (FDG) to investigate patients with MCI or AD, were considered for the ...
Daniłowicz-Szymanowicz Ludmiła L Department of Cardiology and Electrotherapy, Medical University of Gdańsk. - - 2014
Patients with left ventricular ejection fraction (LVEF) ≤ 35% are eligible for implantable cardioverter-defibrillator (ICD) placement for the primary prevention of sudden cardiac death (SCD). This recommendation results in continuously growing waiting lists of patients who have been qualified for and are awaiting the procedure. Whiled reduced LVEF is a ...
Kamiya Kinji K Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, - - 2014
Reconstruction with free jejunal graft (FJG) is often performed for patients with hypopharyngeal or cervical esophageal cancer. During reconstruction with an FJG after pharyngoesophagectomy, it is critical to intraoperatively detect venous anastomotic failure and subsequent venous malperfusion to avoid postoperative FJG necrosis. This study introduces a novel method for assessing ...
Zampetti Anna A Department of Dermatology, Policlinico A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Dermatology, Barts NHS (National Health System) Trust, London, United Kingdom. Electronic address: - - 2014
Myotonic dystrophy type 1 (MD1) is reported to be associated with internal malignancies. The association of myotonic dystrophy with cutaneous tumors is not fully understood. We sought to explore the total nevi count and the presence of atypical nevi, cutaneous melanoma, and other skin neoplasms in a representative cohort of ...
Caviglia Gian Paolo GP Department of Medical Sciences, University of Turin , Turin , - - 2014
Abstract Background. The clinical pictures of functional gastrointestinal disorders and inflammatory diseases can be quite similar leading to inappropriate and expensive investigations. Objective. To investigate fecal calprotectin (FC) diagnostic performance in different gastrointestinal conditions. Material and methods. Stool specimens of 66 outpatients referred for colonoscopy were collected for further FC ...
Tsourdi Elena - - 2014
Alemtuzumab, a humanized monoclonal antibody against CD52, is effective in the treatment of early relapsing-remitting multiple sclerosis (MS). Common adverse effects include an acute-phase reaction, infections and autoimmune diseases, including thyroid disorders. Patients from two phase 3 trials (CARE MS 1 and 2, n=15) were studied in a clinical research ...
Richards Anthony A Sydney Gynaecology Oncology Group, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, - - 2014
To determine the effectiveness of vaginal estrogen cream to improve the rate of satisfactory colposcopy and subsequent smear result in patients in a hypoestrogenic state and an abnormal Papanicolaou smear. To delineate between abnormal smears secondary to atrophy and inflammation from preneoplastic change and suggest an effective treatment strategy to ...
Hong Hong H Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio; Case Western Reserve University School of Medicine, Cleveland, - - 2014
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening diagnosis requiring prompt initiation of therapeutic plasma exchange (TPE). Measurement of immature platelet (PLT) fraction (%-IPF) differentiates PLT consumption or destruction from hypoproduction. Our study evaluated %-IPF changes over the course of TTP treated with TPE and as a measure of treatment efficacy. ...
Aulagnon Florence F Medical Intensive Care Unit, Saint-Louis Hospital, Assistance Publique-Hopitaux de Paris, and Paris Diderot University, Paris, - - 2014
Acute kidney injury (AKI) in the setting of hemophagocytic lymphohistiocytosis (HLH) is poorly characterized. This study aims to describe the incidence, clinical and biological features, and outcome associated with AKI in this population. Case series. Patients with secondary HLH admitted to a single center from February 2007 through January 2013. ...
Romijn Marloes D M MD Department of Geriatric Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Geriatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The - - 2014
In dialysis-dependent and severe chronic kidney disease (CKD) patients, cognitive impairment is found in 16-29%. In community-dwelling population without dementia mixed results have been observed. We investigated the relationship between renal function and cognition in patients from a memory clinic. We performed a cross-sectional study of consecutive patients from a ...
Torp-Pedersen S Ren SR The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Frederiksberg, Denmark; Deparment of Diagnostics, Radiology Section, Copenhagen University Hospital at Glostrup, - - 2014
Objectives: To determine how settings for power and color Doppler sensitivity varies on different high and intermediate range ultrasound (US) machines and to evaluate the impact of these changes on Doppler scoring of inflammatory joints Methods: Six different types of ultrasound machine were used. On each machine, the factory setting ...
Sueda Shozo S Department of Cardiology, Ehime Niihama Prefectural Hospital, Hongou 3 choume 1-1, Niihama City, Ehime Prefecture, 792-0042, Japan, - - 2014
In the clinical grounds, patients with ≥90 % luminal narrowing during acetylcholine (ACh) testing had variable response. We investigated ischemic findings and chest symptoms in patients with ≥90 % luminal narrowing when performing ACh tests, retrospectively. We performed 763 ACh tests over 13 years (2001-2013). We analyzed chest symptoms and positive ischemic ECG ...
Hegele Axel - - 2014
The causality of overactive bladder syndrome (OAB) is still not fully understood. Several studies indicate a significant increase of prostaglandin E2 (PGE2) in patients with OAB. However, in order to clarify whether these compounds can help to objectify the clinical diagnosis, further studies are needed. This prospective study aims to ...
Cho Shih-Feng - - 2014
The pathogenesis of multiple myeloma involves complex genetic and epigenetic events. This study aimed to investigate the role and clinical relevance of the long non-coding RNA (lncRNA), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in multiple myeloma. Bone marrow mononuclear cells were collected for analysis. The samples of multiple myeloma were ...
Siwiec R M RM Division of Gastroenterology & Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, - - 2014
The insula plays a significant role in the interoceptive processing of visceral stimuli. We have previously shown that gastroesophageal reflux disease (GERD) patients have increased insular cortex activity during esophageal stimulation, suggesting a sensitized esophago-cortical neuraxis. However, information regarding the functional connectivity (FC) of the insula during visceral stimulation is ...
Desai Shilpa J SJ Department of Ophthalmology, University of California, San Francisco, San Francisco, - - 2014
To describe a newly recognized clinical syndrome consisting of ptosis, diplopia, vertical gaze limitation, and abduction weakness that can occur after orbital roof removal during orbito-zygomatic-pterional craniotomy. Case series. Eight study patients (7 women), 44 to 80 years of age, with neuro-ophthalmic symptoms after pterional craniotomy. Case description of 8 ...
Haji Kavi K Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia. Electronic address: - - 2014
The objectives of the study are to identify the most reliably imaged regions of the diaphragm, to evaluate the correlation of movement between different parts of each hemidiaphragm, and to assess the agreement between liver or spleen displacement and movement of the ipsilateral hemidiaphragm. Images of the diaphragm, liver, and ...
Chien Yin-Hsiu YH Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Hospital, Taipei, - - 2014
To determine the benefit of newborn screening for the long-term prognosis of patients with classic infantile-onset Pompe disease (IOPD). A cohort of patients with classic IOPD were diagnosed by newborn screening, treated with recombinant human acid α-glucosidase (rhGAA), and followed prospectively. Outcome measurements included survival, left ventricular mass, serum creatinine ...
Qian Biao B Department of Urology, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832003, P.R. - - 2015
The aim of the present study was to investigate the correlation between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of urolithiasis and dyslipidemia. A total of 180 Uyghur individuals, including 90 urolithiasis patients and 90 healthy controls, were enrolled in this study. The blood lipid profiles of the patients ...
Ward Michael M MM Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of - - 2014
Objective: The patient global assessment (PGA) is intended to provide an integrated summary of all symptoms of arthritis, but it is not clear which disease features most impact patients' assessments of changes in their overall status. We investigated what aspects of rheumatoid arthritis (RA) activity correlated best with prospectively measured ...
Goulis Ioannis I Department of Internal Medicine, Αristotle University of Thessaloniki Medical School, Hippokration General Hospital, Thessaloniki, - - 2014
We assessed predictors of response in HBeAg-negative chronic hepatitis B patients treated with peginterferonalfa-2a in routine clinical practice. Ninety-five HBeAg-negative patients receivedpeginterferonalfa-2a for 48 weeks and were followed-up for 48 weeks post-treatment. Serum HBsAg and HBV DNA levels were monitored during and after therapy with valid commercial assays. Sustained response ...
Altunoğlu Alpaslan A Department of Nephrology, Ataturk Education and Research Hospital, Bilkent-Ankara, - - 2014
We aimed to investigate serum cystatin C (cysC) levels in primary Sjögren's syndrome (pSS) patients, and evaluate its correlation with renal involment. Eighty-six pSS patients and 65 age- and gender-matched healthy controls were enrolled into the study. Serum cysC, urea, serum creatinine (SCr), creatinine clearance (CrCl), glomerular filtration rates (GFR), ...
Schewel Dimitry D Division of Cardiology, ASKLEPIOS Clinics St. Georg Hospital, Lohmühlenstr. 5, 20099, Hamburg, Germany, - - 2014
Transcatheter aortic valve implantation (TAVI) is a proven alternative to open heart surgery in elderly patients. Pulmonary hypertension (PH) is known as a significant risk factor in patients with severe aortic stenosis (AS) undergoing surgical aortic valve replacement. However, the prognostic impact of PH in high-risk patients undergoing TAVI is ...
AlSaleem Alhanouf A Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Po Box 3354, Riyadh, 11211, Saudi - - 2014
To assess serum 25-hydroxyvitamin D (25-OH vitamin D) status in Saudi children with systemic lupus erythematosus (SLE) and determined its association with clinical, laboratory variables and disease activity. This cross-sectional study comprised children with SLE who are followed at Pediatric Lupus Clinic. All patients reviewed for demographic data, age of ...
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