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Lim Jun Uk JU Department of Gastroenterology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, - - 2014
Although current guideline recommends selective use of pre-endoscopic prokinetics to increase diagnostic yield in upper gastrointestinal bleeding (UGIB) patients, no data to guide the use of these drugs are available. We aimed to investigate predictive factors for endoscopic visibility and develop simple and useful strategies for pre-endoscopic prokinetics use in ...
Kang Yun-Seong YS Department of Internal Medicine, College of Medicine, Dongguk University Ilsan Hospital, Goyang, 410-773, Republic of - - 2014
CT-P13 is the first biosimilar monoclonal antibody to infliximab. However, the antibody was tested only in rheumatoid arthritis and ankylosing spondylitis, which demonstrated equivalence to the originator in efficacy, safety, and pharmacokinetic profile. Extrapolation of its efficacy and safety to other pathologies is tenuous. Interchangeability with its originator is another ...
Zhang Ruijie R Department of Medical Imaging, Jinan Military General Hospital, No.25, Shifan Road, Jinan, Shandong Province, China, - - 2014
The purpose of this investigation was to examine the association between cognition disorders and microstructural white matter (WM) changes in maintenance hemodialysis end-stage renal disease (ESRD) patients. Twenty-six maintenance hemodialysis ESRD patients and 28 healthy controls underwent diffusion tensor imaging (DTI), Mini Mental State Examination (MMSE), Trial Marking Test-A&B (TMT-A&B), ...
Yoshida Yuko Y Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, - - 2014
Although preoperative biliary drainage in jaundiced patients is controversial, external biliary drainage (EBD) is beneficial for infection control in patients with biliary cancers. When EBD is performed, additional bile replacement (BR) has the benefit of improving impaired intestinal barrier function, but the detailed mechanism remains unknown. We examined the effect ...
Vearrier David D Department of Emergency Medicine, Drexel University College of Medicine, 245 N. 15th St, Mail Stop 1011, Philadelphia, PA, 19102, USA, - - 2014
Phenol is a caustic that may cause cutaneous or gastrointestinal burns depending on the route of exposure. Significant absorption may result in systemic toxicity. We present a case of topical phenol exposure resulting in cutaneous burns and systemic phenol toxicity. A 9-year-old girl was exposed to Creolin®, a general-purpose disinfectant ...
Manfredi A A Rheumatology Unit, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41121, Modena, Italy, - - 2014
Inflammatory myopathies (IM) are a group of muscle diseases occurring both in children and adults. Nailfold videocapillaroscopy (NVC) alterations are described in IM, but available data are discordant, including differences between polymyositis (PM) and dermatomyositis (DM). The aim of this study was to describe the capillaroscopic differences between PM and ...
Shoda Katsutoshi K Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramach Hirokoji Kajiicho, Kamigyo-ku, Kyoto, 602-8566, - - 2014
We used real-time quantitative polymerase chain reaction (rqPCR) to detect human epidermal growth factor receptor 2 (HER2) amplification in the circulating cell-free DNA (cfDNA) of patients with gastric cancer (GC), which shows the spatial and temporal intrinsic heterogeneity of HER2 expression/copy number during progression, for liquid biopsy and treatment monitoring. ...
Wagenmakers Maem M Department of Medicine, Division of Endocrinology, Radboud University Medical Centre, Geert Grooteplein 8, 6500 HB, Nijmegen, the - - 2014
Centripetal obesity is associated with systemic low-grade inflammation and an increased cardiovascular risk. Patients in long-term remission of Cushing's syndrome (CS) report persisting abdominal fat accumulation. However, this has previously not been adequately objectified. Therefore we investigated the adipose tissue distribution and adipocytokine profiles of patients in long-term remission of ...
Reibis Rona R Department of Cardiology, Klinik am See, Rüdersdorf, - - 2014
Abstract Background. We aimed to describe the contemporary management of patients with systolic chronic heart failure (CHF) during a cardiac rehabilitation (CR) stay and present outcomes with focus on lipids, blood pressure, exercise capacity, and clinical events. Methods. Comparison of 3,199 patients with moderately or severely impaired left ventricular ejection ...
Rak Michael M Max-Plank-Institute of Psychiatry, Munich, - - 2014
Nightmares are a frequent symptom in narcolepsy. Lucid dreaming, i.e., the phenomenon of becoming aware of the dreaming state during dreaming, has been demonstrated to be of therapeutic value for recurrent nightmares. Data on lucid dreaming in narcolepsy patients, however, is sparse. The aim of this study was to evaluate ...
Thunström Erik E Department of Molecular and Clinical Medicine, Institution of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2014
Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD). Enhanced vascular inflammation is implicated as a pathophysiologic mechanism but obesity is confounding. We aimed to address the association of OSA with inflammatory biomarkers in a nonobese cohort of revascularized patients with CAD and preserved left ventricular ...
Truin W W Department of Surgery, Máxima Medical Centre, Veldhoven, The Netherlands, - - 2014
The aim of this study was to compare the frequency of breast-conserving surgery (BCS) between early-stage invasive ductal (IDC) and invasive lobular breast cancer (ILC). Women with primary non-metastatic pT1 and pT2 IDC or ILC diagnosed between 1990 and 2010 were selected from the NCR. All patients underwent BCS or ...
Matsuba Yumiko Y Hals-, Nasen-, Ohrenklinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, - - 2014
To evaluate the clinical course of orbital complication using a standardised diagnostic pathway. Seventy-three patients with orbital complications underwent a multimodal diagnostic pathway comprising ENT examination, leucocytes/CRP, CT-/MRI-scanning and disease-related data. Twenty-nine patients suffered from rhinosinusitis, 28 from mucoceles, 13 patients from neoplasms and three patients from rheumatic disorders. Clinical ...
Akudugu John J Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa, - - 2014
To assay for uPA and PAI-1 in prostate tissue from 40 patients with prostatic disease and to examine the robustness of the correlation of the uPA/PAI-1 ratio with benign prostatic hyperplasia (BPH) and prostate cancer (PCa), previously identified in a different cohort of 62 patients. uPA and PAI-1 were extracted ...
Raouf Alaa A Department of Neurosurgery, Faculty of Medicine, Alexandria University, Champillion St., Elazaritta, Alexandria, - - 2014
Hydrocephalus is a very common disease in developing countries. Congenital aqueductal obstruction and post-inflammatory hydrocephalus come on the top of the list of causes of hydrocephalus. Till the recent introduction of cranial endoscopy and despite their frequent complications, shunts were considered as the mainstream treatment for this disease. Endoscopic third ...
Tremolaterra Fabrizio - - 2014
Fibromyalgia Syndrome (FMS) is a frequent comorbidity in Irritable Bowel Syndrome (IBS) patients with a higher functional bowel disorder severity index (FBDSI). We tested the possibility that mild to severe IBS patients without FMS would have a graduated visceral and somatic perception, and the presence of FMS would further enhance ...
Aghaebrahim Amin A Department of Neurology, Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, - - 2014
Previous studies have suggested that patients with wake-up stroke (WUS) may have superior outcomes compared with patients with a witnessed late time of onset after revascularization. We sought to test this hypothesis in patients with anterior circulation large vessel occlusion stroke (ACLVOS) treated with endovascular therapy beyond 8 h from time ...
Boltin Doron - - 2014
BackgroundRifaximin is a minimally absorbed antibiotic with high luminal activity, used to treat various gastrointestinal diseases. Although rifaximin has been proposed as first line treatment for small intestinal bacterial overgrowth (SIBO), few data are available regarding its efficacy in non-IBS subjects. We aimed to assess the ability of rifaximin to ...
Guinot Pierre-Grégoire PG From the Anaesthesiology and Critical Care Department, Amiens University Hospital, Place Victor Pauchet, Amiens, - - 2014
The ability to predict fluid responsiveness in spontaneously breathing patients under spinal anaesthesia is desirable. The objective of this study was to test whether variations in stroke volume (SV) in response to a fixed mini-fluid challenge (ΔSV100) measured by thoracic impedance cardiography (ICG) can predict fluid responsiveness in spontaneously breathing ...
Abdallah J J Division of Gastroenterology and Hepatology, The Esophageal and Swallowing Center, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, - - 2014
Length of Barrett's oesophagus (BE) is a risk factor for oesophageal cancer. The underlying mechanisms that determine BE length are not fully known. To determine if there is a correlation between obesity and length of BE. Using a population-based study, 381 patients diagnosed with Barrett's oesophagus between 1999 and 2013 ...
Kim Seok-Mo SM Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, - - 2014
Background. This study aimed to investigate the outcomes of papillary thyroid cancer (PTC) patients with lateral neck metastasis (LNM) according to their permanent pathology report but negative frozen section findings who did not undergo lateral neck dissection (LND). Methods. Between September 2009 and December 2011, 575 patients at Gangnam Severance ...
Silva Alessandra Pawelec da AP Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, - - 2014
Oculo-auriculo-vertebral spectrum (OAVS) is considered to be a defect of embryogenesis involving structures originating from the first branchial arches. Our objective was to describe the clinical and cytogenetic findings from a sample of patients with the phenotype of OAVS. Cross-sectional study in a referral hospital in southern Brazil. The sample ...
Ho Li-Chun LC Division of Nephrology, Department of Internal Medicine, E-DA Hospital, Kaohsiung, - - 2014
Background: High serum cystatin C (CysC) has been associated with clinical risks independently of the glomerular filtration rate (GFR). This study aims to investigate the predictive power of CysC in patients with a negligible GFR. Methods: Patients on chronic hemodialysis or peritoneal dialysis were enrolled for measurement of CysC levels ...
Al-Hakeim Hussein Kadhem HK Department of Chemistry, College of Science, Kufa University, Najaf 221, - - 2014
Thalassemia patients are at high risk of iron-induced toxicity and oxidative stress consequences. The present cross-sectional study is conducted to determine whether or not lipid peroxidation or protein oxidation is correlated with iron parameters in patients with thalassemia major. To prove this hypothesis, malondialdehyde and total carbonyl were correlated with ...
Sato Eiichi E Department of Pathology, Dokkyo Medical University, Koshigaya - - 2014
The efficacy of tolvaptan for treating heart failure has already been shown. Adequate data relating to the effect of tolvaptan on the correlation of water balance in renal disease are not available. A retrospective study was conducted on the efficacy and adverse reactions of tolvaptan for treating nephrotic syndrome.The subjects ...
Takada Jun J Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan, - - 2014
Carbon dioxide (CO2) insufflation is effective for gastric endoscopic submucosal dissection (ESD). However, its safety is unknown in patients with pulmonary dysfunction. This study aimed to investigate the safety of CO2 insufflation during gastric ESD in patients with pulmonary dysfunction under conscious sedation. We analyzed 322 consecutive patients undergoing ESD ...
Fawzi Amani A AA Department of - - 2014
Our objective was to present clinicopathologic evidence of anterior visual pathway involvement in patients with amyotrophic lateral sclerosis (ALS) secondary to a C9orf72 mutation. Two related patients from an extended pedigree with ALS and GGGGCC hexanucleotide repeat expansion in the C9orf72 gene (C9-ALS) underwent neuro-ophthalmologic examination. Following death and tissue ...
Lupoli Ga G Department of Clinical Medicine and Surgery, University "Federico II", Via Pansini 5, 80131, Naples, - - 2014
Context: Thyroglobulin antibodies (TgAbs) are surrogate markers of disease recurrence or persistence in differentiated thyroid cancer (DTC). However the prognostic significance of TgAb heterogeneity in DTC has not been investigated. Objective: To evaluate the relationship between TgAb epitope specificities and clinical outcomes in DTC patients. Design: We studied 61 TgAb-positive ...
Siddique Iqbal I Department of Medicine, Faculty of Medicine, Kuwait University , Safat , - - 2014
Abstract Objective. Ulcerative colitis (UC) is generally considered a disease of the Caucasian populations in developed countries, but its incidence is increasing rapidly in many developing countries, including the Middle East. The objective of this study was to determine the clinical epidemiology of UC in Arabs. Material and methods. This ...
Hansen C K CK Department of Neurology, Bispebjerg University Hospital, Copenhagen, - - 2014
The frequency of acute large vessel occlusions in relation to clinical severity has not yet been established in a comprehensive, consecutive and unselected cohort of patients with hyper-acute cerebral ischemia. The aim of this study was to establish the frequency of acute large vessel occlusions and describe the relations to ...
Campello E - - 2014
The role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in overweight and obese patients with and without metabolic syndrome is still a matter of debate. In a case-control study, the presence of hypercoagulability was evaluated in overweight and obese patients by measuring MP, thrombin generation (TG) ...
Pool Joan J Joan Pool, RN, MSE, BSN, CCRN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Margaret Dercher, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Belinda Hanson, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Linda Heiman, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Yan Li, MA Biostatistician, Saint Luke's Hospital of Kansas City, Missouri. Kim Schraeder, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Mary Pat Schultz, APRN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Shawna Ziglinski, RN, BSN Staff Nurse, Cardiovascular Recovery Unit and Cardiovascular Holding Unit, Saint Luke's Hospital of Kansas City, Missouri. Marci Ebberts, RN, BSN, CCRN Clinical Education Specialist, Saint Luke's Hospital of Kansas City, - - 2014
Maintaining patient comfort and avoiding complications after coronary angiography are important both to the patient and the nurse. Strict bed rest with the head of bed (HOB) completely flat is standard care for postprocedure positioning to decrease pressure on the femoral artery. This position is not thought to be the ...
Park Hee Kyung HK Department of Neurology, Inje University Ilsan Paik Hospital, Goyang, - - 2014
Background & Objective: Early-onset Alzheimer's disease (EOAD, onset age <65 years) may differ from late-onset Alzheimer's disease (LOAD) in terms of cognitive profiles and neuropsychiatric symptoms. There have been few studies for Korean EOAD patients using well-structured databases. Previous studies focusing on cognitive profiles between the two groups had a ...
Gonzalez-Duarte Alejandra - - 2014
Background: Cryptococcal meningitis (CM) is a rare condition in non-HIV patients. The clinical manifestations in patients with systemic lupus erythematosus (SLE) are often confused with immunological activity, resulting in delayed diagnosis. Aims: We describe the natural history and outcome of eight HIV-negative patients with SLE and confirmed CM. Results: Mean ...
Savale Laurent L Université Paris-Sud, Faculté de Médecine, Le Kremlin Bicêtre, France AP-HP, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire (DHU) Thorax Innovation (TORINO), Service de Pneumologie, Hôpital de Bicêtre, Le Kremlin Bicêtre, France UMR_S 999, INSERM, Laboratoire d'Excellence (LabEx) en Recherche sur le Médicament et l'Innovation Thérapeutique (LERMIT), Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France - - 2014
Isolated cases of pulmonary arterial hypertension (PAH) in patients treated with interferon (IFN) α or β have been reported in the literature. The aim of this study was to describe all consecutive cases of PAH patients with a history of IFN exposure identified in the French reference centre for severe ...
Kemna Michael J MJ Clinical and Experimental Immunology and Cardiovascular Research Institute Maastricht - - 2014
The value of measuring ANCA during follow-up to predict a relapse is controversial. On the basis of recently obtained pathophysiologic insights, we postulated that measuring ANCA is useful in patients with renal involvement but is less valuable in patients with nonrenal disease. One hundred sixty-six consecutive patients with ANCA-associated vasculitis, ...
Diener Hans-Christoph HC Department of Neurology and Headache Center, University Hospital Essen, Germany - - 2014
Numerous studies have described a relationship between migraine and stroke, and there is emerging evidence that migraine is also associated with cardiovascular disease. The combination of migraine and both cerebrovascular and cardiovascular disease has implications for therapy. We conducted a review of the modifications in medical therapy in patients with ...
Purrucker Jan C JC Department of Neurology, Heidelberg University Hospital, Heidelberg, - - 2014
Background: In patients presenting with acute vertigo or dizziness, identifying the posterior fossa stroke as the underlying cause can be a major challenge. We therefore evaluated the serum biomarkers for the differential diagnosis of nonvascular vertigo and posterior circulation stroke. Methods: Of a total of 80 patients, 31 patients had ...
Kuittinen Pekka - - 2014
Lumbar spinal stenosis (LSS) is the common term used to describe patients with symptoms related to the anatomical reduction of the lumbar spinal canal size. However, some subjects may have a markedly narrowed canal without any symptoms. This raises the question of what is the actual role of central canal ...
Evangelopoulos Maria-Eleptheria ME Demyelinating Diseases Unit, Department of Neurology, University of Athens, Eginition Hospital, Athens, - - 2015
Natalizumab (NTM) represents an effective drug for the treatment of relapsing-remitting multiple sclerosis (RRMS). Progressive multifocal leucoencephalopathy (PML) is a potential life-threatening complication of NTM treatment. A close follow-up and MRI monitoring of patients under NTM are required to avoid such devastating complications. The case of a 47-year-old woman with ...
Florian Anca A Department of Cardiology and Angiology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, - - 2014
Cardiovascular magnetic resonance (CMR) has become a valuable diagnostic tool for non-invasive diagnosis of acute myocarditis. However, since CMR studies are time- and cost-intensive and its diagnostic accuracy still not perfect, additional parameters are warranted to preselect and identify those individuals in whom a CMR study is likely to add ...
Shah Nimish N Department of Gastroenterology, Jagjivan Ram Hospital, Maratha Mandir Marg, Mumbai, 400 008, India, - - 2014
Constipation may be primary or secondary. Pathophysiologic subtypes of primary constipation are dyssynergic defecation (DD), slow (STC), and normal transit constipation (NTC). Clinical subtypes are functional constipation (FC) and constipation predominant IBS (C-IBS). The objectives of this paper are to study the clinical profile, categorize and compare various subtypes of ...
Moufarrej Mira Noura MN Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA, - - 2014
To better understand the factors that affect low disease activity (DAS28 ≤ 3.2, LDA) in rheumatoid arthritis (RA) and barriers within the UAE, demographic/treatment data and DAS28 scores were collected through chart reviews of 182 consecutive RA patients seen at a private clinic in Dubai over a 2-month period. Patients were separated ...
Franeková J J Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. - - 2014
C-reactive protein (CRP) is a marker of arterial inflammation while lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is related to plaque instability. The aim of this study was to evaluate the correlation between the risk of unstable plaque presenting as acute coronary syndrome (ACS) and Lp-PLA(2), and to assess the influence of statins ...
Nardo Alice A Motion Analysis Laboratory, IRCCS Istituto Ortopedico Galeazzi, Milano, - - 2014
Despite Deep Brain Stimulation (DBS) improves cardinal symptoms of Parkinson's Disease (PD), its effect on walking impairment is less evident. Robotic-assisted rehabilitation systems could serve as "add-on" physical therapy for PD patients. This systems are able to anticipate and correct the trajectory of patients' motion to improve their motor function ...
Li Furong F National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, - - 2014
Soluble urokinase plasminogen activator receptor (suPAR) was initially proposed as a pathogenic and predictive biomarker of primary FSGS, but the findings were controversial. This study aimed to clarify the clinical implications of suPAR. The study enrolled 109 patients with biopsy-proven primary FSGS who were administered prednisone between January 2011 and ...
Liu Guobing G Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, PR - - 2014
The efficacy of susceptibility-weighted imaging (SWI) for detecting intracranial bleeds (ICBs) in patients with mild traumatic brain injury (MTBI) has not been directly compared to that of T2*-weighted gradient-recalled-echo imaging (T2*WI). Further, its prognostic value for MTBI patients remains unproven. To compare the sensitivity of ICB identification between SWI and ...
van der Zee Anneke A Maasstad Laboratory, Molecular Diagnostics Unit, Maasstadweg 21, 3079DZ Rotterdam, The Netherlands. - - 2014
In an outbreak setting we screened 16296 samples from 3644 patients by PCR for the presence of blaOXA-48, blaVIM, blaIMP, blaNDM, blaKPC. The gene for blaOXA-48 was found in 43 patients en in 9 different species of Enterobacteriaceae. Five patients had Pseudomonas aeruginosa containing blaVIM. The negative predictive value of ...
Zhao Fujie F Departments of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, P. R. of - - 2014
BACKGROUND AND PURPOSE: It is unclear whether nicorandil, a metabolic therapeutic drug, can be applied clinically to therapy of heart failure (HF). This meta-analysis evaluated therapeutic effects of nicorandil on HF patients. EXPERIMENTAL APPROACH: We performed a systematic review and meta-analysis of published studies evaluating effect of nicorandil on HF patients. Studies were ...
Etz Christian D CD Department of Cardiac Surgery, University of Leipzig, Heart Center Leipzig, Leipzig, - - 2014
The aim of this study is to investigate the clinical characteristics and postoperative outcome of patients with a bicuspid aortic valve (BAV) suffering acute dissection in comparison with their tricuspid peers. Between 1995 and 2011, 460 consecutive patients underwent emergency repair for acute type A aortic dissection. In 379 patients ...
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