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Uhle Florian F From the Departments of Anaesthesiology and Intensive Care Medicine (F.U., D.V.D.N., S.L., T.M., S.W., M.A.W., C.L.), and Trauma Surgery (G.S., R.S.), Justus-Liebig-University, Giessen; and Department of Orthopaedic and Trauma Surgery (J.F.), Elbeklinikum, Stade, - - 2014
Life-threatening traumatic injuries lead to a complex inflammation-driven pathophysiology. Receptor of advanced glycation end product (RAGE) is a multiligand receptor of several endogenous alarmins, while cytokeratin 18 is a structural component of the filament of epithelial cells. Both proteins can be frequently found in plasma of patients with different diseases, ...
Chan Joshua L JL Department of Surgery, Division of Trauma and Critical Care, Cedars-Sinai Medical Center, Los Angeles, California, - - 2014
Patients sustaining traumatic injuries are at risk for development of rhabdomyolysis. The effect of obesity on this risk is unknown. This study attempted to characterize the role of obesity in the development of rhabdomyolysis after trauma. This was a retrospective review of all trauma patients with creatine kinase (CK) levels ...
Liou Douglas Z DZ Department of Surgery, Division of Trauma and Critical Care, Cedars-Sinai Medical Center, Los Angeles, California, - - 2014
Early trauma-induced coagulopathy (ETIC) is abnormal coagulation detected on presentation, but a clear description is lacking. We used thromboelastography (TEG) to characterize ETIC. Data were prospectively collected on high-acuity trauma activations at an urban Level I trauma center between July 2012 and May 2013. Patients with admission TEG before any ...
Baschera Dominik D Bern University Hospital, Neurosurgery , Freiburgstrasse , Bern, Switzerland, 3008 ; - - 2014
The association between helmet use during alpine skiing and incidence and severity of head injuries was analyzed. All patients admitted to a level 1 trauma center for traumatic brain injuries (TBI) sustained due to skiing accidents during the seasons 2000/01-2010/11 were eligible. Primary outcome was the association between helmet use ...
Suehiro Eiichi E M D Ph D Yamaguchi University School of Medicine, Neurosurgery, Ube, Yamaguchi, Japan ; - - 2014
A multicenter randomized controlled trial of patients with severe traumatic brain injury who received therapeutic hypothermia or fever control was performed from 2002 to 2008 in Japan (BHYPO). There was no difference in the therapeutic effect on traumatic brain injury between the two groups. The efficacy of hypothermia treatment, and ...
Parr Sharidan K SK Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, - - 2014
Biomarker studies for early detection of acute kidney injury (AKI) have been limited by nonselective testing and uncertainties in using small changes in serum creatinine as a reference standard. Here we examine the ability of urine L-type fatty acid-binding protein (L-FABP), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and kidney injury ...
Skinner D L DL Department of Critical Care, King Edward VIII Hospital, P/Bag X02 Congella 4013, Durban, KwaZulu-Natal 4083, South Africa; Perioperative Research Group, Department of Anaesthetics & Critical Care, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: - - 2014
This study describes the incidence and outcomes of blunt cardiac injury (BCI) in a single trauma intensive care unit (TICU), together with the spectrum of thoracic injuries and cardiac abnormalities seen in BCI. We performed a retrospective observational study of 169 patients with blunt thoracic trauma admitted from January 2010 ...
Claassen Jan J Division of Critical Care Neurology and Comprehensive Epilepsy Center, College of Physicians and Surgeons, Neurological Institute, Columbia University, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA, - - 2014
To determine the optimal use and indications of electroencephalography (EEG) in critical care management of acute brain injury (ABI). An electronic literature search was conducted for articles in English describing electrophysiological monitoring in ABI from January 1990 to August 2013. A total of 165 studies were included. EEG is a ...
Harkey Matthew S MS Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, Chapel Hill NC. Electronic address: - - 2014
There is an increased risk of developing knee osteoarthritis (OA) following anterior cruciate ligament (ACL) injury. Biomarkers may provide diagnostic, prognostic, or burden of disease indicators of OA before radiographic changes become apparent. Unfortunately, there has been no systematic review to clarify which biomarkers may be most informative following injury. ...
Feucht Matthias J MJ Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Hugstetter Straße 55, 79016, Freiburg, Germany, - - 2014
To identify risk factors for posterior lateral meniscus root tears (PLRT) in patients with a tear of the anterior cruciate ligament (ACL). A database of 268 patients undergoing primary ACL reconstruction between 2011 and 2013 was used to identify all patients with isolated ACL tears and patients with an associated ...
Cotter Maura Brid MB Histopathology Department, St Vincent's University Hospital, Elm Park, Dublin - - 2014
Introduction: Diarrhoea following orthotopic liver transplantation (OLT) is a significant clinical problem associated with mycophenoloic acid (MPA). The histological injury pattern associated with MPA in the large bowel is well documented in the literature, however, less extensively in the duodenum. Aims: To investigate the histological spectrum of duodenal injury specifically ...
de Heredia L L LL Department of Radiology, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Ayelsbury, - - 2014
Study design:Prospective study.Objective:To ascertain the prevalence of posterior circulation stroke in traumatic chronic spinal cord injured (SCI) patients and associated traumatic vertebral artery injuries (VAI).Methods:All adult patients with cervical SCI and American Spinal Injury Association Impairment Scale (AIS) grade A or B referred for follow-up magnetic resonance imaging of their ...
Deras Pauline P From the Trauma Intensive Care Unit and Level 1 Regional Trauma Center (P.D., J.M., X.C., J.C.), Department of Pharmacy (M.V.), Lapeyronie University Hospital; Department of Hemovigilance and Transfusion (P.L.), Lapeyronie University Hospital; Department of Biological Hematology (J.-F.S.), Saint Eloi University Hospital; and Institut National de la Santé et de la Recherche Médicale (X.C.), Equipe INSERM U1046, Montpellier, F-34295 Cedex 5, - - 2014
Early detection of a fibrinogen deficit in the initial phase of trauma is a determinant for anticipating massive blood loss. Hemostatic impairment should rationally be associated with an overall depletion of clotting factors, leading to early coagulopathy. The main objective of this study was to evaluate whether the severity of ...
Tu Yuexing Y Intensive Care Unit, Zhejiang Provincial People's Hospital , Hangzhou , China - - 2014
Abstract Background: Acute kidney injury (AKI) during sepsis is associated with poor outcome. However, diagnosis of AKI with serum creatinine (SCr) level change is neither highly sensitive nor specific. Therefore, identification of novel biomarkers for early diagnosis of AKI is desirable. Aims: To evaluate the capacity of combining urinary netrin-1 ...
Liakoni Evangelia E Department of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, - - 2014
Treatment with the new oral anticoagulant rivaroxaban can be associated with severe liver injury. We report 2 patients with predominantly hepatocellular liver injury that had onset during treatment with rivaroxaban. Both were symptomatic, had massively elevated transaminase activity levels and hyperbilirubinemia, and fulfilled the criteria of Hy's law. Liver biopsy ...
Chełstowska Beata B Department of Biochemistry - - 2014
Abstract The cerebrospinal fluid (CSF) used for identification of molecular biomarkers in amyotrophic lateral sclerosis (ALS) is mainly obtained from lumbar puncture (LP) performed to exclude other causes of motor neuron damage. Aim: The aim of the study was to analyze whether CSF of ALS patients obtained for diagnostic purposes ...
Raj Rahul R Department of Neurosurgery, Töölö Hospital, Helsinki University Hospital, Topeliuksenkatu 5, PB 266, FI-00029 HUS, Helsinki, Finland. Electronic address: - - 2014
By analysing risk-adjusted mortality ratios, weaknesses in the process of care might be identified. Traumatic brain injury (TBI) is the main cause of death in trauma, and thus it is crucial that trauma prediction models are valid for TBI patients. Accordingly, we assessed the validity of the RISC score in ...
Wu Xing X Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: - - 2014
Patients with traumatic brain injury (TBI) are more vulnerable to develop hypokalaemia, we sought to investigate the prevalence, and the relationship between severe hypokalaemia and the mortality of traumatic brain injury patients. Isolated traumatic brain patients who had hypokalaemia (serum potassium <3.5mmol/L) and age≥14yrs were recruited into the study between ...
Zangbar Bardiya B Division of Trauma, Department of Surgery, University of Arizona, Tucson, AZ, - - 2014
The aim of our study was to evaluate the clinical outcomes in patients on preinjury Ibuprofen with traumatic brain injury. We performed a 2-year analysis of all patients on prehospital Ibuprofen with traumatic brain injury and intracranial hemorrhage. Patients on preinjury Ibuprofen were matched using propensity score matching to patients ...
Lee Chien-Te CT Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2014
Background: Removal of protein-bound uremic toxins by dialysis therapy is limited. The effect of oral adsorbent AST-120 in chronic dialysis patients has rarely been investigated. Methods: AST-120 was administered 6.0 g/day for 3 months in 69 chronic dialysis patients. The blood concentrations of indoxyl sulfate, p-cresol sulfate and biomarkers of ...
Lin Hsing-Lin HL Division of Trauma, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, - - 2014
Alcohol is found to have neuroprotection in recent studies in head injuries. We investigated the association of blood alcohol concentration (BAC) with mortality of patients with blunt head injury after traffic accident. All patients sustaining blunt head injury caused by traffic accident brought to our emergency department who had obtained ...
Verma Ankur A Department of Emergency Medicine, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain, - - 2014
Hemorrhage is the second leading cause of death in trauma patients preceded only by traumatic brain injury. But hemorrhagic shock is the most common cause of preventable death within 6 hours of admission. Traumatic coagulopathy is a hypocoagulable state that occurs in the most severely injured. International normalized ratio (INR) ...
Walkey Allan J AJ The Pulmonary Center, Boston University School of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Boston Medical Center, Boston, Massachusetts, United States of - - 2014
Adiponectin (APN) is an anti-inflammatory hormone derived from adipose tissue that attenuates acute lung injury in rodents. In this study, we investigated the association between circulating APN and outcomes among patients with acute respiratory distress syndrome (ARDS). We performed a retrospective cohort study using data and plasma samples from participants ...
Zhang Wei W aDepartment of Neurology, Shengjing Hospital of China Medical University bSchool of Kinesiology, Shenyang Sport University, Shenyang, - - 2013
Inflammation plays a crucial role in the pathogenesis and prognosis of stroke. This study aims to investigate the relationship between acute ischemic stroke (AIS) and lipoprotein(a) [Lp(a)] levels and to determine the prognosis value of Lp(a) to predict the functional outcome. A total of 153 patients with AIS and 120 ...
Ma Lijuan - - 2013
We investigated serum lipoprotein(a) complexes with beta2-glycoprotein I [β2-GPI-Lp(a)] levels in ischemic stroke patients. Serum β2-GPI-Lp(a), oxidized Lp(a) [ox-Lp(a)] and Lp(a) levels were determined in 124 ischemic stroke patients and 64 normal controls. The severity and clinical outcome of ischemic stroke patients were evaluated by the National Institutes of Health ...
Melamed Michal L - - 2013
Multiple solutes are retained in uremia, but it is currently unclear which solutes are toxic. Small studies suggest that protein-bound solutes, such as p-cresol sulfate and indoxyl sulfate and intracellular solutes, such as methylamine (MMA) and dimethylamine (DMA), may be toxic. Our objective was to test whether elevated levels of ...
Shen Jenny I JI Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA, USA. - - 2013
Although heparin is used to anticoagulate the extracorporeal circuit for most patients on maintenance hemodialysis (HD), some patients undergo heparin-free HD. We describe the determinants of heparin-free HD and its association with adverse outcomes using data from a national dialysis provider merged with Medicare claims. We identified patients aged ≥67 ...
Hyun Hye Sun - - 2013
Indoxyl sulfate and p-cresyl sulfate are important protein-bound uremic retention solutes whose levels can be partially reduced by renal replacement therapy. These solutes originate from intestinal bacterial protein fermentation and are associated with cardiovascular outcomes and chronic kidney disease progression. The aims of this study were to investigate the levels ...
Anower-E-Khuda Md Ferdous - - 2013
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype, and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2 which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains. To examine if the ...
Vogt Anja - - 2013
Introduction: LDL-apheresis is a treatment option for familial hypercholesterolemia (FH) with country-specific thresholds for LDL-cholesterol (LDL-C) for initiation. Apheresis also reduces lipoprotein(a) [Lp(a)] and may be used to lower Lp(a) in high-risk patients. Mipomersen, an apolipoproteinB-synthesis-inhibitor, reduces LDL-C and Lp(a). We hypothesized that mipomersen may prevent the necessity for apheresis ...
Yeo Sang Seok SS Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu 705-717, Republic of - - 2013
Transtentorial herniation is one of the causes of motor weakness in traumatic brain injury. In this study, we report on a patient who underwent decompressive craniectomy due to traumatic intracerebral hemorrhage. Brain CT images taken after surgery showed intracerebral hemorrhage in the left fronto-temporal lobe and left transtentorial herniation. The ...
Unal Elif - - 2013
Abstract The role of atherosclerosis in ischemic stroke has been intensively investigated in recent years, and homocysteine and Lp(a) were found to have roles during the process. This study aims to investigate the relationship between acute ischemic stroke and Lp(a) and Hcy levels and to determine the prognosis and functional ...
Yoshioka Koichiro - - 2013
Background: Risk stratification is important in the management of Brugada syndrome (BrS). Late potentials (LPs) and T-wave amplitude variability (TAV) in high-resolution ambulatory electrocardiography (ECG) were retrospectively investigated. Methods and Results: One hundred and twenty-seven patients diagnosed with BrS on 12-lead ECG were classified into 3 groups: documented ventricular fibrillation (VF)/asystole (n=19), ...
Agarwal Rajiv - - 2012
Intradialytic hypotension (IDH) produces uncomfortable symptoms for the patient and reduces the efficiency of dialysis. IDH may be an important cause of vascular access thrombosis. Automatic biofeedback-controlled dialysis changes dialysate conductivity and ultrafiltration during dialysis. A number of trials suggest that automatic feedback-controlled dialysis improves IDH in part by improvement ...
Ashfaq Fauzia - - 2012
This cross-sectional study investigated the association of lipoprotein(a) [Lp(a)] levels as an atherosclerosis predictor and their relationship to the severity of coronary artery disease (CAD). 360 consecutive patients at Sanjay Gandhi Postgraduate Institute of Medical Sciences and King George's Medical University hospitals, Lucknow, North India, with chest pains, CAD symptoms ...
Masuda Masaharu - - 2012
AIMS: In patients with paroxysmal atrial fibrillation (AF), the P-wave signal-averaged electrocardiogram often demonstrates a low-amplitude potential at the terminal part of filtered P-wave (atrial late potential: A(LP)), which would originate from delayed pulmonary vein (PV) potentials. The aim of this study was to investigate the impact of PV isolation ...
de Ruijter Jessica - - 2012
INTRODUCTION: Mucopolysaccharidoses (MPSs) are a group of lysosomal storage disorders (LSDs) caused by a defect in the degradation of glycosaminoglycans (GAGs). The accumulation of GAGs in MPS patients results in extensive, severe and progressive disease. Disease modifying therapy is available for three of the MPSs and is being developed for ...
Schriever V A - - 2012
Olfactory dysfunction is a common complaint in a large number of people. As the aetiologies of olfactory dysfunction vary greatly so do the treatment approaches. The aim of this retrospective study was to evaluate treatment with systemic corticosteroids, particularly focusing on its effectiveness on the different olfactory dysfunction aetiologies. Although ...
Djukic M - - 2012
BACKGROUND: The chemical composition of the cerebrospinal fluid (CSF) is age-dependent. METHODS: Routine CSF parameters, the indications for lumbar puncture (LP), and the most frequent complications were retrospectively studied in patients older (n = 167) and younger (n = 36) than 65 years. RESULTS: In the absence of meningeal inflammation, the mean CSF lactate ...
Yagci Cemil - - 2012
PURPOSE: Percutaneous nephrostomy (PCN) in a nondilated pelvicaliceal system is technically challenging. We describe an effective method to achieve transient dilatation of the pelvicaliceal system via induction of diuresis using infusion of a diuretic agent in normal saline, therefore allowing easier access to the pelvicaliceal system. METHODS: Under real-time ultrasound ...
Demir Caner Feyzi - - 2012
BACKGROUND: We sought to determine the risk factors and clinical outcomes of pregnant women with cerebral venous thrombosis (CVT). METHODS: Nineteen pregnant patients with a diagnosis of CVT were followed in the neurology unit between 2009 and 2012. Patients with central nervous system infection and with CVT secondary to invasive ...
Fischer M Dominik - - 2012
BACKGROUND AND AIM: In a previous study, retinal nerve fiber layer thickness (RNFLT) loss was shown as part of the neurodegenerative process in multiple system atrophy (MSA). Here, we investigate in a larger cohort of MSA patients whether the RNFLT loss translates into respective visual field defects. METHODS: Spectral domain ...
Mancuso C A - - 2012
Background: Although pulmonary involvement is common in systemic lupus erythematosus (SLE), its effects on healthy lifestyle physical activity and its association with fatigue have not been well characterized. The goals of this study were to describe pulmonary function measured by office-based spirometry in patients with SLE and to compare spirometry ...
Fletcher Donald C - - 2012
PURPOSE.: To assess whether age-related macular degeneration (AMD) patients are aware of binocular central visual field defects. METHODS.: One hundred fifty-three consecutive AMD patients in their initial low-vision rehabilitation evaluation were immediately asked at the beginning of their visit (1) whether they were able to see any blind spots or ...
Meretoja Atte - - 2012
BACKGROUND AND PURPOSE: The purpose of this study was to provide a simple and practical clinical classification for the etiology of intracerebral hemorrhage (ICH). METHODS: We performed a retrospective chart review of consecutive patients with ICH treated at the Helsinki University Central Hospital, January 2005 to March 2010 (n=1013). We ...
Hardasmalani Madhu Dunichand - - 2012
OBJECTIVE: The objective of this study was to determine the yield of diagnostic workup in children presenting with complex febrile seizures. METHODS: We performed a retrospective review of charts of patients who presented to our pediatric emergency department with complex febrile seizures (focal, prolonged, or recurrent). Patients with known seizure ...
Broder Anna - - 2013
Antiphospholipid antibodies (aPL) play an active role in the pathogenesis of the antiphospholipid syndrome (APS). Primary prevention in APS may be aimed at decreasing existing elevated aPL levels, or preventing high aPL titers and/or lupus anticoagulant (LAC) from developing in the first place. Hydroxychloroquine (HCQ) has been shown in retrospective ...
Alessandri Cristiano - - 2012
Autophagy, the cytoprotection mechanism that takes place under metabolic impairment, has been implicated in the pathogenesis of autoimmunity. Here, we investigated the spontaneous and induced autophagic behavior of T lymphocytes from patients with systemic lupus erythematosus (SLE) compared with that of T lymphocytes from healthy donors by measuring the autophagy ...
Sugiyama Koichi - - 2012
BACKGROUND: This study aimed to describe the epidemiologic characteristics of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in Japan. METHODS: We used the database of the Ministry of Health, Labour and Welfare (MHLW) from 2006 to 2008, and analyzed data from 938 patients (MPA = 697, GPA = 241) who fulfilled the MHLW ...
Niepel Graham - - 2012
Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system, leading to chronic disability. Fatigue is a common and distressing symptom of MS which is unrelated to its clinical form, stage of development, the degree of disability, or the lesion load on magnetic resonance imaging. Fatigue in ...
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