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Malmqvist L L 1] Department of Spinal Cord Injuries, Glostrup hospital/Rigshospitalet 2081, Copenhagen, Denmark [2] Department of Clinical Neurophysiology, Rigshopitalet, Copenhagen, - - 2014
Objectives:Spinal cord injury (SCI) often results in severe dysfunction of the autonomic nervous system. C1-C8 SCI affects the supraspinal control to the heart, T1-T5 SCI affects the spinal sympathetic outflow to the heart, and T6-T12 SCI leaves sympathetic control to the heart intact. Heart rate variability (HRV) analysis can serve ...
Noordman Bo Jan BJ Department of Otorhinolaryngology and Head and Neck Surgery, The EMGO Institute for Health and Care Research VU University Medical Center, Amsterdam, The - - 2014
To identify factors associated with sudden drops in hearing level after minor head trauma in patients with an enlarged vestibular aqueduct (EVA). A systematic review of the literature on sudden drops in hearing level after minor head trauma in patients with an EVA was conducted. The studies were retrieved from ...
Tang Weibing W Department of Intensive Care, the 208th Hospital of PLA, 4799 Xian Road, Changchun, 130062, - - 2014
Acute respiratory distress syndrome is a life threatening respiratory condition characterized by breakdown of the alveolar-capillary barrier, leading to flooding of the alveolar space producing the classical chest radiograph of bilateral pulmonary infiltrates. In this study, we employed lung protective ventilation strategies in patients without acute lung injury (ALI) to ...
Gluhovschi Gheorghe G Division of Nephrology, Romanian Academy of Medical Sciences, Emergency County Hospital , Timisoara , Romania - - 2014
Abstract Introduction and aims: Balkan endemic nephropathy (BEN), a regional tubulointerstitial kidney disease encountered in South-Eastern Europe, with still undefined etiology and inexorable evolution towards end stage renal disease, raises the question of the relative contribution of family and environmental factors in its etiology. In order to evaluate the intervention ...
Timmermans Kim K 1Department of Intensive Care Medicine, Radboud university medical center, Nijmegen, the Netherlands 2Department of Anesthesiology, Radboud university medical center, Nijmegen, the Netherlands 3Department of Emergency Medicine, Radboud university medical center, Nijmegen, the Netherlands 4Helicopter Emergency Medical Service, Radboud university medical center, Nijmegen, The Netherlands 5Department of Surgery, Radboud university medical center, Nijmegen, the - - 2014
Both the initial trauma and the subsequent hemodynamic instability may contribute to intestinal damage, which is of great importance in (immunological) post-trauma complications. The study assesses intestinal damage using the biomarker intestinal Fatty Acid Binding Protein (iFABP) in trauma patients during the first days of their hospital admission and the ...
Atkins Christopher - - 2014
A 61-year old woman was admitted with increasing dyspnea and deranged liver function tests. A chest X-ray revealed small volume lungs with reticulo-nodular shadowing. High resolution computed tomography of the chest revealed interlobular septal thickening. The patient subsequently underwent an open lung biopsy and ultrasound-guided liver biopsy, which were consistent ...
Gatson Joshua W JW From the Department of Surgery, University of Texas Southwestern Medical Center, - - 2014
In previous studies, after injury, burn patients experienced an increase in neuro-inflammation, edema, and neuronal cell death. As demonstrated in other brain injury models, fluid-based biomarkers such as phosphorylated neurofilament-H (pNFL-H) have been shown to correlate with injury severity. In this study the authors hypothesized that burn-injured patients have an ...
Güzelküçük U U Gulhane Military Medical Academy, Department of Physical Medicine and Rehabilitation, Turkish Armed Forces Rehabilitation Center, Ankara, - - 2014
Study design:Retrospective chart review.Objectives:To document urinary tract abnormalities (UTAs) in patients with spinal cord injury (SCI) and to assess demographic and clinical features associated with UTA detected via ultrasound (US).Setting:Turkish Armed Forces Rehabilitation Center, Ankara, Turkey.Methods:The medical and radiological records of all patients with SCI were screened. Variables in each ...
Ho K M KM Department of Intensive Care Medicine, Royal Perth Hospital, Perth, Western - - 2014
Fatal pulmonary embolism is the third most common cause of death after major trauma. We hypothesised that the Trauma Embolic Scoring System (TESS) would have adequate calibration and discrimination in a group of severely injured trauma patients in predicting venous thromboembolism (VTE), and could be used to predict fatal and ...
Seo Jeong Pyo JP Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University , Taegu , Republic of - - 2014
Abstract Background: Little is known about injury of the corticospinal tract (CST) in patients with mild traumatic brain injury (TBI). This study reports on patients with mild TBI who showed traumatic axonal injury of the CST in the sub-cortical white matter, as demonstrated by diffusion tensor tractography (DTT). Methods: Four ...
Kumar Saurabh S Department of Cardiology; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, - - 2014
The transesophageal echo probe (TEE) is commonly used before and during atrial fibrillation (AF) ablation under general anesthesia (GA). We sought to determine the potential contribution of the TEE probe to esophageal injury after pulmonary vein isolation (PVI) alone for paroxysmal AF. 76 patients undergoing PVI with TEE, PVI/TEE, 16 ...
Morbitzer Kathryn A KA Division of Practice Advancement and Clinical Education, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 115 Beard Hall, Campus Box 7574, Chapel Hill, NC, 27599, - - 2014
Therapeutic strategies that cause an alteration in patient temperature, such as controlled normothermia (CN), therapeutic hypothermia (TH), and pentobarbital infusion (PI), are often used to manage complications caused by acute brain injury. The purpose of this study was to evaluate pharmacokinetic (PK) parameters of vancomycin in patients with acute brain ...
You Kicheol K Department of Emergency Medicine, Burn Center, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, 12, Beodeunaru-ro 7-gil (Youngdeungpo-dong 2-ga), Youngdeungpo-gu, Seoul 150-719, Republic of - - 2014
This study was to re-evaluate inhalation injury as a prognostic factor in burn patients and to determine the factors that should be considered when refining the definition of inhalation injury. A total of 192 burn patients (152 men, 40 women; mean age, 46.1±13.8 years) who were suspected to have an ...
Voth Maika - - 2014
Abstract Background: Trauma patients sustaining abdominal trauma exhibit high risk of organ failure and/or sepsis aggravating morbidity and mortality during the post-traumatic course. The present study re-evaluates L- and I-FABPs (small fatty acid binding proteins) as early biomarkers for abdominal injury (AI) in a large cohort of patients and analyzes ...
Cook Mackenzie R MR Trauma Research Institute of Oregon (TRIO), Division of Trauma, Critical Care and Acute Care Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: - - 2014
Trauma patients exhibit a complex coagulopathy which is not fully understood and deep venous thrombosis (DVT) rates remain high. The effects of alcohol (EtOH) consumption on coagulopathy in trauma patients have not been studied. We hypothesized that acute EtOH intoxication would produce a relative hypocoagulable state as measured by thrombelastography ...
Uhle Florian F From the Departments of Anaesthesiology and Intensive Care Medicine (F.U., D.V.D.N., S.L., T.M., S.W., M.A.W., C.L.), and Trauma Surgery (G.S., R.S.), Justus-Liebig-University, Giessen; and Department of Orthopaedic and Trauma Surgery (J.F.), Elbeklinikum, Stade, - - 2014
Life-threatening traumatic injuries lead to a complex inflammation-driven pathophysiology. Receptor of advanced glycation end product (RAGE) is a multiligand receptor of several endogenous alarmins, while cytokeratin 18 is a structural component of the filament of epithelial cells. Both proteins can be frequently found in plasma of patients with different diseases, ...
Chan Joshua L JL Department of Surgery, Division of Trauma and Critical Care, Cedars-Sinai Medical Center, Los Angeles, California, - - 2014
Patients sustaining traumatic injuries are at risk for development of rhabdomyolysis. The effect of obesity on this risk is unknown. This study attempted to characterize the role of obesity in the development of rhabdomyolysis after trauma. This was a retrospective review of all trauma patients with creatine kinase (CK) levels ...
Liou Douglas Z DZ Department of Surgery, Division of Trauma and Critical Care, Cedars-Sinai Medical Center, Los Angeles, California, - - 2014
Early trauma-induced coagulopathy (ETIC) is abnormal coagulation detected on presentation, but a clear description is lacking. We used thromboelastography (TEG) to characterize ETIC. Data were prospectively collected on high-acuity trauma activations at an urban Level I trauma center between July 2012 and May 2013. Patients with admission TEG before any ...
Baschera Dominik D Bern University Hospital, Neurosurgery , Freiburgstrasse , Bern, Switzerland, 3008 ; - - 2014
The association between helmet use during alpine skiing and incidence and severity of head injuries was analyzed. All patients admitted to a level 1 trauma center for traumatic brain injuries (TBI) sustained due to skiing accidents during the seasons 2000/01-2010/11 were eligible. Primary outcome was the association between helmet use ...
Suehiro Eiichi E M D Ph D Yamaguchi University School of Medicine, Neurosurgery, Ube, Yamaguchi, Japan ; - - 2014
A multicenter randomized controlled trial of patients with severe traumatic brain injury who received therapeutic hypothermia or fever control was performed from 2002 to 2008 in Japan (BHYPO). There was no difference in the therapeutic effect on traumatic brain injury between the two groups. The efficacy of hypothermia treatment, and ...
Parr Sharidan K SK Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, - - 2014
Biomarker studies for early detection of acute kidney injury (AKI) have been limited by nonselective testing and uncertainties in using small changes in serum creatinine as a reference standard. Here we examine the ability of urine L-type fatty acid-binding protein (L-FABP), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and kidney injury ...
Skinner D L DL Department of Critical Care, King Edward VIII Hospital, P/Bag X02 Congella 4013, Durban, KwaZulu-Natal 4083, South Africa; Perioperative Research Group, Department of Anaesthetics & Critical Care, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: - - 2014
This study describes the incidence and outcomes of blunt cardiac injury (BCI) in a single trauma intensive care unit (TICU), together with the spectrum of thoracic injuries and cardiac abnormalities seen in BCI. We performed a retrospective observational study of 169 patients with blunt thoracic trauma admitted from January 2010 ...
Claassen Jan J Division of Critical Care Neurology and Comprehensive Epilepsy Center, College of Physicians and Surgeons, Neurological Institute, Columbia University, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA, - - 2014
To determine the optimal use and indications of electroencephalography (EEG) in critical care management of acute brain injury (ABI). An electronic literature search was conducted for articles in English describing electrophysiological monitoring in ABI from January 1990 to August 2013. A total of 165 studies were included. EEG is a ...
Harkey Matthew S MS Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, Chapel Hill NC. Electronic address: - - 2014
There is an increased risk of developing knee osteoarthritis (OA) following anterior cruciate ligament (ACL) injury. Biomarkers may provide diagnostic, prognostic, or burden of disease indicators of OA before radiographic changes become apparent. Unfortunately, there has been no systematic review to clarify which biomarkers may be most informative following injury. ...
Feucht Matthias J MJ Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, Hugstetter Straße 55, 79016, Freiburg, Germany, - - 2014
To identify risk factors for posterior lateral meniscus root tears (PLRT) in patients with a tear of the anterior cruciate ligament (ACL). A database of 268 patients undergoing primary ACL reconstruction between 2011 and 2013 was used to identify all patients with isolated ACL tears and patients with an associated ...
Cotter Maura Brid MB Histopathology Department, St Vincent's University Hospital, Elm Park, Dublin - - 2014
Introduction: Diarrhoea following orthotopic liver transplantation (OLT) is a significant clinical problem associated with mycophenoloic acid (MPA). The histological injury pattern associated with MPA in the large bowel is well documented in the literature, however, less extensively in the duodenum. Aims: To investigate the histological spectrum of duodenal injury specifically ...
de Heredia L L LL Department of Radiology, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Ayelsbury, - - 2014
Study design:Prospective study.Objective:To ascertain the prevalence of posterior circulation stroke in traumatic chronic spinal cord injured (SCI) patients and associated traumatic vertebral artery injuries (VAI).Methods:All adult patients with cervical SCI and American Spinal Injury Association Impairment Scale (AIS) grade A or B referred for follow-up magnetic resonance imaging of their ...
Deras Pauline P From the Trauma Intensive Care Unit and Level 1 Regional Trauma Center (P.D., J.M., X.C., J.C.), Department of Pharmacy (M.V.), Lapeyronie University Hospital; Department of Hemovigilance and Transfusion (P.L.), Lapeyronie University Hospital; Department of Biological Hematology (J.-F.S.), Saint Eloi University Hospital; and Institut National de la Santé et de la Recherche Médicale (X.C.), Equipe INSERM U1046, Montpellier, F-34295 Cedex 5, - - 2014
Early detection of a fibrinogen deficit in the initial phase of trauma is a determinant for anticipating massive blood loss. Hemostatic impairment should rationally be associated with an overall depletion of clotting factors, leading to early coagulopathy. The main objective of this study was to evaluate whether the severity of ...
Tu Yuexing Y Intensive Care Unit, Zhejiang Provincial People's Hospital , Hangzhou , China - - 2014
Abstract Background: Acute kidney injury (AKI) during sepsis is associated with poor outcome. However, diagnosis of AKI with serum creatinine (SCr) level change is neither highly sensitive nor specific. Therefore, identification of novel biomarkers for early diagnosis of AKI is desirable. Aims: To evaluate the capacity of combining urinary netrin-1 ...
Liakoni Evangelia E Department of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, - - 2014
Treatment with the new oral anticoagulant rivaroxaban can be associated with severe liver injury. We report 2 patients with predominantly hepatocellular liver injury that had onset during treatment with rivaroxaban. Both were symptomatic, had massively elevated transaminase activity levels and hyperbilirubinemia, and fulfilled the criteria of Hy's law. Liver biopsy ...
CheĊ‚stowska Beata B Department of Biochemistry - - 2014
Abstract The cerebrospinal fluid (CSF) used for identification of molecular biomarkers in amyotrophic lateral sclerosis (ALS) is mainly obtained from lumbar puncture (LP) performed to exclude other causes of motor neuron damage. Aim: The aim of the study was to analyze whether CSF of ALS patients obtained for diagnostic purposes ...
Raj Rahul R Department of Neurosurgery, Töölö Hospital, Helsinki University Hospital, Topeliuksenkatu 5, PB 266, FI-00029 HUS, Helsinki, Finland. Electronic address: - - 2014
By analysing risk-adjusted mortality ratios, weaknesses in the process of care might be identified. Traumatic brain injury (TBI) is the main cause of death in trauma, and thus it is crucial that trauma prediction models are valid for TBI patients. Accordingly, we assessed the validity of the RISC score in ...
Wu Xing X Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: - - 2014
Patients with traumatic brain injury (TBI) are more vulnerable to develop hypokalaemia, we sought to investigate the prevalence, and the relationship between severe hypokalaemia and the mortality of traumatic brain injury patients. Isolated traumatic brain patients who had hypokalaemia (serum potassium <3.5mmol/L) and age≥14yrs were recruited into the study between ...
Zangbar Bardiya B Division of Trauma, Department of Surgery, University of Arizona, Tucson, AZ, - - 2014
The aim of our study was to evaluate the clinical outcomes in patients on preinjury Ibuprofen with traumatic brain injury. We performed a 2-year analysis of all patients on prehospital Ibuprofen with traumatic brain injury and intracranial hemorrhage. Patients on preinjury Ibuprofen were matched using propensity score matching to patients ...
Batal Ibrahim I Department of Pathology , Brigham and Women's Hospital and Harvard Medical School , Boston, MA , - - 2014
Cigarette smoking has recently been recognized as a risk factor for developing nodular glomerulosclerosis and has also been frequently encountered in patients with anti-glomerular basement membrane (anti-GBM) disease. However, the concurrent presence of both patterns of glomerular injury has not been previously reported. In this article, we describe three patients ...
Plummer J M JM Department of Surgery, Radiology, Anaesthesia and Intensive Care, The University of the West Indies, Kingston 7, Jamaica. - - 2014
To determine the impact of trans-thoracic ultrasound (TTUS) in patients with chest trauma and potential cardiac injuries and to determine the outcome of patients with cardiac injury detected on TTUS. Data were obtained from the Trauma Registry for all patients presenting alive to the University Hospital of the West Indies ...
Jagdish Krishnan K Department of Orthopaedics, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, - - 2014
A seven years retrospective study was performed in 45 consecutive vascular injuries in the extremities to investigate the pattern of injuries, managements and outcomes. Motor-vehicle accidents were the leading cause of injuries (80%), followed by industrial injuries (11.1%) and iatrogenic injuries (4.4%). Popliteal and brachial artery injuries were commonly involved ...
Lee Chien-Te CT Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2014
Background: Removal of protein-bound uremic toxins by dialysis therapy is limited. The effect of oral adsorbent AST-120 in chronic dialysis patients has rarely been investigated. Methods: AST-120 was administered 6.0 g/day for 3 months in 69 chronic dialysis patients. The blood concentrations of indoxyl sulfate, p-cresol sulfate and biomarkers of ...
Lin Hsing-Lin HL Division of Trauma, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, - - 2014
Alcohol is found to have neuroprotection in recent studies in head injuries. We investigated the association of blood alcohol concentration (BAC) with mortality of patients with blunt head injury after traffic accident. All patients sustaining blunt head injury caused by traffic accident brought to our emergency department who had obtained ...
Verma Ankur A Department of Emergency Medicine, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain, - - 2014
Hemorrhage is the second leading cause of death in trauma patients preceded only by traumatic brain injury. But hemorrhagic shock is the most common cause of preventable death within 6 hours of admission. Traumatic coagulopathy is a hypocoagulable state that occurs in the most severely injured. International normalized ratio (INR) ...
Walkey Allan J AJ The Pulmonary Center, Boston University School of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Boston Medical Center, Boston, Massachusetts, United States of - - 2014
Adiponectin (APN) is an anti-inflammatory hormone derived from adipose tissue that attenuates acute lung injury in rodents. In this study, we investigated the association between circulating APN and outcomes among patients with acute respiratory distress syndrome (ARDS). We performed a retrospective cohort study using data and plasma samples from participants ...
Zhang Wei W aDepartment of Neurology, Shengjing Hospital of China Medical University bSchool of Kinesiology, Shenyang Sport University, Shenyang, - - 2013
Inflammation plays a crucial role in the pathogenesis and prognosis of stroke. This study aims to investigate the relationship between acute ischemic stroke (AIS) and lipoprotein(a) [Lp(a)] levels and to determine the prognosis value of Lp(a) to predict the functional outcome. A total of 153 patients with AIS and 120 ...
Ma Lijuan - - 2013
We investigated serum lipoprotein(a) complexes with beta2-glycoprotein I [β2-GPI-Lp(a)] levels in ischemic stroke patients. Serum β2-GPI-Lp(a), oxidized Lp(a) [ox-Lp(a)] and Lp(a) levels were determined in 124 ischemic stroke patients and 64 normal controls. The severity and clinical outcome of ischemic stroke patients were evaluated by the National Institutes of Health ...
Melamed Michal L - - 2013
Multiple solutes are retained in uremia, but it is currently unclear which solutes are toxic. Small studies suggest that protein-bound solutes, such as p-cresol sulfate and indoxyl sulfate and intracellular solutes, such as methylamine (MMA) and dimethylamine (DMA), may be toxic. Our objective was to test whether elevated levels of ...
Shen Jenny I JI Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA, USA. - - 2013
Although heparin is used to anticoagulate the extracorporeal circuit for most patients on maintenance hemodialysis (HD), some patients undergo heparin-free HD. We describe the determinants of heparin-free HD and its association with adverse outcomes using data from a national dialysis provider merged with Medicare claims. We identified patients aged ≥67 ...
Hyun Hye Sun - - 2013
Indoxyl sulfate and p-cresyl sulfate are important protein-bound uremic retention solutes whose levels can be partially reduced by renal replacement therapy. These solutes originate from intestinal bacterial protein fermentation and are associated with cardiovascular outcomes and chronic kidney disease progression. The aims of this study were to investigate the levels ...
Anower-E-Khuda Md Ferdous - - 2013
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype, and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2 which encode ubiquitously expressed glycosyltransferases involved in the polymerization of heparan sulfate (HS) chains. To examine if the ...
Vogt Anja - - 2013
Introduction: LDL-apheresis is a treatment option for familial hypercholesterolemia (FH) with country-specific thresholds for LDL-cholesterol (LDL-C) for initiation. Apheresis also reduces lipoprotein(a) [Lp(a)] and may be used to lower Lp(a) in high-risk patients. Mipomersen, an apolipoproteinB-synthesis-inhibitor, reduces LDL-C and Lp(a). We hypothesized that mipomersen may prevent the necessity for apheresis ...
Yeo Sang Seok SS Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu 705-717, Republic of - - 2013
Transtentorial herniation is one of the causes of motor weakness in traumatic brain injury. In this study, we report on a patient who underwent decompressive craniectomy due to traumatic intracerebral hemorrhage. Brain CT images taken after surgery showed intracerebral hemorrhage in the left fronto-temporal lobe and left transtentorial herniation. The ...
Unal Elif - - 2013
Abstract The role of atherosclerosis in ischemic stroke has been intensively investigated in recent years, and homocysteine and Lp(a) were found to have roles during the process. This study aims to investigate the relationship between acute ischemic stroke and Lp(a) and Hcy levels and to determine the prognosis and functional ...
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