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Goldman Morris B MB Northwestern University, Department of Psychiatry, 446 East Ontario, Suite 7-100, Chicago, IL 60611, United States. - - 2011
Polydipsic hyponatremic schizophrenic (PHS) patients exhibit altered neuroendocrine activity that has been linked to their life-threatening water imbalance, as well as to impaired function and reduced volume of the anterior hippocampus. Polydipsic patients without hyponatremia (polydipsic normonatremic schizophrenics: PNS) exhibit similar, albeit less marked, changes in neuroendocrine activity and anterior ...
Biffi Mauro - - 2010
PURPOSE OF REVIEW: Phrenic stimulation may hinder left-ventricular (LV) stimulation and prevent cardiac resynchronization therapy (CRT) delivery. We reviewed the literature to address its prevalence and clinical implications in CRT patients. RECENT FINDINGS: Phrenic stimulation prevalence ranges from 20 to 33% of patients when a posterolateral LV lead placement is ...
Rapezzi Claudio - - 2011
We previously reported in a small series of patients that (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) scintigraphy tested positive in transthyretin-related (TTR) (both mutant and wild-type) but not in primary (AL) amyloidotic cardiomyopathy (AC). We extended our study to a larger cohort of patients with AC. We evaluated (1) 45 patients with TTR-related ...
Ren Liankun - - 2011
Using intracranial electroencephalographic recordings, we identified a distinct brain activity in 3 patients with refractory epilepsy characterized by very early occurrence from 8 minutes 10 seconds to 22 minutes 40 seconds prior to clinical seizure onset, periodical appearance of slow negative baseline shift, long interpeak interval of 40 to 120 ...
Apiwattanakul Metha - - 2010
We report 12 aquaporin-4 antibody-positive patients (12% of seropositive Mayo Clinic patients identified since 2005) whose initial presenting symptom of neuromyelitis optica was intractable vomiting. The initial evaluation in 75% was gastroenterologic. Vomiting lasted a median of 4 weeks (range, 2 days-80 weeks). Optic neuritis or transverse myelitis developed after ...
Wang Xiang-Qing - - 2010
Background: Diffusion tensor imaging (DTI) is a sensitive technique for studying cerebral white matter. Only a few studies have examined the association between changes in extratemporal integrity and cognition in temporal lobe epilepsy (TLE), especially in Chinese patients. Aim: We used DTI to characterize microstructural changes and investigate their associations ...
McAuley J - - 2010
Gait disturbance is an almost universal complaint suffered by PD patients as they inevitably progress to the more severe stages of the disease. This can be partially corrected by external cues guiding placement of each step. "Walking glasses", spectacles that present the patient with visual cues to aid walking without ...
Mansour Ahmad M - - 2010
To record retinal vascular events following intravitreal bevacizumab injection. Collaborative multi-centre retrospective case series. Eight patients were documented to have central retinal artery occlusion (four patients), branch retinal artery occlusion, capillary occlusion, central retinal vein occlusion and branch retinal vein occlusion (one patient each) within 0-55 days (median 2 weeks) ...
Gallagher Anne A Carol and James Herscot Center for Tuberous Sclerosis Complex, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, - - 2010
Tubers are the most common brain lesions in tuberous sclerosis complex (TSC), and typically remain stable in size and appearance. We present the case of a young male with global developmental impairment and autistic features as well as multiple and mixed daily seizures. The patient had a prominent right frontal ...
Genead M A MA Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612-7234, - - 2011
To determine the prevalence of cystic macular oedema (CME) in patients with choroideremia (CHM) by using spectral-domain optical coherence tomography (SD-OCT). A total 16 patients affected with CHM were enrolled in the study. All patients underwent a complete eye examination. SD-OCT was performed using an OPKO spectral-domain OCT/SLO instrument. The ...
Lin Pei-Wen - - 2011
To compare parameters for retinal nerve fiber layer (RNFL) thickness, optic nerve head (ONH) measurements, and macular thickness in patients with different severities of obstructive sleep apnea/hypopnea syndrome (OSAHS) versus normal controls. Patients presenting with snoring and daytime sleepiness who underwent overnight polysomnography to determine OSAHS severity were recruited, and ...
Xiaoyun M A - - 2010
To assess chloroquine (CQ) toxicity by visual field testing, multifocal electroretinography (mfERG) and measurement of retinal nerve fibre layer (RNFL) thickness in patients with rheumatoid arthritis (RA) under treatment with CQ but with normal ocular fundus manifestation. 60 RA patients taking CQ, 30 RA patients not receiving CQ treatment and ...
Sen Parveen - - 2010
To evaluate focal retinal function in patients presenting with features of X-linked retinoschisis (XLRS), with the use of multifocal electroretinography (mfERG). Consecutive observational case-control study. Eighteen eyes of 9 patients who presented to the retina clinic of Sankara Nethralaya from 2005 to 2008. XLRS was diagnosed clinically and corroborated with ...
Stahl Andreas A University Eye Hospital Freiburg, Freiburg, Germany. - - 2010
This study compares vitreal levels of erythropoietin (EPO) in patients with retinal vein occlusion (RVO) with control subjects. In addition, it investigates different RVO disease parameters (time of vein occlusion, patient age, vitreal vascular endothelial growth factor (VEGF) levels, and extent of central macular edema) for possible correlations with vitreal ...
Jaiswal Sushila - - 2011
Central neurocytomas are low-grade tumors of neuronal origin located in the lateral ventricle that present predominantly with raised intracranial pressure. In this retrospective study, we investigated the clinical, radiological, histopathological and immunohistochemical features of eight patients (seven males and one female; age range 16-61 years; mean=35.1 years) with neurocytoma. Raised ...
Sorri Iiris - - 2010
A gabaergic antiepileptic drug, vigabatrin (VGB), is known to induce bilateral concentric visual field defects (VFD) in 30-40% of treated patients. Although the clinical and electrophysiological features of VFDs are well documented, the mechanism of retinal toxicity is still unclear. To determine if low basal ornithine-δ-aminotranspherase (OAT) activity is implicated ...
Riera-Mestre A - - 2010
To describe the clinical characteristics and evolution of a series of adult patients hospitalized for neuro-Behçet disease (NBD). Consecutive patients admitted for NBD in a teaching hospital were retrospectively selected. Disability at discharge and during follow-up was graded with the modified Rankin Scale, and outcome classified as good or poor ...
Baker Michelle L - - 2010
BACKGROUND AND PURPOSE: The relationship of cortical and subcortical cerebral atrophy to cerebral microvascular disease is unclear. We aimed to assess the associations of retinal vascular signs with cortical and subcortical atrophy in patients with acute stroke. METHODS: In the Multi-Centre Retinal Stroke Study, 1360 patients with acute stroke admitted ...
Noma Hidetaka - - 2010
This study aimed to investigate whether vascular endothelial growth factor (VEGF) or interleukin-6 (IL-6) influence macular oedema in patients with central retinal vein occlusion (CRVO). Sixteen consecutive patients with unilateral CRVO and macular oedema were studied, along with eight age- and sex-matched patients without ischaemic ocular disease. Retinal ischaemia was ...
Ikeda Yasuhiro - - 2010
BACKGROUND: Asteroid hyalosis (AH) is a condition in which cream-colored or white spherical particles are suspended in the vitreous body. Asteroid hyalosis is considered not to cause decreased vision or any other visual symptoms except in rare cases. There have been a few reports of AH in patients with retinitis ...
Noma Hidetaka - - 2010
We investigated whether pigment epithelium-derived factor (PEDF) or vascular endothelial growth factor (VEGF) influence macular edema in patients with branch retinal vein occlusion (BRVO). This investigation aimed to clarify the influence of PEDF in the vitreous fluid on retinal vascular permeability in patients with macular edema secondary to BRVO. The ...
Bruce Beau B BB Department of Ophthalmology and Neurology, Emory University School of Medicine, 1365-B Clifton Road, NE, Atlanta, GA 30322, USA. - - 2010
Neurologists frequently evaluate patients complaining of vision loss, especially when the patient has been examined by an ophthalmologist who has found no ocular disease. A significant proportion of patients presenting to the neurologist with visual complaints have nonorganic or functional visual loss. Although there are examination techniques that can aid ...
Laemmer Robert - - 2010
Since papilledema in idiopathic intracranial hypertension is a passive event not primarily affecting the visual tract, resolution with restitution ad integrum is expected if intracranial pressure is rebalanced. Retinal nerve fiber swelling due to papilledema in the acute phase and possible axon loss after long-lasting elevated intracranial pressure was investigated ...
Martinez Michael R - - 2011
The authors examined the peripapillary (3.4-mm diameter) retinal nerve fiber layer thickness (RNFL thickness) as depicted by optical coherence tomography (OCT) in young patients with pseudopapilledema or papilledema. In 17 consecutive patients (6 to 20 years old) with bilateral newly diagnosed papilledema or pseudopapilledema, the eye with the thicker mean ...
Guigui Benjamin - - 2011
Aims Drusen are rarely observed in patients <50&emsp14;years of age. Two types of early onset drusen (EOD) are commonly described: basal laminar drusen (BLD) and drusen associated with Malattia Leventinese (ML). Our purpose was to classify the phenotype of EOD on the basis of fundus examination, and fluorescein angiography (FA) ...
Kuhn C - - 2010
Patients with postchiasmatic visual field defects often show a contralesional bias towards the scotoma in line bisection or when indicating their visual subjective straight ahead (VSSA). Recent evidence suggests a retinotopic misrepresentation of visual space in patients with homonymous quadrantanopia (HQ). We therefore assessed in the present study whether patients ...
Akçakaya Aylin Ardagil - - 2010
Detecting retinal vigabatrin toxicity in patients with partial symptomatic or cryptogenic epilepsy can be challenging because of preexisting visual field defects secondary to a structural abnormality in the brain or lack of collaboration. The aim of this study was to measure the retinal nerve fiber layer thickness (RNFLT) with optic ...
Lambert Stéphanie - - 2010
The test is simple and sensitive enough to separate normal subjects from patients suffering from a vestibular loss. There was also a good correlation between the objective results and the subjective complaint of oscillopsia. Oscillopsia (i.e. blurred vision while walking) is often reported by patients suffering from vestibular loss. We ...
Shields Carol L - - 2010
OBJECTIVE: To evaluate choroidal halo nevus. METHODS: We performed a retrospective medical record review on all patients with a clinical diagnosis of choroidal halo nevus treated at the Ocular Oncology Service at Wills Eye Institute from April 1, 1974, through June 30, 2008. Their clinical characteristics and natural history were ...
Lau Ling-Ing - - 2010
Oxidative stress has been implicated as a major contributor to age-related macular degeneration (AMD). 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is one of the most abundant oxidative products of DNA damage and represents a noninvasive and sensitive biomarker of oxidative stress. The authors investigated the 8-OHdG levels in aqueous humor of patients with exudative ...
Madge Simon N - - 2010
PURPOSE: To describe a case series of patients with anterior orbital invasion by medial canthal basal cell carcinoma (BCC) managed with non-exenterating surgery. DESIGN: International, multicenter, retrospective, noncomparative, consecutive case series. PARTICIPANTS: Twenty patients identified from the individual institutions' databases with histologically confirmed orbital invasion by periocular BCC. METHODS: Examination ...
Kerr Nathan M - - 2010
OBJECTIVES: To determine the prevalence and spectrum of retinal changes in juvenile Paget disease. METHODS: Observational case series and literature review with analysis. Patients with clinical and molecular evidence of juvenile Paget disease were recruited by members of the International Hyperphosphatasia Collaborative Group. Participants underwent ophthalmic examinations consisting of at ...
Rasier Rifat - - 2010
PURPOSE: To determine intravitreal levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) in patients with rhegmatogenous retinal detachment (RD). METHODS: Vitreous samples were collected from 22 eyes of 22 patients during vitrectomy procedures for RD. For controls, vitreous samples were obtained from 12 eyes ...
Landeiro José Alberto - - 2010
We report our experience on the treatment of tuberculum sellae meningiomas (TSMs) regarding the involvement of the optic canal and clinical outcomes. We reviewed 23 patients who were operated on between January 1997 and December 2008. The surgical approach was unilateral subfrontal supraorbital osteotomy in one piece. Attempts were made ...
Genead Mohamed A - - 2010
Fundus albipunctatus is a form of congenital stationary night blindness characterized by an early onset and nonprogressive impairment of night vision and the presence of numerous dull-white punctate lesions scattered throughout the fundus, while retinitis punctata albescens patients often show similar fundus changes but manifest a severe and progressive hereditary ...
Johnson Davin - - 2010
To determine the incidence and characteristics of acute intraocular inflammation after intravitreal bevacizumab injections from a tertiary care retinal practice. Retrospective cohort study. A consecutive series of patients who had received bevacizumab injections performed by a single surgeon. We reviewed the records of all patients with severe anterior chamber inflammation ...
Bawazeer Ahmed - - 2010
To describe the clinical outcome of refractory ocular Behçet disease with adalimumab therapy. Retrospective review of records. Twenty-one eyes of 11 male patients with ocular Behçet disease received adalimumab therapy. Of the 21 eyes, 17 had improvement of visual acuity by more than 3 lines after the average follow-up of ...
Bruce B B - - 2010
Idiopathic intracranial hypertension (IIH) typically affects young, obese women. We examined 2 groups of atypical patients with IIH: those with a normal body mass index (BMI) and those at least 50 years of age. A retrospective cohort study of 407 consecutive adult patients with IIH with known BMI from 3 ...
Segal Laura - - 2010
BACKGROUND: Children born with neurofibromatosis type 1 (NF1) have an increased risk of developing optic pathway gliomas (OPGs) during childhood. The aim of this study is to evaluate the clinical course of NF1 patients with OPGs at our institution with respect to visual and endocrinologic morbidity. METHODS: Retrospective case series ...
Sisk Robert A - - 2010
PURPOSE: The purpose of this study was to describe a subset of severely affected patients with neurofibromatosis type 2 (NF2), multiple central nervous system tumors, and characteristic retinal lesions. METHODS: This is a retrospective observational case series of 4 patients with NF2. The time domain-optical coherence tomography findings of three ...
Jumper J Michael - - 2010
The purpose of this study was to describe the angiographic features and visual impact of macular fibrosis in patients with Coats disease. This is a single institution retrospective case series. Charts of patients diagnosed with Coats disease between 1973 and 2007 were reviewed. Data collected included patient demographics, treatment method, ...
Lee Dong-Hoon - - 2010
Impending central retinal vein occlusion is associated with mild or no loss of vision; however, its progress and vision prognosis have not been clearly defined until now. Therefore, we studied the progress and prognoses in patients with impending central retinal vein occlusion. For this study, we selected ten subjects who ...
Fahnehjelm Kristina Teär - - 2012
The aims of the present study were to investigate visual function, ocular motility and ocular characteristics in children and young adults with complex I deficiency. In a prospective study with longitudinal follow-up, the visual and ocular outcome in 13 patients with deficiency in complex I [nicotine-amide adenine dinucleotide (NADH) dehydrogenase] ...
Negrao Silvana - - 2010
This article describes the optical coherence tomography (OCT) findings in 4 patients with degenerative retinoschisis and symptomatic retinal detachment. All patients underwent pars plana vitrectomy, fluid gas exchange, and endolaser treatment. The OCT appearance of retinoschisis and visual outcomes were variable. OCT appears to be useful in understanding the anatomy ...
Campochiaro Peter A PA Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, USA. - - 2010
Stimulation of nicotinic acetylcholine (nACh) receptors on vascular endothelial cells promotes angiogenesis and vascular permeability in animal models. The safety and bioactivity of topical mecamylamine, an antagonist of nACh receptors, was tested in patients with diabetic macular edema. A multicenter phase I/II clinical trial. Twenty-three patients with chronic diabetic macular ...
Huang Jingjing - - 2010
BACKGROUND: The optical coherence tomography (OCT) and clinical characteristics of traumatic macular holes (TMHs) can be compared to those of idiopathic macular holes (IMHs) to gain insights into the pathogenesis of both. METHODS: The demographic data and visual acuity of 73 consecutive patients with unilateral, full-thickness TMHs and 182 consecutive ...
Ho Joseph J New England Eye Center, Tufts Medical Center, Boston, Massachusetts, - - 2010
PURPOSE. To investigate the characteristics of a spectral-domain optical coherence tomography (SD-OCT) image phenomenon known as the mirror artifact, calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). METHODS. OCT macular cube 512 x 128 scans taken between January ...
Jayasundera Thiran - - 2010
PURPOSE: To investigate the prevalence of a peripapillary dark choroid ring on fluorescein angiography (FA) and the associated clinical features in patients with Stargardt disease. DESIGN: Retrospective review of 135 patients with Stargardt disease. METHODS: The presence or absence of a peripapillary dark choroid ring on FA was noted and ...
Fonollosa A - - 2010
To investigate whether interleukine-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are related with macular oedema in patients with branch retinal vein occlusions (BRVOs). Retrospective case-control study. Nineteen patients who had macular oedema due to BRVO and nine patients with non-ischaemic ocular diseases (control group). Macular oedema was examined by optical ...
Rencová Eva - - 2011
Purpose:  To evaluate the influence of haemorheopheresis on anatomical and functional findings in patients with soft-drusen maculopathy. Methods:  We investigated 29 eyes (16 patients) and randomized 25 eyes (16 controls) with soft-drusen maculopathy [soft, confluent and reticular drusen, drusenoid retinal pigment epithelium detachment (RPED)]. Each patient received a series of ...
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