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Auyeung M - - 2011
Since the first description of transient global amnesia (TGA) in 1964, its etiology has remained obscure. Reversible diffusion weighted imaging (DWI) hyperintensities in the hippocampus have been found on MRI of some patients with TGA during acute events. The implication of this is not well understood. We identified 47 patients ...
Feng Zhan-hui ZH Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, - - 2011
This study aims to investigate μ-calpain expression profiles in the anterior temporal neocortex in patients with intractable epilepsy, and to determine whether its pattern of expression is related to pathological changes seen in these patients. The study subjects consisted of 30 patients with intractable epilepsy and a control group of ...
Hays Ryan S - - 2011
Ictal automatisms of fear or sadness, of which the patient is unaware and which are not preceded by a corresponding emotion, have not been well characterized. Of 557 patients admitted for video/EEG monitoring, 2 (0.36%) were identified who had automatisms of fear and sadness. One patient was found to have ...
Wang Xiang-Qing - - 2011
We used diffusion tensor imaging to characterize microstructural changes and their associations with cognition in Chinese patients with frontal lobe epilepsy (FLE). We examined 18 adult patients with FLE and 20 healthy controls. Compared with normal controls, patients with FLE had increased mean diffusivity (MD) in the right frontal lobe ...
Choi Eun Mi - - 2011
BACKGROUND: Propofol dose requirement for loss of consciousness (LOC) in epilepsy patients would be probably affected by increasing factors [development of tolerance, up-regulated γ-aminobutyric acid (GABAA) receptors, or antiepileptic activity of propofol] and reducing factors [synergistic interaction between propofol and antiepileptic drugs (AEDs) or reduced neuronal mass in cortex] in ...
Lavinsky Daniel - - 2011
Acta Ophthalmol. 2011: 89: e89-e94 ABSTRACT.: Purpose:  To report fundus autofluorescence and optical coherence tomography (OCT) findings in patients with blunt ocular trauma. Methods:  Six eyes of six consecutive patients with blunt ocular trauma were evaluated in an observational case series using colour fundus photography, the Heidelberg Retina Angiograph 2 ...
Törnquist Alba Lucia - - 2011
This study aimed to describe the Rarebit (RB) visual field and optic nerve size/morphology in patients treated with allogeneic stem-cell transplantation (SCT) in childhood, and to determine the impact of ocular status and conditioning regimens such as total body irradiation (TBI), chemotherapy and/or immunosuppressive drugs on the RB visual field. ...
Varella Pedro Paulo Vasconcellos - - 2011
We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues ...
Velasco Tonicarlo R - - 2011
: The development of newer diagnostic technologies has reduced the need for invasive electroencephalographic (EEG) studies in identifying the epileptogenic zone, especially in adult patients with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). : To evaluate ictal single photon emission computed tomography (SPECT) in the evaluation and treatment of ...
Ragona Francesca - - 2011
Purpose:  To clarify the role of epilepsy and genetic background in determining the cognitive outcome of patients with Dravet syndrome. Methods:  In this retrospective study, we reviewed the clinical history and cognitive development of 26 patients who had been followed with standardized evaluations since seizure onset. The cognitive outcome was ...
Horacio Caraballo Roberto - - 2011
Purpose:  Early onset absence seizures have been considered a rare heterogeneous group with a poor prognosis. Only few patients may be categorized into well-known syndromes. We have evaluated electroclinical features, evolution, and the nosologic boundaries of early onset absence seizures. Methods:  Forty-six neurologically normal patients with absence seizures associated with ...
Halawa Imad - - 2011
This retrospective cross-sectional study was carried out to study the association between different levels of hyponatremia and the occurrence of epileptic seizures in patients without a prior epilepsy diagnosis. We identified from the hospital database, 363 inpatients of a Swedish County hospital who between March 2003 and August 2006 were ...
Han Myung Woul - - 2011
In temporal lobe epilepsy (TLE) there may be functional abnormalities or structural lesions that can manifest as a central auditory processing disorder, which is defined as a disorder in the recognition, discrimination, ordering, grouping, and localization of sounds, with emphasis on the processing of nonspeech sounds. We performed frequency pattern, ...
Sherman Jonathan H - - 2011
Object Seizures occur in approximately 80% of patients with low-grade gliomas (LGGs). The majority of patients are treated with anticonvulsant monotherapy; however, many patients require multidrug therapy, or their seizures are refractory to antiepileptic drugs altogether. The oral alkylating agent temozolomide has emerged as a potential initial treatment option for ...
Losey T E - - 2011
Many patients with hypothalamic hamartomas present in infancy with gelastic seizures of subcortical origin, but later develop additional seizure types, including complex partial, tonic, and generalized tonic-clonic seizures. The basic cellular mechanisms responsible for this evolution in seizure types are unknown. Using voxel-based morphometry of T1 weighted MRI scans we ...
Bae Eun-Kee - - 2011
Both ictal asystole and eating reflex seizures are rare conditions that are closely related to temporal lobe epilepsy (TLE). Patients exhibiting these two conditions simultaneously have not been previously reported. We describe two unusual cases in which patients with left TLE were confirmed to have ictal asystole and eating epilepsy ...
Verrotti Alberto - - 2011
OBJECTIVE: The goal of this study was to define the long-term outcome of absence epilepsy presenting before the age of 3years. METHODS: We retrospectively studied the medical records of 40 children from eight neuropediatric centers in Italy with respect to the personal and family histories of epilepsy or febrile seizures, ...
Clancy Robert R - - 2011
Conventional EEG (CEEG) in neonates is considered the gold standard for evaluating EEG background and detecting electrographic seizures. However, CEEG is expensive and cumbersome for long-term monitoring. A simplified method, amplitude-integrated EEG (AEEG) has been rapidly adopted to accomplish the same goals. The purpose of this study was to measure ...
Wille Christian - - 2011
Purpose:  To assess the efficacy and tolerability of chronic high-frequency deep brain stimulation (DBS) in adult patients with progressive myoclonic epilepsy (PME) syndromes. Methods:  Five adult patients (four male, 28-39 years) with PME underwent chronic high-frequency DBS according to a study protocol that had been approved by the local ethics committee. ...
Kramer Uri - - 2011
The unpredictable and random occurrence of seizures is of the most distressful issue affecting patients and their families. Unattended seizures can have serious consequences including injury or death. The objective of this study is to develop a small, portable, wearable device capable of detecting seizures and alerting patients and families ...
Brown J William L - - 2011
Forty-four patients presenting with first-ever seizure within 24 h of illicit use of amphetamine or related analogs (amphetamine-associated seizures, AAS) were identified over 8 years. Patients with AAS were compared to control groups of other first-ever seizure patients (provoked n = 126 and unprovoked n = 401). Cumulative probability of ...
Tao James X - - 2011
Purpose:  Several studies have suggested that interictal regional delta slowing (IRDS) carries a lateralizing and localizing value similar to interictal spikes and is associated with favorable surgical outcomes in patients with temporal lobe epilepsy (TLE). However, whether IRDS reflects structural dysfunction or underlying epileptic activity remains controversial. The objective of ...
Hu Wen-han WH Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, - - 2011
Gelastic seizure is an uncommon type of seizure which is characterized by recurrent bouts of unprovoked and stereotyped laughter. It is commonly observed in patients with hypothalamic hamartoma, while its association with other cerebral lesions is rare. The patient was a 15-year-old right-handed male. His chief complaints were recurrent onsets ...
Kaczorowska Magdalena - - 2011
Purpose:  The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome. Methods:  A single-center, retrospective analysis was performed of patients with documented TSC seen from 1988 to 2010 at the Children's ...
Maa Edward H - - 2011
Abstract Maa, Edward H. How do you approach seizures in the high altitude traveler. High Alt. Med. Biol. 12:13-19, 2011.-Counseling patients who suffer first-time or break- through seizures can be difficult, particularly when controllable external factors may be contributing to the lowering of their seizure threshold. High altitude as a ...
Pinto Kylvia G F D - - 2011
The incidence of sudden unexpected death in epilepsy (SUDEP) has been estimated from 0.5-1.4/1,000 person-years in people with treated epilepsy, and 9/1,000 person-years in candidates for epilepsy surgery. Potential risk factors for SUDEP include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure type and winter temperatures. The ...
Moschos Marilita M - - 2011
Purpose. To investigate the anatomic and electrophysiologic changes of the macula and the optic nerve in patients with Parkinson disease (PD) without visual impairment. Methods. Thirty-two eyes of 16 patients with PD (group A) without visual impairment were tested. Visual acuity was 20/20 or better and visual fields as well ...
Schijns Olaf E M G - - 2011
: Temporal lobe gray-white matter abnormalities (GWMA) are frequent morphological aberrances observed on MRI in patients with temporal lobe epilepsy (TLE) in addition to hippocampal sclerosis (HS). : To study the influence of temporal pole GWMA on clinical characteristics and seizure outcome in patients with HS operated on for TLE. ...
Morioka Takato - - 2011
Nonconvulsive status epilepticus (NCSE) is generally defined as a change in behavior and/or mental process from the baseline, which is associated with ongoing seizure activity or continuous epileptiform discharges on electroencephalography (EEG) in the absence of convulsive seizures. The present study investigated NCSE incidence using serial EEG during the perioperative ...
Lee Haneul - - 2011
To investigate the clinical characteristics of late-onset epilepsy combined with autism spectrum disorder (ASD), and the relationship between certain types of electroencephalography (EEG) abnormalities in ASD and associated neuropsychological problems. Thirty patients diagnosed with ASD in early childhood and later developed clinical seizures were reviewed retrospectively. First, the clinical characteristics, ...
Hood Donald C - - 2011
To describe the structural changes in the transition zone from relatively healthy retinal regions to severely affected regions in patients with retinitis pigmentosa (RP) using frequency domain optical coherence tomography (fdOCT). FdOCT line scans of the horizontal meridian were obtained from one eye of 13 patients with RP and 30 ...
Desai Jay J Department of Pediatric Neurology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA. - - 2011
To study adding an anticonvulsant in children with uncontrolled epilepsy on ≥ 1 appropriate anticonvulsants. Chart review, patients with intractable epilepsy in a neurology clinic July 1, 2004 to December 31, 2007. Inclusion: Children on ≥ 1 stable anticonvulsant who had a second, third, or fourth anticonvulsant added. Noncompliance, subtherapeutic ...
Lanz M M Epilepsy Centre, University Hospital Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany. - - 2011
Ictal-related cardiac asystole is supposed to be a risk factor for sudden unexpected death in epilepsy (SUDEP). We retrospectively analyzed the occurrence of ictal asystole in 2003 epilepsy patients undergoing long-term video EEG/ECG monitoring from 1/1999 to 6/2010 at the Freiburg epilepsy centre. Seven patients had cardiac arrest with a ...
Staley Brigid A - - 2011
To describe presenting symptoms and signs according to age group in a cohort of 243 patients with tuberous sclerosis complex (TSC) and identify earlier symptoms and signs that did not lead to immediate diagnosis. We performed a retrospective chart review for 278 patients with TSC who were examined at Children's ...
Ellmore Timothy M TM The Vivian L Smith Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, TX 77030, United States. - - 2011
Mesial temporal lobe epilepsy (MTLE) is hypothesized to involve derangement of long-range limbic connectivity, but in vivo evidence is lacking. We used diffusion tractography to investigate the relationship between hippocampal atrophy and connectivity in MTLE patients with hippocampal sclerosis (HS). Atrophy was correlated with relatively decreased connectivity density but increased ...
Wang Zhengge - - 2011
Recent functional magnetic resonance imaging (fMRI) studies have demonstrated that the resting state networks (RSNs) are impaired in various neuropsychiatric disorders. However, little is known about the changes in the functional architecture of the RSNs in idiopathic generalized epilepsy patients with generalized tonic-clonic seizures (GTCS). Resting state fMRI data were ...
Heuser Kjell K Department of Neurology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, N-0027 Oslo, Norway. - - 2011
Pharmacoresistance continues to be a major challenge in Temporal Lobe Epilepsies (TLE). A key to overcome pharmacoresistance is to identify subgroups among the TLE and disclose their specific molecular pathways. This will facilitate a tailored pharmacological treatment and improve outcome. There is growing evidence in favor of the theory that ...
Caraballo Roberto Horacio RH Hospital Nacional de Pediatría Prof. Dr. Juan P Garrahan, Buenos Aires, Argentina. - - 2011
In this study, we present the electroclinical features and evolution of patients with epileptic spasms (ES) in clusters without hypsarrhythmia and with or without focal or generalized paroxysmal discharges on the interictal EEG. We also discuss how to nosologically define these cases. Between February 1, 1990, and December, 2009, sixteen ...
Abd-El-Barr Muhammad M - - 2011
Rasmussen's encephalitis is characterized by seizures, progressive neurological deterioration and chronic inflammation of the brain. It typically presents in childhood and requires anatomic or functional hemispherectomy for seizure control. Here, we report an adult woman who presented with new onset, medically refractory seizures that were not progressive. The patient underwent ...
Yahalom G G Department of Neurology, Sheba Medical Center, - - 2011
To compare subclinical balance dysfunction in patients with various epilepsy syndromes with apparently healthy subjects. Twenty-seven patients with localization-related epilepsy (LRE), 19 with primary generalized epilepsy (PGE), who had no subjective complaints of impaired balance and no abnormal neurologic findings on examination, and 22 apparently healthy subjects, underwent static posturography ...
Mecarelli O - - 2011
The rate of early post-stroke epileptic seizures ranges from 2 to 33%. This wide range is likely due to differences in study design, patient selection and type of neurophysiological monitoring. Electroencephalography (EEG), which is not used in the routine work-up of acute stroke, is the best neurodiagnostic technique for detecting ...
Hur Yun Jung - - 2010
PURPOSE: Corpus callosotomy (CC) is a palliative surgical procedure to control atonic, tonic, or generalized tonic-clonic seizure in Lennox-Gastaut syndrome (LGS). Here, we report patients with LGS who underwent resective surgery, following CC better delineating the presumed seizure foci localized in one hemisphere. METHODS: We retrospectively reviewed seven patients with ...
Sharma Pawan - - 2011
Solitary cysticercus granuloma - a benign form of parenchymal neurocysticercosis - is considered as the most common cause of partial seizures. This study comparatively evaluated the seizure-related prognosis in patients with new-onset seizure having solitary cysticercus granuloma and in patients with normal neuroimaging. We also assessed the factors of seizure ...
Uljon Sacha N - - 2010
BACKGROUND: Serum free light chains (SFLC) are used to manage patients with light chain or hyposecretory myeloma, and may also be useful in patients with intact immunoglobulin myeloma (IIMM), because their shorter half-life may enable earlier indication of relapse/response than electrophoretic M-spikes or heavy chain (IgGA) immunonephelometry. METHODS: One thousand ...
Schneider Felix - - 2010
BACKGROUND: Propofol's potential to trigger generalized tonic-clonic seizures and epileptic discharges is still controversial. The aim of this study was to investigate the incidence of epileptic discharges and epileptic seizures in epilepsy patients anesthetized with propofol. METHODS: Thirty three patients with intractable partial epilepsy selected for video electrocorticography-monitoring were studied. ...
Almeida Andrea Garcia de - - 2010
The aim of this study was to verify incidence and characteristics of sudden unexpected death in patients (SUDEP) with refractory epilepsy and its relation to previous surgery and lesion localization. A cross sectional study was carried out in a cohort of 550 patients with refractory epilepsy followed up by the ...
de Leeuw Nicole - - 2010
We describe three patients with a comparable deletion encompassing SLC25A43, SLC25A5, CXorf56, UBE2A, NKRF, and two non-coding RNA genes, U1 and LOC100303728. Moderate to severe intellectual disability (ID), psychomotor retardation, severely impaired/absent speech, seizures, and urogenital anomalies were present in all three patients. Facial dysmorphisms include ocular hypertelorism, synophrys, and ...
Pineles Stacy L - - 2010
To report the postoperative binocular function of patients with Boston type I keratoprostheses implantation for unilateral visual impairment. Seventeen patients who underwent implantation of a Boston type I keratoprosthesis and had a best-corrected visual acuity better than 20/50 in the contralateral eye before surgery were evaluated. All subjects prospectively underwent ...
Michaelides Michel - - 2010
To describe a series of patients who have sustained a retinal vein occlusion (RVO) and also have primary angle-closure (PAC). We retrospectively ascertained demographic characteristics (age, sex, and ethnicity), presentation (history and examination findings), investigations undertaken, features of angle-closure or occludable angles (symptoms, method of diagnosis, and treatment), and outcome ...
Noe Katherine H - - 2011
Seizures can cause airway compromise and aspiration. This is a potential concern during inpatient video-EEG monitoring (vEEG), where seizures are provoked for diagnostic purposes. The frequency of aspiration and efficacy of nursing interventions to protect the airway were evaluated in this retrospective study of 590 partial complex (PC) and generalized ...
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