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Pourgheysari Batoul B aCellular and Molecular Research Center bPathology and Hematology Department cFaculty of Health, Shahrekord University of Medical Sciences, Shahrekord, - - 2014
Polymorphisms of coagulation factor XIII, an A2B2 tetramer, have been reported in correlation with venous and arterial thrombotic events. As there were limited data on these polymorphisms from Iranian population, we studied the correlation of factor XIIIA-Val34Leu and factor XIIIB-His95Arg with venous thromboembolism (VTE) in central Iran. Venous blood was ...
Lambrecht Stijn S Ghent University, Ghent, - - 2014
Transforming growth factor β superfamily members are involved in the pathogenesis of systemic sclerosis (SSc). Growth differentiation factor 15 (GDF-15) is a distant member of this family. We undertook this study to evaluate the role of GDF-15 in SSc pathogenesis. A longitudinal prospective cohort of SSc patients was screened for ...
Lee Jong Hwa JH Department of Physical Medicine and Rehabilitation and Regional Cardiocerebrovascular Center, Dong-A University Hospital, Busan, - - 2014
To demonstrate associating factors regarding nasogastric tube (NGT) removal in patients with dysphagia after stroke. This study is a retrospective medical chart review. Patients were divided into non-brain stem (NBS) and brain stem (BS) groups. A videofluoroscopic swallowing study was conducted until swallowing functions were recovered. Initial disease status was ...
Guddati Achuta K AK aDepartment of Internal Medicine, Massachusetts General Hospital, Harvard Medical School bDivision of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Factor II inhibitors have been associated with an increased risk of bleeding. The management of patients with factor II inhibitors has not been adequately described. We describe a patient with an increased bleeding tendency due to factor II inhibitor who was unable to undergo surgery due to her bleeding tendency. ...
Zahedpanah Mahdi - - 2014
Introduction Hypercoagulable state is one of the common findings in beta-thalassemia intermedia (β-TI), particularly in splenectomized patients, with infrequent blood transfusion. Abnormality of the red blood cells (RBC) membrane due to oxidative damage is suggestive of possible etiologies. Membrane lipid peroxidation increases the exposure of phosphatidylserine (PS) that plays a ...
Zhang Xiaobin X Department of Psychiatry, Affiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou, - - 2014
Some evidence suggests that neurotrophic growth factor systems might be involved in the etiology of major depressive disorder (MDD). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor from the transforming growth factor-β family that plays a role in the development and function of the brain. This study aimed ...
Atsukawa Masanori M Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh - - 2014
Much is unknown about the effect of 25-hydroxyvitamin D3 levels on the outcome of pegylated-interferon/ribavirin (peg-IFN/RBV) therapy for hepatitis C virus related cirrhosis. The purpose of the present study was to analyze and elucidate factors, including 25-hydroxyvitamin D3 , that contribute to a sustained virological response (SVR) in patients with ...
Bowry Ritvij R From the Department of Neurology, The University of Texas Medical School, Houston (R.B., S.F., J.M.A.-L., S.A.P., J.C.G.); and Center for Clinical and Translational Sciences, University of Texas at Houston (C.C., - - 2014
Factor Xa inhibitors are prescribed for stroke prevention in atrial fibrillation. Managing such patients is challenging especially if they are eligible for thrombolysis because there is no rapidly available test to detect the effect of such medications. Thrombelastography analyzes the dynamics of coagulation and can be rapidly performed. We sought ...
Pagoldh Maria M aDepartment of Internal Medicine and Geriatrics, Sahlgrenska University Hospital/Östra Hospital bInstitute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Göteborg cDepartment of Gastroenterology and Hepatology, Division of Gastroenterology, Karolinska Institute, Karolinska University Hospital dDepartment of Dental Medicine, Division of Periodontology, Karolinska Institute, Stockholm, - - 2014
Ulcerative colitis is a chronic inflammation limited to the large bowel. Early identification of reliable predictive markers addressing the risk of need for colectomy in a severe attack of ulcerative colitis is of crucial importance. To evaluate faecal characteristics and peripheral blood tests as predictive markers for subsequent risk of ...
Högler Wolfgang W Dept of Endocrinology and Diabetes, Birmingham Children's Hospital, - - 2014
Context: Acid labile subunit (ALS) deficiency, caused by IGFALS mutations, is a sub-type of primary IGF-I deficiency (PIGFD) and has been associated with insulin resistance (IR) and osteopenia. Whether patients respond to recombinant human IGF-I (rhIGF-I) is unknown. Objective and Design: This study determined the 14-hour pharmacokinetic (PK) response of ...
Renna Rosaria R Department of Neurology, Institute of Neurology, Catholic University, Rome, Italy. Electronic address: - - 2014
Approximately 10%-14% of ischemic strokes occur in young adults. To investigate risk factors and etiologies of strokes of young adults admitted to the "stroke unit" of Policlinico "Gemelli" of Rome from December 2005 to January 2013. In all, 150 consecutive patients younger than 50 years diagnosed with ischemic stroke were enrolled. Clinical ...
Ahluwalia Jasmina J Dept of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2014
Paroxysmal nocturnal hemoglobinuria(PNH) may present as cytopenia, hemolysis or thrombosis at unusual sites including splanchnic vessels. Thrombosis of the portal veins and hepatic veins are associated with thrombophilic risk factors -deficiencies of Protein C, S and antithrombin, positivity for antiphospholipid antibodies and Factor V Leiden mutation. There is limited information ...
Yu Tu-Nan TN Tu-Nan Yu, Bo Shen, Ning Meng, Hong Yu, Xiu-Jun Cai, The Second Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, - - 2014
To explore risk factors of lymphatic metastasis (LM) in gallbladder cancer, and their potential to complement unsatisfactory radiological detection. Radiological detection of LM by computed tomography (CT) was reported to fail in more than 60% of patients with pathological LM. In order to find risk factors highly suggestive of LM ...
Owczarek Danuta D Danuta Owczarek, Dorota Cibor, Mikołaj K Głowacki, Tomasz Mach, Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, 31-531 Kraków, - - 2014
Hypercoagulability observed in patients with inflammatory bowel diseases (IBD) may lead to thromboembolic events (TE), which affect the venous and arterial systems alike and are an important factor in patients' morbidity and mortality. The risk of TE in IBD patients has been demonstrated to be approximately three-fold higher as compared ...
Dunham C Michael CM Trauma/Critical Services, St, Elizabeth Health Center, 1044 Belmont Avenue, Youngstown, OH 44501, USA. - - 2014
Thromboelastography® (TEG) utilizes kaolin, an intrinsic pathway activator, to assess clotting function. Recent published studies suggest that TEG results are commonly normal in patients receiving warfarin, despite an increased International Normalized Ratio (INR). Because RapidTEG™ includes tissue factor, an extrinsic pathway activator, as well as kaolin, we hypothesized that RapidTEG ...
Ciriza-de-Los-Ríos C - - 2014
Background: High-resolution manometry (HRM) is a breakthrough in the morphological study of the gastroesophageal junction (GEJ) and its degrees of disruption.Objectives: a) Assessment of risk factors involved in the disruption of the GEJ in patients with gastroesophageal reflux (GER) symptoms; b) the relationship between the type of GEJ and GER ...
Sola-Vera J - - 2014
Background: Various studies and two meta-analysis have shown that a variable stiffness colonoscope improves cecal intubation rate. However, there are few studies on how this colonoscope should be used.Objective: The aim of this study was to identify factors related to the advancement of the colonoscope when the variable stiffness function ...
Van Dreden Patrick P Diagnostica Stago, 125 Avenue Louis Roche, 92635 Gennevilliers Cedex, - - 2014
Brain contains large amounts of tissue factor, the major initiator of the coagulation cascade. Neuronal apoptosis after intracerebral haemorrhage (ICH) leads to the shedding of procoagulant phospholipids (PPLs). The aim of this study was to investigate the generation of PPL, tissue factor activity (TFa), and D-Dimer (D-Di) in the cerebrospinal ...
Umemura Atsushi A Clinical Research Center, National Hospital of Utano, Kyoto, Japan; Department of Neurology, National Hospital of Utano, Kyoto, - - 2014
In Parkinson disease (PD), systemic inflammation caused by respiratory infections such as pneumonia frequently occurs, often resulting in delirium in the advanced stages of this disease. Delirium can lead to cognitive and functional decline, institutionalization, and mortality, especially in the elderly. Inflammation causes rapid worsening of PD motor symptoms and ...
Bianchini Marcello M Department of Gastroenterology, Azienda Ospedaliero-Universitaria di Modena, University of Modena and Reggio Emilia, Modena, - - 2014
Coagulopathy in cirrhosis is a composite condition where liver synthetic deficit rebalances coagulation to a parallel reduction of both pro- and anticoagulant factors. Cirrhosis is therefore no longer considered a hypocoagulable state but rather a more unstable hemostatic balance with a lower threshold for tipping toward thrombosis or bleeding. Tendency ...
Hagag Adel A AA Pediatrics Department, Faculty of Medicine, Tanta University, - - 2014
Sickle cell disease has a worldwide distribution. Vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease. Thrombospondin (TSP1) and Placenta growth factor (PlGF) have been reported to be involved in sickle cell diseases (SCD). The aim of this study was to assess the clinical significance ...
Paladino Nunzia Cinzia - - 2013
The aim of this retrospective study was to evaluate the impact of some risk factors on mortality in patients with Acute mesenteric ischemia (AMI). From September 2003 to August 2011, 200 patients were operated on for bowel infarction at our unit: 149 were included in the study. For each patient, ...
Vellimana Ananth K AK 1Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA 2Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA 3Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, - - 2013
Carotid endarterectomy (CEA) for symptomatic carotid artery stenosis and intravenous tPA (IV-tPA) for acute ischemic stroke are proven therapies; however, the safety of CEA in stroke patients who recently received IV-tPA has not been established. To evaluate the safety of CEA in stroke patients who recently received IV-tPA. A retrospective ...
Gondo Tatsuo - - 2013
The risk factors of incisional surgical site infection (iSSI) after open radical cystectomy (ORC) have not been fully investigated. The aim of the present study is to examine factors correlated with iSSI development after ORC with intestinal urinary diversion. A total of 178 patients who had undergone ORC with intestinal ...
Noma Hidetaka - - 2013
The association of inflammatory factors and the aqueous flare value with macular edema in central retinal vein occlusion (CRVO) patients remains unclear. We investigated the relations between the aqueous flare value and vitreous levels of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and interleukin-6 (IL-6) in patients ...
Oi Hidekazu - - 2013
The purpose of this study was to evaluate the possibility of establishing predictors of mortality in women with amniotic fluid embolism. Our previous report identified eight factors associated with amniotic fluid embolism (AFE) fatality: dyspnea, cardiac arrest, loss of consciousness, serum sialyl Tn greater than 47 U/mL, serum interleukin-8 greater than ...
Bilgir Oktay - - 2013
In a majority of patients with nonalcoholic fatty liver disease (NAFLD), cardiovascular risk factors including diabetes mellitus type 2, abdominal obesity, and metabolic syndrome are present. The purpose of this study is to investigate the presence of endothelial injury and the changes in coagulation parameters in NAFLD patients. For this ...
Araujo Antonio Santos de AS Junior Hospital Sírio-Libanês, Brazil, Sao - - 2013
Decompressive craniectomy (DC) is gaining an increasing role in the neurosurgical treatment of intractable intracranial hypertension, but not without complications. A rare complication is the "syndrome of the trephined" (ST). It occurs when the forces of gravity overwhelm intracranial pressures, leading the brain to become sunken. Objective To determine the ...
Girolami A A Department of Medicine, University of Padua Medical School, Padua, - - 2013
Congenital Factor VII (FVII) deficiency can be divided into two groups: cases of "true" deficiency, or cross-reactive material (CRM) negative and variants that are cross-reactive material positive.The first form is commonly recognized as Type I condition whereas the second one is known as Type II. FVII deficiency has been occasionally ...
Dutta Mainak M RMO-cum-Clinical Tutor, Department of Otorhinolaryngology and Head-Neck Surgery, Medical College and Hospital , Kolkata, India - - 2013
Recurrent Acute Exacerbations of Chronic Rhinosinusitis (AECRS) in a setting of atrophic rhinitis are perplexing clinical situations. While either may act as the primary factor, repeated inflammation in a vessel-poor atrophied tissue is unusual. Progressive mucosal degeneration, vascularity and the effect of bacterial colonization are the factors suggested to play ...
Giugliano Emilio E Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Corso Giovecca 183, 44121 Ferrara, - - 2014
To assess how some factors may influence the failure of labor induction. We conducted a prospective observational study from January 2009 to December 2011 with 248 patients who were admitted to the Obstetrics Unit of Ferrara University for labor induction. We selected only patients with unfavorable characteristics such as nulliparity, ...
Kim Young-Soo YS Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South - - 2013
Hyponatremia is one of the most common adverse effects in patients treated with oxcarbazepine (OXC). Most patients with OXC-induced hyponatremia are asymptomatic, so the presence of severe or symptomatic hyponatremia, which requires electrolyte correction or discontinuation of OXC therapy, has more important clinically implications. However, data for OXC-induced severe and ...
Castejon Raquel - - 2013
Objective. Endothelial progenitor cells (EPCs) play an important role in vascular damage repair and it has been suggested that a decreased number of these cells is associated with increased subclinical atherosclerosis. Our study aim was to evaluate whether the number of circulating EPCs in patients with SLE is associated with ...
Sarkar Esha - - 2013
Complement dysregulation from an uncontrolled activation of the alternate pathway can be mediated by C3 Nephritic Factor and results in C3 glomerulopathy. Identification of C3 degradation products C3c and C3d in patient serum provides evidence of uncontrolled complement activation. It is possible to detect C3c and C3d in patient serum ...
Avila-Díaz Marcela - - 2013
Cardiac valve calcification (VC) is a frequent complication in chronic renal disease and is considered a risk factor for all-cause and cardiovascular mortality. However, little is known about the pathophysiology mechanisms that originate it and the factors associated with its development. We undertook this study to analyze the frequency and ...
Azuma Naoto - - 2013
Objective. To assess changes in salivary epidermal growth factor (EGF) levels and the correlation between these levels and the severity of intraoral manifestations in Sjögren's syndrome (SS). Methods. Forty SS patients and 23 controls were enrolled. Salivary EGF concentration was measured using an enzyme-linked immunosorbent assay, and intraoral manifestations were ...
Janning M - - 2013
Background: Acquired factor XIII (FXIII) deficiency is associated with reduced clot firmness and increased bleeding in patients undergoing major surgery. In contrast, only limited information is available on the haemostatic relevance of acquired FXIII deficiency in non-surgical patients. Case report: An 81-year-old patient, who had experienced acute type-A dissection of ...
Vlajinac Hristina - - 2013
The aim of the study was to determine the factors related to venous ulceration. Patients with venous ulceration (278 patients) were compared with 1401 patients in other categories of clinical classification of venous disease (clinical, etiologic, anatomic, and pathophysiological [CEAP]). Demographic, anthropometric, and clinical data were collected. Univariate and multivariate ...
Habib Mohamed - - 2013
Patients with liver disease often show profound abnormalities in their haemostatic system. Studies using thrombin generation demonstrate rebalanced coagulation in patients with chronic liver disease. Our aim was to evaluate the haemostatic profile in patients with acute liver injury/failure (ALI/ALF) compared to healthy controls. Thrombin generation was measured in the ...
Haerynck Filomeen - - 2013
Complement regulators control the activated complement system. Defects in this homeostasis can result in tissue damage and autoimmune diseases with a heterogeneity in clinical presentation. Complement factor I (FI), a serine protease, is an important regulator of alternative pathway activation. We report a diagnostic work-up of a patient with relapsing ...
Reinhard Mark - - 2013
Patients on maintenance hemodialysis (HD) have reduced circulating free and bioactive insulin-like growth factor I (IGF-I) due to increased IGF-binding proteins (IGFBPs). The present study investigated the postprandial response of the IGF system in HD patients compared with matched healthy subjects. In a cross-over study, twelve non-diabetic HD patients were ...
Ujigo Satoshi - - 2013
Benign schwannoma is the most common tumor of peripheral nerves. However, the clinical course of excision and risk factors associated with postoperative neurological deficits are not well known. We evaluated the incidence of preoperative symptoms, the incidence of postoperative neurological deficits, and the risk factors of neurological deficits. We retrospectively ...
Strohmaier Walter Ludwig - - 2013
Metabolic evaluation is not suitable to forecast the course of the disease in idiopathic calcium oxalate stone formation (iCaOxU). An important pathway in CaOx stone formation is the overgrowth on interstitial apatite papillary plaques. Therefore, we studied whether the extent of such plaques may be used as a prognostic factor ...
Perez-Mora Nicolas N Medical Science Research, Svenson Medical, Madrid, - - 2013
Acute telogen effluvium (ATE) is often associated with female androgenetic alopecia (FAA), but predictive factors of ATE-FAA association and clinical factors or therapies that may influence the progression of ATE to chronic telogen effluvium (CTE) have not been reported. We have identified predictive factors of ATE-FAA association and retrospectively evaluated ...
Tu Qiuyun - - 2013
The objectives of the study were to explore the prevalence and effects of vascular cognitive impairment (VCI) among ischemic stroke patients and to provide a basis for prevention and treatment strategies. A stratified cluster random sampling method was performed, and 689 ischemic stroke patients (over 40 years of age) were ...
Palmero-Fernández L - - 2013
An alcoholic patient with loss of vision in his right eye and a peripapillar haemorrhage, who then presented with a venous thrombosis. Blood analysis revealed hyperhomocysteinemia with coagulation parameters within the normal range. In the follow-up he developed a bilateral optic neuropathy. An increase in homocysteine levels is common in ...
Feng Dengmin - - 2013
Coagulation factor IX (FIX) a plasma protein whose absence results in hemophilia B, a disease ameliorated by injection of FIX. The pharmacokinetics of infused FIX are complicated. Fifty-80% of injected FIX disappears within 5 minutes.[1-3] Furthermore, Briet has observed that FIX injected into hemophilia B patients lacking antigen disappears more ...
Shojaee Semira - - 2013
Transforming growth factor-β1 (TGF-β1) plays a major role in pleural fibrosis and chemical pleurodesis. Approximately 50% of patients with tunneled pleural catheters (TPCs) for malignant pleural effusions (MPEs) will have autopleurodesis. Pleural TGF-β1 levels have never been measured in the setting of TPC drainage and may predict autopleurodesis. Pleural fluid ...
Nitta Hidetoshi - - 2013
Background/Aims: We investigated the postoperative outcome and risk factors for DIC and mortality in cases of implanted PVS. Methodology: We reviewed the cases of 65 patients implanted with PVS from 2000 to 2010. Of these patients, 32 were diagnosed with peritonitis carcinomatosa, 21 had liver cirrhosis with hepatocellular carcinoma (HCC), ...
Dooki Mohammad-Reza Esmaeili MR Pediatric Gastroenterologist, Non-Communicable Pediatric Diseases Research Center, Babol, - - 2013
Cholelithiasis rarely occurs in children but the increased use of ultrasonography has led to increased detection of gallstones in patients. The epidemiology and predisposing factors of cholelithiasis vary in different populations. The aim of this study was to describe the clinical presentation, predisposing factors and to evaluate management and outcome ...
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