Search Results
Results 251 - 300 of 1582
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Sivakumar Tharsan - - 2010
BACKGROUND: Resistance to thyroid hormone (RTH) is a rare disorder in which an abnormality in the binding domain of the thyroid hormone receptor results in end-organ insensitivity to the actions of thyroid hormones. This disorder is sometimes misdiagnosed as Graves' disease due to the presence of a goiter with high ...
Kim Won Gu - - 2010
The simultaneous occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland is documented. In this study, we evaluated the prevalence and characteristics of patients with concurrent MTC and PTC. Design Retrospective analysis of patients with MTC in a single centre and review of ...
Kim Eui Young - - 2010
To evaluate the clinical outcomes of persistent radioiodine uptake (RAIU) in the neck by diagnostic whole body scan (DxWBS) after initial therapy and the efficacy of the second ablation in patients with differentiated thyroid carcinoma (DTC). Patients with DTC who underwent bilateral surgery and high-dose remnant ablation between 2000 and ...
Kim Won Gu - - 2010
Context: Some patients with elevated serum thyroglobulin (Tg) but a negative diagnostic whole body scan (WBS) after initial therapy for differentiated thyroid carcinoma may benefit from empirical radioactive iodine (RAI) therapy. However, previous studies enrolled patients with negative diagnostic WBS, regardless of neck ultrasonography (USG) and/or (18)F-fluorodeoxyglucose positron emission tomography ...
Kozaki Ai - - 2010
PURPOSE.: This observational case series investigated the occurrence and distribution of proptosis in Japanese patients with dysthyroid ophthalmopathy (DO). The relationship among lid retraction, lid swelling, and enlargement of extraocular muscles was also analyzed. METHODS.: From 1993 to 2002, 10 931 patients (2240 men and 8691 women, average age; 39.9 ...
Wells Samuel A SA - - 2010
PURPOSE There is no effective therapy for patients with distant metastasis of medullary thyroid carcinoma (MTC). Activating mutations in the RET proto-oncogene cause hereditary MTC, which provides a strong therapeutic rationale for targeting RET kinase activity. This open-label, phase II study assessed the efficacy of vandetanib, a selective oral inhibitor ...
Cohen-Lehman Janna - - 2010
Amiodarone is a benzofuran derivative approved for the treatment of cardiac arrhythmias. Traditionally classified as a class III antiarrhythmic agent, amiodarone possesses electrophysiologic properties of all four Vaughan-Williams classes. This drug, however, has high iodine content, and this feature plus the intrinsic effects on the body make amiodarone especially toxic ...
Consorti F - - 2010
Many studies have investigated the association between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC), but clinical management of this condition has never been addressed specifically, even in recent guidelines. Surprisingly the likelihood of a nodule as being cancerous in a CLT has never been explicitly expressed in terms ...
Jansa P - - 2010
Oral anticoagulant therapy is recommended for patients with pulmonary arterial hypertension (PAH). The rationale for the use of anticoagulant treatment is based on thrombophylic predisposition in PAH and improvement of survival in patients treated with anticoagulation. However, the target INR value has not been evaluated. The aim of this study ...
Jeong Seul-Ki - - 2010
Thyroid dysfunction has been known to be closely associated with increased vascular events. The aims of the present study included determining the prevalence of subclinical thyroid disease and relationships between normal ranges of thyroid function and internal carotid artery steno-occlusion (ICS) in patients with ischemic stroke. From March 2007 to ...
Kakuno Yoko - - 2010
The prevalence of menstrual disturbances, including secondary amenorrhea, hypomenorrhea, oligomenorrhea, hypermenorrhea, polymenorrhea and irregular menstrual cycle were prospectively examined in 586 patients with hyperthyroidism due to Graves' disease, 111 with hypothyroidism, 558 with euthyroid chronic thyroiditis, 202 with painless thyroiditis and 595 with thyroid tumor. In the overall patient group, ...
Gulben K - - 2010
Some patients with differentiated thyroid cancer (DTC) have high serum thyroglobulin (Tg) levels although no evidence of disease can be detected on radioiodine scanning or other imaging methods. The aim of this study is to determine whether a gradient exists between the Tg levels of venous samples adjacent to primary ...
Zagrodzki Pawe? - - 2010
OBJECTIVE: To examine the correlation structure of parameters expressing selenium status, sex hormones secretion and thyroid function in a group of patients with Hashimoto disease and healthy female subjects. METHOD: Partial Least Square modeling was applied to parameters under study. RESULTS: The correlations between relevant parameters were confirmed. Selenoenzyme glutathione ...
Adams O Peter - - 2010
About 55% of the population 40 to 80 years of age in Barbados is hypertensive. The quality of hypertension primary care compared to available practice guidelines is uncertain. Charts of hypertensive and diabetic patients were randomly sampled at all public and 20 private sector primary care clinics. Charts of all ...
Paravar Taraneh - - 2010
BACKGROUND: Vitiligo is a depigmenting disease of unknown etiology. A more complete understanding of vitiligo and associated conditions will provide better insight into the etiology and potential treatment options for this condition. We sought to gather information regarding associated conditions and other epidemiologic data on vitiligo. METHODS: A retrospective chart ...
Uchida Toyoyoshi - - 2010
Thyrotoxicosis with diffuse thyroid disease can be caused by Graves' disease (GD) or destructive thyroiditis (DT). Optimal treatment of the underlying condition requires a prompt and accurate method for the diagnosis of thyrotoxicosis. This study evaluated measurement of the mean peak systolic velocity of the superior thyroid artery (STA-PSV) by ...
Cross Graciela - - 2010
In the familial form of papillary thyroid cancer (PTC), two or more members of the same family have to be affected with PTC. Prevalence is around 5% of all PTC. We performed a clinical analysis in 79 relatives of 16 patients of 7 unrelated kindred with the diagnosis of familial ...
De Reuck J - - 2010
Arterial hypertension (AH) is one of the most important vascular risk factors for stroke that can be treated. The present retrospective study analyses the influence of pretreated AH on the outcome of patients with ischaemic and haemorrhagic strokes, compared to those with normal blood pressure (BP). The demographic features, vascular ...
Lee Jandee - - 2010
OBJECTIVES: Distant metastasis (DM) is seldom observed at initial presentation of differentiated thyroid carcinoma (DTC), making it difficult to assess the clinical characteristics and treatment outcomes of DTC patients with DM. We therefore retrospectively assessed these parameters in DTC patients who presented with DM between July 1994 and December 2007. ...
Ito Yasuhiro - - 2010
Distant metastasis (DM) at surgery is a prominent prognostic factor in patients with papillary carcinoma of the thyroid. However, the clinical outcomes of these patients (M1 patients) remain unclear. In this study, we investigated the prognosis and prognostic factors of M1 patients. Seventy-one of 5969 patients who underwent initial surgery ...
Bossowski A - - 2010
The aim of this study was to estimate sodium iodide symporter (NIS) and thyroid peroxidase (TPO) expression in thyrocytes from patients with GD and no-toxic multinodular goitre (NTMG) in relationship with apoptotic (TIAR and TIA-1) markers. The investigation was performed on thyroid cells isolated from postoperation thyroid tissues from 15 ...
Kim Jung Min - - 2010
BACKGROUND: Serum calcitonin is the most useful tumor marker for the diagnosis and follow-up of medullary thyroid carcinoma (MTC). Spurious hypercalcitoninemia caused by heterophilic antibody interference (HAI) is rarely found in patients without MTC. METHODS: We studied 2 patients with hypercalcitoninemia and thyroid nodules, but no evidence of MTC on ...
Eid Wael E - - 2010
OBJECTIVE: To develop a receiver operating characteristic (ROC) curve of glycosylated hemoglobin (HbA1c) for diagnosing diabetes mellitus within a chronic disease management system. METHODS: A case-control study including medical records from January 1, 1997, to December 31, 2005, was conducted at the Sioux Falls Veterans Affairs Medical Center. Medical records ...
Gul Kamile - - 2010
OBJECTIVE: To evaluate the occurrence of thyroid disease in patients undergoing parathyroidectomy for primary hyperparathyroidism. METHODS: In this case series, records of all patients with a diagnosis of primary hyperparathyroidism who underwent parathyroidectomy between January 2005 and December 2008 in our clinic were analyzed retrospectively. Preoperatively, all patients were evaluated ...
Podoba J - - 2010
BACKGROUND: Despite very good prognosis patients with previously treated well-differentiated thyroid cancer (DTC) require lifelong monitoring for recurrent disease. Apart from neck ultrasonography (USG) two diagnostic tests play a central role in follow-up of these patients: radioiodine whole body scanning and serum thyroglobulin (Tg) measurement. The diagnostic value of both ...
Romano Minna M D - - 2010
Structural myocardial abnormalities have been extensively documented in hypothyroidism. Experimental studies in animal models have also shown involvement of thyroid hormones in gene expression of myocardial collagen. This study was planned to investigate the ability of ultrasonic tissue characterization, as evaluated by integrated backscatter (IBS), to early identify myocardial involvement ...
Ardito Guglielmo - - 2010
Total thyroidectomy is the treatment of choice in the majority of thyroid malignancies, preventing the risk of reoperative surgery due to recurrences. In order to assess the usefulness of such an approach, expression levels of inflammatory and proliferative markers were evaluated immunohistochemically in non-lesional adjacent thyroid tissues from a group ...
Tamagno Gianluca - - 2010
The encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concentration, non-specific electroencephalogram abnormalities, and responsiveness to the corticosteroid treatment in patients with an autoimmune thyroid disease. Almost all EAATD patients are affected by Hashimoto's thyroiditis (HT), although ...
Wright-Pascoe Rosemarie A - - 2010
To describe the clinical characteristics of patients with spontaneous hypothyroidism, the frequency of chronic autoimmune thyroiditis, and the thyroid autoantibody most often associated with this condition in a referral population in Jamaica. A retrospective study of all cases referred to the author's endocrinology practice from 1995 to 2005 with a ...
Antonelli Alessandro - - 2010
The association of systemic lupus erythematosus (SLE) and thyroid autoimmunity has been reported by several studies in a wide range of variability. However, from a review of the literature, discrepant results have been reported. The aim of the study was to evaluate the prevalence of clinical and subclinical thyroid disorders ...
Satoh Mari - - 2010
BACKGROUND: Previous studies have reported a high prevalence of autoimmune thyroid disease (AITD) in adult patients with pulmonary arterial hypertension (PAH). The aim of this retrospective study was to determine the prevalence of AITD in children and adolescents with idiopathic PAH (IPAH). METHODS AND RESULTS: The study group included 16 ...
De Luca Filippo - - 2010
OBJECTIVE: To compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively. DESIGN AND METHODS: The evolution over time of GD was determined in both groups according to the clinical changes and ...
Gul K - - 2009
AIM: The aim of this study was to determine the frequency of thyroid carcinoma in patients with hyperthyroidism and evaluate the role of preoperative ultrasonography (US) guided thyroid fine needle aspiration biopsy (FNAB) in diagnosis of thyroid carcinoma in these patients. METHODS: Three hundred twenty-five hyperthyroid patients--119 with toxic multinodular ...
Monchik Jack M - - 2009
BACKGROUND: There is controversy regarding the need for prophylactic level VI central node dissection in patients with low-risk papillary thyroid carcinoma (PTC). This study focuses on the incidence of persistent level VI nodal disease in low-risk PTC without prophylactic central node dissection. METHODS: PTC was known at the time of ...
Su Shirley Y - - 2009
OBJECTIVE: To investigate the incidence, time to onset, and risk factors for the development of hypothyroidism after hemithyroidectomy. BACKGROUND: The incidence and risk factors for hypothyroidism in patients undergoing partial thyroid surgery remains unclear. Hypothyroidism is an under appreciated sequel of hemithyroidectomy. The early recognition of this postoperative complication may ...
Kim Suk Jae - - 2010
BACKGROUND AND PURPOSE: To investigate the association between thyroid autoantibodies and moyamoya disease (MMD) in patients with an apparent euthyroid state. METHODS: We prospectively studied angiographically diagnosed patients with MMD. We compared demographic profiles, thyroid function test, and thyroid autoantibody status between MMD and control groups. RESULTS: A total of ...
Rosenbaum Michael A - - 2009
OBJECTIVE: To examine the role of central neck dissection (CND) in patients with papillary thyroid cancer (PTC). DESIGN: Retrospective analysis of patients treated for PTC between 1993 and 2008. SETTING: Academic institution. PATIENTS: All patients diagnosed with PTC who underwent surgical therapy at our institution. MAIN OUTCOME MEASURES: Recurrence, hypocalcemia, ...
Gierach Marcin - - 2009
INTRODUCTION: The aim of the study was to estimate the influence of nicotine on thyroid volume according to patients' sex. MATERIAL AND METHODS: A group of 160 patients with thyroid disorders in their past medical history was examined. Patients were divided into two groups: Group A contained 50 patients with ...
de Araujo-Filho Vergilius Jos?? Furtado - - 2009
BACKGROUND: The vascular endothelial growth factor (VEGF) is a major promoter of endothelial growth and migration. Some studies have shown a correlation between expression of this growth factor and prognosis in several cancers, including well-differentiated thyroid cancer. AIM: We studied VEGF expression, local invasiveness, and other prognostic factors in papillary ...
Stagi Stefano - - 2010
INTRODUCTION: Monoallelic microdeletion of chromosome 22q11 (22q11DS) is considered to be the commonest human microdeletion syndrome. Abnormalities of thyroid function are sporadically reported in this syndrome, but very few studies have specifically assessed this issue, and thyroid morphology has not been systematically studied. DESIGN: To evaluate the prevalence of abnormalities ...
Tala Jury Hernan P - - 2010
BACKGROUND: Low-iodine diet is prescribed before (131)I administration in patients with differentiated thyroid cancer, although no study has properly quantified its clinical benefit. OBJECTIVE: Our study aimed to evaluate the association between urinary iodine excretion (UIE) and (131)I ablation by correlating UIE with the rate of successful ablation. PATIENTS: We ...
Erdogan Mehmet - - 2009
We investigated the demographic and clinical features of patients with Hashimoto's thyroiditis who had been diagnosed and treated in Ege University, the main referral center in the Aegean region of Turkey. Medical records of patients who had been followed in the endocrinology clinic of Ege University were retrospectively evaluated. Patients ...
Elisei R - - 2009
BACKGROUND: We previously demonstrated comparable thyroid remnant ablation rates in postoperative low-risk thyroid cancer patients prepared for administration of 3.7GBq (131)I (100 mCi) after recombinant human (rh) TSH during T(4) (L-T4) therapy vs. withholding L-T4 (euthyroid vs. hypothyroid groups). We now compared the outcomes of these patients 3.7 yr later. ...
Ruchala Marek - - 2010
OBJECTIVE: Thyroid hemiagenesis (THA) is an anomaly resulting from the developmental failure of one thyroid lobe. Etiopathogenesis, clinical significance, and management of patients in whom THA is diagnosed are still a matter of debate. The aim of the study is to provide the first systematic analysis of a large cohort ...
Yoon Jin Sook - - 2010
PURPOSE: To measure tear nerve growth factor (NGF) concentrations in cases of active thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid treatment, and to correlate NGF levels with disease inflammatory activity and thyroid autoantibody concentration. METHODS: The study involved 20 patients with active TAO and 20 age- and gender-matched controls. Tear ...
Gu Li-qun - - 2009
Graves' disease (GD) is an autoimmune disorder, and the most common extrathyroidal manifestation is Graves' ophthalmopathy (GO), which is believed to be caused by a complex interaction between genetic and environmental factors. Many studies have reported that interleukin-8 (IL-8), a potent pro-inflammatory cytokine, is associated with many autoimmune diseases and ...
Traino Antonio C - - 2010
OBJECTIVE: In Graves' disease therapy, the amount of (131)I is usually decided following two different modalities: the administration of a fixed activity or of an activity individually calculated based on a fixed value of target absorbed dose. Although the effectiveness of each of these approaches is good (about 80% of ...
Van Nostrand Douglas - - 2009
BACKGROUND: Dosimetry has been used to help identify when empiric dosages of 131-I treatment for suspected metastatic well-differentiated thyroid carcinoma (WDTC) may be increased or should be decreased, but dosimetry is complex, and easier approaches would be useful. The three objectives of this study were to assess the utility of ...
Lau Gregory S K - - 2009
To evaluate the impact of genetic testing in the management of familial multiple endocrine neoplasia 2A patients. Retrospective study. University teaching hospital, Hong Kong. Twenty-two patients from eight multiple endocrine neoplasia 2A families underwent prophylactic total thyroidectomy based on a positive RET mutation genetic testing. All mutations were located at ...
Zucchelli G - - 2009
Determination of thyroglobulin (Tg) in serum represents a key element in the follow-up of patients treated for differentiated thyroid cancer (DTC). The sensitivity and the specificity of the assay strongly affects the clinical impact. Most of patients are disease-free after thyroidectomy and iodine radioablation; 15% of them show over time ...
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