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Results 101 - 150 of 909
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Fern?ndez Adolfo A - - 2009
The delay time of the Hb S polymerization process was investigated in 63 patients with sickle cell disease during steady state and 10 during painful crisis starting from spin-spin proton magnetic resonance (PMR) time behavior measured at 36 degrees C and during spontaneous deoxygenation. We found a significant decrease of ...
Passweg Jakob R - - 2008
Here we summarize data on hematopoietic stem cell transplantation (HSCT) to treat severe, refractory, hematologic autoimmune cytopenia. In the last 10 years, limited experience has been gained with the use of HSCT for hematologic disease. A phase II study by the NIH has presented data on autologous HSCT in 14 ...
Escoresca Ortega A M - - 2008
BACKGROUND: A recent study proposed a risk index (McCluskey index) based on 7 parameters to identify the transfusion needs of patients during surgery and in the first 24 hours postoperation. The initial objective of our study was to validate this predictor for blood product transfusions. PATIENTS AND METHODS: We undertook ...
Foley Robert N - - 2008
Optimal hemoglobin targets for chronic kidney disease patients receiving erythropoiesis-stimulating agents remain controversial. The effects of different hemoglobin targets on blood transfusion requirements have not been well characterized, despite their relevance to clinical decision-making. Five hundred ninety-six incident hemodialysis patients without symptomatic cardiac disease were randomly assigned to hemoglobin targets ...
Sidani Charif A - - 2008
A 21-year-old man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigation did not reveal any inherited or acquired hypercoagulable state. This ...
Hamidah A - - 2008
Growth impairment is commonly seen in children with thalassemia despite regular blood transfusions and desferrioxamine treatments. We investigated the growth velocity of 26 prepubertal patients with beta-thalassemia or HbE-beta thalassemia who were transfusion dependent aged between 2 and 13 years. The prevalence of impaired growth velocity (ie, growth velocity less ...
Balci Ali - - 2008
PURPOSE: The aim of this study was to evaluate the type and prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease. MATERIALS AND METHODS: A total of 102 patients with sickle cell disease at the Center of Hemoglobinopathy of the Antakya State Hospital were screened for intra-abdominal abnormalities ...
Dmytrijuk Andrew A Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. - - 2008
On March 16, 2007, eculizumab (Soliris; Alexion Pharmaceuticals, Inc. Cheshire, CT), a humanized monoclonal antibody that binds to the human C5 complement protein, received accelerated approval by the U.S. Food and Drug Administration for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis. Eculizumab was studied in ...
Kramer Andreas H - - 2008
OBJECTIVE: Patients with subarachnoid hemorrhage (SAH) frequently develop delayed cerebral ischemia and may be especially vulnerable to the effects of anemia. However, the potentially harmful effects of allogeneic red blood cells are increasingly being recognized. The optimal transfusion threshold is unknown, but current practice most often uses a liberal approach. ...
Dulvadestin Philippe - - 2008
BACKGROUND: Patients with sickle cell disease (SCD) frequently undergo surgery during their lifetime. Patients with SCD are considered at greater risk of perioperative complications than otherwise healthy patients and require meticulous anesthetic management. The pharmacodynamics of anesthetics may be altered in patients with SCD due to microcirculatory abnormalities or anemia. ...
Olaniyan, MF; ;
Sixty HbSS sickle cell anaemic patients aged 17.45 ±10.1years (Female=30, Male=30) and sixty HbSC sickle cell disease patients aged 20.6±11.0years(Female=30,Male=30) were recruited for the investigation. Haemoglobin genotype of each of the patient was determined by electrophoresis. HepatitisB‘s' antigen, HBeAg,anti-HBe, and anti-HCV in patients' plasma were determined by Enzyme Immunoassay. The ...
Johansson P I - - 2008
OBJECTIVES: Continued haemorrhage remains a significant contributor to mortality in massively transfused patients. We found that early administration of platelets and plasma reduced mortality from 54% to 36% in rAAA patients. The aim of the present evaluation was to evaluate whether reduced mortality in rAAA patients related to a pro-active ...
Taher Ali T - - 2008
Thalassemia is a congenital hemolytic disease caused by defective globin synthesis resulting in decreased quantity of globin chains. Although the life expectancy of beta-thalassemia patients has markedly improved over the last few years, patients still suffer from many complications of this congenital disease. The presence of a high incidence of ...
Metarugcheep Pichest - - 2008
BACKGROUND: Silent cerebral infarct (SCI) could be detected on magnetic resonance imaging. It seems to be associated with the risk of stroke. Ischemic stroke has been reported in sickle cell anemia. Sickle red cell in hypoxic state associated with hypercoagulopathy is the risk factor of blood vessel occlusion leading to ...
Sullivan Patrick S - - 2008
OBJECTIVE: To evaluate, among anemic patients with HIV, the impact on hemoglobin (Hb) of initiating zidovudine (AZT)-containing and non-AZT-containing combination antiretroviral therapy (cART). METHODS: We used medical records data collected in 11 US cities from 1998 to 2004. Baseline anemia was described as mild (10 < Hb < or = ...
Singh Sharon A - - 2008
Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly after they were ...
Friese Randall S - - 2008
BACKGROUND: Clinical studies suggest that leukocytes in banked blood may increase infectious complications after transfusion. However, these investigations included few injured patients. Therefore, the effect of the use of leukoreduced red blood cell (RBC) products in this patient population is unknown. In addition, large numbers of RBC transfusions are frequently ...
Schubert Jörg J Internal Medicine I, Saarland University Medical School, Homburg Saar, Germany. - - 2008
In paroxysmal nocturnal haemoglobinuria (PNH), chronic destruction of PNH red blood cells (RBCs) by complement leads to anaemia and other serious morbidities. Eculizumab inhibits terminal complement-mediated PNH RBC destruction by targeting C5. In the phase III, double-blind, placebo-controlled, TRIUMPH study, eculizumab reduced haemolysis, stabilized haemoglobin levels, reduced transfusion requirements and ...
Aronson Doron - - 2008
Divergent views remain regarding the safety of treating anemia with red blood cell (RBC) transfusion in patients with acute coronary syndrome (ACS). We used a prospective database to study effect of RBC transfusion in patients with acute myocardial infarction (MI; n = 2,358). Cox regression models were used to determine ...
Billy-Brissac Rachel - - 2009
Pulmonary hypertension (PH) is a severe complication of sickle cell disease (SCD). The main purpose of this study was to evaluate the prevalence of PH in an adult SCD population in Guadeloupe. Echocardiography findings of 427 patients with SCD were analyzed. Subjects with a pulmonary artery systolic pressure (PASP) >30 ...
Sokol Jason A - - 2008
PURPOSE: To present 3 cases of orbital compression syndrome caused by infarction of the greater wing of the sphenoid in patients with sickle cell disease. METHODS: Case report and review of the literature. RESULTS: Three patients with sickle cell disease (2 males aged 22 and 16 years, and a 10-year-old ...
Mehrvar A - - 2008
Thalassemia is common in Iran. Appropriate therapy for this disease includes a regular blood transfusion and chelation therapy. However, in this approach patients will inevitably experience side effects, particularly iron overloads in critical organs, including heart, ductless glands, and liver. This study attempted to determine prevalence of adenoidal abnormality between ...
Gerber David R - - 2008
To review the current literature concerning the utility of and complications associated with transfusion of packed red blood cells (PRBC) in medical and surgical patients with ischemic heart disease. The PubMed database of the National Library of Medicine was searched for all studies investigating the use of PRBC in medical ...
Moore Frederick A - - 2008
BACKGROUND: Severely bleeding trauma patients requiring massive transfusion (MT) often experience poor outcomes. Our purpose was to determine the potential role of near infrared spectrometry derived tissue hemoglobin oxygen saturation (StO2) monitoring in early prediction of MT, and in the identification of those MT patients who will have poor outcomes. ...
- - 2008
To describe temporal trends in baseline clinical characteristics, initial treatment regimens and monitoring of patients starting antiretroviral therapy (ART) in resource-limited settings. We analysed data from 17 ART programmes in 12 countries in sub-Saharan Africa, South America and Asia. Patients aged 16 years or older with documented date of start ...
Wahl Wendy L - - 2008
BACKGROUND: Multiple studies report that patients receiving red blood cell (RBC) transfusion in the intensive care unit (ICU) are more likely to experience complications. Despite these findings, surgical patients are frequently transfused for operative procedures, trauma, and burns. We hypothesized that a RBC transfusion guideline would safely decrease our use ...
Kato Gregory J GJ Critical Care Medicine Department, Clinical Center, NHLBI, NIH, Bethesda, MD 20892-1476, USA. - - 2009
Pulmonary hypertension (PH) in patients with sickle cell disease (SCD) is linked to intravascular haemolysis, impaired nitric oxide bioavailability, renal dysfunction, and early mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthases (NOS), is associated with vascular disease in other populations. We determined the plasma concentrations for several ...
Takayanagi Akio - - 2008
OBJECTIVES: Radical retropubic prostatectomy (RRP) and radical cystectomy (RCx) are well tolerated and widely performed. Because intraoperative blood loss is one of the most common problems, we performed acute normovolemic hemodilution (ANH) to prevent allogenic blood transfusion (ABT). In this study we tried to clarify the safety, effectiveness and problems ...
Di Benedetto Attilio - - 2008
The aim of this study was to verify the importance of continuously monitoring the level of adherence to the anemia guideline recommendations in order to improve not only quality of care but also patient safety. Data presented in this investigation were gained through the FME database EuCliD which contains the ...
Shojaiefard A - - 2008
BACKGROUND: Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by destruction of opsonized platelets in the reticuloendothelial system, particularly the spleen, and by resulting low platelet counts. Splenectomy is the standard second-line treatment for patients with ITP who do not respond to corticosteroids. In the present study we ...
Jabbour Elias - - 2008
BACKGROUND: Approximately 15,000 new cases of myelodysplastic syndromes (MDS) are expected in the United States each year. METHODS: The mainstay for the management of myelodysplastic syndromes (MDS) is supportive therapy with red blood cell (RBC) transfusions to improve the patient's quality of life. RBC transfusions enable adequate tissue oxygenation and ...
Shord Stacy Shifflett - - 2008
A common side effect of opioids is nausea and vomiting; however, the incidence in hospitalized patients receiving opioids for acute pain is unknown. We performed a retrospective study in adult patients with sickle cell disease admitted for an acute pain crisis during a six-month period to evaluate the incidence of ...
Aboudara Matthew C - - 2008
BACKGROUND: Published analyses of clinical outcomes for patients requiring large-volume blood transfusion conflict with respect to the impact upon plasma potassium levels. We analyzed a cohort of trauma patients to ascertain the impact of component product transfusion upon plasma potassium values. METHODS: We performed an observational analysis of previously, prospectively ...
Ibidapo, M O; ;
Background: Sickle cell disorder is characterized by a reduced haemoglobin solubility and consequent polymerization, leading to an increased haemolysis as well as vaso-occlusive complications including priapism. Priapism occurs frequently amongst SCD patients in LUTH, and can be associated with erectile dysfunction (ED). Patients and Methods: A cross-sectional survey of 120 ...
van Beers Eduard J - - 2008
BACKGROUND: Pulmonary hypertension (PHT) occurs in approximately 30% of adult patients with sickle-cell disease (SCD) and is a risk factor for early death. The potential role of pulmonary artery obstruction, whether due to emboli or in situ thrombosis, in the etiology of SCD-related PHT is unknown. METHODS: Consecutive SCD patients ...
Karkouti Keyvan - - 2008
BACKGROUND: Current red blood cell (RBC) transfusion guidelines assume that most acutely anemic patients can tolerate hemoglobin (Hb) concentrations as low as 6.0 to 7.0 g per dL and recommend that range as the transfusion threshold in patients who have no overt signs of organ dysfunction. Nonetheless, "normal" Hb concentrations ...
Bilgin Yavuz M - - 2008
BACKGROUND: Serum levels of mannose-binding lectin (MBL), a recognition molecule of the lectin pathway of complement, are highly variable, based on genetic variation. After cardiac surgery, extracorporeal circulation and ischemia-reperfusion injury initiate a systemic inflammatory response, which can evolve to multiple organ dysfunction syndrome (MODS). Preoperative transfusions of allogeneic white ...
Omoti, C E; ;
The presence of high blood levels of haemoglobin A<sub>2</sub> (HbA<sub>2</sub> ) has been noted in sickle cell anaemia (SCA) patients. This study was designed to determine if there is a relationship between high HbA<sub>2</sub> levels and a reduction in the occurrence of vaso-occlusive crisis, complications and erythrocyte transfusion requirements in ...
S.J. Emam
The aim of this study was to evaluate the effect of venom <I>H</I>. <I>lepturus</I> on hematological changes and renal failure. Results of this study will help us in quick diagnosis and treatment of scorpion stinging and decreasing the mortality. In total 119 patients were studied. Various blood parameters such as ...
S.J. Emam
The aim of this study was to evaluate the effect of venom &lt;I&gt;H&lt;/I&gt;. &lt;I&gt;lepturus&lt;/I&gt; on hematological changes and renal failure. Results of this study will help us in quick diagnosis and treatment of scorpion stinging and decreasing the mortality. In total 119 patients were studied. Various blood parameters such as ...
Karimi Mehran - - 2008
Chronic hypercoagulable state expressed clinically by thromboembolic events has been described in thalassemia. One of the affected organs is the brain where symptomatic and asymptomatic damage has been reported. The present report describes seven cases who presented with the signs of cerebrovascular accident (CVA), five ischemic and two with hemorrhage. ...
Akar Najwa Ali - - 2008
OBJECTIVE: This study was designed to document the common causes and patterns of hospitalization among sickle cell disease (SCD) patients in Kuwait. SUBJECTS AND METHODS: The case files of all SCD patients admitted to the hospital between 1995 and 2004 were studied. Their personal data, hemoglobin genotype, diagnosis on admission, ...
Gulbis Béatrice - - 2008
An estimation of the incidence and demographic picture of the major hemoglobinopathies in Belgium has been approached through a confidential inquiry sent to 228 pediatric and adult hematological departments. Forty-two percent of responses showed that 417 patients are known in Belgium: 83% with sickle cell disease, 13% with beta-thalassemia (beta-thal) ...
Grey D E - - 2008
BACKGROUND AND OBJECTIVES: The role of red cell transfusion in the management of iron-deficiency anaemia is controversial. This audit was undertaken to monitor the overall transfusion practices of patients admitted to a 600-bed acute tertiary hospital with confirmed severe iron deficiency. MATERIALS AND METHODS: Data from 615 consecutive patients with ...
Provan Drew - - 2007
We conducted a retrospective analysis of 11 consecutive patients with various autoimmune cytopenias who failed to respond to conventional treatments and received a fixed-dose regimen of rituximab (100 mg weekly for 4 consecutive weeks). Sustained complete responses were achieved in 4 out of 7 patients with idiopathic thrombocytopenic purpura and ...
Inati A - - 2007
Sickle cell disease (SCD), the commonest single gene disorder worldwide, is an inherited disease that has different clinical and hematological manifestations in different populations. The objective of this study is to describe the characteristics of the Lebanese SCD population. This was a retrospective study that included information on 387 patients ...
Masera Nicoletta - - 2007
We performed an 11 year retrospective study on 34 sickle-cell paediatric patients, focusing on efficacy, safety and costs of an exchange transfusion program in 13 high risk patients. A good clinical control with improvement in patients' quality of life, no disease related complications, no significant iron overload and no procedure ...
Rao Sunil V - - 2008
The purpose of this study was to determine international patterns of blood transfusion in patients with acute coronary syndrome (ACS). Previous studies showed geographic heterogeneity in some aspects of ACS care. Data for variability in the use of blood transfusion in ACS management are limited. Pooled data from 3 international ...
Aessopos Athanassios - - 2008
OBJECTIVES: Intervertebral disc calcification, an age-related phenomenon of variable clinical significance is described in hemochromatosis. As beta-thalassemia is characterized by excessive tissue iron deposition and secondary hemosiderosis, and skeletal abnormalities are often observed in these patients, this study is conducted to identify the prevalence of Intervertebral Disc Calcification (IDC) in ...
Vitale Michael G - - 2007
STUDY DESIGN: This is a retrospective cohort study examining 61 patients with neurogenic scoliosis who underwent anterior and/or posterior spinal instrumentation at the age of 18 and younger. OBJECTIVE: The purpose of this study is to investigate this finding further by analyzing the effect of recombinant human erythropoietin (rhEPO) on ...
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