Search Results
Results 401 - 450 of 14605
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Tan Wei Sheng WS National Skin Centre, Singapore, - - 2014
Background/Aims: Prurigo nodularis (PN) has multiple reported disease associations, and this study analyzes the demographics, clinical distribution and underlying etiologies in an Asian cohort. Methods: A 1-year retrospective study was carried out on PN patients with extensive lesions (≥10) who attended a specialized itch clinic. Results: 37 patients (46% male, ...
Niv Eva E IBD Center, The Department of Gastroenterology and Liver Diseases, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel(1). Electronic address: - - 2014
The aim of this study was to perform sequential small bowel (SB) capsule endoscopy (CE) studies in patients with known active Crohn's disease (CD) during different treatments, to characterize the changes in the SB mucosa over time, and to correlate the CE findings with clinical and laboratory parameters of inflammation. ...
de Bruyn Jessica R JR Dept. of Gastroenterology and Hepatology, Academic Medical Center (AMC) Amsterdam, The - - 2014
Vitamin D deficiency has been observed in a wide range of medical conditions including Crohn's disease (CD). We aimed to assess whether CD patients have lower vitamin D levels than healthy controls, and to determine risk factors for vitamin D deficiency. 25(OH)D was measured by chemiluminescent immunoassay in serum obtained ...
Gothe F F Dr. von Hauner Children's Hospital, Division of Gastroenterology and Hepatology, Ludwig-Maximilians-University, Munich, - - 2014
Measurement of 7 alpha-hydroxy-4-cholesten-3-one (C4) in serum is a semiquantitative test for bile acid malabsorption (BAM). We have previously established pediatric normal values for C4 with an upper limit of normal of 66.5ng/mL, independent of age and sex. Here we performed the C4 test in 58 pediatric patients with Crohn's ...
Attia Dina D Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Department of Gastroenterology, Hepatology and Endemic Medicine, Beni Suef University, Beni Suef, - - 2014
Acoustic radiation force impulse imaging is used to assess stages of liver fibrosis. The aim of our study was to evaluate liver stiffness changes in patients with biliary obstruction with or without sclerosing cholangitis after biliary drainage. A total of 71 patients were enrolled in this prospective study (cohort N=51, ...
Bank Anna M AM Department of Neurology, Columbia University Medical Center, 710 W. 168th Street, 7th Floor, New York, NY 10032, USA. Electronic address: - - 2014
Extraoperative electrocortical stimulation mapping (ESM) is used to identify functional cortex prior to epilepsy surgery, with the goal of preserving function postoperatively. Although attempts are made to avoid stimulation-evoked seizure activity, the clinical impact of these events with regard to safety, clinical utility, functional outcome, and even disruption to the ...
Kalousová Marta M Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University in Prague, Prague, Czech Republic. Electronic address: - - 2014
PAPP-A is an independent mortality predictor of long term hemodialysis patients and a prognostic marker of acute coronary syndrome in general population. Cys327Cys PAPP-A polymorphism(SNP) (rs12375498) was found to be of significance in preeclampsia and the C allele of the PAPP-A C/G SNP (rs13290387) was defined as an independent risk ...
Miyasato Mai M Department of Internal Medicine (I), Osaka Medical College, Osaka, - - 2014
The serum cytokeratin-18 fragment (CK-18) concentration has been suggested to be a biomarker of nonalcoholic fatty liver disease (NAFLD), although its usefulness in patients with type 2 diabetes mellitus (T2DM) is unknown. The study was divided into two parts. In the first cross-sectional study, a total of 200 patients with ...
Yahaba Misuzu M Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. Electronic address: - - 2014
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and small airway narrowing. Quantitative evaluation of airway dimensions by multi-detector computed tomography (MDCT) has revealed a correlation between airway dimension and airflow limitation. However, the effect of emphysema on this correlation is unclear. The goal of ...
Mohseni Fariba F Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, - - 2014
Low BMDs, short stature, hypogonadism, subclinical hypothyroidism, and IFG are found in 3.3, 10, 33, 16.6, 6.6, and 26.6 % of 30 pediatric β thalassemia major patients, respectively. Age is related with low Z-scores. Short stature and hypogonadism patients were older. These patients' monitoring in late childhood and early teenage for ...
Nichols-Vinueza Diana X DX Division of Hematology/Oncology, Harvard Medical School, Boston, MA; Boston Children';s Hospital, Harvard Medical School, Boston, - - 2014
Background: Oral iron chelators and MRI assessment of heart and liver iron burden have become widely available since the mid 2000s, allowing for improved patient compliance with chelation and noninvasive monitoring of iron levels for titration of therapy. We evaluated the impact of these changes in our center for patients ...
Fortún J J Infectious Diseases Department, Ramon y Cajal Hospital, Ctra Colmenar km 9.1, 28034, Madrid, Spain, - - 2014
Studies on biomarkers in tuberculosis are focused on pulmonary forms of this disease (PTB), and only limited information is currently available on biomarkers of extra-pulmonary tuberculosis (EPTB). Serum samples from 24 patients with PTB, 29 patients with EPTB and 27 healthy controls were obtained, and the levels of interferon-gamma, chemokine ...
Mikolasevic Ivana I Department of Nephrology and Dialysis, University Hospital Center Rijeka, Rijeka, Croatia, - - 2014
The relationship between nonalcoholic fatty liver disease (NAFLD) and coronary heart disease (CHD) is poorly understood. In the present study, we aimed to assess the frequency of NAFLD in CHD patients by using a new diagnostic tool: transient elastography (TE; Fibroscan(®)-CAP). Clarification of the present study may help to provide ...
Kanazawa Hidenori H Departments of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan, - - 2014
The purpose of this study was to compare the degree of colorectal distention between manual insufflation using room air and automatic insufflation using carbon dioxide for computed tomography colonography performed as a preoperative examination for patients with colon cancer. Participants comprised 200 patients who underwent computed tomography colonography immediately after ...
Jung M M University of Western Ontario, Schulich School of Medicine and Dentistry, Department of Medicine, Division of Rheumatology, St Joseph's Health Care , London, ON , - - 2014
Objective: To determine the clinical impact of muscle involvement in a large systemic sclerosis (SSc) cohort. Method: Using the Canadian Scleroderma Research Group (CSRG) database, SSc patients with either elevated creatine kinase (CK) or a prior history of myositis/myopathy were identified. Regression and Kaplan-Meier analyses were performed to determine characteristics ...
Resorlu Hatice H Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, - - 2014
The purpose of our study was to measure epicardial adipose tissue (EAT) thickness as a novel indicator of atherosclerosis and cardiovascular risk factor in ankylosing spondylitis (AS) patients and to show the relationship with clinical parameters and inflammatory markers. Forty AS patients (42.75 ± 12.43 years) and 40 healthy individuals with no cardiovascular ...
Abdulkadyrov Kudrat M KM Russian Research Institute of Haematology and Blood Transfusion, St Petersburg, - - 2014
This phase IIa study evaluated the safety and tolerability of sotatercept, and its effects on bone metabolism and haematopoiesis in newly diagnosed and relapsed multiple myeloma (MM) patients. Patients were randomized (4:1) to receive four 28-d cycles of sotatercept (0·1, 0·3, or 0·5 mg/kg) or placebo. Patients also received six cycles ...
Kakugawa Tomoyuki - - 2014
Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. We hypothesized that HSP47 could be a useful marker for fibrotic lung disease. The aim of this study was to evaluate serum levels of HSP47 in patients with various idiopathic interstitial pneumonias ...
Valenti Luca L Luca Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni, Serena Rovida, Raffaela Rametta, Erika Fatta, Edoardo Alessandro Pulixi, Silvia Fargion, Department of Pathophysiology and Transplantation, Metabolic Liver Diseases Research Center, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Policlinico, via F Sforza 35, 20122, Milano, - - 2014
To compare iron depletion to lifestyle changes alone in patients with severe nonalcoholic fatty liver disease (NAFLD) and hyperferritinemia, a frequent feature associated with more severe liver damage, despite at least 6 mo of lifestyle changes. Eligible subjects had to be 18-75 years old who underwent liver biopsy for ultrasonographically ...
Lin Yu-Sheng - - 2014
The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in adult congenital heart disease (ConHD) patients in Taiwan. From the National Health Insurance Research Database (1997-2010), adult patients (>=18 years) with ConHD were identified and compared to non-ConHD control patients. The primary end ...
Lim Yun Jeong YJ Yun Jeong Lim, Department of Internal Medicine, College of Medicine, Dongguk University, Gyeonggi-Do 410-773, South - - 2014
Adequate bowel preparation is important for successful colonoscopic examination. Several effective colonic cleansing agents are available and routinely prescribed, but each carries its own limitations and benefits from particular dosing regimens. The most frequently prescribed colonic cleansing agent, the polyethylene glycol (PEG) cathartic solution, suffers from low patient compliance in ...
Saha Soma - - 2014
Some of the patients with idiopathic hypoparathyroidism (IHP) report symptoms of hypocalcemia during menstruation. There is limited data on this observation. Twenty six menstruating women with IHP and 26 healthy controls were questioned regarding symptoms suggestive of hypocalcemia during menstruation. Twelve patients and eight controls were asked to prospectively monitor ...
Brophy Robert H RH Sports Medicine Service, Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, - - 2014
BACKGROUND:Patient activity level may be an important prognostic variable relating to outcomes in patients with shoulder disorders. Little is known about the predictors of activity level in patients with shoulder disorders. HYPOTHESIS:Tear size and patient variables would be predictive of shoulder activity level in a cohort of patients who have ...
Aksu Cerman A A Şişli Etfal Training and Research Hospital, Dermatology - - 2014
Alopecia areata is a T-cell mediated autoimmune disease that causes inflammation around anagen-stage hair follicles. Deficient vitamin D levels have been implicated in patients with a variety of autoimmune diseases in recent years. Previous reports have described the effects of vitamin D on hair follicles. The aim of the study ...
Hirohata Shunsei - - 2014
Although neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the recalcitrant complications of the disease, its pathogenesis still remains unclear. Previous studies revealed that antibodies reactive with NMDA (N-methyl-D-aspartate) receptor NR2 (anti-NR2) are elevated in cerebrospinal fluid (CSF) of patients with diffuse psychiatric/neuropsychological syndromes (diffuse NPSLE), which is usually more ...
Tachi Yoshihiko Y Department of Gastroenterology, Komaki City Hospital, Komaki, Aichi, - - 2014
Hepatocellular carcinoma develops even in some patients who achieve a sustained virological following treatment for hepatitis C virus infection. This study investigated the relationship between changes in fibrosis, as assessed by sequential biopsies, and development of hepatocellular carcinoma in patients who achieved a sustained virological response for hepatitis C virus. ...
Jürgens Tim P TP From the Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, - - 2014
The aim of the study was to determine whether various transient sensory and neuropsychological symptoms (SNS) were associated with migraine using a custom questionnaire. In this hypothesis-generating case-control study, the frequencies of transient SNS in 219 patients with migraine (149 without aura and 70 with aura) were compared with 161 ...
Ruiz-Limon Patricia P Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/Reina Sofia University Hospital/University of Cordoba, Cordoba, - - 2014
Statins may have beneficial vascular effects in systemic lupus erythematosus (SLE) beyond their cholesterol-lowering action, although the mechanisms involved are not completely understood. We investigated potential mechanisms involved in the efficacy of fluvastatin in preventing atherothrombosis in SLE. Eighty-five patients with SLE and 62 healthy donors were included in the ...
Ziegler Ingrid - - 2014
The commercial test, SeptiFast, is designed to detect DNA from bacterial and fungal pathogens in whole blood. The method has been found to be specific with a high rule-in value for the early detection of septic patients. In the case of positive results, the software automatically provides information about the ...
Lepoutre-Lussey Charlotte C C Lepoutre-Lussey, Department of Nuclear Medicine, Pitie-Salpetriere Hospital, Paris, - - 2014
ObjectiveCervical ultrasound (US) scan is a key tool for detecting metastatic lymph nodes (N1) in patients with papillary thyroid cancer (PTC). N1-PTC patients are stratified as intermediate and high risk patients, according to the American (ATA) and European (ETA) Thyroid Association respectively. The aim of this study is to assess ...
Rea Delphine D - - 2014
Despite a well-recognized clinical benefit of the 2nd generation tyrosine kinase inhibitor nilotinib in patients with imatinib-resistant/-intolerant or newly diagnosed chronic myeloid leukemia, recent evidence suggests that nilotinib has a propensity to increase the risk of occlusive arterial events, especially in patients with pre-existing cardiovascular risk factors. Given the key ...
Cotrena Charles C Department of Psychology, Pontifical Catholic University of Rio Grande do Sul , Porto Alegre, Rio Grande do Sul , - - 2014
Abstract Summary: The aim of the present study was to use the Iowa Gambling Task (IGT) to investigate differences in decision-making (DM) between patients who sustained TBI and healthy subjects, while controlling for age, education and gender. Methods: A hundred and ten participants, half of whom had severe or mild ...
Brembilla-Perrot Béatrice B Department of Cardiology, Nancy University Hospital, Vandoeuvre-les-Nancy, - - 2014
Atrial fibrillation (AF) and flutter (AFL) are frequently associated. We assessed the frequency and identify the predictors of AF occurrence after AFL ablation. 1121 patients referred for AFL ablation were followed for a mean duration of 2.1±2.7 years. Antiarrhythmic drugs were stopped after ablation in patients with no AF prior ...
Järventausta Petri J PJ Helsinki University Eye Hospital, Helsinki, - - 2014
To refine the diagnostic criteria for peripheral hypertrophic subepithelial corneal degeneration (PHSD) and characterize its clinical phenotype, histopathology and immunohistochemical features. Diagnostic criteria were refined on the basis of literature data. Fourteen patients (13 women and one man; median age 52 years, range 33-66) were identified based on these criteria. Keratectomy ...
Liu Janet C JC 1 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0719, La Jolla, CA 92093-0719, - - 2014
Naltrexone is effective in treating opioid dependence by blocking µ, κ and δ opiate receptors. Naltrexone is mainly metabolized to an active metabolite 6β-naltrexol by dihydrodiol dehydrogenase enzymes. Concomitant opioids will not be effective while patients are taking this antagonist. This was a retrospective analysis of urinary excretion data collected ...
Feng S S Department of Otolaryngology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, - - 2014
Allergic rhinitis (AR), non-allergic rhinitis (NAR), chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic rhinosinusitis without nasal polyps (CRSsNP) occur frequently in asthmatic patients. We evaluated nasal symptoms and nasal endoscopic findings in patients with asthma and correlated them to asthma severity. Subjects (n=150) with asthma completed questionnaires designed to ...
Jois Bhargavi B From the Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Bombay, - - 2014
The aim of the study was to evaluate somatostatin receptor expression in non-I-concentrating metastatic differentiated thyroid carcinoma by Ga-DOTATATE PET-CT/Tc-HYNIC-TOC scintigraphy and to determine the feasibility of Lu-DOTATATE (therapeutic analog) therapy in cases with positive Ga-DOTATATE PET-CT/Tc-HYNIC-TOC scintigraphy. In this research study, 19 patients diagnosed with differentiated thyroid carcinoma with ...
Cippà Pietro E PE Division of Internal Medicine, University Hospital Zurich, - - 2014
Iron status evaluation in patients with suspected liver disease and elevated serum ferritin is often challenging, since hyperferritinemia does not always indicate iron overload. A reliable approach to estimate iron overload without exposing the patient to unnecessary investigations would help the clinician to identify patients who may take advantage from ...
Suh Dong-Hun DH Department of Orthopedics, Korea University Ansan Hospital, Ansan, South - - 2014
of Context: Knowledge of sagittal spino-pelvic parameters and hip dysplasia is important in cerebral palsy patients because these parameters differ from those found in the general population and can be related to symptoms. The purpose of this study was to analyze sagittal spino-pelvic alignment and determine its relation to hip ...
Bernstein Jonathan A JA University of Cincinnati Medical Center, Cincinnati, Ohio. Electronic address: - - 2014
Despite the worldwide obesity epidemic, there have been very few studies investigating the influence of body weight on treatment dosing and outcomes in patients with hereditary angioedema (HAE). The purpose of this analysis was to determine whether the standard weight-based dosing recommendation of C1 esterase inhibitor (C1-INH) concentrate (20 IU/kg) ...
Park Soo-Kyung SK Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of - - 2014
Although some ulcerative colitis (UC) patients are diagnosed when they do not have any UC-related symptoms, clinical features and prognosis of UC diagnosed in asymptomatic patients remain unclear. Data for UC patients who were asymptomatic at diagnosis were retrospectively reviewed from the IBD database of the Asan Medical Center. The ...
Kinugawa Koichiro K Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of - - 2014
Background: Loop diuretics are commonly used in heart failure (HF) patients, but they are sometimes associated with insufficient response as well as adverse events. In such diuretics-resistant cases, tolvaptan, a vasopressin type 2 receptor antagonist, shows the improvement of volume overload without electrolyte imbalance. Tolvaptan was launched in Japan in 2010, ...
Cardenas Jessica C JC 1Department of Surgery and 2The Center for Translational Injury Research The University of Texas Health Science Center at - - 2014
Severe hyperfibrinolysis following trauma is a poorly understood phenomenon associated with profound shock, serious anatomic injuries, increased transfusions and high mortality rates. Molecular mechanisms driving hyperfibrinolysis in trauma have not been completely delineated. To determine the relationship between severe hyperfibrinolysis and outcomes in trauma patients and characterize the role of ...
Tokioka Koji K Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, - - 2014
This study aimed to determine the usefulness of the combination of several electrocardiographic (ECG) markers on risk assessment of ventricular fibrillation (VF) in patients with Brugada syndrome (BrS). Detection of high/low-risk BrS patients using a noninvasive method is an important issue in the clinical setting. Several ECG markers related to ...
Greve Yvonne Y Department of Emergency and Critical Care Medicine, Nuremberg Hospital, Institute for Clinical Chemistry, Laboratory Medicine, and Transfusion Medicine, Nuremberg Hospital, Master Program M. Sc. Medical Process Management, Friedrich-Alexander-University Erlangen-Nürnberg, Department of Geriatrics, Nuremberg Hospital, Chairholder at the Department of Health Economics, Friedrich-Alexander-University Erlangen-Nürnberg, Departement of Internal Medicine, Universitätsspital Basel, - - 2014
The prognostic significance of near-syncope has not yet been adequately characterized. We collected prospective data on a consecutive series of patients seen in an emergency department with syncope (brief loss of consciousness, usually with loss of muscle tone) or near-syncope (a feeling that syncope is about to occur, but without ...
Sillanpää M M Departments of Public Health and Child Neurology, University of Turku, Turku, - - 2014
We present a case of neonatal eating epilepsy. Case report. An otherwise healthy female newborn started having epileptic seizures lasting up to 5minutes induced by breastfeeding at age of 2 weeks. The convulsive seizure started with crying and coughing followed by opisthotonus, flexion of upper extremities, extension of lower extremities, ...
Baykaner Tina T Department of Medicine, University of California, San Diego, CA, 92161, - - 2014
Atrial fibrillation (AF) is the most common sustained arrhythmia and the most common indication for catheter ablation. However, despite substantial technical advances in mapping and energy delivery, ablation outcomes remain suboptimal. A major limitation to AF ablation is that the areas targeted for ablation are rarely of proven mechanistic importance, ...
Pan Gaofeng G Department of Thoracic and Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei, 430071, P. R. - - 2014
The systematic review and meta-analysis are to evaluate the effect of telmisartan on atrial fibrillation (AF) recurrences in hypertensive patients with paroxysmal AF. Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched. Random controlled trials (RCTs) were conducted in which telmisartan was compared to other antihypertensive drugs ...
Lankisch Tim O TO Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Integrated Research and Treatment Center - Transplantation (IFB-Tx), Hannover Medical School, Hannover, - - 2014
Background: Biliary complications after liver transplantation remain a major cause of morbidity and reduced graft survival. Ischemic type biliary lesions (ITBL) are common and difficult to treat. The pathophysiology of ITBL remains unclear and diagnostic markers are still missing. Analysis of microRNA (miRNA) profiles is an evolving field in hepatology. ...
Abourazzak Fatima Ezzahra FE Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco, - - 2014
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular disease (CVD). The prevalence of metabolic syndrome (MetS)-a major contributor to CVD-in RA seems to be increased, suggesting that systemic inflammation and antirheumatic therapy may contribute to its presence. We aimed to determine the prevalence of MetS in RA, ...
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