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Results 351 - 400 of 17709
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Barbosa Izabela G IG Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Universidade Federal de Minas Gerais (UFMJ), Belo Horizonte, MG, - - 2014
Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD). Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by ...
Matesan Manuela M Departments of aRadiology bMedicine, Division of Medical Oncology, University of Washington Medical Center cClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington dDepartment of Radiology, Harvard Medical School, MGH Hospital, Boston, Massachusetts, - - 2014
Biodistribution data to date using In-ibritumomab tiuxetan have been initially obtained in patients with less than 25% lymphomatous bone marrow involvement and adequate hematopoietic synthetic function. In this article we present the results of an analysis of the biodistribution data obtained from a cohort of patients with extensive bone marrow ...
Zhu Lixin L State University of New York at Buffalo - - 2014
Previous studies using culture based methods suggested an association between constipation and altered abundance of certain taxa of the colonic microbiome. We aim to examine the global changes in gut microbial composition of constipated patients. A cross-sectional pilot study was performed to compare stool microbial composition of 8 constipated patients ...
Carruthers Katherine H KH Ms Carruthers is a medical student at The University of Toledo College of Medicine in Toledo, OhioDr Kocak is a plastic surgeon in private practice in Dublin, OhioDr Hulsen is a clinical house staff member in the Department of Plastic Surgery at The Ohio State University in Columbus, OhioDr McMahan is a plastic surgeon in private practice in Columbus, - - 2014
Abdominoplasty is indicated in cosmetic surgery to improve body contour. Results from several studies suggest that abdominoplasty also could be therapeutic for certain individuals with urinary incontinence. The authors sought to determine the potential therapeutic effect of abdominoplasty on urinary incontinence in a large population to confirm the findings of ...
Bonnefoy-Mazure A A Willy Taillard Laboratory of Kinesiology, Geneva University Hospitals and Geneva University, Switzerland. Electronic address: - - 2014
Patients with cerebral palsy (CP) are characterized by a large diversity of gait deviations; thus, lower limb movements during gait have been well-analyzed in the literature. However, the question of upper limb movements and, more particularly, arm movements during gait has received less attention for CP patients as a function ...
Malhotra Reenu R Miraca Life Sciences Research Institute, Irving, - - 2014
It is unclear whether the reported low prevalence of inflammatory bowel disease (IBD) in Southern and Eastern Asia is real (caused by genetic or environmental factors) or spurious (due to differences in awareness of the condition among physicians or different interpretations of endoscopic and histological features). We aimed to estimate ...
Lee Cha Gon CG Department of Pediatrics, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Republic of - - 2014
Background: The first episode of central nervous system (CNS) symptoms with a presumed inflammatory demyelinating cause is defined as clinically isolated syndrome (CIS) according to the 2007 consensus of the International Pediatric Multiple Sclerosis Study Group, which developed diagnostic criteria for CNS demyelination disease in children. Using this definition of ...
Bazan Jose G JG Department of Radiation Oncology, Stanford University, Stanford, - - 2014
To identify a panel of radiation-responsive plasma proteins that could be used in a point-of-care biologic dosimeter to detect clinically significant levels of ionizing radiation exposure. Patients undergoing preparation for hematopoietic cell transplantation using radiation therapy (RT) with either total lymphoid irradiation or fractionated total body irradiation were eligible. Plasma ...
Ahmed Kamran A - - 2014
Prostate-specific antigen (PSA) nadir + 2 ng/mL, also known as the Phoenix definition, is the definition most commonly used to establish biochemical failure (BF) after external beam radiotherapy for prostate cancer management. The purpose of this study is to compare BF rates between permanent prostate brachytherapy (PPB) and radical retropubic ...
Rubino Alfonso A Department of Neurology and Psychiatry (Parkinson's Centre), University "Sapienza", Rome, - - 2014
Freezing of gait (FOG) is as a brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk. Structural neuroimaging studies on FOG in PD using volumetric techniques yielded variable and partially conflicting findings, probably reflecting the heterogeneity and complexity of the phenomenon. The ...
Cheng Hao-Yuan - - 2014
Enterovirus 71 (EV71) is a great disease burden across the whole world, particularly in Southeast Asia. However, in recent decades, the pathogenesis of severe EV71 infection was not well understood. This study was aimed to investigate the correlation between the presence of viremia and the clinical severity of EV71 infection. ...
Ochi Kensuke K Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University , Shinjuku, Tokyo , - - 2014
Objective. First objective is to validate the Disabilities of the Arm, Shoulder and Hand (DASH) and Quick DASH (QuickDASH) questionnaire in rheumatoid arthritis (RA) patients with functional upper extremity impairment. Next is to clarify which clinical factor is associating with QuickDASH using a large cohort of RA. Methods. The QuickDASH ...
Okamura Koichi K Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine , Maebashi, Gunma , - - 2014
Objective. Iguratimod (IGU) is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis (RA). We conducted a 24-week study on the efficacy of IGU in RA patients with daily clinical use. Methods. Forty-one patients were enrolled in this study, and the improvement in RA was evaluated ...
Gülhan Bora B Hacettepe University, Department of Pediatric Pulmonology, Ankara, - - 2014
Thalassemia major (TM) is characterized by abnormal hemoglobin synthesis which results in decreased oxygen delivery to the tissues, ineffective erythropoiesis, and iron overload. The purpose of this study was to find out the predominant type of lung mechanical abnormalities in TM patients, the prevalence of the change in pulmonary diffusing ...
Soliotis Fotini F Euroclinic Hospital, Athens, Greece. - - 2014
Given that the clinical features of several IgG4-related diseases (IgG4-RD) can mimic those of autoimmune disorders, the aim of this study was to find possible distinguishing characteristics that would help us identify such cases from the pool of patients in a rheumatology clinic. From our clinic's medical records, we identified ...
Perez Mariana O MO Division of Rheumatology, University of São Paulo, São Paulo, Brazil. - - 2014
Proton pump inhibitors (PPI) are widely used in patients with systemic sclerosis (SSc) due to the chronic gastroesophageal reflux. The authors report a female patient with a 9-year history of SSc and long-term use of omeprazole, who complained of paresthesia and asthenia for 12 months. Physical examination revealed clinical signs ...
Wolf Harald H Medical University of Vienna, Trauma Surgery , Waehringer Guertel 18-20 , Vienna, Vienna, Austria , A-1090 , +43-1-40400-5901 , Schellenhofgasse 18aVienna, Vienna, Austria , A-1230 ; - - 2014
The objective of this study was to determine whether the type of intracranial traumatic lesions, the number of simultaneous traumatic lesions, and the occurrence of skull and facial bone fractures have an influence on S100B serum levels. Patients with blunt traumatic brain injury were prospectively enrolled into this cohort study ...
Yong X X Department of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, Guangxi, - - 2014
Periodontal diseases are often induced by periodontopathogens, which are always exposed to certain innate immune factors in gingival crevicular fluid, including human β-defensin-2 (hBD-2). This study aims to investigate the relationship among periodontopathogens, clinical parameters and hBD-2 expression. Thirty-two healthy controls, 42 patients with chronic gingivitis and 95 patients with ...
Wu Teddy Y TY 1 Department of Neurology, Auckland City Hospital, 2 Park Road, Auckland 1023, New - - 2014
Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) is a recently recognized neurodegenerative ganglionopathy. Prompted by the presence of symptomatic postural hypotension in two patients with CANVAS, we hypothesized that autonomic dysfunction may be an associated feature of the syndrome. We assessed symptoms of autonomic dysfunction and performed autonomic nervous ...
Misciali Cosimo C Departments of *Specialised, Experimental and Diagnostic Medicine, Section of Dermatology, and †Vascular Surgery, University of Bologna, Bologna, - - 2014
: Vascular leg ulcers remain a challenge for the modern health care, and a systematic pathological study on this kind of lesions has not been reported so far. A total of 293 consecutive white patients with chronic leg ulcers (present for a minimum of 6 months and up to several ...
Zhang Long Jiang LJ From the Department of Medical Imaging (L.J.Z., Z.Z., C.S.Z., Y.E.Z., U.J.S., G.M.L.) and Research Institute of Nephrology (S.J.L.), Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, China 200012; and Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC (F.G.M., J.W.N., - - 2014
Purpose To prospectively determine the prevalence of pulmonary embolism (PE) and renal vein thrombosis (RVT) with computed tomography (CT) and to identify markers predictive of PE and/or RVT in a large consecutive cohort of patients with nephrotic syndrome. Materials and Methods This study was approved by the local institutional review ...
Francia Pietro P Division Cardiology, Department of Clinical and Molecular Medicine, St. Andrea Hospital, Sapienza University, Rome, - - 2014
Nonsustained ventricular tachycardia (NSVT) is a risk factor for sudden death (SD) in hypertrophic cardiomyopathy (HCM). Implantable cardioverter-defibrillators (ICDs) enable accurate assessment of NSVT burden and characteristics. In a cohort of HCM patients with ICD, we characterized Holter- and ICD-retrieved NSVT and evaluated their relationship with prognosis. We studied a ...
Moermans C C Department of Pneumology-Allergology, Avenue de l'hopital, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, - - 2014
Patients undergoing hematopoietic SCT (HSCT) display an airway neutrophilic inflammation before transplantation that persists over the years. In this study, we have investigated the cytokine profile over a period of 1 year in the sputum supernatant of patients who underwent HSCT. We have measured sputum supernatant levels of TNF-α, TGF-β1, ...
Isoyama Naohito N Divisions of Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden Department of Urology, Yamaguchi University, Ube, Yamaguchi, - - 2014
Alterations in the advanced glycation end-products (AGE)-receptor of AGE (RAGE) system are linked to several chronic diseases, which may result from vascular damage. A high circulating level of the pro-inflammatory RAGE-ligand S100A12, also known as EN-RAGE, is thought to promote while a high level of soluble RAGE (sRAGE) is thought ...
Pardaens Sofie S Department of Internal Medicine, Ghent University, Ghent, Belgium. Electronic address: - - 2014
The presence of ergoreflex activity and its current relation to hyperventilation and prognosis in cardiac patients is unclear. Therefore, we evaluated ergoreflex activity in cardiac patients with and without heart failure (CHF) as well as in healthy subjects, and we examined how strong ergoreceptor activity was related to a mortality ...
Lee Vivien H VH Department of Neurological Sciences, Section of Cerebrovascular Disease, Rush University Medical Center, Chicago, Illinois. Electronic address: - - 2014
A serious complication of intravenous tissue plasminogen activator (tPA) in acute ischemic stroke is hemorrhage. Coagulation factors that may potentially increase the risk of bleeding after tPA are not well understood. We retrospectively reviewed 284 acute ischemic stroke patients who received tPA. Post-tPA coagulopathy was defined as a documented elevation ...
Toshniwal Gokul G Department of Anesthesiology, Oakwood Health Care System, Dearborn, MI 48124, - - 2014
To determine if a high score (≥ 3) on the STOP-Bang screening questionnaire for obstructive sleep apnea (OSA) predicts whether obese patients are at high risk for OSA and increased risk of difficult airway. Prospective, questionnaire-based clinical assessment. University-affiliated hospital. 127 ASA physical status 2 and 3 patients, who were ...
Zorlu Nabi N Katip Celebi University Ataturk Training And Research Hospital, Department Of Psychiatry, Izmir, Turkey. Electronic address: - - 2014
A number of diffusion tensor imaging (DTI) studies have reported substantial white matter (WM) abnormalities in alcohol-dependent patients. These studies were usually performed in recovering alcohol-dependent patients who had been abstinent for days to several weeks. The current study was designed to examine WM microstructure and decision-making in a sample ...
Conte Carmela C Rehabilitation Centre, Movement Analysis LAB, Policlinico Italia, Rome, - - 2014
Although abnormal oscillations of the trunk are a common clinical feature in patients with cerebellar ataxia, the kinematic behaviour of the upper body in ataxic patients has yet to be investigated in quantitative studies. In this study, an optoelectronic motion analysis system was used to measure the ranges of motion ...
Kim Sei Won SW Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, South - - 2014
Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) to determine ...
Jung Yoon Suk YS Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyung-Dong, Jongro-Ku, Seoul, 110-746, - - 2014
Patients with Crohn's disease (CD) are frequently exposed to diagnostic radiation, mainly as a result of abdominopelvic computed tomography (APCT) examinations. However, there are limited data on the impact of APCT on clinical management in this population. To investigate clinical predictors of urgent findings on APCT in patients with CD ...
Flores-Contreras Lucia - - 2014
The aim of this study was to assess whether two-years treatment with Pirfenidone influences necroinflammation, fibrosis and steatosis, serum levels of TGF-beta1, IL-6, TNF-alpha and CB1 and CB2 gene expression, in patients with chronic hepatitis C (CHC). Twenty-eight patients out of 34 with CHC virus infection were enrolled in the ...
Pan Xi-Feng XF Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital, China Medical University, Beier Road No. 92, Shenyang, 110001, - - 2014
Thyroid autoimmunity is the most common organ-specific autoimmune disorder, which is characterized by the production of thyroid autoantibodies and lymphocytic infiltration into the thyroid. The majority cases of chronic urticaria have unknown (idiopathic) causes, with about 30-40 % possibly having an autoimmune substrate. Considering that autoimmune factors may be the common ...
Sorkhabi Rana R Tabriz University of Medical Sciences, Tabriz, Iran, - - 2014
To determine the concentration of inflammatory mediators in the tear film of patients with keratoconus. Basal tears from patients with keratoconus and from normal controls were collected using a capillary tube. Patients with keratoconus were examined in a routine fashion, and keratometric readings were also taken from corneal topographic maps ...
Namm Jukes P JP Department of Surgery, University of Chicago, Chicago, IL, - - 2014
When microinvasion cannot be ruled out on core needle biopsy (CNB) in the setting of ductal carcinoma in situ (DCIS), the surgeon must decide whether to perform a sentinel lymph node biopsy (SLNB) at the time of surgery. Up to 10 % of patients with T1mi have nodal disease, but the ...
Almalki Mussa H MH Obesity, Endocrine and Metabolism Center, King Fahad Medical City, Riyadh, Saudi Arabia, - - 2014
The management of giant prolactinomas remains a major challenge, despite dopamine agonists being the first line of treatment, owing to its efficacy to normalize prolactin levels and reduce tumor volume. The aim of this study is to characterize the therapeutic aspects, manifestations and outcomes of 16 cases of giant prolactinomas ...
Li Da-Wei DW Department of Neurology, Neurobiology and Geriatrics, National GCP Clinical Trial Center on Neurodegenerative Disease, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing, 100053, - - 2014
Non-motor symptoms (NMS) are common among patients with Parkinson's disease (PD). However, reports on NMS in Chinese PD population are scarce. Little is known about NMS in patients with Asian specific leucine-rich repeat kinase 2 (LRRK2) variants in G2385R and R1628P. This study aimed to elucidate the clinical characteristics of ...
Bruni Cosimo C Department of Clinical and Experimental Medicine, Section of Rheumatology, University of Florence, Florence, - - 2014
The aim of this study was to evaluate the presence of digital lesions in very early diagnosis of SSc (VEDOSS) patients and its possible association with internal organ involvement. One hundred and ten VEDOSS patients were investigated for the presence of digital ulcers (DUs), digital pitting scars, calcinosis, necrosis or ...
Brugière C C CHU Caen, Department of Dermatology, Caen, F-14000, France; Université Caen Basse-Nomandie, Medical School, Caen, F-14000, - - 2014
vemurafenib, an anti-BRAF molecule, improves survival among patients with metastatic BRAF mutated melanoma. Photosensitivity, a frequent cutaneous adverse effect induced by vemurafenib, can lead to cessation of treatment. we address the question of photosensitivity mechanisms in patients treated with vemurafenib for metastatic melanoma. in a prospective study including 12 patients, ...
Sezik Savaş S Department of Emergency Medicine, Tepecik Training and Research Hospital, Izmir, - - 2014
There are few studies researching the effect of fresh frozen plasma (FFP) transfusion on international normalized ratio (INR) in patients with coagulation abnormality. This study's aim was to determine the effect of FFP transfusion on INR as calculated pretransfusion. In addition, patients were grouped according to pretransfusion INR to determine ...
Chellamuthu Santhi S Santhi Chellamuthu, Steven M Thomas, Catherine Hill, Peter W G Brown, Department of Radiology, Sheffield Teaching Hospitals NHS trust, Northern General Hospital, Sheffield S5 7AU, United - - 2014
To evaluate the referrals with suspected arrhythmogenic right ventricular cardiomyopathy (ARVC) and compare cardiac MR (cMR) findings against clinical diagnosis. A retrospective analysis of 114 (age range 16 to 83, males 55% and females 45%) patients referred for cMR with a suspected diagnosis of ARVC between May 2006 and February ...
Elf Kristin K Institute of Neuroscience, Department of Clinical Neurophysiology, Uppsala University, Uppsala, - - 2014
T cells are important in the immunopathology of immune-mediated peripheral neuropathies (PNP) and activated vitamin D regulates the immune response through increasing the amount of regulatory T cells. An association between vitamin D deficiency and polyneuropathy has been stipulated; hence we assessed whether patients with primary immune-mediated PNP have low ...
Rubino Sebastian S Geisel School of Medicine at Dartmouth, Hanover; - - 2014
Object Many neurosurgeons obtain repeat head CT at the first clinic follow-up visit for nonoperative cerebral contusion and traumatic subarachnoid hemorrhage (tSAH). The authors undertook a single-center, retrospective study to determine whether outpatient CT altered clinical decision-making. Methods The authors evaluated 173 consecutive adult patients admitted to their institution from ...
Zengin Mehmet Ozgur MO Department of Ophtalmology, Izmir University Faculty of Medicine, Gursel Aksel Bulvarı, No. 14, Uckuyular, 35350, Izmir, Turkey, - - 2014
To evaluate the choroidal thickness using spectral-domain optical coherence tomography (OCT) in patients with pseudoexfoliation syndrome (PXS) and to compare them with healthy controls. This observational comparative study consisted of 35 PXS patients and 35 age- and sex-matched control cases. The control cases had neither systemic nor ocular disease. All ...
Pimienta Allen L AL Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, - - 2014
The presence of cardiovascular abnormalities in patients with spontaneous cerebrospinal fluid (CSF) leaks are not well-documented in the literature, as cardiovascular evaluation is not generally pursued if a patient does not exhibit additional clinical features suggesting an inherited connective tissue disorder. We aimed to assess this association, enrolling a consecutive ...
Pastor Andrés García AG Stroke Unit, Neurology Department, Hospital General Universitario Gregorio Marañón, Madrid, - - 2014
Vascular imaging is increasingly used for diagnosis of arterial occlusions in acute ischemic stroke (AIS) patients. Our aim was to determine whether computed tomography angiography (CTA) and Doppler/duplex ultrasound (DUS) before intravenous thrombolysis (IVT) is associated with a delay in time-to-treatment. Observational analysis of a prospective cohort of AIS patients ...
Ding Liang L Central Laboratory of Stomatology, Hospital of Stomatology, and the State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, 210093, People's Republic of - - 2014
Monocyte chemotactic protein-1 (MCP-1/CCL2) and macrophage inflammatory protein-1α (MIP-1α/CCL3) are small chemotactic proteins that have been found in several kinds of tumor tissue samples and function as key regulators of cancer progression. However, the expression of CCL2 and CCL3 in serum samples of oral squamous cell carcinoma (OSCC) patients remains ...
Freyvogel Mary M Breast Services, Cleveland Clinic Foundation, Cleveland, USA, - - 2014
Currently, no standard guidelines exist regarding routine screening imaging in breast cancer patients following autologous reconstruction. Concern over nonpalpable chest wall recurrence has prompted many to pursue screening imaging. We analyzed the pattern of locoregional recurrence (LRR) and yield of screening imaging and exam in these patients. We performed a ...
Liu Zhenyin Z Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, - - 2014
The aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Twenty TLE patients and 22 age- and gender-matched normal controls were included in this study. Voxel-wise analyses of ...
Applewhite Megan K MK Department of General Surgery, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA; Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin, - - 2014
The biochemical profile of classic primary hyperparathyroidism (pHPT) consists of both elevated calcium and parathyroid hormone levels. The standard of care is parathyroidectomy unless prohibited by medical comorbidities. Because more patients are undergoing routine bone density evaluation and neck imaging studies for other purposes, there is a subset of people ...
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