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Results 201 - 250 of 14605
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Richards Justin E JE From the Departments of Anesthesiology (J.E.R., A.K.M.), Orthopaedic Surgery (J.H., A.A.J., H.R.M., J.M.E., A.M.P., W.T.O., M.K.S.), and Division of Trauma and Surgical Critical Care (K.M.), Vanderbilt University Medical Center, Nashville, - - 2014
Hyperglycemia in nondiabetic patients outside the intensive care unit is not well defined. We evaluated the relationship of hyperglycemia and surgical site infection (SSI) in stable nondiabetic patients with orthopedic injuries. We conducted a prospective observational cohort study at a single academic Level 1 trauma center over 9 months (Level ...
Escobar Mauricio A MA Jr *Mary Bridge Children's Hospital and Health Center †MultiCare Institute for Research & Innovation, Tacoma, - - 2014
The purpose of the present study was to ascertain whether pediatric patients with chronic abdominal pain had concurrent fructose intolerance as determined by a standardized dose breath hydrogen test (BHT), and whether symptoms would improve with a low-fructose diet. The fructose BHT test was administered to patients evaluated in clinic ...
Rungan Santuri S Green Lane Pediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New - - 2014
To describe the indications and outcomes for pediatric patients and patients with congenital heart disease (CHD) undergoing heart transplantation (HT) in New Zealand. A retrospective audit of 253 patients who underwent HT from 1987 to end 2012 was undertaken. Thirty-seven patients were subdivided into two groups, those aged <18 years-pediatric ...
Kalita J J Department of Neurology, Sanjay Gandhi Post-Graduate Medical Sciences, Lucknow, - - 2014
A tertiary care teaching hospital in Lucknow, India. To evaluate the frequency and predictors of paradoxical tuberculoma in definite tuberculous meningitis (TBM) and its influence on TBM outcome. Demographic, clinical, biochemical, cerebrospinal fluid (CSF) findings, CD4 counts and magnetic resonance imaging (MRI) findings of 34 patients with definite TBM included ...
Sisman Gurhan G Division of Gastroenterology, Istanbul University Cerrahpasa Medical Faculty, Istanbul 34100, Turkey. - - 2014
Hypertriglyceridemia induces acute recurrent pancreatitis, but its role in the etiology of chronic pancreatitis (CP) is controversial. This study aimed to evaluate the clinical, laboratory and radiological findings of 7 patients with CP due to type 1 hyperlipidemia compared to CP patients with other or undefined etiological factors. We retrospectively ...
Huang Shang-Yi SY Department of Internal Medicine, National Taiwan University Hospital, B4:0509, No.7, Chung-Shan South Road, 10002, Taipei, R.O.C, Taiwan, - - 2014
Cereblon (CRBN) is essential for the anti-myeloma (MM) activity of immunomodulatory drugs (IMiDs), such as thalidomide and lenalidomide. However, the clinical implications of CRBN in MM patients are unclear. Using immunohistochemical (IHC) staining on paraffin-embedded bone marrow sections, the expression of CRBN protein in myeloma cells (MCs) was assessed in ...
Nozue Tsuyoshi - - 2014
Statin therapy results in regression and stabilization of coronary artery plaques, and reduces the incidence of coronary artery disease. However, statin therapy does not effectively halt the accumulation of necrotic core in all patients. The purpose of the present study was to identify the predictors associated with necrotic core progression ...
Mühlhausen Chris C Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany, - - 2014
Combined D,L-2-hydroxyglutaric aciduria (DL-2HGA; OMIM #615182) is a rare neurometabolic disorder clinically characterized by muscular hypotonia, severe neurodevelopmental dysfunction, and intractable seizures associated with respiratory distress. Biochemically, DL-2HGA patients excrete increased amounts of D- and L-2-hydroxyglutarate (D2HG and L2HG, respectively), with predominance of D2HG, and α-ketoglutarate, and show a decrease ...
Qi Xingshun X Xijing Hospital of Digestive Diseases, Fourth Military Medical University, No. 17 West Changle Road, Xi'an, 710032 - - 2014
Portal vein thrombosis (PVT) is a fairly common complication of liver cirrhosis. Importantly, occlusive PVT might influence the prognosis of patients with cirrhosis. Evidence from a randomized controlled trial has shown that anticoagulation can prevent the occurrence of PVT in patients with cirrhosis without prior PVT. Evidence from several case ...
Mouba J F JF Département de pédiatrie, faculté de médecine, université des sciences de la santé, Owendo, - - 2014
Objectives: To present the clinical aspects of leg ulcers among patients with sickle-cell disease, propose a protocol for treating them, and identify risk factors for their onset in our patients. Patients and methods: This 5-year retrospective descriptive study (2007-2012) includes six adolescents homozygous (SS) for this disease who had at ...
Ottosson Sandra S Department of Clinical Sciences, Otorhinolaryngology, Umeå University, 901 87, Umeå, Sweden, - - 2014
Persistent severe swallowing dysfunction with aspiration is a common and sometimes overlooked sequelae after treatment for squamous cell carcinoma of the head and neck (SCCHN) and may impact food intake and nutritional status. More knowledge is needed to increase the understanding of severe swallowing dysfunction as a risk factor for ...
Hendrikx Tijn - - 2014
Many patients report symptoms of palpitations or dizziness/presyncope. These patients are often referred for 24-hour Holter ECG, although the sensitivity for detecting relevant arrhythmias is comparatively low. Intermittent short ECG recording over a longer time period might be a convenient and more sensitive alternative. The objective of this study is ...
Swiątkowska-Stodulska R R Department of Endocrinology and Internal Medicine, Medical University of Gdańsk, Gdańsk, - - 2014
Glucocorticoids are a group of hormones with a particularly significant effect on hemostasis. In hypercortisolemic patients increased concentrations of II, VIII, and von Willebrand factors were reported. Considerably fewer studies were concerned with factor XII (FXII). There are reports of decreased FXII concentrations in both venous and arterial thrombosis patients. ...
Macías-Rodríguez Ricardo Ulises RU Liver Clinic, Department of - - 2014
Factors other than elevated levels of ammonia may be implicated in hepatic encephalopathy (HE) pathophysiology, including abnormal cerebral hemodynamics. Transcranial Doppler ultrasonography (TCD) evaluates cerebrovascular structural integrity and reactivity, through pulsatility index (PI) and breath-holding index (BHI), respectively. Aim: to evaluate cerebral hemodynamics by TCD in patients with compensated and ...
Davids Taryn T Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, - - 2014
The objectives were to determine the prevalence of laryngeal dysplasia and associated human papilloma virus (HPV) subtypes in adult patients, 18 years or older, suffering from laryngeal papillomatosis at a tertiary care institution. Retrospective cohort study. Patients with biopsy proven laryngeal papillomatosis were identified via chart review. All available pathology ...
Wang I-K IK Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan; Department of Internal Medicine, China Medical University College of Medicine, Taichung, Taiwan; Division of Nephrology, China Medical University Hospital, Taichung, - - 2014
Hemodialysis (HD) may increase the risk of acute subdural hematoma (SDH) with high fatality, but the extent of this disease in non-western populations is unclear. The incidence of and fatality from SDH in patients with end-stage renal disease (ESRD) on HD were examined for an Asian population. A cohort of ...
Cui F F Department of Neurology, Chinese PLA General Hospital, Beijing, - - 2014
The epidemiology, diagnosis, and treatment of motor neuron disease (MND) in Chinese patients are ill known. A registered study of 461 MND patients was conducted across 10 facilities in 7 Chinese cities from February 2009 to March 2010. Patients were classified as amyotrophic lateral sclerosis (ALS) (84.4%), progressive bulbar palsy ...
Klein-Wieringa Inge R IR From the Department of Rheumatology, and the Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the - - 2014
To investigate whether high molecular weight adiponectin (hmwAPN) mediates the associations of total adiponectin (totAPN) with radiographic progression in rheumatoid arthritis (RA) and hand osteoarthritis (HOA). Associations between baseline hmwAPN or totAPN levels with radiographic progression were determined using multivariate linear regression or generalized estimated equations. In patients with RA, ...
Panayi Vasilis V aPeninsula College of Medicine and Dentistry, Universities of Exeter and Plymouth bCornwall Gastrointestinal Unit cResearch and Development dHistopathology, Royal Cornwall Hospital eEuropean Centre for the Environment and Human Health, University of Exeter Medical School, Truro, - - 2014
Forty percent of patients with autoimmune hepatitis (AIH) present with acute jaundice/hepatitis. Such patients, when treated promptly, are thought to have a good prognosis. The objective of this study was to describe the natural history of AIH in patients presenting with jaundice/hepatitis and to determine whether the diagnosis could have ...
Burke James F - - 2014
The diagnostic evaluation in a patient presenting with acute stroke has several purposes depending on the clinical circumstances. These include identifying stroke mimics, differentiating ischemic stroke from intracerebral hemorrhage in the acute setting, clarifying stroke localization, and determining the stroke mechanism to guide secondary prevention. The neurologist needs to be ...
Xu Ying-Yang YY Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, - - 2014
Upper airway edema (UAE) occurs infrequently in hereditary angioedema (HAE), but still results in significant morbidity and mortality. To assess patients with HAE and UAE to determine whether unique features exist that can predict the risk of UAE. Clinical, laboratory, and genetic data were compared between 43 patients with HAE ...
Adekanle Olusegun O Department of Medicine, Obafemi Awolowo University, Obafemi Awolowo University Teaching Hospitals, Ile-Ife, Osun State, - - 2014
Background: Patients with chronic liver disease (CLD) have been reported to have sexual dysfunction irrespective of etiology. There is little or no report from Nigeria on this disorder. This study looked at sexual dysfunction among male patients with CLD. Materials and Methods: Patients with chronic viral hepatitis B, liver cirrhosis ...
Pomares Christelle C Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Nice - Hôpital de l'Archet, Université de Nice-Sophia Antipolis, C3M, Inserm U1065, Nice, - - 2014
Abstract. A 38-year-old man, returned from Ivory Coast 2 months ago and presented with a 3-month history of pruritus exclusively on the scrotum. Itching was continuous during the day and no pruritus was described in his wife and son. Clinical examination of the genitals revealed several nodules on the scrotum, ...
Lim Tae Sung - - 2014
We investigated levels of the beta-amyloid 1-42 (Abeta42), total tau protein (T-tau) and tau phosphorylated at position threonine 181 (P-tau) in cerebrospinal fluid (CSF) of idiopathic normal pressure hydrocephalus (iNPH) patients and tried to find their clinical implications in the evaluation and treatment of iNPH. Twenty-five possible iNPH patients were ...
Huang Hai-Jun HJ Department of Infectious Disease, Zhejiang Provincial People's Hospital, Hangzhou, Zheijiang 310014, P.R. - - 2014
The aim of the present study was to compare the clinical characteristics of tuberculous peritonitis (TBP) and spontaneous bacterial peritonitis (SBP) in patients with cirrhosis. A retrospective, matched case-control study was conducted consisting of 12 patients with cirrhosis diagnosed with TBP between 2008 and 2011. Control subjects were patients with ...
Chen Mingyi M Department of Hepatobiliary Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. - - 2014
Diagnosis of sepsis in critically ill patients is important to reduce morbidity and mortality. The present study was conducted to determine the role of serum leptin in the early diagnosis of sepsis and to establish a diagnostic model for sepsis. A retrospective study was conducted of 331 patients from an ...
Kiu Weber Chek Ing CI Cardiovascular and Metabolism Disease Therapeutic Area , F. Hoffmann-La Roche Ltd , Basel , - - 2014
The contribution of pro-inflammatory markers to cardiovascular (CV) risk and vascular calcification in chronic kidney disease (CKD) remains largely to be elucidated. We investigated the association between plasma levels of several biomarkers and calcification volume in three different vascular beds in CKD Stages 3 and 4 patients. This is a ...
Ji Qiaoying Q Department of Respiratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, P.R. - - 2014
Clinical history and physical examination are helpful in indicating the potential causes of pleural effusions (PEs). However, the accurate diagnosis and establishment of the causes of PE is an ongoing challenge in daily clinical practice. The primary aim of this study was to distinguish between infectious PE and malignant PE ...
Usami Eiseki E Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, - - 2014
Patients prescribed liposomal-amphotericin B (L-AMB) frequently require supplemental potassium to prevent hypokalemia. The aim of this retrospective study was to examine the appropriate potassium supplementation conditions to treat hypokalemia induced by L-AMB. The subjects were 100 hematological patients who received L-AMB for the first time between April 2012 and March ...
Leite da Silveira P P Department of Otolaryngology and Head and Neck Surgery, Universidade Estadual de Campinas (Unicamp, State University at Campinas), School of Medical Sciences, PO Box 6111, CEP 13083-970, Campinas, SP, Brazil. Electronic address: - - 2014
Although Bell's palsy (BP) is the most common cause of peripheral facial palsy (PFP), other etiologies merit investigation. A 60-year-old female patient presented with recurrent bilateral PFP. Although the patient had a history of acute myeloid leukemia (AML), she had initially been diagnosed with BP-related PFP and had been treated ...
Robles-Diaz Mercedes M Unidad de Gestión Clínica de Enfermedades Digestivas, Servicio de Farmacología Clínica, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga-IBIMA, Universidad de Málaga, Málaga, - - 2014
& Aims: Hy´s Law, which states that hepatocellular drug-induced liver injury (DILI) with jaundice indicates a serious reaction, is widely used to determine risk for acute liver failure (ALF). We aimed to optimize the definition of Hy´s Law and to develop a model for predicting ALF in patients with DILI. ...
Hmamouchi Ihsane I Department of Rheumatology, Lapeyronie Hospital, Montpellier I University, UMR 5535, EA2415, Montpellier, France; Mohammed V-Souissi University, Faculty of Medicine, Laboratory of Biostatistics, Clinical Research and Epidemiology, Rabat, Morocco. Electronic address: - - 2014
To assess the prevalence of remission in early arthritis, to evaluate the concordance across different criteria sets in defining this state, and to look for predictive factors for early and sustained remission. Patients from the ESPOIR cohort were followed-up every 6months. We analysed early remission and sustained remission in 3 ...
Lee Nora G NG Department of Urology, Children's National Medical Center, Washington, - - 2014
Radiographic workup for antenatal HN often includes VCUG to ascertain whether VUR is present. We sought to determine whether VCUG utilization might be limited to those at highest risk of having VUR. We hypothesize that VUR can be predicted by findings on renal/bladder US of hydroureter, renal dysmorphia, and/or duplication. ...
Ali Shahzad S Department of Urology and Transplantation, Jinnah Postgraduate Medical Centre, - - 2014
Objective: To assess the implementation of Percutaneous Nephrolithotomy (PCNL) in renal stone management and evaluate the factors for efficacy and safety of PCNL. Study Design: Case series. Place and Duration of Study: Department of Urology at Jinnah Postgraduate Medical Centre, Karachi, from January 2008 to December 2011. Methodology: Patients aged ...
Hussain Sajjad S Department of Cardiology, Armed Forces Institute of Cardiology - National Institute of Heart Diseases, - - 2014
This study was conducted to determine the frequency and describe the lesion characteristics, clinical factors, device responsible and outcomes for coronary perforations at Armed Forces Institute of Cardiology - National Institute of Heart Diseases (AFIC -NIHD) on all patients undergoing percutaneous coronary interventions (PCI) from 2007 to May 2012. A ...
Qureshi Muhammad Omar MO Department of Gastroenterology, Shifa International Hospital, - - 2014
Objective: To evaluate the correlation between Cancer Antigen-25 (CA-125) levels with the amount of ascites in patients with liver cirrhosis. Study Design: Observational, analytical study. Place and Duration of Study: Shifa International Hospital, Islamabad, from March 2012 to February 2013. Methodology: A total of 130 patients with liver cirrhosis (with ...
Modi S S Department of Microbiology, ICARE Institute of Medical Sciences & Research and Dr. B. C. Roy Hospital, Haldia, West Bengal, - - 2014
Purpose: The management of burn patients is always challenging for the clinician due to high risk of bacterial sepsis, multi-organ failure and death. Our objective was to study complement activation, C3 and interleukin-6 (IL-6) levels in burn patients and evaluate their role as prognostic markers. Materials and Methods: A total ...
Jang Dong Kee DK Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, - - 2014
Background/Aims: It has been demonstrated that cryptogenic pyogenic liver abscess (PLA) is associated with colonic mucosal defect, especially colorectal cancer (CRC). Therefore, the screening of CRC in patients with cryptogenic PLA is important. This study was to investigate whether computed tomographic colonography (CTC) has value as a follow-up modality as ...
Chen Wei-Hsi WH Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Kaohsiung, Taiwan - - 2014
Background: Although it has been established that antiphospholipid antibodies (APAbs) bind to and modulate the signaling of cerebellar neurons in vitro, the clinical correlation between increased APAbs and cerebellar ataxia has rarely been investigated. Methods: We reviewed 10 patients presenting with cerebellar ataxia with increased blood APAbs from our database ...
Hong Sung-Jin SJ Division of Cardiology, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, - - 2014
Peak oxygen uptake (peak VO₂) and ventilatory inefficiency (VE/VCO₂ slope) have proven to be strong prognostic markers in patients with chronic heart failure (CHF). Recently increased red cell distribution width (RDW) has emerged as an additional predictor of poor outcome in CHF. We sought to evaluate the relationship between RDW ...
Kim Changhwan C Department of Pulmonary and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea. ; Lung Research Institute of Hallym University College of Medicine, Chuncheon, - - 2014
A recent study demonstrated that exertional desaturation is a predictor of rapid decline in lung function in patients with chronic obstructive pulmonary disease (COPD); however, the study was limited by its method used to detect exertional desaturation. The main purpose of this study was to explore whether exertional desaturation assessed ...
Park Hee-Jin HJ Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, - - 2014
To investigate clinical implications of delta neutrophil index (DNI) to discriminate adult onset Still's disease (AOSD) from sepsis. We reviewed the medical records of 13 patients with AOSD and 33 gender and age-matched patients with sepsis. In all subjects, microbial tests were performed to exclude or confirm sepsis. All laboratory ...
Park Hyung Jun HJ Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea. ; Department of Neurology, Yonsei University College of Medicine, Seoul, - - 2014
This study was designed to investigate the characteristics of Korean adrenomyeloneuropathy (AMN) patients. We retrospectively selected 12 Korean AMN patients diagnosed by clinical analysis and increased plasma content of very long chain fatty acids. All 12 patients were men. Patient ages at symptom onset ranged from 18 to 55 years. ...
Seo Kwon-Duk KD Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, - - 2014
Clopidogrel is metabolized by the hepatic cytochrome P450 (CYP) system into its active thiol metabolite. CYP3A4 is involved in the metabolism of both clopidogrel and dihydropyridine calcium channel blockers (CCBs). A few reports have suggested an inhibitory interaction between CCBs and clopidogrel. Accordingly, the aim of this study was to ...
Meyer Anna L AL Heart Center Leipzig University, Clinic for Heart Surgery, Leipzig, - - 2014
The aim of this study was to determine whether differences in continuous flow left ventricular assist devices (LVADs) may lead to differences in the von Willebrand profile and the occurrence of bleeding and thromboembolic events. The HeartMate II (Thoratec Corp., Pleasanton, California) and HeartWare Ventricular Assist Device (HVAD) (HeartWare, Inc., ...
Tanaka Akihito A Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Cardiology, Handa City Hospital, Handa, Japan; Department of Cardiology, Okazaki City Hospital, Okazaki, - - 2014
The high prevalence of significant asymptomatic coronary artery disease (CAD) has been reported in patients with end-stage renal disease (ESRD) at the initiation of dialysis. However, the approach to evaluate asymptomatic CAD for these patients has not been established. The aim of this study is to assess the applicability of ...
Weber Michael H MH Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, - - 2014
Study Design Retrospective cross-sectional study. Clinical Question What is the prevalence of cervical spondylosis (CS) and thoracolumbar (TL) spinal deformity in an administrative database during a 4-year study period? Is the prevalence of CS or TL deformity higher in patients who have the other spine diagnosis compared with the overall study population? ...
Hishitani Takashi T Department of Cardiology, Saitama Children's Medical Center, Saitama, - - 2014
We verified the feasibility of telediagnosis of fetal disease by (i) grading telediagnosis by a pediatric cardiologist into five confidence levels; and (ii) comparison of fetal telediagnosis with hands-on fetal diagnosis or postnatal diagnosis. In 114 patients suspected of having heart disease (real time, n = 15; recorded image transmission, ...
Ageno Walter W Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy. Electronic address: - - 2014
Splanchnic vein thrombosis (SVT) is a serious complication in patients with paroxysmal nocturnal hemoglobinuria (PNH). Mutant PNH clones can be associated with an increased risk of SVT even in the absence of overt disease, but their prevalence in non-selected SVT patients remains unknown. Patients with objective diagnosis of SVT and ...
Orenstein Marissa - - 2014
Gaucher disease, an autosomal recessive condition due to deficiency of lysosomal glucocerebrosidase, is a multisystemic disease, with variable age of onset, severity and progression. It is classified into subtypes delineated by the absence (type 1) or presence (type 2 and 3) of primary nervous system involvement.The ethnically diverse, largely immigrant ...
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