Search Results
Results 151 - 200 of 18173
1 2 3 4 5 6 7 8 9 10 >
Ivanoiu Adrian A Neurology Department, Saint Luc University Hospital, Université catholique de Louvain, Brussels, Belgium Institute of Neuroscience, Université catholique de Louvain, Brussels, - - 2014
Background: New diagnostic criteria for predemential Alzheimer's disease (AD) advocate the use of biomarkers. However, the benefit of using biomarkers has not been clearly demonstrated in clinical practice. Objective: To investigate whether a combination of biomarkers may be helpful in classifying a population of non-demented patients attending a Memory Clinic. ...
Aulbert Wiebke W Department of Neuropediatrics, University Children's Hospital, Ruhr University, Bochum, - - 2014
Leigh syndrome (MIM 25600), also known as infantile subacute necrotizing encephalomyelopathy, is a neurodegenerative disorder with characteristic bilateral symmetric lesions in basal ganglia and subcortical brain regions. It is commonly associated with systemic cytochrome c oxidase (COX) deficiency and mutations in the SURF1 gene (MIM 185620), encoding a putative assembly ...
Miller Deborah M DM Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, USA - - 2014
Because multiple sclerosis (MS) is variable and unpredictable, if symptom worsening could be predicted, patients may feel better prepared to manage changes in function. The objective of this paper is to study the prediction of walking impairment in MS. We retrieved data for all MS patients at our center (2008-2009), ...
Oliveira Michelle J C MJ Post-Graduation Program in Medical Sciences, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; School of Medicine, Master in Collective Health, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil; Department of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil; São José Infectious Disease Hospital, Fortaleza, Ceará, Brazil; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, - - 2014
Visceral leishmaniasis (VL) is a re-emerging zoonosis of worldwide distribution. Monocyte chemotactic protein-1 (MCP-1) and malondialdehyde (MDA) are inflammation biomarkers that have never been investigated in VL. The aim of this study is to investigate the association between renal abnormalities and inflammation biomarkers in VL. This study is a preliminary ...
Sonnino Chiara - - 2014
Anakinra, the recombinant form of the human IL-1 receptor antagonist, blunts the acute systemic inflammatory response in patients with ST-segment elevation myocardial infarction (STEMI), by determining a fall in peripheral blood leukocyte and plasma C reactive protein (CRP) levels. The aim of the present study was to determine the effects ...
Marafini I I Department of Systems Medicine, University of Rome "Tor Vergata", Rome, - - 2014
The clinical presentation of organic and functional intestinal disorders can overlap and clinicians often rely on invasive and time-consuming procedures to make a final diagnosis. Regenerating islet-derived 3-alpha (Reg3α) is detectable in the circulation of patients with intestinal graft-versus host disease and patients with inflammatory bowel disease (IBD). To determine ...
Rhodes L E LE Dermatology Centre, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, - - 2014
Low vitamin D status is prevalent in winter-time in populations at northerly latitudes. Photosensitive patients are advised to practise sun-avoidance, but their sunlight exposure levels, photoprotective measures and resulting vitamin D status are unknown. Examine seasonal vitamin D status in photosensitive patients relative to healthy individuals and quantitatively assess behavioural ...
Nannucci S S NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, - - 2014
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease caused by NOTCH3 mutations. There are no clinical and neuroimaging findings pathognomonic of the disease. The aim of this paper was to provide a description of a group of NOTCH3-negative patients with a phenotype ...
Banack Sandra Anne SA Institute for Ethnomedicine, Box 3464, Jackson Hole, WY 83001, USA. Electronic address: - - 2014
Cyanobacteria produce the neurotoxic amino acid β-N-methylamino-l-alanine (BMAA), which in contaminated marine waters has been found to accumulate in shellfish. Exposure to BMAA has been associated with an increased risk of neurodegenerative disease. Analysis of blinded samples found BMAA to be present in neuroproteins of individuals who died from ALS ...
Yazıcı Dilek D Section of Endocrinology and Metabolism, Marmara University Medical School, İskele Sok. Hüseyin Ayaz Apt. No:22/8 Caddebostan/Istanbul, Istanbul, Turkey, - - 2014
Epicardial adipose tissue (EAT) thickness is a novel cardiovascular risk indicator, whereas carotid intima media thickness (CIMT) is a known marker of subclinical atherosclerosis. The aim of this study was to measure EAT thickness and CIMT in subclinical hypothyroid (SCH) patients and to determine the effect of restoration of the ...
Liu Hui H Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, GuangZhou, GuangDong, - - 2014
To analyze 15 cases of malposition of branch pulmonary arteries (MBPA) for the hospital-based prevalence, clinical information, surgical outcome, imaging findings, associated cardiovascular and airway abnormalities on cardiovascular computed tomography angiography (CCTA). We retrospectively searched for patients with MBPA from our database consisting of patients referred for CCTA due to ...
Shin Hye-Young HY Department of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South - - 2014
The aim of this work is to compare the thinning patterns of the ganglion cell inner-plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) as measured using Cirrus high-definition optical coherence tomography (HD-OCT) in patients with visual field (VF) defects that respect the vertical meridian. Twenty eyes of 11 ...
Kovarik Johannes J JJ Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, - - 2014
Blockade of the renin-angiotensin system (RAS) exerts beneficial effects in patients with mild-to-moderate chronic kidney disease, yet evidence suggesting a similar benefit in haemodialysis (HD) patients is not available. Furthermore, knowledge of the effects of RAS blockade on systemic RAS components in HD patients is limited. Analysis of the quantity ...
Wu Jashin J JJ Department of Dermatology, Kaiser Permanente Los Angeles Medical Center, Los Angeles , - - 2014
Abstract Background: Psoriasis may or may not be associated with a higher risk for myocardial infarction (MI). We sought to assess differences in MI incidence between control, mild psoriasis, and severe psoriasis patients. Methods: We performed a retrospective cohort study of Kaiser Permanente Southern California members with psoriasis between 1-JAN-04 ...
Nistal Manuel M a Hospital La Paz, Universidad Autónoma de Madrid, - - 2014
Abstract Abstract Varicocele is characterized by elongation, dilatation, and tortuosity of the veins draining the testis and its covers, causing circulatory reflux along the inner spermatic vein (1). Varicocele results in progressive testicular lesions and, if untreated, can lead to testicular atrophy (2). Varicocele is considered the most frequently identified ...
Bourgeois James A - - 2014
The authors examined the frequency of neuroimaging findings of cortical atrophy and/or cerebrovascular disease in patients with delirium with hypovitaminosis D and normal vitamin D levels. Of 32 patients with delirium with hypovitaminosis D who were neuroimaged, 91.4% had neuroimaging findings, despite only five cases having a comorbid diagnosis of ...
Kacar Emre E Department of Radiology, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, - - 2014
Our aim was to investigate whether neurological alteration in patients with obstructive sleep apnoea syndrome (OSAS) with apparently normal cerebral and cerebellar structures can be assessed by means of apparent diffusion coefficient (ADC) measurement, and to investigate the association between OSAS severity and ADC values. Following the acquisition of diffusion-weighted ...
Gleissner Christian A CA Department of Cardiology, University Hospital, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany, - - 2014
Low anti-phosphorylcholine (PC) IgM plasma levels have been associated with increased incidence of adverse events in coronary artery disease (CAD). The underlying mechanisms are unclear. We hypothesized that atheroprotection mediated by anti-PC IgM antibodies is associated with reduced vascular remodeling and therefore tested whether anti-PC IgM plasma levels independently predict ...
Jacobs Victoria V Intermountain Heart Institute, Intermountain Medical Center, Murray, - - 2014
The mechanisms behind the association of AF and dementia are unknown. One possibility is that exposure to chronic microembolism or microbleeds resulting in repetitive cerebral injury that is manifest by cognitive decline. We hypothesized that AF patients with a low percentage of time in therapeutic range (TTR) are at higher ...
Gouveia Ana A Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address: - - 2014
Intracranial atherosclerotic disease is a common cause of stroke; its incidence and prevalence vary widely by ethnicity. The aim of our study was to analyze the recurrence rate of cerebrovascular events in patients with symptomatic and asymptomatic intracranial stenosis (IS). We conducted a historical cohort study including all patients admitted ...
De Caterina Raffaele R Institute of Cardiology and Center of Excellence on Aging, G. d'Annunzio, University Chieti-Pescara, Pisa, Italy Fondazione G. Monasterio, Pisa, - - 2014
Combined oral anticoagulant (OAC) and antiplatelet (AP) therapy is generally discouraged in atrial fibrillation (AF) outside of acute coronary syndromes or stenting because of increased bleeding. We evaluated its frequency and possible reasons in a contemporary European AF population. The PREvention oF thromboembolic events-European Registry in Atrial Fibrillation (PREFER in ...
Xia Jiadong J Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of Andrology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, - - 2014
The pathologic mechanisms of primary premature ejaculation (PPE) are complex and multifactorial, and hyperactivity of the sympathetic nervous system is one of the mechanisms. To examine the effects of sertraline on sympathetic nervous system activity and assess the predictive value of the sympathetic skin response located in the penis (PSSR) ...
Zhang Wanfen W National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China; - - 2014
This study aimed to identify urinary microRNAs (miRNAs) as biomarkers for FSGS disease activity. Candidate urinary miRNAs were identified in pooled urine samples from patients with active FSGS (FSGS-A) and FSGS in remission (FSGS-CR), and were then validated using individual samples. Their levels were compared both under different treatment responses ...
Xiong Li Shou LS Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, - - 2014
Most of previous studies exploring the overlap of functional gastrointestinal disorders (FGIDs) only focused on overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). Furthermore, there are no report about the spectra and overlap for the entire FGIDs in China. In this study, we sought to explore the spectra, ...
Fadda S S Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Egypt-Cairo-Nasr city- emtedad ramsis street-4 elgabal elakhdar building, Cairo , - - 2014
To detect the incidence of premature atherosclerosis in systemic lupus erythematosus (SLE) patients and to study its association with disease activity and damage indices. This study involved 50 adult female SLE patients with mean age 26.24 ± 8.63 years and mean disease duration 3.44 ± 4.01 years. The control group comprised 25 healthy adult females. All patients were ...
Guan Wei-Jie WJ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, - - 2014
Correlation between fractional exhaled nitric oxide (FeNO) and responsiveness to inhaled leukotriene D4 (LTD4 ) and methacholine (MCh) might be different. To determine the correlation between FeNO and airway responsiveness to LTD4 and MCh, and to compare the airway responsiveness to inhaled LTD4 and MCh and FeNO in non-smokers, patients ...
El-Salhy Magdy M Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Stord 54 09, - - 2014
Several abnormalities have been demonstrated in the intestines of patients with irritable bowel syndrome (IBS); however, the endocrine cells in the stomachs of these patients have not been investigated. The aim of the present study was to determine whether there are any abnormalities in the endocrine cells of the stomachs ...
Samoš Matej M Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Kollárova 2, 036 59, Martin, Slovak Republic, - - 2014
Dabigatran, a new direct thrombin inhibitor, achieves strong anticoagulation that is more predictable than warfarin. Nevertheless, a patient on dabigatran therapy (DT) may suffer from thrombotic or bleeding events. The routine monitoring of DT is not recommended, and standard coagulation tests are not sensitive enough for the assessment of DT ...
Martinez Melissa A MA Indiana University School of Medicine, Indianapolis, - - 2014
Rare cases of azithromycin-induced hepatotoxicity have been reported, with variable clinical and histological features. We characterized clinical features and outcomes of azithromycin-induced liver injury. We identified patients with azithromycin-induced liver injury from the Drug-Induced Liver Injury Network Prospective Study who had causality scores of definite, highly likely, or probable. Demographic, ...
de Wit Djoeke - - 2014
GIST patients often undergo GI-surgery. Previous studies have shown that imatinib and nilotinib exposures were decreased in GIST patients with prior major gastrectomy. We investigated whether major gastrectomy influences the exposure to sunitinib and its active metabolite SU12662. Pharmacokinetic data from 305 GIST patients included in 4 phase I-III trials ...
Mirbagheri Seyed Sina SS Division of Gastroenterology, Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, North Sa'adi Street, 13145-784, Tehran, - - 2014
There is no consensus regarding the benefit of eradicating Helicobacter pylori (H. pylori) infection in patients with functional dyspepsia (FD). We intended to compare the symptom response to H. pylori eradication in FD patients in presence or absence of microscopic duodenitis (MD). Patients with dyspepsia, normal upper gastrointestinal endoscopy and ...
He Shushu S State Key Laboratory of Oral Disease, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, 610041,China.. Electronic address: - - 2014
The involvement of central nervous system in the pathophysiology of temporomandibular disorders (TMD) has been noticed. TMD patients have been shown dysfunction of motor performance and reduced cognitive ability in neuropsychological tests. The aim of this study is to explore the spontaneous neural activity in TMD patients with centric relation ...
Apostle Kelly L KL University of British Columbia, New Westminster, BC, Canada - - 2014
The etiology of peritalar subluxation (PTS) is poorly understood and likely mutifactorial. An anatomic predisposition for posterolateral subluxation of the hindfoot has not been previously described or investigated. The aim of the current study was to describe the morphology of the subtalar joint axis (STJA) in patients with symptomatic PTS ...
Angriman Imerio I Imerio Angriman, Department of Surgery, Gastroenterology and Oncology, University of Padova, 35128 Padova, - - 2014
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the surgical treatment of choice for many patients with medically refractory ulcerative colitis (UC) and familial adenomatous polyposis (FAP). UC patients with IPAA (UC-IPAA) are, nevertheless, susceptible to inflammatory and noninflammatory sequelae such as pouchitis, which is only rarely noted in ...
Yamamoto Masaaki M Katsuta Hospital Mito GammaHouse, Hitachi-naka, Japan; Department of Neurosurgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan. Electronic address: - - 2014
We tested the validity of five prognostic indices, Recursive Partitioning Analysis (RPA), Score Index for Radiosurgery (SIR), Basic Score for Brain Metastases (BSBM), Graded Prognostic Assessment (GPA) and Modified-RPA, for patients with repeat stereotactic radiosurgery (re-SRS). For this study, we used our database including 804 patients undergoing gamma knife re-SRS ...
Perry Ariane A *Université Paris Diderot-Sorbonne Paris Cité, UMR 1149, 75018 Paris, France †Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, 75019 Paris, France ‡INSERM, UMR1149, 75018 Paris, France §Department of Electron Microscopy, Université François Rabelais, 37032 Tours, France ||Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, 75015 Paris, France ¶Université Paris Descartes-Sorbonne Paris Cité, 75015 Paris, France #Université Paris Diderot, UMR 698, CHU X. Bichat, 75018 Paris, France. 1these authors contributed - - 2014
Microvillous inclusion disease (MVID) is a cause of intractable diarrhea in infancy. In its classic form, the disease is characterised by a severe persistent watery diarrhea starting within the first days of life. Parenteral nutrition and small bowel transplantation are the only known treatments of affected children. Histologically, Periodic acid-schiff ...
Namiuchi Shigeto S Department of Cardiology, Sendai City Medical Center, Sendai, - - 2014
By combining C-reactive protein and serum albumin concentrations, the Glasgow Prognostic Score (GPS) provides valuable predictions of prognosis in patients with cancer. Both systemic inflammatory response and malnutrition are also common in patients with heart failure. We evaluated the efficacy of the GPS for predicting the prognoses of patients with ...
Baudhuin Linnea M LM Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, - - 2014
Purpose:Marfan syndrome is a systemic disorder that typically involves FBN1 mutations and cardiovascular manifestations. We investigated FBN1 genotype-phenotype correlations with aortic events (aortic dissection and prophylactic aortic surgery) in patients with Marfan syndrome.Methods:Genotype and phenotype information from probands (n = 179) with an FBN1 pathogenic or likely pathogenic variant were ...
Tokgöz Ozlem - - 2014
Aims: To evaluate the value of spleen and liver apparent diffusion coefficients (ADC) in chronic liver disease patients, with and without hepatocellular carcinoma (HCC), and to investigate the use of diffusion-weighted imaging (DWI) in the diagnosis and follow-up of hepatic fibrosis. Materials and methods: This study population comprised 68 chronic ...
Qiao Xin-Wei - - 2014
Pancreatic neuroendocrine tumors (PNETs) are a group of rare tumors. Chromogranin A (CgA) was considered as the most practical and useful serum tumor marker in PNET patients. But peripheral blood levels of CgA are not routinely tested in Chinese patients with PNETs. This study was to assess the diagnostic value ...
Morray Brian H BH Department of Cardiology, Boston Children's Hospital, Boston, Mass, - - 2014
Peripheral pulmonary artery stenosis (PPS) is a heterogeneous disease associated with numerous clinical or syndromic disorders including Williams syndrome. Previous studies focusing on patients with Williams syndrome have documented spontaneous improvement in branch pulmonary artery (PA) stenosis and right ventricular pressure. The goal of this study is to identify angiographic ...
Kallio Merja M Department of Pediatrics, Oulu University Hospital, Oulu, - - 2014
Neurally adjusted ventilatory assist (NAVA) is a ventilation mode which provides respiratory support proportional to the electrical activity of the diaphragm (Edi). The aims of this trial were to assess the feasibility of aiming at peak Edi between 5 and 15 µV during NAVA in clinical practice, to study the effect ...
Nakada Takafumi T Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-ku, Nagoya, 466-8550, Japan, - - 2014
Ménière's disease (MD) is characterized by episodic vertigo, fluctuating hearing loss and tinnitus. Vestibular migraine (VM) is a relatively new disorder that is characterized by episodic vertigo or dizziness, coexisting migraine and absence of hearing loss. It is occasionally difficult to distinguish between VM and vestibular MD with headache. Because ...
Moccia M M Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, - - 2014
Uric acid (UA) has been studied extensively as a valuable biomarker of Parkinson's disease (PD), but its relationship with non-motor symptoms (NMS) in de novo PD has been poorly investigated. Our aim was to evaluate the usefulness of baseline serum UA as a marker of NMS progression in newly diagnosed ...
Wang Jingting J Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, - - 2014
Serum exosomes containing noncoding RNA (ncRNA) play an important role in both physiological and pathological conditions. However, biological function of exosomal ncRNA remains unclear. The aim of the study was to investigate the prognostic and diagnostic values of exosomal ncRNA by comparing the amounts of exosomal miR-21 and HOTAIR in ...
Huhn K K Department of Neurology, University of Erlangen, Erlangen, - - 2014
Some 3%-10% of patients with multiple sclerosis (MS) experience disease onset before the age of 18 years ('early' onset MS, EOMS). Optical coherence tomography is a non-invasive method to measure retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) and may be useful to differentiate axonal and neuronal damage ...
Duan Rui-Dong - - 2014
Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human liver and released in the bile. The enzyme may have anti-tumour and anti-inflammatory effects in colon and its levels are decreased in patients ...
Kessoku Takaomi T Takaomi Kessoku, Yuji Ogawa, Masato Yoneda, Kento Imajo, Atsushi Nakajima, Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, - - 2014
To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease (NAFLD) patients. A total of 1048 patients with liver-biopsy-confirmed NAFLD were enrolled from nine hepatology centers in Japan (stage 0, 216; stage 1, 334; stage 2, 270; stage 3, 190; stage 4, 38). The ...
Aggarwal Ashish A *Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH; †Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH; ‡Department of Cardiology, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH; and §Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, - - 2014
Inflammation is increasingly being recognized as an important factor in the pathogenesis of atherosclerosis and outcome of percutaneous coronary intervention (PCI). The purpose of this study was to compare conventional risk factors and PCI outcomes in patients with inflammatory bowel disease (IBD) and non-IBD controls with angiographically proven coronary artery ...
Pastore Anna A Metabolomic and Proteomic Unit, Children's Hospital "Bambino Gesù", IRCCS, P.zza S. Onofrio, 4, 00165, Rome, Italy, - - 2014
Hyperhomocysteinemia (hHcy) is a risk factor in the progression of chronic kidney disease (CKD). In type 2 diabetes (T2D), hHcy is strongly associated with increased risk of cardiovascular disease. Vitamin B12 and folic acid supplementation have been reported to lower homocysteine (tHcy) levels, but no data on plasma tHcy, cysteine ...
1 2 3 4 5 6 7 8 9 10 >