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Van Laere Koen K KU Leuven, Nuclear Medicine and Molecular Imaging, University Hospital Leuven, Leuven, Belgium3KU Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium4VIB, - - 2014
IMPORTANCE Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily affecting the motor system, with extramotor involvement to a variable extent. Biomarkers for early differential diagnosis and prognosis are needed. An autosomal dominant hexanucleotide (GGGGCC) expansion in the noncoding region of the chromosome 9 open reading frame 72 (C9orf72) gene ...
Silva Joyce M JM Laboratory of Leishmaniasis, Institute of Tropical Diseases "Natan Portella", Federal University of Piauí, Teresina, PI, Brazil; Department of Biology, Federal University of Piauí, Floriano at Floriano, PI, Brazil; Maternal and Childhood Department, Federal University of Piauí, Teresina, PI, Brazil; Laboratory of Molecular Biology, Nucleus of Tropical Medicine, Federal University of Pará, Belém, PA, Brazil; Department of Community Medicine, Federal University of Piauí, Teresina, PI, - - 2014
Kala-azar or visceral leishmaniasis, found mostly throughout the Indian Subcontinent, East Africa, and Brazil, kills 20,000-40,000 persons annually. The agents, Leishmania donovani and Leishmania infantum, are obligatory intracellular protozoa of mononuclear phagocytes found principally in the spleen and bone marrow. Protracted fever, anemia, wasting, hepatosplenomegaly, hemorrhages, and bacterial co-infections are ...
Higashiyama Yukie Y Faculty of Human Life and Environment, Nara Women's University, Kita-Uoya Nishi-machi, Nara, - - 2014
A nutritional assessment of pediatric patients with cancer is quite important to improve their outcome. However, a longitudinal nutritional study during treatment is still limited. The purpose of this study was to investigate the longitudinal changes in anthropometric measures and serum albumin levels during chemotherapy in patients with acute lymphoblastic ...
Shiono Nobuko N Department of Pediatric Cardiology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka 594-1101, - - 2014
To clarify the outcomes of patients with cardiovascular malformations (CVMs) among those with congenital diaphragmatic hernia (CDH) who are indicated for the Fontan procedure. The study subjects included 76 CDH patients with CVMs recruited from a national survey of 614 CDH patients. The outcomes were evaluated between two groups divided ...
Pan Q Q Department of Infectious Disease, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, - - 2014
Interleukin-21 (IL-21) participates in tissue damage in various immune-mediated diseases. Its role in the pathogenesis of chronic active hepatitis B (CAHB) has not been clarified. The frequency of circulating IL-21(+) T cells and the levels of serum and intrahepatic IL-21 have been characterized in 70 CAHB patients, 32 inactive carrier ...
Zhang Wen-Ming WM Department of Pediatrics, Renji Hospital Affiliated to Shanghai Jiao-Tong University School of Medcine , Shanghai , - - 2014
Abstract Context: Atopy and systemic onset juvenile idiopathic arthritis (SoJIA) are two potential outcomes of a dysregulated immune system. Although rare, SoJIA causes 60% of the morbidity of JIA patients which exhibit a wide heterogeneity of prognosis and treatment. Co-morbidities can complicate the responses to therapy. Objective: To study the ...
Witting N N Department of Neurology and Neuromuscular Research Unit, University of Copenhagen, Rigshospitalet, Copenhagen, - - 2014
To assess skeletal muscle weakness and progression as well as the cardiopulmonary involvement in oculopharyngeal muscular dystrophy (OPMD). Cross-sectional study including symptomatic patients with genetically confirmed OPMD. Patients were assessed by medical history, ptosis, ophthalmoplegia, facial and limb strength, and swallowing capability. Cardiopulmonary function was evaluated using forced expiratory capacity ...
Falchi Lorenzo L Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United - - 2014
Richter's syndrome (RS) is associated with poor outcome. The prognosis of patients with histologically aggressive chronic lymphocytic leukemia (CLL), HAC, has not been studied. We aimed to correlate 2-Deoxy-2-[(18)F]fluoroglucose/positron emission tomography (FDG/PET) data, histological diagnosis, clinical characteristics and survival in patients with CLL. 332 patients with CLL were histologically classified ...
Olde Rikkert Marcel G M MG Radboud Alzheimer Center, Department of Geriatric Medicine, Radboud University Hospital, Nijmegen, The - - 2014
Background: Studies on the systemic availability of nutrients and nutritional status in Alzheimer's disease (AD) are widely available, but the majority included patients in a moderate stage of AD. Objective: This study compares the nutritional status between mild AD outpatients and healthy controls. Methods: A subgroup of Dutch drug-naïve patients ...
Ladino Lady Diana LD Neurology Department, Hospital Pablo Tobón Uribe, Medellin, Antioquia, - - 2014
The coexistence of focal and generalized epilepsy is rare. We report on a 17-year-old male with drug-resistant focal epilepsy and idiopathic generalized epilepsy (IGE). He began to experience generalized tonic-clonic seizures (GTCS) at the age of 3 years, with a good response to phenobarbital. At the age of 14 years, ...
Christensen Ann Marlene Gram AM From the Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital , Aarhus , - - 2014
Background: The Centor criteria and the streptococcal rapid antigen detection test (RADT) are commonly used to differentiate sore throat patients with group A streptococci (GAS) from patients with other pathogens. We aimed to investigate if procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC), and absolute neutrophil count (ANC) ...
Sakuma Satoru S Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: - - 2014
Pediatric focal epilepsies often involve more extratemporal regions than adult epilepsies. This study aims to investigate the population of oligodendroglia-like cells (OLCs) in the pediatric focal epilepsy patients requiring surgery. We hypothesize that OLCs are one of the factors that extend the pediatric epileptic network in intractable epilepsy. Thirty (18 ...
Bilgin Gorkem - - 2014
Today, identified risk factors for normal-tension glaucoma (NTG) include abnormal ocular blood flow, abnormal blood coagulation, systemic hypotension, ischemic vascular disorders, and autoimmune diseases. However, pathogenesis of the condition remains unclear. On the other hand, there are also a few studies suggesting that the obstructive sleep apnea syndrome (OSAS) may ...
Morris Dominic - - 2014
Diagnosing a specific type of Interstitial Lung Disease (ILD) is a challenging process and often necessitates that a Video-assisted Thoracoscopic Surgery (VATS) Lung Biopsy be performed. By analysing the proportion of patients who have their treatment changed after undergoing a VATS lung biopsy, this study aimed to determine the utility ...
Knopf Andreas A Department of Otorhinolaryngology Head and Neck Surgery, Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, Ismaningerstrasse 22, 81675, Munich, Germany, - - 2014
There are many controversies in head and neck granulomatosis with polyangiitis (HN-GPA). Diagnostic/therapeutic regimens vary due to limited knowledge about the special properties of HN-GPA. 28 patients were diagnosed with GPA accordingly. Anti-neutrophil-cytoplasmatic-antibody (ANCA), anti-peroxidase-antibody (anti-PR3) and biopsies were performed for all patients and set into clinical context. 14 patients ...
Osadnik Tadeusz T IIIrd Department of Cardiology, Medical University of Silesia in Katowice, Medical Faculty in Zabrze, Silesian Centre for Heart Diseases, Ul. Marii Skłodowskiej Curie 9, 41-800, Zabrze, Poland, - - 2014
The aim was to assess the predictive value of estimated glomerular filtration rate (eGFR) using two formulas: modification of diet in renal disease (MDRD) and chronic kidney disease epidemiology collaboration (CKD-EPI), in a population with stable coronary artery disease (SCAD) undergoing percutaneous coronary revascularization (PCI). The analyzed cohort included 3,141 ...
Wei Wei W Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 510080 Guangdong, - - 2014
The aim of the study was to describe the complex electrophysiological features of accessory pathways (APs) in adult Ebstein's anomaly (EA).METHODS AND RESULTS: We performed a retrospective study of 17 consecutive adult EA cases with APs who underwent electrophysiological study and radiofrequency catheter ablation (RFCA) from November 2011 to May ...
Shen Q Q Radiology Department, Children's Hospital of Fudan University, 399 Wanyuan Road, 201102, Minhang District, Shanghai, People's Republic of - - 2014
The aim of this study was to evaluate the clinical and imaging features of patients with cardiac rhabdomyomas associated with tuberous sclerosis complex. The clinical and imaging characteristics of seven patients with cardiac rhabdomyomas associated with tuberous sclerosis complex between June 2008 and January 2013 were reviewed. The data collected ...
Huijts Marjolein - - 2014
Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD) and have been related to cSVD severity. A higher number of EPVS were related to decreased cognition in healthy elderly, but this has never been investigated in patients at high risk of cSVD. We included 189 patients ...
Lingman Framme Jenny J Department of Pediatrics, Halland Hospital Halmstad, S-301 85, Halmstad, Sweden, - - 2014
Population-based newborn screening using T-cell receptor excision circles (TREC) identifies infants with severe T-lymphopenia, seen in severe combined immunodeficiencies (SCID), but also infants with the 22q11 deletion syndrome (22q11DS). Methods for analysis of kappa-deleting recombination excision circles (KREC) help identifying infants with B-lymphopenia. We aimed to evaluate the occurrence of ...
Rosenstein Rachel K RK Department of Dermatology, Langone School of Medicine at New York University, New York, NY, - - 2014
At the intersection of atopy and autoimmunity, we present a patient with seronegative rheumatoid arthritis (RA) who developed hypereosinophilia, without evidence of other etiologies, as she became rheumatoid factor (RF) positive. Although the magnitude of eosinophilia in patients with RA has been thought to reflect the severity or activity of ...
Choi Jin Woong JW Department of Otolaryngology-Head and Neck Surgery, Chungnam National University School of Medicine, Daejeon, South - - 2014
Acute unilateral vestibular loss presents as ocular torsion (OT) and caloric unilateral weakness (UW). However, the amount of OT is frequently dissociated from UW depending on when the examination was performed and the extent and cause of the vestibular lesion. This study evaluated the relationship between OT and UW in ...
Ozcan K Murat KM ENT Clinic, Ankara Numune Education and Research Hospital, Ankara, - - 2014
The aim of this study is to investigate the thyroid functions and its correlation with polysomnography findings in obstructive sleep apnea patients. This study was conducted on 203 patients evaluated with the complaints of snoring, witnessed apnea and daytime sleepiness and established polysomnography (PSG) indication between May 2008 and August ...
Kapusuz Gencer Zeliha Z Department of Otolaryngology, Head and Neck Surgery, Bozok University Medical Faculty, Adnan Menderes Bulvarı No: 42, Yozgat, Turkey, - - 2014
The aim of this study was to investigate the relations between nitric oxide (NO) and leptin levels in a cohort of untreated adult Obstructive sleep apnea syndrome (OSAS) patients. Between June 1, 2012, and January 1, 2013, we evaluated a total of 58 subjects including 36 OSAS patients and 22 ...
Jarius Sven - - 2014
Susac syndrome (SuS) is a rare disorder thought to be caused by autoimmune-mediated occlusions of microvessels in the brain, retina and inner ear leading to central nervous system (CNS) dysfunction, visual disturbances due to branch retinal artery occlusions (BRAO), and hearing deficits. Recently, a role for anti-endothelial cell antibodies (AECA) ...
Vegesna Anil K AK Department of Medicine (Gastroenterology), The Feinstein Institute for Medical Research, Hofstra North Shore-LIJ School of Medicine, 350 Community Drive, Manhasset, NY, 11030, USA, - - 2014
Little is known about the role of muscularis mucosa at the gastroesophageal junction (GEJ). To evaluate the movement of the mucosa/muscularis-mucosa/submucosa (MMS) at the GEJ in normal subjects and in patients with gastroesophageal reflux disease (GERD). Gastroesophageal junctions of 20 non-GERD subjects and 10 patients with GERD were evaluated during ...
Long Youming Y Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience and The Second Affiliated Hospital of GuangZhou Medical University, and Department of Neurology, The Second Affiliated Hospital of GuangZhou Medical University, GuangZhou, PR - - 2014
Objective: We assessed the clinical significance of antineutrophil cytoplasm antibodies (ANCA) in patients with idiopathic inflammatory-demyelinating disease (IIDD). Methods: A consecutive cohort of 269 subjects with IIDD and 595 controls was analyzed retrospectively. Results: Among all subjects, ANCA positivity rates were low [9.5% in a perinuclear pattern (pANCA) and 2.3% ...
Tak Hyung Jun - - 2014
The role of the arcuate fasciculus (AF) in the dominant hemisphere in stroke patients with aphasia has not been clearly elucidated. We investigated the relation between language function and diffusion tensor tractography(DTT) findings for the left AF in chronic stroke patients with aphasia. Twenty five consecutive right-handed stroke patients with ...
Pal Gian G Department of Neurology, Medstar Washington Hospital Center, 110 Irving Street N.W., Washington, DC, 20010, USA, - - 2014
In 1949, asterixis was first described in patients with hepatic encephalopathy. It was quickly recognized that this phenomenon also occurs in other generalized encephalopathies and sometimes results from structural brain lesions. This paper is a study of asterixis in the general neurology clinic and on the inpatient neurology consultation service. ...
Zheng Su-Jun SJ Su-Jun Zheng, Shuang Liu, Mei Liu, Jun-Feng Li, Feng Ren, Yu Chen, Zhong-Ping Duan, Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, - - 2014
To determine the prognostic value of circulating indicators of cell death in acute-on-chronic liver failure (ACLF) patients with chronic hepatitis B virus (HBV) infection as the single etiology. Full length and caspase cleaved cytokeratin 18 (detected as M65 and M30 antigens) represent circulating indicators of necrosis and apoptosis. M65 and ...
El-Salhy Magdy M Magdy El-Salhy, Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, 54 09 Stord, - - 2014
To study the ileal endocrine cell types in irritable bowel syndrome (IBS) patients. Ninety-eight patients with IBS (77 females and 21 males; mean age 35 years, range 18-66 years) were included, of which 35 patients had diarrhea (IBS-D), 31 patients had a mixture of both diarrhea and constipation (IBS-M), and ...
Dumitrescu Gabriela G Gabriela Dumitrescu, Catalina Mihai, Mihaela Dranga, Cristina Cijevschi Prelipcean, Department of Medical Sciences, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, - - 2014
To describe the relationship between vitamin D levels and inflammatory bowel disease (IBD) characteristics in northeastern Romanian patients. This was a prospective study of 47 consecutive IBD patients admitted to The Institute of Gastroenterology and Hepatology in Iasi, Romania between March 2011 and June 2012. The diagnosis of IBD was ...
Yildiz Abdulmelik A aDepartment of Cardiology, Medical Park Hospital bDepartment of Cardiology, School of Medicine, Istanbul Medipol University, Istanbul cDepartment of Cardiology, School of Medicine, Kafkas University, Kars, - - 2014
It has been shown that increased red blood cell distribution width (RDW) predicts adverse outcomes in cardiovascular disease and in patients undergoing a percutaneous coronary intervention. The aim of the present study was to assess the predictive value of preinterventional RDW on the development of in-stent restenosis (ISR) in patients ...
Ciprandi G - - 2014
Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. Two different studies evidenced that both patients with seasonal AR (SAR) and patients with perennial AR (PAR) had higher sHLA-G levels than normal controls. The aim of this study was to compare ...
Assanasen P - - 2014
Radiofrequency inferior turbinate reduction (RFITR) of inferior turbinate hypertrophy (ITH) is an effective way to treat patients with intractable nasal mucosal obstruction. The objective of this study was to assess smell ability, nasal symptoms, inferior turbinate grading (ITG), peak nasal inspiratory flow (PNIF) of patients with chronic rhinitis (CR), and ...
Goyale Atul A Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, Denmark Hill, London, - - 2014
Refeeding syndrome (RS) is a potentially fatal condition that can occur following the re-introduction of nutrition after a period of starvation. Hypophosphataemia following the reintroduction of nutrition is often the only reliable biochemical marker of RS. Refeeding index (RI) generated from baseline insulin-like growth factor-1 (IGF-1) and leptin has been ...
Moreno Nadia N Servicios de Medicina Digestiva y Radiodiagnóstico, Hospital Universitario Dr. Peset. Valencia, Universidad de Valencia, Spain. Electronic address: - - 2014
The objective of this study was to analyze the accuracy of abdominal ultrasonography (AUS) in the assessment of mucosal healing in patients with Crohn's disease (CD) receiving immunomodulators and/or biological treatment, with ileocolonoscopy as the reference standard. Thirty patients were included in a prospective longitudinal study. All patients underwent ileocolonoscopy ...
Hardy Thomas G TG Royal Victorian Eye and Ear Hospital, Melbourne, - - 2014
To describe the clinical, histopathologic, and radiologic features of a recently identified cause for enlargement of the infraorbital canal. Retrospective, noncomparative case series. Consecutive patients were identified from the orbital databases at Moorfields Eye Hospital, London, England, and the Royal Victorian Eye and Ear Hospital, Melbourne, Australia. A retrospective, noncomparative ...
Kim Tae-Jong TJ Department of Rheumatology, Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, Department of Radiology and Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of - - 2014
Objectives. The aim of this study was to determine whether the presence of peripheral arthritis can affect radiographic structural damage in patients with AS.Methods. A total of 915 subjects comprising 363 patients with a history of peripheral arthritis and 552 patients without a history of peripheral arthritis obtained from the ...
Weingaertner Vera V Department of Palliative Medicine, Clinical Trials Unit (BMBF 01KN1106), and Centre for Integrated Oncology - - 2014
Breathlessness is a distressing symptom in advanced disease. Understanding its patterns, burden and palliative care (PC) needs over time is important to improve patients` quality of life. To describe and compare the courses of refractory breathlessness, functional status, distress and PC needs in patients with advanced chronic obstructive pulmonary disease ...
Sheth Sameer A SA Department of Neurosurgery, Columbia University Medical Center, New York Presbyterian Hospital, New York, New York, - - 2014
To determine the ability of foramen ovale electrodes (FOEs) to localize epileptogenic foci after inconclusive noninvasive investigations in patients with suspected mesial temporal lobe epilepsy (MTLE). We identified patients with medically intractable epilepsy who had undergone FOE investigation for initial invasive monitoring at our institution between 2005 and 2012. Indications ...
Tan X X Department of Ophthalmology, Wuxi No. 2, People's Hospital, Nanjing Medical University, Wuxi, - - 2014
PurposeTo determine the levels of Th17-associated cytokines, particularly interleukin (IL)-17 and IL-22 in tears of patients with dry eye syndrome.MethodsTear samples were collected from 20 healthy volunteers, 20 dry eye (DE) patients with non-Sjögren's syndrome (NSSDE) and 20 DE patients with Sjögren's syndrome (SSDE). Symptom questionnaire was self-administered and multiple ...
Van Cauwenbergh Deborah D Pain in Motion Research Group, Departments of Human Physiology and Rehabilitation Sciences, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Belgium; Pain in Motion Research Group, Faculty of Medicine and Health Sciences, University of Antwerp, - - 2014
It is hypothesized that the autonomic nervous system responds differently to various stressors in patients with chronic fatigue syndrome (CFS) compared to healthy controls. The goal is to systematically review the scientific literature addressing the functioning of the autonomic nervous system in patients with CFS. All studies that were identified ...
Choudhury Supriyo - - 2014
Objectives: Levodopa-induced dyskinesia (LID) is one of the most disabling complications of long-term pharmacotherapy of Parkinson's disease (PD). The objective of our study was to examine the clinical profile and determinants of severity of LID in Indian PD patients on levodopa therapy. Methods: Retrospective analysis of records of PD patients ...
Busse Stefan S Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany, - - 2014
N-methyl-D-aspartate glutamate receptors (NMDA-R) play a key role in learning and memory. Therefore, they may be involved in the pathophysiology of dementia. NMDA-R autoantibodies directed against the NR1a subunit of the NMDA-R, which were first identified as a specific marker for a severe form of encephalitis, cause a decrease in ...
Prinzi Natalie N Department of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico, 155, 00161, Rome, - - 2014
Results from national cancer registries reveal an association of thyroid cancers with extra-thyroidal malignancies. In this study, we evaluated the prevalence of breast cancer (BC) in women affected by both benign and malignant thyroid diseases (TD) in comparison to the general population. To this end, 3,921 female patients from central ...
Xie Yong Y Division of Cardiology, Columbia University Medical Center, New York, New York; Clinical Trials Center, Cardiovascular Research Foundation, New York, New York; Department of Cardiology, Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou, - - 2014
The aim of this study was to report the frequency, patient and lesion-related characteristics, and outcomes of subclinical, nonculprit plaque ruptures in the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study. Plaque rupture and subsequent thrombosis is the most common cause of acute coronary ...
Li Xiao-Lin - - 2014
Red cell distribution width (RDW) has been recognized as a novel marker for several cardiovascular diseases. The aim of this study was to evaluate the association between RDW levels and the presence of isolated coronary artery ectasia (CAE). We studied 414 subjects including 113 patients with isolated CAE (Group A), ...
Agosta Federica F Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, - - 2014
White matter (WM) tract alterations were assessed in patients with progressive supranuclear palsy (PSP) relative to healthy controls and patients with idiopathic Parkinson's disease (PD) to explore the relationship of WM tract damage with clinical disease severity, performance on cognitive tests, and apathy. 37 PSP patients, 41 PD patients, and ...
Okada Takuya T Department of Cardiovascular and Interventional Radiology, Assistance Publique des Hôpitaux de Paris, Georges Pompidou European Hospital, 75015, Paris, France, - - 2014
To classify the renal artery (RA) anatomy based on specific requirements for endovascular renal artery denervation (RDN) in patients with drug-resistant hypertension (RH). The RA anatomy of 122 consecutive RH patients was evaluated by computed tomography angiography and classified as two types: A (main RA ≥20 mm in length and ≥4.0 mm ...
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