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Results 601 - 650 of 14624
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Wang Jing-Houng JH Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2014
Liver stiffness measurement (LSM) using transient elastography is useful in prediction of significant portal hypertension (PHT). To evaluate the usefulness of baseline and serial LSM in predicting clinical disease progression (CDP) for patients with compensated hepatic cirrhosis. Consecutive patients with compensated cirrhosis and without hepatocellular carcinoma (HCC) were prospectively enrolled. ...
Ally Mina S MS Department of Dermatology, Stanford University, Redwood City, - - 2014
IMPORTANCE Keratocystic odontogenic tumors (KCOTs) of the jaw affect more than 65% of patients with basal cell nevus syndrome (BCNS). Surgery frequently causes facial disfigurement and is not always curative. Most BCNS-related and some sporadic KCOTs have malignant activation of the Hedgehog signaling pathway. OBSERVATIONS We examined the effect of ...
Sørensen Camilla Darum CD Department of Haematology, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, - - 2014
The use of locked nucleic acid (LNA) probes and primers potentially improves sensitivity and specificity of quantitative PCR (qPCR) assays. One area of application is that of minimal residual cancer where PCR techniques have proved to be highly relevant tools in patient follow-up. We present here sensitive and specific consensus ...
Vírseda Miguel C MC Department of Urology, Hospital Nacional de Parapléjicos, Toledo, - - 2014
Objective: To analyze whether it is correct to use endoscopic treatment via bulking agents of vesicoureteral reflux (VUR) seen on video urodynamics with non-simultaneous involuntary detrusor contraction in chronic spinal cord injury (SCI) patients with neurogenic detrusor overactivity (NDO). Methods: A retrospective study was performed with a cohort of 76 ...
Demlova Regina R Department of Pharmacology, Masaryk University School of Medicine, Brno, Czech - - 2014
Objective: Individuals with decreased thiopurine methyltransferase (TPMT) activity are at risk of adverse effects of thiopurine administration whereas its increased activity may inactivate drugs faster. We evaluated genotype-phenotype correlations in patients with suspected hematological malignancies and inflammatory bowel disease from our region based on findings of nonlinear TPMT enzyme kinetics ...
Cuperus Frans J C FJ Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, - - 2014
Primary biliary cirrhosis (PBC) can lead to end-stage liver disease and death. Ursodeoxycholic acid (UDCA) treatment can normalize serum liver enzymes in PBC, and such UDCA-responsive patients have a similar life expectancy as age and sex-matched controls. Nearly up to 50% of the patients with PBC, depending on sex and ...
Vitório Rodrigo R UNESP, São Paulo State University at Rio Claro, 1515 24-A Avenue, Rio Claro, São Paulo State 13506-900, Brazil. Electronic address: - - 2014
The current study evaluated the effects of disease severity on the control of obstacle crossing in people with idiopathic Parkinson's disease (PD). Forty-five subjects participated in the study, including 15 patients with mild PD (classified as stage 1 to 1.5 of the Hoehn and Yahr Rating Scale), 15 patients with ...
Pan Jie J JJ Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, - - 2014
In addition to tremor, patients with essential tremor (ET) may exhibit non-motor features, including a range of cognitive deficits. Several prospective, population-based epidemiological studies have reported an association between ET and incident dementia, especially Alzheimer's disease (AD). Moreover, in a brain repository-based study, a larger than expected proportion of ET ...
Lundby-Christensen Louise L Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark; Department of Paediatrics, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark. Electronic address: - - 2014
To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Observational prospective study, 34 obese patients (T2D (n=14)/IGT (n=4), and NGT (n=16)) ...
Danhofer Pavlína P Epilepsy Center Brno, Department of Child Neurology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: - - 2014
The study aim was to evaluate pharmacotherapy effects and long-term seizure outcomes in patients with juvenile absence epilepsy (JAE) during a five-year follow-up period. The secondary aim was to identify factors from patient history and determine their influence on seizure control. We retrospectively studied 46 patients with JAE in the ...
Luo Qun Q Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital, Guangzhou Medical College, Guangzhou, - - 2014
To determine the prevalence of venous thromboembolism (VTE) in patients with connective tissue disease-related interstitial lung diseases (CTD-ILD) and idiopathic interstitial pneumonia (IIP) and to further evaluate associated risk factors. To also examine the diagnostic performance of the Wells score and the revised Geneva scores for diagnosing pulmonary embolism (PE) ...
Aakre Kristin M KM Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, - - 2014
Myocardial infarction (MI) is diagnosed by the finding of a single cardiac troponin value above the 99th percentile and a significant time-dependent change in cardiac troponin concentration. The aim of this study was to determine the 90-min and weekly biological variations, the reference change value (RCV), and the index of ...
Em Serda - - 2014
Moderate joint laxity is widespread in many joints of the body, and this condition is considered to be caused by an abnormality in the collagen structure. This study was carried out to determine the serum prolidase activity in female patients with benign joint hypermobility syndrome (BJHS), and to evaluate its ...
Duplyakov Dmitry D Samara Regional Cardiology Dispensary, Samara, - - 2014
Syncope may develop in 9-35% of patients with pulmonary embolism (PE). Despite its severity and importance, the prognostic value of syncope in PE is unclear. We aimed to assess the value of syncope in patients with high-to-intermediate risk PE. A total of 117 patients (62 males and 55 females, median ...
Cubbon Richard M RM Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Clarendon Way, Leeds, LS2 9JT, - - 2014
Serum calcium (Ca) and inorganic phosphate (Pi) concentrations and calcium-phosphate product (CPP) levels are positively associated with worse outcomes in patients with chronic kidney disease, but there are few data for Pi or Ca and none for CPP in patients with chronic heart failure (CHF). Unselected, consecutive patients with CHF ...
Nyhlin N N Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, - - 2014
Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long-term prognosis is not well described. To study outcome of symptoms and health-related quality of life (HRQoL). A case-control study using a postal questionnaire with three population-based controls per patient matched for ...
Russo Leo L Shire Development LLC, Wayne, PA, USA, - - 2014
Well-designed pharmacoepidemiology studies address several limitations of postmarketing spontaneous reports in regard to signal evaluation. This study evaluated a signal of disproportionate reporting of acute pancreatitis cases observed in patients with ulcerative colitis (UC) treated with MMX Multi Matrix System® (MMX®) mesalazine and demonstrated how inherent limitations of postmarketing reports ...
Niccoli Giampaolo G Cardiovascular Science Department, Sacred Heart University, L.go Gemelli 8, 00168 Rome, - - 2014
Inflammatory reaction after stent implantation is associated with in-stent restenosis (ISR). We assessed the association of optical coherence tomography (OCT) features of neointima with systemic levels of high-sensitivity C-reactive protein (hs-CRP) and eosinophil cationic protein (ECP) measured at the time of ISR detection. Patients presenting with symptomatic angiographically documented ISR ...
Kowalczyk Jacek J Medical University of Silesia, Zabrze, - - 2014
Glucose abnormalities are frequent comorbidities influencing prognosis in patients with cardiovascular diseases. The objective of this study was to evaluate prognostic role of HbA1c in patients with acute myocardial infarction (AMI) treated invasively, who had newly detected glucose abnormalities. Single-centre registry encompassed 2146 survivors of AMI. In all patients without ...
Jenei Zsigmond M ZM 3rd Department of Internal Medicine, Semmelweis University Budapest, - - 2014
Cardiac arrest causes generalized ischemia/hypoxia, and subsequent resuscitation inflicts reperfusion injury, the pathology of which is not fully understood. Moreover, predicting the prognosis of comatose, post-cardiac-arrest patients is a complex clinical challenge. We hypothesized that the extent of complement activation might be a reliable predictor of mortality in this population. ...
van Westrum Steven M Schade SM Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The - - 2014
Objective: To describe the frequency, nature, severity, and progression of cardiac abnormalities in a cohort of Dutch sarcoglycanopathy patients. Methods: In this cross-sectional cohort study, patients were interviewed using a standardized questionnaire and assigned a functional score. Electrocardiograpy (ECG), echocardiography, and 24-hour electrocardiography were performed. Results: 24 patients with sarcoglycanopathy ...
Yamaguchi Shinsaku S Department of Radiology, Kitakyushu General Hospital, Kitakyushu, - - 2014
We evaluated the association between subclinical interstitial lung disease (ILD) and fatal radiation pneumonitis (RP) in patients with thoracic tumors treated with thoracic radiotherapy (RT). Sixty-two consecutive patients with thoracic tumors treated with thoracic RT were retrospectively analyzed. According to our protocols, patients with subclinical ILD (untreated and asymptomatic) were ...
Saleh Hisham Ali HA Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, - - 2014
To study the association between polycystic ovary syndrome (PCOS) and congenital uterine (Müllerian) anomalies in infertile patients. The ultimate aim was to check for a common factor linking both reproductive health problems. A prospective observational study. Tertiary referral infertility center. 3,900 infertile patients were included. The diagnoses of PCOS and ...
Elmelund M M Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, - - 2014
Study design:Retrospective chart review.Objectives:To investigate the role of plasma creatinine (p-creatinine) in monitoring renal deterioration in patients up to 50 years after spinal cord injury (SCI).Setting:The Clinic for Spinal Cord Injuries, Rigshospitalet, Denmark.Methods:A total of 119 patients with a traumatic SCI during the years 1944-1975 were included in the study. ...
Yilmaz Yusuf Y Department of Gastroenterology, Marmara University, School of Medicine , Istanbul , - - 2014
Abstract Objective. Measurements of controlled attenuation parameter (CAP) with transient elastography (FibroScan®; EcoSens SA, Paris, France) may provide an accurate noninvasive assessment of hepatic steatosis. Herein, we prospectively determined the accuracy of liver fat quantification with CAP values in patients with chronic liver diseases and compare the results with those ...
Hegazy Rehab A RA Department of Dermatology, Kasr AlAini Hospital, Cairo University, - - 2014
Narrowband ultraviolet (NB-UV)B is accepted as corner stone therapy for vitiligo. Its influence on the expression of IL-17, IL- 22 and FoxP3 as markers for the Th17 and Tregs lineages has not been studied before in the context of non-segmental vitiligo (NSV). The study included 20 active NSV patients who ...
Zhang Sigong S Department of Rheumatology, China-Japan Friendship Hospital, Beijing, - - 2014
Dermatomyositis (DM) and polymyosits (PM) are systemic autoimmune diseases whose pathogeneses remain unclear. Neutrophil extracellular traps (NETs) are reputed to play an important role in the pathogenesis of autoimmune diseases. This study tests the hypothesis that NETs may be pathogenic in DM/PM. Plasma samples from 97 DM/PM patients (72 DM, ...
Hasegawa T T 1] Department of Physical Therapy, Graduate School of Medicine, Nagoya University, Nagoya, Japan [2] Department of Rehabilitation Medicine, Chubu Rosai Hospital, Nagoya, - - 2014
Study design:Cross-sectional study.Objective:To identify the physical impairments and walking function required for community ambulation in patients with cervical incomplete spinal cord injury (ISCI).Setting:Chubu Rosai Hospital, Nagoya, Japan.Methods:Forty patients with cervical ISCI (mean age: 49.9 years, American Spinal Injury Association Impairment Scale D) were included. The primary outcome measure was community ...
Foulquier Sébastien S aCARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands bKlinik für Innere Medizin III, University Clinic of the Saarland, Homburg/Saar cDepartment of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany dCardiovascular Medicine, John Radcliffe Hospital, Oxford, UK ePopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada fBoehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, - - 2014
In the Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease, all patients were at high cardiovascular risk, and a substantial proportion were hypertensive. We performed a post-hoc analysis to explore the hypothesis that telmisartan has a differential action in hypertensive vs. nonhypertensive patients. The primary four-fold endpoint ...
Jiang Ru-Hong RH Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
PV isolation has become the mainstay acute procedural endpoint for PAF ablation. This study aimed to examine the incidence of conduction recovery in the pulmonary veins (PV) in patients without clinical recurrence of atrial fibrillation (AF) after paroxysmal AF(PAF) ablation. 32 patients without clinical recurrence after PAF ablation underwent electrophysiological ...
Imam Mohamad H MH *Division of Gastroenterology and Hepatology †Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, - - 2014
AIM:: The purpose of this study was to identify the frequency of fat-soluble vitamin deficiencies in children with celiac disease (CD) and to determine the value of routine testing for these deficiencies. We conducted a retrospective medical record review of patients with a confirmed diagnosis of CD and fat-soluble vitamin ...
Hansel Boris B Département d'Endocrinologie, Diabétologie et Nutrition, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France; Institute of Cardiometabolism and Nutrition, Paris, France; Université Paris-Diderot, Paris 7, Paris, France. Electronic address: - - 2014
Phytosterolemia is a rare autosomal recessive disorder characterized by dramatically elevated circulating levels of plant sterols (PS). Phytosterolemia is believed to be responsible for severe premature atherosclerosis. The clinical, biological and molecular genetic features of 5 patients with phytosterolemia and transient severe hypercholesterolemia challenge this hypothesis. Our patients were referred ...
Li Chang-Qing - - 2014
Assessment of inflammatory activity in patients with ulcerative colitis (UC) is crucial to the prediction of relapse. Confocal laser endomicroscopy (CLE) is an accurate tool for assessing inflammatory activity in UC patients. This study aimed to evaluate whether CLE could be used to predict UC relapse reliably. In total, forty-three ...
Zhou S L SL Henan Key Laboratory for Esophageal Cancer Research, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, - - 2014
To evaluate the diagnostic values of using autoantibodies in sera to a panel of eight tumor-associated antigens (TAAs) of P53, Koc, P62, C-myc, IMP1, Survivn, P16 and Cyclin B1 full-length recombinant proteins for early detection of patients with gastric cardia adenocarcinoma (GCA) and high-risk subjects screening. Enzyme-linked immunosorbent assay was ...
Doyle Leona A LA Departments of *Pathology †Medicine, Brigham and Women's Hospital and Harvard Medical School ‡Mastocytosis Center, Brigham and Women's Hospital, Boston, - - 2014
Counting mast cells in gastrointestinal (GI) mucosal biopsies is becoming an increasingly common practice. The primary reason for this exercise is to evaluate for possible involvement by systemic mastocytosis (SM). However, the features of mastocytosis in GI biopsies are not well described. In addition, recent studies have suggested that increased ...
Van Laere Koen K KU Leuven, Nuclear Medicine and Molecular Imaging, University Hospital Leuven, Leuven, Belgium3KU Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium4VIB, - - 2014
IMPORTANCE Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily affecting the motor system, with extramotor involvement to a variable extent. Biomarkers for early differential diagnosis and prognosis are needed. An autosomal dominant hexanucleotide (GGGGCC) expansion in the noncoding region of the chromosome 9 open reading frame 72 (C9orf72) gene ...
Silva Joyce M JM Laboratory of Leishmaniasis, Institute of Tropical Diseases "Natan Portella", Federal University of Piauí, Teresina, PI, Brazil; Department of Biology, Federal University of Piauí, Floriano at Floriano, PI, Brazil; Maternal and Childhood Department, Federal University of Piauí, Teresina, PI, Brazil; Laboratory of Molecular Biology, Nucleus of Tropical Medicine, Federal University of Pará, Belém, PA, Brazil; Department of Community Medicine, Federal University of Piauí, Teresina, PI, - - 2014
Kala-azar or visceral leishmaniasis, found mostly throughout the Indian Subcontinent, East Africa, and Brazil, kills 20,000-40,000 persons annually. The agents, Leishmania donovani and Leishmania infantum, are obligatory intracellular protozoa of mononuclear phagocytes found principally in the spleen and bone marrow. Protracted fever, anemia, wasting, hepatosplenomegaly, hemorrhages, and bacterial co-infections are ...
Higashiyama Yukie Y Faculty of Human Life and Environment, Nara Women's University, Kita-Uoya Nishi-machi, Nara, - - 2014
A nutritional assessment of pediatric patients with cancer is quite important to improve their outcome. However, a longitudinal nutritional study during treatment is still limited. The purpose of this study was to investigate the longitudinal changes in anthropometric measures and serum albumin levels during chemotherapy in patients with acute lymphoblastic ...
Shiono Nobuko N Department of Pediatric Cardiology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka 594-1101, - - 2014
To clarify the outcomes of patients with cardiovascular malformations (CVMs) among those with congenital diaphragmatic hernia (CDH) who are indicated for the Fontan procedure. The study subjects included 76 CDH patients with CVMs recruited from a national survey of 614 CDH patients. The outcomes were evaluated between two groups divided ...
Pan Q Q Department of Infectious Disease, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University, Shanghai, - - 2014
Interleukin-21 (IL-21) participates in tissue damage in various immune-mediated diseases. Its role in the pathogenesis of chronic active hepatitis B (CAHB) has not been clarified. The frequency of circulating IL-21(+) T cells and the levels of serum and intrahepatic IL-21 have been characterized in 70 CAHB patients, 32 inactive carrier ...
Zhang Wen-Ming WM Department of Pediatrics, Renji Hospital Affiliated to Shanghai Jiao-Tong University School of Medcine , Shanghai , - - 2014
Abstract Context: Atopy and systemic onset juvenile idiopathic arthritis (SoJIA) are two potential outcomes of a dysregulated immune system. Although rare, SoJIA causes 60% of the morbidity of JIA patients which exhibit a wide heterogeneity of prognosis and treatment. Co-morbidities can complicate the responses to therapy. Objective: To study the ...
Witting N N Department of Neurology and Neuromuscular Research Unit, University of Copenhagen, Rigshospitalet, Copenhagen, - - 2014
To assess skeletal muscle weakness and progression as well as the cardiopulmonary involvement in oculopharyngeal muscular dystrophy (OPMD). Cross-sectional study including symptomatic patients with genetically confirmed OPMD. Patients were assessed by medical history, ptosis, ophthalmoplegia, facial and limb strength, and swallowing capability. Cardiopulmonary function was evaluated using forced expiratory capacity ...
Falchi Lorenzo L Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United - - 2014
Richter's syndrome (RS) is associated with poor outcome. The prognosis of patients with histologically aggressive chronic lymphocytic leukemia (CLL), HAC, has not been studied. We aimed to correlate 2-Deoxy-2-[(18)F]fluoroglucose/positron emission tomography (FDG/PET) data, histological diagnosis, clinical characteristics and survival in patients with CLL. 332 patients with CLL were histologically classified ...
Olde Rikkert Marcel G M MG Radboud Alzheimer Center, Department of Geriatric Medicine, Radboud University Hospital, Nijmegen, The - - 2014
Background: Studies on the systemic availability of nutrients and nutritional status in Alzheimer's disease (AD) are widely available, but the majority included patients in a moderate stage of AD. Objective: This study compares the nutritional status between mild AD outpatients and healthy controls. Methods: A subgroup of Dutch drug-naïve patients ...
Ladino Lady Diana LD Neurology Department, Hospital Pablo Tobón Uribe, Medellin, Antioquia, - - 2014
The coexistence of focal and generalized epilepsy is rare. We report on a 17-year-old male with drug-resistant focal epilepsy and idiopathic generalized epilepsy (IGE). He began to experience generalized tonic-clonic seizures (GTCS) at the age of 3 years, with a good response to phenobarbital. At the age of 14 years, ...
Christensen Ann Marlene Gram AM From the Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital , Aarhus , - - 2014
Background: The Centor criteria and the streptococcal rapid antigen detection test (RADT) are commonly used to differentiate sore throat patients with group A streptococci (GAS) from patients with other pathogens. We aimed to investigate if procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC), and absolute neutrophil count (ANC) ...
Sakuma Satoru S Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: - - 2014
Pediatric focal epilepsies often involve more extratemporal regions than adult epilepsies. This study aims to investigate the population of oligodendroglia-like cells (OLCs) in the pediatric focal epilepsy patients requiring surgery. We hypothesize that OLCs are one of the factors that extend the pediatric epileptic network in intractable epilepsy. Thirty (18 ...
Bilgin Gorkem - - 2014
Today, identified risk factors for normal-tension glaucoma (NTG) include abnormal ocular blood flow, abnormal blood coagulation, systemic hypotension, ischemic vascular disorders, and autoimmune diseases. However, pathogenesis of the condition remains unclear. On the other hand, there are also a few studies suggesting that the obstructive sleep apnea syndrome (OSAS) may ...
Morris Dominic - - 2014
Diagnosing a specific type of Interstitial Lung Disease (ILD) is a challenging process and often necessitates that a Video-assisted Thoracoscopic Surgery (VATS) Lung Biopsy be performed. By analysing the proportion of patients who have their treatment changed after undergoing a VATS lung biopsy, this study aimed to determine the utility ...
Knopf Andreas A Department of Otorhinolaryngology Head and Neck Surgery, Hals-Nasen-Ohrenklinik und Poliklinik, Technische Universität München, Ismaningerstrasse 22, 81675, Munich, Germany, - - 2014
There are many controversies in head and neck granulomatosis with polyangiitis (HN-GPA). Diagnostic/therapeutic regimens vary due to limited knowledge about the special properties of HN-GPA. 28 patients were diagnosed with GPA accordingly. Anti-neutrophil-cytoplasmatic-antibody (ANCA), anti-peroxidase-antibody (anti-PR3) and biopsies were performed for all patients and set into clinical context. 14 patients ...
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