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Results 601 - 650 of 14713
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Hong J S JS Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Acne and Rosacea Research Laboratory, Seoul National University Hospital, Seoul, - - 2014
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder in women of childbearing-age. Although PCOS has common dermatological manifestations, including hirsutism, acne and androgenetic alopecia, little is known about the dermatological characteristics of PCOS patients in Asia. The goal of this study is to elucidate the dermatological characteristics and metabolic ...
Brambatti Michela M Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Università Politecnica delle Marche, Ancona, - - 2014
Among patients with implantable pacemakers and defibrillators, sub-clinical atrial fibrillation (SCAF) is associated with an increased risk of stroke; however, there is limited understanding of their temporal relationship. The ASSERT trial enrolled 2580 pacemaker and defibrillator patients ≥ 65 years old, with a history of hypertension, but without a history ...
Hu Kuang-Chun KC Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Healthy Evaluation Center, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medicine, Nursing and Management College, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of - - 2014
The role of clinical symptoms, trans-abdominal ultrasound scan (USS), and liver function tests (LFTs) in evaluating common bile duct (CBD) stones in patients suspected to have pancreatobiliary disease has been studied. However, it is unclear whether these predictive models are useful in different age cohorts. To investigate the clinical presentations ...
Vuga Louis J LJ University of Pittsburgh, Medicine, Pittsburgh, Pennsylvania, United States ; - - 2014
Rationale: C-X-C motif chemokine 13 (CXCL13) mediates B-cell trafficking and is increased, proportionately to disease activity, in many antibody-mediated syndromes. Dysregulated B-cells have recently been implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis. Objective: To determine if CXCL13 is associated with IPF progression. Methods: CXCL13 was measured in lungs by DNA ...
Rather Tanveer A TA Department of Nuclear Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, - - 2014
Background: Dyshormonogenetic goiter refers to familial goiters owing to an inherited defect in the metabolism of thyroid hormones. Methods: 19 patients with clinical and biochemically proven hypothyroidism (low T3, FT4 and high TSH) were recruited for the study. All patients were subjected to (i) ultrasound of the neck to rule ...
Aldajani Nader N Department of Otorhinolaryngology, King Abdulaziz Medical City, Riyadh, Saudi Arabia, - - 2014
The objective of this study is to investigate the effects of IDDM on the function of the auditory pathway from the cochlea to the auditory cortex in child patients. Totally, 140 ears of 70 children with IDDM and 60 ears of 30 age and gender-matched healthy controls were included in ...
Ronot Maxime M Department of Radiology, Beaujon University Hospitals Paris Nord Val de Seine, 100 Bd du Général Leclerc, 92110, Clichy, France, - - 2014
To assess the value of the liver and spleen viscoelastic parameters at multifrequency MR elastography to determine the degree of portal hypertension and presence of high-risk oesophageal varices in patients with cirrhosis. From January to September 2012, 36 consecutive patients with cirrhosis evaluated for transplantation were prospectively included. All patients ...
Severens M M Sint Maartenskliniek Nijmegen, Research Department, The Netherlands; Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, The Netherlands. Electronic address: - - 2014
Brain-computer interfaces (BCI) tested in patients often are gaze-dependent, while these intended users could possibly lose the ability to focus their gaze. Therefore, a visual and a tactile gaze-independent spelling system were investigated. Five patients with amyotrophic lateral sclerosis (ALS) tested a visual Hex-o-Spell and a tactile speller. Six healthy ...
Prejbisz Aleksander A Department of Hypertension, Institute of Cardiology, Warsaw, - - 2014
We addressed a question if there is a relationship between severity of newly diagnosed obstructive sleep apnea (OSA) and markers of cardiovascular alterations in middle-aged untreated hypertensive patients. In 121 consecutive patients with never-treated essential hypertension (mean age 35.9±10.1 years; 97 men and 24 women) evaluation of office and ambulatory ...
Kariya S S Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, - - 2014
Background: A close relationship between upper and lower respiratory tract diseases has been reported. However, little is known about pulmonary function in patients with upper respiratory tract diseases. Methods: Pulmonary function was measured in: 68 patients with chronic rhinosinusitis without nasal polyps, 135 patients with chronic rhinosinusitis with nasal polyps, ...
Derks Terry G J TG Section of Metabolic Diseases, University Medical Center Groningen, University of Groningen, 9700, RB, Groningen, The Netherlands, - - 2014
The objective of this study was to test whether macromolecule oxidative damage and altered enzymatic antioxidative defenses occur in patients with medium-chain acyl coenzyme A dehydrogenase (MCAD) deficiency. We performed a cross-sectional observational study of in vivo parameters of lipid and protein oxidative damage and antioxidant defenses in asymptomatic, nonstressed, ...
Vyskocilova Klaudia K 1st Department of Internal Medicine - Cardioangiology, St. Anne's University Hospital in Brno, International Clinical Research Center and Faculty of Medicine, Masaryk University, Brno, Czech - - 2014
Liver pathology caused by cardiac dysfunction is relatively well recognized, however, its clinical importance has not been fully evaluated. The aim of this study was to assess the prevalence of liver function tests (LFTs) abnormalities and to identify associated factors mediating hepatic impairment in patients with acute heart failure (AHF). ...
Matsuda Yayoi Y Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, - - 2014
Surgical treatment of pheochromocytoma is associated with a high risk of hemodynamic instability. To reduce the risk of perioperative complications, adequate medical treatment to normalize blood pressure and restore blood volume is required. Accurate evaluation of the circulating blood volume (CBV) in perioperative patients with pheochromocytoma is clinically important. In ...
Amaro Carmen Regina Petean Ruiz CR Urinary Lithiasis Metabolism Service, Medical School of Botucatu - UNESP, Botucatu, SP, 18618-970, Brazil, - - 2014
The objective of this study was to evaluate the prevalence of urinary metabolic abnormalities in patients with urolithiasis and their potential risk factors. A total of 905 stone patients were evaluated in a prospective trial from February 2000 to January 2012. Inclusion criteria were as follows: history and/or imaging tests ...
Marsovszky László L Department of Ophthalmology, Semmelweis University Budapest, Mária u. 39, 1085, Budapest, Hungary, - - 2014
The recently developed confocal cornea microscopy offers the opportunity to examine pathologies of the cornea and to gain insight into the activity of innate immunity. We aimed to investigate the corneal epithelial and Langerhans cell (LC) densities along with dry eye parameters in primary open-angle glaucoma (POAG) subjects, treated with ...
Thandassery Ragesh Babu RB Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, - - 2014
Hypotension and intestinal mucosal ischemia lead to bacterial translocation from the gut lumen into systemic circulation. The purpose of this study was to determine the strength of association between different types of organ failure (OF): hypotension (cardiovascular system failure), renal failure, respiratory failure, CNS failure and coagulopathy in the first ...
Emad Yasser Y Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt, - - 2014
This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n = 90) were included prospectively and followed up for 1 year, ...
Jin Meiling M State Key Laboratory of Kidney Disease, Institute of Nephrology, Chinese PLA General Hospital, Beijing 100853, China; Medical College, Nankai University, Tianjin 300071, - - 2014
To assess the effectiveness of supine/standing urinalysis for differential diagnosis of left renal vein entrapment syndrome (LRVES) combined with or without glomerulopathy. The enrolled patients with abnormal urinalysis and LRVES demonstrated by Doppler sonography were guided to perform a supine/standing urinalysis. Fifty-two patients were enrolled. Most of them were adolescents ...
Cotter José J Gastroenterology Department, Centro Hospitalar do Alto Ave, Guimarães, Portugal; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, 4710-057 Guimarães, Braga, Portugal. Electronic address: - - 2014
Small bowel capsule endoscopy (SBCE) may detect proximal small bowel lesions that have been previously missed by ileocolonoscopy and small bowel imaging in patients with known ileal and/or colonic Crohn's disease (CD). We aimed to evaluate whether the therapeutic management is influenced by SBCE findings. Retrospective single center study. Inclusion ...
Matsumura Tomoaki T Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Capsule endoscopy (CE) is now widely accepted as a first-line diagnostic modality for obscure gastrointestinal bleeding (OGIB), with a high diagnostic yield compared to other modalities. However, even after negative CE examination, re-bleeding is often known to occur. The aim of the present study was to identify predictive factors of ...
Leclere Lance E LE Department of Orthopaedic Surgery, Naval Medical Center San Diego, San Diego, California, - - 2014
Suprascapular neuropathy is generally considered to be a diagnosis of exclusion, although it has been described in association with several activities and conditions. To our knowledge, this is the first description of suprascapular neuropathy with complete neurogenic fatty replacement in patients with intact rotator cuff tendons in the absence of ...
Pulkkinen Jukka J From the *Department of Surgery, Kuopio University Hospital; †School of Medicine, University of Eastern Finland, Kuopio; ‡Assessment of Pharmacotherapies, Finnish Medicines Agency, Kuopio, Finland; and §Department of Gastroenterology and Alimentary Track Disease, Tampere University Hospital, Tampere, - - 2014
The long-term use of statins may be associated with a decreased risk for gallstones and biliary-induced acute pancreatitis (AP). Our aim was to study the relationship of statin use and outcome of AP. We investigated the records of 461 consecutive patients with AP and 1140 patients with symptomatic gallstones during ...
Alten Tim A TA Department of Radiology, Hannover Medical School, Hannover, - - 2014
Liver biopsy in patients after liver transplantation (OLT) serves as a diagnostic tool to establish the cause of liver pathology. However, liver biopsy may cause life-threatening complications. Very limited information is available about complications and success rates of liver biopsies in patients after OLT. Our aim was to investigate biopsy-related ...
Bhattacharjee Sulagna S *Department of Anaesthesiology & Intensive Care §Department of Anaesthesiology, JPNATC, All India Institute of Medical Sciences †Department of Anaesthesiology, Chacha Nehru Bal Chikitsalaya, New Delhi ‡Department of Critical Care Medicine, Lilavati Hospital & Research Center, Mumbai ∥Department of Anaesthesiology, Institute of Post Graduate Medical Education & Research, Kolkata, - - 2014
Patients of traumatic brain injury (TBI) may have hyperglycemia and when they undergo craniotomy, hyperglycemia may be exacerbated and worsen outcome. However, epidemiology of perioperative hyperglycemia in these patients is unknown. The epidemiological study has been undertaken to address the correlation between intraoperative blood glucose variability in nondiabetic adult TBI ...
Rienstra Michiel M Department of Cardiology, University of Groningen, University Medical Center Groningen, - - 2014
Symptoms are a major driver for patients with atrial fibrillation (AF) to seek medical attention, and are important to titrate AF therapies. However, a large proportion of AF patients are asymptomatic. To investigate the clinical profile and prognosis of patients with asymptomatic recurrent persistent AF in the RACE study. Patients ...
Hooghiemstra Astrid M AM *Department of Clinical Neuropsychology, VU University †Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam ‡Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The - - 2014
A substantial part of elderly persons with dementia show rest-activity rhythm disturbances. The rest-activity rhythm is important to study in people with early-onset dementia (EOD) for rest-activity rhythm disturbances are predictive of institutionalization, and caregivers of young patients suffer from high distress. The aim of this study was to study ...
Rofes L L Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, - - 2014
Increasing bolus viscosity of thin liquids is a basic therapeutic strategy to protect patients with oropharyngeal dysphagia (OD) from aspiration. However, conventional starch thickeners increase post-deglutitive residue. To assess the therapeutic effect of a new xanthan gum-based thickener, Resource ThickenUp Clear (Nestlé Health Science, Vevey, Switzerland) on patients with oropharyngeal ...
Kurultak Ilhan I Department of Nephrology, School of Medicine, Ankara University , Ankara , - - 2014
Abstract Background: Although several lines of evidence suggest that renin angiotensin system (RAS) proteins are synthesized by cyst epithelium and dilated tubules, role of intrarenal RAS in the progression of otozomal dominant polycystic kidney disease (ADPKD) is not well known. We aimed to study the levels and clinical correlations of ...
Alhamad Hanadi Khamis HK Al-Rumailah hospital, Hamad Medical Corporation , Doha , - - 2014
Abstract Objectives: Vitamin D (VitD) deficiency is associated with comorbidities in the elderly. The present study investigates the prevalence of VitD deficiency among the elderly in Qatar. Research design and methods: A retrospective study conducted between April 2010 and April 2012 that involved chart reviews. All elderly patients of age ...
Viticchi Giovanna G Neurological Clinic, Marche Polytechnic University, Ancona, - - 2014
The presence of apolipoprotein E (APOE) ε4 allele is the only recognized genetic risk factor for the sporadic form of Alzheimer's disease. The aim of this study was to investigate the relationship between APOE genotype and the functional and anatomic status of cerebral vessels in patients with mild cognitive impairment ...
Manenschijn L L Department of Internal Medicine, Erasmus MC, Rotterdam, The - - 2014
The only approved drug for the treatment of adrenocortical cancer (ACC) is mitotane. Mitotane is adrenolytic and therefore, hydrocortisone replacement therapy is necessary. Since mitotane increases cortisol binding globulin (CBG) and induces CYP3A4 activity, high doses of hydrocortisone are thought to be required. Evaluation of hydrocortisone therapy in mitotane-treated patients ...
De Bernardi Bruno B Department of Hematology-Oncology, Istituto Giannina Gaslini, Genova, - - 2014
Symptoms of epidural compression (SEC) in children with neuroblastoma (particularly infants) may be misinterpreted, leading to delay in diagnosis. Clinical, imaging and follow-up data of 34 infants with neuroblastoma and SEC diagnosed between 2000 and 2011 at Italian AIEOP centers were retrieved and reviewed. Median age at initial SEC was ...
Abraham Bincy P BP Houston Methodist, 6550 Fannin St. Smith Tower, Suite 1001, Houston, TX, 77030, USA, - - 2014
As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. Demographic data including ...
Hagenaars J C J P JC Department of Surgery, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands, - - 2014
The aim of this study was to provide data on the risk of developing chronic Q fever in patients with aorto-iliac disease and evidence of previous Q fever infection. Patients with an aortic and/or iliac aneurysm or aorto-iliac reconstruction (aorto-iliac disease) and evidence of previous Q fever infection were included. ...
Zhang Yun Y Department of Head and Neck Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, - - 2014
Hashimoto's thyroiditis (HT) is the most common type of autoimmune thyroid disease, and the incidence is rising in recent years. The aim of this study was to evaluate the pathological characteristics, treatment and prognosis of HT with papillary thyroid carcinoma (PTC). From July 2004 to December 2011, 8,524 patients underwent ...
Huppertz Alexander A Department of Radiology, Charité - University Hospitals, Charitéplatz 1, 10117, Berlin, Germany, - - 2014
Objective of the study is to compare the diagnostic accuracy for detecting monosodium urate crystal deposits between dual-energy CT (DECT) and ultrasound (US). Sixty consecutive patients (49 men, mean age 62 years) with clinically suspected gout were included in this case-control study. DECT and US of feet, knees, hands and elbows ...
Nobre Carla C Internal Medicine Service, Centro Hospitalar Barreiro-Montijo, EPE , Lisbon , - - 2014
Introduction: There is considerable debate regarding the use of thrombolytic therapy in patients with pulmonary embolism, normal blood pressure and intermediate clinical risk, as defined by right ventricular dysfunction on transthoracic echocardiography or elevated serum markers of cardiac necrosis. Aims and objectives: A clinical audit of normotensive patients diagnosed with ...
Londoño Diana D Massachusetts General Hospital and Harvard Medical School, Boston, - - 2014
Objective. Endothelial cell growth factor (ECGF) was recently identified as the first autoantigen known to be a target of T and B cell responses in about 20% of patients with antibiotic-refractory Lyme arthritis. The goal of the current study was to look for a pathologic correlate between ECGF autoantibody responses ...
Río Jordi J Centre d'esclerosi múltiple de Catalunya (CEM-Cat), Servei de Neurologia-Neuroimmunologia, Hospital Universitario Vall d'Hebron, Barcelona, - - 2014
In patients with relapsing-remitting multiple sclerosis (RRMS), a scoring system based on new magnetic resonance imaging (MRI) active lesions, relapses and sustained disability progression after a 1-year treatment with IFNβ predicted patient disability progression over time; however, this score had not been tested in patients receiving glatiramer acetate (GA). The ...
van Duinkerken Eelco - - 2014
Type 1 diabetes mellitus (T1DM) is associated with cerebral compromise, typically found in patients with microangiopathy. Associations between subclinical macroangiopathy and the brain, whether or not in the presence of microangiopathy, have not been fully explored in T1DM. We hypothesized that subclinical macroangiopathy in adult T1DM may affect the brain ...
Wang Jing-Houng JH Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2014
Liver stiffness measurement (LSM) using transient elastography is useful in prediction of significant portal hypertension (PHT). To evaluate the usefulness of baseline and serial LSM in predicting clinical disease progression (CDP) for patients with compensated hepatic cirrhosis. Consecutive patients with compensated cirrhosis and without hepatocellular carcinoma (HCC) were prospectively enrolled. ...
Ally Mina S MS Department of Dermatology, Stanford University, Redwood City, - - 2014
IMPORTANCE Keratocystic odontogenic tumors (KCOTs) of the jaw affect more than 65% of patients with basal cell nevus syndrome (BCNS). Surgery frequently causes facial disfigurement and is not always curative. Most BCNS-related and some sporadic KCOTs have malignant activation of the Hedgehog signaling pathway. OBSERVATIONS We examined the effect of ...
Sørensen Camilla Darum CD Department of Haematology, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, - - 2014
The use of locked nucleic acid (LNA) probes and primers potentially improves sensitivity and specificity of quantitative PCR (qPCR) assays. One area of application is that of minimal residual cancer where PCR techniques have proved to be highly relevant tools in patient follow-up. We present here sensitive and specific consensus ...
Vírseda Miguel C MC Department of Urology, Hospital Nacional de Parapléjicos, Toledo, - - 2014
Objective: To analyze whether it is correct to use endoscopic treatment via bulking agents of vesicoureteral reflux (VUR) seen on video urodynamics with non-simultaneous involuntary detrusor contraction in chronic spinal cord injury (SCI) patients with neurogenic detrusor overactivity (NDO). Methods: A retrospective study was performed with a cohort of 76 ...
Demlova Regina R Department of Pharmacology, Masaryk University School of Medicine, Brno, Czech - - 2014
Objective: Individuals with decreased thiopurine methyltransferase (TPMT) activity are at risk of adverse effects of thiopurine administration whereas its increased activity may inactivate drugs faster. We evaluated genotype-phenotype correlations in patients with suspected hematological malignancies and inflammatory bowel disease from our region based on findings of nonlinear TPMT enzyme kinetics ...
Cuperus Frans J C FJ Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, - - 2014
Primary biliary cirrhosis (PBC) can lead to end-stage liver disease and death. Ursodeoxycholic acid (UDCA) treatment can normalize serum liver enzymes in PBC, and such UDCA-responsive patients have a similar life expectancy as age and sex-matched controls. Nearly up to 50% of the patients with PBC, depending on sex and ...
Vitório Rodrigo R UNESP, São Paulo State University at Rio Claro, 1515 24-A Avenue, Rio Claro, São Paulo State 13506-900, Brazil. Electronic address: - - 2014
The current study evaluated the effects of disease severity on the control of obstacle crossing in people with idiopathic Parkinson's disease (PD). Forty-five subjects participated in the study, including 15 patients with mild PD (classified as stage 1 to 1.5 of the Hoehn and Yahr Rating Scale), 15 patients with ...
Pan Jie J JJ Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, - - 2014
In addition to tremor, patients with essential tremor (ET) may exhibit non-motor features, including a range of cognitive deficits. Several prospective, population-based epidemiological studies have reported an association between ET and incident dementia, especially Alzheimer's disease (AD). Moreover, in a brain repository-based study, a larger than expected proportion of ET ...
Lundby-Christensen Louise L Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark; Department of Paediatrics, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark. Electronic address: - - 2014
To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Observational prospective study, 34 obese patients (T2D (n=14)/IGT (n=4), and NGT (n=16)) ...
Danhofer Pavlína P Epilepsy Center Brno, Department of Child Neurology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: - - 2014
The study aim was to evaluate pharmacotherapy effects and long-term seizure outcomes in patients with juvenile absence epilepsy (JAE) during a five-year follow-up period. The secondary aim was to identify factors from patient history and determine their influence on seizure control. We retrospectively studied 46 patients with JAE in the ...
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