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Matsumura Tomoaki T Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Capsule endoscopy (CE) is now widely accepted as a first-line diagnostic modality for obscure gastrointestinal bleeding (OGIB), with a high diagnostic yield compared to other modalities. However, even after negative CE examination, re-bleeding is often known to occur. The aim of the present study was to identify predictive factors of ...
Leclere Lance E LE Department of Orthopaedic Surgery, Naval Medical Center San Diego, San Diego, California, - - 2014
Suprascapular neuropathy is generally considered to be a diagnosis of exclusion, although it has been described in association with several activities and conditions. To our knowledge, this is the first description of suprascapular neuropathy with complete neurogenic fatty replacement in patients with intact rotator cuff tendons in the absence of ...
Pulkkinen Jukka J From the *Department of Surgery, Kuopio University Hospital; †School of Medicine, University of Eastern Finland, Kuopio; ‡Assessment of Pharmacotherapies, Finnish Medicines Agency, Kuopio, Finland; and §Department of Gastroenterology and Alimentary Track Disease, Tampere University Hospital, Tampere, - - 2014
The long-term use of statins may be associated with a decreased risk for gallstones and biliary-induced acute pancreatitis (AP). Our aim was to study the relationship of statin use and outcome of AP. We investigated the records of 461 consecutive patients with AP and 1140 patients with symptomatic gallstones during ...
Alten Tim A TA Department of Radiology, Hannover Medical School, Hannover, - - 2014
Liver biopsy in patients after liver transplantation (OLT) serves as a diagnostic tool to establish the cause of liver pathology. However, liver biopsy may cause life-threatening complications. Very limited information is available about complications and success rates of liver biopsies in patients after OLT. Our aim was to investigate biopsy-related ...
Bhattacharjee Sulagna S *Department of Anaesthesiology & Intensive Care §Department of Anaesthesiology, JPNATC, All India Institute of Medical Sciences †Department of Anaesthesiology, Chacha Nehru Bal Chikitsalaya, New Delhi ‡Department of Critical Care Medicine, Lilavati Hospital & Research Center, Mumbai ∥Department of Anaesthesiology, Institute of Post Graduate Medical Education & Research, Kolkata, - - 2014
Patients of traumatic brain injury (TBI) may have hyperglycemia and when they undergo craniotomy, hyperglycemia may be exacerbated and worsen outcome. However, epidemiology of perioperative hyperglycemia in these patients is unknown. The epidemiological study has been undertaken to address the correlation between intraoperative blood glucose variability in nondiabetic adult TBI ...
Rienstra Michiel M Department of Cardiology, University of Groningen, University Medical Center Groningen, - - 2014
Symptoms are a major driver for patients with atrial fibrillation (AF) to seek medical attention, and are important to titrate AF therapies. However, a large proportion of AF patients are asymptomatic. To investigate the clinical profile and prognosis of patients with asymptomatic recurrent persistent AF in the RACE study. Patients ...
Hooghiemstra Astrid M AM *Department of Clinical Neuropsychology, VU University †Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam ‡Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The - - 2014
A substantial part of elderly persons with dementia show rest-activity rhythm disturbances. The rest-activity rhythm is important to study in people with early-onset dementia (EOD) for rest-activity rhythm disturbances are predictive of institutionalization, and caregivers of young patients suffer from high distress. The aim of this study was to study ...
Rofes L L Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, - - 2014
Increasing bolus viscosity of thin liquids is a basic therapeutic strategy to protect patients with oropharyngeal dysphagia (OD) from aspiration. However, conventional starch thickeners increase post-deglutitive residue. To assess the therapeutic effect of a new xanthan gum-based thickener, Resource ThickenUp Clear (Nestlé Health Science, Vevey, Switzerland) on patients with oropharyngeal ...
Kurultak Ilhan I Department of Nephrology, School of Medicine, Ankara University , Ankara , - - 2014
Abstract Background: Although several lines of evidence suggest that renin angiotensin system (RAS) proteins are synthesized by cyst epithelium and dilated tubules, role of intrarenal RAS in the progression of otozomal dominant polycystic kidney disease (ADPKD) is not well known. We aimed to study the levels and clinical correlations of ...
Alhamad Hanadi Khamis HK Al-Rumailah hospital, Hamad Medical Corporation , Doha , - - 2014
Abstract Objectives: Vitamin D (VitD) deficiency is associated with comorbidities in the elderly. The present study investigates the prevalence of VitD deficiency among the elderly in Qatar. Research design and methods: A retrospective study conducted between April 2010 and April 2012 that involved chart reviews. All elderly patients of age ...
Viticchi Giovanna G Neurological Clinic, Marche Polytechnic University, Ancona, - - 2014
The presence of apolipoprotein E (APOE) ε4 allele is the only recognized genetic risk factor for the sporadic form of Alzheimer's disease. The aim of this study was to investigate the relationship between APOE genotype and the functional and anatomic status of cerebral vessels in patients with mild cognitive impairment ...
Manenschijn L L Department of Internal Medicine, Erasmus MC, Rotterdam, The - - 2014
The only approved drug for the treatment of adrenocortical cancer (ACC) is mitotane. Mitotane is adrenolytic and therefore, hydrocortisone replacement therapy is necessary. Since mitotane increases cortisol binding globulin (CBG) and induces CYP3A4 activity, high doses of hydrocortisone are thought to be required. Evaluation of hydrocortisone therapy in mitotane-treated patients ...
De Bernardi Bruno B Department of Hematology-Oncology, Istituto Giannina Gaslini, Genova, - - 2014
Symptoms of epidural compression (SEC) in children with neuroblastoma (particularly infants) may be misinterpreted, leading to delay in diagnosis. Clinical, imaging and follow-up data of 34 infants with neuroblastoma and SEC diagnosed between 2000 and 2011 at Italian AIEOP centers were retrieved and reviewed. Median age at initial SEC was ...
Abraham Bincy P BP Houston Methodist, 6550 Fannin St. Smith Tower, Suite 1001, Houston, TX, 77030, USA, - - 2014
As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. Demographic data including ...
Hagenaars J C J P JC Department of Surgery, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands, - - 2014
The aim of this study was to provide data on the risk of developing chronic Q fever in patients with aorto-iliac disease and evidence of previous Q fever infection. Patients with an aortic and/or iliac aneurysm or aorto-iliac reconstruction (aorto-iliac disease) and evidence of previous Q fever infection were included. ...
Zhang Yun Y Department of Head and Neck Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, - - 2014
Hashimoto's thyroiditis (HT) is the most common type of autoimmune thyroid disease, and the incidence is rising in recent years. The aim of this study was to evaluate the pathological characteristics, treatment and prognosis of HT with papillary thyroid carcinoma (PTC). From July 2004 to December 2011, 8,524 patients underwent ...
Huppertz Alexander A Department of Radiology, Charité - University Hospitals, Charitéplatz 1, 10117, Berlin, Germany, - - 2014
Objective of the study is to compare the diagnostic accuracy for detecting monosodium urate crystal deposits between dual-energy CT (DECT) and ultrasound (US). Sixty consecutive patients (49 men, mean age 62 years) with clinically suspected gout were included in this case-control study. DECT and US of feet, knees, hands and elbows ...
Nobre Carla C Internal Medicine Service, Centro Hospitalar Barreiro-Montijo, EPE , Lisbon , - - 2014
Introduction: There is considerable debate regarding the use of thrombolytic therapy in patients with pulmonary embolism, normal blood pressure and intermediate clinical risk, as defined by right ventricular dysfunction on transthoracic echocardiography or elevated serum markers of cardiac necrosis. Aims and objectives: A clinical audit of normotensive patients diagnosed with ...
Londoño Diana D Massachusetts General Hospital and Harvard Medical School, Boston, - - 2014
Objective. Endothelial cell growth factor (ECGF) was recently identified as the first autoantigen known to be a target of T and B cell responses in about 20% of patients with antibiotic-refractory Lyme arthritis. The goal of the current study was to look for a pathologic correlate between ECGF autoantibody responses ...
Río Jordi J Centre d'esclerosi múltiple de Catalunya (CEM-Cat), Servei de Neurologia-Neuroimmunologia, Hospital Universitario Vall d'Hebron, Barcelona, - - 2014
In patients with relapsing-remitting multiple sclerosis (RRMS), a scoring system based on new magnetic resonance imaging (MRI) active lesions, relapses and sustained disability progression after a 1-year treatment with IFNβ predicted patient disability progression over time; however, this score had not been tested in patients receiving glatiramer acetate (GA). The ...
van Duinkerken Eelco - - 2014
Type 1 diabetes mellitus (T1DM) is associated with cerebral compromise, typically found in patients with microangiopathy. Associations between subclinical macroangiopathy and the brain, whether or not in the presence of microangiopathy, have not been fully explored in T1DM. We hypothesized that subclinical macroangiopathy in adult T1DM may affect the brain ...
Wang Jing-Houng JH Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, - - 2014
Liver stiffness measurement (LSM) using transient elastography is useful in prediction of significant portal hypertension (PHT). To evaluate the usefulness of baseline and serial LSM in predicting clinical disease progression (CDP) for patients with compensated hepatic cirrhosis. Consecutive patients with compensated cirrhosis and without hepatocellular carcinoma (HCC) were prospectively enrolled. ...
Ally Mina S MS Department of Dermatology, Stanford University, Redwood City, - - 2014
IMPORTANCE Keratocystic odontogenic tumors (KCOTs) of the jaw affect more than 65% of patients with basal cell nevus syndrome (BCNS). Surgery frequently causes facial disfigurement and is not always curative. Most BCNS-related and some sporadic KCOTs have malignant activation of the Hedgehog signaling pathway. OBSERVATIONS We examined the effect of ...
Sørensen Camilla Darum CD Department of Haematology, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, - - 2014
The use of locked nucleic acid (LNA) probes and primers potentially improves sensitivity and specificity of quantitative PCR (qPCR) assays. One area of application is that of minimal residual cancer where PCR techniques have proved to be highly relevant tools in patient follow-up. We present here sensitive and specific consensus ...
Vírseda Miguel C MC Department of Urology, Hospital Nacional de Parapléjicos, Toledo, - - 2014
Objective: To analyze whether it is correct to use endoscopic treatment via bulking agents of vesicoureteral reflux (VUR) seen on video urodynamics with non-simultaneous involuntary detrusor contraction in chronic spinal cord injury (SCI) patients with neurogenic detrusor overactivity (NDO). Methods: A retrospective study was performed with a cohort of 76 ...
Demlova Regina R Department of Pharmacology, Masaryk University School of Medicine, Brno, Czech - - 2014
Objective: Individuals with decreased thiopurine methyltransferase (TPMT) activity are at risk of adverse effects of thiopurine administration whereas its increased activity may inactivate drugs faster. We evaluated genotype-phenotype correlations in patients with suspected hematological malignancies and inflammatory bowel disease from our region based on findings of nonlinear TPMT enzyme kinetics ...
Cuperus Frans J C FJ Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, - - 2014
Primary biliary cirrhosis (PBC) can lead to end-stage liver disease and death. Ursodeoxycholic acid (UDCA) treatment can normalize serum liver enzymes in PBC, and such UDCA-responsive patients have a similar life expectancy as age and sex-matched controls. Nearly up to 50% of the patients with PBC, depending on sex and ...
Vitório Rodrigo R UNESP, São Paulo State University at Rio Claro, 1515 24-A Avenue, Rio Claro, São Paulo State 13506-900, Brazil. Electronic address: - - 2014
The current study evaluated the effects of disease severity on the control of obstacle crossing in people with idiopathic Parkinson's disease (PD). Forty-five subjects participated in the study, including 15 patients with mild PD (classified as stage 1 to 1.5 of the Hoehn and Yahr Rating Scale), 15 patients with ...
Pan Jie J JJ Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, - - 2014
In addition to tremor, patients with essential tremor (ET) may exhibit non-motor features, including a range of cognitive deficits. Several prospective, population-based epidemiological studies have reported an association between ET and incident dementia, especially Alzheimer's disease (AD). Moreover, in a brain repository-based study, a larger than expected proportion of ET ...
Lundby-Christensen Louise L Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark; Department of Paediatrics, Copenhagen University Hospital Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark. Electronic address: - - 2014
To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Observational prospective study, 34 obese patients (T2D (n=14)/IGT (n=4), and NGT (n=16)) ...
Danhofer Pavlína P Epilepsy Center Brno, Department of Child Neurology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: - - 2014
The study aim was to evaluate pharmacotherapy effects and long-term seizure outcomes in patients with juvenile absence epilepsy (JAE) during a five-year follow-up period. The secondary aim was to identify factors from patient history and determine their influence on seizure control. We retrospectively studied 46 patients with JAE in the ...
Luo Qun Q Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital, Guangzhou Medical College, Guangzhou, - - 2014
To determine the prevalence of venous thromboembolism (VTE) in patients with connective tissue disease-related interstitial lung diseases (CTD-ILD) and idiopathic interstitial pneumonia (IIP) and to further evaluate associated risk factors. To also examine the diagnostic performance of the Wells score and the revised Geneva scores for diagnosing pulmonary embolism (PE) ...
Aakre Kristin M KM Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, - - 2014
Myocardial infarction (MI) is diagnosed by the finding of a single cardiac troponin value above the 99th percentile and a significant time-dependent change in cardiac troponin concentration. The aim of this study was to determine the 90-min and weekly biological variations, the reference change value (RCV), and the index of ...
Em Serda - - 2014
Moderate joint laxity is widespread in many joints of the body, and this condition is considered to be caused by an abnormality in the collagen structure. This study was carried out to determine the serum prolidase activity in female patients with benign joint hypermobility syndrome (BJHS), and to evaluate its ...
Duplyakov Dmitry D Samara Regional Cardiology Dispensary, Samara, - - 2014
Syncope may develop in 9-35% of patients with pulmonary embolism (PE). Despite its severity and importance, the prognostic value of syncope in PE is unclear. We aimed to assess the value of syncope in patients with high-to-intermediate risk PE. A total of 117 patients (62 males and 55 females, median ...
Cubbon Richard M RM Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Clarendon Way, Leeds, LS2 9JT, - - 2014
Serum calcium (Ca) and inorganic phosphate (Pi) concentrations and calcium-phosphate product (CPP) levels are positively associated with worse outcomes in patients with chronic kidney disease, but there are few data for Pi or Ca and none for CPP in patients with chronic heart failure (CHF). Unselected, consecutive patients with CHF ...
Nyhlin N N Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, - - 2014
Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long-term prognosis is not well described. To study outcome of symptoms and health-related quality of life (HRQoL). A case-control study using a postal questionnaire with three population-based controls per patient matched for ...
Russo Leo L Shire Development LLC, Wayne, PA, USA, - - 2014
Well-designed pharmacoepidemiology studies address several limitations of postmarketing spontaneous reports in regard to signal evaluation. This study evaluated a signal of disproportionate reporting of acute pancreatitis cases observed in patients with ulcerative colitis (UC) treated with MMX Multi Matrix System® (MMX®) mesalazine and demonstrated how inherent limitations of postmarketing reports ...
Niccoli Giampaolo G Cardiovascular Science Department, Sacred Heart University, L.go Gemelli 8, 00168 Rome, - - 2014
Inflammatory reaction after stent implantation is associated with in-stent restenosis (ISR). We assessed the association of optical coherence tomography (OCT) features of neointima with systemic levels of high-sensitivity C-reactive protein (hs-CRP) and eosinophil cationic protein (ECP) measured at the time of ISR detection. Patients presenting with symptomatic angiographically documented ISR ...
Kowalczyk Jacek J Medical University of Silesia, Zabrze, - - 2014
Glucose abnormalities are frequent comorbidities influencing prognosis in patients with cardiovascular diseases. The objective of this study was to evaluate prognostic role of HbA1c in patients with acute myocardial infarction (AMI) treated invasively, who had newly detected glucose abnormalities. Single-centre registry encompassed 2146 survivors of AMI. In all patients without ...
Jenei Zsigmond M ZM 3rd Department of Internal Medicine, Semmelweis University Budapest, - - 2014
Cardiac arrest causes generalized ischemia/hypoxia, and subsequent resuscitation inflicts reperfusion injury, the pathology of which is not fully understood. Moreover, predicting the prognosis of comatose, post-cardiac-arrest patients is a complex clinical challenge. We hypothesized that the extent of complement activation might be a reliable predictor of mortality in this population. ...
van Westrum Steven M Schade SM Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The - - 2014
Objective: To describe the frequency, nature, severity, and progression of cardiac abnormalities in a cohort of Dutch sarcoglycanopathy patients. Methods: In this cross-sectional cohort study, patients were interviewed using a standardized questionnaire and assigned a functional score. Electrocardiograpy (ECG), echocardiography, and 24-hour electrocardiography were performed. Results: 24 patients with sarcoglycanopathy ...
Yamaguchi Shinsaku S Department of Radiology, Kitakyushu General Hospital, Kitakyushu, - - 2014
We evaluated the association between subclinical interstitial lung disease (ILD) and fatal radiation pneumonitis (RP) in patients with thoracic tumors treated with thoracic radiotherapy (RT). Sixty-two consecutive patients with thoracic tumors treated with thoracic RT were retrospectively analyzed. According to our protocols, patients with subclinical ILD (untreated and asymptomatic) were ...
Saleh Hisham Ali HA Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, - - 2014
To study the association between polycystic ovary syndrome (PCOS) and congenital uterine (Müllerian) anomalies in infertile patients. The ultimate aim was to check for a common factor linking both reproductive health problems. A prospective observational study. Tertiary referral infertility center. 3,900 infertile patients were included. The diagnoses of PCOS and ...
Elmelund M M Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, - - 2014
Study design:Retrospective chart review.Objectives:To investigate the role of plasma creatinine (p-creatinine) in monitoring renal deterioration in patients up to 50 years after spinal cord injury (SCI).Setting:The Clinic for Spinal Cord Injuries, Rigshospitalet, Denmark.Methods:A total of 119 patients with a traumatic SCI during the years 1944-1975 were included in the study. ...
Yilmaz Yusuf Y Department of Gastroenterology, Marmara University, School of Medicine , Istanbul , - - 2014
Abstract Objective. Measurements of controlled attenuation parameter (CAP) with transient elastography (FibroScan®; EcoSens SA, Paris, France) may provide an accurate noninvasive assessment of hepatic steatosis. Herein, we prospectively determined the accuracy of liver fat quantification with CAP values in patients with chronic liver diseases and compare the results with those ...
Hegazy Rehab A RA Department of Dermatology, Kasr AlAini Hospital, Cairo University, - - 2014
Narrowband ultraviolet (NB-UV)B is accepted as corner stone therapy for vitiligo. Its influence on the expression of IL-17, IL- 22 and FoxP3 as markers for the Th17 and Tregs lineages has not been studied before in the context of non-segmental vitiligo (NSV). The study included 20 active NSV patients who ...
Zhang Sigong S Department of Rheumatology, China-Japan Friendship Hospital, Beijing, - - 2014
Dermatomyositis (DM) and polymyosits (PM) are systemic autoimmune diseases whose pathogeneses remain unclear. Neutrophil extracellular traps (NETs) are reputed to play an important role in the pathogenesis of autoimmune diseases. This study tests the hypothesis that NETs may be pathogenic in DM/PM. Plasma samples from 97 DM/PM patients (72 DM, ...
Hasegawa T T 1] Department of Physical Therapy, Graduate School of Medicine, Nagoya University, Nagoya, Japan [2] Department of Rehabilitation Medicine, Chubu Rosai Hospital, Nagoya, - - 2014
Study design:Cross-sectional study.Objective:To identify the physical impairments and walking function required for community ambulation in patients with cervical incomplete spinal cord injury (ISCI).Setting:Chubu Rosai Hospital, Nagoya, Japan.Methods:Forty patients with cervical ISCI (mean age: 49.9 years, American Spinal Injury Association Impairment Scale D) were included. The primary outcome measure was community ...
Foulquier Sébastien S aCARIM, School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands bKlinik für Innere Medizin III, University Clinic of the Saarland, Homburg/Saar cDepartment of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany dCardiovascular Medicine, John Radcliffe Hospital, Oxford, UK ePopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada fBoehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, - - 2014
In the Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease, all patients were at high cardiovascular risk, and a substantial proportion were hypertensive. We performed a post-hoc analysis to explore the hypothesis that telmisartan has a differential action in hypertensive vs. nonhypertensive patients. The primary four-fold endpoint ...
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