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Results 451 - 500 of 18173
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Wachtel Heather H Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA, - - 2014
Pheochromocytomas are rare neuroendocrine tumors. With the widespread use of cross-sectional imaging, increasing numbers are identified incidentally, but their clinicopathologic traits have been incompletely characterized. We performed a retrospective cohort study of patients who underwent initial adrenalectomy for pheochromocytoma (1997-2014). Patients were classified as identified by guided investigation (GIP) if ...
Kim Dae-Hee DH Cardiac Imaging Center, Asan Medical Center Heart Institute, University of Ulsan College of Medicine, Seoul, South - - 2014
-The three-dimensional (3D) relationship between aortic root and cusp are essential to understand the mechanism of aortic regurgitation (AR) due to aortic root dilatation (ARD). We sought to test the hypothesis that the stretched cusps in ARD enlarge to compensate for ARD. -Computed tomography imaged 92 patients, 57 with ARD: ...
Fritz S S Departments of General, Visceral and Transplantation - - 2014
Autoimmune pancreatitis (AIP) is characterized by diffuse or focal swelling of the pancreas. AIP has been divided into types 1 and 2. The aim of the study was to evaluate and compare the clinicopathological characteristics, therapy and outcome of patients with AIP. The medical records of patients diagnosed with AIP ...
Yamamoto Yoshiaki Y Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886, Urushiyama, Shizuoka, 420-8688, Japan, - - 2014
The aim of this study was to evaluate the effect of cytochrome P450 (CYP) inducers/inhibitors on the pharmacokinetics of clobazam (CLB) in patients receiving antiepileptic polypharmacy. A total of 2,504 samples obtained from 1,280 patients for routine therapeutic drug monitoring were retrospectively reviewed. These samples were grouped according to the ...
Zenda Takahiro T Department of Internal Medicine, Hokuriku Central Hospital of Japan Mutual Aid Association of Public School Teachers , Toyama , - - 2014
Abstract Objective. The pathogenetic relationship underlying the high prevalence of gastroesophageal reflux disease (GERD) in patients with obstructive sleep apnea (OSA) remains unclear. In addition, GERD has not been adequately assessed by endoscopy in patients with OSA. The purpose of this study was to use endoscopy to investigate potential interactions ...
Freud Lindsay R LR Boston Children's Hospital, Boston, MA - - 2014
-Fetal aortic valvuloplasty (FAV) can be performed for severe mid-gestation aortic stenosis (AS) in an attempt to prevent progression to hypoplastic left heart syndrome (HLHS). A subset of patients has achieved a biventricular (BV) circulation after FAV. The postnatal outcomes and survival of the BV patients, compared to those managed ...
te Riele Anneline S J M AS Department of Medicine, Division of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, - - 2014
Incomplete penetrance and variable expressivity of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) complicate family screening. The objective of the present study was to determine the optimal approach to longitudinal follow-up regarding: 1) screening interval; and 2) testing strategy in at-risk relatives of ARVD/C patients. We included 117 relatives (45% male, age ...
Takahashi Hiroshi H Department of Orthopaedic Surgery, Toho University Sakura Medical Center, 564-1, Shimoshizu, Sakura City, Chiba 285-8741, Japan. Electronic address: - - 2014
It is known that the severity of compression myelopathy sometimes worsens rapidly and results in poor functional recovery because of limited axonal regeneration. Levels of phosphorylated neurofilament subunit NF-H (pNF-H), which indicate axonal degeneration, are elevated in other neurological disorders. To our knowledge, there has been no examination of pNF-H ...
Wu Jiang J Department of Neurosurgery, Hebei Medical University, Shijiazhuang, - - 2014
Focal cortical dysplasia (FCD) is frequently associated with focal epilepsy, and a broad spectrum of histopathology is included in the diagnosis of FCD. In 2011, an International League Against Epilepsy (ILAE) task force proposed an international consensus for a classification system to better characterise specific clinicopathological FCD entities. The clinical ...
Matijevic Nena N Center for Translational Injury Research and Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, 6431 Fannin St. MSB 5.240, Houston, TX 77030, USA. Electronic address: - - 2014
Trauma-induced coagulopathy following severe injury is associated with increased bleeding and mortality. Injury may result in alteration of cellular phenotypes and release of cell-derived microparticles (MP). Circulating MPs are procoagulant and support thrombin generation (TG) and clotting. We evaluated MP and TG phenotypes in severely injured patients at admission, in ...
Pilbrow Anna P AP Christchurch Heart Institute, Department of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch 8011, New Zealand. Electronic address: - - 2014
The prognostic utility of circulating plasma microRNA in patients with acute coronary syndromes (ACS) has been proposed but not yet demonstrated. We set out to investigate circulating microRNA levels in patients incurring recent ACS and examined associations with neurohormones, cardiac structure and function, and survival over 5years of follow-up. An ...
Yeh Shin-Joe SJ From the Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, - - 2014
Pathogenetic classification of intracerebral hemorrhage (ICH), using systems such as SMASH-U (structural vascular lesions, medication, cerebral amyloid angiopathy [CAA], systemic disease, hypertension, or undetermined), is important in predicting functional outcomes and mortality in patients with ICH. This study aimed to compare pathogenetic subtypes between the first and recurrent ICH. This ...
Li Yanjie Y Laboratory Center of Diagnostics, Xuzhou Medical College, Xuzhou, - - 2014
We evaluated the potential relationship between miRNAs and Th17 cytokines in multiple myeloma (MM) patients. Twenty-seven newly diagnosed myeloma patients and eight normal donors were studied. We determined that the relative expression levels of miR-15a/16, miR-34a, miR-194 in MM patients were significantly lower than those in the healthy controls with ...
Hadiji N N Centre Bouffard-vercelli-Laboratoire de neuro-urologie et de sexologie, Cerbère, - - 2014
Objectives:To evaluate the efficacy of anticholinergic agents in the treatment of neurogenic overactive bladder (NOAB) and neurogenic detrusor overactivity (NDO) in spinal cord injury (SCI) patients on clean intermittent catheterisation (CIC).Methods:Chronic suprasacral SCI patients on CIC presenting with at least one urinary leakage a day were included. Urodynamics and voiding ...
Wang L L Department of Orthopedics, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, - - 2014
Background: Rheumatoid arthritis a chronic inflammatory autoimmune disease with inflammation of the joint, leading to damage of bone and surrounding cartilage. Objectives: Our study was designed to find the efficacy of etanercept, infliximab and methotrexate in effective therapeutic management against arthritis patients. Methods: A total of 315 patients, including both ...
Stecco A A Sport Medicine Unit, Department of Internal Medicine, University of Padova, Via Giustiniani 2, 35127, Padua, Italy, - - 2014
Achilles tendon analysis represents one of the most frequently requested ultrasonographic evaluations, due to the high incidence of tendinopathy. Various authors have described inflammatory features of the paratenon recruited 22 subjects complaining of pain in the mid-portion of the Achilles tendon and 22 healthy subjects. Both groups underwent ultrasonographic examination ...
Fleischmann Roy R Metroplex Center for Clinical Research, Dallas, TX, - - 2014
Abstract Objective Evaluate efficacy of infliximab with response-driven dosing in patients with active RA. Research design and methods: Patients (n=203) with active RA despite methotrexate+etanercept/adalimumab, participated in this active-infliximab-switch study. Infliximab 3mg/kg was infused at Weeks0, 2, 6, 14 and 22 with escalation to 5 or 7mg/kg depending on EULAR ...
Pietiläinen-Nicklén Jenna J Department of Virology, Haartman Institute, University of Helsinki, Finland; Department of Neurology, University of Helsinki, Finland. Electronic address: - - 2014
The triggering agent of multiple sclerosis is still unknown and many viruses, including human herpesvirus-6 (HHV-6), are under suspicion. In earlier study we found patients who had HHV-6 reactive OCBs in their CSF. We wanted to investigate whether HHV-6 has an active role in diseases with demyelination. To analyze the ...
Ramiro Sofia S Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Rheumatology, Hospital Garcia de Orta, Almada, - - 2014
Objectives: To analyze whether erosion, sclerosis and squaring assessed on radiographs precede the development of subsequent syndesmophytes in patients with ankylosing spondylitis (AS). Methods: Patients with AS from the Outcome in Ankylosing Spondylitis International Study (OASIS) cohort were followed with 2-yearly radiographs for a period of 12 years. Two readers ...
Shindo Akihiro - - 2014
The Kii peninsula of Japan is one of the foci of amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) in the world. The purpose of this study is to clarify the neuropsychological features of the patients with ALS/PDC of the Kii peninsula (Kii ALS/PDC). The medical interview was done on 13 ...
Nagappan Poongkodi P Department of Paediatric Urology, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, United - - 2014
To assess the prevalence of internal spermatic venous malformations in adolescent patients with varicocele using intra-operative antegrade venography. Over a 2 year period, adolescent boys with visible or palpable varicocele underwent antegrade venography before varicocele surgery. Antegrade venography was performed through a scrotal incision. A vein within the pampiniform plexus ...
Grzegorzewska Alicja E - - 2014
INTRODUCTION Atherogenic dyslipidemia accelerates development of cardiovascular complications and contributes to mortality of hemodialysis (HD) patients. OBJECTIVES Our aim was to evaluate effects of lifestyle changes followed by medication with atorvastatin (ATO) in dyslipidemic HD patients. PATIENTS AND METHODS Dyslipidemic HD patients (n = 49) were enrolled into the prospective study. Forty two ...
Domenicali Marco M Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Italy; Center for Applied Biomedical Research (C.R.B.A.), S.Orsola-Malpighi University Hospital, Bologna, - - 2014
Background & Aims. Beside the regulation of fluid distribution, human serum albumin (HSA) carries other activities, such as binding, transport and detoxification of many molecules. In patients with cirrhosis, HSA presents post-transcriptional alterations which likely affect its functions. This study aimed at identifying the structural HSA alterations occurring in cirrhosis ...
Magnard Justine J University of Nantes, Laboratory "Motricité, Interactions, Performance" (UPRES EA 4334), F-44000 Nantes, - - 2014
Elderly patients with end stage renal diseases (ESRD) undergoing hemodialyis (HD) present poorer physical function and higher accident falls than healthy elderly population. Therefore, the aim of this study was to examine the HD-related changes in postural sway in ESRD patients, as an objective hallmark of their functional abilities. We ...
Tang Sung-Chun SC Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan NTU-NTUH-MediaTek Innovative Medical Electronics Research Center, Taipei, - - 2014
Heart rate variability (HRV) has been proposed as a predictor of acute stroke outcome. This study aimed to evaluate the predictive value of a novel non-linear method for analysis of HRV, multiscale entropy (MSE) and outcome of patients with acute stroke who had been admitted to the intensive care unit ...
Tarkkanen Ahti H A AH Department of Ophthalmology, Helsinki University Central Hospital, Helsinki - - - 2014
To report vascular comorbidities, arterial hypertension (HT), ischemic heart disease (IHD), and diabetes mellitus (DM) in patients with low-tension glaucoma (LTG) with maximum intraocular pressure (IOP) of 18 mm Hg or less. Uniform criteria for glaucoma and the comorbidities were applied. We reviewed records of 519 consecutive patients to whom ...
Zhang J-J JJ Department of Hepatology, Qilu Hospital of Shandong University, Jinan, - - 2014
Suppressor of cytokine signalling 1 (SOCS1) was demonstrated to play an important negative role in fulminant hepatitis and might be involved in acute-on-chronic hepatitis B liver failure (ACHBLF). This study was therefore to identify the potential role of SOCS1 and its promoter methylation pattern in ACHBLF patients. Sixty ACHBLF patients, ...
Shao Ning N Department of Urology, Second People's Hospital of Wuxi Affiliated to Nanjing Medical University, 68 Zhongshan Road, Wuxi, 214002, People's Republic of - - 2014
Acute aortic dissection (AAD) is a life threatening cardiovascular medical emergency with a poor prognosis. To explore the utility of D-dimers (DD) in the diagnosis of AAD, we performed a prospective study and conducted a meta-analysis of previous studies. 368 suspected patients were enrolled, including AAD n = 89, PE n = 12, AMI ...
Su C-C CC Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, - - 2014
Cirrhosis patients have immunologic insufficiency and a high seroprevalence of human herpesvirus type 8 (HHV-8). Nearly all hepatocellular carcinoma (HCC) patients are cirrhotic and have immunoabnormalities. This study aimed to assess the HHV-8 seroprevalence and hemograms in HCC patients. Blood samples from 95 HCC patients, 95 age-, sex-, and Child-Pugh ...
Keizer Anouk A Experimental Psychology/Helmholtz Institute, Utrecht University, P.O. Box 80140, 3508TC, Utrecht, The Netherlands. Electronic address: - - 2014
Anorexia nervosa (AN) patients show disturbances in body size experience. Here, malleability of body representation was assessed by inducing the Rubber Hand Illusion (RHI). Specifically the impact of the illusion on body size estimation was investigated. Thirty AN patients and thirty healthy females participated. The RHI was induced synchronously (experimental ...
Sanaka Madhusudhan R MR Departments of Gastroenterology, Desk Q3-1, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44136, USA, - - 2014
Colonic configuration during insertion phase (IP) and withdrawal phase (WP) is different and some polyps seen during IP are difficult to find during WP and vice versa. To determine if polypectomy performed during both IP and WP of colonoscopy (study arm) increases adenoma detection rate (ADR) compared to WP only ...
Prichard Roslyn A RA Center for Cardiovascular and Chronic Care, University of Technology, Sydney - - - 2014
Six-minute walk distance (6MWD) and maximal oxygen uptake (VO2 max ) are used as prognostic tools in patients with heart failure (HF). Whether these tests provide similar information in the LVAD population is not known. Eight patients supported with VentrAssist rotary blood pump LVADs, underwent three days of testing that included ...
Imperatori Claudio C Department of Human Sciences, Università Europea, Rome, Italy. Electronic address: - - 2014
The aim of the present study was to explore the modifications of EEG power spectra and EEG connectivity of resting state (RS) condition in patients with post-traumatic stress disorder (PTSD). Seventeen patients and seventeen healthy subjects matched for age and gender were enrolled. EEG was recorded during five minutes of ...
Noris Marina M IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases, Centro Anna Maria Astori Science and Technology Park Kilometro Rosso, Bergamo, - - 2014
Atypical hemolytic-uremic syndrome (aHUS) is associated with genetic complement abnormalities/anti-CFH antibodies, which paved the way to treatment with Eculizumab. We studied 44 aHUS patients and their relatives to: 1) test new assays of complement activation; 2) verify whether such abnormality occurs also in unaffected mutation carriers; 3) search a tool ...
Koo Bon San BS Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center , Seoul , South - - 2014
Objective. The purpose of our study was to determine the number of IgG4-related retroperitoneal fibrosis (RPF) cases that were initially diagnosed as idiopathic RPF and to investigate clinical characteristics of IgG4-related RPF. Methods. We retrospectively reviewed the medical records of 41 RPF patients who were treated at our tertiary care ...
Levy R R Paediatric Rheumatology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, - - 2014
To evaluate genetic, demographic and clinical features in patients with cryopyrin-associated periodic syndrome (CAPS) from the Eurofever Registry, with a focus on genotype-phenotype correlations and predictive disease severity markers. A web-based registry retrospectively collected data on patients with CAPS. Experts in the disease independently validated all cases. Patients carrying NLRP3 ...
Dragutinović Vesna V VV Institute of Medical Chemistry, School of Medicine, University of Belgrade, Belgrade, Serbia, - - 2014
Preoperative diagnosis of papillary thyroid carcinoma (PTC) comprises numerous diagnostic procedures which are mostly applicable in tertiary institutions. Normal thyroid function depends on the presence of many trace elements and copper (Cu) and zinc (Zn) are some of those. The study is based on retrospective review of 118 patients with ...
Wang Dan-Dan DD Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, - - 2014
Sturge-Weber syndrome (SWS) is a rare syndrome characterized by capillary-venous malformations involving skin and brain. Many patients with SWS also suffer from drug resistant epilepsy. We retrospectively studied a series of six SWS patients with epilepsy and extensive neurosurgical resections. At time of surgery, the patients' age ranged from 11 ...
Windschall D D Department of Pediatrics, Asklepios Hospital Weissenfels, Naumburgerstrasse 76, 06667, Weissenfels, Germany, - - 2014
The approval of etanercept for the treatment of the juvenile idiopathic arthritis (JIA) categories extended oligoarthritis (ExtOA), enthesitis-related arthritis (ERA) and psoriasis arthritis (PsA) was recently added to the approval for the treatment of polyarticular-course JIA (PA). This study aims to evaluate the efficacy and safety of etanercept in a ...
Radbruch Alexander A Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany (A.R., J.F., P.K., P.B., S.H., M.B.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R., H.-P.S.); Department of Neurooncology, Neurology Clinic and National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany (B.W., A.W., W.W.); German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany (B.W., A.W., W.W.); Department of Neurology, Innsbruck Medical University, Innsbruck, Austria - - 2014
According to the Response Assessment in Neuro-Oncology criteria, new enhancement within the radiation field on contrast enhanced T1-weighted images within 12 weeks after completion of radiotherapy should not qualify for progressive disease, since up to 50% of these cases may be pseudoprogression (PsP). To validate this concept, we assessed incidence ...
Blumencranz Peter W PW Comprehensive Breast Care Center of Tampa Bay, Morton Plant Hospital, Clearwater, FL, USA, - - 2014
The purpose of this study was to determine whether breast biopsy tissue markers composed of an ultrasound-visible hydrogel reduced the need for preoperative wire localization (WL) in patients undergoing a partial mastectomy. A single-surgeon, single-institution, retrospective chart review was performed on 691 consecutive female patients, with mean age 67 years (range ...
Zhang Yan Y Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address: - - 2014
To explore the role of middle latency evoked potentials (EPs) as predictors for favorable outcome in patients with severe ischemic brain injuries by comparing the prognostic ability of short latency somatosensory and auditory evoked potentials (SLSEP and BAEP) with middle latency somatosensory and auditory evoked potentials (MLSEP and MLAEP). MLSEP, ...
Beck Jürgen J Departments of - - 2014
Object The etiology of chronic subdural hematoma (CSDH) in nongeriatric patients (≤ 60 years old) often remains unclear. The primary objective of this study was to identify spinal CSF leaks in young patients, after formulating the hypothesis that spinal CSF leaks are causally related to CSDH. Methods All consecutive patients ...
Ishimura Norihisa N Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, - - 2014
The prevalence rates of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) arising from BE show striking geographic patterns as they are much more common in Western as compared with Asian countries. However, recent epidemiological studies indicate that the number of patients with BE and EAC are gradually increasing in Asia ...
Martinic-Popovic Irena I University Department of Neurology, Medical School University Hospital Sestre milosrdnice, Zagreb, - - 2014
Inflammatory mediators have an important role in the pathogenesis of stroke. Increased activity of inflammatory mediators initiates the development of atherosclerosis independently of other risk factors, thus compromising brain microcirculation and causing transient ischemic attack (TIA). The aim of our study was to evaluate the relationship between serum level of ...
Sadnicka A A Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, - - 2014
Traditionally dystonia has been considered a disorder of basal ganglia dysfunction. However, recent research has advocated a more complex neuroanatomical network. In particular, there is increasing interest in the pathophysiological role of the cerebellum. Patients with cervical and focal hand dystonia have impaired cerebellar associative learning using the paradigm eyeblink ...
Yousefzai Rayan R Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, - - 2014
Ischemic mitral regurgitation (IMR) is associated with poor outcomes in patients with coronary artery disease. The impact of percutaneous coronary intervention (PCI) on patients with IMR is not well elucidated. We sought to determine the outcomes of patients with severe IMR who underwent PCI. Patients with severe (≥3+) IMR who ...
Bharadwaj Shishira S Cleveland Clinic, Cleveland, Ohio - - 2014
Previous studies have suggested a high prevalence of vitamin D deficiency in patients receiving long-term home parenteral nutrition (HPN). The aim of this study was to determine the prevalence and predictors of vitamin D deficiency in long-term HPN patients. Methods: A retrospective, institutional review board-approved study was performed on all ...
Park Kyu Hyung KH Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University Bundang Hospital, #300, Gumi-dong, Bundang-gu, Seongnam, Gyeonggi-do, 463-707, Korea (South), Republic - - 2014
Purpose:To investigate the associations of the Wnt modulators Wnt inhibitory factor 1 (WIF-1) and Dickkopf 3 (DKK-3) in the aqueous humor (AH) with neovascular age-related macular degeneration (nAMD) and to determine their clinical implications. Methods:Seventy-four nAMD patients initially treated with an intravitreal injection of ranibizumab (IVR) and 74 age- and ...
Wan Catherine Y CY Department of Neurology, Neuroimaging and Stroke Recovery Laboratories, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, - - 2014
Using a pre-post design, eleven chronic stroke patients with large left hemisphere lesions and nonfluent aphasia underwent diffusion tensor imaging and language testing before and after receiving 15weeks of an intensive intonation-based speech therapy. This treated patient group was compared to an untreated patient group (n=9) scanned twice over a ...
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