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Lee Hye Won HW 1] Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea [2] The first two authors contributed equally to this - - 2014
OBJECTIVES:In the era of antiviral therapy, the prognostic significance of serum hepatitis B virus (HBV) DNA level as a biological gradient substantially diminished, as most patients can achieve complete virological response (CVR). We aimed to investigate the predictive roles of liver stiffness (LS) for liver-related events (LREs) among patients with ...
Ferrazzano Gina G Department of Neurology and Psychiatry, 'Sapienza' University of Rome, Rome, - - 2014
The aim of the study was to investigate the effect of botulinum toxin (BoNT) on blink rate (BR) in patients with blepharospasm (BSP) and increased blinking (IB). 37 patients with a clinical diagnosis of primary BSP (19 patients had tonic orbicularis oculi (OO) spasms and 18 patients had clonic OO ...
Horn David L DL Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine; Division of Pediatric Otolaryngology, Seattle Children's Hospital, Seattle, Washington, USA - - 2014
This study aimed to investigate the role of interarytenoid injection laryngoplasty (IL) for the management of pediatric aspiration. Medical records of 30 patients, 9 female, with radiographically confirmed chronic aspiration who underwent intraoperative IL were retrospectively reviewed. Clinical improvement was defined as successful advancement of feeds to thinner consistencies. Clinical ...
Spada Cristiano C Digestive Endoscopy Unit, Catholic University, Rome, - - 2014
In case of incomplete colonoscopy, several radiologic methods have traditionally been used, but more recently, capsule endoscopy was also shown to be accurate. Aim of this study was to compare colon capsule endoscopy (CCE) and CT colonography (CTC) in a prospective cohort of patients with incomplete colonoscopy. Consecutive patients with ...
Lee Young Chan YC Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Seoul, - - 2014
To investigate salivary function in patients with primary burning mouth syndrome (BMS) compared to control and to evaluate salivary hypofunction using salivary gland scintigraphy (SGS). A total of 33 patients with primary BMS and 30 control subjects were enrolled in our study. The severity of the pain and the burning ...
Kawada Noritaka N Health Care Center, Osaka University, - - 2014
This study determined the parameters for predicting the clinical effects of eplerenone (Ep) add-on therapy on blood pressure (BP) and proteinuria in patients taking angiotensin-converting enzyme inhibitors (ACEis) or angiotensin II type I receptor blockers (ARBs). Patients were treated with a gradual increase of Ep to a final dose of ...
Truszczyńska Aleksandra A Faculty of Physical Education and Sport in Biała Podlaska, Józef Piłsudski University of Physical Education, Warsaw, Poland Professor A. Gruca Independent Public Research Hospital, Otwock Department of Orthopedic Surgery, Center of Postgraduate Medical Education, Otwock, Poland Faculty of Rehabilitation, Józef Pi{l}sudski University of Physical Education in Warsaw, Warsaw, - - 2014
The available literature is lacking in reports on the quantitative analysis of posture in patients with lumbar stenosis. The aim of this study was to analyze body posture in patients with lumbar spinal canal stenosis. The study involved 100 people: 49 persons with severe lumbar spine stenosis and 51 control ...
Radwan Ahmed A Physical Therapy Program, Utica College, Utica, NY, - - 2014
To evaluate the extent of intra-subject difference in hamstring flexibility and its possible relationship to the severity of Low Back Pain (LBP). A secondary purpose was to evaluate the extent of intra-rater reliability using both electrogoniometer and conventional goniometer for measuring hamstring tightness. Potential correlations between muscle impairments and LBP ...
Alfirevic Andrej A Department of Cardiothoracic Anesthesia, Cleveland Clinic, Cleveland, Ohio. Electronic address: - - 2014
Recombinant activated factor VII (rFVIIa) decreases requirements for allogeneic blood transfusion and chest reexploration in patients undergoing cardiac surgery. Whether rFVIIa increases the risk of postoperative adverse events is unclear. We tested whether rFVIIa administration was associated with increased mortality and neurologic and renal morbidity in patients undergoing cardiac surgery. ...
Kuniyoshi Kazuki K Schepens Eye Research Institute, Harvard Medical School, Boston, Mass., - - 2014
Purpose: To determine whether the characteristics of multifocal electroretinograms (mfERGs) were correlated with the ophthalmic appearance of the fundus in patients with Stargardt's disease/fundus flavimaculatus (SFF). Methods: Full-field ERGs, mfERGs, and general ophthalmic examinations were performed on 49 eyes with SFF. Results: The SFF patients were divided into four subtypes ...
Sildorf Stine Møller SM Pediatric Department, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark. Electronic address: - - 2014
The incidence of type 1 diabetes (T1D) has during the last few decades been increasing in children and juveniles. Multi-factorial courses combining genetic disposition and environmental factors might be in play, and through the years, there has been a mounting interest in the innate immune system's role in the development ...
Salsone M M Neuroimaging Research Unit, National Research Council, Catanzaro, - - 2014
REM sleep behavior disorder (RBD) is a common non motor feature of Parkinson's Disease (PD) affecting about half the patients with this disease. Distinct structural brain tissue abnormalities have been reported in several regions modulating REM sleep of the patients with idiopathic RBD. At the present time, there are no ...
Hong Jin Yong JY Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Republic of - - 2014
Subjective cognitive decline (SCD) has gained attention as a predictor of future cognitive decline in neurodegenerative diseases. Based on the hypothesis that different pathologies may distinctly contribute to SCD, we investigated the cognitive profiles and cortical thickness of patients with SCD, with and without Parkinson's disease (PD). In total, 96 ...
Kalita Jayantee J Department of Neurology, Sanjay Gandhi Post Graduate medical Sciences, Lucknow, India. Electronic address: - - 2014
Free copper in Wilson disease (WD) is toxic and may reduce antioxidant, increase oxidative stress marker and thereby cytokine release and excitotoxic injury, but there is paucity of studies in humans. We report oxidative stress markers, cytokines and glutamate in neurologic WD and correlate these with their clinical severity, laboratory ...
Shemisa Kamal - - 2014
The cardiovascular consequences related to amyotrophic lateral sclerosis are relatively underappreciated. The disease invokes a systematic degeneration of autonomic neurons leading to autonomic dysfunction. We therefore hypothesized that patients with amyotrophic lateral sclerosis may have a predilection to the development of cardiac conduction disorders. A 65-year-old Caucasian man with advanced ...
Düring Signe S 1] Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark [2] Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark [3] Faculty of Health Sciences, Dept. of Neurology, Psychiatry, and Sensory Sciences, University of - - 2014
It has been suggested that psychophysiological measures of sensory- and sensorimotor gating, P50 gating and prepulse inhibition of the startle reflex (PPI), underlie core features of schizophrenia and are linked to dopaminergic pathways in the striatum and prefrontal cortex. In the present study, the effects of a potent D2/D3 receptor ...
Mekawy Mohamed A MA Department of Clinical Pathology, Hematology Unit - - 2014
Abstract In patients with end-stage renal disease (ESRD), hemorrhagic complications are commonly encountered due to abnormalities in primary hemostasis, in particular, platelet (PLT) dysfunction and impaired PLT-vessel wall interaction. The pathogenesis of altered PLT function is considered multifactorial. Dialysis procedures had a favorable impact on bleeding complications in uremic patients. ...
Melero-Ferrer Josep Lluís JL Unidad de Cardiopatías Congénitas del Adulto, Servicio de Cardiología, Área Clínica del Corazón, Hospital Universitari i Politècnic La Fe, Valencia, España - - 2014
The development of liver fibrosis and cirrhosis due to long-standing liver congestion is known to occur in adult patients with Fontan circulation. Hepatic elastography has shown to be a useful tool for the noninvasive assessment and staging of liver fibrosis in chronic liver diseases, although the utility of this technique ...
Addimanda Olga O Rheumatology Unit, Arcispedale Santa Maria Nuova, I.R.C.C.S, Reggio Emilia, Italy. - - 2014
Tocilizumab (TCZ) is an effective treatment in patients with rheumatoid arthritis (RA) refractory to anti-tumour necrosis factor-α. However, only few studies in real life have evaluated the efficacy of TCZ in long-standing rheumatoid arthritis (LSRA). Our aim was to evaluate the efficacy and safety of tocilizumab in refractory LSRA. Twenty-seven ...
Katzka David A DA Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Minnesota, United - - 2014
Eosinophilic oesophagitis (EoE) is presumed to be an isolated oesophageal disease; yet other allergic diseases associated with eosinophilic infiltration of target tissues, such as asthma and eczema, show perturbed functions of other sites that may be involved in the diathesis of allergy modulation. To analyse small intestinal permeability in patients ...
Lener Marc S MS Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, - - 2014
Prior diffusion tensor imaging (DTI) studies examining schizotypal personality disorder (SPD) and schizophrenia, separately have shown that compared with healthy controls (HCs), patients show frontotemporal white matter (WM) abnormalities. This is the first DTI study to directly compare WM tract coherence with tractography and fractional anisotropy (FA) across the schizophrenia ...
Wang Chun-Ya - - 2014
Few data can be available regarding acute liver failure (ALF) caused by severe acute hepatitis B up to now. This study aims to report such cases from China. We conducted a multi-center investigation on ALF from 7 tertiary hospitals in different areas of China. A total of 11 patients with ...
Doganer Yusuf C YC aDepartment of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA bDepartment of Family Medicine cDepartment of Cardiology dDepartment of Biochemistry, Gulhane Military Medical Faculty eDepartment of Cardiology, Etimesgut Military Hospital, Ankara fBalmumcu Family Health Center, Gumussuyu Military Hospital, Istanbul, - - 2014
Inflammation is one of the numerous factors that promote atherosclerosis. Cystatin-C (Cys-C) and pentraxin-3 (PTX-3) predominantly play roles in inflammation. Thus, we evaluated whether these markers were related to the presence and severity of coronary artery disease (CAD). Eighty-two stable patients who had undergone coronary angiography were enrolled in the ...
Bria Emilio E Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy. Electronic address: - - 2014
The combination of trastuzumab and chemotherapy is currently considered the standard of care for patients with locally advanced/operable human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The potential correlation between the pathologic complete response (pCR) and the overexpression of heat shock protein 90 (Hsp90), Ki67, and the amplification of ...
Ortigoza-Escobar Juan Darío - - 2014
The clinical characteristics distinguishing treatable thiamine transporter-2 deficiency (ThTR2) due to SLC19A3 genetic defects from the other devastating causes of Leigh syndrome are sparse. We report the clinical follow-up after thiamine and biotin supplementation in four children with ThTR2 deficiency presenting with Leigh and biotin-thiamine-responsive basal ganglia disease phenotypes. We ...
Hammoudi Nadjib N Department of Cardiology, Institut de Cardiologie, Pitié-Salpêtrière Hospital (Groupe Hospitalier Pitié-Salpêtrière), Assistance Publique - Hôpitaux de Paris, 47-83, boulevard de l'Hôpital, 75651, Paris Cedex 13, France, - - 2014
Chronic volume overload in sickle-cell anemia (SCA) is associated with left ventricular (LV) enlargement and hypertrophy. The effect of the disease on LV systolic function remains debated. The aim of our study was to investigate LV systolic function in SCA patients using 2D speckle-tracking imaging. We compared 30 steady state ...
Uher Tomas T Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech - - 2014
Cognitive impairment (CI) may occur in clinically isolated syndrome (CIS) patients. While the relationship between CI and magnetic resonance imaging (MRI) has been investigated extensively in multiple sclerosis (MS), MRI correlates of CI in CIS patients are unknown. To investigate the evolution of CI and to determine brain MRI structural ...
Lauseker Michael M Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität, Munich, - - 2014
Chronic myeloid leukemia (CML) patients are monitored by both cytogenetic and molecular assessments, although present guidelines appear to switch from cytogenetic to molecular criteria. Due to the increasing use of molecular measurements, it was the aim of this work to identify a BCR-ABL level according to the international scale (BCR-ABL(IS)) ...
Havali Cengiz C Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey - - 2014
The aim of this study was to investigate the effects of valproate and carbamazepine, on renal glomerular and tubular functions. The patient group comprised 54 children with new-onset epilepsy treated with valproate (n = 30) and carbamazepine (n = 24). Twenty-six healthy children were in the control group. The serum ...
Korzeniecka-Kozerska A A Department of Pediatrics and Nephrology, Medical University of Bialystok, 17 Waszyngtona Street, 15-274, Bialystok, Poland, - - 2014
Detrusor overactivity (DO) is one of the most frequent bladder dysfunctions in children up to the age of 18. Nowadays, the only way to confirm DO is by urodynamic investigation, which is an invasive procedure. Among the many mediators influencing bladder function, nerve growth factor (NGF) plays an important role. ...
Cornec Divi D Department of Rheumatology, Brest Teaching Hospital, Brest, - - 2014
Primary Sjögren's syndrome (pSS) is a frequent autoimmune systemic disease, clinically characterized by eyes and mouth dryness in all patients, salivary gland swelling or extraglandular systemic manifestations in half of the patients, and development of lymphoma in 5 to 10 % of the patients. However, patients presenting with sicca symptoms or ...
Boronat Susana S Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Paediatric Neurology, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, Barcelona, - - 2014
Patients with tuberous sclerosis complex (TSC) with brain involvement usually have both tubers and subependymal nodules (SENs) and the occurrence of one lesion without the other seems to be rare. The aim of this study was to assess the specific clinical manifestations and genotype of patients with one type of ...
Armentia A A Allergy Unit, University Hospital Rio Hortega, Valladolid, Spain. Electronic address: - - 2014
Eosinophilic oesophagitis (EoE) is a disorder characterised by oesophageal dysfunction and, histologically, by eosinophilic inflammation. Although treatment, which includes dilatations, oral corticosteroids and restrictive diets, is often effective, choosing the foods to be eliminated from the diet is difficult. Component resolved diagnostic by microarray allergen assay may be useful in ...
Chin Theresa L TL University of Colorado Denver, Denver, - - 2014
The mechanisms driving trauma-induced coagulopathy (TIC) remain to be defined, and its therapy demands an orchestrated replacement of specific blood products. Thrombelastography (TEG) is a tool to guide the TIC multicomponent therapy. Principal component analysis (PCA) is a statistical approach that identifies variable clusters; thus, we hypothesize that PCA can ...
Zhu Bing B Bing Zhu, Shao-Li You, Zhi-Hong Wan, Hong-Ling Liu, Yi-Hui Rong, Hong Zang, Shao-Jie Xin, Liver Failure Treatment and Research Center, 302 Military Hospital, Beijing 100039, - - 2014
To investigate the clinical features, response to corticosteroids, and prognosis of autoimmune hepatitis (AIH)-induced liver failure in China. A total of 22 patients (19 female and 3 male; average age 51 ± 15 years) with AIH-induced liver failure treated in our hospital from 2004 to 2012 were retrospectively analyzed. Clinical, ...
Kim Su Hwan SH Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul, South - - 2014
Background/Aims: Spontaneous small-bowel perforation caused by Crohn's disease (CD) or intestinal tuberculosis (ITB) is a rare disease entity. We investigated the clinical features and radiologic findings of patients with CD or ITB who presented with a spontaneous small-bowel perforation. Methods: Between January 2001 and December 2010, sixty-two patients underwent surgery ...
Daubail Benoit B Dijon Stroke Registry, EA4184, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, - - 2014
Background: The prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency is high in patients presenting with an acute stroke, and it may be associated with greater clinical severity and a poor early functional prognosis. However, no data about its impact on long-term prognosis is available. In this study, we aimed to assess ...
Pulkes Teeratorn T Division of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: - - 2014
LRRK2 p.R1628P (c.4883G > C) is associated with Parkinson's disease (PD) in Chinese and Thais. However, some studies in other East Asian ethnic groups did not observe this association. Carriers of p.R1628P are about 3-5% Chinese and Thais. In contrast, Japanese, Koreans and Malays are much less prevalent (0-<1%). The contradictory results ...
Parsikia Afshin A From the Department of Surgery, Einstein Healthcare Network, Philadelphia, - - 2014
Trauma patients require early assessment of injury severity. Trauma scores, although well validated, can be unwieldy in the emergency clinical setting. We sought to evaluate the prognostic value of initial serum lactate (ISL) for mortality, operative intervention (OI), and ICU admission (ICUA) in trauma patients. We conducted an IRB-approved retrospective ...
Park Jin Su JS Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South - - 2014
We evaluated the effects of concurrent use of methotrexate and celecoxib on silent liver and kidney damages in rheumatoid arthritis (RA) patients. We enrolled 92 RA patients with normal laboratory results related to liver and kidney functions, who had received methotrexate and celecoxib concurrently over 6 months. Liver stiffness measurement (LSM) ...
Ingram Martha-Conley E MC Department of Neurosurgery, Emory University; - - 2014
Object Intraventricular hemorrhage (IVH) is the most common cause of hydrocephalus in the pediatric population and is particularly common in preterm infants. The decision to place a ventriculoperitoneal shunt or ventricular access device is based on physical examination findings and radiographic imaging. The authors undertook this study to determine if ...
Kim Yu Ri YR Division of Hematology, Department of Internal Medicine, Gangnam Severance Hospital, Seoul, South - - 2014
Elevated serum free light chain (FLC) is known to be an adverse prognostic factor for diffuse large B-cell lymphoma (DLBCL). We hypothesized that monoclonal gammopathy (MG; elevated kappa [κ] or lambda [λ] FLC with an abnormal κ/λ ratio or a positive IF [immunofixation]) and polyclonal gammopathy (PG; elevated κ and/or ...
Yamamoto Masaaki M Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, - - 2014
Colorectal neoplasms are well known to be a complication in cases of acromegaly; however, data on the prevalence of colorectal neoplasms in Asian patients with acromegaly are limited. Further, the factors associated with colorectal neoplasms in cases of acromegaly are controversial. Therefore, we aimed to clarify the prevalence of and ...
Yoshida Hiroki H Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Tokyo, - - 2014
Object The purpose of this study was to describe significant CT myelography findings for determination of the leak site and outcome of targeted epidural blood patch (EBP) in patients with spontaneous CSF leaks. Methods During 2005-2013, spontaneous CSF leaks were diagnosed for 12 patients with orthostatic headaches. The patients received ...
Koljević Marković Ana A Department of Nuclear Medicine, National Cancer Research Center of Serbia, Pasterova 14, 11000, Belgrade, Serbia, - - 2014
The aim was quantitative assessment of parathyroid adenoma (PTA) uptake in dual tracer dynamic scintigraphy. In 78 patients, median age 58 (19-80) years, surgically treated for primary hyperparathyroidism (PHPT), with parathyroid hormone median 125 (70-658) pg/ml, we performed preoperative parathyroid scintigraphy, following EANM guidelines of subtraction and double-phase protocol (2009) using ...
Lisson Jörg A - - 2014
Objectives: Primary surgery in patients with complete unilateral and bilateral cleft lip and palate restricts transverse and sagittal maxillary growth. Additional surgical maxillary advancement might become necessary after completion of growth. The aim of this study was to determine the extent of maxillary deficiency at an early stage during the ...
Navaneethan Udayakumar U Department of Gastroenterology/Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA - - 2014
The interaction between inflammatory bowel disease (IBD) and hepatobiliary manifestations represents a classic example of liver-gut crosstalk. The importance of liver-gut crosstalk in IBD is demonstrated in the pathogenesis and outcome of primary sclerosing cholangitis (PSC) in IBD patients. Immunoglobulin G4-associated cholangitis (IAC), which has recently been described in UC ...
Delrieu Julien J Alzheimer's Disease Clinical Research Centre, Gérontopôle, Toulouse University Hospital, Toulouse, - - 2014
The goal of this study is to evaluate brain metabolism in mild cognitive impairment (MCI) patients with and without apathy (as determined by the Neuropsychiatric Inventory Questionnaire). Baseline data from 65 MCI participants (11 with apathy and 54 without) from the Alzheimer's Disease (AD) Neuroimaging Initiative study were analyzed. All ...
Westerhof Guus A GA Department of Respiratory Medicine, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam, The Netherlands. Electronic address: - - 2014
A proportion of patients with adult-onset asthma have severe disease. Risk factors for an increase in asthma severity are poorly known. We sought to identify predictors for the development of severe asthma in adults. A cohort of 200 adults with new-onset asthma was prospectively followed for 2 years. At baseline, ...
Imamura Teruhiko T Department of Cardiovascular Medicine, Graduate School of Medicine, University of - - 2014
Background:Preserved function of the renal collecting duct may be essential for response to the vasopressin V2receptor antagonist, tolvaptan (TLV), but the predictors of response to TLV are unknown.Methods and Results:Sixty consecutive patients with stage D decompensated heart failure (HF) who had received TLV on a de novo basis were retrospectively enrolled (TLV(+) ...
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