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Takeuchi Takako - - 2012
Iodine concentrations of enteral nutrition (EN) formulae available in Japan are very low and long-term total EN (TEN) might result in hypothyroidism due to iodine deficiency (HID). Our aim of this study was to determine the degree of iodine deficiency (ID) and need for iodine supplementation (IS) in patients with ...
Ozdemir Didem - - 2012
We aimed to determine the prevalence of parathyroid incidentalomas in patients referred for thyroid ultrasonography (US) and investigate the role of chronic thyroiditis on false positive lesions. Patients suspected to have parathyroid lesions during thyroid US were recorded prospectively between August 2009 and January 2010. Patients referred for parathyroid US ...
Karaca Z - - 2012
OBJECTIVE: The aim of the present study was to investigate the effects of growth hormone (GH) replacement on posterior pituitary functions of GH-deficient Sheehan's syndrome (SS) patients. DESIGN: Ten patients with SS and 14 healthy control women were included in this prospective study. All patients were given appropriate hormone replacement ...
Malysheva Olga - - 2012
OBJECTIVES: To further evaluate the impact of corticotropin releasing hormone (CRH) promoter polymorphisms on the stress response in rheumatoid arthritis (RA) patients an insulin hypoglycaemia test (IHT) was performed studying the dynamics of CRH production. METHODS: Polymorphisms of the human CRH promoter were determined in controls and cortisol naive patients ...
Takahashi Tsutomu - - 2012
This longitudinal MRI study investigated the pituitary volume in 17 patients with chronic schizophrenia and 17 matched controls. In contrast to previous findings of pituitary expansion during the first episode of schizophrenia, the chronic patients showed non-significant mild pituitary atrophy, suggesting that the pituitary volume changes differently at different illness ...
Lawrenz Barbara - - 2012
OBJECTIVE: To study whether the ovarian reserve in female lymphoma patients is already reduced before the start of chemotherapy. DESIGN: Age-matched control study. SETTING: Women's university hospital. PATIENT(S): Female patients aged <40 years with the initial diagnosis of lymphoma (study group) were compared with age-matched healthy volunteers (control group). Eighty-four ...
Lie Octavian V - - 2012
We report a patient with longstanding, severe juvenile myoclonic epilepsy who subsequently developed features of temporal lobe epilepsy, which gradually became clinically dominant. Over the years, there was an electrographic evolution from the typical generalised epileptiform patterns, characteristic of juvenile myoclonic epilepsy, to the novel appearance of interictal temporal spikes ...
Rho Myung Ho - - 2012
Detection of antithyroid peroxidase antibody (TPOAb) is widely used in the diagnosis of autoimmune thyroiditis (AIT), but no research has evaluated the diagnostic accuracy of TPOAb detection using histopathologic reference standards. To fill this research gap, this study assessed the diagnostic accuracy of detection of TPOAb and that of other ...
Ertek Sibel - - 2012
The current medical literature has conflicting results about factors related to hypothyroidism and nodular recurrences during follow-up of hemithyroidectomized patients. We aimed to evaluate factors that may have a role in new nodule formation, hypothyroidism, increase in thyroid lobe and increase in nodule volumes in these patients with and without ...
Vortmeyer Alexander O - - 2012
McCune-Albright syndrome (MAS) is caused by sporadic mutations of the GNAS. Patients exhibit features of acromegaly. In most patients, GH-secreting pituitary adenomas have been held responsible for this presentation. However, surgical adenomectomy rarely eliminates excess GH production. The aim of this study was to elucidate pituitary pathology in patients with ...
Hamdan Abdul-Latif - - 2012
OBJECTIVE: The aim of the present study was to describe the vocal characteristics of patients with thyroiditis in a clinical setting. MATERIALS AND METHODS: A total of 17 consecutive patients with the diagnosis of thyroiditis presenting to the endocrinology clinic were invited to participate in the study. A group of ...
Min Le L Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, - - 2012
To present a case series of ipilimumab-related secondary adrenal insufficiency. In this cases series, we review the presentation, evaluation, diagnosis, and management of patients with advanced melanoma who received ipilimumab and were referred to our endocrinology clinic for evaluation of hormonal abnormalities. Seven patients presented with symptoms, signs, or biochemical ...
Sporea Ioan I Ioan Sporea, Roxana Sirli, Simona Bota, Alina Popescu, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timisoara, 300736 Timisoara, - - 2012
To assess whether acoustic radiation force impulse (ARFI) elastography can differentiate normal from pathological thyroid parenchyma. We evaluated 136 subjects (mean age 45.8 ± 15.6 years, 106 women and 30 men): 44 (32.3%) without thyroid pathology, 48 (35.3%) with Basedow-Graves' disease (GD), 37 (27.2%) with chronic autoimmune thyroiditis (CAT; diagnosed ...
Suk J - - 2012
Evidence exists that autoimmune thyroiditis is present in a high percentage of fibromyalgia (FM) and associated with the presence of typical symptoms of FM. However, the role of thyroperoxidase antibody (TPO Ab) in the manifestation of FM is still unclear. The goal of this study was to investigate the prevalence ...
Liu Xiaomin - - 2012
Gamma knife radiosurgery (GKRS) is an important additional strategy for unresected clinically active pituitary adenomas. Radiosurgery for acromegaly aims to achieve tumor growth control and endocrine remission, potentially obviating the need for lifetime medication suppression therapy. Forty patients with clinically active acromegaly underwent GKRS between 1988 and 2009. Thirty-four patients ...
Nishizawa Hitoshi - - 2012
Backgound: Liver dysfunction in adult hypopituitary patients with growth hormone deficiency (GHD) has been reported and an increased prevalence of nonalcoholic fatty liver disease (NAFLD) has been suggested.Objective: The objective of the study was to elucidate the pathophysiology of the liver in adult hypopituitary patients with GHD.Design, Setting, Patients, and ...
Zhang Xuting - - 2012
We performed a retrospective case review of stroke patients with diagnosis of hyperthyroidism admitted in our hospital from January 2008 to December 2010. We reviewed their routine assessments of intracranial and extracranial arteries or heart and then compared the demographic profiles, thryroid function test, and thyroid autoantibody status between stroke ...
Cocco Cristina - - 2012
Context. Although pituitary autoantibodies have frequently been reported in Autoimmune Polyendocrine Syndrome type 1 (APS1), the autoimmune involvement of the hypothalamic-pituitary axis remains to be elucidated. Objective. Our aim was to identify in APS1 patients novel autoantibodies, especially against hypothalamic-pituitary targets, and to correlate their presence with clinical features. Patients. ...
Bone Sarah L - - 2012
Objectives: To systematically evaluate auditory perceptual voice characteristics in people with thyroid disease prior to undergoing thyroid surgery. Patients and Methods: This study examined the auditory perceptual voice characteristics of 96 individuals with thyroid disease. Participants were categorised by type of thyroid disease (i.e. multinodular goitre, thyroid cancer, thyroid nodule, ...
Tomoda Chisato - - 2012
Background: Recently, we reported that the thyroglobulin (Tg) doubling time (DT) was the most potent prognostic factor in patients with papillary thyroid carcinoma (PTC) who underwent total thyroidectomy. Interestingly 16.2% of the study patients showed a decrease in Tg levels over time, giving negative values in Tg-DT. These patients showed an ...
Giuliani Cesidio - - 2012
Context:A functional thyroid-stimulating autoantibodies (TSAb) assay using a thyroid-stimulating hormone receptor chimera (Mc4) appears to be clinically more useful than the commonly used assay, a binding assay that measures all the antibodies binding to the thyroid-stimulating hormone receptor without functional discrimination, in diagnosing patient with Graves' disease (GD).Objective:The objective of ...
Brozzi Federica - - 2012
Background: the most important side effect of radioiodine (131I) therapy is sialoadenitis and xerostomy. Aim: to evaluate by ultrasound (US) parotid and submandibular glands after 131I therapy for differentiated thyroid cancer (DTC). Patients: 76 subjects thyroidectomised for DTC submitted to salivary glands US examination. Forty3 of them had been previously ...
Ramos Juliana Cristina Romero Rojas - - 2012
To characterize the phenotype of patients with congenital hypothyroidism (CH) due to dyshormonogenesis, and to hypothesize on the degree of genetic defect. Patients with dyshormonogenesis were subdivided into G1 (radioactive iodine uptake, RAIU > 15%; n = 62) and G2 (RAIU < 15%; n = 32). Thyroglobulin (TG) was measured ...
Vanderlei Felipe Augusto Brasileiro - - 2012
The purpose of this study was to evaluate if the measurement of peri-operative parathyroid hormone (PTH) is able to identify patients with increased risk of developing symptoms of hypocalcemia. Forty patients who underwent total thyroidectomy were studied prospectively. Ionized serum calcium and PTH were measured after induction of anesthesia, one ...
Vilallonga Ramon - - 2012
Primary hyperparathyroidism (PHPT) is not an uncommon endocrine disorder. However, acute primary hyperparathyroidism, or parathyroid crisis (PC), is a rare clinical entity characterized by life-threatening hypercalcemia of a sudden onset in patients with PHPT. We describe a patient with PC who presented with acute worsening of depressive symptoms, nausea and ...
Sonntag B - - 2012
In women, anti-Müllerian hormone (AMH) is exclusively expressed in granulosa cells and an established marker of ovarian reserve. In menstrual cycle disorders, low AMH is usually interpreted as an indicator of primary ovarian insufficiency. This study is a case series of 11 patients with hypopituitarism. AMH concentrations were on or ...
Murray Sara E - - 2012
Thyroid disease and hyperparathyroidism (HPT) are among the most common endocrine disorders, however, their association has not been well established. The aim of the present study was to determine the incidence of concomitant HPT in patients with thyroid disease requiring surgery, because a single definitive surgery should ideally be performed. ...
Gardner Chris J CJ Department of Obesity and Endocrinology, Clinical Sciences Centre, University of Liverpool, University Hospital Aintree, Longmoor Lane, Liverpool, - - 2012
Non-alcoholic fatty liver disease (NAFLD) is reported to be more common in patients with GH deficiency (GHD) than in the general population. we aimed to determine: i) liver fat in patients with GHD compared with age and body mass index (BMI)-matched controls; and ii) effect of 6 months of GH ...
Bogazzi Fausto - - 2012
Amiodarone-induced thyroid dysfunction occurs in 15-20% of amiodarone-treated patients. Amiodarone-induced hypothyroidism (AIH) does not pose relevant problems, is easily controlled by L-thyroxine replacement, and does not require amiodarone withdrawal. Most frequently AIH develops in patients with chronic autoimmune thyroiditis. Amiodarone-induced thyrotoxicosis (AIT) is most frequently due to destructive thyroiditis (type ...
Chen S-S - - 2012
Information concerning the clinical characteristics in elderly men with varicocoele is relatively limited. This study was assessed to evaluate the differences in clinical characteristics between young and elderly patients with varicocoele by retrospective chart review. Between June 2003 and February 2011, 169 young (18-30 years) men and 156 elderly (45-55 years) men ...
Steinhagen Emily - - 2012
PURPOSE: Patients with familial adenomatous polyposis (FAP) are at increased risk for colorectal cancer and extracolonic neoplasms. The prevalence of thyroid cancer (TC) and benign thyroid disease in this patient population is unclear, and guidelines for screening for TC in these patients are not well established. The purpose of this ...
van der Bruggen Wouter - - 2012
A 40-year-old patient had been analyzed because of a solitary nodule in the thyroid, including thyroid scintigraphy with TcO4 showing only slightly decreased uptake in the lower right lobe in an otherwise normal thyroid. Five years later, this patient presented with hyperthyroidism and a painful neck. This time thyroid scintigraphy ...
Karimi Mehran - - 2012
We aimed at evaluating the effect of long-term use of hydroxyurea (HU) on gonad function in patients with beta-thalassemia intermedia (beta-TI) in Iran. Seventy-five beta-TI patients aged ≥11 years, mean serum ferritin level of <1000 ng/dL in the recent 5 years, and taking HU with a dose of 8-15 mg ...
Saengsuda Yuthana - - 2012
The aim of the present study was to assess the accuracy of preoperative parathyroid localization using double phase planar 99mTc-methoxyisobutylisonitrile parathyroid scintigraphy (MIBI scintigraphy) in patients with primary hyperparathyroidism (pHPT) and secondary-tertiary hyperparathyroidism (stHPT) due to chronic renal failure. A retrospective study was conducted. Between 1995 and 2010, seventy-one patients ...
Mallick Salman - - 2012
Background: Erythropoiesis-stimulating agent (ESA) resistance remains incompletely understood among hemodialysis (HD) patients. Method: A retrospective, multicenter study was designed to analyze data from 1,934 patients followed for up to two years. The outcome measure was the erythropoietin resistance index (ERI), defined as erythropoietin dosage over a week divided by the ...
Mitchell Sabrina S Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA. - - 2012
Nutritional management is essential for patients with inborn errors of metabolism, such as urea cycle disorders (UCDs). Lack of appetite is common in these patients and can lead to underconsumption of calories, catabolism, and subsequently loss of metabolic control. The etiology of anorexia in these patients is largely unexplored. The ...
Mohamed Miski - - 2012
Glycoproteins are essential in the production, transport, storage and regulation of thyroid hormones. Altered glycosylation has a potential impact on thyroid function. Abnormal thyroid function tests have been described in patients with congenital disorders of glycosylation. We evaluated the reliability of biochemical markers and investigated thyroid function in 18 PMM2-CDG ...
Pappa Theodora - - 2012
Approximately 10% of hypertensives are considered to exhibit autonomous aldosterone secretion (AAS). Although adrenal incidentalomas (AI) can be found in up to 19% of hypertensive individuals, data on the incidence of AAS in hypertensive patients with AI remain scarce. The aim was to study adrenal aldosterone (ALD) secretory pattern in ...
Pascual Corrales Eider - - 2012
OBJECTIVE: Risk factors for differentiated thyroid carcinoma (DTC) are poorly understood, but serum TSH levels, thyroid nodularity, and presence of autoimmunity are well-recognized factors that modulate DTC prevalence. TSH stimulates proliferation of both normal and neoplastic follicular cells. Consequently, thyroid-stimulating immunoglobulins (TSI), because of its TSH-like action, should induce DTC ...
Diazzi Chiara - - 2012
Propylthiouracil (PTU) therapy is associated with a variety of adverse reactions, among the most rare being interstitial pneumonia. To date, this has been reported in four Asian patients with autoimmune hyperthyroidism. Here we describe a Caucasian woman who developed a bronchiolitis obliterans organizing pneumonia (BOOP)-like interstitial pneumonia after PTU administration ...
Oh Min Chul - - 2012
Object The purpose of this study was to assess factors associated with intracranial aneurysm (IA) in patients with pituitary adenoma (PA). In addition, these patients were compared with a control group from the general patient population in terms of the age-matched prevalence rate and the pattern of distribution of IA. ...
Fanti P A - - 2012
Literature data have suggested an increase of incidental thyroid nodules in patients with malignancies, including melanoma. The ultrasound findings of 168 consecutive melanoma patients were revisited in order to evaluate the presence of incidental thyroid nodules and the results were compared with clinical features, Breslow thickness and the rate of ...
Ban Ee Jun - - 2012
Background:  The histological characteristics of follicular thyroid carcinomas (FTCs) are important predictors of prognosis, and lesions can be classified as either minimally invasive follicular carcinoma (MIFC) or widely invasive follicular carcinoma (WIFC) based on histopathological characteristics. There has been controversy surrounding the histological classification of FTC, which can present challenges ...
Vrachimis A - - 2012
Aim: Radioiodine remnant ablation (RRA) after (near-)total thyroidectomy (TE) is a key element in patients with differentiated thyroid cancer (DTC). The use of exogenous TSH stimulation (rhTSH) prior to RRA has shown promising results as compared to conventional thyroid hormone withdrawal (THW). As yet, the efficacy of RRA after brief ...
Muchow Ryan D - - 2012
The trend of increasing cervical spine multidirectional computed tomography (MDCT) imaging of pediatric trauma patients is characteristic of the overall dramatic increase in computed tomography utilization in the United States. The purpose of this study is to compare the amount of radiation a pediatric trauma patient absorbs to the thyroid ...
Wildemberg Luiz Eduardo Armondi - - 2012
Objectives: to describe two patients who developed pituitary apoplexy during the course of dengue hemorrhagic fever (DHF).Methods: case report.Results: the first case was a 40-year-old male who developed clinical signs and symptoms of dengue, which was confirmed by serologic exam. He presented with thrombocytopenia and developed severe headache and vomiting. ...
Hána V - - 2012
Relatively frequent pituitary hormone deficiencies are observed after traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH) and according to the published studies the neuroendocrine consequenses of traumatic brain injury are underdiagnosed. In a cohort of 59 patients (49 males, mean age 68.3 years, 36-88 years) after evacuation of subdural hematoma ...
Imbriano Louis J - - 2012
Background: Reset osmostat (RO) occurs in 36% of patients with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and is not often considered when evaluating hyponatremic patients. Patients with RO are not usually treated, but recent awareness that symptoms are associated with mild hyponatremia creates a therapeutic dilemma. We encountered patients ...
Lin Yen-Chung - - 2012
The population of uremia patients receiving long-term peritoneal dialysis (PD) is growing, and abnormal thyroid function occurs increasingly in patients with chronic kidney disease in comparison with the normal population. We aimed to elucidate the clinical impact of abnormal thyroid function in long-term PD patients. This was a retrospective, case-controlled, ...
Law Ryan - - 2012
Current endoscopic pancreatic function test (ePFT) methods use either secretin or cholecystokinin (CCK) to measure pancreatic function. To evaluate a novel ePFT protocol that includes both secretin and CCK stimulation and to assess which fluid parameters best discriminate patients with chronic pancreatitis (CP). Prospective, cross-sectional diagnostic study. Single, tertiary-care institution. ...
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