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Denniston Alastair K AK *Department of Ophthalmology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; †Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom; ‡Birmingham and Midland Eye Centre, Sandwell and West Birmingham NHS Trust, Birmingham, United Kingdom; §Institute of Child Health, University College London, London, United Kingdom; and ¶Birmingham Women's NHS Foundation Trust, Birmingham, United - - 2014
To assess the visual needs of the adult population with Bardet-Biedl syndrome (BBS) and to ensure that this is addressed by a national Bardet-Biedl Service. A cross-sectional analysis of all adults under a national BBS Clinic (Birmingham, United Kingdom) was performed using the BBS Ophthalmic Assessment Tool, a novel tool ...
Virchow J Christian JC University Clinic Rostock, Zentrum f. Innere Medizin, Department of Pulmonology, Intensive Care Medicine, Klinik I , Rostock , Germany - - 2014
Background: Many patients with asthma and chronic obstructive pulmonary disease (COPD) symptoms remain insufficiently controlled despite inhalation treatment, with poor inhaler technique recognized as a significant contributor. Dry powder inhalers (DPIs) need less coordination of actuation and inspiration than pressured metered dose inhalers. Objectives: To assess whether consideration of 'ideal ...
Zanon Ezio E Department of Cardiac, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua, Italy. Electronic address: - - 2014
Studies providing information about the cognitive profile of adult haemophiliacs are lacking. To assess the neuropsychological profile in a group of Haemophiliac patients; to detect asymptomatic cerebral microbleeds (CMBs) and any correlation between CMBs and cognitive dysfunctions; to verify how several contributing factors may determine cognitive dysfunctions and/or Magnetic Resonance ...
Singh Namrata - - 2014
Patients with systemic lupus erythematosus (SLE) have an abnormal population of neutrophils, called low density granulocytes (LDGs), that express the surface markers of mature neutrophils, yet their nuclear morphology resembles an immature cell. Because a similar discrepancy in maturation status is observed in myelodysplasias, and disruption of neutrophil development is ...
Wang Yudong Y State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, ChinaDepartment of Medicine, The University of Hong Kong, Hong Kong, - - 2014
Type 1 diabetes (T1D) is an autoimmune disease resulting from self-destruction of insulin-producing β cells. Reduced neutrophil counts have been observed in patients with T1D. However, the pathological roles of neutrophils in the development of T1D remain unknown. Here we show that circulating protein levels and enzymatic activities of neutrophil ...
Shigemura Tomonari T Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, 390-8621, - - 2014
Neutrophil-specific granule deficiency (SGD) is a rare, congenital disorder characterized by atypical neutrophil structure and function that results in frequent and severe bacterial infections. However, the clinical course of patients with SGD have not been described in detail because of the scarcity of the disease. We present the clinical course ...
Ishibashi Masafumi M *Department of Dermatology, Saiseikai Central Hospital, Tokyo, Japan; †Department of Dermatology, Nippon Kokan Hospital, Kawasaki, Japan; and ‡Department of Dermatology, Keiyu Hospital, Yokohama, - - 2014
The diverse histopathologic spectrum of cutaneous vasculitis in eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) has not been well described. Fifteen skin biopsy specimens from 9 EGPA patients with histopathologically proven necrotizing vasculitis were reviewed clinicopathologically. Among 8 patients with dermal small vessel vasculitis, neutrophilic vasculitis was observed in 2 ...
Taylor N J NJ Liver Intensive Care Unit, King's College London School of Medicine at King's College Hospital, London, UK; Institute of Liver Studies and Transplantation, King's College London School of Medicine at King's College Hospital, London, - - 2014
Patients with cirrhosis are susceptible to sepsis, pre-disposing to the development of encephalopathy, bleeding and organ dysfunction with associated high mortality. To characterise circulating neutrophil function in a cirrhotic cohort as a determinant of 90-day and 1-year mortality. Sixty-two patients with cirrhosis [49 stable (Child-Pugh A/B/C = 24%/39%/37%); 13 acute-on-chronic liver failure] ...
Thiele Gabriela Bicca GB Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, - - 2014
Spontaneous bacterial peritonitis (SBP) is a severe complication that occurs in 8-27% of hospitalized patients with liver cirrhosis and ascites, with high mortality rates. This study aimed to identify the clinical characteristics associated with SBP. Cross-sectional study, conducted in a public university. The study consecutively included individuals with liver cirrhosis ...
Moosani Anita A Staff Pediatric Dentist, Department of Dentistry, Holland Bloorview Kids Rehabilitation Hospital, Toronto, MSc Pediatric Dentistry Graduate, Faculty of Dentistry, University of Toronto, Former Dental Resident, Department of Dentistry, Mount Sinai Hospital, Toronto, Ontario, - - 2014
The purpose of this study was to validate and assess the feasibility of using an assay of oral neutrophils to measure periodontal inflammation in uncooperative adults with special needs. Conventional periodontal measurements and neutrophil counts obtained from oral swabs were performed on patients having dental care under general anesthesia (GA) ...
Pohl Kerstin K Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Dublin, - - 2014
Studies have endeavoured to reconcile whether dysfunction of neutrophils in people with cystic fibrosis (CF) is as a result of the genetic defect or secondary due to infection and inflammation. In this study we illustrate that disrupted function of the CF transmembrane conductance regulator (CFTR), such as that which occurs ...
Naseem Arshad A Department of Pulmonology, Military Hospital, - - 2014
Objective: To determine the frequency of sputum neutrophilia in patients with severe persistent bronchial asthma. Study Design: A cross-sectional study. Place and Duration of Study: Department of Medicine, Military Hospital, Rawalpindi, from November 2009 to November 2010. Methodology: Cases of severe persistent bronchial asthma, aged between 12 and 40 years, ...
Kazama Hiroshi H Department of Haematology, Tokyo Women's Medical University, Tokyo, - - 2014
Myelodysplastic syndromes (MDS) are heterogeneous clonal disorders characterized by cytopenias that arise due to ineffective haematopoiesis and morphological dysplasia and carry an increased risk of incident acute myeloid leukaemia. The pathogenesis of marrow dysfunction in MDS is multifactorial and consistent with a multistep model and may lead to heterogeneity of ...
Gacouin Arnaud A a CHU Rennes, Maladies Infectieuses et Réanimation Médicale, F-35033 Rennes, France b Inserm-CIC-F-35043 Rennes, France c Univ Rennes 1, Faculté de Médecine, Biosit, F-35043 Rennes, France d CHU Rennes, Laboratoire d'Hématologie, F-35033 Rennes, France e Inserm U 917, Rennes, - - 2014
Acute and massive alcohol exposure (blood alcohol concentration of 1 g/l or higher) is a widely way to consume alcohol. In a prospective study performed in critically ill nontrauma patients we compared C-Reactive Protein (CRP) values, circulating subsets of white blood cells (WBC) and neutrophils CD64 indexes recorded at admission ...
Minar Phillip P 1Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Divisions of 2Allergy and Immunology and 3Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; 4Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; 5Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; 6Division of Pediatric Gastroenterology and Nutrition, Cohen Children's Medical Center of New York, New Hyde Park, New York; 7Department of Pediatric Gastroenterology and Nutrition, Goryeb Children's Hospital/Atlantic Health System, Morristown, New Jersey; 8Division of Pediatric Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio; 9Department of Pediatrics, University of California, San Francisco, San Francisco, California; 10Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada; 11Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; 12Digestive Diseases and Nutrition Center, Department of Pediatrics, University at Buffalo, Buffalo, New York; 13Division of Digestive Diseases and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut; and 14Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University, Atlanta, - - 2014
Neutrophil expression of the Fcγ receptor I (CD64) is upregulated in adult patients with clinically active inflammatory bowel disease (IBD). We tested the relationship of CD64 with mucosal inflammation and clinical relapse in pediatric Crohn's disease (CD). In a cohort of 208 newly diagnosed CD and 43 non-IBD controls, ileal ...
Keskin Kurt Raziye R Department of Obstetrics and Gynecology, Mustafa Kemal University Medical School, Hatay, 31100, Turkey, - - 2014
Previous studies have shown increased inflammatory activity in patients with polycystic ovary syndrome (PCOS); however, it remains uncertain whether this increased inflammatory activity is a consequence of the disorder itself or of the accompanying obesity. We therefore aimed to test the inflammatory marker levels in obese and lean patients with ...
Milara Javier J Clinical Research Unit (UIC), University General Hospital Consortium, Valencia; Department of Biotechnology, Universidad Politécnica de Valencia; Research Foundation of General Hospital of Valencia. Electronic address: - - 2014
Glucocorticoid functions are markedly impaired in patients with chronic obstructive pulmonary disease (COPD). The phosphodiesterase 4 inhibitor roflumilast N-oxide (RNO) is the active metabolite of roflumilast approved as a treatment to reduce the risk of exacerbations in patients with severe COPD. We sought to characterize the differential effects of RNO ...
Marino Franca - - 2014
Neutrophil (PMN) leukocytes participate to the initial phases of atherosclerosis through the release of Interleukin 8 (CxCL8; IL-8) that contribute to amplification of inflammation. Aim of the study is to investigate the production of IL-8 by PMN leukocytes from dyslipidemic patients treated with simvastatin. In 15 dyslipidemic subjects with moderately ...
Folyovich András - - 2014
Acute ischemic stroke (AIS) has a biphasic effect on the peripheral immune system. The initial inflammatory response is followed by systemic immunosuppression, referred to as stroke-induced immunosuppression (SIIS), leading to severe complications in stroke patients. We aimed to identify an inflammatory marker that best represents this biphasic immunological response after ...
Fernandez-Botran Rafael R Department of Pathology & Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY, - - 2014
The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (PSI ≥ 91 points). Blood and sputum samples ...
Ohlsson Susanne M SM Department of Nephrology, Lund University, Lund, - - 2014
Anti-neutrophil cytoplasmic antibodies (ANCA) are thought to be pathogenic in ANCA associated vasculitis (AAV) by stimulating polymorphonuclear leukocytes (PMNs) to degranulate and produce reactive oxygen species (ROS). The aim of this study was to investigate if PMNs from AAV patients are more readily stimulated by ANCA compared with PMNs from ...
Avci Anil A Cardiology Deparment, Kartal Koşuyolu Heart Research and Training Hospital, Istanbul, - - 2014
The role of inflammation in fibrotic and calcific processes of atherosclerosis and aortic stenosis (AS) is similar. Furthermore, a relationship between systemic inflammation and heart failure has been well demonstrated. Recently, neutrophil/lymphocyte ratio (NLR) has been proposed as a predictive marker of systemic inflammation. We investigated the association of NLR ...
Tsushima Kenji K First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto Nagano 390-8621 Japan; Department of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku Chiba 260-8670 Japan. Electronic address: - - 2014
Noninvasive ventilation (NIV) can reduce the need for invasive mechanical ventilation. The aim of this investigation was to determine whether the combination of NIV with administration of a neutrophil elastase inhibitor could improve outcome and respiratory conditions in acute respiratory distress syndrome (ARDS)-patients, according to the Berlin definition. ARDS-patients were ...
Yalcin Ahmet Arif - - 2014
We aimed to investigate the association between the neutrophil-lymphocyte ratio (NLR) and coronary artery ectasia (CAE). The study included 198 patients who had undergone coronary angiography for suspected coronary artery disease (CAD). The patients were divided into the following 4 groups: group 1, 44 patients with normal coronary arteries; group ...
Yurtdaş Mustafa M Department of Cardiology, Van Region Training and Research Hospital, Van, - - 2014
Systemic inflammation beyond the skin may provide an explanation of the increased cardiovascular risk observed in psoriasis. It was hypothesized that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are potential predictors of subclinical atherosclerosis measured by aortic velocity propagation (AVP) and carotid intima-media thickness (CIMT) in psoriasis. Fifty-one patients with ...
Mook-Kannamori Barry B BB Department of Neurology, Academic Medical Center, Center of Infection and Immunity Amsterdam (CINIMA), The - - 2014
Recent research into the treatment of bacterial meningitis has examined the innate immune system, specifically the complement system, as a potential target for adjuvant therapy. However, the effects of blocking the complement system may be pathogen dependent. We measured cerebrospinal fluid (CSF) levels of complement components C1q, C3a, iC3b, C5a, ...
Lippi Giuseppe - - 2014
Acute bacterial meningitis is a rare but extremely severe disease. The aim of this study was to investigate whether neutrophil gelatinase-associated lipocalin (NGAL) is present and measurable in cerebrospinal fluid (CSF) and if its assessment may be useful for identifying patients with bacterial meningitis. Eligible specimens were all consecutive CSFs ...
Lenglet Sébastien S Division of Cardiology, Department of Internal Medicine, Foundation for Medical Researches, University of Geneva, 64 Avenue de la Roseraie, 1211 Geneva, - - 2014
Systemic and intraplaque biomarkers have been widely investigated in clinical cohorts as promising surrogate parameters of cardiovascular vulnerability. In this pilot study, we investigated if systemic and intraplaque levels of calcification biomarkers were affected by treatment with a statin in a cohort of patients with severe carotid stenosis and being ...
Cooper Chad J CJ Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, - - 2014
Background Cyclic vomiting syndrome (CVS) in adults is a disorder characterized by recurrent and stereotypic episodes of severe nausea, vomiting and abdominal pain separated by symptom-free intervals. Our goal was to investigate gastric emptying (GE) in CVS patients. Material and Methods This was a retrospective study of 30 adult patients ...
Polańska Bożena - - 2013
Peritoneal dialysis is one of the main modality of treatment in end-stage kidney diseases (ESKD) in children. In our previous work in chronic kidney disease patients, in pre-dialyzed period and on hemodialysis, the neutrophils were highly activated. The aim of this study was to assess an inflammatory condition and neutrophil ...
Tzvetanov Plamen P Department of Neurosciences, University Hospitals, Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, - - 2014
Background and objective A correlation between the levels of antibodies to alpha-elastin (alpha-AEAb) and tropoelastin (tropo-AEAb) and the corresponding peptide concentration is found in human serum in health and disease. Serum elastin peptide and anti-elastin antibodies (AEAb) levels are age-related and vary with the stages of atherosclerotic vascular damage. This ...
Kaplan Onder - - 2013
Primary dysmenorrhea is a common inflammatory disease with an uncertain pathogenesis, although one consistent finding is increased neutrophil activity. We aimed to investigate the effects of a non-steroidal anti-inflammatory drug (NSAID) on oxidative stress and Ca(2+) levels in neutrophils from patients with primary dysmenorrhea. Blood samples were obtained for neutrophil ...
Yildiz Abdulkadir - - 2013
Inflammation has recently emerged in the pathogenesis of several cardiovascular disorders, including arrhythmias. The neutrophil-lymphocyte ratio (NLR) is a simple marker for the assessment of inflammatory status. Therefore, we aimed to investigate the relationship between the NLR and the ventricular premature contraction (VPC) existence. Patients aged between 18 and 40 ...
Bhansali Rahul S RS Department of Dentistry, Dr. Ulhas Patil Medical College and Research Center, Jalgaon, Maharashtra, - - 2013
Localized aggressive periodontitis (LAP) patients exhibit abnormal neutrophil functions to a variety of environmental and host stimuli. The aim of the present study was to evaluate neutrophils chemotaxis, phagocytosis, microbicidal activity and superoxide generation in LAP patients of Indian origin. Eleven LAP patients and nine healthy subjects were included in ...
Patil Kavita Gangaram KG Associate Professor, Department of Microbiology, Institute of Medical Sciences , Mayani, District, Satara, Maharashtra, India - - 2013
A higher prevalence of periodontal disease among areca nut chewers than non chewers has been demonstrated. Neutrophils, the first line of defence mechanism against microbial infection play an important role in maintaining the periodontal health. In this context our aim was to evaluate the effects of areca nut extracts on ...
Park Sang Hyuk - - 2013
The Beckman Coulter CytoDiff flow cytometric system (Beckman Coulter, Miami, FL) was recently developed for performing leukocyte differential counts in up to 16 leukocyte subpopulations. We compared these leukocyte subpopulation levels among patients with three stages of sepsis (uncomplicated sepsis, severe sepsis, septic shock), especially focused on the discrimination of ...
Park Sang Hyuk - - 2013
Background: The Beckman Coulter CytoDiff flow cytometric system (Beckman Coulter, Miami, FL, USA) was recently developed for performing leukocyte differential counts in up to 16 leukocyte subpopulations. We compared these leukocyte subpopulation levels among patients with three stages of sepsis (uncomplicated sepsis, severe sepsis, septic shock), especially focused on the ...
Sönmez Osman - - 2013
The neutrophil -to- lymphocyte ratio (NLR) is a new predictor for cardiovascular risk and mortality. The SYNTAX score is an angiographic tool used in grading the complexity of coronary artery disease (CAD). However, its relation with CAD severity and complexity is not yet known. We hypothesized that NLR would be ...
Vaitkus Mindaugas - - 2013
Chronic airway inflammation can be mediated by an enhanced neutrophil oxidative burst. However, the role of bacteria in the pathogenesis of chronic obstructive pulmonary disease (COPD) exacerbations is highly controversial. The aim of this study was to evaluate the production of reactive oxygen species (ROS) in peripheral blood and sputum ...
Hotz C - - 2013
Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction characterized by rash with sterile pustules, high fever and elevated circulating neutrophil counts. To investigate the frequency and clinical features of AGEP systemic involvement. Methods This retrospective study included all patients hospitalized in our department between 2000 and 2010 ...
Chiang Chi-Huei - - 2013
Whether guideline-oriented pharmacotherapy prevents the decline in pulmonary function or reduces systemic inflammation associated with chronic obstructive pulmonary disease (COPD) is uncertain. The aim of this study was to assess the outcome of COPD in clinical practice under real-world conditions in Taiwan as measured by pulmonary function and systemic inflammation ...
Ikeda Katsuhisa - - 2013
OBJECTIVES/HYPOTHESIS: Japanese patients with chronic rhinosinusitis with nasal polyps (CRSwNP), differing from European and U.S. patients, are suggested to show two distinct phenotypes: Th2-polarized and Th1-shifted immunity. The purpose of this study was to conduct clinical subgrouping of CRSwNP based on inflammatory cell infiltration, which was evaluated and supported by ...
Shema-Didi Lilach - - 2013
The hemodialysis (HD) procedure induces oxidative stress (OS), which is further aggravated by intravenous (IV) iron administration, aimed at correcting anemia of patients with HD. We have recently shown that 1 year of pomegranate juice (PJ) intake attenuated OS and inflammation in patients with HD. In the current study, we ...
McCarty Hollyn M HM Arkansas Children's Hospital, Little Rock, AR, - - 2013
Cardiovascular abnormalities in Williams syndrome (WS) are largely attributable to elastin haploinsufficiency resulting from a large deletion of the elastin-containing region on chromosome 7q11.23. The risk of sudden death in patients with WS is 25- to 100-fold greater than that in the general population. The corrected QT (QTc) interval is ...
Pepper Ruth J RJ UCL Centre for Nephrology, Royal Free Hospital, London, UK. - - 2013
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory conditions. By immunohistochemistry of renal biopsies, patients with focal or crescentic glomerular ...
Kontoyiannis Dimitrios P DP Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. - - 2013
We examined the qualitative polymorphonuclear neutrophil (PMN)-associated immune impairment in patients with chronic lymphocytic leukemia (CLL) by characterizing phagocytic killing of key non-opsonized bacterial (Staphylococcus aureus and Pseudomonas aeruginosa) and fungal (Candida albicans and Aspergillus fumigatus) pathogens. Neutrophils were collected from 47 non-neutropenic patients with CLL (PMN count > 1000/mm(3)) ...
Favot C L - - 2013
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) occurs subsequent to intravenous and oral bisphosphonate exposure in a small subset of patients. The identification of the pathophysiologic mechanisms has not been fully elucidated. Evidence of concurrent bacterial colonization at sites of bone necrosis, previous reports of neutrophil-related complications in some patients taking ...
Gupta Vandana - - 2013
Abstract Neutrophils are central to the pathogenesis of COPD, releasing a range of pro-inflammatory and tissue destructive mediators. Sputum neutrophil numbers are elevated in COPD patients compared to healthy controls. We critically appraise the potential of sputum neutrophils as a biomarker in COPD. We show that there is insufficient evidence ...
Bartoli Maria Laura - - 2013
Abstract Context: It is well known that ozone exposure decreases lung function and increases airway neutrophilia, but large variability has been observed among asthmatic patients. Objective: To find possible predictors of functional and inflammatory airway response to ozone in asthmatic patients. Materials and methods: We studied 120 patients with mild-to-moderate ...
Wang Jingwei - - 2013
BACKGROUND: Leukocytes number in the circulation plays a central role in inflammatory diseases, such as coronary heart disease (CHD). Increased counts are correlated with the intensity of the peri-infarction inflammatory response and adverse outcomes. We investigated leukocyte and leukocyte subset counts in dyslipidaemia patients and their relationship with LDL oxidation. ...
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