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Kilicarslan Rukiye R Department of Radiology, Bezmialem Vakif University School of Medicine, Istanbul, - - 2014
Objectives: We examined brain diffusion changes of acromegalic patients. We searched whether there are the differences in ADC and FA values between remission and non-remission acromegalic patients and investigated any effect of time of hormone exposure on diffusion metrics. Methods: The values of FA and ADC were calculated in total ...
Nguyen Frederic N FN Department of Neurology, UT Health, University of Texas Medical School, Houston, TX, - - 2014
Acute hypokalemic paralysis is characterized by muscle weakness or paralysis secondary to low serum potassium levels. Neurogenic diabetes insipidus (DI) is a condition where the patient excretes large volume of dilute urine due to low levels of antidiuretic hormone. Here, we describe a patient with neurogenic DI who developed hypokalemic ...
Shibli-Rahhal A A Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA, - - 2014
Although 25 hydroxyvitamin D (25OHD) and parathyroid hormone (PTH) levels are inversely related, less than half of the patients with a low vitamin D level have an elevated PTH, and, in most of these patients, the PTH does not immediately normalize with correction of the vitamin D. Despite the inverse ...
Chow Kai Ming KM Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong - - 2014
Although calcimimetics cinacalcet can reduce parathyroid hormone level and control secondary hyperparathyroidism in end-stage renal disease patients, risk of vascular calcification remains high. Whether cinacalcet can further reduce vascular damage or arterial stiffness is unknown. We studied the effect of cinacalcet in 33 peritoneal dialysis patients with inadequately controlled secondary ...
Carnevale Vincenzo V Unit of Internal Medicine, "Casa Sollievo della Sofferenza" Hospital, IRCCS, Viale dei Cappuccini snc, 71013, San Giovanni Rotondo, FG, Italy, - - 2014
Vitamin D (25OHD) and/or parathyroid hormone (PTH) levels have been associated with common carotid intima-media thickness (IMT). We investigated such associations in inpatients consecutively admitted to an Internal Medicine Department. In 168 consecutive patients admitted to our department, 25 hydroxyvitamin D (25OHD) was measured by means of RIA and PTH ...
Karadag Serhat - - 2014
Many markers have been proposed for CVD risk assessment in dialysis population. Apelin is a peptide that has roles in cardiovascular functions and volume regulation namely vasodilation, decreased blood pressure (BP), positive inotropic effect and inhibition of antidiuretic hormone release. The aim of this study was to examine relationship of ...
Chowdhury Sudipta Dhar SD Department of Gastrointestinal Sciences, Christian Medical College, Vellore, 632 004, India, - - 2014
Primary hyperparathyroidism is a rare cause of acute pancreatitis. Five consecutive patients with acute or recurrent acute pancreatitis and primary hyperparathyroidism were included. All patients had elevated serum calcium on admission and high levels of circulating parathyroid hormone. Both ultrasonography and Sestamibi scan was used to localize parathyroid adenoma. Except ...
Woolley Josh D JD From the Departments of Psychiatry (J.D.W.), Physiology (M.D.), and Neuroscience (M.D.), and Department of Neurology, Memory and Aging Center (B.K.K., A.N., A.K., B.L.M., K.P.R.), University of California, San Francisco; Department of Psychiatry (J.D.W.), San Francisco Veterans Affairs Medical Center; and Departments of Molecular Biosciences and Nutrition (P.H.), School of Veterinary Medicine, University of California, - - 2014
To investigate whether patients with behavioral variant frontotemporal dementia (bvFTD) have dysregulation in satiety-related hormonal signaling using a laboratory-based case-control study. Fifty-four participants (19 patients with bvFTD, 17 patients with Alzheimer disease dementia, and 18 healthy normal controls [NCs]) were recruited from a tertiary-care dementia clinic. During a standardized breakfast, ...
Stagi Stefano S Department of Health's Sciences, Paediatric Endocrinology Unit, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy. - - 2014
Trisomy 9p is an uncommon anomaly characterised by mental retardation, head and facial abnormalities, congenital heart defects, kidney abnormalities, and skeletal malformations. Affected children may also show growth and puberty retardation with delayed bone age. Auxological and endocrinological data are lacking for this syndrome. We describe three girls and one ...
Celec P P Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia, - - 2014
Continuous positive airway pressure (CPAP) improves symptoms in patients with obstructive sleep apnea syndrome (OSAS). It is currently unclear, whether CPAP also alters endocrine parameters such as sex hormone levels. In a previous study, we have found no changes in sex hormones in patients with OSAS after one night with ...
Popowicz Bożena - - 2014
The aim of this investigation was to assess the usefulness of the measurement of PTH concentration in the material obtained during FNAB (PTH-FNAB) in the identification of pathological parathyroids in patients with frequently coexisting thyroid abnormalities (nodular goitre, chronic thyroiditis, previous thyroidectomy). Additionally, the influence of the size of goitre, ...
Ryder Mabel M Human Oncology and Pathogenesis Program, Department of Medicine Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York, USA Weill Cornell Medical College, New York, New York, - - 2014
Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab induces symptomatic, sometimes severe, endocrine immune-related adverse events (irAEs) that are inconsistently recognized and reported. The objective of this review was to comprehensively characterize the incidence, presentation, and management ...
- - 2013
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders found in women of reproductive age. Differences in hormonal and metabolic profiles are observed in groups of patients with normal and elevated BMI. Cause of disturbances observed in the two groups of patients with PCOS is analyzed. The ...
Bomba Monica M Clinic of Child and Adolescent Mental Health, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy. Electronic address: - - 2013
Aim of this study consisted in assessing the 24-h heart rate variability (HRV), a measure of autonomic nervous system (ANS) imbalance, in 21 adolescents with functional hypothalamic amenorrhea (FHA, 11 normogonadotropic, N-FHA, and 10 hypogonadotropic, Hy-FHA) compared to 21 patients with anorexia nervosa (AN) and 21 controls. As expected, subjects ...
Tepel Martin - - 2013
Background:It was shown that nonoxidized PTH (n-oxPTH) is bioactive, whereas oxidized PTH at methionine residues results in loss of biological activity.Methods:In this study we analyzed the association of n-oxPTH on mortality in hemodialysis patients using a recently developed assay system.Results:Hemodialysis patients (224 men, 116 women) had a median age of ...
Macfarlane David P DP Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, Dundee, - - 2013
Primary hyperparathyroidism, a disorder in which there is a tendency for hypercalcaemia caused by autonomous overproduction of parathyroid hormone, is common, especially in postmenopausal women. Although parathyroidectomy is indicated for symptomatic patients, most individuals with the disorder are asymptomatic and without classic complications, such as renal stones and osteoporosis, at ...
Korovin Lev N - - 2013
The purpose of this study was to determine if laterality of internal jugular vein (IJV) sampling affects the accuracy of intraoperative parathyroid hormone (PTH) monitoring during parathyroidectomy for primary hyperparathyroidism. In this study, 109 patients underwent parathyroidectomy (82 with unilateral disease, 27 with multigland disease). PTH samples were taken from ...
Blum Werner F - - 2013
We assessed characteristics of children initially diagnosed with idiopathic isolated GH deficiency (IGHD) who later developed additional pituitary hormone deficiencies (MPHD). Data were analyzed for 5805 pediatric patients with idiopathic IGHD, who were GH-naïve at baseline and GH-treated in the multinational observational Genetics and Neuroendocrinology of Short Stature International Study ...
Mir Shahnaz Ahmad SA Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, - - 2013
Literature is inconsistent whether patients with hypopituitarism have increased risk of thrombosis. Recent data has shown problems with the coagulation system in Sheehan's syndrome (SS). Here, we describe a case of SS which presented with deep vein thrombosis. To describe a case of SS presenting as deep vein thrombosis. A ...
Maheshwari Rushikesh R Department of Endocrinology and Metabolism, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, - - 2013
Visual disturbance as a presenting feature of pseudohypoparathyroidism (PHP) is uncommon. Although papilledema is commonly reported with hypoparathyroidism primary or secondary, but not reported commonly with PHP. A 10-year-old male child presented to our outpatient service with the complaints of blurring of vision, diplopia, and associated headache. There was no ...
Costantini Antonio A 1 Department of Neurological Rehabilitation, Clinic Villa Immacolata , Viterbo, Italy - - 2013
Abstract Objectives: In a previous study on fatigue and related disorders in inflammatory bowel disease (IBD), we observed that IBD patients improved after treatment with high-dose thiamine. We hypothesized that the chronic fatigue accompanying inflammatory and autoimmune diseases is the clinical manifestation of a mild thiamine deficiency that is probably ...
Lasmar Bernardo P - - 2013
To assess the correlation between the size of endometrial polyps and the histopathologic diagnosis of hyperplasia or cancer. A retrospective study was conducted using databases of the outpatient clinic at Antonio Pedro University Hospital in Niterói, Brazil, and of a private hysteroscopy service. The analysis included 1136 asymptomatic patients with ...
Miljic D - - 2013
Cardiovascular morbidity in adult patients with growth hormone deficiency (GHD) and hypopituitarism is increased. Clustering of cardiovascular risk factors leading to endothelial dysfunction and impaired fibrinolysis has also been reported and may account for progression to overt vascular changes in these patients. However, effect of long lasting GH replacement therapy ...
Riss Philipp - - 2013
Increased intraoperative parathyroid hormone excretion ("PTH spikes") due to unintended manipulation of parathyroid adenoma can be observed frequently during surgery for primary hyperparathyroidism. This may lead to difficulties in interpreting intraoperative PTH curves. The aim of this study was to elucidate possible risk factors for PTH spikes and to evaluate ...
Coulibaly G - - 2013
Introduction. Meeting treatment targets for dialysis is a seemingly impossible challenge for most countries of sub-Saharan Africa. To assess this problem, we conducted this study of mineral and bone disorders in subjects undergoing hemodialysis at the Ouagadougou hemodialysis unit, the only such unit in Burkina Faso. Patients and methods. This ...
Nilubol Naris - - 2013
BACKGROUND: Intraoperative parathyroid hormone monitoring (IOPTH) is a widely used adjunct for primary hyperparathyroidism (pHPT). However, the benefit of IOPTH in familial pHPT, such as in multiple endocrine neoplasia type I (MEN1), remains unclear. METHODS: We performed a retrospective analysis of 52 patients with MEN1-associated pHPT undergoing initial parathyroidectomy with ...
Deal Cheri - - 2013
Background/Aims: Magnetic resonance imaging (MRI) is used to investigate the etiology of growth hormone deficiency (GHD). This study examined relationships between MRI findings and clinical/hormonal phenotypes in children with GHD in the observational Genetics and Neuroendocrinology of Short Stature International Study, GeNeSIS. Methods: Clinical presentation, hormonal status and first-year GH ...
Schneider David F - - 2013
BACKGROUND: Using minimally invasive parathyroidectomy (MIP), most surgeons require a 50% decline in intraoperative parathyroid hormone (IoPTH) to determine cure, but the significance of IoPTH kinetics occurring after this drop remains unknown. The aim of this study was to determine the impact of IoPTH levels that first meet criteria for ...
Correa Livia L - - 2013
Introduction: Published data suggest that patients with acromegaly have an increased prevalence of prostate disorders. Objective: To evaluate prostatic disorders in acromegalic patients comparing these results after one year of treatment of acromegaly and with a group of healthy men. Materials and Methods: This study was composed of two parts: ...
Zimmerman Deborah L DL Division of Nephrology, Kidney Research Centre of the Ottawa Hospital Research Institute, Division of Nephrology, University of Ottawa, Ottawa, Ontario, Canada. - - 2013
Patients treated with conventional hemodialysis (HD) develop disorders of mineral metabolism that are associated with increased morbidity and mortality. More frequent and longer HD has been associated with improvement in hyperphosphatemia that may improve outcomes. Systematic review and meta-analysis to inform the clinical practice guideline on intensive dialysis for the ...
Moura Neto A - - 2013
Alterations in thyroid hormone levels are found associated with inflammation in patients with non-thyroidal illness (NTIS) and are common in patients with type 2 diabetes mellitus (T2DM). Inflammation has also been linked with development of cardiovascular events (CVE) in T2DM. Our objective was to assess whether thyroid hormone abnormalities typical ...
Abdelghani Ramsy - - 2013
OBJECTIVES/HYPOTHESIS: We aimed to study the diagnostic value of parathyroid hormone (PTH) concentration in the needle washout of fine-needle aspiration (FNA) compared to cytology of suspicious lesions suggestive of culprit parathyroid glands in patients with recurrent or persistent primary hyperparathyroidism (PHPT). STUDY DESIGN: Retrospective review. METHODS: Patients with recurrent or ...
Vasiliadis Ioannis - - 2013
We evaluated nuclear factor kappa B {NFkB, rs28362491 [-94ins/delATTG (W/D)]} and angiotensin converting enzyme {ACE; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO2) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating ...
Zhao C-T - - 2013
BACKGROUND: Psoriasis is associated with an increased risk of cardiovascular disease although the mechanism remains unclear. Recent studies have shown that such patients have a high prevalence of vitamin D (vit-D) deficiency and elevated parathyroid hormone (PTH) level. We hypothesized that vit-D deficiency and/or elevated PTH in psoriasis may contribute ...
Erfurth Eva Marie - - 2013
During the last 20 years a tremendous improvement in the care of patients with pituitary tumors and of hypopituitarism has been achieved. If we resolve most of the possible causes of the increased cardiovascular disease and stroke mortality a normal survival is expected in these patients. Recently, a large population based ...
Erkoç Mustafa Fatih - - 2013
Hearing loss (HL) is common in patients with chronic renal failure (CRF), but its cause is controversial. The aim of this study was to determine the effect of CRF on the bone density of the otic capsule using densitometric measurements with MDCT and to evaluate the relationship between changes in ...
Latus Joerg - - 2013
Background/Aims: Secondary hyperparathyroidism (sHPT) is known as a very common complication in patients with chronic kidney disease, and G-protein-coupled calcium-sensing receptor (CaSR), Vitamin D receptor (VDR) and Fibroblast growth factor receptor (FGFR)/Klotho complexes seem to be involved in its development. Methods: Hyperplastic parathyroid glands from 70 sHPT patients and normal ...
Yagasaki Hideaki - - 2013
Abstract Severe influenza infection may lead to neurological damage, such as encephalopathy. This may, in turn, cause acquired hypothalamopituitary dysfunction, which can result in severe morbidity and even death. We herein report two pediatric patients who developed influenza-associated hypopituitarism and were subsequently diagnosed with encephalopathy. They were diagnosed with acute ...
Bell David S H - - 2013
Recurrent hyperparathyroidism can occur following quadruple parathyroidectomy and during radical parathyroidectomy and so that future hypoparathyroidism is avoided autotransplantation of parathyroid tissue is often preformed. Herein, I describe a patient who was thought to have recurrent hyperparathyroidism following a quadruple parathyroidectomy based solely on a high intact parathyroid hormone level. ...
Wójcik Małgorzata M Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics, Polish-American Pediatric Institute, Jagiellonian University, Medical College, Cracow, Poland ; Department of Pediatric and Adolescent Endocrinology, Children's University Hospital in Cracow, Cracow, - - 2013
Patient: Female, 14 Final Diagnosis: Multiple pituitary hormone deficiency Symptoms: Hyponatremia Medication: - Clinical Procedure: Endovascular embolectomy Specialty: Endocrinology and Metabolic Objective: Patient complains/malpractice. Hyponatremia is one of the most common electrolyte disorders. Depending on the patient's hydration status, hyponatremia can be classified as hypovolemic, hypervolemic, or normovolemic. The last ...
Regi P - - 2012
INTRODUCTION: Mucinous cystic neoplasm (MCN) and solid pseudopapillary neoplasm (SPN) of the pancreas are uncommon hormone-related pancreatic tumours (HRPTs) with a clear predominance in young women. This trial aims to investigate the possible association between HRPTs development in males and phenotypic and sex hormone alterations. METHODS: We performed a retrospective ...
Gruson D - - 2012
OBJECTIVES: Parathyroid hormone (PTH) is a major systemic calcium-regulating hormone. Recent evidence has suggested that measurement of PTH might provide complementary information for the diagnosis and risk stratification of patients with heart failure (HF). The aim of our study was to compare intact and bioactive PTH assays in patients with ...
Nakai Kentaro - - 2013
The kidney chiefly maintains homeostasis of water, electrolytes, and other solutions. When kidney function is reduced, mineral metabolism is disrupted. Mineral and bone disorder in patients with chronic kidney disease associates with increased cardiovascular risk and mortality; however, management of chronic kidney disease-mineral and bone disorder in predialysis patients remains ...
Koc Zehra Pinar - - 2012
Objective: We retrospectively evaluated patients with end stage renal disease (ESRD) who were referred to our department for parathyroid scintigraphy. The aim of this study is to investigate the causes of the bone marrow uptake that we observed in the parathyroid scintigraphy.Methods: Eighteen patients (10 F, 8 M; 45-49, mean; ...
Monteleone Palmiero - - 2012
Background: Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ingestion. We hypothesized ...
Sprague Stuart M SM Division of Nephrology and Hypertension, NorthShore University HealthSystem, Evanston, IL 60201, USA. - - 2013
Parathyroid hormone (PTH) is a uremic toxin with multiple systemic effects including bone disorders (renal osteodystrophy), myopathy, neurologic abnormalities, anemia, pruritus, and cardiomyopathy. Hyperparathyroidism is common in CKD and results in significant morbidity and mortality if left untreated. Clinical practice guidelines from the Kidney Disease Improving Global Outcomes initiative broadened ...
Maffioli L - - 2012
Recently, in Italy, the reimbursement for the use of rhTSH in preparing patients for radiometabolic treatment of iodine-avid metastases from differentiated thyroid cancer has been made possible. Intramuscular administration of rhTSH increases the radioiodine uptake and thyroglobulin production by thyroid cells. In addition to the previous indications on the use ...
Su Pen-Hua - - 2012
We hypothesized that responses to growth hormone (GH) therapy by idiopathic short stature (ISS) and growth hormone deficiency (GHD) patients were associated with single nucleotide polymorphisms (SNPs) in the leptin (LEP) and leptin receptor (LEPR) genes. We retrospectively enrolled ISS (n=32) and GHD (n=38) patients and forty healthy age- and ...
Mohiyiddeen Lamiya - - 2012
OBJECTIVE: To assess the role of the variant p.Asn680Ser in the follicle-stimulating hormone receptor (FSHR) gene in determining ovarian response in patients undergoing in vitro fertilization (IVF) treatment. DESIGN: Prospective observational study. SETTING: Tertiary referral center for reproductive medicine. PATIENT(S): Women (n = 421) undergoing their first cycle of controlled ovarian ...
Ciro D'Orazio - - 2012
OBJECTIVE: Growth delay in cystic fibrosis is frequent and is usually the result of several interacting causes. It most often derives from severe respiratory impairment and severe malabsorption. There are however patients whose clinical condition is not severe enough to be held accountable for this phenomenon. We aimed at describing ...
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