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Huang Shih-Han S SH Department of Medicine, Division of Nephrology, Western University and London Health Sciences Centre, London, Canada; Department of Medical Biophysics, Western University, London, Canada; Department of Pediatrics, Western University, London, - - 2014
Dialysis patients have high mortality rate and the leading cause of death is cardiovascular disease. Uremic cardiomyopathy differs from that due to conventional atherosclerosis, where cardiovascular changes result in ineffective circulation and lead to tissue ischemia. Modern dialysis has significant limitations with fluid management probably the most challenging. Current evidence ...
Harrison Laura E A LE Department of Renal Medicine, Royal Derby Hospital, Derby, - - 2014
Background/Aims: Haemodialysis causes recurrent haemodynamic stress with subsequent ischaemic end-organ dysfunction. As dialysis prescriptions/schedules can be modified to lessen this circulatory stress, an easily applicable test to allow targeted interventions in vulnerable patients is urgently required. Methods: Intra-dialytic central venous oxygen saturation (ScvO2) and clinical markers (including ultrafiltration, blood pressure) ...
Chen Yan Y Department of Urology, Urodynamic Center, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China, - - 2014
To clarify the association between clinically defined simple stress urinary incontinence (SUI) symptoms and urodynamic SUI, we examined the relationship between Valsalva leak point pressure (VLPP) as measured by the Q-tip test and Stamey grade in simple female SUI. Two hundred grade I or II female SUI patients with SUI ...
Karlík Martin M 2nd Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, - - 2014
Backround Oxidative stress plays role in multiple sclerosis. Saliva can be potentially used to study the disease progression or treatment, because of its non-invasiveness and easy collection. But studies on saliva and multiple sclerosis are missing. The aim of this study was to compare the concentrations of salivary oxidative stress ...
Okada Ayako A Department of Cardiovascular Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, - - 2014
Atrial fibrillation (AF) is associated with oxidative stress and elevated brain natriuretic peptide (BNP) levels. However, the exact cardiac origin of oxidative stress and its association with BNP levels in AF patients remain unclear. Therefore, we investigated the chamber-specific plasma oxidative stress levels in patients with paroxysmal AF (PAF) and ...
Klawitter Jelena J University of Colorado Denver - - 2014
Cardiovascular disease (CVD) is the leading cause of premature mortality in ADPKD patients. The aim was to identify potential serum biomarkers associated with the severity of ADPKD. Serum samples from a homogenous group of 61 HALT A study ADPKD patients (early disease group with eGFR>60mL/min/1.73m(2)) were compared with samples from ...
Rivara Matthew B MB Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington; Kidney Research Institute, Seattle, Washington. Electronic address: - - 2014
Oxidative stress and systemic inflammation are highly prevalent in patients undergoing maintenance hemodialysis (MHD) and are linked to excess cardiovascular risk. This study examined whether short-term supplementation with pomegranate juice and extract is safe and well tolerated by MHD patients. The secondary aim was to assess the effect of pomegranate ...
Champion Sébastien S Centre Hospitalier Universitaire de La Réunion, Site Félix Guyon, Allée des Topazes, Réunion, France - - 2014
Stress cardiomyopathy (SC) is a transient ventricular dysfunction rarely described in the critical care setting. To evaluate the mechanisms, incidence, treatment and prognosis of SC. This is a retrospective observational study of every critically-ill patient admitted to the ICU over a period of two years. Among 1314 patients admitted in ...
Karabacak Mustafa M Department of Cardiology, Isparta State Hospital, Isparta, - - 2014
Objective: It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF). Subjects and Methods: The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis of asymptomatic HF (New York ...
Demir Mehmet M Department of Internal Medicine, Faculty of Medicine, Harran University, - - 2014
[Purpose] To evaluate the oxidative stress parameters and urinary deoxypyridinoline levels in geriatric patients with osteoporosis. [Subjects and Methods] Eighty geriatric patients aged over 65 years were recruited. Patients were divided into two groups: Group 1 (n=40) consisted of patients with osteoporosis, and Group 2 (n=40) consisted of patients without osteoporosis. ...
Mir Fozia F Tisch MS Research Center of New York, New York, - - 2014
To investigate the potential of 8-iso-prostaglandin F2α (8-iso-PGF2α) as a biomarker for disease activity and oxidative stress in the CSF of patients with multiple sclerosis (MS). The isoprostane 8-iso-PGF2α is an established biomarker for in vivo oxidative stress and lipid peroxidation. We measured CSF 8-isoPGF2α levels in 231 patients with ...
Vrndic Olgica B - - 2014
Ionizing radiation in differentiated thyroid cancer (DTC) patients treated with radioiodine (131-I) produces reactive oxygen species (ROS), which could induce oxidative stress with disturbance of redox balance. The aim of this study was to evaluate oxidative stress in DTC patients treated with 3.7 or 5.5 GBq of 131-I using values ...
Cortes Arthur Rodriguez Gonzalez AR Graduate Student, Department of Stomatology, University of São Paulo School of Dentistry, São Paulo, São Paulo, - - 2014
The influence of mechanical stimulation on the formation of torus mandibularis (TM) is still poorly understood. We sought to understand the etiology of TMs by investigating the role of parafunctional activity and mandibular morphology on the formation of TMs. We designed a case-control study for patients attending the dental clinic ...
Tortelli R R Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari, Bari, Italy; Department of Clinical Research in Neurology, Unit of Neurodegenerative Diseases, University of Bari, c/o Pia Fondazione Card. G. Panico, Tricase (Lecce), - - 2014
To evaluate whether cerebrospinal fluid (CSF) neurofilament light chain (NFL) levels could predict the time to generalization (TTG) in amyotrophic lateral sclerosis (ALS). Cerebrospinal fluid NFL levels of 37 cases of sporadic ALS were measured and the time of symptom spreading from spinal or bulbar localization to both (TTG) was ...
Kastritis E E Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, - - 2014
Suppression of uninvolved immunoglobulins is common in multiple myeloma (MM) but the prognostic significance of this phenomenon has not been assessed. We evaluated the prognostic significance of the preservation of uninvolved immunoglobulins in 1755 consecutive, unselected, patients with newly diagnosed, symptomatic MM with pre-therapy immunoglobulin levels measured by nephelometry. Suppression ...
Wang Chen C Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, - - 2014
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare plasma cell dyscrasia. Nearly all patients present with a λ-restricted monoclonal gammopathy. Most patients with POEMS syndrome have been reported to have a normal serum free light chain ratio (sFLC-R), but the underlying mechanism is still unclear. ...
Shanks Anne-Marie AM Core Medical Trainee, NHS Grampian, Aberdeen, Aberdeenshire, - - 2014
We present details of a man who was originally diagnosed with sarcoidosis, based on a combination of nodal granulomatous inflammation and radiology confirming bilateral hilar lymphadenopathy with pulmonary infiltrates. The patient subsequently developed splenomegaly and idiopathic thrombocytopenic purpura (ITP) and, latterly, a severe cavitating pneumonia. Serum immunoglobulins were checked, confirming ...
Yamagami Keiko K Department of Internal Medicine, Osaka City General Hospital, - - 2014
A 24-year-old man presented with fever and pleural effusion predominantly containing lymphocytes. Cultures of the pleural effusion and blood revealed Campylobacter fetus, and laboratory studies showed a low serum level of immunoglobulin. The patient was diagnosed with C. fetus pleuritis, bacteremia and primary hypogammaglobulinemia, and subsequent treatment with meropenem and ...
Döhring Juliane J Department of Neurology, Memory Disorders and Plasticity Group, University Hospital Schleswig-Holstein, University of Kiel Kiel, - - 2014
The transient global amnesia (TGA) is a rare amnesic syndrome that is characterized by an acute onset episode of an anterograde and retrograde amnesia. Its origin is still debated, but there is evidence for psychological factors involved in TGA. In neuroimaging, selective lesions in the CA1 field of the hippocampus ...
Victor Victor M VM Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Valencia, Spain; Service of Endocrinology, University Hospital Doctor Peset, Valencia, Spain; Institute of Health Research INCLIVA, University of Valencia, Valencia, - - 2014
Anorexia nervosa is a common illness among adolescents and is characterised by oxidative stress. The effects of anorexia on mitochondrial function and redox state in leukocytes from anorexic subjects were evaluated. A multi-centre, cross-sectional case-control study was performed. Our study population consisted of 20 anorexic patients and 20 age-matched controls, ...
Tanuma Naoyuki N Department of Pediatrics, Tokyo Metropolitan Fuchu Medical Center for the Disabled, 2-9-2 Musashidai, Fuchu, Tokyo 183-8553, Japan ; Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, - - 2014
To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-6 encephalopathy) ...
Pendón-Ruiz de Mier M Victoria - - 2013
Acute kidney failure in multiple myeloma (MM) occurs in 12%-20% of patients and is a poor prognostic factor for patient survival. Recent studies have shown that dialysis with a High-Cut-Off membrane (HCO) removes free light chains (FLC) effectively although with significant albumin loss. Other adsorption-based techniques, such as haemodiafiltration with ...
Feravich Susan M SM Duke Epilepsy Center, Duke University Hospital, Durham, North Carolina, USA. - - 2013
Evaluation of seizure activity may require the addition of T1/T2 or a subtemporal chain of electrodes based on the 10-10 measurement system. Placement of additional electrodes helps to localize seizure activity in pre-surgical patients and to reveal areas of abnormality which cannot be easily discerned with International 10-20 System of ...
Jardin Fabrice - - 2013
Abstract Elevated serum free light chains (FLC) have been associated with unfavorable prognostic in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to determine the clinical relevance of a quantitative assessment of intact circulating immunoglobulin (Ig), using serum Ig heavy chain/light chain pair (HLC) measurements in DLBCL ...
Gottenberg Jacques-Eric - - 2013
To analyze the clinical and immunological characteristics at enrollment in a large prospective cohort of patients with primary Sjögren's syndrome (pSS) and to investigate the association between serum BAFF, beta2-microglobulin and free light chains of immunoglobulins and systemic disease activity at enrollment. Three hundred and ninety five patients with pSS ...
Girón José A JA Florida State University College of Medicine, Tallahassee, FL 32306, USA ; University of Central Florida College of Medicine, Orlando, FL 32816, USA ; Department of Medicine, Orlando Regional Medical Center, Orlando, FL 32806, - - 2013
Objective. Helicobacter pylori provokes a host of immune alterations upon colonizing the gastric mucosa. Design. We report 22 individuals with confirmed Helicobacter pylori infection who were also managed for the concurrent elevation of immunoglobulin free light chain (kappa and lambda) levels. Result. Of the 22 patients, 15 patients (68.2%) had ...
Kastritis E - - 2012
Asymptomatic multiple myeloma (AMM) is characterized by a constant risk of progression to symptomatic myeloma. To evaluate previously recognized risk factors and to identify high-risk features we analyzed 96 patients with AMM and at least 18 months of follow-up. The progression rate at 1,2, and 3 years was 8%, 15% ...
Tamayo Eduardo - - 2012
PURPOSE: There is increasing evidence on the relationship between endogenously produced immunoglobulins and the clinical outcome in septic shock (SS). MATERIALS AND METHODS: Levels of immunoglobulin G (IgG) subclasses, immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin E were measured in plasma from 42 patients with SS and in 36 ...
Wolff Fleur - - 2012
OBJECTIVES: Preliminary results of the IgA Hevylite™ assay including the establishment of the 95% reference interval and assessment of the specificity and sensitivity in different populations, are reported. DESIGN AND METHODS: The concentrations of IgA heavy and light chains (HLC) enabling to determine an IgAκ /IgAλ ratio were quantified in ...
Dogaru Monica - - 2012
The purpose of this study was to determine the correlations between the concentration of free light chains (kappa, lambda and ratio kappa/lambda) and two other markers, M- protein and pathological total intact immunoglobulin in four groups of patients with intact immunoglobulin multiple myeloma (IIMM) at the diagnosis and during the ...
Dhaliwal Harpreet K HK Clinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United - - 2012
Azathioprine (AZA) is used to maintain remission in autoimmune hepatitis (AIH), but up to 18% of patients are unresponsive. AZA is a prodrug, and the formation of active thioguanine nucleotide (TGN) metabolites varies widely. We aimed to assess the relationship between AZA metabolite concentrations (i.e., TGNs and methylmercaptopurine nucleotides [MeMPNs]), ...
Li Xin - - 2012
Background/Aims: Adiponectin can initiate a broad range of metabolic and immunological effects. Little is known about the role of adiponectin in hepatitis Brelated liver disease and metabolic syndrome (MS). Methodology: We studied 138 patients with untreated chronic hepatitis B (CHB), who were from Beijing Ditan hospital in 2005 to 2009. ...
McQuarrie Emily P EP BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK. - - 2012
Blockade of the MR (mineralocorticoid receptor) in CKD (chronic kidney disease) reduces LVMI [LV (left ventricular) mass index] and proteinuria. The MR can be activated by aldosterone, cortisol and DOC (deoxycorticosterone). The aim of the present study was to explore the influence of mineralocorticoids on LVMI and proteinuria in patients ...
Součková L - - 2012
PURPOSE: Bioavailability of clopidogrel in the form of crushed tablets administered via nasogastric tube (NGT) has not been established in patients after cardiopulmonary resuscitation. Therefore, we performed a study comparing pharmacokinetic and pharmacodynamic response to high loading dose of clopidogrel in critically ill patients after cardiopulmonary resuscitation (CPR) with patients ...
Dennis Mike - - 2012
Barasertib (AZD1152) is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML). The pharmacokinetic (PK), metabolic and excretion profiles of barasertib and barasertib-hQPA were characterized in ...
Girardin F - - 2012
Summary.  Liver kidney microsomal type 1 (LKM-1) antibodies have been shown to decrease the CYP2D6 activity in vitro and are present in a minority of patients with chronic hepatitis C infection. We investigated whether LKM-1 antibodies might reduce the CYP2D6 activity in vivo. All patients enrolled in the Swiss Hepatitis ...
Chariatte Vincent - - 2012
IntroductionHypospadias is associated with anomalies of the urinary tract, but the exact prevalence and significance of these anomalies are still controversial.ObjectivesTo assess the percentage of patients with hypospadias and associated urological anomalies, either requiring or not requiring medical or surgical attention.Material and methodsWe searched several databases using the following Mesh ...
Olischar Monika - - 2012
Background: The utility of amplitude-integrated electroencephalography (aEEG) monitoring has been established for patients with neonatal hypoxic-ischemic encephalopathy. Objective: To evaluate the role of aEEG in the diagnostic process and treatment of patients with encephalopathy due to inborn errors of metabolism. Methods: Cases collected through an international registry were divided into ...
Shilpashree H S - - 2012
The aim of the present study was to analyze the influence of smoking on the salivary immunoglobulin response in smokers and to evaluate the salivary immunoglobulin A in patients with recurrent aphthous ulcers. The study included total of 80 subjects, of whom 40 were having history of chronic smoking habit, ...
Lai Yongqing - - 2012
Introduction: The use of ketamine as a recreational drug is on the increase among young adults attending clubs and parties. Recreational ketamine users have anecdotally reported increased lower urinary tract symptoms while using the substance. Methods: We describe the severe lower urinary tract symptoms experienced in 6 patients with chronic ...
van Hulsteijn Leonie T - - 2012
Background: Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). ?Aim: To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL patients.?Methods: In 114 consecutive ...
Shen Luming - - 2012
PURPOSE: To compare renal function and metabolic abnormalities of cystine stone patients and calcium oxalate stone patients in China. METHODS: Between 2008 and 2011, thirty cystine stone patients were involved in our study, and an equal number of age- and gender pair-matched patients with calcium oxalate stones. Non-stone forming individuals ...
Dewitte Antoine - - 2012
Acute kidney injury (AKI) is a dynamic process that evolves from an early reversible condition to an established disease. Value of urine indices in the event of AKI is uncertain in critically ill patients. The aim of this study was to evaluate the performance of fractional excretion of urea (FeU) ...
Cangemi G - - 2012
Therapeutic drug monitoring (TDM) of major metabolites of thiopurine drugs is a widely used tool for assessing treatment efficacy and toxicity in patients with inflammatory bowel disease (IBD). We report the laboratory and clinical validation of a simple and reliable high performance liquid chromatography (HPLC) method for the measurement of ...
van Doormaal J J - - 2012
Risk indicators of indolent systemic mastocytosis (ISM) in adults with clinical suspicion of ISM without accompanying skin lesions [urticaria pigmentosa (UP)] are lacking. This study aimed at creating a decision tree using clinical characteristics, serum tryptase, and the urinary histamine metabolites methylimidazole acetic acid (MIMA) and methylhistamine (MH) to select ...
Mourand Isabelle - - 2012
PURPOSE: Hypothermia is a promising neuroprotective therapy. We studied the feasibility and safety of very prolonged moderate hypothermia for severe acute ischemic stroke. METHODS: Moderate hypothermia was induced within 24h after a severe ischemic stroke involving the middle cerebral artery. Hypothermia, with cooling blankets, reduced body-core temperature to 32-33°C, and ...
Ouyang Dong - - 2012
Background/Aims: 1H-NMR is a powerful approach of metabolomics. This study aimed to apply it to the profiling of serum metabolites in patients with pancreatitis, and to analyze the characteristic metabolites of pancreatitis. Methodology: Serum samples were taken from 17 pancreatitis patients and 23 healthy subjects and subjected to 1H-NMR and ...
Nayan Madhur - - 2012
The current Canadian Urological Association (CUA) guideline recommends two 24-hour urine collections in the metabolic evaluation for patients with urolithiasis. The aim of the present study was to compare two consecutive 24-hour urine collections in patients with a history of urolithiasis presenting to a tertiary stone clinic. We retrospectively reviewed ...
Dunn Warwick B - - 2012
BACKGROUND: Prolonged peritoneal dialysis (PD) therapy can result in the development of encapsulating peritoneal sclerosis (EPS), characterized by extensive sclerosis of the peritoneum with bowel adhesions often causing obstruction.METHODS: As a proof-of-principle study, holistic profiling of endogenous metabolites has been applied in a prospective collection of PD effluent collected in ...
Aoki Teruaki - - 2012
BACKGROUND: We conducted a survey regarding irregular bowel movement in gastrectomized patients. Their defecation frequency, intestinal microflora, and intestinal environment were studied and compared with those of healthy controls. METHODS: As a first step, a questionnaire survey on bowel movement, involving 769 patients and 312 healthy controls (total: 1,081 subjects), ...
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