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Fonseca Felipe Paiva FP Department of Oral Diagnosis, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, - - 2014
The purpose of this study was to evaluate the presence of myofibroblasts, frequently associated with a more aggressive neoplastic behavior, in oral tongue squamous cell carcinoma (TSCC) of young patients and to compare with the distribution observed in older patients. Tumor samples from 29 patients younger than 40 years old ...
Ghozlan Manal F MF Clinical Pathology, Ain Shams University, Cairo, - - 2014
Deep venous thrombosis (DVT) is based upon clinical suspicion in patients at risk and confirmatory duplex imaging of the deep venous system of the affected extremity. The aim of the present study was to determine different cutoff points of D-dimer, P-selectin and microparticles that could be used in early diagnosis ...
Medić-Stojanoska Milica - - 2014
Currently there is little information on the effects of prolactin (PRL) on the coagulation and fibrinolytic systems. The aim of this study was to evaluate the effects of hypeprolactinemia on the parameters of the hemostatic system and activation of the coagulation system. We studied PRL levels, body mass index (BMI), ...
Kleinjan Ankie - - 2014
Although well-established for suspected lower limb deep venous thrombosis, an algorithm combining a clinical decision score, d-dimer testing, and ultrasonography has not been evaluated for suspected upper extremity deep venous thrombosis (UEDVT). To assess the safety and feasibility of a new diagnostic algorithm in patients with clinically suspected UEDVT. Diagnostic ...
Okazaki Toshiyuki T Department of Neurosurgery, Tokushima Prefectural Miyoshi Hospital, Japan. Electronic address: - - 2014
Previous studies reported that the plasma d-dimer level reflects the activity of thrombus formation in the left atrium of patients with acute cerebral infarction and acute aortic dissection (AAD). Brain natriuretic peptide (BNP) is considered to be a marker of chronic heart failure. The differential diagnosis in the emergency room ...
Nastasijević Borovac Desa D Clinic for Lung Diseases, Clinical Center Niš, Knez Selo¹, School of Medicine, University of Niš, Niš²; - - 2014
Aim To determine whether D-dimer in patients with communityacquired pneumonia (CAP) can predict mortality risk better than standard biomarkers. Methods White blood cell (WBC), C-reactive protein (CRP) and D-dimer in 129 patients with CAP were analyzed. The recommended Pneumonia Severity Index (PSI) score was used to classify CAP patients into ...
Nata Shinichi S Department of Surgery, Kurume University School of - - 2014
Objective: The present study aimed to establish whether a more optimal cutoff value for D-dimer testing could definitively rule out acute deep vein thrombosis (DVT). Methods: Between April 2009 and March 2010, 190 referral patients suspected to have DVT were assessed by the D-dimer assay. Additionally, ultrasonography (US) and computed ...
Cini M M Department of Angiology and Blood Coagulation 'Marino Golinelli', University Hospital S. Orsola-Malpighi, Bologna, - - 2014
The use of adapted cut-off values in the elderly, combined with clinical probability (PTP), increases the proportion of patients in whom venous thromboembolism (VTE) can be safely excluded, compared with the conventional cut-off value of 500 μg/L fibrinogen equivalent units (FEU). We evaluated the clinical performance of three different approaches to ...
Mirshahi Shahsoltan S Service d'Onco-Hématologie, Hôtel-Dieu, Paris, France; Université Paris Diderot Paris-7, UMR INSERM U965, Paris, - - 2014
To establish a new and reliable assay for quantification of the soluble fibrin (SF) in combination with that of D-dimer for early diagnosis of venous thromboembolism. The SF assay is based on D-dimer generated after incubation of plasma with tissue-type plasminogen activator (t-PA). SF and standard D-dimer assays, run in ...
Babak Sam S Department of Respiratory Medicine, Gold Coast University Hospital, Gold Coast, Queensland, - - 2014
We report the case of a middle-aged man where a diagnosis of pulmonary embolism (PE) was delayed due to initial underestimation of risk and over-reliance on D-dimer testing. The patient presented with pleuritic chest pain after a 5 h domestic flight. The treating clinicians presumed that this duration of immobilisation was ...
Lindner Gregor G Department of Emergency Medicine, Inselspital, University Hospital Bern, Switzerland; Department of Internal Medicine, Inselspital, University Hospital Bern, Switzerland. Electronic address: - - 2013
D-Dimer levels are often elevated in renal insufficiency. The diagnostic accuracy of D-Dimer to rule out pulmonary embolism in patients with renal insufficiency is unclear. We evaluated the data of patients presenting to our emergency department and receiving computed tomography angiography (CTA) to rule out pulmonary embolism with measurement of ...
Wang X - - 2013
We aimed to explore the model for end-stage liver disease (MELD), Child-Turcotte-Pugh (CTP) score, endotoxin, bleeding score and dynamic changes of D-dimer in chronic liver failure patients with portal hypertension and esophageal varices, and explored their potential contact with bleeding in short-term prognosis. Chronic liver failure patients with esophageal varices ...
van der Hulle Tom - - 2013
Computed tomography pulmonary angiography (CTPA) is frequently requested using diagnostic algorithms for suspected pulmonary embolism (PE). For suspected deep vein thrombosis it was recently shown that doubling the D-dimer threshold in patients with low pre-test probability safely decreased the number of ultrasonographies. We evaluated the safety and efficiency of a ...
Akpinar Evrim Eylem - - 2013
The aim of this study was to evaluate the D-dimer levels in patients with chronic obstructive pulmonary disease (COPD) exacerbation with and without pulmonary embolism (PE) and to attempt to define a new cut-off value for D-dimer to exclude the diagnosis of PE in patients with COPD exacerbation. This cross-sectional ...
Stein Paul D - - 2013
We assessed the prevalence of elevated quantitative latex agglutination assay for <sc>d</sc>-dimer in patients in the emergency department in whom pulmonary embolism (PE) was excluded. <sc>d</sc>-dimer was normal (<230 ng/mL) in 435 (83%) of the 522 patients. <sc>d</sc>-dimer was normal in 88% of the patients with musculoskeletal or related chest ...
Nguyen Geoffrey C - - 2013
BACKGROUND:: Asymptomatic deep vein thrombosis (DVT) occurs in up to 11% of medical inpatients. The incidence of asymptomatic DVT among patients with inflammatory bowel disease (IBD) is unknown but may be even higher. D-dimer is effective for DVT screening, but its utility has not been studied in the IBD population. ...
Hiltunen Sini - - 2013
OBJECTIVES: Cerebral venous thrombosis (CVT) is a disease with varying clinical presentation and diagnosis presents many challenges in clinical practice. We investigated, whether D-dimer levels reflect clinical presentation, radiologic features, and outcome in CVT. METHODS: We included all consecutive patients with CVT treated in our hospital from 1987 to 2010 ...
Haas Fred J L M - - 2012
The exclusion of deep venous thrombosis (DVT) in the elderly is hampered by low specificity in clinical decision of D-dimer assays in older patients. To reduce false-positive results, we evaluated specific fibrin(ogen) degradation product assays for their contribution in the diagnosis of DVT. In a post-hoc study with outpatients suspected ...
Hajsadeghi Shokoufeh - - 2012
Pulmonary thromboembolism (PTE) may increase D-dimer and decrease fibrinogen levels. However, in settings such as intensive care units (ICU) and in long-term hospitalised patients, several factors may influence D-dimer and fibrinogen concentrations and make them unreliable indicators for the diagnosis of PTE. The aim of this study was to evaluate ...
Struglics André - - 2012
OBJECTIVE: To understand aggrecan degradation in juvenile idiopathic arthritis (JIA), the pattern and abundance of aggrecan fragments in synovial fluid aspirates from JIA patients were analysed and compared with aggrecan fragments in synovial fluids from patients with other arthritides, juvenile knee injury and a knee-healthy reference group. METHODS: The concentration ...
Tsa Ping-Huang - - 2012
Quantitative electroencephalographs (qEEG) provide a potential method to objectively quantify the cortical activations in Alzheimer's disease (AD), but they are too insensitive to probe the alteration of EEG in the early AD. The sample entropy (SaEn) attempts to quantify the complex information embedded in EEG non-linearly, which fits in that ...
Idorn L - - 2012
After the Fontan procedure, patients face an increased risk for thromboembolic events (TE). The etiology for this increased thrombogenecity is incompletely understood. This study aimed to determine the prevalence of TE in Danish Fontan patients and to bring new insights into the etiology of TE. Using a population-based design, we ...
Hagiwara Akiyoshi - - 2012
This study evaluated whether degradation products of plasma fibrin and fibrinogen (FDP) level can be used to differentiate acute aortic dissection (AAD) from acute myocardial infarction (AMI), angina pectoris, acute cerebral infarction, or transient cerebral ischemic attack (TIA). Ninety-six consecutive patients with definitive diagnosis of AAD by contrast-enhanced computed tomography ...
Takahashi Ryoichi - - 2012
Objective: Familial amyloid polyneuropathy (FAP) is an autosomal dominant form of hereditary amyloidosis. Several studies reported coagulation factor X deficiency and excessive fibrinolysis in immunoglobulin light chain amyloidosis. However, few have investigated coagulation and fibrinolysis in FAP. The objective of this study was to determine abnormalities in plasma biomarkers of ...
Sharma Girish G Department of Pediatrics, Rush University Medical Center, Chicago Illinois, - - 2013
The enzyme Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) removes 4-sulfate groups from chondroitin-4-sulfate and dermatan sulfate and is required for the degradation of these sulfated glycosaminoglycans (sGAGs). Since these GAGs accumulate in patients with Cystic Fibrosis (CF), we investigated the activity of ARSB in leukocytes of patients with CF, to consider if ...
Rourke C - - 2012
Background: Low fibrinogen levels are known to occur in trauma. However, the extent of fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and association with patient outcomes remain unclear. Objectives: The study aims were to characterize admission fibrinogen level and correlate it to factors associated with injury; describe ...
Dentali F F Department of Clinical Medicine, Insubria University, Varese, Italy. - - 2012
Quantitative measurement of circulating D-dimer, a product of fibrin degradation, has been shown to be a very useful diagnostic tool in the management of patients with suspected deep vein thrombosis and/or pulmonary embolism. Whether D-dimer can play a similar role in the diagnostic approach to patients with suspected cerebral vein ...
Taskapan Hulya - - 2012
Deficiency of 1,25-dihydroxyvitamin D [1,25(OH)(2)D] and excessive fibroblast growth factor (FGF23) are suggested to be associated with increased mortality in patients with chronic kidney disease (CKD). Generally, 24-hydroxylation has been considered the first step in the degradation pathway of 1,25(OH)(2)D and 25(OH)D. 24,25-dihydroxyvitamin D [24,25(OH)(2)D] was believed to be a ...
Veidal S S - - 2012
OBJECTIVES: Type V collagen has been demonstrated to rate limit fibril formation. The aim of this study was to develop an ELISA capable of detecting a fragment of type V collagen generated by MMP-2/9 and to evaluate the assay as biomarker for ankylosing spondylitis (AS). DESIGN AND METHODS: A fragment ...
Leffler Jonatan - - 2012
Ongoing inflammation including activation of the complement system is a hallmark of systemic lupus erythematosus (SLE). Antimicrobial neutrophil extracellular traps (NETs) are composed of secreted chromatin that may act as a source of autoantigens typical for SLE. In this study, we investigated how complement interacts with NETs and how NET ...
Kalai Eya - - 2012
OBJECTIVES: Proteolytic degradation of aggrecan is a hallmark of the pathology of osteoarthritis. The aim of this study was to develop enzyme-linked immunosorbent assay (ELISA) to quantify the serum levels of specific aggrecan fragments generated by aggrecanases-mediated cleavage. We investigated the relationships between these two aggrecan degradations fragments and urinary ...
Huang Jeffrey T J - - 2012
Although an increased concentration of degraded elastin products in patients with chronic obstructive pulmonary disease (COPD) has been reported for many years, its clinical validity and utility remain uncertain due to technical difficulties, small study groups and the unknown relationship between exacerbation and elastin degradation. The objectives of this study ...
Sukati Suriyan - - 2012
Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the activity of calpain protease. The aim of this study was to correlate the activity of calpain and its ...
Meng Wei - - 2012
Neutrophil extracellular traps (NET) consist of a DNA scaffold that can be destroyed by Deoxyribonuclease (DNase). Thus DNases are potential prerequisites for natural counter regulation of NETs formation. In the present study, we determined the relationship of NETs and DNase after major trauma. Thirty-nine major trauma patients, 14 with and ...
Saray Aida A Department of Gastroenetrology and Hepatology, Clinical Center of Sarajevo Universitiy, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina. - - 2012
The aim of the study was to investigate plasma D-dimer concentration in patients with liver cirrhosis with and without ascites and to evaluate the impact of ascites depletion on circulating plasma D-dimer levels. Sixty patients with liver cirrhosis were recruited and categorized into two groups: cirrhotic patients without ascites in ...
Ubhi Baljit K BK Dept of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, - - 2012
There is a paucity of biomarkers for chronic obstructive pulmonary disease (COPD). Metabolomics were applied to a defined COPD patient cohort from the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points). Results were correlated with accepted biomarkers for the disease. Baseline control serum (n=66) and Global Initiative ...
Bay-Jensen Anne C - - 2011
Ankylosing spondylitis (AS) is characterized by gradual cementation of the vertebrae, a process that is described by excessive extracellular matrix remodeling. Specific matrix metalloproteinase (MMP)-derived collagen fragments are released to the circulation, and measurement of those might act as biomarkers of ankylosis. The aim of the study was to investigate ...
Lai Kar Neng - - 2012
Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy, concerns remain regarding the bioincompatible nature of standard PD fluid (PDF). Short-term studies of new biocompatible PDFs low in glucose degradation products (GDPs) reveal divergent results with respect to peritoneal integrity. We studied 125 patients on maintenance ...
Shen Yu-Min - - 2011
Hypodysfibrinogenemia is characterized by both a qualitative and quantitative deficiency of fibrinogen. Here we report a patient with remote history of bleeding and presents with provoked deep venous thrombosis associated with hypodysfibrinogenemia. Molecular studies identified the presence of fibrinogen Epsom, which was previously reported in a family with pregnancy associated ...
Findikoglu G - - 2011
Study design:Clinical cross-sectional study.Objectives:To investigate the cartilage degradation by turnover of C-telopeptide fragments of collagen type-II (CTX-II), a molecule specific for articular cartilage in spinal cord injured patients with respect to clinical functional status.Setting:Physical Medicine and Rehabilitation Clinics, hospital settings.Methods:In 68 patients with spinal cord injury (SCI) level and severity ...
Cui Guanyu - - 2011
BACKGROUND: Lumbar spinal canal stenosis (LSCS) is one of the most common spinal disorders in the elderly, and ligamentum flavum (LF) hypertrophy is an important cause of LSCS. Matrix metalloproteinase 13 (MMP13) can degrade fibrillar collagens and elastic microfibrils, and is involved in inflammation and fibrosis. The purpose of this ...
Masiero Paulo Ricardo - - 2011
The deterioration of the ventilation-to-perfusion distribution in patients with chronic obstructive pulmonary disease (COPD) reflects structural changes affecting both the airways and the blood vessels. These changes result in lung perfusion abnormalities that may be quantified by lung perfusion single photon emission computed tomography (SPECT). To compare the perfused lung ...
Damasceno Renato W - - 2011
Purpose: To determine the elastic fiber content and ultrastructure as well as the expression of elastin-degrading enzymes in biopsy specimens from patients with involutional ectropion and entropion. Materials and Methods: Twenty consecutive patients with involutional ectropion (group 1) and twenty consecutive patients with entropion (group 2) were matched with twenty control patients ...
Stone Andrew C - - 2011
Pulmonary hypertension (PH) is associated with decreased overall survival in patients with chronic lung disease. The purpose of this study was to determine the effect of echocardiographic evidence of PH on 1-year survival in patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (COPD). This is a retrospective study ...
Altiay G - - 2012
The aim of this study was to assess the role of labelled leukocyte scintigraphy in the diagnosis and monitorization of response to therapy of patients with active bronchiectasis. Twenty patients underwent (99m)Technetium hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) labelled white blood cell (WBC) scintigraphy. A second scintigraphy was performed in 13 patients at ...
Martínez-García Miguel Ángel - - 2011
ABSTRACT BACKGROUND: Previous studies have shown a high prevalence of bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease (COPD). However, the factors associated with bronchiectasis remain unknown in these patients. The objective of this study is to identify the factors associated with bronchiectasis in patients with moderate-severe COPD. METHODS: ...
Jenkins Peter - - 2011
PURPOSE: To systematically assess the spectrum of radiologic changes in the lung after radiation therapy for non-small-cell lung cancer. METHODS AND MATERIALS: We reviewed the cases of 146 patients treated with radical radiotherapy at our institution. All patients had computed tomography (CT) scans performed 3 months after completion of therapy. ...
Montani David - - 2011
Neurofibromatosis type I (NF1) is a rare genetic disease caused by mutations in the NF1 gene, which codes for tumor suppressor neurofibromin. NF1 is transmitted as an autosomal dominant and fully penetrant trait with no sex predominance. Precapillary pulmonary hypertension (PH) is a severe complication of NF1, initially described in ...
Klarod Kultida - - 2011
OBJECTIVE: Malnutrition frequently occurs in lung cancer patients. We aimed to determine nutritional status and antioxidant and mineral levels in Thai patients with lung cancer. METHODS: A prospective study with matched case-control was conducted. Nutritional status was assessed by body mass index (BMI) and subjective global assessment (SGA). Eastern Cooperative ...
Kondo Ryoichi - - 2011
Objectives: We estimated the influence of chronic obstructive pulmonary disease (COPD) upon the clinicopathological characteristics of lung cancer (LC) in Japanese surgical cases by comparing LC cases in non-COPD smokers. Method: A consecutive cohort comprising 157 COPD patients (78 in Global Initiative for Obstructive Lung Disease-1 (GOLD-1) and 79 in ...
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