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le Jeune Sarah S Department of Surgical and Radiological Sciences, University of California, 1 Shields Avenue, Davis, CA 95616, USA. Electronic address: - - 2014
Abdominal ultrasound is an invaluable aid in the evaluation of the colic patient but can be heavily influenced by patient preparation, individual horse-to-horse variation, availability of ultrasound transducers, technique, experience level of the examiner, and complexity of the abdominal disorder. This article describes ultrasonographic anatomy of the normal equine abdomen ...
Van Gossum Andre A Department of Gastroenterology, Erasme Hospital, Université Libre de Bruxelles, Brussels, - - 2014
Video capsule endoscopy, which was initially developed for exploring the small bowel, has been adapted for investigating the colon. This review summarizes recent developments in colon capsule technology as well as indications for its use. Second-generation PillCam colon capsule endoscopy (CCE-2) has been recently developed and has significantly improved the ...
Lee Hyun Jung HJ Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, - - 2014
The serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) have recently been shown to be correlated highly with disease activity in patients with intestinal Behçet's disease (BD). However, it remains unclear whether sTREM-1 levels reflect endoscopic activity in intestinal BD. This study aimed to evaluate the correlation ...
Pucciani F F Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy, - - 2014
The motility of the defunctionalized colon, distal to transverse loop colostomy, has never been studied "in vivo." The aim of our study was to evaluate the influence of transverse loop colostomy on colonic motility. Thirteen patients were examined before stoma closure by means of clinical evaluation and colonic manometry; we ...
Fujisawa Daisuke D Allergy and Immunology Group, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan; Department of Dermatology, Nihon University School of Medicine, Tokyo, - - 2014
Wheal reactions to intradermally injected neuropeptides, such as substance P (SP) and vasoactive intestinal peptide, are significantly larger and longer lasting in patients with chronic urticaria (CU) than in nonatopic control (NC) subjects. Mas-related gene X2 (MrgX2) has been identified as a receptor for basic neuropeptides, such as SP and ...
Mujagic Z Z Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center+, Maastricht, The - - 2014
Intestinal permeability has been studied in small groups of IBS patients with contrasting findings. To assess intestinal permeability at different sites of the GI tract in different subtypes of well-characterised IBS patients and healthy controls (HC), and to assess potential confounding factors. IBS patients and HC underwent a multi-sugar test ...
Kara Nursu N Department of Pediatrics, Sisli Etfal Training and Research Hospital, Istanbul, - - 2014
The aim of the study was to determine the topographic prevalence of lymphoid follicles, lymphoid aggregates, gastric glandular atrophy and intestinal metaplasia among children with chronic abdominal pain. The association between these lesions and age, type of gastritis and Helicobacter pylori density was also assessed. A total of 358 patients ...
Trebicka Jonel J Department of Internal Medicine I, University of Bonn, Germany; Gastrounit, Medical Division, Hvidovre Hospital, University of Copenhagen, - - 2014
Patients with liver cirrhosis display hypocontractility of splanchnic vessels due to dysregulation of vasoactive proteins, such as decreased effect of RhoA/ROCK and increased activity of β-Arrestin-2 and eNOS. However, it is unknown whether the dysregulation of vasoactive proteins is displayed in other vessels. We investigated whether expression of vasoactive proteins ...
Marie I I Department of Internal Medicine, Rouen University Hospital, Rouen, - - 2014
To date, there are no large studies on videocapsule endoscopy in systemic sclerosis (SSc). Consequently, the prevalence and features of gastrointestinal mucosal abnormalities in SSc have not been determined. To determine both prevalence and characteristics of gastrointestinal mucosal abnormalities in unselected patients with SSc, using videocapsule endoscopy. To predict which ...
Covington J J School of Engineering, University of Warwick, Coventry, - - 2014
Coeliac disease (CD), a T-cell-mediated gluten sensitive enteropathy, affects ~1% of the UK population, and in adults presents with a wide range of clinical features; often mistaken for irritable bowel syndrome (IBS). Heightened clinical awareness and serological screening identifies those likely to have CD; the diagnosis confirmed by histological features ...
Caccaro Roberta R Department of Surgical Oncological and Gastroenterological Sciences, University of Padua, via Giustiniani 2, 35128, Padua, Italy, - - 2014
Non-invasive markers able to identify patients with chronic diarrhea at risk of organic disease are missing. Aim of the study was to assess the diagnostic ability of intestinal permeability (IP) test and fecal lactoferrin (FL) in distinguishing functional from organic disease in patients with chronic diarrhea. We retrospectively enrolled patients referring ...
Larsson Geir G Geir Larsson, Department of Medicine, Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, NO-0440 Oslo, - - 2014
To investigate whether routinely measured clinical variables could aid in differentiating intestinal tuberculosis (ITB) from Crohn's disease (CD). ITB and CD patients were prospectively included at four South Indian medical centres from October 2009 to July 2012. Routine investigations included case history, physical examination, blood biochemistry, ileocolonoscopy and histopathological examination ...
Odgren Mike - - 2014
Upper gastrointestinal examinations are common procedures in many radiology departments. Performing this examination on pediatric patients requires understanding the formation of the gastrointestinal tract and the various disease processes and anatomical variances that can occur. The examination also requires a thorough patient history. This article discusses embryologic development and anatomy ...
Patil Anant D AD Freelance Consultant, Medical Communication and Training, - - 2014
Altered gastrointestinal (GI) motility is seen in many pathological conditions. Reduced motility is one of the risk factors for development of a small intestinal bacterial overgrowth (SIBO). Hypothyroidism is associated with altered GI motility. The aim of this article was to study the link between hypothyroidism, altered GI motility and ...
Kaur Jaspreet J *Department of Super Specialty of Gastroenterology †General Surgery, Postgraduate Institute of Medical Education & Research ‡Biophysics, Panjab University, Chandigarh, - - 2014
Gallstones (GS) are associated with slow intestinal transit but the effect of altered transit time on physiological changes in gastrointestinal tract among GS patients is poorly understood. To investigate the association of gallstone disease with change in intestinal motility and how motility alters serum bile acid (SBA) levels. A total ...
Cernuda-Morollón Eva E Neuroscience Area, Service of Neurology, University Hospital Central de Asturias and - - 2014
Onabotulinumtoxin type A (onabotA) has shown efficacy in chronic migraine (CM). Its precise mechanism of action, however, is unknown. To analyse a potential relationship between calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) levels and response to onabotA in CM. Adult patients with CM were recruited. Matched healthy subjects ...
Lisowska Aleksandra A Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, Poznań, - - 2014
Background & Aims: To date, no studies concerning the presence of small intestinal bacterial overgrowth in patients with progressive familial intrahepatic cholestasis were published. Based upon characteristic of progressive familial intrahepatic cholestasis one can expect the coexistence of small intestinal bacterial overgrowth. The aim of the study was to assess ...
Sun Xingshen X Department of Anatomy and Cell Biology, University of Iowa, Iowa City, - - 2014
Cystic fibrosis (CF) is a multiorgan disease caused by loss of a functional cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in many epithelia of the body. Here we report the pathology observed in the gastrointestinal organs of juvenile to adult CFTR-knockout ferrets. CF gastrointestinal manifestations included gastric ulceration, intestinal ...
Pascarenco Ofelia Daniela OD Department of Gastroenterology, Mures County Hospital, University of Medicine and Pharmacy, Targu Mures, Romania. - - 2014
Over the past few decades, the incidence of adenocarcinomas of the gastroesophageal junction has rapidly increased. Barrett's esophagus is a risk factor for esophageal adenocarcinoma, but the role of intestinal metaplasia of the gastric cardia as a precursor in cardia-related cancer is controversial. The aims of the present study were ...
Deesomsak M M Division of Gastroenterology, Department of Internal Medicine, Siriraj Hospital, Mahidol University, Bangkok, - - 2014
We report a patient presenting with chronic diarrhoea of unidentified etiology. Laboratory results showed microcytic anemia, peripheral eosinophilia with negative results of stool sample smears and stool concentration technique. Ancylostoma duodenale was found in the caecum and terminal ileum during colonoscopy. The patient was treated with a 3-day course of ...
Mayer Emeran A EA Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: - - 2014
Alterations in the bidirectional interactions between the intestine and the nervous system have important roles in the pathogenesis of irritable bowel syndrome (IBS). A body of largely preclinical evidence suggests that the gut microbiota can modulate these interactions. A small and poorly defined role for dysbiosis in development of IBS ...
Lähdeaho Marja-Leena ML School of Medicine, University of Tampere and Tampere University Hospital, Tampere, - - 2014
Gluten ingestion leads to small intestinal mucosal injury in patients with celiac disease, necessitating strict lifelong exclusion of dietary gluten. Despite adherence to a gluten-free diet, many patients remain symptomatic and still have small intestinal inflammation. Non-dietary therapies are needed. We investigated the ability of ALV003, a mixture of 2 ...
Dupont Andrew W AW The University of Texas Health Science Center, Houston, Tex., - - 2014
Background/Aims: The intestinal pathophysiology in irritable bowel syndrome (IBS) is largely unknown. The lactulose breath test has been used to identify small bowel bacterial overgrowth in these patients. Methods: We studied intestinal transit in patients with IBS using of the SmartPill® (SP) wireless pH/pressure recording capsule and performed lactulose breath ...
Rutten Erica P A - - 2014
COPD is accepted to be a multicomponent disease with various comorbidities. To our knowledge, the contribution of the GI tract to the systemic manifestation of COPD has never been investigated. This metabolically active organ may experience recurring local oxygen deficits during daily life, leading to disturbed intestinal integrity in patients ...
Wang Zhen-Kai ZK Zhen-Kai Wang, Hui Shi, Shao-Dong Wang, Jiong Liu, Miao-Fang Yang, Chan Liu, Heng Lu, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Nanjing 210002, Jiangsu Province, - - 2014
Behcet's disease (BD) is a rare and life-long disorder characterized by inflammation of blood vessels throughout the body. BD was originally described in 1937 as a syndrome involving oral and genital ulceration in addition to ocular inflammation. Intestinal BD refers to colonic ulcerative lesions documented by objective measures in patients ...
Feng Nan N Nan Feng, Emergency Department, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, - - 2014
To investigate the correlations between serum amylase levels, intestinal permeability (IP), and pancreatic injury and to explore the mechanisms responsible for hyperamylasemia in double-balloon enteroscopy (DBE). A prospective study was conducted in 20 patients who underwent DBE from August 1, 2008 to February 28, 2009. Serum amylase was examined 0, ...
Muraki Motoko M Department of Gastroenterology, Osaka City University Graduate School of Medicine , Osaka , - - 2014
Abstract Objective. Enteric bacteria play a significant role in the pathogenesis of non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal damage. However, the association between small intestinal bacterial overgrowth (SIBO) and NSAID-induced small intestinal damage remains unclear. The aim of the study was to examine the association between SIBO and the presence ...
Matsumoto S S Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, Yokohama, - - 2014
The aim of this study was to evaluate the use of intestinal fatty acid binding protein (I-FABP) and traditional biomarkers in the early diagnosis of acute intestinal ischaemia of different causes. I-FABP, white blood cell (WBC) count, C-reactive protein, base deficit, lactate, lactate dehydrogenase, aspartate aminotransferase, creatine kinase and D-dimer ...
Hedin Charlotte R CR Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, , London, - - 2014
Crohn's disease (CD) is associated with intestinal dysbiosis, altered blood T cell populations, elevated faecal calprotectin (FC) and increased intestinal permeability (IP). CD-associated features present in siblings (increased risk of CD) but not in healthy controls, provide insight into early CD pathogenesis. We aimed to (1) Delineate the genetic, immune ...
Martínez Carmen C Departamento de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, - - 2014
Suitable biomarkers are essential for the design of therapeutic strategies in personalized medicine. Vasoactive intestinal peptide (VIP) has demonstrated immunomodulatory properties in autoimmune murine and ex vivo human models. Our aim was to study serum levels of VIP during the follow-up of an early arthritis (EA) cohort and to analyze ...
Saito Makoto M Department of Internal Medicine and Hematology, Aiiku - - 2014
Tyrosine kinase inhibitors (TKIs) are highly effective in the treatment of chronic myelogenous leukemia (CML), but there have been a few adverse event reports describing gastrointestinal bleeding. We clinically analyzed two patients who developed intestinal bleeding during the administration of TKIs for CML. Platelet counts of both patients were normal. ...
Walker John - - 2014
Purpose: Abnormal gastrointestinal permeability (GIP) has been implicated in a number of diseases, including chronic intestinal inflammatory disorders such as Crohn's as well as non-intestinal immunologic diseases such as diabetes and multiple sclerosis. Although evidence in the literature demonstrates mucosal abnormalities of the digestive barrier in asthma, previous studies have ...
Wiener-Carrillo Isidoro I Surgery Department, Angeles Pedregal Hospital, Mexico City, - - 2014
Intussusception in adult patients represents 5% of all intussusceptions and 1-5% of bowel obstructions in adults. In contrast to pediatric patients, 90% of the time, in adults, it's caused by well-established pathologic mechanisms, such as carcinoma, polyps, diverticula, Meckel diverticula, stenosis, or benign neoplasms. Small intestine intussusceptions are more frequent, ...
Güzel Murat M Department of Emergency Medicine, Samsun Training and Research Hospital, Baris Bulvari Kadikoy Mahallesi no:199, İlkadim, Samsun, Turkey, - - 2013
This study examined the feasibility of using the serum intestinal fatty acid binding protein (I-FABP) level for the early diagnosis of acute mesenteric ischemia, and investigated whether it contributes to the clinical decision-making process. Thirty patients diagnosed with acute mesenteric ischemia, 27 patients with other types of acute abdomen who ...
Rong Jian-Ming JM Department of Geratology, No.454 Hospital of PLA, Nanjing, Jiangsu 210002, P.R. - - 2014
Chymase, a chymotrypsin-like protease, is a non-angiotensin-converting enzyme (ACE) angiotensin II (Ang II)-generating enzyme. The aim of the present study was to investigate whether chymase activity was increased in inflammatory polyps of elderly patients with functional bowel disorder (FBD). This study enrolled 45 elderly patients with FBD and 44 healthy ...
Kintu-Luwaga Ronald - - 2013
Intestinal ischemia is a common complication of intestinal obstruction and arises from impaired perfusion. The resultant local and systemic inflammatory response and bacterial translocation come with a significant degree of morbidity and mortality. This study therefore aimed to investigate the predictive value of elevated levels of serum lactate and phosphate ...
Malamut Georgia - - 2013
Little is known about intestinal CD4+ T-cell lymphoma; this rare malignancy is frequently misdiagnosed. We evaluated diagnostic criteria and factors that might affect its development and outcome. In a retrospective analysis, we analyzed medical records and intestinal specimens from 10 patients diagnosed with intestinal CD4+ T-cell lymphoma among 115 consecutive ...
Pijls Kirsten E - - 2013
Intestinal barrier dysfunction, facilitating translocation of bacteria and bacterial products, plays an important role in the pathophysiology of liver cirrhosis and its complications. Increased intestinal permeability has been found in patients with liver cirrhosis, but data on small and large intestine permeability and tight junctions (TJs) in patients with compensated ...
Li Qiurong - - 2013
We aim to characterize the fungal microbiota in the intestinal mucosa and feces in patients with Crohn's disease (CD). Fungi represent a diverse microbial community in the human intestine and might play a role in the pathogenesis of CD; however, little is known about the structure and composition of the ...
Liboredo Juliana Costa - - 2013
Increased intestinal permeability has been reported in multiple studies of cirrhotic patients, although specific factors associated with this finding have not been fully elucidated. Thus, the aim of this study was to investigate whether there was an association between nutrition status measured by different methods and intestinal permeability in cirrhotic ...
Elkrief Laure - - 2013
The most serious complication of acute mesenteric vein thrombosis (MVT) is acute intestinal ischemia requiring intestinal resection or causing death. Risk factors for this complication are unknown. to identify risk factors for severe intestinal ischemia leading to intestinal resection in patients with acute MVT. We retrospectively analysed consecutive patients seen ...
Lacedonia Donato - - 2013
Background: The aim of this study was to define the involvement of some biomarkers in patients with COPD and Pulmonary Hypertension (PH), with particular attention to subgroups with a PH that is "out of proportion". Materials and Methods: Patients with COPD without PH, with PH and marked airways obstruction and ...
Caio Giacomo - - 2013
A 26-year-old patient was diagnosed as having chronic intestinal pseudo-obstruction with manometric and histopathologic features suggestive of an intestinal myopathy. Histology was characterized by smooth muscle degeneration without inflammatory or immune cells. The severe gut dysfunction required full parenteral nutritional support. After a few months, the patient developed symptomatic tachy-brady ...
Walkowiak J - - 2013
Phenylketonuria (PKU) is an inborn error of amino acid metabolism in which high phenylalanine (Phe) concentrations in the central nervous system adversely affect its development and functioning. In PKU high oxidative stress and inefficiency of free radical scavenging may lead to systemic chronic inflammation. We hypothesised that in PKU gut ...
Takimoto Yoshiyuki Y Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, - - 2014
Anorexia nervosa (AN) patients often experience gastrointestinal complications caused by their malnutrition. We hypothesized that intestinal integrity is disturbed in AN. Therefore, the objective of the present study was to investigate serum diamine oxidase (DAO) activity, which is considered to be a clinical indicator of the integrity of the intestinal ...
Sigalet David L - - 2013
BACKGROUND⁄OBJECTIVES: The relationship between the enteroendocrine hormone glucagon-like peptide 2 (GLP-2) and intestinal inflammation is unclear. GLP-2 promotes mucosal growth, decreases permeability and reduces inflammation in the intestine; physiological stimulation of GLP-2 release is triggered by nutrient contact. The authors hypothesized that ileal Crohn disease (CD) affects GLP-2 release. With ...
El-Salhy Magdy - - 2013
Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder. Post-infectious IBS (PI-IBS) is a subset of IBS that accounts for a large proportion of IBS patients. The PI-IBS symptoms meet the Rome criteria for IBS with diarrhoea (IBS-D) or IBS with mixed bowel habits (IBS-M). A low-grade inflammation ...
Khamaysi Iyad - - 2013
Acute upper gastrointestinal bleeding (UGIB) is the most common reason that the 'on-call' gastroenterologist is consulted. Despite the diagnostic and therapeutic capabilities of upper endoscopy, there is still significant associated morbidity and mortality in patients experiencing acute UGIB, thus this is a true GI emergency. Acute UGIB is divided into ...
Al-Taie O - - 2013
Introduction: In earlier studies, involvement of the small intestine was reported in patients with gastrointestinal lymphoma. Prospective data on the involvement of the small intestine in patients suffering from gastric extranodal MZBCL of MALT do not exist so far. In this study, we investigated the frequency of the involvement of ...
Faleiros-Castro Fabiana Santana - - 2013
Constipation affects 74% of individuals with cerebral palsy. This study aimed to evaluate the results of nursing interventions for treating intestinal constipation associated with cerebral palsy. This quantitative, prospective, comparative study included 50 patients with quadriplegic cerebral palsy and constipation. The main conservative measures included daily consumption of laxative foods ...
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