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Davis Cheryl - - 2013
Background: Parenteral nutrition (PN) is a lifesaving therapy for children with intestinal failure and can now be used chronically without the life-threatening complications of the past. Adequate intravenous trace element supplementation is required as part of a complete nutrition prescription. According to the U.S. Food and Drug Administration (FDA), the ...
Jacobs C - - 2013
BACKGROUND: Whether intestinal dysmotility and the use of a proton pump inhibitor (PPI) either independently or together contributes to small intestinal bacterial overgrowth (SIBO), and/or small intestinal fungal overgrowth (SIFO) is not known. AIM: To investigate the role of dysmotility and PPI use in patients with persistent gastrointestinal complaints. METHODS: ...
Duman Ali Erkan - - 2013
To the Editor, Celiac disease (CD) is an immune-mediated permanent small bowel disorder triggered by the ingestion of gluten-containing food. Although this disease primarily affects the gut, many other tissues and organs may be affected in at least 20-30% of patients, as shown in recent studies on the association of ...
Madsen K B - - 2013
BACKGROUND AND AIMS: The ileocolonic brake is impaired in short bowel syndrome (SBS) patients with distal bowel resections. An attenuated meal-stimulated hormone secretion may cause gastric hypersecretion, rapid gastric and intestinal transit and a poor adaptation. Attempting to restore this ileocolonic brake, this study evaluated the acute effects of continuous ...
Mutanen Annika - - 2013
Background and aims: To evaluate long-term effects of pediatric intestinal failure (IF) on liver histology. Methods: Altogether 38 IF patients at median age of 7.2 years (range 0.2-27) underwent liver biopsy, gastroscopy, abdominal ultrasound and laboratory tests. Sixteen patients were on parenteral nutrition (PN) after 74 PN months (2.5-204). Twenty-two ...
Stelios Stelios F - - 2013
Background. Intestinal mucosal barrier dysfunction in liver cirrhosis and its implicated mechanisms is of great clinical importance because it is associated with the development of serious complications from diverse organs through promotion of systemic endotoxemia. Aim. The present study was designed to investigate whether enterocytes' proliferation, apoptosis and intestinal oxidative ...
Burgstad Carly M - - 2013
OBJECTIVE:: Inadequate nutrition is common in critical illness due in part to gastric stasis. However, recent data suggest that altered small intestinal mucosal function may be a contributing factor. The aim of this study was to examine the effects of critical illness on sucrose absorption, permeability, and mucosal morphology. DESIGN:: ...
Rajilić-Stojanović Mirjana - - 2013
BACKGROUND:: Presence of intestinal microbes is a prerequisite for the development of ulcerative colitis (UC), although deviation of the normal intestinal microbiota composition, dysbiosis, is presumably implicated in the etiology of UC. METHODS:: The fecal microbiota of 30 UC samples obtained from 15 patients who were sampled twice and from ...
Guo Mingxiao - - 2013
ABSTRACT Objectives: To observe the adaptive changes of the intestinal mucosa in patients with short bowel syndrome (SBS) who received intestinal rehabilitation therapy and further evaluate the feasibility of the magnifying endoscopy for monitoring intestinal adaptation. Method: Ten patients with SBS received growth hormone (GH) (0.05 mg/kg/day), oral glutamine (30 ...
Turcotte Jean-Francois - - 2013
BACKGROUND: Altered intestinal permeability and mucosal inflammation have been reported in irritable bowel syndrome (IBS) patients. Increased cell extrusion in the epithelium as measured by epithelial gaps may be associated with barrier dysfunction and may lead to mucosal inflammation. Confocal laser endomicroscopy can be used to identify and quantitate epithelial ...
Gedde-Dahl Merete - - 2013
Neuroendocrine tumors (NETs) arising in the small intestine are known to produce vasoactive substances, including serotonin, that may result in the carcinoid syndrome (flushing, diarrhea, bronchoconstriction, and carcinoid heart disease). Measurement of the serotonin breakdown product 5-hydroxyindoleacetic acid (5-HIAA) in urine is important in diagnosing and monitoring of patients with ...
Zammit Adrian - - 2013
Small intestinal intramural haematomas may develop spontaneously, especially in patients with deranged clotting function. We present a case of a 57-year-old man who developed abdominal pain in the setting of abnormal clotting function secondary to an inadvertent warfarin overdose. A CT scan showed thickening of parts of the distal ileum, ...
Dorofeyev A E - - 2013
Background. The mucus layer in the gastrointestinal tract plays important role in host innate defense, regulation of secretion, and absorption processes, maintaining colonization resistance, which composes the integrity of protective mucus barrier in the large intestine. Investigations of mucin expression in the colon mucosa can improve the understanding of protective ...
van Wamelen Daniel J - - 2013
To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus. Postmortem cohort study. Eight patients with HD and eight control subjects matched for sex, age, clock time and month of death, postmortem delay, and ...
Russo Francesco - - 2013
Several GI peptides linked to intestinal barrier function could be involved in the modification of intestinal permeability and the onset of diarrhea during adjuvant chemotherapy. The aim of the study was to evaluate the circulating levels of zonulin, glucagon-like peptide-2 (GLP-2), epidermal growth factor (EGF) and ghrelin and their relationship ...
Jugel Constanze - - 2013
Severe polyneuropathy has been observed in a number of patients treated for Parkinson's disease with Levodopa/Carbidopa intestinal gel infusion. This may reflect a rare individual complication or a systematic side effect. To investigate whether peripheral nerve function differed between patients with oral treatment versus Levodopa/Carbidopa intestinal gel infusion. In an ...
Kinoshita Hiroto - - 2013
Objective To investigate the short- and long-term efficacy and safety of infliximab (IFX) in intestinal Behçet's disease (BD) patients in a retrospective cohort study. Methods Among 43 consecutive patients with intestinal BD presenting at the same clinic, 15 with active disease and receiving standard treatment were given IFX infusions (5 ...
Young Vincent B VB Department of Internal Medicine, Division of Infectious Diseases, Ann Arbor, MI, USA. - - 2013
The indigenous gut microbiota are thought to play a crucial role in the development and maintenance of the abnormal inflammatory responses that are the hallmark of inflammatory bowel disease. Direct tests of the role of the gut microbiome in these disorders are typically limited by the fact that sampling of ...
Reiberger T - - 2012
OBJECTIVE: Evaluation of gastrointestinal permeability and bacterial translocation in cirrhotic patients with portal hypertension (PHT) prior and after nonselective betablocker (NSBB) treatment. DESIGN: Hepatic venous pressure gradient (HVPG) was measured prior and under NSBB treatment. Gastroduodenal and intestinal permeability were assessed by the sucrose-lactulose-mannitol (SLM) test. Anti-gliadin and anti-endomysial antibodies ...
Korst Robert J - - 2012
OBJECTIVE: Radiofrequency ablation can eradicate Barrett's esophagus successfully in the majority of cases. We sought to determine (1) how often intestinal metaplasia is detected during follow-up endoscopy after successful ablation and (2) patterns of persistent/recurrent intestinal metaplasia. METHODS: Patients ablated successfully during a phase II clinical trial of radiofrequency ablation ...
Layec Sabrina - - 2012
BACKGROUND: Segmental reversal of the small bowel (SRSB) is proposed in patients with short-bowel syndrome (SBS) as a rehabilitative therapy, but its effects on absorption have not been studied. OBJECTIVE: We aimed to determine intestinal macronutrient absorption and home parenteral nutrition (HPN) dependence in SBS patients with intestinal failure. DESIGN: ...
Duytschaever Gwen - - 2012
BACKGROUND: Recurrent antimicrobial interventions and disease-related intestinal dysfunction are suspected to contribute to the dysbiosis of the gastrointestinal microbial ecosystem in patients with cystic fibrosis (CF). The present study set out to detect and identify microbial discriminants in the gut microbiota composition that are associated with CF-related intestinal dysbiosis. METHODS: ...
Harmanci Ozgur - - 2012
Red cell distribution width (RDW) has been shown as a distinctive marker of mortality and morbidity in a wide spectrum of conditions related to systemic inflammation or deficiency of antioxidant nutrients. We aimed to investigate the predictive value of RDW in detection of intestinal atrophy in celiac disease (CD). Iron ...
Tseng Wei-Cheng - - 2012
Tuberculous peritonitis is a devastating complication of peritoneal dialysis (PD). Presentations of tuberculous peritonitis range from the common wet ascitic form to the rare fibroadhesive form, which is clinically indistinguishable from encapsulating peritoneal sclerosis. We describe a 76-year-old man on continuous ambulatory PD for three months developing wet ascitic form ...
Camaschella Clara - - 2012
Microcytic hypochromic anaemias are a result of defective iron handling by erythroblasts that decrease the haemoglobin content per red cell. Recent advances in our knowledge of iron metabolism and its homeostasis have led to the discovery of novel inherited anaemias that need to be distinguished from common iron deficiency or ...
Jäkel J - - 2012
Only few case studies address pseudo-obstruction, a disorder - which often frustrates clinicians and patients due to an unclear diagnosis and limited therapeutic options. Thus, the aim of this paper is to investigate a relevant case concerning a patient presenting with symptoms of acquired chronic intestinal pseudo-obstruction (CIPO). After one ...
Dutta Amit Kumar - - 2012
BACKGROUND AND AIMS: Narrow band imaging (NBI) detects mucosal surface details (pit pattern) as well as the microvasculature pattern of mucosa. In premalignant conditions the pattern and regularity of pits and microvasculature are altered. We aimed to assess whether NBI is superior to conventional white light gastroscopy (WLG) in detecting ...
Fukushima Takeshi - - 2012
Postprandial hypotension (PPH) is a major clinical problem in patients with autonomic failure such as that observed in multiple system atrophy (MSA). The pathophysiology of PPH remains unclear, although autonomic dysfunction and gastrointestinal vasoactive peptides have been suspected to participate in its pathogenesis. We measured blood pressure and plasma levels ...
Florian Anca - - 2012
The aim of this study was to analyze the geometric pattern of hypertrophy (HT) in patients with asymmetrical septal hypertrophic cardiomyopathy (HCM) using cardiac magnetic resonance (CMR) and to test the hypothesis that at least in some patients, the HT follows a longitudinal spiral pattern. The highly heterogeneous phenotypic expression ...
Kim Soo Hyun - - 2012
To investigate corticospinal tract (CST) status using diffusion tensor imaging (DTI) in patients who had clinical symptom of torticollis but no definite cause of sustained symptom of torticollis. We evaluated 10 patients with sustained torticollis and 12 age-matched control subjects. All patients showed no specific fibromatosis coli findings on neck ...
Maconi G - - 2012
Intestinal gas is a frequent cause of poor visualization during gastrointestinal ultrasound (US). The enzyme alpha-galactosidase may reduce intestinal gas production, thereby improving abdominal US visualization. We compared the efficacies of alpha-galactosidase and active charcoal in improving US visualization in patients with previous unsatisfactory abdominal US scans caused by excessive ...
Wu Tao - - 2012
The patho-mechanism of scoliosis in patients with syringomyelia (SM) secondary to Chiari malformation type I (CMI) remains unknown up till now. In small sample studies published recently, there was an observation that curve direction tended to be on the same side as the dominant side of tonsillar displacement or the ...
Chen Chi-Yi - - 2012
We report a case of intestinal obstruction and duodenal dissection resulting from an intramural haematoma after therapeutic upper digestive endoscopy with injection therapy for a bleeding duodenal ulcer in a patient on long-term haemodialysis with liver cirrhosis.
Machowska-Majchrzak Agnieszka - - 2012
Background and purpose: The aim of the study was to perform an analysis of the recorded tremor using accelerometry and select those parameters that are the most useful in differentiation of tremor types. Material and methods: We examined 45 patients with parkinsonian tremor (PT), 39 patients with essential tremor (ET) ...
Karlsen Stine - - 2012
Gastrointestinal dysmotility may be involved in the development of bacterial translocation and infection in patients with liver cirrhosis. The aim of the present study was to describe gastric, small intestinal and colorectal motility and transit in patients with liver cirrhosis and portal hypertension using a magnet-based Motility Tracking System (MTS-1) ...
Lee Jung M - - 2012
There is evidence of intestinal inflammation in patients with CF. Intestinal inflammation may negatively impact the nutritional status of patient with CF, which adversely affects pulmonary function and survival. This paper provides an up-to-date review of intestinal inflammation in CF and an evaluation of utility of two specific faecal inflammatory ...
Kang Jeong-Eun - - 2012
Here we report the cytogenetic and clinical manifestations observed in a patient with a rec(20)dup(20p)inv(20)(p11.2q13.3)mat. The patient was a full-term newborn girl with asymmetric intrauterine growth restriction and multiple congenital malformations, including a ventricular septal defect, pulmonary atresia, ambiguous genitalia, clinodactyly, and sacral dimpling. To our knowledge, this is the ...
Pao Winnie C WC Department of Neurology, Mayo Clinic, Jacksonville, FL, - - 2011
Hippocampal sclerosis (HpScl) in the elderly is often associated with neurodegeneration. We studied the clinical and pathologic features of HpScl in 205 consecutive patients with dementia who came to autopsy from 1997 to 2008, focusing on associations with TAR DNA-binding protein 43 (TDP-43) pathology and allelic variants in the progranulin ...
Treeprasertsuk Sombat - - 2011
We aimed to describe the effects of parenteral bisphosphonates on bone mineral density (BMD) changes in primary biliary cirrhosis (PBC) patients with osteoporosis. Seventeen PBC patients with osteoporosis diagnosed between 1996 and 2005 were enrolled retrospectively. All patients received one of the following parenteral bisphosphonates: zoledronic acid, pamidronate disodium, or ...
Reitzen Shari D - - 2011
To objectively determine the prevalence of occult nasal base asymmetry in adults with wide nasal tips using a standard photographic editing program. We performed a retrospective observational study in a private practice, ambulatory care setting. The photographs of 100 randomly selected patients undergoing rhinoplasty who presented with excessive nasal tip ...
Ang Marcus - - 2011
Aim To identify clinical risk factors for obtaining an 'equivocal' T-SPOT.TB result in patients consistent with tuberculosis (TB)-associated uveitis (TAU). Methods Prospective cohort study of consecutive new patients, with ocular signs consistent with TAU at a single tertiary centre enrolled over 15 months. All subjects underwent ocular and systemic evaluation, ...
Viau Krista S - - 2011
Patients with treated phenylketonuria (PKU) can have subtle deficits in intellect, academic skills, and executive functioning. This study evaluates the relationship between intellectual outcome and concentration/variation in blood phenylalanine (Phe) during specific developmental periods (0-6 years, 7-12 years, >12 years) in our patients with PKU. Verbal comprehension, perceptual reasoning, and ...
Du Yi - - 2011
To describe the clinical profile of unilateral optic neuritis (ON) in a Chinese population, we reviewed retrospectively the records of 100 patients (66% female; age 18-74 years) diagnosed with unilateral ON between 2003 and 2009 at three hospitals in Guangxi Province, China. Ocular pain was noted in 40% and disc ...
Irazabal Maria V - - 2011
Autosomal dominant polycystic kidney disease (ADPKD) patients have an increased risk for intracranial aneurysms (IAs). The importance of screening for unruptured IAs (UIAs) depends on their risks for growth and rupture. ADPKD patients with UIAs found by presymptomatic screening with magnetic resonance angiography (MRA) during 1989 to 2009 were followed ...
Rosa Djf - - 2011
Introduction  Psoriasis is a disease with proinflammatory state that has been associated with an increased risk of cardiovascular disease. Method  This is a cross-sectional, observational study, with analysis of 98 patients being treated for psoriasis. Several variables were analysed: gender, age, weight, height, Psoriasis Area and Severity Index (PASI), blood ...
Muñoz-Rojas María Verónica - - 2011
Mucopolysaccharidosis I (MPS I) comprises a spectrum of clinical manifestations and is divided into three phenotypes reflecting clinical severity: Hurler, Hurler-Scheie, and Scheie syndromes. There may be important variations in clinical manifestations of this genetic disease in patients residing in different regions of the world. Using data from the MPS ...
Fröhlich-Reiterer Elke E - - 2011
: Parietal cell antibodies (PCA) are markers of autoimmune gastritis (AG). AG can lead to hypergastrinemia and iron-deficiency anaemia (IDA). Compared to healthy controls, adults with type 1 diabetes mellitus (T1DM) show a higher prevalence of PCA (1% vs 20%). The aim of the present study was to evaluate the ...
Jung H H - - 2011
Background/Aims: Previous studies have suggested that serum fetuin-A, a calcification inhibitor, predicts mortality in dialysis patients. This study investigated the relationships between fetuin-A, vascular calcification, and outcome in such patients. Methods: 58 patients on maintenance hemodialysis underwent multirow spiral computed tomography to determine baseline coronary artery calcification (CAC) score. Serum ...
Rijlaarsdam-Hermsen D - - 2011
The aim of this study was to determine the prognostic value of a coronary artery calcium score (CACS) of 0 in patients with stable chest symptoms and to compare it as a first-line test with bicycle exercise testing (X-ECG). Altogether, 315 consecutive patients over 44 years of age, with stable chest ...
Lee C-T - - 2011
Aims: Vascular calcification is a common complication among dialysis patients and its pathogenesis involves a variety of factors. The roles of pro-inflammatory cytokines and residual kidney function (RKF) in peritoneal dialysis (PD) patients with vascular calcification have not been investigated. Materials and methods: 157 stable PD patients were enrolled. All ...
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