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Eder Piotr - - 2013
INTRODUCTION Magnetic resonance enterography (MRE) is believed to be a reliable diagnostic method in assessing small bowel Crohn's disease (CD) activity, however none of the previously proposed quantifying MRE scores has been in use in everyday clinical practice. OBJECTIVES To construct a Simple Enterographic Activity Score for CD (SEAS-CD) and to investigate ...
Larghi Alberto - - 2012
Preoperative determination of Ki-67 expression, an important prognostic factor for grading nonfunctioning pancreatic endocrine tumors (NF-PETs), remains an important clinical challenge. To prospectively evaluate the feasibility, yield, and clinical impact of EUS-guided fine-needle tissue acquisition (EUS-FNTA) with a large-gauge needle to obtain tissue samples for histologic diagnosis and Ki-67 analysis ...
Chakravarti Anita - - 2012
Dengue infection is endemic in India with frequent epidemics of Dengue Fever/Dengue Hemorrhagic Fever. The outbreaks vary in the commonest serotype in circulation during that period, predominant laboratory findings and clinical manifestations. This study was carried during the outbreak of dengue in Delhi in 2009. Clinical assessment and laboratory investigations ...
Martins-Oliveira Alisson - - 2012
We investigated whether three relevant polymorphisms (C-1562T, microsatellite -90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura ...
Demontis Maria Antonietta - - 2012
Background: HTLV-1 proviral load (PVL) in peripheral blood mononuclear cells (PBMC) is high in patients with Adult T-cell Leukaemia/Lymphoma and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis and in some asymptomatic carriers, but fluctuates. Objectives: To document ranges of HTLV PVL across a broader spectrum of diseases and tissues; to quantify the normal ...
Ching Victor - - 2012
OBJECTIVES: The objective of this study was to assess the frequency of geographic tongue and fissured tongue (GFT) in patients with burning mouth syndrome (BMS). Our hypothesis was that benign soft tissue changes to the tongue, such as GFT, are associated with BMS. STUDY DESIGN: Retrospective review of 161 patients ...
Lindholm Henry - - 2012
PURPOSE: At (18)F-2-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) examinations a high tracer uptake of the skeletal muscles is sometimes encountered which can lead to reduced uptake in pathological lesions. This was evaluated in retrospect in patients being recalled for a repeat examination after reducing the muscular uptake. METHODS: Ten ...
Takashio Seiji - - 2012
Cardiac involvement in systemic amyloidosis causes detrimental prognosis; therefore, early detection and classification are important to develop appropriate therapeutic strategies. Subcutaneous tissue biopsy is a useful screening procedure for systemic amyloidosis; however, its diagnostic and prognostic value in patients with cardiac amyloidosis remains elusive. Thus, we investigated the value of ...
Bugatti Serena - - 2012
Although rheumatoid arthritis (RA) is traditionally considered as the prototype of destructive arthritis, the course of the disease varies considerably, with some patients experiencing more rapid progression of joint damage and disability than others. Given the increasing availability of treatment targets and options, timely recognition of individual's outcomes could allow ...
Cotton Bryan A - - 2012
Hyperfibrinolysis (HF) has been reported to occur in a range of 2% to 34% of trauma patients. Using rapid thromboelastography (r-TEG), we hypothesized that HF is (1) rarely present at admission on patients with severe injury and (2) associated with crystalloid hemodilution. To further strengthen this hypothesis, we created an ...
Atar Murat - - 2012
Abstract Objective.The aim of this study was to determine the frequency of anatomical variations of the colon associated with the kidney. Material and methods. A retrospective analysis was performed on 1000 consecutive abdominal computed tomography (CT) scans performed between July 2010 and September 2011. A line parallel to the horizontal ...
Nitsche Alejandro - - 2012
Raynaud, digital ulcers and calcinosis are frequent manifestations of patients with systemic sclerosis. Digital ulcers are seen in more than half of the patients with scleroderma. Hospitalizations, ischemic complications and impairment of hand function are frequently observed in patients with digital ulcers, especially if treatment is delayed. Rapid and intensive ...
Yokoyama Shota - - 2012
We report the use of intravenous tissue plasminogen activator (t-PA) therapy in a 38-year-old patient who was later diagnosed with unilateral moyamoya syndrome. The patient had a sudden onset of unconsciousness, vomiting, dysarthria, and tetraparesis. A neurologic examination revealed consciousness disturbance, right central facial nerve palsy, dysarthria, and tetraparesis with ...
Inoue Manabu M Stanford Stroke Center, Stanford University Medical Center, Stanford, CA, USA. - - 2012
The malignant profile has been associated with poor outcomes after reperfusion in the 3- to 6-hour time window. The aim of this study was to estimate the incidence and prognostic implications of the malignant profile, as identified by CT perfusion, in intravenous tissue-type plasminogen activator-treated patients who were imaged <3 ...
Gilchrist Kevin B - - 2012
Invasive candidiasis occurs in the gastrointestinal tract, especially in neutropenic patients. We were interested in determining whether invasive fungi formed amyloid in humans as they are known to do in vitro. We also sought to characterize the consequence(s) of such amyloid formation. Tissue from 25 autopsy patients with invasive candidiasis ...
Ochi Hironori H Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine, Ehime, - - 2012
The aim of this study was to prospectively measure liver stiffness with real-time tissue elastography in patients with nonalcoholic fatty liver diseases (NAFLD) and to compare the result with the clinical assessment of fibrosis using histological stage. One hundred and eighty-one prospectively enrolled patients underwent real-time tissue elastography, with the ...
Faglia Ezio - - 2012
From January 2007 to December 2009, 207 diabetic patients were consecutively admitted to our foot center because of osteomyelitis of a phalanx or metatarsal head. The removal of infected bone was performed by internal bone resection in 110 patients (group A) and amputation in 97 patients (46.9%; group B). Dehiscence ...
Nagashima Koichi - - 2012
BACKGROUND: -Although increased epicardial adipose tissue (EAT) volume is known to be associated with increased prevalence of atrial fibrillation (AF), the exact mechanisms are unclear. Therefore, we investigated whether EAT locations were associated with high dominant frequency (DF) sites and/or complicated fractionated atrial electrogram (CFAE) sites during AF. METHODS AND ...
Vermess David - - 2012
The thickness of the prevertebral soft tissue (PVST) is instrumental in helping detect cervical spine injuries in the pediatric population. Current parameters for normal PVST thickness in that population are based on lateral radiographs because there have been no studies to date defining age-dependent normal measurements on MDCT. With the ...
Melchiorre Daniela - - 2012
OBJECTIVE: Hemarthrosis triggers hemophilic arthropathy, involving the target joints. The histopathogenesis of blood-induced joint damage remains unclear. The triad of receptor activator of nuclear factor- κB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG; RANK-RANKL-OPG) controls bone turnover. Our aim was to evaluate RANK-RANKL-OPG expression in the synovium of hemophilic patients ...
Choudhary Narendra S - - 2012
There is sparse literature on the association of adipose tissue with liver histology in patients with nonalcoholic fatty liver disease (NAFLD). To study the correlation of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) with liver histology in Indian patients with NAFLD. A single slice ...
Czekajska-Chehab Elżbieta - - 2012
Lipomatous hypertrophy of the interatrial septum (LHIS) is a benign disorder characterized by fat accumulation in the interatrial septum (IAS). The purpose of the study was to analyze the incidental detection of LHIS in patients with various clinical conditions, referred to ECG-gated multislice computed tomography (ECG-MSCT) examinations of the heart. ...
Turkmen Kultigin K Department of Nephrology, Selcuk University Meram School of Medicine, Konya, Turkey. - - 2013
Thoracic peri-aortic fat tissue (PFT) and epicardial adipose tissue (EAT) are metabolically active visceral fat deposits surrounding the thoracic aorta and the heart, respectively. Various studies have demonstrated a positive predictive value of both PFT and EAT for coronary artery disease in the general population. In the present study, we ...
Dietz Jenna J Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, - - 2013
Subthalamic (STN) and globus pallidus (GP) deep brain stimulation (DBS) have been previously shown to be efficacious in the treatment of selected Parkinson patients with medication resistant motor fluctuations and/or tremor. Deep brain stimulation of the STN has been implicated with more cognitive and mood side effects as compared to ...
De Bona Karine S - - 2012
OBJECTIVES: Metabolic Syndrome (MetS) is considered a state of chronic inflammation. This study aimed to ascertain selected parameters of purinergic and cholinergic systems related to glucose metabolism and inflammation, as well as (γ)-glutamyltransferase (GGT) and N-acetyl-b-glucosaminidase (NAG) activities and lipoperoxidation in lymphocytes of patients with MetS. Design and Methods The ...
Farrell Christopher C Division of Gastroenterology, Lankenau Hospital, Wynnewood, PA 19096, United - - 2012
To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation ...
Sangha Navdeep - - 2012
Dabigatran etexelate is a new oral direct thrombin inhibitor that has been approved by the US Food and Drug Administration to prevent stroke in patients with nonvalvular atrial fibrillation. A 51-year-old man with a history of atrial fibrillation who was taking dabigatran presented with an acute ischemic stroke. The patient ...
Hoon Song Young - - 2012
ABSTRACT: Clinical deterioration among hemodynamically stable sepsis patients occurs frequently, and patients with intermediate lactate levels (between 2.0 and 4.0 mmol/L) are particularly at risk for mortality. The aim of this study was to identify factors for predicting early deterioration in sepsis patients with intermediate levels of serum lactate. A ...
Park Jae Hyung - - 2012
BACKGROUND: The existence of myofibroblasts (MFBs) and the role of subendocardial smooth muscle (SSM) layer of human atrial tissue in atrial fibrillation (AF) have not yet been elucidated. We hypothesized that the SSM layer and MFB play some roles in atrial structural remodeling and maintenance of valvular AF in patients ...
Gorczyca M E - - 2012
Background: Tissue factor pathway inhibitor (TFPI) is the major inhibitor of tissue factor initiated coagulation, making it an interesting and novel therapeutic target in hemophilia treatment. The aptamer BAX499 (formerly ARC19499) is designed to improve hemostasis by specifically inhibiting TFPI. Objectives: The aim of the study was to examine the concentration-dependent augmentation ...
Szczesny Wojciech - - 2012
BACKGROUND: Obesity is a well-established risk factor for incisional hernia development. The exact causative factors have not been clearly defined, and development may result from structural disruptions in the connective tissue of the fasciae. The goal of this study was to compare the content of elastin in the rectus muscle ...
Grond-Ginsbach Caspar C Department of Neurology, University of Heidelberg, Heidelberg, Germany. - - 2012
Cervical artery dissection (CeAD) occurs in healthy young individuals and often entails ischemic stroke. Skin biopsies from most CeAD-patients show minor connective tissue alterations. We search for rare genetic deletions and duplication that may predispose to CeAD. Forty-nine non-traumatic CeAD-patients with electron microscopic (EM) alterations of their dermal connective tissue ...
Lindhardt Johansen Marie - - 2012
Context:Most previous studies of 45,X/46,XY mosaicism are case reports or have described single aspects of the disease.Objective:The objective was to provide longitudinal data of patients with 45,X/46,XY mosaicism.Design:This was a retrospective, longitudinal study conducted from June 1990 to January 2012.Setting:The study took place at a tertiary pediatric and andrological referral ...
Espinosa-Hernández Mario - - 2012
Introduction: membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. The diagnosis is based on typical findings observed using electron microscope (EM) and immunofluorescence (IF) studies. On some occasions, tissues are only available for analysis using an optical microscope (OM); in these cases, it can be ...
Seet Raymond C S - - 2012
BACKGROUND: Whether obese and overweight stroke patients respond differently to intravenous thrombolysis is unclear. The purpose of this study is to determine the influence of obesity and risk components of metabolic syndrome to stroke recovery in patients undergoing intravenous thrombolysis. METHODS: Outcomes after recombinant tissue plasminogen activator treatment were compared ...
Kiratli Hayyam - - 2012
To report 3 patients with conjunctival cavernous hemangioma in association with multiple recurrent episodes of subconjunctival hemorrhage. Retrospective clinical case series. We studied 3 patients, 11, 13, and 21 years of age, respectively, each of whom had a small, solitary, and irregular multiloculated vascular mass on the temporal bulbar conjunctiva ...
Sodani Ajoy - - 2012
Extramedullary hematopoiesis is a compensatory response in patients with thalassemia and other chronic anemia and can result in compressive myelopathy, if untreated. Two young adults with history of thalassemia presented with symptoms of spinal cord compression. Presence of extramedullary hematopoiesis was confirmed by magnetic resonance imaging. Both the patients were ...
Burghaus Lothar - - 2012
Space-occupying brain edema may lead to a malignant course in patients with large middle cerebral artery infarction. Decompressive hemicraniectomy has to be initiated early to prevent further tissue damage. In this retrospective study, we analyzed electroencephalography (EEG) and evoked potentials (EPs), obtained within 24 h after onset of stroke, in 22 ...
Narayan Sanjiv M - - 2012
The perpetuating mechanisms for human atrial fibrillation (AF) remain undefined. Localized rotors and focal beat sources may sustain AF in elegant animal models, but there has been no direct evidence for localized sources in human AF using traditional methods. We developed a clinical computational mapping approach, guided by human atrial ...
Magin William S - - 2012
BACKGROUND: Recent studies show that diseased intestinal tissues of patients with Crohn's disease (CD) contain obstructed lymphatics, granulomas, and tertiary lymphoid organs, representing responses to persistent antigen. METHODS: Forty-seven tissue sections from 28 CD patients and 20 tissue sections from 17 control patients were studied. Tissues were immunostained with antibody ...
Ishak G E - - 2012
BACKGROUND AND PURPOSE:Often diagnosed at birth or in early childhood, mitochondrial disease presents with a variety of clinical symptoms, particularly in organs and tissues that require high energetic demand such as brain, heart, liver, and skeletal muscles. In a group of pediatric patients identified as having complex I or I/III ...
Takeuchi Satoru - - 2012
OBJECTIVE: Intravenous tissue plasminogen activator (IV tPA) is an approved treatment for acute ischemic stroke. However, the effects of decompressive craniectomy (DC) after IV tPA administration for ischemic stroke are still largely unknown. The aim of this study was to investigate the safety and outcomes of DC after IV tPA ...
Schulze Maximilian - - 2012
RATIONALE AND OBJECTIVES: The aim of this study was to assess perfusion parameters in atypical pneumonia of heavily immunocompromised hematologic patients suspected of having invasive mycosis using volume perfusion computed tomography and establish their diagnostic role. MATERIALS AND METHODS: Volume perfusion computed tomographic data from 21 consecutive immunocompromised patients presenting ...
Salem Omar Alaa Mabrouk - - 2012
Background: Tissue Doppler imaging-obtained isovolumetric myocardial acceleration (IVA) is load independent, reportedly predicts systolic functions, and correlates with exercise capacity in patients with reduced ejection fraction (EF). We hypothesized that IVA correlates with the pulmonary capillary wedge pressure (PCWP) in patients with reduced EF. Methods and Results: Of 113 patients, ...
Zhang Qingxian - - 2012
Background: Tacrolimus has been reported to be effective in refractory nephrotic syndrome, such as focal segmental glomerulosclerosis and membranous nephropathy. Some IgA nephropathy (IgAN) patients with massive proteinuria showed resistance to steroids and/or cytotoxic immunosuppressants based on the supportive therapy with renin- angiotensin system blockade. The efficacy and safety of ...
Nowicka-Sauer K - - 2012
Objective: The aims of the study were to assess cognitive functions (CF) in patients with mixed connective tissue disease (MCTD) and to compare MCTD patients with systemic lupus erythematosus patients with and without neuropsychiatric manifestations (NP-SLE and non-NP-SLE, respectively) in terms of CF. Methods: Neuropsychological examination was performed in 141 ...
Pierdomenico Sante D - - 2012
Hypertension and other risk factors (RFs) predispose to carotid plaques (CPs). An association between left ventricular hypertrophy (LVH) or epicardial adipose tissue (EAT) and CPs has also been reported. The aim of the study was to evaluate whether the assessment of LVH and EAT thickness, beyond RFs, would be of ...
Snidvongs Kornkiat - - 2012
BACKGROUND: Tissue eosinophilia in chronic rhinosinusitis (CRS) is a marker of inflammatory disorders recalcitrant to surgical intervention. Eosinophilic chronic rhinosinusitis (ECRS) is traditionally associated with asthma, polyps, aspirin sensitivity, high serum eosinophilia, and elevated immunoglobulin E (IgE). However, patients with ECRS may not present with these associations and there is ...
Mara Michal - - 2012
Aim:  Several atypical hysteroscopy findings have been described in association with uterine artery embolization (UAE). The purpose of this study was to evaluate the types and frequency of these findings in the largest published series of patients. Material and Methods:  Premenopausal patients after bilateral UAE for symptomatic intramural fibroid underwent ...
Reed Robyn C - - 2012
Abstract Background: Symmetrical peripheral gangrene (multi-limb ischemia without large artery occlusion) is a rare condition usually associated with disseminated intravascular coagulation (DIC), hemodynamic compromise and/or sepsis. However, it has not been described in patients on extracorporal membrane oxygenation (ECMO). Methods: Four pediatric patients developed symmetrical peripheral gangrene on ECMO following ...
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